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Flemming Pociot

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Thilde Nordmann Winther; Flemming Pociot; Claus Heiner Bang-Berthelsen; Ida Louise Heiberg; Birthe Hogh
Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B.
Anne Julie Overgaard; Hans-Henrik Parving; Peter Hovind; James N McGuire; Peter Rossing; Flemming Pociot
Serum amyloid A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients.
Jannet Svensson; Åke Lernmark; Bendix Carstensen; Stefanie Eising; David Michael Hougaard; Jesper Johannesen; Henrik Bindesbøl Mortensen; Anita Nilsson; Flemming Pociot; Lars Bjarke Simonsen; Kristin Skogstrand
Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings.

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2013: Thilde Nordmann Winther; Flemming Pociot; Claus Heiner Bang-Berthelsen; Ida Louise Heiberg; Birthe Hogh
Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B.
PloS one 2013;8(3):e58236.
2013: Anne Julie Overgaard; Hans-Henrik Parving; Peter Hovind; James N McGuire; Peter Rossing; Flemming Pociot
Serum amyloid A and C-reactive protein levels may predict microalbuminuria and macroalbuminuria in newly diagnosed type 1 diabetic patients.
Journal of diabetes and its complications 2013;27(1):59-63.
2012: Jannet Svensson; Åke Lernmark; Bendix Carstensen; Stefanie Eising; David Michael Hougaard; Jesper Johannesen; Henrik Bindesbøl Mortensen; Anita Nilsson; Flemming Pociot; Lars Bjarke Simonsen; Kristin Skogstrand
Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings.
Human immunology 2012;73(11):1116-26.
2012: Joanna M M Howson; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Flemming Pociot; Marian Rewers; Stephen S Rich; Jin-Xiong She; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Beena Akolkar; Patrick Concannon; Jason D Cooper; George S Eisenbarth; Henry A Erlich
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes.
Diabetes 2012;61(11):3012-7.
2012: Kasper Engholm-Keller; Thomas Mandrup-Poulsen; Flemming Pociot; Joachim Størling; Pernille Birck; Martin R Larsen
TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC.
Journal of proteomics 2012;75(18):5749-61.
2012: Jakob Bondo Hansen; R Scott Heller; Birgitte Holst; Allan E Karlsen; Andreas Nygaard Madsen; Anja Østergren Nielsen; Flemming Pociot; Klaus Qvortrup; Joachim Størling; Morten Fog Tonnesen; Mogens Aalund; Nancy C Andrews; Leeat Anker-Kitai; Luc Baeyens; Nils Billestrup; Luc Bouwens; Shimon Efrat; Josefine Friberg; Lars Groth Grunnet; Peter H Hagedorn; Thomas Mandrup-Poulsen
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Cell metabolism 2012;16(4):449-61.
2012: Giuseppe Palmisano; Flemming Pociot; Søren Skov Jensen; Jeanne Lainé; Marie-Catherine Le Bihan; James N McGuire; Martin R Larsen
Characterization of membrane-shed microvesicles from cytokine-stimulated β-cells using proteomics strategies.
Molecular & cellular proteomics : MCP 2012;11(8):230-43.
2012: J S Sorensen; Fariba Vaziri-Sani; N H Birkebaek; N Breslow; C Brorsson; A Ellerman; K Kristensen; Ake Lernmark; M Maziarz; Flemming Pociot
Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years.
Diabetes research and clinical practice 2012;96(2):204-10.
2012: Regine Bergholdt; Caroline Brorsson; Tina Fløyel; Klaus Stensgaard Frederiksen; Lars Juhl Jensen; Albert Palleja; Claus Heiner Bang-Berthelsen; Lukas A Berchtold; Joachim Størling; Flemming Pociot
Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression.
Diabetes 2012;61(4):954-62.
2012: Lotte B Nielsen; Flemming Pociot; Kaspar Sørensen; Cheng Wang; Chen-Yu Zhang; Marie-Louise M Andersen; Claus H Bang-Berthelsen; Lars Hansen; Philip Hougaard; Anders Juul; Henrik B Mortensen
Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression.
Experimental diabetes research 2012;2012():896362.
2012: Samina Asad; Hedvig Bennet; Annelie Carlsson; Malin Fex; Gun Forsander; Alexandra Gyllenberg; Ola Hansson; Sten-Anders Ivarsson; Helena Larsson; Bengt Lindblad; Johnny Ludvigsson; Holger Luthman; Claude Marcus; Jan Nerup; Pernilla Nikamo; Flemming Pociot; Kjersti S Rønningen; Nils Wierup; Ake Lernmark; Ingrid Kockum
HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.
PloS one 2012;7(5):e35439.
2011: Lotte B Nielsen; Flemming Pociot; Sven Pörksen; Jannet Svensson; Fariba Vaziri-Sani; Marie-Louise M Andersen; Regine Bergholdt; Luis Castaño; Carine de Beaufort; Lars Hansen; Philip Hougaard; Ake Lernmark; Henrik B Mortensen
Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes.
Autoimmunity 2011;44(8):616-23.
2011: Lukas Adrian Berchtold; Regine Bergholdt; Caroline Anna Brorsson; Søren Brunak; Decio Laks Eizirik; Jacob Hald; Kasper Lage; Fernanda Ortis; Flemming Pociot; Claus Bang-Berthelsen; Zenia Marian Størling; Joachim Størling
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):E681-8.
2011: Grant Morahan; Munish Mehta; Ian James; Wei-Min Chen; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.
Diabetes 2011;60(3):1030-40.
2011: Caroline Brorsson; Fariba Vaziri-Sani; Regine Bergholdt; Stefanie Eising; Anita Nilsson; Jannet Svensson; Åke Lernmark; Flemming Pociot
Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes.
Autoimmunity 2011;44(2):107-14.
2011: Jesper Johannesen; Jannet Svensson; Regine Bergholdt; Stefanie Eising; Hanne Gramstrup; Erik Frandsen; Jens Dick-Nielsen; Lars Hansen; Flemming Pociot; Henrik B Mortensen
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes.
Pediatric diabetes 2011;12(2):100-6.
2011: Stefanie Eising; Anita Nilsson; Bendix Carstensen; David M Hougaard; Bent Nørgaard-Pedersen; Jørn Nerup; Ake Lernmark; Flemming Pociot
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(2):247-52.
