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Gerd Krause

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

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Cercopithecus aethiops

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Inna Hoyer; Annika Kreuchwig; Ralf Schülein; Ann-Karin Haas; Gerd Krause
Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.
Anke Teichmann; Burkhard Wiesner; Gerd Krause; Annika Kreuchwig; Claudia Rutz; Ralf Schülein
The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.
Anna Veshnyakova; Michael Fromm; Susanne M Krug; Sebastian L Mueller; Jörg Piontek; Jonas Protze; Gerd Krause
Determinants contributing to claudin ion channel formation.

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All Publications

2013: Inna Hoyer; Annika Kreuchwig; Ralf Schülein; Ann-Karin Haas; Gerd Krause
Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.
Biochemical Society transactions 2013;41(1):213-7.
2012: Anke Teichmann; Burkhard Wiesner; Gerd Krause; Annika Kreuchwig; Claudia Rutz; Ralf Schülein
The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.
The Journal of biological chemistry 2012;287(32):27265-74.
2012: Anna Veshnyakova; Michael Fromm; Susanne M Krug; Sebastian L Mueller; Jörg Piontek; Jonas Protze; Gerd Krause
Determinants contributing to claudin ion channel formation.
Annals of the New York Academy of Sciences 2012;1257():45-53.
2012: Ralf Schülein; Carolin Westendorf; Gerd Krause; Walter Rosenthal
Functional significance of cleavable signal peptides of G protein-coupled receptors.
European journal of cell biology 2012;91(4):294-9.
2012: Anna Veshnyakova; Negar Waziri; Ivonne Heise; Jörg Piontek; Jonas Protze; Gerd Krause
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins.
The Journal of biological chemistry 2012;287(3):1698-708.
2012: Gerd Krause; Annika Kreuchwig; Gunnar Kleinau
Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.
PloS one 2012;7(12):e52920.
2011: Jörn Saupe; Christian Schillinger; Silke Radetzki; Yvette Roske; Anne Diehl; Udo Heinemann; Nestor Kamdem; Gerd Krause; Hartmut Oschkinat; Jörg Rademann
Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain.
ChemMedChem 2011;6(8):1411-22.
2011: Gunnar Kleinau; Gerd Krause; Annika Kreuchwig; Claudia Rutz; Jens Furkert; Ann-Karin Haas; Inna Hoyer; Catherine L Worth; Ralf Schülein
From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).
The Journal of biological chemistry 2011;286(29):25859-71.
2011: Gunnar Kleinau; Anne Diehl; Paul Grzesik; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Defining structural and functional dimensions of the extracellular thyrotropin receptor region.
The Journal of biological chemistry 2011;286(25):22622-31.
2011: Annika Kreuchwig; Gunnar Kleinau; Franziska Kreuchwig; Catherine L Worth; Gerd Krause
Research resource: Update and extension of a glycoprotein hormone receptors web application.
Molecular endocrinology (Baltimore, Md.) 2011;25(4):707-12.
2011: Anita Kinne; Ralf Schülein; Gerd Krause
Primary and secondary thyroid hormone transporters.
Thyroid research 2011;4 Suppl 1():S7.
2011: Catherine L Worth; Annika Kreuchwig; Gunnar Kleinau; Gerd Krause
GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models.
BMC bioinformatics 2011;12():185.
2011: Jörg D Wichard; Antonius Marinus ter Laak; Gerd Krause; Nikolaus Heinrich; Ronald Kühne; Gunnar Kleinau
Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling.
PloS one 2011;6(2):e16811.
2011: Ann-Karin Haas; Gunnar Kleinau; Inna Hoyer; Susanne Neumann; Jens Furkert; Claudia Rutz; Ralf Schülein; Marvin C Gershengorn; Gerd Krause
Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.
Cellular and molecular life sciences : CMLS 2011;68(1):159-67.
2010: Jens Lättig; Gerd Krause
[Causes of selectivity, activation and inhibition. Molecular mechanisms of endothelin-receptor recognition].
Pharmazie in unserer Zeit 2010;39(6):442-7.
2010: Franziska Winkler; Gunnar Kleinau; Patrick Tarnow; Anne Rediger; Lisa Grohmann; Imke Gaetjens; Gerd Krause; Dagmar l'Allemand; Annette Grüters; Heiko Krude; Heike Biebermann
A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6.
The Journal of clinical endocrinology and metabolism 2010;95(8):3605-10.
