FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert Tuckey

Research Profile

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Edith K Y Tang; Elaine W Tieu; Jianjun Chen; Zorica Janjetovic; Wei Li; Andrzej T Slominski; Robert Tuckey
Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1.
Andrzej Slominski; Robert Tuckey; Jin Wang; Keka G Bhattacharya; Monica Brown; Weikuan Gu; Zorica Janjetovic; Yan Jiao; Wei Li; Minh N Nguyen; Arnold E Postlethwaite
20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo.
Elaine W Tieu; Jianjun Chen; Zorica Janjetovic; Wei Li; Minh N Nguyen; Andrzej Slominski; Edith K Y Tang; Robert Tuckey
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert Tuckey (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Edith K Y Tang; Elaine W Tieu; Jianjun Chen; Zorica Janjetovic; Wei Li; Andrzej T Slominski; Robert Tuckey
Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(5):1112-24.
2013: Andrzej Slominski; Robert Tuckey; Jin Wang; Keka G Bhattacharya; Monica Brown; Weikuan Gu; Zorica Janjetovic; Yan Jiao; Wei Li; Minh N Nguyen; Arnold E Postlethwaite
20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo.
The Journal of clinical endocrinology and metabolism 2013;98(2):E298-303.
2012: Elaine W Tieu; Jianjun Chen; Zorica Janjetovic; Wei Li; Minh N Nguyen; Andrzej Slominski; Edith K Y Tang; Robert Tuckey
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.
Biochemical pharmacology 2012;84(12):1696-704.
2012: Andrzej T Slominski; Trevor W Sweatman; Charles R Yates; Jianjun Chen; Zorica Janjetovic; Tae-Kang Kim; Wei Li; Minh N Nguyen; Robert Tuckey
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes.
The international journal of biochemistry & cell biology 2012;44(11):2003-18.
2012: Edith K Y Tang; Elaine W Tieu; Robert Tuckey
Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.
The FEBS journal 2012;279(19):3749-61.
2012: Tae-Kang Kim; Wei Li; Duane Miller; Minh N Nguyen; Jianjun Chen; Zorica Janjetovic; Edith K Y Tang; Robert Tuckey; Jin Wang; Andrzej T Slominski
Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.
Molecular and cellular endocrinology 2012;361(1-2):143-52.
2012: Andrzej T Slominski; Adam C Wright; Laura N Grese; Zorica Janjetovic; Tae-Kang Kim; Minh N Nguyen; Samuel J Riney; Robert Tuckey
Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes.
Anticancer research 2012;32(9):3733-42.
2012: Andrzej Slominski; Edith K Y Tang; Charles R Yates; Heather A E Benson; Jianjun Chen; Zorica Janjetovic; Tae-Kang Kim; Elena Korik; Wei Li; Minh N Nguyen; Arnold Postlethwaite; Igor Semak; Haleem Z Shehabi; Robert Tuckey
In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(9):3901-15.
2012: Yan Lu; Phillip Michaels; Jianjun Chen; Zorica Janjetovic; Wei Li; Andrzej T Slominski; Edith K Y Tang; Robert Tuckey; Jin Wang; Duane D Miller
Design, synthesis, and biological action of 20R-hydroxyvitamin D3.
Journal of medicinal chemistry 2012;55(7):3573-7.
2012: Elaine W Tieu; Donna M Baldisseri; Jianjun Chen; Wei Li; Andrzej T Slominski; Robert Tuckey
Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1.
The Journal of steroid biochemistry and molecular biology 2012;129(3-5):163-71.
2012: Jin Wang; Jianjun Chen; Zorica Janjetovic; Anand Kulkarni; Duane Miller; Arnold E Postlethwaite; Andrzej Slominski; Robert Tuckey; Wei Li
20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic.
Anticancer research 2012;32(3):739-46.
2012: Robert Tuckey; Jordan K Zjawiony; Donna M Baldisseri; Jianjun Chen; Minh N Nguyen; Andrzej Slominski; Elaine W Tieu; Wei Li
Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(3):436-44.
2012: Shelley Gorman; Michele A Grimbaldeston; Jacqueline L Bisley; Naomi M Scott; Daryl H W Tan; Robert Tuckey; Clare E Weeden; Prue H Hart
Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice.
PloS one 2012;7(9):e46006.
2011: Zorica Janjetovic; W Jozwicki; Tae-Kang Kim; Minh N Nguyen; Lawrence M Pfeffer; S R Pfeffer; Anna Brozyna; Robert Tuckey; A T Slominski
High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.