2011: Jacob P Thyssen; Berit C Carlsen; Kåre Engkilde; Torben Hansen; Jeanne D Johansen; Allan Linneberg; Michael Meldgaard; Oluf Pedersen; Flemming Pociot; Steen Stender; Pal B Szecsi; Torkil Menné
A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study.
BMJ open 2011;1(1):e000062.
2011: Caroline Brorsson; Flemming Pociot
Genetics of diabetic nephropathy in diverse ethnic groups.
Contributions to nephrology 2011;170():8-18.
2011: Claus H Bang-Berthelsen; Lykke Pedersen; Tina Fløyel; Peter H Hagedorn; T Gylvin; Flemming Pociot
Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes.
BMC genomics 2011;12():97.
2010: James N McGuire; Stephanie Eising; Ana M Wägner; Flemming Pociot
Screening newborns for candidate biomarkers of type 1 diabetes.
Archives of physiology and biochemistry 2010;116(4-5):227-32.
2010: Henning G Hansen; Julie Overgaard; Maria Lajer; Frantisek Hubalek; Peter Højrup; Lykke Pedersen; Lise Tarnow; Peter Rossing; Flemming Pociot; James N McGuire
Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis.
Proteomics. Clinical applications 2010;4(8-9):697-705.
2010: Flemming Pociot; Beena Akolkar; Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Concepcion R Nierras; John A Todd; Stephen S Rich; Jørn Nerup
Genetics of type 1 diabetes: what's next?
Diabetes 2010;59(7):1561-71.
2010: Josefine Friberg; Morten F Tonnesen; Schott Heller; Flemming Pociot; Thóra B Bödvarsdottir; Allan E Karlsen
Inhibition of the nuclear factor-κB pathway prevents beta cell failure and diet induced diabetes in Psammomys obesus.
PloS one 2010;5(10):e13341.
2010: Trine W Boesgaard; Stepanka Pruhova; Ehm A Andersson; Ondrej Cinek; Barbora Obermannova; Jeannet Lauenborg; Peter Damm; Regine Bergholdt; Flemming Pociot; Charlotta Pisinger; Fabrizio Barbetti; Jan Lebl; Oluf Pedersen; Torben Hansen
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
BMC medical genetics 2010;11():42.
2010: Caroline Brorsson; Niclas Tue Hansen; Regine Bergholdt; Søren Brunak; Flemming Pociot
The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes.
PloS one 2010;5(3):e9576.
2010: Anne Julie Overgaard; Henning Gram Hansen; Maria Lajer; Lykke Pedersen; Lise Tarnow; Peter Rossing; James N McGuire; Flemming Pociot
Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy.
Proteome science 2010;8():4.
2009: Regine Bergholdt; C Brorsson; B Boehm; Grant Morahan; Flemming Pociot
No association of the IRS1 and PAX4 genes with type I diabetes.
Genes and immunity 2009;10 Suppl 1():S49-53.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Current status and the future for the genetics of type I diabetes.
Genes and immunity 2009;10 Suppl 1():S128-31.
2009: S S Rich; B Akolkar; Patrick Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Overview of the Type I Diabetes Genetics Consortium.
Genes and immunity 2009;10 Suppl 1():S1-4.
2009: Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature genetics 2009;41(6):703-7.
2009: Patrick Concannon; Wei-Min Chen; Cécile Julier; Grant Morahan; Beena Akolkar; Henry A Erlich; Joan E Hilner; Jørn Nerup; Concepcion Nierras; Flemming Pociot; John A Todd; Stephen S Rich
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
Diabetes 2009;58(4):1018-22.
2009: T Gylvin; Jakob Ek; Runa Louise Nolsoe; Anders Albrechtsen; Gitte Andersen; Regine Bergholdt; C Brorsson; C H Bang-Berthelsen; Torben Hansen; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2009: S S Rich; B Akolkar; P Concannon; Henry A Erlich; Joan E Hilner; C Julier; Grant Morahan; Jørn Nerup; C Nierras; Flemming Pociot; John A Todd
Results of the MHC fine mapping workshop.
Diabetes, obesity & metabolism 2009;11 Suppl 1():108-9.
2009: C Brorsson; N T Hansen; K Lage; Regine Bergholdt; Søren Brunak; Flemming Pociot
Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data.
Diabetes, obesity & metabolism 2009;11 Suppl 1():60-6.
2009: Regine Bergholdt; Caroline Brorsson; Kasper Lage; Jens Høiriis Nielsen; Søren Brunak; Flemming Pociot
Expression profiling of human genetic and protein interaction networks in type 1 diabetes.
PloS one 2009;4(7):e6250.
2009: Laerke Egefjord; Jens Ledet Jensen; Claus Heiner Bang-Berthelsen; Andreas Brønden Petersen; Kamille Smidt; Ole Schmitz; Allan Ertman Karlsen; Flemming Pociot; Fabrice Chimienti; Jørgen Rungby; Nils E Magnusson
Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?
BMC endocrine disorders 2009;9():7.
2008: Patrick Concannon; Suna Onengut-Gumuscu; John A Todd; Deborah J Smyth; Flemming Pociot; Regine Bergholdt; Beena Akolkar; Henry A Erlich; Joan E Hilner; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion R Nierras; Wei-Min Chen; Stephen S Rich
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Diabetes 2008;57(10):2858-61.
2008: Sven Pörksen; Lotte B Nielsen; Henrik B Mortensen; Thomas Danne; Mirjana Kocova; Luis Castaño; Flemming Pociot; Philip Hougaard; Claus T Ekstrøm; Steen Gammeltoft; Mikael Knip; Lars Hansen
Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes.
Pediatric diabetes 2008;9(4 Pt 1):297-302.
2008: Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sørensen; David M Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot
A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
Molecular genetics and metabolism 2008;94(3):386-8.
2008: Ana M Wägner; Paul Cloos; Regine Bergholdt; Stefanie Eising; Caroline Brorsson; Martin Stahlhut; Stephan Christgau; Jørn Nerup; Flemming Pociot
Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.
The review of diabetic studies : RDS 2008;5(4):225-31.
2008: James N McGuire; Julie Overgaard; Flemming Pociot
Mass spectrometry is only one piece of the puzzle in clinical proteomics.
Briefings in functional genomics & proteomics 2008;7(1):74-83.
