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Paul Hollenberg

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Yasushi Yoshigae; Ute M Kent; Chitra Sridar; Paul Hollenberg
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.
Haoming Zhang; Qinghai Zhang; Maryam Foroozesh; Sean C Gay; James R Halpert; Jiawang Liu; Yoichi Osawa; Manish Shah; C David Stout; Paul Hollenberg
Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.
Cesar Kenaan; Hsia-lien Lin; Matthew J Pratt-Hyatt; Erin V Shea; Haoming Zhang; Paul Hollenberg
Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.

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All Publications

2013: Yasushi Yoshigae; Ute M Kent; Chitra Sridar; Paul Hollenberg
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(4):858-69.
2013: Haoming Zhang; Qinghai Zhang; Maryam Foroozesh; Sean C Gay; James R Halpert; Jiawang Liu; Yoichi Osawa; Manish Shah; C David Stout; Paul Hollenberg
Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.
Biochemistry 2013;52(2):355-64.
2013: Cesar Kenaan; Hsia-lien Lin; Matthew J Pratt-Hyatt; Erin V Shea; Haoming Zhang; Paul Hollenberg
Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):101-10.
2012: Hsia-lien Lin; Haoming Zhang; Cesar Kenaan; Paul Hollenberg
Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase.
Chemical research in toxicology 2012;25(12):2642-53.
2012: Chitra Sridar; Jaime D'Agostino; Paul Hollenberg
Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(12):2280-8.
2012: Chitra Sridar; Cesar Kenaan; Paul Hollenberg
Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(12):2256-66.
2012: Krishna C Chimalakonda; Gregory W Endres; Paul Hollenberg; Laura P James; Cindy L Moran; Stacie Bratton; Lisa K Brents; Paul L Prather; Anna Radominska-Pandya; Kathryn A Seely; Jeffery H Moran
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(11):2174-84.
2012: Hemali T Amunugama; Haoming Zhang; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(9):1765-70.
2012: Haoming Zhang; Wei C Lau; Paul Hollenberg
Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes.
Molecular pharmacology 2012;82(2):302-9.
2012: Hsia-lien Lin; Cesar Kenaan; Paul Hollenberg
Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(5):998-1006.
2011: Hsia-lien Lin; Matthew J Pratt-Hyatt; Haoming Zhang; Paul Hollenberg
Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2431-9.
2011: Haoming Zhang; Sarah Ney; Hemali Amunugama; Nyemade Cooper; Paul Hollenberg
Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
Molecular pharmacology 2011;80(5):839-47.
2011: Haoming Zhang; Hemali Amunugama; David P Ballou; Cesar Kenaan; Chitra Sridar; Paul Hollenberg
Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex.
The Journal of pharmacology and experimental therapeutics 2011;338(3):803-9.
2011: Sean C Gay; Haoming Zhang; Paul Wilderman; Arthur G Roberts; Tong Liu; Sheng Li; Hsia-lien Lin; Qinghai Zhang; Virgil L Woods; C David Stout; Paul Hollenberg; James R Halpert
Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.
Biochemistry 2011;50(22):4903-11.
2011: Cesar Kenaan; Haoming Zhang; Erin V Shea; Paul Hollenberg
Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions.
Biochemistry 2011;50(19):3957-67.
2011: Chitra Sridar; Natasha T Snider; Paul Hollenberg
Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):782-8.
2011: Haoming Zhang; Hsia-lien Lin; Cesar Kenaan; Paul Hollenberg
Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes.
Archives of biochemistry and biophysics 2011;507(1):135-43.
2011: Hsia-lien Lin; Haoming Zhang; Christine Medower; Paul Hollenberg; William W Johnson
Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(2):345-50.
2010: Matthew Pratt-Hyatt; Hsia-lien Lin; Paul Hollenberg
Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(12):2286-92.
2010: Matthew Pratt-Hyatt; Haoming Zhang; Natasha T Snider; Paul Hollenberg
Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(11):2075-82.
2010: Cesar Kenaan; Haoming Zhang; Paul Hollenberg
A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.
Nature protocols 2010;5(10):1652-8.
2010: Hsia-lien Lin; Haoming Zhang; Monica Jushchyshyn; Paul Hollenberg
Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene.
The Journal of pharmacology and experimental therapeutics 2010;333(3):663-9.
2010: Hyun-Hee Jang; Arvind P Jamakhandi; Shane Z Sullivan; Chul-Ho Yun; Paul Hollenberg; Grover P Miller
Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.
Biochimica et biophysica acta 2010;1804(6):1285-93.
2010: Namandjé N Bumpus; Paul Hollenberg
Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction.
Journal of inorganic biochemistry 2010;104(4):485-8.
2010: Shinichiro Hanada; Natasha T Snider; Elizabeth M Brunt; Paul Hollenberg; M Bishr Omary
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress.
Gastroenterology 2010;138(4):1607-17.
2010: Natasha T Snider; Vyvyca J Walker; Paul Hollenberg
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.
Pharmacological reviews 2010;62(1):136-54.
2010: Paul Hollenberg
Introduction: mechanisms of metal toxicity special issue.
Chemical research in toxicology 2010;23(2):292-3.