2010: Gunnar Kleinau; Ann-Karin Haas; Susanne Neumann; Catherine L Worth; Inna Hoyer; Jens Furkert; Claudia Rutz; Marvin C Gershengorn; Ralf Schülein; Gerd Krause
Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2347-54.
2010: Anna Veshnyakova; Ingolf E Blasig; Gerd Krause; Jonas Protze; Jan Rossa; Jörg Piontek
On the interaction of Clostridium perfringens enterotoxin with claudins.
Toxins 2010;2(6):1336-56.
2010: Gunnar Kleinau; Annika Kreuchwig; Catherine L Worth; Gerd Krause
An interactive web-tool for molecular analyses links naturally occurring mutation data with three-dimensional structures of the rhodopsin-like glycoprotein hormone receptors.
Human mutation 2010;31(6):E1519-25.
2010: Gunnar Kleinau; Holger Jaeschke; Catherine L Worth; Sandra Mueller; Jorge Gonzalez; Ralf Paschke; Gerd Krause
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.
PloS one 2010;5(3):e9745.
2009: Kristin Pankow; Anja Schwiebs; Matthias Becker; Wolf-Eberhard Siems; Gerd Krause; Thomas Walther
Structural substrate conditions required for neutral endopeptidase-mediated natriuretic Peptide degradation.
Journal of molecular biology 2009;393(2):496-503.
2009: Susanne Neumann; Wenwei Huang; Steve Titus; Gerd Krause; Gunnar Kleinau; Anna Teresa Alberobello; Wei Zheng; Noel Southall; James Inglese; Christopher P Austin; Francesco S Celi; Oksana Gavrilova; Craig J Thomas; Bruce M Raaka; Marvin C Gershengorn
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12471-6.
2009: Lars Winkler; Claudia Gehring; Ariane Wenzel; Sebastian L Müller; Christian Piehl; Gerd Krause; Ingolf E Blasig; Jörg Piontek
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3.
The Journal of biological chemistry 2009;284(28):18863-72.
2009: Jens Lättig; Alexander Oksche; Michael Beyermann; Walter Rosenthal; Gerd Krause
Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(7):479-91.
2009: Christian Schillinger; Prisca Boisguerin; Gerd Krause
Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions.
Bioinformatics (Oxford, England) 2009;25(13):1632-9.
2009: Sandra Mueller; Gunnar Kleinau; Mariusz W Szkudlinski; Holger Jaeschke; Gerd Krause; Ralf Paschke
The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.
The Journal of biological chemistry 2009;284(24):16317-24.
2009: Gunnar Kleinau; Gerd Krause
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms.
Endocrine reviews 2009;30(2):133-51.
2009: Catherine L Worth; Gunnar Kleinau; Gerd Krause
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.
PloS one 2009;4(9):e7011.
2008: Holger Jaeschke; Gunnar Kleinau; J Sontheimer; Sandra Mueller; Gerd Krause; Ralf Paschke
Preferences of transmembrane helices for cooperative amplification of G(alpha)s and G (alpha)q signaling of the thyrotropin receptor.
Cellular and molecular life sciences : CMLS 2008;65(24):4028-38.
2008: Susanne Neumann; Gunnar Kleinau; Stefano Costanzi; Susanna Moore; Jian-kang Jiang; Bruce M Raaka; Craig J Thomas; Gerd Krause; Marvin C Gershengorn
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.
Endocrinology 2008;149(12):5945-50.
2008: Gunnar Kleinau; Holger Jaeschke; Sandra Mueller; C L Worth; Ralf Paschke; Gerd Krause
Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.
Cellular and molecular life sciences : CMLS 2008;65(22):3664-76.
2008: Gunnar Kleinau; Holger Jaeschke; Sandra Mueller; Bruce M Raaka; Susanne Neumann; Ralf Paschke; Gerd Krause
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2798-808.
2008: Sandra Mueller; Gunnar Kleinau; Holger Jaeschke; Ralf Paschke; Gerd Krause
Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.
The Journal of biological chemistry 2008;283(26):18048-55.
2008: Gerd Krause; Lars Winkler; Sebastian L Mueller; Reiner F Haseloff; Jörg Piontek; Ingolf E Blasig
Structure and function of claudins.
Biochimica et biophysica acta 2008;1778(3):631-45.
2008: Patrick Tarnow; Anne Rediger; Harald Brumm; Petra Ambrugger; Eva Rettenbacher; Kurt Widhalm; Anke Hinney; Gunnar Kleinau; Michael Schaefer; Johannes Hebebrand; Gerd Krause; Annette Grüters; Heike Biebermann
A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R.
