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McHardy Smith

Research Profile

Chemicals & Drugs

Living Beings

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Disorders

Pain

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Publications

TOP 3
Andrew M Swensen; Vivien A Warren; David Parker; Kevin S Ratliff; McHardy Smith; Terrance P Snutch; Stephen P Arneric; Randal M Bugianesi; Ge Dai; Joseph L Duffy; Cyrus Eduljee; Rodolfo J Haedo; James Herrington; Scott B Hoyt; Gregory J Kaczorowski; Clare London; Owen B McManus
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels.
S Tyagarajan; Prasun K Chakravarty; Min Park; Bishan Zhou; James B Herrington; Kevin Ratliff; Randal M Bugianesi; Brande Williams; Rodolfo J Haedo; Andrew M Swensen; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; Owen B McManus; Kathryn A Lyons; Xiaohua Li; Maria Madeira; Bindhu V Karanam; Mitchell Green; Michael J Forrest; Catherine Abbadie; Erin McGowan; Shruti Mistry; Nina Jochnowitz; Joseph L Duffy
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.

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All Publications

2012: Andrew M Swensen; Vivien A Warren; David Parker; Kevin S Ratliff; McHardy Smith; Terrance P Snutch; Stephen P Arneric; Randal M Bugianesi; Ge Dai; Joseph L Duffy; Cyrus Eduljee; Rodolfo J Haedo; James Herrington; Scott B Hoyt; Gregory J Kaczorowski; Clare London; Owen B McManus
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels.
Molecular pharmacology 2012;81(3):488-97.
2011: S Tyagarajan; Prasun K Chakravarty; Min Park; Bishan Zhou; James B Herrington; Kevin Ratliff; Randal M Bugianesi; Brande Williams; Rodolfo J Haedo; Andrew M Swensen; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; Owen B McManus; Kathryn A Lyons; Xiaohua Li; Maria Madeira; Bindhu V Karanam; Mitchell Green; Michael J Forrest; Catherine Abbadie; Erin McGowan; Shruti Mistry; Nina Jochnowitz; Joseph L Duffy
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorganic & medicinal chemistry letters 2011;21(2):869-73.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 2010;20(24):7479-82.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5536-40.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5480-3.
2010: Catherine Abbadie; Owen B McManus; Shu-Yu Sun; Randal M Bugianesi; Ge Dai; Rodolfo J Haedo; James B Herrington; Gregory J Kaczorowski; McHardy Smith; Andrew M Swensen; Vivien A Warren; Brande Williams; Stephen P Arneric; Cyrus Eduljee; Terrance P Snutch; Elizabeth W Tringham; Nina Jochnowitz; Annie Liang; D Euan MacIntyre; Erin McGowan; Shruti Mistry; Valerie V White; Scott B Hoyt; Clare London; Kathryn A Lyons; Patricia B Bunting; Sylvia Volksdorf; Joseph L Duffy
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
The Journal of pharmacology and experimental therapeutics 2010;334(2):545-55.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2009;19(18):5334-8.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorganic & medicinal chemistry letters 2009;19(18):5329-33.
2008: Ge Dai; Rodolfo J Haedo; Vivien A Warren; Kevin S Ratliff; Randal M Bugianesi; Alison Rush; Mark E Williams; James Herrington; McHardy Smith; Owen B McManus; Andrew M Swensen
A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors.
Assay and drug development technologies 2008;6(2):195-212.
2008: Scott B Hoyt; Clare London; Matthew J Wyvratt; Michael H Fisher; Doreen E Cashen; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Bioorganic & medicinal chemistry letters 2008;18(6):1963-6.
2008: Clare London; Scott B Hoyt; William H Parsons; Brande S Williams; Vivien A Warren; Richard A Tschirret-Guth; McHardy Smith; Birgit T Priest; Erin McGowan; William J Martin; Kathryn A Lyons; Xiaohua Li; Bindhu V Karanam; Nina Jochnowitz; Maria L Garcia; John P Felix; Brian Dean; Catherine Abbadie; Gregory J Kaczorowski; Joseph L Duffy
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorganic & medicinal chemistry letters 2008;18(5):1696-701.
2007: Scott B Hoyt; Clare London; Hyun O Ok; Edward Gonzalez; Joseph L Duffy; Catherine Abbadie; Brian Dean; John P Felix; Maria L Garcia; Nina Jochnowitz; Bindhu V Karanam; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Richard A Tschirret-Guth; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(22):6172-7.