2007: Stefanie Eising; Jannet Svensson; Kristin Skogstrand; Anita Nilsson; Kristian Lynch; Paal Skytt Andersen; Ake Lernmark; David M Hougaard; Flemming Pociot; Bent Nørgaard-Pedersen; Jørn Nerup
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
Paediatric and perinatal epidemiology 2007;21(6):507-17.
2007: G Thomson; A M Valdes; J A Noble; I Kockum; M N Grote; J Najman; Henry A Erlich; F Cucca; Alberto Pugliese; A Steenkiste; J S Dorman; S Caillat-Zucman; R Hermann; J Ilonen; A P Lambert; P J Bingley; K M Gillespie; A Lernmark; C B Sanjeevi; K S Rønningen; DAG UNDLIEN; E Thorsby; A Petrone; R Buzzetti; B P C Koeleman; B O Roep; G Saruhan-Direskeneli; F A Uyar; H Günoz; C Gorodezky; C Alaez; B O Boehm; W Mlynarski; H Ikegami; M Berrino; M E Fasano; E Dametto; S Israel; C Brautbar; A Santiago-Cortes; T Frazer de Llado; Jin-Xiong She; T L Bugawan; J I Rotter; L Raffel; A Zeidler; Francisco Leyva-Cobian; B R Hawkins; S H Chan; L Castano; Flemming Pociot; J Nerup
Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.
Tissue antigens 2007;70(2):110-27.
2007: Benedicte Lie; Marte K Viken; Hanne E Akselsen; Siri T Flåm; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Anne Cambon-Thomsen; Erik Thorsby; DAG UNDLIEN
Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.
Human immunology 2007;68(7):592-8.
2007: Regine Bergholdt; Allan E Karlsen; P H Hagedorn; M Aalund; Jens H Nielsen; Mogens Kruhøffer; T Orntoft; H Wang; C B Wollheim; Jørn Nerup; Flemming Pociot
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.
Genes and immunity 2007;8(3):232-8.
2007: Kasper Lage; E Olof Karlberg; Zenia M Størling; Páll I Olason; Anders G Pedersen; Olga Rigina; Anders M Hinsby; Zeynep Tümer; Flemming Pociot; Niels Tommerup; Yves Moreau; Søren Brunak
A human phenome-interactome network of protein complexes implicated in genetic disorders.
Nature biotechnology 2007;25(3):309-16.
2007: A M Wägner; Paul Cloos; Regine Bergholdt; Patrice Boissy; Thomas L Andersen; Dennis B Henriksen; C Christiansen; Stephan Christgau; Flemming Pociot; Jørn Nerup
Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
Diabetologia 2007;50(3):676-81.
2007: Claude Chelala; Sabine Duchatelet; Marie-Line Joffret; Regine Bergholdt; Danièle Dubois-Laforgue; Pegah Ghandil; Flemming Pociot; Sophie Caillat-Zucman; José Timsit; Cécile Julier
PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.
Diabetes 2007;56(2):522-6.
2007: Regine Bergholdt; Zenia M Størling; Kasper Lage; E Olof Karlberg; Páll I Olason; Mogens Aalund; Jørn Nerup; Søren Brunak; Christopher T Workman; Flemming Pociot
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.
Genome biology 2007;8(11):R253.
2006: K V Skovhus; Regine Bergholdt; C Erichsen; Thomas Sparre; Jørn Nerup; Allan E Karlsen; Flemming Pociot
Identification and characterization of secretagogin promoter activity.
Scandinavian journal of immunology 2006;64(6):639-45.
2006: Stephen S Rich; Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Jorn Nerup; Flemming Pociot; John A Todd
The Type 1 Diabetes Genetics Consortium.
Annals of the New York Academy of Sciences 2006;1079():1-8.
2006: Ulla Bjerre Christensen; Peter Mose Larsen; Stephen Fey; Allan E Karlsen; Flemming Pociot; Jørn Nerup; Thomas Sparre
Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats.
Autoimmunity 2006;39(4):315-21.
2006: Runa Louise Nolsoe; Yasmin H Hamid; Flemming Pociot; S Paulsen; K M Andersen; Knut Borch-Johnsen; Thomas Drivsholm; Torben Hansen; Oluf Pedersen; Thomas Mandrup-Poulsen
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Genes and immunity 2006;7(4):316-21.
2006: Regine Bergholdt; Stefanie Eising; Jørn Nerup; Flemming Pociot
Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.
Diabetologia 2006;49(6):1179-82.
2006: Allan E Karlsen; Zenia M Størling; Thomas Sparre; Martin R Larsen; Amer Mahmood; Joachim Størling; Peter Roepstorff; Krzysztof Wrzesinski; Peter Mose Larsen; Stephen Fey; Karin Nielsen; Peter E Heding; Camillo Ricordi; Jesper Johannesen; Ole P Kristiansen; Ulla Bjerre Christensen; Ingrid Kockum; Holger Luthman; Jørn Nerup; Flemming Pociot
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Biochemical and biophysical research communications 2006;344(1):406-15.
2006: Flemming Pociot
The relevance of international consortia in studies on the pathogenesis of type 1 diabetes: the role of ET1DGN.
Diabetes/metabolism research and reviews 2006;22(3):238-40.
2006: Anne Blomhoff; M Olsson; S Johansson; Hanne E Akselsen; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Anne Cambon-Thomsen; Erik Thorsby; DAG UNDLIEN; Benedicte Lie
Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.
Genes and immunity 2006;7(2):130-40.
2006: Anders Johansen; Dorit P Jensen; Regine Bergholdt; H B Mortensen; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Diabetes, obesity & metabolism 2006;8(1):75-82.
2006: Lotte B Nielsen; Henrik B Mortensen; Francesco Chiarelli; Reinhard W Holl; P G F Swift; Carine de Beaufort; Flemming Pociot; Philip Hougaard; Steen Gammeltoft; Mikael Knip; Lars Hansen
Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.
Diabetologia 2006;49(1):71-4.
2005: Runa Louise Nolsoe; J A Kelly; Flemming Pociot; K L Moser; Ole P Kristiansen; Thomas Mandrup-Poulsen; J B Harley
Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.
Genes and immunity 2005;6(8):699-706.
2005: Pegah Ghandil; Claude Chelala; Danièle Dubois-Laforgue; Valérie Senée; Sophie Caillat-Zucman; Ingrid Kockum; Holgar Luthman; Jorn Nerup; Flemming Pociot; José Timsit; Cécile Julier
Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes.