2010: Piotr J Mak; Haoming Zhang; Paul Hollenberg; James R Kincaid
Defining the structural consequences of mechanism-based inactivation of mammalian cytochrome P450 2B4 using resonance Raman spectroscopy.
Journal of the American Chemical Society 2010;132(5):1494-5.
2009: Haoming Zhang; Hsia-lien Lin; Vyvyca J Walker; Djemel Hamdane; Paul Hollenberg
tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance.
Molecular pharmacology 2009;76(5):1011-8.
2009: Hsia-lien Lin; Haoming Zhang; Kathleen R Noon; Paul Hollenberg
Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.
The Journal of pharmacology and experimental therapeutics 2009;331(2):392-403.
2009: Haoming Zhang; Cesar Kenaan; Djemel Hamdane; Gaston Hui Bon Hoa; Paul Hollenberg
Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1.
The Journal of biological chemistry 2009;284(38):25678-86.
2009: Natasha T Snider; James A Nast; Laura A Tesmer; Paul Hollenberg
A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist.
Molecular pharmacology 2009;75(4):965-72.
2009: Hsia-lien Lin; Haoming Zhang; Paul Hollenberg
Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
The Journal of pharmacology and experimental therapeutics 2009;329(1):26-37.
2009: Mohamad Shebley; Ute M Kent; David P Ballou; Paul Hollenberg
Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):745-52.
2009: Xin Sheng; Haoming Zhang; Sang Choul Im; John H Horner; Lucy Waskell; Paul Hollenberg; Martin E. Newcomb
Kinetics of oxidation of benzphetamine by compounds I of cytochrome P450 2B4 and its mutants.
Journal of the American Chemical Society 2009;131(8):2971-6.
2009: Xin Sheng; Haoming Zhang; Paul Hollenberg; Martin E. Newcomb
Kinetic isotope effects in hydroxylation reactions effected by cytochrome P450 compounds I implicate multiple electrophilic oxidants for P450-catalyzed oxidations.
Biochemistry 2009;48(7):1620-7.
2008: Natasha T Snider; Matthew J Sikora; Chitra Sridar; Thomas J Feuerstein; James M Rae; Paul Hollenberg
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.
The Journal of pharmacology and experimental therapeutics 2008;327(2):538-45.
2008: Chitra Sridar; Ute M Kent; Kathleen R Noon; Alecia McCall; Bill Alworth; Mahtab B Foroozesh; Paul Hollenberg
Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2234-43.
2008: Ute M Kent; Chitra Sridar; Greg Spahlinger; Paul Hollenberg
Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.
Chemical research in toxicology 2008;21(10):1956-63.
2008: Namandjé N Bumpus; Paul Hollenberg
Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity.
Molecular pharmacology 2008;74(4):990-9.
2008: Djemel Hamdane; Haoming Zhang; Paul Hollenberg
Oxygen activation by cytochrome P450 monooxygenase.
Photosynthesis research 2008;98(1-3):657-66.
2008: Paul Hollenberg; Ute M Kent; Namandjé N Bumpus
Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.
Chemical research in toxicology 2008;21(1):189-205.
2007: Hsia-lien Lin; Eugene Myshkin; Lucy Waskell; Paul Hollenberg
Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.
Chemical research in toxicology 2007;20(11):1612-22.
2007: Linda B von Weymarn; Jamie A Chun; Gabriel A Knudsen; Paul Hollenberg
Effects of eleven isothiocyanates on P450 2A6- and 2A13-catalyzed coumarin 7-hydroxylation.
Chemical research in toxicology 2007;20(9):1252-9.
2007: Mohamad Shebley; Paul Hollenberg
Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(8):1365-71.
2007: Natasha T Snider; Andrei M Kornilov; Ute M Kent; Paul Hollenberg
Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides.
The Journal of pharmacology and experimental therapeutics 2007;321(2):590-7.
2007: Hsia-lien Lin; Paul Hollenberg
The inactivation of cytochrome P450 3A5 by 17alpha-ethynylestradiol is cytochrome b5-dependent: metabolic activation of the ethynyl moiety leads to the formation of glutathione conjugates, a heme adduct, and covalent binding to the apoprotein.
The Journal of pharmacology and experimental therapeutics 2007;321(1):276-87.
2007: Edith J Mensah-Osman; Dafydd Thomas; Michelle M Tabb; Jose M Larios; Dennis P M Hughes; Thomas J Giordano; Michelle L Lizyness; James M Rae; Bruce Blumberg; Paul Hollenberg; Laurence H Baker
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.
Cancer 2007;109(5):957-65.
2007: Martin E. Newcomb; Dharmika S P Lansakara-P; Hye-Yeong Kim; Ranepuradewage Chandrasena; Stephen J Lippard; Laurance G Beauvais; Leslie J Murray; Viviana Izzo; Paul Hollenberg; Minor J Coon
Products from enzyme-catalyzed oxidations of norcarenes.
The Journal of organic chemistry 2007;72(4):1128-33.
2007: Martin E. Newcomb; Ranepuradewage Chandrasena; Dharmika S P Lansakara-P; Hye-Yeong Kim; Stephen J Lippard; Laurance G Beauvais; Leslie J Murray; Viviana Izzo; Paul Hollenberg; Minor J Coon
Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane.
