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Kenneth Smith

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T Hayton; K Hunter; David H Miller; Kenneth Smith; Daniel J Tozer; Daniel R Altmann; R Brenner; Jeremy Chataway; J Furby; Raju Kapoor
Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine.
T Hayton; K Hunter; David H Miller; Kenneth Smith; Daniel J Tozer; Daniel R Altmann; R Brenner; Jeremy Chataway; J Furby; Raju Kapoor
Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis.
J Furby; T Hayton; D Altmann; R Brenner; Jeremy Chataway; Kenneth Smith; David H Miller; Raju Kapoor
A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis.

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All Publications

2012: T Hayton; K Hunter; David H Miller; Kenneth Smith; Daniel J Tozer; Daniel R Altmann; R Brenner; Jeremy Chataway; J Furby; Raju Kapoor
Longitudinal changes in magnetisation transfer ratio in secondary progressive multiple sclerosis: data from a randomised placebo controlled trial of lamotrigine.
Journal of neurology 2012;259(3):505-14.
2012: T Hayton; K Hunter; David H Miller; Kenneth Smith; Daniel J Tozer; Daniel R Altmann; R Brenner; Jeremy Chataway; J Furby; Raju Kapoor
Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis.
Journal of neurology 2012;259(2):237-45.
2010: J Furby; T Hayton; D Altmann; R Brenner; Jeremy Chataway; Kenneth Smith; David H Miller; Raju Kapoor
A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis.
Journal of neurology 2010;257(9):1508-16.
2009: T Hayton; J Furby; Kenneth Smith; Daniel R Altmann; R Brenner; J Chataway; R A C Hughes; K Hunter; Daniel J Tozer; David H Miller; Raju Kapoor
Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis.
Journal of neurology 2009;256(3):427-35.
2007: Christina Marik; Paul A Felts; Jan Bauer; Hans Lassmann; Kenneth Smith
Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
Brain : a journal of neurology 2007;130(Pt 11):2800-15.
2007: Kenneth Smith
Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy.
Brain pathology (Zurich, Switzerland) 2007;17(2):230-42.
2006: David A Bechtold; Sandra J Miller; Angela C Dawson; Yue Sun; Raju Kapoor; David Berry; Kenneth Smith
Axonal protection achieved in a model of multiple sclerosis using lamotrigine.
Journal of neurology 2006;253(12):1542-51.
2006: Kenneth Smith
Axonal protection in multiple sclerosis--a particular need during remyelination?
Brain : a journal of neurology 2006;129(Pt 12):3147-9.
2006: Kenneth Smith
[Pathophysiology of multiple sclerosis].
La Revue du praticien 2006;56(12):1299-303.
2006: J Black; Stephen G Waxman; Kenneth Smith
Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier.
Brain : a journal of neurology 2006;129(Pt 5):1319-29.
2005: Paul A Felts; Anne-Marie Woolston; Himali B Fernando; Stephen Asquith; Norman A Gregson; Oliver J Mizzi; Kenneth Smith
Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide.
Brain : a journal of neurology 2005;128(Pt 7):1649-66.
2005: David A Bechtold; Kenneth Smith
Sodium-mediated axonal degeneration in inflammatory demyelinating disease.
Journal of the neurological sciences 2005;233(1-2):27-35.
2005: David A Bechtold; Xu Yue; Richard M Evans; Meirion Davies; Norman A Gregson; Kenneth Smith
Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide.
Brain : a journal of neurology 2005;128(Pt 1):18-28.
2004: David A Bechtold; Raju Kapoor; Kenneth Smith
Axonal protection using flecainide in experimental autoimmune encephalomyelitis.
Annals of neurology 2004;55(5):607-16.
2004: M Demestre; Graham M A Wells; Karen M Miller; Kenneth Smith; Richard AC Hughes; AJ Gearing; Norman A Gregson
Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration.
Neuroscience 2004;124(4):767-79.