Obesity facts 2008;1(3):155-62.
2008: Grit-Carsta Bulwin; Stephanie Wälter; Mirko Schlawinsky; Thomas Heinemann; Anke Schulze; Wolfgang Höhne; Gerd Krause; Wiltrud Kalka-Moll; Patricia Fraser; Hans-Dieter Volk; Jürgen Löhler; Edgar L Milford; Nalân Utku
HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.
PloS one 2008;3(2):e1576.
2008: Jörg Piontek; Lars Winkler; Hartwig Wolburg; Sebastian L Müller; Nikolaj Zuleger; Christian Piehl; Burkhard Wiesner; Gerd Krause; Ingolf E Blasig
Formation of tight junction: determinants of homophilic interaction between classic claudins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):146-58.
2007: Nadja Jung; Martin Wienisch; Mingyu Gu; James B Rand; Sebastian L Müller; Gerd Krause; Erik M Jorgensen; Jurgen Klingauf; Volker Haucke
Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2.
The Journal of cell biology 2007;179(7):1497-510.
2007: Kristin Pankow; Yong Wang; Florian Gembardt; Eberhard Krause; Xiaoou Sun; Gerd Krause; Heinz-Peter Schultheiss; Wolf-Eberhard Siems; Thomas Walther
Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide.
Circulation research 2007;101(9):875-82.
2007: Gunnar Kleinau; Mara Brehm; Urs Wiedemann; Dirk Labudde; Ulf Leser; Gerd Krause
Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):574-80.
2007: Gunnar Kleinau; Maren Claus; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2007;282(1):518-25.
2006: Christian Köhler; Olav M Andersen; Anne Diehl; Gerd Krause; Peter Schmieder; Hartmut Oschkinat
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.
Journal of structural and functional genomics 2006;7(3-4):131-8.
2006: Maren Claus; Susanne Neumann; Gunnar Kleinau; Gerd Krause; Ralf Paschke
Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor.
Journal of molecular medicine (Berlin, Germany) 2006;84(11):943-54.
2006: Neil Ferguson; Johanna Becker; Henning Tidow; Sandra Tremmel; Timothy D Sharpe; Gerd Krause; Jeremy Flinders; Miriana Petrovich; John Berriman; Hartmut Oschkinat; Alan Fersht
General structural motifs of amyloid protofilaments.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16248-53.
2006: Sandra Mueller; Gunnar Kleinau; Holger Jaeschke; Susanne Neumann; Gerd Krause; Ralf Paschke
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2006;281(42):31638-46.
2006: Susanna Moore; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Stefano Costanzi; Jian-Kang Jiang; John Childress; Bruce M Raaka; Anny-Odile Colson; Ralf Paschke; Gerd Krause; Craig J Thomas; Marvin C Gershengorn
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Journal of medicinal chemistry 2006;49(13):3888-96.
2006: Mangesh Joshi; Carolyn Vargas; Prisca Boisguerin; Anne Diehl; Gerd Krause; Peter Schmieder; Karin Moelling; Volker Hagen; Markus Schade; Hartmut Oschkinat
Discovery of low-molecular-weight ligands for the AF6 PDZ domain.
Angewandte Chemie (International ed. in English) 2006;45(23):3790-5.
2006: Christian Hundsrucker; Gerd Krause; Michael Beyermann; Anke Prinz; Bastian Zimmermann; Oliver Diekmann; Dorothea Lorenz; Eduard Stefan; Pavel I Nedvetsky; Margitta Dathe; Frank Christian; Theresa McSorley; Eberhard Krause; George McConnachie; Friedrich W Herberg; John D Scott; Walter Rosenthal; Enno Klussmann
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
The Biochemical journal 2006;396(2):297-306.
2006: Holger Jäschke; Susanne Neumann; Susanna Moore; Craig J Thomas; Anny-Odile Colson; Stefano Costanzi; Gunnar Kleinau; Jian-Kang Jiang; Ralf Paschke; Bruce M Raaka; Gerd Krause; Marvin C Gershengorn
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
The Journal of biological chemistry 2006;281(15):9841-4.
2006: Holger Jaeschke; Susanne Neumann; Gunnar Kleinau; Sandra Mueller; Maren Claus; Gerd Krause; Ralf Paschke
An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
Endocrinology 2006;147(4):1753-60.