The Journal of organic chemistry 2007;72(4):1121-7.
2006: Yoshimasa Kobayashi; Chitra Sridar; Ute M Kent; Satish G Puppali; John M Rimoldi; Haoming Zhang; Lucy Waskell; Paul Hollenberg
Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):2102-10.
2006: Chitra Sridar; Yoshimasa Kobayashi; Holly Brevig; Ute M Kent; Satish G Puppali; John M Rimoldi; Paul Hollenberg
Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(11):1849-55.
2006: Ute M Kent; Hsia-lien Lin; Kathleen R Noon; Danni L Harris; Paul Hollenberg
Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.
The Journal of pharmacology and experimental therapeutics 2006;318(3):992-1005.
2006: Monica I Jushchyshyn; Jan L Wahlstrom; Paul Hollenberg; Larry C Wienkers
Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1523-9.
2006: Namandjé N Bumpus; Ute M Kent; Paul Hollenberg
Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms.
The Journal of pharmacology and experimental therapeutics 2006;318(1):345-51.
2006: Linda B von Weymarn; Jamie A Chun; Paul Hollenberg
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
Carcinogenesis 2006;27(4):782-90.
2006: Mohamad Shebley; Monica I Jushchyshyn; Paul Hollenberg
Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(3):375-83.
2006: Ute M Kent; Hsia-lien Lin; Danielle E Mills; Kelly A Regal; Paul Hollenberg
Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
Chemical research in toxicology 2006;19(2):279-87.
2005: Yoshihiro Morishima; Hwei-Ming Peng; Hsia-lien Lin; Paul Hollenberg; Roger K Sunahara; Yoichi Osawa; William B Pratt
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.
Biochemistry 2005;44(49):16333-40.
2005: Chitra Sridar; Erin Harleton; Paul Hollenberg
Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism.
Biochemical and biophysical research communications 2005;338(1):386-93.
2005: Hsia-lien Lin; Haoming Zhang; Lucy Waskell; Paul Hollenberg
The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1.
Chemical research in toxicology 2005;18(8):1203-10.
2005: Namandjé N Bumpus; Chitra Sridar; Ute M Kent; Paul Hollenberg
The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(6):795-802.
2005: Hsia-lien Lin; Ute M Kent; Paul Hollenberg
The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
The Journal of pharmacology and experimental therapeutics 2005;313(1):154-64.
2005: Anna L Blobaum; Danni L Harris; Paul Hollenberg
P450 active site architecture and reversibility: inactivation of cytochromes P450 2B4 and 2B4 T302A by tert-butyl acetylenes.
Biochemistry 2005;44(10):3831-44.
2005: Linda B von Weymarn; Qing-Yu Zhang; Xinxin Ding; Paul Hollenberg
Effects of 8-methoxypsoralen on cytochrome P450 2A13.
Carcinogenesis 2005;26(3):621-9.
2005: Mehul N Bhakta; Paul Hollenberg; Kandatege Wimalasena
P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct.
Journal of the American Chemical Society 2005;127(5):1376-7.
2005: Mehul N Bhakta; Paul Hollenberg; Kandatege Wimalasena
Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations.
Chemical communications (Cambridge, England) 2005;(2):265-7.
2004: Theunis C Goosen; Doré Cillié; David G Bailey; Chongwoo Yu; Kan He; Paul Hollenberg; Patrick M Woster; Lucinda Cohen; J Andrew Williams; Malie Rheeders; H Paul Dijkstra
Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans.
Clinical pharmacology and therapeutics 2004;76(6):607-17.
2004: Hsia-lien Lin; Ute M Kent; Haoming Zhang; Lucy Waskell; Paul Hollenberg
The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.
The Journal of pharmacology and experimental therapeutics 2004;311(3):855-63.
2004: Linda B von Weymarn; Chitra Sridar; Paul Hollenberg
Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.
The Journal of pharmacology and experimental therapeutics 2004;311(1):71-9.
2004: Anna L Blobaum; Yipin Lu; Ute M Kent; Shaomeng Wang; Paul Hollenberg
Formation of a novel reversible cytochrome P450 spectral intermediate: role of threonine 303 in P450 2E1 inactivation.
Biochemistry 2004;43(38):11942-52.
2004: Erin Harleton; Marie Webster; Namandjé N Bumpus; Ute M Kent; James M Rae; Paul Hollenberg
Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1011-9.
2004: Anna L Blobaum; Ute M Kent; William L Alworth; Paul Hollenberg
Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1.
The Journal of pharmacology and experimental therapeutics 2004;310(1):281-90.
2004: Chitra Sridar; Theunis C Goosen; Ute M Kent; J Andrew Williams; Paul Hollenberg
Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):587-94.
2004: Linda B von Weymarn; Anna L Blobaum; Paul Hollenberg
The mechanism-based inactivation of p450 2B4 by tert-butyl 1-methyl-2-propynyl ether: structural determination of the adducts to the p450 heme.
Archives of biochemistry and biophysics 2004;425(1):95-105.