2003: A Dilley; Norman A Gregson; R D M Hadden; Kenneth Smith
Effects on axonal conduction of anti-ganglioside sera and sera from patients with Guillain-Barré syndrome.
Journal of neuroimmunology 2003;139(1-2):133-40.
2003: Raju Kapoor; Meirion Davies; Paul A Blaker; Susan M Hall; Kenneth Smith
Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration.
Annals of neurology 2003;53(2):174-80.
2002: R D M Hadden; Norman A Gregson; R Gold; Kenneth Smith; Richard AC Hughes
Accumulation of immunoglobulin across the 'blood-nerve barrier' in spinal roots in adoptive transfer experimental autoimmune neuritis.
Neuropathology and applied neurobiology 2002;28(6):489-97.
2002: Kenneth Smith; Hans Lassmann
The role of nitric oxide in multiple sclerosis.
Lancet neurology 2002;1(4):232-41.
2002: Paul A Felts; Kenneth Smith; Norman A Gregson; Richard AC Hughes
Brain-derived neurotrophic factor in experimental autoimmune neuritis.
Journal of neuroimmunology 2002;124(1-2):62-9.
2001: Peter Rieckmann; Kenneth Smith
Multiple sclerosis: more than inflammation and demyelination.
Trends in neurosciences 2001;24(8):435-7.
2001: Kenneth Smith; S M Hall
Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding.
Current opinion in neurology 2001;14(3):289-98.
2001: Kenneth Smith; R Kapoor; S M Hall; M Davies
Electrically active axons degenerate when exposed to nitric oxide.
Annals of neurology 2001;49(4):470-6.
2000: S M Hall; E J Redford; Kenneth Smith
Tumour necrosis factor-alpha has few morphological effects within the dorsal columns of the spinal cord, in contrast to its effects in the peripheral nervous system.
Journal of neuroimmunology 2000;106(1-2):130-6.
2000: Kenneth Smith; P A Felts; G R John
Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension.
Brain : a journal of neurology 2000;123 ( Pt 1)():171-84.
1999: Richard AC Hughes; R D M Hadden; Norman A Gregson; Kenneth Smith
Pathogenesis of Guillain-Barré syndrome.
Journal of neuroimmunology 1999;100(1-2):74-97.
1999: Kenneth Smith; W I McDonald
The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1390):1649-73.
1999: M Demestre; Norman A Gregson; Kenneth Smith; Karen M Miller; AJ Gearing; Richard AC Hughes
Effect of a matrix metalloproteinase inhibitor (BB-1101) on nerve regeneration.
Annals of the New York Academy of Sciences 1999;878():658-61.
1999: R Kapoor; M Davies; Kenneth Smith
Temporary axonal conduction block and axonal loss in inflammatory neurological disease. A potential role for nitric oxide?
Annals of the New York Academy of Sciences 1999;893():304-8.
1999: Kenneth Smith; R Kapoor; P A Felts
Demyelination: the role of reactive oxygen and nitrogen species.
Brain pathology (Zurich, Switzerland) 1999;9(1):69-92.
1998: CM Gabriel; Richard AC Hughes; S E Moore; Kenneth Smith; Frank S Walsh
Induction of experimental autoimmune neuritis with peripheral myelin protein-22.
Brain : a journal of neurology 1998;121 ( Pt 10)():1895-902.
1998: Paula M Hughes; Graham M A Wells; John M Clements; AJ Gearing; EJ Redford; M Davies; Kenneth Smith; Richard AC Hughes; M C Brown; Karen M Miller
Matrix metalloproteinase expression during experimental autoimmune neuritis.
Brain : a journal of neurology 1998;121 ( Pt 3)():481-94.
1997: E J Redford; R Kapoor; Kenneth Smith
Nitric oxide donors reversibly block axonal conduction: demyelinated axons are especially susceptible.
Brain : a journal of neurology 1997;120 ( Pt 12)():2149-57.