Molecular genetics and metabolism 2005;86(3):379-83.
2005: Patrick Concannon; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Flemming Pociot; John A Todd; Stephen S Rich
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.
Diabetes 2005;54(10):2995-3001.
2005: T Gylvin; Regine Bergholdt; Jørn Nerup; Flemming Pociot
To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905.
Diabetologia 2005;48(10):2183-4.
2005: Thomas Sparre; A M Ejrnaes Sprinkel; U Bjerre Christensen; Allan E Karlsen; Flemming Pociot; Jørn Nerup
Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats.
Acta diabetologica 2005;42(2):95-8.
2005: L Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B Nielsen; Henning Beck-Nielsen
OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.
Diabetes 2005;54(5):1588-91.
2005: Vagn Bonnevie-Nielsen; L Leigh Field; Shao Lu; Dong-Jun Zheng; Min Li; Pia M Martensen; Thomas B Nielsen; Henning Beck-Nielsen; Yu-Lung Lau; Flemming Pociot
Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.
American journal of human genetics 2005;76(4):623-33.
2005: Thomas Sparre; Martin R Larsen; Peter E Heding; Allan E Karlsen; Ole N Jensen; Flemming Pociot
Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions.
Molecular & cellular proteomics : MCP 2005;4(4):441-57.
2005: Regine Bergholdt; Camilla Taxvig; Stefanie Eising; Jørn Nerup; Flemming Pociot
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
Journal of leukocyte biology 2005;77(4):579-85.
2005: Regine Bergholdt; Jørn Nerup; Flemming Pociot
Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes.
Journal of medical genetics 2005;42(1):17-25.
2004: Allan E Karlsen; Peter E Heding; H Frobøse; Sif G Rønn; Mogens Kruhøffer; T F Orntoft; Martine I Darville; Decio L Eizirik; Flemming Pociot; Jørn Nerup; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: Jesper Johannesen; Angeles Pie; Allan E Karlsen; Zenia Marian Larsen; Allan Jensen; Henrik Vissing; Ole P Kristiansen; Flemming Pociot; Jørn Nerup
Is mortalin a candidate gene for T1DM ?
Autoimmunity 2004;37(6-7):423-30.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Ole P Kristiansen; Allan E Karlsen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.
Scandinavian journal of immunology 2004;59(6):582-91.
2004: Thomas Sparre; Ulla Bjerre Christensen; C F Gotfredsen; Peter Mose Larsen; Stephen Fey; K Hjernø; Peter Roepstorff; Flemming Pociot; Allan E Karlsen; Jørn Nerup
Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.
Diabetologia 2004;47(5):892-908.
2004: Regine Bergholdt; Pegah Ghandil; Jesper Johannesen; Ole P Kristiansen; Ingrid Kockum; H Luthman; Kjersti S Rønningen; Jørn Nerup; Cécile Julier; Flemming Pociot
Genetic and functional evaluation of an interleukin-12 polymorphism (IDDM18) in families with type 1 diabetes.
Journal of medical genetics 2004;41(4):e39.
2004: Flemming Pociot; Allan E Karlsen; Claus B Pedersen; Mogens Aalund; Jørn Nerup
Novel analytical methods applied to type 1 diabetes genome-scan data.
American journal of human genetics 2004;74(4):647-60.
2004: Zenia Marian Larsen; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup; Flemming Pociot
Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(3):218-22.
2004: Regine Bergholdt; Peter E Heding; Karin Nielsen; Runa Louise Nolsoe; Thomas Sparre; Joachim Størling; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
Type 1 database mellitus: an inflammatory disease of the islet.
Advances in experimental medicine and biology 2004;552():129-53.
2003: Runa Louise Nolsoe; Flemming Pociot; Daniela Novick; Menachem Rubinstein; Soo-Hyun Kim; Charles A Dinarello; Thomas Mandrup-Poulsen
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene.
Annals of the New York Academy of Sciences 2003;1005():332-9.
2003: Thomas Sparre; Regine Bergholdt; Jørn Nerup; Flemming Pociot
Application of genomics and proteomics in Type 1 diabetes pathogenesis research.
Expert review of molecular diagnostics 2003;3(6):743-57.
2003: Stefan Johansson; Benedicte Lie; Anne Cambon-Thomsen; Flemming Pociot; Jørn Nerup; Ingrid Kockum; Erik Thorsby; DAG UNDLIEN
No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex.
Human immunology 2003;64(10):951-9.
2003: Ole P Kristiansen; Runa Louise Nolsoe; Lykke Larsen; Anette M P Gjesing; Jesper Johannesen; Zenia Marian Larsen; Anne E Lykkesfeldt; Allan E Karlsen; Flemming Pociot; Thomas Mandrup-Poulsen
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.
Human molecular genetics 2003;12(10):1101-10.
2003: Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Sif G Roenn; Jørn Nerup
Strain dependent rat iNOS promoter activity--correlation to identified WT1 transcription factor binding site.
Autoimmunity 2003;36(3):167-75.
2003: S Johansson; Benedicte Lie; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Ingrid Kockum; Erik Thorsby; DAG UNDLIEN
HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.
Tissue antigens 2003;61(5):344-51.
2003: Thomas Sparre; Anne M Ejrnaes Sprinkel; Ulla Bjerre Christensen; Allan E Karlsen; Flemming Pociot; Jørn Nerup
Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats.
Autoimmunity 2003;36(2):99-109.
2003: S Johansson; Benedicte Lie; J A Todd; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Ingrid Kockum; Hanne E Akselsen; Erik Thorsby; DAG UNDLIEN
Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.
Genes and immunity 2003;4(1):46-53.
2002: Flemming Pociot
CTLA4 gene and autoimmune endocrinopathies: a new marker?
Journal of endocrinological investigation 2002;25(11):1001-5.
2002: Thomas Sparre; Ulla Bjerre Christensen; P Mose Larsen; Stephen Fey; Krzysztof Wrzesinski; Peter Roepstorff; Thomas Mandrup-Poulsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup
IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis.
Diabetologia 2002;45(11):1550-61.
2002: T Gylvin; Regine Bergholdt; Jørn Nerup; Flemming Pociot
Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.
Genes and immunity 2002;3(7):430-2.