2004: Ute M Kent; Lise Pascual; Rebecca A Roof; David P Ballou; Paul Hollenberg
Mechanistic studies with N-benzyl-1-aminobenzotriazole-inactivated CYP2B1: differential effects on the metabolism of 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, and benzphetamine.
Archives of biochemistry and biophysics 2004;423(2):277-87.
2004: Ranepuradewage Chandrasena; Kostas P Vatsis; Minor J Coon; Paul Hollenberg; Martin E. Newcomb
Hydroxylation by the hydroperoxy-iron species in cytochrome P450 enzymes.
Journal of the American Chemical Society 2004;126(1):115-26.
2003: James R Reed; Paul Hollenberg
New perspectives on the conformational equilibrium regulating multi-phasic reduction of cytochrome P450 2B4 by cytochrome P450 reductase.
Journal of inorganic biochemistry 2003;97(3):276-86.
2003: James R Reed; Paul Hollenberg
Examining the mechanism of stimulation of cytochrome P450 by cytochrome b5: the effect of cytochrome b5 on the interaction between cytochrome P450 2B4 and P450 reductase.
Journal of inorganic biochemistry 2003;97(3):265-75.
2003: Hsia-lien Lin; Haoming Zhang; Lucy Waskell; Paul Hollenberg
Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation.
The Journal of pharmacology and experimental therapeutics 2003;306(2):744-51.
2003: Hassan R Dhaini; Dafydd Thomas; Thomas J Giordano; Timothy D Johnson; J Sybil Biermann; Kirsten M Leu; Paul Hollenberg; Laurence H Baker
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(13):2481-5.
2003: Martin E. Newcomb; David Aebisher; Runnan Shen; Ranepuradewage Chandrasena; Paul Hollenberg; Minor J Coon
Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations.
Journal of the American Chemical Society 2003;125(20):6064-5.
2003: Hsia-lien Lin; Ute M Kent; Haoming Zhang; Lucy Waskell; Paul Hollenberg
Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.
Chemical research in toxicology 2003;16(2):129-36.
2003: James R Reed; Paul Hollenberg
Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5.
Journal of inorganic biochemistry 2003;93(3-4):152-60.
2003: Monica I Jushchyshyn; Ute M Kent; Paul Hollenberg
The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(1):46-52.
2003: Martin E. Newcomb; Paul Hollenberg; Minor J Coon
Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations.
Archives of biochemistry and biophysics 2003;409(1):72-9.
2002: Anna L Blobaum; Ute M Kent; William L Alworth; Paul Hollenberg
Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
Chemical research in toxicology 2002;15(12):1561-71.
2002: Jennifer L Vuletich; Ezra R Lowe; Suree Jianmongkol; Yasuhiko Kamada; Ute M Kent; Andrew T Bender; Damon R Demady; Paul Hollenberg; Yoichi Osawa
Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo.
Molecular pharmacology 2002;62(1):110-8.
2002: Martin E. Newcomb; Runnan Shen; Yun Lu; Minor J Coon; Paul Hollenberg; Daniel A Kopp; Stephen J Lippard
Evaluation of norcarane as a probe for radicals in cytochome p450- and soluble methane monooxygenase-catalyzed hydroxylation reactions.
Journal of the American Chemical Society 2002;124(24):6879-86.
2002: Chitra Sridar; Ute M Kent; Lisa M Notley; Elizabeth M J Gillam; Paul Hollenberg
Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.
The Journal of pharmacology and experimental therapeutics 2002;301(3):945-52.
2002: Ute M Kent; Michael Aviram; Mira Rosenblat; Paul Hollenberg
The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):709-15.
2002: Hsia-lien Lin; Ute M Kent; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
The Journal of pharmacology and experimental therapeutics 2002;301(1):160-7.
2002: Paul Hollenberg
Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes.
Drug metabolism reviews 2002;34(1-2):17-35.
2002: Ute M Kent; Danielle E Mills; Rajendram V Rajnarayanan; William L Alworth; Paul Hollenberg
Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
The Journal of pharmacology and experimental therapeutics 2002;300(2):549-58.
2001: Ute M Kent; M I Juschyshyn; Paul Hollenberg
Mechanism-based inactivators as probes of cytochrome P450 structure and function.
Current drug metabolism 2001;2(3):215-43.
2001: R L Moreno; Theunis C Goosen; Ute M Kent; F L Chung; Paul Hollenberg
Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.
Archives of biochemistry and biophysics 2001;391(1):99-110.
2001: Ute M Kent; Elizabeth S Roberts-Kirchhoff; Namdoo Moon; W Richard Dunham; Paul Hollenberg
Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1.
Biochemistry 2001;40(24):7253-61.
2001: H Lin ; Paul Hollenberg
N-nitrosodimethylamine-mediated formation of oxidized and methylated dna bases in a cytochrome P450 2E1 expressing cell line.
Chemical research in toxicology 2001;14(5):562-6.
2001: John F Teiber; K Macé; Paul Hollenberg
Metabolism of the beta-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-beta-hydroxypropylpropylamine and N-nitroso-beta-oxopropylpropylamine.
Carcinogenesis 2001;22(3):499-506.
2001: H Kim; David A Putt; Richard C Zangar; C R Wolf; F P Guengerich; R J Edwards; Paul Hollenberg; Raymond F Novak
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(3):353-60.