2006: Ingolf E Blasig; Lars Winkler; B Lassowski; S L Mueller; N Zuleger; Eberhard Krause; Gerd Krause; K Gast; Michael Kolbe; Jörg Piontek
On the self-association potential of transmembrane tight junction proteins.
Cellular and molecular life sciences : CMLS 2006;63(4):505-14.
2005: Zhongjing Chen; Gerd Krause; Bernd Reif
Structure and orientation of peptide inhibitors bound to beta-amyloid fibrils.
Journal of molecular biology 2005;354(4):760-76.
2005: Maren Claus; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Gerd Krause; Ralf Paschke
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.
Endocrinology 2005;146(12):5197-203.
2005: Sorin Tunaru; Jens Lättig; Jukka Kero; Gerd Krause; Stefan Offermanns
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).
Molecular pharmacology 2005;68(5):1271-80.
2005: Anja Thielen; Morad Oueslati; Ricardo Hermosilla; Gerd Krause; Alexander Oksche; Walter Rosenthal; Ralf Schülein
The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding.
FEBS letters 2005;579(23):5227-35.
2005: Beate Karges; Gerd Krause; Janos Homoki; Klaus-Michael Debatin; Nicolas de Roux; Wolfram Karges
TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.
The Journal of endocrinology 2005;186(2):377-85.
2005: Dietmar Leitner; Michael Wahl; Dirk Labudde; Gerd Krause; Anne Diehl; Peter Schmieder; Juliana Rico Pires; Michele Fossi; Urs Wiedemann; Martina Leidert; Hartmut Oschkinat
The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology.
FEBS letters 2005;579(17):3534-8.
2005: Roland Kaufmann; Beate Schulze; Gerd Krause; Lorenz M Mayr; Utz Settmacher; Peter Henklein
Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1.
Regulatory peptides 2005;125(1-3):61-6.
2005: Sebastian L Müller; Michael Portwich; Anke Schmidt; Darkhan I Utepbergenov; Otmar Huber; Ingolf E Blasig; Gerd Krause
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1.
The Journal of biological chemistry 2005;280(5):3747-56.
2005: Susanne Neumann; Gerd Krause; Maren Claus; Ralf Paschke
Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.
Endocrinology 2005;146(1):477-85.
2004: Gunnar Kleinau; Holger Jäschke; Susanne Neumann; Jens Lättig; Ralf Paschke; Gerd Krause
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
The Journal of biological chemistry 2004;279(49):51590-600.
2004: Karin Schleinkofer; Urs Wiedemann; Livia Otte; Ting Wang; Gerd Krause; Hartmut Oschkinat; Rebecca C Wade
Comparative structural and energetic analysis of WW domain-peptide interactions.
Journal of molecular biology 2004;344(3):865-81.
2004: Stefan Wüller; Burkhard Wiesner; Anja Löffler; Jens Furkert; Gerd Krause; Ricardo Hermosilla; Michael Schaefer; Ralf Schülein; Walter Rosenthal; Alexander Oksche
Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.
The Journal of biological chemistry 2004;279(45):47254-63.
2004: Urs Wiedemann; Prisca Boisguerin; Rainer Leben; Dietmar Leitner; Gerd Krause; Karin Moelling; Rudolf Volkmer-Engert; Hartmut Oschkinat
Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides.
Journal of molecular biology 2004;343(3):703-18.
2004: Anke Schmidt; Darkhan I Utepbergenov; S L Mueller; M Beyermann; J Schneider-Mergener; Gerd Krause; Ingolf E Blasig
Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulation.
Cellular and molecular life sciences : CMLS 2004;61(11):1354-65.
2003: Livia Otte; Urs Wiedemann; Brigitte Schlegel; Juliana Rico Pires; Michael Beyermann; Peter Schmieder; Gerd Krause; Rudolf Volkmer-Engert; Jens Schneider-Mergener; Hartmut Oschkinat
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains.
Protein science : a publication of the Protein Society 2003;12(3):491-500.
2002: Robert Köchl; Martina Alken; Claudia Rutz; Gerd Krause; Alexander Oksche; Walter Rosenthal; Ralf Schülein
The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane.
The Journal of biological chemistry 2002;277(18):16131-8.
2002: Alexander Oksche; Gabriele Leder; Susanne Valet; Matthias Platzer; Kerstin Hasse; Soeren Geist; Gerd Krause; André Rosenthal; Walter Rosenthal
Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):799-813.
