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Peter Breuer

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Mouse

Genes & Molecular Sequences

Anatomy

Phenomena

Protein Binding

Physiology

Mutation

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Publications

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Philipp Koch; Per Hoffmann; Ullrich Wüllner; Julia Ladewig; Jonas Doerr; Bernd O Evert; Johannes Jungverdorben; Jaideep Kesavan; Peter Breuer; Daniel Poppe; Michael Peitz; Thomas Klockgether; Thomas Tüting; Jerome Mertens; Oliver Brüstle
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Julieta Araujo; Peter Breuer; Susanne Dieringer; Stephanie Dorn; Thomas Klockgether; Sybille Krauss; Alexander Pfeifer; Ullrich Wüllner; Katrin Zimmermann; Bernd Evert
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Peter Breuer; Annette Haacke; Bernd Evert; Ullrich Wüllner
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.

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All Publications

2011: Philipp Koch; Per Hoffmann; Ullrich Wüllner; Julia Ladewig; Jonas Doerr; Bernd O Evert; Johannes Jungverdorben; Jaideep Kesavan; Peter Breuer; Daniel Poppe; Michael Peitz; Thomas Klockgether; Thomas Tüting; Jerome Mertens; Oliver Brüstle
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Nature 2011;480(7378):543-6.
2011: Julieta Araujo; Peter Breuer; Susanne Dieringer; Stephanie Dorn; Thomas Klockgether; Sybille Krauss; Alexander Pfeifer; Ullrich Wüllner; Katrin Zimmermann; Bernd Evert
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Human molecular genetics 2011;20(15):2928-41.
2010: Peter Breuer; Annette Haacke; Bernd Evert; Ullrich Wüllner
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
The Journal of biological chemistry 2010;285(9):6532-7.
2009: Thorsten Mueller; Peter Breuer; Ina Schmitt; Jochen Walter; Bernd Evert; Ullrich Wüllner
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Human molecular genetics 2009;18(17):3334-43.
2007: Ina Schmitt; Marion Linden; Hassan Khazneh; Bernd Evert; Peter Breuer; Thomas Klockgether; Ullrich Wüllner
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Biochemical and biophysical research communications 2007;362(3):734-9.
2007: Nikolay Tzvetkov; Peter Breuer
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Biological chemistry 2007;388(9):973-8.
2007: Annette Haacke; F Ulrich Hartl; Peter Breuer
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
The Journal of biological chemistry 2007;282(26):18851-6.
2006: Annett Boeddrich; Sébastien Gaumer; Annette Haacke; Nikolay Tzvetkov; Mario Albrecht; Bernd Evert; Eva-Christina Müller; Rudi Lurz; Peter Breuer; Nancy Schugardt; Stephanie Plassmann; Kexiang Xu; John M Warrick; Jaana Suopanki; Ullrich Wüllner; Ronald Frank; Ulrich F Hartl; Nancy M Bonini; Erich E Wanker
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
The EMBO journal 2006;25(7):1547-58.
2006: Annette Haacke; Sarah A Broadley; Raina Boteva; Nikolay Tzvetkov; F Ulrich Hartl; Peter Breuer
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
Human molecular genetics 2006;15(4):555-68.
2006: Nikolay Tzvetkov; Peter Breuer; Raina Boteva
Cysteine-free glutathione-S-tranferase as a tool for thiol-specific labeling of proteins.
BioTechniques 2006;40(2):145-6.
2004: Gregor Schaffar; Peter Breuer; Raina Boteva; Christian Behrends; Nikolay Tzvetkov; Nadine Strippel; Hideki Sakahira; Katja Siegers; Manajit Hayer-Hartl; F Ulrich Hartl
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Molecular cell 2004;15(1):95-105.
2002: Hideki Sakahira; Peter Breuer; Manajit Hayer-Hartl; F Ulrich Hartl
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16412-8.
1998: Peter Breuer; Thomas Braulke
Stabilization of mutant 46-kDa mannose 6-phosphate receptors by proteasomal inhibitor lactacystin.
The Journal of biological chemistry 1998;273(50):33254-8.
1998: P Putzer; Peter Breuer; Werner Götz; M Gross; Bernd Kübler; Jens-Gerd Scharf; A G Schuller; H Hartmann; Thomas Braulke
Mouse insulin-like growth factor binding protein-6: expression, purification, characterization and histochemical localization.
Molecular and cellular endocrinology 1998;137(1):69-78.
1997: Peter Breuer; Christian Körner; C Böker; A Herzog; Regina Pohlmann; Thomas Braulke
Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells.
Molecular biology of the cell 1997;8(4):567-76.