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Tarek Shalaby

Research Profile

Disorders

Anatomy

Tumor Cell Line

Physiology

Chemicals & Drugs

Living Beings

Infants

Procedures

Reverse Transcriptase Polymerase Chain Reaction

Co-author Network

Publications

TOP 3
Danielle Boller; Angela De Laurentiis; Olivier Delattre; Paul Depledge; Kathrin T Doepfner; Sarah Fattet; Karl Frei; Michael A Grotzer; Ana S Guerreiro; Masahiko Hayakawa; Katrin Höland; Hiroyuki Kaizawa; Tomonobu Koizumi; Marin Marinov; Takahide Ohishi; Anthony Robson; Nahid Saghir; Anelia Schweri-Olac; Tarek Shalaby; Olivier Spertini; Michael D Waterfield; Alexandre Arcaro
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
Sheng-Qing Lv; Sumihito Nobusawa; Fiaschetti Giulio; Michael A Grotzer; Young-Ho Kim; Tarek Shalaby; Hui Yang; Zheng Zhou; Hiroko Ohgaki
Genetic alterations in microRNAs in medulloblastomas.
Anna Wojtalla; Ditte G Christiansen; Tiziana Cremona; Paulina Cwiek; Nicole Gross; Michael A Grotzer; Fabiana Salm; Tarek Shalaby; Alexandre Arcaro
Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma.