2002: Yasuyuki Fujita; Gerd Krause; Martin Scheffner; Dietmar Zechner; Hugo E Molina Leddy; Jürgen Behrens; Thomas Sommer; Walter Birchmeier
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Nature cell biology 2002;4(3):222-31.
2001: Anke Schmidt; Darkhan I Utepbergenov; Gerd Krause; Ingolf E Blasig
Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin.
Biochemical and biophysical research communications 2001;288(5):1194-9.
2001: Ingrid Monden; A Olsowski; Gerd Krause; Konrad Keller
The large cytoplasmic loop of the glucose transporter GLUT1 is an essential structural element for function.
Biological chemistry 2001;382(11):1551-8.
2001: Susanne Neumann; Gerd Krause; S Chey; Ralf Paschke
A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1294-305.
2001: A L Salmon; L J Cross; Alexandra E Irvine; Terence R J Lappin; Margitta Dathe; Gerd Krause; P Canning; L Thim; Michael Beyermann; Sven Rothemund; Michael Bienert; C Shaw
Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens.
The Journal of biological chemistry 2001;276(13):10145-52.
2001: Ralf Schülein; K Zühlke; Gerd Krause; Walter Rosenthal
Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation.
The Journal of biological chemistry 2001;276(11):8384-92.
2000: Angela Schulz; Karsten Bruns; Peter Henklein; Gerd Krause; Mario Schubert; Thomas Gudermann; Victor Wray; Günter Schultz; Torsten Schöneberg
Requirement of specific intrahelical interactions for stabilizing the inactive conformation of glycoprotein hormone receptors.
The Journal of biological chemistry 2000;275(48):37860-9.
2000: A Olsowski; Ingrid Monden; Gerd Krause; Konrad Keller
Cysteine scanning mutagenesis of helices 2 and 7 in GLUT1 identifies an exofacial cleft in both transmembrane segments.
Biochemistry 2000;39(10):2469-74.
2000: Gerd Krause; Ricardo Hermosilla; Alexander Oksche; Claudia Rutz; Walter Rosenthal; Ralf Schülein
Molecular and conformational features of a transport-relevant domain in the C-terminal tail of the vasopressin V(2) receptor.
Molecular pharmacology 2000;57(2):232-42.
1999: Elzbieta Kojro; Rolf Postina; Sandra Gilbert; F Bender; Gerd Krause; Falk Fahrenholz
Structural requirements for V2 vasopressin receptor proteolytic cleavage.
European journal of biochemistry / FEBS 1999;266(2):538-48.
1999: M Smalla; Peter Schmieder; M Kelly; Antonius Marinus ter Laak; Gerd Krause; L Ball; Michael Wahl; P Bork; Hartmut Oschkinat
Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites.
Protein science : a publication of the Protein Society 1999;8(10):1954-61.
1998: Heike Biebermann; Torsten Schöneberg; Angela Schulz; Gerd Krause; Annette Grüters; Günter Schultz; Thomas Gudermann
A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(14):1461-71.
1998: Ralf Schülein; Ricardo Hermosilla; Alexander Oksche; M Dehe; Burkhard Wiesner; Gerd Krause; Walter Rosenthal
A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells.
Molecular pharmacology 1998;54(3):525-35.
1998: F Horn; R Bywater; Gerd Krause; W Kuipers; L Oliveira; A C Paiva; Chris Sander; G Vriend
The interaction of class B G protein-coupled receptors with their hormones.
Receptors & channels 1998;5(5):305-14.
1998: J Schultz; U Hoffmüller; Gerd Krause; J Ashurst; Maria J Macias; P Schmieder; Jens Schneider-Mergener; Hartmut Oschkinat
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels.
Nature structural biology 1998;5(1):19-24.
1995: L J Cross; Madeleine Ennis; Eberhard Krause; Margitta Dathe; D Lorenz; Gerd Krause; M Beyermann; Michael Bienert
Influence of alpha-helicity, amphipathicity and D-amino acid incorporation on the peptide-induced mast cell activation.
European journal of pharmacology 1995;291(3):291-300.
1995: Sven Rothemund; M Beyermann; Eberhard Krause; Gerd Krause; Michael Bienert; R S Hodges; B D Sykes; F D Sönnichsen
Structure effects of double D-amino acid replacements: a nuclear magnetic resonance and circular dichroism study using amphipathic model helices.
Biochemistry 1995;34(40):12954-62.
1980: Gerd Krause; W J Streich; R Franke
Informational content of discrete data from parallel test with similar biological objects: selection of key tests.
Die Pharmazie 1980;35(8):488-94.