2002: L Leigh Field; Zenia Marian Larsen; Flemming Pociot; Jørn Nerup; Rose Tobias; Vagn Bonnevie-Nielsen
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.
Genes and immunity 2002;3(6):338-44.
2002: N Haukim; Jeffrey L Bidwell; A J P Smith; Leigh J Keen; G Gallagher; R Kimberly; T Huizinga; MF McDermott; J Oksenberg; J McNicholl; Flemming Pociot; C Hardt; S D'Alfonso
Cytokine gene polymorphism in human disease: on-line databases, supplement 2.
Genes and immunity 2002;3(6):313-30.
2002: Flemming Pociot; M F McDermott
Genetics of type 1 diabetes mellitus.
Genes and immunity 2002;3(5):235-49.
2002: Flemming Pociot; Allan E Karlsen
Combined genome and proteome approach to identify new susceptibility genes.
American journal of medical genetics 2002;115(1):55-60.
2002: Runa Louise Nolsoe; Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Flemming Pociot; Thomas Mandrup-Poulsen
Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families.
Diabetologia 2002;45(1):134-9.
2001: Zenia Marian Larsen; Anna D'Angelo; M Cattaneo; Jørn Nerup; Ida Biunno; Massimo Zollo; Flemming Pociot
Complete mutation scanning of the human SEL 1L gene: a candidate gene for type 1 diabetes.
Acta diabetologica 2001;38(4):191-2.
2001: J Nerup; Flemming Pociot
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.
American journal of human genetics 2001;69(6):1301-13.
2001: Peter E Heding; Allan E Karlsen; Riitta Veijola; Jørn Nerup; Flemming Pociot
No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families.
Genes and immunity 2001;2(7):398-400.
2001: Allan E Karlsen; Sif G Rønn; Karen Lindberg; Jesper Johannesen; Elisabeth D Galsgaard; Flemming Pociot; Jens H Nielsen; Thomas Mandrup-Poulsen; Jørn Nerup; Nils Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Jesper Johannesen; Flemming Pociot; Allan E Karlsen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression.
European cytokine network 2001;12(3):501-9.
2001: Flemming Pociot; Zenia Marian Larsen; Patrizia Zavattari; Elisabetta Deidda; Jørn Nerup; M Cattaneo; Raffaella Chiaramonte; Paola Comi; M Sabbadini; Massimo Zollo; Ida Biunno; Francesco Cucca
No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.
Diabetes/metabolism research and reviews 2001;17(4):292-5.
2001: Jesper Johannesen; A Pie; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(6):2792-6.
2001: Peter Mose Larsen; Stephen Fey; Martin R Larsen; Artur Nawrocki; HU Andersen; H Kähler; C Heilmann; M C Voss; Peter Roepstorff; Flemming Pociot; Allan E Karlsen; Jørn Nerup
Proteome analysis of interleukin-1beta--induced changes in protein expression in rat islets of Langerhans.
Diabetes 2001;50(5):1056-63.
2001: Jeffrey Bidwell; Leigh J Keen; G Gallagher; R Kimberly; T Huizinga; MF McDermott; J Oksenberg; J McNicholl; Flemming Pociot; C Hardt; S D'Alfonso
Cytokine gene polymorphism in human disease: on-line databases, supplement 1.
Genes and immunity 2001;2(2):61-70.
2001: Allan E Karlsen; Thomas Sparre; K Nielsen; Jørn Nerup; Flemming Pociot
Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus.
Disease markers 2001;17(4):205-16.
2001: Jan N Jensen; Lars Hansen; Claus T Ekstrøm; Flemming Pociot; J Nerup; Torben Hansen; Oluf Pedersen
Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population.
Diabetologia 2001;44(1):123-6.
2001: T R Merriman; H J Cordell; I A Eaves; P A Danoy; F Coraddu; R Barber; F Cucca; S Broadley; S Sawcer; A Compston; P Wordsworth; J Shatford; S Laval; J Jirholt; R Holmdahl; A N Theofilopoulos; D H Kono; J Tuomilehto; E Tuomilehto-Wolf; R Buzzetti; M G Marrosu; DAG UNDLIEN; K S Rønningen; C Ionesco-Tirgoviste; J P Shield; Flemming Pociot; J Nerup; C O Jacob; C Polychronakos; S C Bain; J A Todd
Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.
Diabetes 2001;50(1):184-94.
2000: Regine Bergholdt; Zenia Marian Larsen; NA Andersen; Jesper Johannesen; Ole P Kristiansen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level.
Genes and immunity 2000;1(8):495-500.
2000: Ole P Kristiansen; Runa Louise Nolsoe; H Holst; Sine Reker Hadrup; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Flemming Pociot; Thomas Mandrup-Poulsen
The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes.
Immunogenetics 2000;52(1-2):107-11.
2000: NE John; HU Andersen; Stephen Fey; Peter Mose Larsen; Peter Roepstorff; Martin R Larsen; Flemming Pociot; Allan E Karlsen; Jørn Nerup; Irene C Green; Thomas Mandrup-Poulsen
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
Diabetes 2000;49(11):1819-29.
2000: Jesper Johannesen; Flemming Pociot; Ole P Kristiansen; Allan E Karlsen; Jørn Nerup
No evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population.
Genes and immunity 2000;1(6):362-6.
2000: Runa Louise Nolsoe; Ole P Kristiansen; K Sangthongpitag; Zenia Marian Larsen; Jesper Johannesen; Allan E Karlsen; Flemming Pociot; Jørn Nerup; CF Verge; Thomas Mandrup-Poulsen
Complete molecular scanning of the human Fas gene: mutational analysis and linkage studies in families with type I diabetes mellitus. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Diabetologia 2000;43(6):800-8.
2000: L Hansen; Jan N Jensen; S Urioste; Helle Vestergaard Petersen; Flemming Pociot; Hans Eiberg; O P Kristiansen; Torben Hansen; Palle Serup; J Nerup; Oluf Pedersen
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.
Diabetes 2000;49(5):876-8.
2000: J Johannesen; L Tarnow; H H Parving; J Nerup; Flemming Pociot
CCTTT-repeat polymorphism in the human NOS2-promoter confers low risk of diabetic nephropathy in type 1 diabetic patients.
Diabetes care 2000;23(4):560-2.
2000: Ole P Kristiansen; Flemming Pociot; E P Bennett; H Clausen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen
IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group.