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All Publications

2012: Danielle Boller; Angela De Laurentiis; Olivier Delattre; Paul Depledge; Kathrin T Doepfner; Sarah Fattet; Karl Frei; Michael A Grotzer; Ana S Guerreiro; Masahiko Hayakawa; Katrin Höland; Hiroyuki Kaizawa; Tomonobu Koizumi; Marin Marinov; Takahide Ohishi; Anthony Robson; Nahid Saghir; Anelia Schweri-Olac; Tarek Shalaby; Olivier Spertini; Michael D Waterfield; Alexandre Arcaro
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
Anticancer research 2012;32(8):3015-27.
2012: Sheng-Qing Lv; Sumihito Nobusawa; Fiaschetti Giulio; Michael A Grotzer; Young-Ho Kim; Tarek Shalaby; Hui Yang; Zheng Zhou; Hiroko Ohgaki
Genetic alterations in microRNAs in medulloblastomas.
Brain pathology (Zurich, Switzerland) 2012;22(2):230-9.
2012: Anna Wojtalla; Ditte G Christiansen; Tiziana Cremona; Paulina Cwiek; Nicole Gross; Michael A Grotzer; Fabiana Salm; Tarek Shalaby; Alexandre Arcaro
Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma.
PloS one 2012;7(10):e47109.
2011: Eveline Grunder; Sheng-Qing Lv; Hiroko Ohgaki; Tarek Shalaby; Tycho Zuzak; Lucia Abela; Alexandre Arcaro; Rocco D'Ambrosio; Giulio Fiaschetti; Michael A Grotzer
MicroRNA-21 suppression impedes medulloblastoma cell migration.
European journal of cancer (Oxford, England : 1990) 2011;47(16):2479-90.
2011: Ana S Guerreiro; Shaun P Jackson; Dorota W Kulesza; Simone M Schoenwaelder; Tarek Shalaby; Abdullah Atamer; Olivier Delattre; Alexandra N Elsing; Sarah Fattet; Michael A Grotzer; Alexandre Arcaro
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.
Molecular cancer research : MCR 2011;9(7):925-35.
2011: G Fiaschetti; Alexandre Arcaro; D Castelletti; Angelika Eggert; M Mittelbronn; M Nagaishi; H Ohgaki; Martin Pruschy; A Schramm; C Schroeder; Tarek Shalaby; duncan stearns; F Westermann; S Zoller; Michael A Grotzer
Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma.
Oncogene 2011;30(25):2823-35.
2011: Denis Faoro; André O von Bueren; Tarek Shalaby; Davide Sciuscio; Marie-Louise Hürlimann; Lucia Arnold; Nicolas U Gerber; Johannes Haybaeck; Michel Mittelbronn; Stefan Rutkowski; Monika Hegi; Michael A Grotzer
Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.
Journal of neuro-oncology 2011;103(1):59-69.
2011: André O von Bueren; Christoph Oehler; Tarek Shalaby; Katja von Hoff; Martin Pruschy; Burkhardt Seifert; Nicolas U Gerber; Monika Warmuth-Metz; duncan stearns; Charles G Eberhart; Rolf D Kortmann; Stefan Rutkowski; Michael A Grotzer
c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients.
BMC cancer 2011;11():74.
2011: G Fiaschetti; Michael A Grotzer; Tarek Shalaby; D Castelletti; Alexandre Arcaro
Quassinoids: From traditional drugs to new cancer therapeutics.
Current medicinal chemistry 2011;18(3):316-28.
2011: Lucia Kuhn-Nentwig; Jean Willems; Thomas Seebeck; Tarek Shalaby; Marcel Kaiser; Wolfgang Nentwig
Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells.
Amino acids 2011;40(1):69-76.
2010: Deborah Castelletti; Giulio Fiaschetti; Valeria Di Dato; Urs Ziegler; Candy Kumps; Katleen De Preter; Massimo Zollo; Frank Speleman; Tarek Shalaby; Daniela De Martino; Thorsten Berg; Angelika Eggert; Alexandre Arcaro; Michael A Grotzer
The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors.
Molecular cancer therapeutics 2010;9(12):3145-57.
2010: Tarek Shalaby; André O von Bueren; Marie-Louise Hürlimann; Giulio Fiaschetti; Deborah Castelletti; Tera Masayuki; Kazuo Nagasawa; Alexandre Arcaro; Ilian Jelesarov; Kazuo Shin-ya; Michael A Grotzer
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.
Molecular cancer therapeutics 2010;9(1):167-79.
2009: Michael A Grotzer; Deborah Castelletti; Giulio Fiaschetti; Tarek Shalaby; Alexandre Arcaro
Targeting Myc in pediatric malignancies of the central and peripheral nervous system.
Current cancer drug targets 2009;9(2):176-88.
2009: André O von Bueren; Tarek Shalaby; Christoph Oehler-Jänne; Lucia Arnold; duncan stearns; Charles G Eberhart; Alexandre Arcaro; Martin Pruschy; Michael A Grotzer
RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.
BMC cancer 2009;9():10.
2008: Ana S Guerreiro; Sarah Fattet; Barbara Fischer; Tarek Shalaby; Shaun P Jackson; Simone M Schoenwaelder; Michael A Grotzer; Olivier Delattre; Alexandre Arcaro
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6761-9.
2008: Danielle Boller; Alexander Schramm; Kathrin T Doepfner; Tarek Shalaby; André O von Bueren; Angelika Eggert; Michael A Grotzer; Alexandre Arcaro
Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):1172-81.
2007: Michael A Grotzer; Katja von Hoff; André O von Bueren; Tarek Shalaby; W Hartmann; Monika Warmuth-Metz; Angela Emser; Rolf-Dieter Kortmann; Joachim Kuehl; Torsten Pietsch; Stefan Rutkowski
Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma.
Klinische Pädiatrie 2007;219(6):312-7.
2007: Sonja Junge; Barbara Kloeckener-Gruissem; Romain Zufferey; Andre Keisker; Bettina Salgo; Jean-Claude Fauchere; Franziska Scherer; Tarek Shalaby; Michael A Grotzer; Ulrich Siler; Reinhard Seger; Tayfun Güngör
Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children.
European journal of immunology 2007;37(11):3270-80.
2007: Alexandre Arcaro; Kathrin T Doepfner; Danielle Boller; Ana S Guerreiro; Tarek Shalaby; Shaun P Jackson; Simone M Schoenwaelder; Olivier Delattre; Michael A Grotzer; Barbara Fischer
Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.
The Biochemical journal 2007;406(1):57-66.
2007: N Meister; Tarek Shalaby; André O von Bueren; P Rivera; Ratnakar Patti; Christoph Oehler; Martin Pruschy; Michael A Grotzer
Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy.
European journal of cancer (Oxford, England : 1990) 2007;43(12):1833-41.
2007: J D'cunja; Tarek Shalaby; P Rivera; A von Büren; Ratnakar Patti; F L Heppner; Alexandre Arcaro; Lucy B Rorke-Adams; Peter C Phillips; Michael A Grotzer
Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells.
European journal of cancer (Oxford, England : 1990) 2007;43(10):1581-9.
2007: Stefan Rutkowski; André O von Bueren; Katja von Hoff; Wolfgang Hartmann; Tarek Shalaby; Frank Deinlein; Monika Warmuth-Metz; Niels Soerensen; Angela Emser; Udo Bode; Uwe Mittler; Christian Urban; Martin Benesch; Rolf-Dieter Kortmann; Paul G Schlegel; Joachim Kuehl; Torsten Pietsch; Michael A Grotzer
Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2651-7.
2007: André O von Bueren; Tarek Shalaby; Julia Rajtarova; duncan stearns; Charles G Eberhart; Lawrence Helson; Alexandre Arcaro; Michael A Grotzer
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells.
BMC cancer 2007;7():19.
2006: Ana S Guerreiro; Danielle Boller; Tarek Shalaby; Michael A Grotzer; Alexandre Arcaro
Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.
International journal of cancer. Journal international du cancer 2006;119(11):2527-38.
2006: Franzisca Kunz; Tarek Shalaby; Doris Lang; André von Büren; Johannes A Hainfellner; Irene Slavc; Ghazaleh Tabatabai; Michael A Grotzer
Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(5):393-9.
2005: N Binz; Tarek Shalaby; P Rivera; K Shin-ya; Michael A Grotzer
Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells.
European journal of cancer (Oxford, England : 1990) 2005;41(18):2873-81.
2004: Domenico Didiano; Tarek Shalaby; Doris Lang; Michael A Grotzer
Telomere maintenance in childhood primitive neuroectodermal brain tumors.
Neuro-oncology 2004;6(1):1-8.
2003: Carmen Pingoud-Meier; Doris Lang; Anna Janss; Lucy B Rorke; Peter C Phillips; Tarek Shalaby; Michael A Grotzer
Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6401-9.
2001: Tarek Shalaby; Matthias Liniger; Thomas Seebeck
The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei.
European journal of biochemistry / FEBS 2001;268(23):6197-206.
2001: Thomas Seebeck; KW Gong; Stefan Kunz; R Schaub; Tarek Shalaby; Roya Zoraghi
cAMP signalling in Trypanosoma brucei.
International journal for parasitology 2001;31(5-6):491-8.
2000: I Hunger-Glaser; Andrew Hemphill; Tarek Shalaby; M Hänni; Thomas Seebeck
Nucleoside diphosphate kinase of Trypanosoma brucei.
Gene 2000;257(2):251-7.