2007: Scott B Hoyt; Clare London; David J. Gorin; Matthew J Wyvratt; Michael H Fisher; Catherine Abbadie; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; Amy Ritter; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(16):4630-4.
2007: Birgit T Priest; Kenneth M Blumenthal; Jaime J Smith; Vivien A Warren; McHardy Smith
ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.
Toxicon : official journal of the International Society on Toxinology 2007;49(2):194-201.
2006: James Herrington; Yun-Ping Zhou; Randal M Bugianesi; Paula M Dulski; Yue Feng; Vivien A Warren; McHardy Smith; Martin G Kohler; Victor M Garsky; Manuel Sanchez; Michael Wagner; Kristin Raphaelli; Priya Banerjee; Chinweze Ahaghotu; Denise Wunderler; Birgit T Priest; John T Mehl; Maria L Garcia; Owen B McManus; Gregory J Kaczorowski; Robert S Slaughter
Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.
Diabetes 2006;55(4):1034-42.
2006: Dong Ok; Chunshi Li; Catherine Abbadie; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; William J Martin; Birgit T Priest; McHardy Smith; Brande S Williams; Matthew J Wyvratt; William H Parsons
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.
Bioorganic & medicinal chemistry letters 2006;16(5):1358-61.
2005: Jun Liang; Richard Brochu; charles cohen; Ivy E Dick; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; Peter T Meinke; Birgit T Priest; william Schmalhofer; McHardy Smith; Jason W Tarpley; Brande S Williams; William J Martin; William H Parsons
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(11):2943-7.
2005: Pengcheng P Shao; Dong Ok; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Chunshi Li; Kathryn A Lyons; William J Martin; Peter T Meinke; Birgit T Priest; McHardy Smith; Matthew J Wyvratt; Feng Ye; William H Parsons
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(7):1901-7.
2004: Sheo B Singh; John G Ondeyka; Hiranthi Jayasuriya; Deborah L Zink; Sookhee N Ha; Arlene M Dahl-Roshak; Joyce Greene; Jennifer A Kim; McHardy Smith; Wesley L Shoop; Jan Tkacz
Nodulisporic acids D-F: structure, biological activities, and biogenetic relationships.
Journal of natural products 2004;67(9):1496-506.
2004: Birgit T Priest; Maria L Garcia; Richard E Middleton; Richard Brochu; Samantha Clark; Ge Dai; Ivy E Dick; John P Felix; Chou J Liu; Brita S Reiseter; william Schmalhofer; Pengcheng P Shao; Yui S Tang; Margaret Z Chou; Martin G Kohler; McHardy Smith; Vivien A Warren; Brande S Williams; charles cohen; William J Martin; Peter T Meinke; William H Parsons; Keith A Wafford; Gregory J Kaczorowski
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Biochemistry 2004;43(30):9866-76.
2004: John P Felix; Brande S Williams; Birgit T Priest; Richard Brochu; Ivy E Dick; Vivien A Warren; Lizhen Yan; Robert S Slaughter; Gregory J Kaczorowski; McHardy Smith; Maria L Garcia
Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.
Assay and drug development technologies 2004;2(3):260-8.
2002: Richard E Middleton; Vivien A Warren; Richard L Kraus; Jeremy C Hwang; Chou J Liu; Ge Dai; Richard Brochu; Martin G Kohler; Ying-Duo Gao; Victor M Garsky; Michael J Bogusky; John T Mehl; charles cohen; McHardy Smith
Two tarantula peptides inhibit activation of multiple sodium channels.
Biochemistry 2002;41(50):14734-47.
2002: Peter T Meinke; McHardy Smith; Wesley L Shoop
Nodulisporic acid: its chemistry and biology.
Current topics in medicinal chemistry 2002;2(7):655-74.
2002: Steven W Ludmerer; Vivien A Warren; Brande S Williams; Yingcong Zheng; David C Hunt; Michelle B Ayer; Michael A Wallace; Ashok G Chaudhary; Marjorie A Egan; Peter T Meinke; Dennis C Dean; Maria L Garcia; Doris F Cully; McHardy Smith
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Biochemistry 2002;41(20):6548-60.
2000: N S Kane; B Hirschberg; S Qian; D Hunt; B Thomas; Richard Brochu; Steven W Ludmerer; Yingcong Zheng; McHardy Smith; JP Arena; charles cohen; Dennis M Schmatz; JW Warmke; Doris F Cully
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13949-54.
2000: McHardy Smith; Vivien A Warren; B S Thomas; Richard Brochu; E A Ertel; S Rohrer; J Schaeffer; Dennis M Schmatz; B R Petuch; Yui S Tang; Peter T Meinke; Gregory J Kaczorowski; charles cohen
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.
Biochemistry 2000;39(18):5543-54.
2000: JA Dent; McHardy Smith; D K Vassilatis; Leon Avery
The genetics of ivermectin resistance in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2674-9.