British journal of cancer 2011;105(12):1874-84.
2011: Robert Tuckey; Trevor W Sweatman; Donna M Baldisseri; Heather A E Benson; Jianjun Chen; Danielle E Howell; Zorica Janjetovic; Tae-Kang Kim; Wei Li; Minh N Nguyen; Haleem Z Shehabi; Andrzej Slominski
Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1577-88.
2011: Cezary Skobowiat; John C Dowdy; Robert M Sayre; Robert Tuckey; Andrzej Slominski
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation.
American journal of physiology. Endocrinology and metabolism 2011;301(3):E484-93.
2011: Andrzej Slominski; Wei Li; Syamal K Bhattacharya; Richard A Smith; Patti L Johnson; Jianjun Chen; Kathleen E Nelson; Robert Tuckey; Duane Miller; Yan Jiao; Weikuan Gu; Arnold E Postlethwaite
Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.
The Journal of investigative dermatology 2011;131(5):1167-9.
2011: Andrzej Slominski; Tae-Kang Kim; Zorica Janjetovic; Robert Tuckey; Radoslaw Bieniek; Junming Yue; Wei Li; Jianjun Chen; Minh N Nguyen; Edith K Y Tang; Duane Miller; Tai C Chen; Michael Holick
20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.
American journal of physiology. Cell physiology 2011;300(3):C526-41.
2010: Wei Li; Jianjun Chen; Zorica Janjetovic; Tae-Kang Kim; Trevor W Sweatman; Yan Lu; Jordan K Zjawiony; Robert Tuckey; Duane Miller; Andrzej Slominski
Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.
Steroids 2010;75(12):926-35.
2010: Edith K Y Tang; Wei Li; Zorica Janjetovic; Minh N Nguyen; Zhao Wang; Andrzej Slominski; Robert Tuckey
Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(9):1553-9.
2010: Edith K Y Tang; Kimberley J Q Voo; Minh N Nguyen; Robert Tuckey
Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1).
The Journal of steroid biochemistry and molecular biology 2010;119(3-5):171-9.
2010: Zorica Janjetovic; Robert Tuckey; Minh N Nguyen; Edwin M Thorpe; Andrzej Slominski
20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes.
Journal of cellular physiology 2010;223(1):36-48.
2010: Tae-Kang Kim; Jianjun Chen; Wei Li; Jordan K Zjawiony; Duane Miller; Zorica Janjetovic; Robert Tuckey; Andrzej Slominski
A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity.
Steroids 2010;75(3):230-9.
2010: Andrzej T Slominski; Zorica Janjetovic; Brian E Fuller; Michal Zmijewski; Robert Tuckey; Minh N Nguyen; Trevor W Sweatman; Wei Li; Jordan K Zjawiony; Duane Miller; Tai C Chen; Gerard Lozanski; Michael F Holick
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.
PloS one 2010;5(3):e9907.
2009: Minh N Nguyen; Andrzej Slominski; Wei Li; Yun Rui Ng; Robert Tuckey
Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):761-7.
2009: Zorica Janjetovic; Michal Zmijewski; Robert Tuckey; Damon A DeLeon; Minh N Nguyen; Lawrence M Pfeffer; Andrzej T Slominski
20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.
PloS one 2009;4(6):e5988.
2009: Andrzej T Slominski; Michal Zmijewski; Igor Semak; Trevor W Sweatman; Zorica Janjetovic; Wei Li; Jordan K Zjawiony; Robert Tuckey
Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin.
PloS one 2009;4(2):e4309.
2008: Robert Tuckey; Zorica Janjetovic; Wei Li; Minh N Nguyen; Michal A Zmijewski; Jordan Zjawiony; Andrzej Slominski
Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.
The Journal of steroid biochemistry and molecular biology 2008;112(4-5):213-9.
2008: Blazej Zbytek; Zorica Janjetovic; Robert Tuckey; Michal Zmijewski; Trevor W Sweatman; Emily Jones; Minh N Nguyen; Andrzej Slominski
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation.
The Journal of investigative dermatology 2008;128(9):2271-80.
2008: Robert Tuckey; Wei Li; Jordan K Zjawiony; Michal Zmijewski; Minh N Nguyen; Trevor Sweatman; Duane Miller; Andrzej Slominski
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc.
The FEBS journal 2008;275(10):2585-96.
2008: Robert Tuckey; Minh N Nguyen; Andrzej Slominski
Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.
