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Richard Burchmore

Research Profile

Chemicals & Drugs

Disorders

Trypanosomiasis, African

Physiology

Drug Resistance

Procedures

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Publications

TOP 3
Xiuhong Feng; Stephen M Beverley; Richard J S Burchmore; Lon-Fye Lye; Tamsen Polley; Dayana D Rodriguez; David Scott; Scott M Landfear
'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.
Richard J S Burchmore
Parasites in the brain? The search for sleeping sickness biomarkers.
Hamid Daneshvar; Hossein Kamiabi; Mohammad M Molaei; Stephen Phillips; Farnaz Sedghy; Shahriar Dabiri; Richard J S Burchmore
Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum.

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All Publications

2013: Xiuhong Feng; Stephen M Beverley; Richard J S Burchmore; Lon-Fye Lye; Tamsen Polley; Dayana D Rodriguez; David Scott; Scott M Landfear
'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.
Molecular microbiology 2013;87(2):412-29.
2012: Richard J S Burchmore
Parasites in the brain? The search for sleeping sickness biomarkers.
Expert review of anti-infective therapy 2012;10(11):1283-6.
2012: Hamid Daneshvar; Hossein Kamiabi; Mohammad M Molaei; Stephen Phillips; Farnaz Sedghy; Shahriar Dabiri; Richard J S Burchmore
Alteration in mononuclear cell subpopulations in dogs immunized with gentamicin-attenuated Leishmania infantum.
Parasitology 2012;139(13):1689-96.
2012: Michael L Ginger; Richard J S Burchmore; Paul G McKean; Karen M Grant
Proteomic insights into parasite biology.
Parasitology 2012;139(9):1101-2.
2012: Karl Burgess; Richard J S Burchmore
Strategies to dissect parasite proteomes.
Parasitology 2012;139(9):1119-30.
2012: John Walker; Juan-José Vasquez; Richard J S Burchmore; Jolyne Drummelsmith; Maria Adelaida Gomez; Rafael Gongora; Marc Ouellette; Gaetan Roy; Nancy G Saravia
Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis.
Molecular and biochemical parasitology 2012;183(2):166-76.
2012: Laura E McNamara; Mathis O. Riehle; Chris D W Wilkinson; Pawel Herzyk; Manus J P Biggs; Richard J S Burchmore; Adam S G Curtis; Matthew J Dalby
The role of microtopography in cellular mechanotransduction.
Biomaterials 2012;33(10):2835-47.
2012: Hamid Daneshvar; Paul Hagan; Stephen Phillips; Susan Wyllie; Richard J S Burchmore
Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism.
Journal of proteomics 2012;75(5):1463-71.
2012: Isabel M Vincent; Debra J Woods; Richard J S Burchmore; Karl Burgess; Darren J Creek; Michael P Barrett
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
PLoS neglected tropical diseases 2012;6(5):e1618.
2012: Teerasak E-komon; Pawel Herzyk; Richard J S Burchmore; Robert Davies
Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation.
BMC bioinformatics 2012;13():63.
2011: Jonathan D A Hounsome; Neil W Isaacs; Mojtaba Noofeli; Alan Riboldi-Tunnicliffe; Susan Baillie; Richard J S Burchmore; Robert L Davies
Outer membrane protein A of bovine and ovine isolates of Mannheimia haemolytica is surface exposed and contains host species-specific epitopes.
Infection and immunity 2011;79(11):4332-41.
2011: Melissa Higón; Antonio Marcilla; Oreto Antúnez; Richard J S Burchmore; David Cavanagh; Graeme Cowan; Norman Nausch; Ana Oleaga; J Russell Stothard; Rafael Toledo; Francisca Mutapi
Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni.
Parasitology 2011;138(12):1607-19.
2011: Michael P Barrett; Richard J S Burchmore; Anne J N Kazibwe; Isabel M Vincent; Enock Matovu
Drug resistance in human African trypanosomiasis.