1999: siegmund wanner; Hartmut Glossmann; Hans-Günther Knaus; R Baker; William H Parsons; Kathleen M Rupprecht; Richard Brochu; charles cohen; william Schmalhofer; McHardy Smith; Vivien A Warren; Maria L Garcia; Gregory J Kaczorowski
WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels.
Biochemistry 1999;38(34):11137-46.
1995: Paula Q Barrett; E A Ertel; McHardy Smith; J J Nee; C J Cohen
Voltage-gated calcium currents have two opposing effects on the secretion of aldosterone.
The American journal of physiology 1995;268(4 Pt 1):C985-92.
1994: Hans-Günther Knaus; K Folander; M Garcia-Calvo; Maria L Garcia; Gregory J Kaczorowski; McHardy Smith; R Swanson
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.
The Journal of biological chemistry 1994;269(25):17274-8.
1994: E A Ertel; V A Warren; M E Adams; P R Griffin; C J Cohen; McHardy Smith
Type III omega-agatoxins: a family of probes for similar binding sites on L- and N-type calcium channels.
Biochemistry 1994;33(17):5098-108.
1994: E A Ertel; McHardy Smith; M D Leibowitz; C J Cohen
Isolation of myocardial L-type calcium channel gating currents with the spider toxin omega-Aga-IIIA.
The Journal of general physiology 1994;103(5):731-53.
1992: C J Cohen; E A Ertel; McHardy Smith; V J Venema; M E Adams; M D Leibowitz
High affinity block of myocardial L-type calcium channels by the spider toxin omega-Aga-toxin IIIA: advantages over 1,4-dihydropyridines.
Molecular pharmacology 1992;42(6):947-51.
1991: M Garcia-Calvo; J Vázquez; McHardy Smith; Gregory J Kaczorowski; Maria L Garcia
Characterization of the solubilized charybdotoxin receptor from bovine aortic smooth muscle.
Biochemistry 1991;30(46):11157-64.
1990: Paul Blount; McHardy Smith; J P Merlie
Assembly intermediates of the mouse muscle nicotinic acetylcholine receptor in stably transfected fibroblasts.
The Journal of cell biology 1990;111(6 Pt 1):2601-11.
1989: McHardy Smith; J P Merlie; J C Lawrence
Ca2+-dependent and cAMP-dependent control of nicotinic acetylcholine receptor phosphorylation in muscle cells.
The Journal of biological chemistry 1989;264(22):12813-9.
1987: McHardy Smith; J P Merlie; J C Lawrence
Regulation of phosphorylation of nicotinic acetylcholine receptors in mouse BC3H1 myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(18):6601-5.
1987: McHardy Smith; J Lindstrom; J P Merlie
Formation of the alpha-bungarotoxin binding site and assembly of the nicotinic acetylcholine receptor subunits occur in the endoplasmic reticulum.
The Journal of biological chemistry 1987;262(9):4367-76.
1986: McHardy Smith; S Schlesinger; J Lindstrom; J P Merlie
The effects of inhibiting oligosaccharide trimming by 1-deoxynojirimycin on the nicotinic acetylcholine receptor.
The Journal of biological chemistry 1986;261(31):14825-32.
1986: J P Merlie; McHardy Smith
Synthesis and assembly of acetylcholine receptor, a multisubunit membrane glycoprotein.
The Journal of membrane biology 1986;91(1):1-10.
1985: McHardy Smith; T Kendall Harden
Muscarinic cholinergic receptor-mediated attenuation of adenylate cyclase activity in rat heart membranes.
Journal of cyclic nucleotide and protein phosphorylation research 1985;10(2):197-210.
1985: T Kendall Harden; T Evans; J R Hepler; A R Hughes; M W Martin; Rick B Meeker; McHardy Smith; L I Tanner
Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors.
Advances in cyclic nucleotide and protein phosphorylation research 1985;19():207-20.
1984: T Evans; McHardy Smith; L I Tanner; T Kendall Harden
Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms.
Molecular pharmacology 1984;26(3):395-404.
1984: M W Martin; McHardy Smith; T Kendall Harden
Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart.
The Journal of pharmacology and experimental therapeutics 1984;230(2):424-30.
1984: P A Trimmer; T Evans; McHardy Smith; T Kendall Harden; Kenny Mccarthy
Combination of immunocytochemistry and radioligand receptor assay to identify beta-adrenergic receptor subtypes on astroglia in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(6):1598-606.
1984: McHardy Smith; T Kendall Harden
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
The Journal of pharmacology and experimental therapeutics 1984;228(2):425-33.
1982: T Kendall Harden; A G Scheer; McHardy Smith
Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).
Molecular pharmacology 1982;21(3):570-80.