2001: Theunis C Goosen; Danielle E Mills; Paul Hollenberg
Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.
The Journal of pharmacology and experimental therapeutics 2001;296(1):198-206.
2000: Theunis C Goosen; Ute M Kent; L Brand; Paul Hollenberg
Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables.
Chemical research in toxicology 2000;13(12):1349-59.
2000: John F Teiber; Paul Hollenberg
Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
Carcinogenesis 2000;21(8):1559-66.
2000: J Chun; Ute M Kent; R M Moss; L M Sayre; Paul Hollenberg
Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):905-11.
2000: St G Yanev; Ute M Kent; ES Roberts; David P Ballou; Paul Hollenberg
Mechanistic studies of cytochrome P450 2B1 inactivation by xanthates.
Archives of biochemistry and biophysics 2000;378(1):157-66.
2000: K A Regal; Michael L Schrag; Ute M Kent; Larry C Wienkers; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry.
Chemical research in toxicology 2000;13(4):262-70.
2000: Imad H Hanna; James R Reed; F Peter Guengerich; Paul Hollenberg
Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver.
Archives of biochemistry and biophysics 2000;376(1):206-16.
2000: James R Reed; M D Kraft; Paul Hollenberg
Rat liver cytosol catalyzes a reaction involving activated N-nitrosodimethylamine and a carbohydrate from the pentose phosphate pathway.
Chemical research in toxicology 2000;13(2):126-33.
1999: Elizabeth S Roberts-Kirchhoff; J R Crowley; Paul Hollenberg; H Kim
Metabolism of genistein by rat and human cytochrome P450s.
Chemical research in toxicology 1999;12(7):610-6.
1999: R L Moreno; Ute M Kent; K Hodge; Paul Hollenberg
Inactivation of cytochrome P450 2E1 by benzyl isothiocyanate.
Chemical research in toxicology 1999;12(7):582-7.
1999: SM Strobel; Grazyna D Szklarz; Y He; Mahtab B Foroozesh; William L Alworth; ES Roberts; Paul Hollenberg; James Halpert
Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.
The Journal of pharmacology and experimental therapeutics 1999;290(1):445-51.
1999: Hsia-lien Lin; Leslie A Parsels; Jonathan Maybaum; Paul Hollenberg
N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptotic cell death.
Toxicology and applied pharmacology 1999;157(2):117-24.
1999: A P Armstrong; Paul Hollenberg
Mechanism-based inactivation of rat liver cytochrome P-450 2B1 by 2-methoxy-5-nitrobenzyl bromide.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):741-5.
1999: St G Yanev; Ute M Kent; B Pandova; Paul Hollenberg
Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(5):600-4.
1999: Michael Aviram; U M Kent; Paul Hollenberg
Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein.
Atherosclerosis 1999;143(2):253-60.
1999: Ute M Kent; St G Yanev; Paul Hollenberg
Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by n-propylxanthate.
Chemical research in toxicology 1999;12(4):317-22.
1999: K He; Thomas Woolf; Paul Hollenberg
Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486).
The Journal of pharmacology and experimental therapeutics 1999;288(2):791-7.
1998: Ute M Kent; ES Roberts; J Chun; K Hodge; J Juncaj; Paul Hollenberg
Inactivation of cytochrome P450 2E1 by tert-butylisothiocyanate.
Chemical research in toxicology 1998;11(10):1154-61.
1998: ES Roberts; H l Lin; J R Crowley; Jennifer L Vuletich; Yoichi Osawa; Paul Hollenberg
Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.
Chemical research in toxicology 1998;11(9):1067-74.
1998: ES Roberts; William L Alworth; Paul Hollenberg
Mechanism-based inactivation of cytochromes P450 2E1 and 2B1 by 5-phenyl-1-pentyne.
Archives of biochemistry and biophysics 1998;354(2):295-302.
1998: Kan He; K R Iyer; RN Hayes; MW Sinz; Thomas Woolf; Paul Hollenberg
Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice.
Chemical research in toxicology 1998;11(4):252-9.
1998: I H Hanna; John F Teiber; K L Kokones; Paul Hollenberg
Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.
Archives of biochemistry and biophysics 1998;350(2):324-32.
1998: Hsia-lien Lin; ES Roberts; Paul Hollenberg
Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine.
Carcinogenesis 1998;19(2):321-9.
1998: I H Hanna; ES Roberts; Paul Hollenberg
Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2.
Biochemistry 1998;37(1):311-8.
1997: ES Roberts; N E Hopkins; Mahtab B Foroozesh; William L Alworth; James Halpert; Paul Hollenberg
Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1242-8.
1997: Phyllissa Schmiedlin-Ren; David J Edwards; M E Fitzsimmons; Kan He; Kenneth S Lown; Patrick M Woster; A Rahman; Kenneth E Thummel; Jeannine M Fisher; Paul Hollenberg; Paul B Watkins
Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1228-33.
1997: Ute M Kent; I H Hanna; Grazyna D Szklarz; AD Vaz; James Halpert; J R Bend; Paul Hollenberg
Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1.
Biochemistry 1997;36(39):11707-16.