Human mutation 2000;15(3):295-6.
2000: Ole P Kristiansen; Zenia Marian Larsen; Flemming Pociot
CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?
Genes and immunity 2000;1(3):170-84.
2000: Allan E Karlsen; D Pavlovic; K Nielsen; J Jensen; HU Andersen; Flemming Pociot; Thomas Mandrup-Poulsen; Decio L Eizirik; Jørn Nerup
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.
The Journal of clinical endocrinology and metabolism 2000;85(2):830-6.
2000: Ole P Kristiansen; Flemming Pociot; Jesper Johannesen; Regine Bergholdt; C A Dinarello; Jørn Nerup; Thomas Mandrup-Poulsen
Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus.
Cytokine 2000;12(2):171-5.
1999: Jeffrey Bidwell; Leigh J Keen; G Gallagher; R Kimberly; T Huizinga; MF McDermott; J Oksenberg; J McNicholl; Flemming Pociot; C Hardt; S D'Alfonso
Cytokine gene polymorphism in human disease: on-line databases.
Genes and immunity 1999;1(1):3-19.
1999: B Freiesleben De Blasio; P Bak; Flemming Pociot; A E Karlsen; J Nerup
Onset of type 1 diabetes: a dynamical instability.
Diabetes 1999;48(9):1677-85.
1999: T Lorenzen; Flemming Pociot; Jesper Johannesen; Ole P Kristiansen; Jørn Nerup
A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(6):472-6.
1999: Benedicte Lie; J A Todd; Flemming Pociot; Jørn Nerup; Hanne E Akselsen; Geir Joner; Knut Dahl-Jørgensen; Kjersti S Rønningen; Erik Thorsby; DAG UNDLIEN
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.
American journal of human genetics 1999;64(3):793-800.
1999: T Lorenzen; Flemming Pociot; L S Stilgren; Ole P Kristiansen; Jesper Johannesen; P B Olsen; A Walmar; A V Larsen; N C Albrechtsen; P C Eskildsen; O O Andersen; J Nerup
[Markers for risk of IDDM in children of Danish patients with IDDM. A population-based, historical prospective study].
Ugeskrift for laeger 1999;161(7):953-8.
1999: Zenia Marian Larsen; Ole P Kristiansen; E Mato; Jesper Johannesen; M Puig-Domingo; Alberto de Leiva; Jørn Nerup; Flemming Pociot
IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).
Autoimmunity 1999;31(1):35-42.
1999: Ole P Kristiansen; Zenia Marian Larsen; Jesper Johannesen; Jørn Nerup; Thomas Mandrup-Poulsen; Flemming Pociot
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
Human mutation 1999;14(1):67-70.
1999: Guiomar Pérez de Nanclares; J Ramón Bilbao; Lorenza Nisticò; Raffaella Buzzetti; Zenia Marian Larsen; Flemming Pociot; Luis Castaño
No evidence of association of chromosome 2q with Type I diabetes in the Basque population.
Diabetologia 1999;42(1):119-20.
1998: AM Møller; Louise Torp Dalgaard; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia 1998;41(12):1528-31.
1998: Flemming Pociot; PM Hansen; Allan E Karlsen; B L Langdahl; Jesper Johannesen; Jørn Nerup
TGF-beta1 gene mutations in insulin-dependent diabetes mellitus and diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 1998;9(12):2302-7.
1998: L Esposito; N J Hill; L E Pritchard; Francesco Cucca; CE Muxworthy; Marilyn E Merriman; A Wilson; Cécile Julier; M Delepine; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; L Nistico'; Raffaella Buzzetti; Paolo Pozzilli; M Ferrari; Emanuele Bosi; Flemming Pociot; Jørn Nerup; SC Bain; John A Todd
Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group.
Diabetes 1998;47(11):1797-9.
1998: Y Nakagawa; Y Kawaguchi; Rebecca C J Twells; CE Muxworthy; Kara M Hunter; A Wilson; Marilyn E Merriman; Roger D Cox; Tony R Merriman; Francesco Cucca; PA McKinney; Julian P H Shield; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Lorenza Nisticò; R Buzzetti; Paolo Pozzilli; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; K S Rönningen; SC Bain; John A Todd
Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13.
American journal of human genetics 1998;63(2):547-56.
1998: Henrik B Mortensen; Thomas Mandrup-Poulsen; Bendt Brock Jacobsen; Mariane Rix; S Krabbe; K Borch-Johnsen; Flemming Pociot; D P Selskab
[Cow's milk-based infant formula to newborns of parents with insulin-dedent diabetes].
Ugeskrift for laeger 1998;160(27):4083-4.
1998: T Lorenzen; Flemming Pociot; L Stilgren; Ole P Kristiansen; Jesper Johannesen; P B Olsen; A Walmar; A Larsen; N C Albrechtsen; P C Eskildsen; O O Andersen; Jørn Nerup
Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Danish IDDM Epidemiology and Genetics Group.
Diabetologia 1998;41(6):666-73.
1998: Sandra D'Alfonso; I Borelli; Anna Maria Dall'Omo; Elisabetta Bolognesi; Jukka Partanen; A Levo; Flemming Pociot; L Fan; T Juji; M Hammond; Roberto Tosi; PM Richiardi
The natural history of an HLA haplotype and its recombinants.
Immunogenetics 1998;48(1):8-15.
1998: Tony R Merriman; Iain A Eaves; Rebecca C J Twells; Marilyn E Merriman; Patrick Danoy; CE Muxworthy; Kara M Hunter; Roger D Cox; Francesco Cucca; PA McKinney; Julian P H Shield; JD Baum; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; C Ionesco-Tirgoviste; Geir Joner; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; Kjersti S Ronningen; SC Bain; John A Todd
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6).
Human molecular genetics 1998;7(3):517-24.
1998: Ole P Kristiansen; M Zamani; Jesper Johannesen; Thomas Mandrup-Poulsen; J J Cassiman; Jørn Nerup; Flemming Pociot
Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.
Diabetes 1998;47(2):281-3.
1997: Simon T Bennett; AJ Wilson; L Esposito; N Bouzekri; DAG UNDLIEN; Francesco Cucca; Lorenza Nisticò; R Buzzetti; E Bosi; Flemming Pociot; Jørn Nerup; Anne Cambon-Thomsen; Alberto Pugliese; Julian P H Shield; PA McKinney; SC Bain; Constantin Polychronakos; John A Todd
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.