1997: EJ Redford; Kenneth Smith; Norman A Gregson; M Davies; P Hughes; AJ Gearing; K Miller; Richard AC Hughes
A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis.
Brain : a journal of neurology 1997;120 ( Pt 10)():1895-905.
1997: P A Felts; T A Baker; Kenneth Smith
Conduction in segmentally demyelinated mammalian central axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(19):7267-77.
1997: CM Gabriel; Norman A Gregson; EJ Redford; M Davies; Kenneth Smith; Richard AC Hughes
Human immunoglobulin ameliorates rat experimental autoimmune neuritis.
Brain : a journal of neurology 1997;120 ( Pt 9)():1533-40.
1997: J Black; PA Felts; Kenneth Smith; J D Kocsis; Stephen G Waxman
Distribution of sodium channels in chronically demyelinated spinal cord axons: immunoultrastructural localization and electrophysiological observations. Brain Research 544 (1991) 59-70.
Brain research 1997;761(1):1.
1997: Richard AC Hughes; CM Gabriel; Norman A Gregson; Kenneth Smith
Treatment of inflammatory neuropathy.
Multiple sclerosis (Houndmills, Basingstoke, England) 1997;3(2):88-92.
1997: R Kapoor; Y G Li; Kenneth Smith
Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.
Brain : a journal of neurology 1997;120 ( Pt 4)():647-52.
1997: CV Meléndez-Vásquez; J Redford; P P Choudhary; IA Gray; P Maitland; Norman A Gregson; Kenneth Smith; Richard AC Hughes
Immunological investigation of chronic inflammatory demyelinating polyradiculoneuropathy.
Journal of neuroimmunology 1997;73(1-2):124-34.
1996: P A Felts; Kenneth Smith
Blood-brain barrier permeability in astrocyte-free regions of the central nervous system remyelinated by Schwann cells.
Neuroscience 1996;75(2):643-55.
1996: P A Felts; Kenneth Smith
Changes in the distribution of a calcium-dependent ATPase during demyelination and remyelination in the central nervous system.
Journal of neurocytology 1996;25(3):171-80.
1995: P A Felts; R Kapoor; Kenneth Smith
A mechanism for ectopic firing in central demyelinated axons.
Brain : a journal of neurology 1995;118 ( Pt 5)():1225-31.
1995: E J Redford; S M Hall; Kenneth Smith
Vascular changes and demyelination induced by the intraneural injection of tumour necrosis factor.
Brain : a journal of neurology 1995;118 ( Pt 4)():869-78.
1994: Kenneth Smith; S M Hall
Central demyelination induced in vivo by the calcium ionophore ionomycin.
Brain : a journal of neurology 1994;117 ( Pt 6)():1351-6.
1994: P A Felts; Kenneth Smith
The use of potassium channel blocking agents in the therapy of demyelinating diseases.
Annals of neurology 1994;36(3):454.
1994: Kenneth Smith
Conduction properties of central demyelinated and remyelinated axons, and their relation to symptom production in demyelinating disorders.
Eye (London, England) 1994;8 ( Pt 2)():224-37.
1993: R Kapoor; Kenneth Smith; P A Felts; M Davies
Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons.
Brain research 1993;611(1):165-9.
1992: Kenneth Smith; R T Kodama; FJ Liuzzi
Is CNS trauma a prerequisite for the elongation of CNS axons into denervated peripheral nerve?
Brain research 1992;575(1):79-85.
1992: P A Felts; Kenneth Smith
Conduction properties of central nerve fibers remyelinated by Schwann cells.
Brain research 1992;574(1-2):178-92.
1991: Kenneth Smith; R T Kodama
Reinnervation of denervated skeletal muscle by central neurons regenerating via ventral roots implanted into the spinal cord.
Brain research 1991;551(1-2):221-9.
1991: J Black; P Felts; Kenneth Smith; Jeffery D Kocsis; Stephen G Waxman
Distribution of sodium channels in chronically demyelinated spinal cord axons: immuno-ultrastructural localization and electrophysiological observations.