1997: Ute M Kent; J R Bend; B A Chamberlin; DA Gage; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 2B1 by N-benzyl-1-aminobenzotriazole.
Chemical research in toxicology 1997;10(5):600-8.
1997: Liming Shu; Paul Hollenberg
Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1.
Carcinogenesis 1997;18(4):801-10.
1997: U Sharma; ES Roberts; Ute M Kent; S M Owens; Paul Hollenberg
Metabolic inactivation of cytochrome P4502B1 by phencyclidine: immunochemical and radiochemical analyses of the protective effects of glutathione.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(2):243-50.
1996: L E Beebe; ES Roberts; L W Fornwald; Paul Hollenberg; William L Alworth
Mechanism-based inhibition of mouse P4502b-10 by selected arylalkynes.
Biochemical pharmacology 1996;52(10):1507-13.
1996: U Sharma; ES Roberts; Paul Hollenberg
Formation of a metabolic intermediate complex of cytochrome P4502B1 by clorgyline.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(11):1247-53.
1996: ES Roberts; S J Pernecky; William L Alworth; Paul Hollenberg
A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene.
Archives of biochemistry and biophysics 1996;331(2):170-6.
1996: U Sharma; ES Roberts; Paul Hollenberg
Inactivation of cytochrome P4502B1 by the monoamine oxidase inhibitors R-(-)-deprenyl and clorgyline.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(6):669-75.
1996: Liming Shu; Paul Hollenberg
Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-,N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine.
Carcinogenesis 1996;17(4):839-48.
1996: D Ahn; David A Putt; Laura Kresty; G D Stoner; David Fromm; Paul Hollenberg
The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes.
Carcinogenesis 1996;17(4):821-8.
1996: Liming Shu; Paul Hollenberg
Role of cytochrome P450 in DNA damage induced by N-nitrosodialkylamines in cultured rat hepatocytes.
Carcinogenesis 1996;17(3):569-76.
1995: ES Roberts; David P Ballou; N E Hopkins; William L Alworth; Paul Hollenberg
Mechanistic studies of 9-ethynylphenanthrene-inactivated cytochrome P450 2B1.
Archives of biochemistry and biophysics 1995;323(2):303-12.
1995: ES Roberts; N E Hopkins; E J Zaluzec; D A Gage; William L Alworth; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 2B1 by 9-ethynylphenanthrene.
Archives of biochemistry and biophysics 1995;323(2):295-302.
1995: J R Crowley; Paul Hollenberg
Mechanism-based inactivation of rat liver cytochrome P4502B1 by phencyclidine and its oxidative product, the iminium ion.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(8):786-93.
1995: David A Putt; X Ding; M J Coon; Paul Hollenberg
Metabolism of aflatoxin B1 by rabbit and rat nasal mucosa microsomes and purified cytochrome P450, including isoforms 2A10 and 2A11.
Carcinogenesis 1995;16(6):1411-7.
1994: J K Atkinson; Paul Hollenberg; Keith U Ingold; C C Johnson; M H Le Tadic; Martin E. Newcomb; David A Putt
Cytochrome P450-catalyzed hydroxylation of hydrocarbons: kinetic deuterium isotope effects for the hydroxylation of an ultrafast radical clock.
Biochemistry 1994;33(35):10630-7.
1994: S C Kuemmerle; T Shen; Paul Hollenberg
Inactivation of purified rat liver cytochrome P-450 2B1 and rabbit liver cytochrome P-450 2B4 by N-methylcarbazole.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(3):343-51.
1994: ES Roberts; N E Hopkins; E J Zaluzec; D A Gage; William L Alworth; Paul Hollenberg
Identification of active-site peptides from 3H-labeled 2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry.
Biochemistry 1994;33(12):3766-71.
1994: T Shen; Paul Hollenberg
The mechanism of stimulation of NADPH oxidation during the mechanism-based inactivation of cytochrome P450 2B1 by N-methylcarbazole: redox cycling and DNA scission.
Chemical research in toxicology 1994;7(2):231-8.
1994: S S Mattano; Paul Hollenberg
The effect of cytosol on liver microsomal metabolic activation and demethylation of N-nitrosodimethylamine.
Chemical research in toxicology 1994;7(1):9-14.
1993: H Kim; David A Putt; S Reddy; Paul Hollenberg; Raymond F Novak
Enhanced expression of rat hepatic CYP2B1/2B2 and 2E1 by pyridine: differential induction kinetics and molecular basis of expression.
The Journal of pharmacology and experimental therapeutics 1993;267(2):927-36.
1993: ES Roberts; N E Hopkins; William L Alworth; Paul Hollenberg
Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: identification of an active-site peptide.
Chemical research in toxicology 1993;6(4):470-9.
1992: Paul Hollenberg
Mechanisms of cytochrome P450 and peroxidase-catalyzed xenobiotic metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):686-94.
1991: T L Shen; Z P Zhuang; Roy Barnard McCauley; David A Putt; Paul Hollenberg
Differential effects of proteinase K on the components of the liver microsomal cytochrome P-450 mixed function oxidase system.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(6):1016-21.
1989: L D Gorsky; Paul Hollenberg
Labeling of albumin secreted from isolated rat hepatocytes during the metabolism of N-nitrosodimethyl- and N-nitrosodiethylamine.