Nature genetics 1997;17(3):350-2.
1997: Jesper Johannesen; Allan E Karlsen; Jørn Nerup; Flemming Pociot
No association or linkage to IDDM of an interferon regulatory factor-1 gene polymorphism in a Danish population. The Danish Study Group for Diabetes in Childhood.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1997;24(5):377-83.
1997: PM Hansen; T Chowdhury; T Deckert; A Hellgren; S C Bain; Flemming Pociot
Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene). Association with urinary albumin excretion in IDDM patients.
Diabetes 1997;46(10):1658-9.
1997: Tony R Merriman; Rebecca C J Twells; Marilyn E Merriman; Iain A Eaves; R Cox; Francesco Cucca; Patricia McKinney; Julian P H Shield; D Baum; E Bosi; P Pozzilli; Lorenza Nisticò; Raffaella Buzzetti; Geir Joner; K S Rønningen; K Rønningen; Erik Thorsby; DAG UNDLIEN; Flemming Pociot; Jørn Nerup; S Bain; A Barnett; J Todd
Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.
Human molecular genetics 1997;6(7):1003-10.
1997: Lise Tarnow; Flemming Pociot; PM Hansen; Peter Rossing; Flemming S Nielsen; Birgitte V Hansen; Hans-Henrik Parving
Polymorphisms in the interleukin-1 gene cluster do not contribute to the genetic susceptibility of diabetic nephropathy in Caucasian patients with IDDM.
Diabetes 1997;46(6):1075-6.
1997: Flemming Pociot; Riitta Veijola; Jesper Johannesen; PM Hansen; T Lorenzen; Allan E Karlsen; Helena Reijonen; Mikael Knip; Jørn Nerup
Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(2):87-93.
1997: T Rambrand; Flemming Pociot; K S Rønningen; K Rønningen; J Nerup; Birgitte K Michelsen
Genetic markers for glutamic acid decarboxylase do not predict insulin-dependent diabetes mellitus in pairs of affected siblings. The Danish Study Group of Diabetes in Childhood.
Human genetics 1997;99(2):177-85.
1997: J W Chen; PM Hansen; Lise Tarnow; A Hellgren; T Deckert; Flemming Pociot
Genetic variation of a collagen IV alpha 1-chain gene polymorphism in Danish insulin-dependent diabetes mellitus (IDDM) patients: lack of association to nephropathy and proliferative retinopathy.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(2):143-7.
1997: Marc Delépine; Flemming Pociot; C Habita; L Hashimoto; philippe froguel; J Rotter; A Cambon-Thomsen; I Deschamps; S Djoulah; J Weissenbach; Jørn Nerup; Mark Lathrop; Cécile Julier
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
American journal of human genetics 1997;60(1):174-87.
1996: M Zamani; Flemming Pociot; M Spaepen; Petra Raeymaekers; Jørn Nerup; Jean-Jacques Cassiman
Linkage and association of the HLA gene complex with IDDM in 81 Danish families: strong linkage between DR beta 1Lys71+ and IDDM.
Journal of medical genetics 1996;33(11):899-905.
1996: K A Metcalfe; Graham A Hitman; Flemming Pociot; R Bergholdt; Eva Tuomilehto-Wolf; J Tuomilehto; M Viswanathan; A Ramachandran; Jørn Nerup
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
Human immunology 1996;51(1):41-8.
1996: M Zamani; Flemming Pociot; Petra Raeymaekers; Jørn Nerup; Jean-Jacques Cassiman
Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population.
Human genetics 1996;98(4):491-6.
1996: Simon T Bennett; AJ Wilson; Francesco Cucca; Jørn Nerup; Flemming Pociot; P A McKinney; A H Barnett; S C Bain; John A Todd
IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.
Journal of autoimmunity 1996;9(3):415-21.
1996: Flemming Pociot
Insulin-dependent diabetes mellitus--a polygenic disorder?
Danish medical bulletin 1996;43(3):216-48.
1996: J I Reimers; HU Andersen; D Mauricio; Flemming Pociot; Allan E Karlsen; J S Petersen; Thomas Mandrup-Poulsen; Jørn Nerup
Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis.
Diabetes 1996;45(6):771-8.
1996: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):21-30.
1995: Thomas Mandrup-Poulsen; Jørn Nerup; J I Reimers; Flemming Pociot; HU Andersen; Allan E Karlsen; U Bjerre; R Bergholdt
Cytokines and the endocrine system. I. The immunoendocrine network.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(6):660-71.
1995: M Sandberg-Wollheim; Emilio Ciusani; Andrea Salmaggi; Flemming Pociot
An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 1995;1(3):181-5.
1995: R Bergholdt; Allan E Karlsen; Jesper Johannesen; PM Hansen; C A Dinarello; Jørn Nerup; Flemming Pociot
Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.
Cytokine 1995;7(7):727-33.
1995: Flemming Pociot; Sandra D'Alfonso; S Compasso; R Scorza; P M Richiardi
Functional analysis of a new polymorphism in the human TNF alpha gene promoter.
Scandinavian journal of immunology 1995;42(4):501-4.
1995: Simon T Bennett; A M Lucassen; S C Gough; E E Powell; DAG UNDLIEN; L E Pritchard; Marilyn E Merriman; Y Kawaguchi; MJ Dronsfield; Flemming Pociot
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.
Nature genetics 1995;9(3):284-92.
1995: A Worsaae; K Hejnaes; A Moody; J Ludvigsson; Flemming Pociot; T Lorenzen; Thomas Dyrberg
T cell proliferative responses to glutamic acid decarboxylase-65 in IDDM are negatively associated with HLA DR3/4.
Autoimmunity 1995;22(3):183-9.
1994: Thomas Mandrup-Poulsen; Flemming Pociot; J Mølvig; L Shapiro; P Nilsson; T Emdal; ME Røder; L L Kjems; C A Dinarello; Jørn Nerup
Monokine antagonism is reduced in patients with IDDM.
Diabetes 1994;43(10):1242-7.
1994: Jørn Nerup; Thomas Mandrup-Poulsen; S Helqvist; HU Andersen; Flemming Pociot; J I Reimers; B G Cuartero; Allan E Karlsen; U Bjerre; T Lorenzen
On the pathogenesis of IDDM.