The international journal of biochemistry & cell biology 2008;40(11):2619-26.
2007: Andrzej Slominski; Jacobo Wortsman; Robert Tuckey; Ralf Paus
Differential expression of HPA axis homolog in the skin.
Molecular and cellular endocrinology 2007;265-266():143-9.
2006: Andrzej Slominski; Igor Semak; Jacobo Wortsman; Jordan K Zjawiony; Wei Li; Blazej Zbytek; Robert Tuckey
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.
The FEBS journal 2006;273(13):2891-901.
2005: Andrzej Slominski; Igor Semak; Jordan K Zjawiony; Jacobo Wortsman; Michael N Gandy; Jinghu Li; Blazej Zbytek; Wei Li; Robert Tuckey
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol.
Chemistry & biology 2005;12(8):931-9.
2005: Andrzej Slominski; Igor Semak; Jordan K Zjawiony; Jacobo Wortsman; Wei Li; Andre Szczesniewski; Robert Tuckey
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.
The FEBS journal 2005;272(16):4080-90.
2005: Robert Tuckey
Progesterone synthesis by the human placenta.
Placenta 2005;26(4):273-81.
2004: Robert Tuckey; Himangshu Bose; Inez Czerwionka; Walter L Miller
Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.
Endocrinology 2004;145(4):1700-7.
2003: Madeleine J Headlam; Matthew C J Wilce; Robert Tuckey
The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane.
Biochimica et biophysica acta 2003;1617(1-2):96-108.
2003: Daniel Johnson; Shona Norman; Robert Tuckey; Lisandra L Martin
Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode.
Bioelectrochemistry (Amsterdam, Netherlands) 2003;59(1-2):41-7.
2002: Robert Tuckey; Madeleine J Headlam; Himangshu Bose; Walter L Miller
Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).
The Journal of biological chemistry 2002;277(49):47123-8.
2002: Madeleine J Headlam; Robert Tuckey
The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration.
Archives of biochemistry and biophysics 2002;407(1):95-102.
2002: Robert Tuckey; Madeleine J Headlam
Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase.
The Journal of steroid biochemistry and molecular biology 2002;81(2):153-8.
2001: Robert Tuckey; Allan J McKinley; Madeleine J Headlam
Oxidized adrenodoxin acts as a competitive inhibitor of cytochrome P450scc in mitochondria from the human placenta.
European journal of biochemistry / FEBS 2001;268(8):2338-43.
1999: Robert Tuckey; J Sadleir
The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta.
European journal of biochemistry / FEBS 1999;263(2):319-25.
1999: Pyotr Kisselev; Robert Tuckey; ST Woods; T Triantopoulos; Dieter Schwarz
Enzymatic properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin.
European journal of biochemistry / FEBS 1999;260(3):768-73.
1998: ST Woods; J Sadleir; T Downs; T Triantopoulos; Madeleine J Headlam; Robert Tuckey
Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.
Archives of biochemistry and biophysics 1998;353(1):109-15.
1997: Robert Tuckey; ST Woods; M Tajbakhsh
Electron transfer to cytochrome P-450scc limits cholesterol-side-chain-cleavage activity in the human placenta.
European journal of biochemistry / FEBS 1997;244(3):835-9.
1996: Robert Tuckey; J Lawrence; K J Cameron
Side-chain cleavage of cholesterol esters by human cytochrome P-450(scc).
The Journal of steroid biochemistry and molecular biology 1996;58(5-6):605-10.
1994: Robert Tuckey; Z Kostadinovic; K J Cameron
Cytochrome P-450scc activity and substrate supply in human placental trophoblasts.
Molecular and cellular endocrinology 1994;105(2):123-9.
1994: Robert Tuckey; Z Kostadinovic; K J Cameron
Cytochrome P-450scc activity and substrate supply in human placental trophoblasts.
Molecular and cellular endocrinology 1994;105(1):103-9.
1994: G T Jennings; S Sechi; P M Stevenson; Robert Tuckey; D Parmelee; Lee McAlister-Henn
Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA.
The Journal of biological chemistry 1994;269(37):23128-34.
1993: Robert Tuckey; K J Cameron
Side-chain specificities of human and bovine cytochromes P-450scc.
European journal of biochemistry / FEBS 1993;217(1):209-15.
1993: Robert Tuckey; K J Cameron
Catalytic properties of cytochrome P-450scc purified from the human placenta: comparison to bovine cytochrome P-450scc.
Biochimica et biophysica acta 1993;1163(2):185-94.