Chemical research in toxicology 1989;2(6):442-8.
1989: L D Gorsky; Paul Hollenberg
Metabolism of N-nitrosodimethyl- and N-nitrosodiethylamine by rat hepatocytes: effects of pretreatment with ethanol.
Chemical research in toxicology 1989;2(6):436-41.
1989: R N Pandey; A P Armstrong; Paul Hollenberg
Oxidative N-demethylation of N,N-dimethylaniline by purified isozymes of cytochrome P-450.
Biochemical pharmacology 1989;38(13):2181-5.
1989: FA Carone; Paul Hollenberg; S Nakamura; Phaibul Punyarit; W Glogowski; G Flouret
Tubular basement membrane change occurs pari passu with the development of cyst formation.
Kidney international 1989;35(4):1034-40.
1988: M M Mangino; Paul Hollenberg; DG Scarpelli
Uptake of N-nitrosobis(2-oxopropyl)amine by isolated rat and hamster hepatocytes: species differences and evidence for an active carrier-mediated transport process.
Carcinogenesis 1988;9(10):1763-72.
1987: M M Mangino; Paul Hollenberg; DG Scarpelli
Species specificity in the metabolism of N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine to mutagens by isolated rat and hamster hepatocytes.
Cancer research 1987;47(18):4776-81.
1987: R N Pandey; S C Kuemmerle; Paul Hollenberg
An investigation of the antigenic determinants on chloroperoxidase and purified rat liver microsomal cytochrome P-450b.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):518-23.
1987: D M Kokkinakis; DG Scarpelli; V Subbarao; Paul Hollenberg
Species differences in the metabolism of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.
Carcinogenesis 1987;8(2):295-303.
1987: D M Kokkinakis; R Wieboldt; Paul Hollenberg; DG Scarpelli
Structural relationships of pancreatic nitrosamine carcinogens.
Carcinogenesis 1987;8(1):81-90.
1986: Gregory L Kedderis; D E Rickert; R N Pandey; Paul Hollenberg
18O studies of the peroxidase-catalyzed oxidation of N-methylcarbazole. Mechanisms of carbinolamine and carboxaldehyde formation.
The Journal of biological chemistry 1986;261(34):15910-4.
1986: R N Pandey; L E Davis; B Anderson; Paul Hollenberg
Photochemical linking of primary aromatic amines to carrier proteins to elicit antibody response against the amine haptens.
Journal of immunological methods 1986;94(1-2):237-46.
1985: M M Mangino; DG Scarpelli; Paul Hollenberg
Activation of N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)-(2-oxopropyl)amine to mutagens for V79 cells by isolated hamster and rat pancreatic acinar cells.
Cancer research 1985;45(11 Pt 1):5219-24.
1985: G L Kedderis; Paul Hollenberg
Peroxidase-catalyzed N-demethylation reactions: deuterium solvent isotope effects.
Biochemistry 1985;24(22):6158-63.
1985: D M Kokkinakis; Paul Hollenberg; DG Scarpelli
Major urinary metabolites in hamsters and rats treated with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.
Cancer research 1985;45(8):3586-92.
1985: Paul Hollenberg; G T Miwa; J S Walsh; L A Dwyer; D E Rickert; Gregory L Kedderis
Mechanisms of N-demethylation reactions catalyzed by cytochrome P-450 and peroxidases.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(3):272-5.
1985: D M Kokkinakis; Dennis R Koop; DG Scarpelli; M J Coon; Paul Hollenberg
Metabolism of N-nitroso-2,6-dimethylmorpholine by isozymes of rabbit liver microsomal cytochrome P-450.
Cancer research 1985;45(2):619-24.
1984: D H Barch; S C Kuemmerle; Paul Hollenberg; P M Iannaccone
Esophageal microsomal metabolism of N-nitrosomethylbenzylamine in the zinc-deficient rat.
Cancer research 1984;44(12 Pt 1):5629-33.
1984: G L Kedderis; Paul Hollenberg
pH kinetic studies of the N-demethylation of N,N-dimethylaniline catalyzed by chloroperoxidase.
Archives of biochemistry and biophysics 1984;233(2):315-21.
1984: D Kokkinakis; Paul Hollenberg; D G Scarpelli
Metabolism of the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine and their deuterated analogs by liver microsomes of rat and hamster.
Carcinogenesis 1984;5(8):1009-14.
1984: G L Kedderis; Paul Hollenberg
Peroxidase-catalyzed N-demethylation reactions. Substrate deuterium isotope effects.
The Journal of biological chemistry 1984;259(6):3663-8.
1983: G T Miwa; J S Walsh; Gregory L Kedderis; Paul Hollenberg
The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.
The Journal of biological chemistry 1983;258(23):14445-9.
1983: D M Kokkinakis; DG Scarpelli; M S Rao; Paul Hollenberg
Metabolism of pancreatic carcinogens N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine by microsomes and cytosol of hamster pancreas and liver.
Cancer research 1983;43(12 Pt 1):5761-7.
1983: G L Kedderis; Paul Hollenberg
Steady state kinetics of chloroperoxidase-catalyzed N-demethylation reactions.