Brain research 1991;544(1):59-70.
1991: P A Felts; Kenneth Smith; E Tilt
Blood-brain barrier function in central demyelinating lesions repaired by Schwann cell remyelination.
Annals of the New York Academy of Sciences 1991;633():615-6.
1989: Kenneth Smith; P A Felts
End-tidal carbon dioxide (CO2) monitoring in small animals.
Brain research bulletin 1989;22(3):579-82.
1988: Kenneth Smith; P C Larramendi
A simple device to aid tissue processing of large numbers of blocks for light or electron microscopy.
Journal of electron microscopy technique 1988;8(2):223-4.
1988: Kenneth Smith; Julia Terzis; M Erasmus; K A Carson
Reinnervation of denervated skeletal muscle by central nerve fibers regenerating along replanted ventral roots.
Progress in brain research 1988;78():193-8.
1987: Kenneth Smith; B J Bennett
Topographic and quantitative description of rat dorsal column fibres arising from the lumbar dorsal roots.
Journal of anatomy 1987;153():203-15.
1987: Julia Terzis; Kenneth Smith
Repair of severed peripheral nerves: comparison of the "de Medinaceli" and standard microsuture methods.
Experimental neurology 1987;96(3):672-80.
1983: W F Blakemore; Kenneth Smith
Node-like axonal specializations along demyelinated central nerve fibres: ultrastructural observations.
Acta neuropathologica 1983;60(3-4):291-6.
1982: Kenneth Smith; W F Blakemore; J A Murray; R C Patterson
Internodal myelin volume and axon surface area. A relationship determining myelin thickness?
Journal of the neurological sciences 1982;55(2):231-46.
1982: Kenneth Smith; W I McDonald
Spontaneous and evoked electrical discharges from a central demyelinating lesion.
Journal of the neurological sciences 1982;55(1):39-47.
1982: Kenneth Smith; H Bostock; S M Hall
Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline.
Journal of the neurological sciences 1982;54(1):13-31.
1982: C L Schauf; Kenneth Smith
Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.
The Journal of physiology 1982;323():157-71.
1981: Kenneth Smith; C L Schauf
Size-dependent variation of nodal properties in myelinated nerve.
Nature 1981;293(5830):297-9.
1981: Kenneth Smith; C L Schauf
Gallamine triethiodide (flaxedil): tetraethylammonium- and pancuronium-like effects in myelinated nerve fibers.
Science (New York, N.Y.) 1981;212(4499):1170-2.
1981: Kenneth Smith; C L Schauf
Effects of gallamine triethiodide on membrane currents in amphibian and mammalian peripheral nerve.
The Journal of pharmacology and experimental therapeutics 1981;217(3):719-26.
1981: Kenneth Smith; W F Blakemore; W I McDonald
The restoration of conduction by central remyelination.
Brain : a journal of neurology 1981;104(2):383-404.
1980: Kenneth Smith; S M Hall
Nerve conduction during peripheral demyelination and remyelination.
Journal of the neurological sciences 1980;48(2):201-19.
1980: Kenneth Smith
A sensitive method for the detection and quantification of conduction deficits in nerve.
Journal of the neurological sciences 1980;48(2):191-9.
1980: Kenneth Smith; W I McDonald
Spontaneous and mechanically evoked activity due to central demyelinating lesion.
Nature 1980;286(5769):154-5.
1979: Kenneth Smith; W I McDonald; W F Blakemore
Restoration of secure conduction by central demyelination.
Transactions of the American Neurological Association 1979;104():25-9.
1978: Kenneth Smith
A method to represent the spectrum of refractory periods of transmission of the constituent fibres of a nerve [proceedings].
The Journal of physiology 1978;276():7P-9P.
1977: W F Blakemore; R A Eames; Kenneth Smith; W I McDonald
Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin.
Journal of the neurological sciences 1977;33(1-2):31-43.