Future microbiology 2011;6(9):1037-47.
2011: Magda Gerou-Ferriani; Alix R McBrearty; Richard J S Burchmore; Kamburapola G I Jayawardena; Peter David Eckersall; Joanna S Morris
Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis.
Veterinary clinical pathology / American Society for Veterinary Clinical Pathology 2011;40(2):159-73.
2011: Francisca Mutapi; C Bourke; Yvonne M Harcus; Nicholas Midzi; Takafira MDULUZA; C Michael R Turner; Richard J S Burchmore; Rick M Maizels
Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4.
Parasite immunology 2011;33(3):181-92.
2010: Christopher P Ward; Karl E V Burgess; Richard J S Burchmore; Michael P Barrett; Harry P De Koning
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.
Molecular and biochemical parasitology 2010;174(2):145-9.
2010: H Daneshvar; M M Molaei; H Kamiabi; Richard J S Burchmore; Paul Hagan; R Stephen Phillips
Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis.
Parasite immunology 2010;32(11-12):722-30.
2010: Balázs Szöőr; Irene Ruberto; Richard J S Burchmore; Keith Matthews
A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.
Genes & development 2010;24(12):1306-16.
2010: Mhairi L Stewart; Richard J S Burchmore; Caroline Clucas; Christiane Hertz-Fowler; Karen Brooks; Andy Tait; Annette MacLeod; C Michael R Turner; Harry P De Koning; Pui Ee Wong; Michael P Barrett
Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.
Eukaryotic cell 2010;9(2):336-43.
2010: Isabel M Vincent; Darren Creek; David G Watson; Mohammed A Kamleh; Debra J Woods; Pui Ee Wong; Richard J S Burchmore; Michael P Barrett
A molecular mechanism for eflornithine resistance in African trypanosomes.
PLoS pathogens 2010;6(11):e1001204.
2009: Saeed Ataei; Richard J S Burchmore; J Christopher Hodgson; Anna Finucane; Roger Parton; John G Coote
Identification of immunogenic proteins associated with protection against haemorrhagic septicaemia after vaccination of calves with a live-attenuated aroA derivative of Pasteurella multocida B:2.
Research in veterinary science 2009;87(2):207-10.
2008: Francisca Mutapi; Richard J S Burchmore; Takafira MDULUZA; Nicholas Midzi; C Michael R Turner; Rick M Maizels
Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population.
The Journal of infectious diseases 2008;198(2):167-75.
2008: Christina Naula; Vincent P Alibu; Janice M Brock; Nicola J Veitch; Richard J S Burchmore; Michael P Barrett
A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.
Journal of biochemical and biophysical methods 2008;70(6):1185-7.
2008: Daniel J Bridges; Andrew Pitt; Orla Hanrahan; Kiva Brennan; H Paul Voorheis; Pawel Herzyk; Harry P De Koning; Richard J S Burchmore
Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei.
Proteomics 2008;8(1):83-99.
2007: Adele Hannigan; Richard J S Burchmore; Joanna Beatrice Wilson
The optimization of protocols for proteome difference gel electrophoresis (DiGE) analysis of preneoplastic skin.
Journal of proteome research 2007;6(9):3422-32.
2007: Daniel J Bridges; Matthew K Gould; Barbara Nerima; Pascal Mäser; Richard J S Burchmore; Harry P De Koning
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.
Molecular pharmacology 2007;71(4):1098-108.
2006: Van-Duc Luu; Stefanie Brems; Jörg D Hoheisel; Richard J S Burchmore; D Lys Guilbride; Christine Clayton
Functional analysis of Trypanosoma brucei PUF1.
Molecular and biochemical parasitology 2006;150(2):340-9.
2006: John Walker; Juan-José Vasquez; Maria Adelaida Gomez; Jolyne Drummelsmith; Richard J S Burchmore; Isabelle Girard; Marc Ouellette
Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes.