The Journal of biological chemistry 1983;258(20):12413-9.
1983: P M Iannaccone; L Stols; Paul Hollenberg; D P Gurka
An estradiol-responsive mouse endometrial cell strain with inducible aryl hydrocarbon hydroxylase activity.
Journal of cellular physiology 1983;116(2):227-35.
1983: G L Kedderis; Paul Hollenberg
Characterization of the N-demethylation reactions catalyzed by horseradish peroxidase.
The Journal of biological chemistry 1983;258(13):8129-38.
1983: Gregory L Kedderis; L A Dwyer; D E Rickert; Paul Hollenberg
Source of the oxygen atom in the product of cytochrome P-450-catalyzed N-demethylation reactions.
Molecular pharmacology 1983;23(3):758-60.
1982: DG Scarpelli; D M Kokkinakis; M S Rao; V Subbarao; N Luetteke; Paul Hollenberg
Metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine by hamster liver and component cells of pancreas.
Cancer research 1982;42(12):5089-95.
1981: M K Reddy; S A Qureshi; Paul Hollenberg; J K Reddy
Immunochemical identity of peroxisomal enoyl-CoA hydratase with the peroxisome-proliferation-associated 80,000 mol wt polypeptide in rat liver.
The Journal of cell biology 1981;89(3):406-17.
1980: G L Kedderis; Dennis R Koop; Paul Hollenberg
N-Demethylation reactions catalyzed by chloroperoxidase.
The Journal of biological chemistry 1980;255(21):10174-82.
1980: Dennis R Koop; Paul Hollenberg
Kinetics of the hydroperoxide-dependent dealkylation reactions catalyzed by rabbit liver microsomal cytochrome P-450.
The Journal of biological chemistry 1980;255(20):9685-92.
1980: M K Reddy; Paul Hollenberg; J K Reddy
Partial purification and immunoreactivity of an 80 000-molecular-weight polypeptide associated with peroxisome proliferation in rat liver.
The Biochemical journal 1980;188(3):731-40.
1980: Paul Hollenberg; Lowell P Hager; W E Blumberg; Jack Peisach
An electron paramagnetic resonance study of the high and low spin forms of chloroperoxidase.
The Journal of biological chemistry 1980;255(10):4801-7.
1980: Raymond F Novak; Dennis R Koop; Paul Hollenberg
Liver microsomal metabolism of N-methylcarbazole: structural identification of the four major metabolites of N-methylcarbazole using 1H Fourier transform NMR spectroscopy.
Molecular pharmacology 1980;17(1):128-36.
1980: Dennis R Koop; Paul Hollenberg
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Molecular pharmacology 1980;17(1):118-27.
1980: D G Scarpelli; M S Rao; V Subbarao; M Beversluis; D P Gurka; Paul Hollenberg
Activation of nitrosamines to mutagens by postmitochondrial fraction of hamster pancreas.
Cancer research 1980;40(1):67-74.
1977: M Y Wang; B M Hoffman; Paul Hollenberg
Cobalt-substituted horseradish peroxidase.
The Journal of biological chemistry 1977;252(18):6268-75.
1975: Lowell P Hager; Paul Hollenberg; T Rand-Meir; R Chiang; D Doubek
Chemistry of peroxidase intermediates.
Annals of the New York Academy of Sciences 1975;244():80-93.
1974: Paul Hollenberg; T Rand-Meir; Lowell P Hager
The reaction of chlorite with horseradish peroxidase and chloroperoxidase. Enzymatic chlorination and spectral intermediates.
The Journal of biological chemistry 1974;249(18):5816-25.
1973: Paul Hollenberg; Lowell P Hager
The P-450 nature of the carbon monoxide complex of ferrous chloroperoxidase.
The Journal of biological chemistry 1973;248(7):2630-3.
1973: Paul Champion; E Münck; P G Debrunner; Paul Hollenberg; Lowell P Hager
Mössbauer investigations of chloroperoxidase and its halide complexes.
Biochemistry 1973;12(3):426-35.
1972: M Flashner; Paul Hollenberg; M J Coon
Mechanism of action of pyruvate kinase. Role of sulfhydryl groups in catalytic activity as determined by disulfide interchange.
The Journal of biological chemistry 1972;247(24):8114-21.
1972: E W Czerwinski; F S Mathews; Paul Hollenberg; K Drickamer; Lowell P Hager
Crystallographic study of cytochrome b 562 from Escherichia coli.
Journal of molecular biology 1972;71(3):819-21.
1971: Paul Hollenberg; M Flashner; M J Coon
Role of lysyl epsilon-amino groups in adenosine diphosphate binding and catalytic activity of pyruvate kinase.
The Journal of biological chemistry 1971;246(4):946-53.
1969: G L Cottam; Paul Hollenberg; M J Coon
Subunit structure of rabbit muscle pyruvate kinase.
The Journal of biological chemistry 1969;244(6):1481-6.
1965: K P Wheeler; Y Inui; Paul Hollenberg; E Eavenson; H N Christensen
Relation of amino acid transport to sodium-ion concentration.
Biochimica et biophysica acta 1965;109(2):620-2.