1993: Robert Tuckey; K J Cameron
Human placental cholesterol side-chain cleavage: enzymatic synthesis of (22R)-20 alpha,22-dihydroxycholesterol.
Steroids 1993;58(5):230-3.
1992: Robert Tuckey
Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates.
The Journal of steroid biochemistry and molecular biology 1992;42(8):883-90.
1990: Robert Tuckey
Side-chain cleavage of cholesterol sulfate by ovarian mitochondria.
The Journal of steroid biochemistry and molecular biology 1990;37(1):121-7.
1989: Robert Tuckey; H C Atkinson
Pregnenolone synthesis from cholesterol and hydroxycholesterols by mitochondria from ovaries following the stimulation of immature rats with pregnant mare's serum gonadotropin and human choriogonadotropin.
European journal of biochemistry / FEBS 1989;186(1-2):255-9.
1989: Robert Tuckey; J W Holland
Comparison of pregnenolone synthesis by cytochrome P-450scc in mitochondria from porcine corpora lutea and granulosa cells of follicles.
The Journal of biological chemistry 1989;264(10):5704-9.
1988: Robert Tuckey; Z Kostadinovic; P M Stevenson
Ferredoxin and cytochrome P-450scc concentrations in granulosa cells of porcine ovaries during follicular cell growth and luteinization.
Journal of steroid biochemistry 1988;31(2):201-5.
1986: Robert Tuckey; P M Stevenson
Ferredoxin reductase levels in the ovaries of pigs and superovulated rats during follicular cell growth and luteinization.
European journal of biochemistry / FEBS 1986;161(3):629-33.
1985: Robert Tuckey; P M Stevenson
Purification and analysis of phospholipids in the inner mitochondrial membrane fraction of bovine corpus luteum, and properties of cytochrome P-450scc incorporated into vesicles prepared from these phospholipids.
European journal of biochemistry / FEBS 1985;148(2):379-84.
1985: M L O'Meara; Robert Tuckey; P M Stevenson
A comparison of the lipid classes and essential fatty acid content of rat plasma lipoproteins and ovary.
The International journal of biochemistry 1985;17(9):1027-30.
1984: Robert Tuckey; G Lee; N D Costa; P M Stevenson
The composition and distribution of lipid granules in the rat ovary.
Molecular and cellular endocrinology 1984;38(2-3):187-95.
1984: Robert Tuckey; P M Stevenson
Properties of bovine luteal cytochrome P-450scc incorporated into artificial phospholipid vesicles.
The International journal of biochemistry 1984;16(5):497-503.
1984: Robert Tuckey; P M Stevenson
Properties of ferredoxin reductase and ferredoxin from the bovine corpus luteum.
The International journal of biochemistry 1984;16(5):489-95.
1983: Robert Tuckey; H Kamin
Kinetics of O2 and CO Binding to adrenal cytochrome P-450scc. Effect of cholesterol, intermediates, and phosphatidylcholine vesicles.
The Journal of biological chemistry 1983;258(7):4232-7.
1982: Robert Tuckey; H Kamin
The oxyferro complex of adrenal cytochrome P-450scc. Effect of cholesterol and intermediates on its stability and optical characteristics.
The Journal of biological chemistry 1982;257(16):9309-14.
1982: Robert Tuckey; H Kamin
Kinetics of the incorporation of adrenal cytochrome P-450scc into phosphatidylcholine vesicles.
The Journal of biological chemistry 1982;257(6):2887-93.
1982: David J. Lambeth; S E Kitchen; A A Farooqui; Robert Tuckey; H Kamin
Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols.
The Journal of biological chemistry 1982;257(4):1876-84.
1980: Robert Tuckey; P M Stevenson
Triacylglycerols and glycerophospholipids in ovaries from maturing and superovulated immature rats.
Australian journal of biological sciences 1980;33(4):431-40.
1980: Robert Tuckey; P M Stevenson
Cholesteryl esterase and endogenous cholesteryl ester pools in ovaries from maturing and superovulated immature rats.
Biochimica et biophysica acta 1980;618(3):501-9.
1979: Robert Tuckey; P M Stevenson
Free and esterified cholesterol concentration and cholesteryl ester composition in the ovaries of maturing and superovulated immature rats.
Biochimica et biophysica acta 1979;575(1):46-56.
1979: Robert Tuckey; P M Stevenson
Methanolysis of cholesteryl esters: conditions for quantitative preparation of methyl esters.
Analytical biochemistry 1979;94(2):402-8.