Molecular and biochemical parasitology 2006;147(1):64-73.
2006: Richard J S Burchmore
Identification of anti-infective targets through comparative proteomics.
Expert review of anti-infective therapy 2006;4(2):163-5.
2005: Harry P De Koning; Daniel J Bridges; Richard J S Burchmore
Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.
FEMS microbiology reviews 2005;29(5):987-1020.
2005: Francisca Mutapi; Richard J S Burchmore; Takafira MDULUZA; Aude Lise Foucher; Yvonne M Harcus; Gavin Nicoll; Nicholas Midzi; C Michael R Turner; Rick M Maizels
Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens.
The Journal of infectious diseases 2005;192(6):1108-18.
2005: Mhairi L Stewart; Sanjeev Krishna; Richard J S Burchmore; Reto Brun; Harry P De Koning; David W Boykin; Richard R Tidwell; J Ed Hall; Michael P Barrett
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
Lancet 2005;366(9484):486-7.
2004: Harry P De Koning; Laura F Anderson; Mhairi Stewart; Richard J S Burchmore; Lynsey J M Wallace; Michael P Barrett
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.
Antimicrobial agents and chemotherapy 2004;48(5):1515-9.
2003: Michael P Barrett; Richard J S Burchmore; August Stich; Julio O Lazzari; Alberto C C Frasch; Juan J Cazzulo; Sanjeev Krishna
The trypanosomiases.
Lancet 2003;362(9394):1469-80.
2003: Enock Matovu; Mhairi L Stewart; Federico Geiser; Reto Brun; Pascal Mäser; Lynsey J M Wallace; Richard J S Burchmore; John C K Enyaru; Michael P Barrett; Ronald Kaminsky; Thomas Seebeck; Harry P De Koning
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Eukaryotic cell 2003;2(5):1003-8.
2003: Dante Maugeri; Juan J Cazzulo; Richard J S Burchmore; Michael P Barrett; Patrick O J Ogbunude
Pentose phosphate metabolism in Leishmania mexicana.
Molecular and biochemical parasitology 2003;130(2):117-25.
2003: Richard J S Burchmore; Lynsey J M Wallace; Denise Candlish; Mohammed I Al-Salabi; Paul R Beal; Michael P Barrett; Stephen A Baldwin; Harry P De Koning
Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan.
The Journal of biological chemistry 2003;278(26):23502-7.
2003: Christina Naula; Richard J S Burchmore
A plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis.
Expert review of anti-infective therapy 2003;1(1):157-65.
2003: Richard J S Burchmore; Dayana D Rodriguez; Kathleen McBride; Patrick Merkel; Michael P Barrett; Govind Modi; David Sacks; Scott M Landfear
Genetic characterization of glucose transporter function in Leishmania mexicana.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3901-6.
2002: Graham Leslie; Michael Barrett; Richard J S Burchmore
Leishmania mexicana: promastigotes migrate through osmotic gradients.
Experimental parasitology 2002;102(2):117-20.
2002: Bertin Enanga; Richard J S Burchmore; Mhairi L Stewart; Michael P Barrett
Sleeping sickness and the brain.
Cellular and molecular life sciences : CMLS 2002;59(5):845-58.
2002: Richard J S Burchmore; Patrick O J Ogbunude; Bertin Enanga; Michael P Barrett
Chemotherapy of human African trypanosomiasis.
Current pharmaceutical design 2002;8(4):256-67.
2001: Richard J S Burchmore; Christoph S Janssen; C Michael R Turner
After the genome--where next?
Molecular and biochemical parasitology 2001;118(2):129-31.
2001: Richard J S Burchmore; Michael P Barrett
Life in vacuoles--nutrient acquisition by Leishmania amastigotes.
International journal for parasitology 2001;31(12):1311-20.
1998: Richard J S Burchmore; Scott M Landfear
Differential regulation of multiple glucose transporter genes in Leishmania mexicana.
The Journal of biological chemistry 1998;273(44):29118-26.