Diabetologia 1994;37 Suppl 2():S82-9.
1994: K Nørgaard; Flemming Pociot; N Hobolth; O Andersen; Jørn Nerup
[Familial aggregation of insulin-dependent diabetes mellitus in Denmark. A nation-wide population study].
Ugeskrift for laeger 1994;156(33):4710-3.
1994: T Lorenzen; Flemming Pociot; Philip Hougaard; Jørn Nerup
Long-term risk of IDDM in first-degree relatives of patients with IDDM.
Diabetologia 1994;37(3):321-7.
1994: J I Reimers; HU Andersen; Flemming Pociot
[Nicotinamide and prevention of insulin-dependent diabetes mellitus. Rationale, effects, toxicology and clinical experiences. ENDIT Group].
Ugeskrift for laeger 1994;156(4):461-5.
1994: P M van Endert; Roland S Liblau; SD Patel; Lars Fugger; T Lopez; Flemming Pociot; J Nerup; Hugh McDevitt
Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM.
Diabetes 1994;43(1):110-7.
1994: Flemming Pociot; K S Rønningen; R Bergholdt; T Lorenzen; Jesper Johannesen; K Ye; C A Dinarello; Jørn Nerup
Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Autoimmunity 1994;19(3):169-78.
1993: Thomas Mandrup-Poulsen; J I Reimers; HU Andersen; Flemming Pociot; Allan E Karlsen; U Bjerre; Jørn Nerup
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1993;9(4):295-309.
1993: Flemming Pociot; T Lorenzen; Jørn Nerup
A manganese superoxide dismutase (SOD2) gene polymorphism in insulin-dependent diabetes mellitus.
Disease markers 1993;11(5-6):267-74.
1993: Flemming Pociot; A G Wilson; Jørn Nerup; G W Duff
No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(11):3050-3.
1993: B Crouau-Roy; L Briant; C Bouissou; C Stravropoulos; Flemming Pociot; Anne Cambon-Thomsen; J Clayton
Tumor necrosis factor microsatellites in four European populations.
Human immunology 1993;38(3):213-6.
1993: Flemming Pociot; K S Rønningen; Jørn Nerup
Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM).
Scandinavian journal of immunology 1993;38(5):491-5.
1993: Flemming Pociot; K Nørgaard; N Hobolth; O Andersen; Jørn Nerup
A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. Danish Study Group of Diabetes in Childhood.
Diabetologia 1993;36(9):870-5.
1993: U Zumsteg; J I Reimers; Flemming Pociot; L Mørch; S Helqvist; M Brendel; Rodolfo Alejandro; Thomas Mandrup-Poulsen; C A Dinarello; Jørn Nerup
Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats.
Diabetologia 1993;36(8):759-66.
1993: Flemming Pociot; J I Reimers; HU Andersen
Nicotinamide--biological actions and therapeutic potential in diabetes prevention. IDIG Workshop, Copenhagen, Denmark, 4-5 December 1992.
Diabetologia 1993;36(6):574-6.
1993: Thomas Mandrup-Poulsen; U Zumsteg; J Reimers; Flemming Pociot; L Mørch; S Helqvist; C A Dinarello; Jørn Nerup
Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus.
Cytokine 1993;5(3):185-91.
1993: A G Wilson; Niek de Vries; Flemming Pociot; Francesco S Di Giovine; L B van der Putte; Gordon W Duff
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
The Journal of experimental medicine 1993;177(2):557-60.
1993: Susanne Lanng; B Thorsteinsson; Flemming Pociot; M O Marshall; Hans O Madsen; Marianne Schwartz; Jørn Nerup; Christian Koch
Diabetes mellitus in cystic fibrosis: genetic and immunological markers.
Acta paediatrica (Oslo, Norway : 1992) 1993;82(2):150-4.
1993: Flemming Pociot; L Briant; Victor Jongeneel; J Mölvig; H Worsaae; M Abbal; M Thomsen; Jørn Nerup; Anne Cambon-Thomsen
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.
European journal of immunology 1993;23(1):224-31.
1992: Jorma Ilonen; H Merivuori; Helena Reijonen; Mikael Knip; Hans K Akerblom; Flemming Pociot; J Nerup
Tumour necrosis factor-beta gene RFLP alleles in Finnish IDDM haplotypes. The Childhood Diabetes in Finland (DiMe) Study Group.
Scandinavian journal of immunology 1992;36(6):779-83.
1992: Flemming Pociot; J Mølvig; L Wogensen; H Worsaae; Jørn Nerup
A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro.
European journal of clinical investigation 1992;22(6):396-402.
1991: J Mølvig; Flemming Pociot; H Worsaae; L D Wogensen; L Baek; P Christensen; Thomas Mandrup-Poulsen; K Andersen; P Madsen; J Dyerberg
Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals.
Scandinavian journal of immunology 1991;34(4):399-410.
1991: Flemming Pociot; J Mølvig; L Wogensen; H Worsaae; H Dalbøge; L Baek; Jørn Nerup
A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus.
Scandinavian journal of immunology 1991;33(1):37-49.
1990: J Mølvig; Flemming Pociot; L Baek; H Worsaae; L Dall Wogensen; P Christensen; L Staub-Nielsen; Thomas Mandrup-Poulsen; K Manogue; Jørn Nerup
Monocyte function in IDDM patients and healthy individuals.
Scandinavian journal of immunology 1990;32(3):297-311.
1990: L Wogensen; S Helqvist; Flemming Pociot; Jesper Johannesen; J Reimers; Thomas Mandrup-Poulsen; Jørn Nerup
Intra-peritoneal administration of interleukin-1 beta induces impaired insulin release from the perfused rat pancreas.
Autoimmunity 1990;7(1):1-12.
1990: Thomas Mandrup-Poulsen; S Helqvist; L D Wogensen; J Mølvig; Flemming Pociot; Jesper Johannesen; Jørn Nerup
Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells.
Current topics in microbiology and immunology 1990;164():169-93.
1986: Flemming Pociot; H H Storm; E Lynge
[Mammographic examinations in Denmark in 1984].
Ugeskrift for laeger 1986;148(8):471-4.
1983: T Hansen; O Kiehn; J Kristensen; J E Larsen; T Lorenzen; Flemming Pociot; M Rathcke; M Norn
[Schirmer's tear test].
Ugeskrift for laeger 1983;145(34):2573-5.