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Hiroaki Sakurai

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Ji-Ye Kee; Isaya Hashimoto; Shozo Hojo; Yoshiko Igarashi; Tatsuro Irimura; Aya Ito; Takashi Nakayama; Ikuo Saiki; Hiroaki Sakurai; Naotoshi Shibahara; Kazuhiro Tsukada; Osamu Yoshie; Keiichi Koizumi
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.
Hiroaki Sakurai
Targeting of TAK1 in inflammatory disorders and cancer.
Yukihiro Furusawa; Peng Li; Takaharu Nomura; Ikuo Saiki; Hiroaki Sakurai; Yoshiaki Tabuchi; Zheng-Li Wei; Qing-Li Zhao; Takashi Kondo
TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.

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All Publications

2013: Ji-Ye Kee; Isaya Hashimoto; Shozo Hojo; Yoshiko Igarashi; Tatsuro Irimura; Aya Ito; Takashi Nakayama; Ikuo Saiki; Hiroaki Sakurai; Naotoshi Shibahara; Kazuhiro Tsukada; Osamu Yoshie; Keiichi Koizumi
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.
Oncology reports 2013;29(3):975-82.
2012: Hiroaki Sakurai
Targeting of TAK1 in inflammatory disorders and cancer.
Trends in pharmacological sciences 2012;33(10):522-30.
2012: Yukihiro Furusawa; Peng Li; Takaharu Nomura; Ikuo Saiki; Hiroaki Sakurai; Yoshiaki Tabuchi; Zheng-Li Wei; Qing-Li Zhao; Takashi Kondo
TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.
Radiation research 2012;177(6):766-74.
2012: Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Hirofumi Ogawa; Ikuo Saiki; Hiroaki Sakurai; Kazuyuki Tobe
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Oncology reports 2012;27(6):1726-32.
2012: Orawin Prangsaengtong; Ikuo Saiki; Hiroaki Sakurai; Kazutaka Senda; Naotoshi Shibahara; Yoshinori Doki; Michiko Jo; Jun Yeon Park; Keiichi Koizumi
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation.
Human cell 2012;25(2):36-44.
2012: Yasuhiro Igarashi; Takako Iida; Satoshi Miyanaga; Ikuo Saiki; Hiroaki Sakurai; Takao Fukuda; Koji Miyanouchi
Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.
The Journal of antibiotics 2012;65(4):207-9.
2012: Hiroki Inoue; Ikuo Saiki; Yutaka Shimada; Pornthip Waiwut; Hiroaki Sakurai
Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5.
International journal of oncology 2012;40(4):1058-65.
2012: Tatsuhiko Ozawa; Xiuhong Piao; Hiroaki Sakurai; Yue Zhou; Tsugunobu Andoh; Aishun Jin; Hiroyuki Kishi; Eiji Kobayashi; Atsushi Muraguchi
A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity.
PloS one 2012;7(12):e52383.
2012: Pornthip Waiwut; Satoru Yokoyama; Ikuo Saiki; Myoung-Sook Shin; Hiroaki Sakurai
Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.
Biological & pharmaceutical bulletin 2012;35(11):1997-2003.
2012: Pornthip Waiwut; Hiroki Inoue; Akiko Inujima; Ikuo Saiki; Hiroaki Sakurai
Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways.
International journal of oncology 2012;40(1):203-8.
2011: Oranuch Thanaketpaisarn; Pornthip Waiwut; Hiroaki Sakurai; Ikuo Saiki
Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.
International journal of oncology 2011;39(1):279-85.
2011: Alaa Refaat; Ikuo Saiki; Keiichi Koizumi; Shunsuke Suzuki; Yoshiaki Tabuchi; Ichiro Takasaki; Shoji Yamaoka; Yue Zhou; Hiroaki Sakurai
Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9.
The Journal of biological chemistry 2011;286(24):21092-9.
2011: Pornthip Waiwut; Myoung-Sook Shin; Akiko Inujima; Yue Zhou; Keiichi Koizumi; Ikuo Saiki; Hiroaki Sakurai
Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways.
Molecular and cellular biochemistry 2011;350(1-2):169-75.
2011: Yasunari Mizumoto; Satoru Kyo; Tohru Kiyono; Masahiro Takakura; Mitsuhiro Nakamura; Yoshiko Maida; Noriko Mori; Yukiko Bono; Hiroaki Sakurai; Masaki Inoue
Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1341-50.
2011: Orawin Prangsaengtong; Keiichi Koizumi; Kazutaka Senda; Hiroaki Sakurai; Ikuo Saiki
eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells.
Lymphatic research and biology 2011;9(1):53-9.
2011: Hiroshi Oka; Hirozo Goto; Keiichi Koizumi; Shin Nakamura; Koichi tsuneyama; Yue Zhou; Michiko Jo; Takako Fujimoto; Hiroaki Sakurai; Naotoshi Shibahara; Ikuo Saiki; Yutaka Shimada
Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():348686.
2010: Yasuhiro Igarashi; Linkai Yu; Satoshi Miyanaga; Takao Fukuda; Noriko Saitoh; Hiroaki Sakurai; Ikuo Saiki; Pablo Alonso-Vega; Martha E Trujillo
Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39.
Journal of natural products 2010;73(11):1943-6.
2010: Koji Sayama; Masahiro Yamamoto; Yuji Shirakata; Yasushi Hanakawa; Satoshi Hirakawa; Xiuju Dai; Mikiko Tohyama; Sho Tokumaru; Myoung-Sook Shin; Hiroaki Sakurai; Shizuo Akira; Koji Hashimoto
E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.
The Journal of biological chemistry 2010;285(39):30042-9.
2010: Yasuhiro Igarashi; Ryoko Shimasaki; Satoshi Miyanaga; Naoya Oku; Hiroyasu Onaka; Hiroaki Sakurai; Ikuo Saiki; Shigeru Kitani; Takuya Nihira; Waurawan Wimonsiravude; Watanalai Panbangred
Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.
The Journal of antibiotics 2010;63(9):563-5.
2010: Kriengsak Lirdprapamongkol; Hiroaki Sakurai; Shunsuke Suzuki; Keiichi Koizumi; Orawin Prangsaengtong; Amornrat Viriyaroj; Somsak Ruchirawat; Jisnuson Svasti; Ikuo Saiki
Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation.
In vivo (Athens, Greece) 2010;24(4):501-6.
2010: Shunsuke Suzuki; Yue Zhou; Alaa Refaat; Ichiro Takasaki; Keiichi Koizumi; Shoji Yamaoka; Yoshiaki Tabuchi; Ikuo Saiki; Hiroaki Sakurai
Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways.
The Journal of biological chemistry 2010;285(7):4441-6.
2010: Satoshi Miyanaga; Hiroaki Sakurai; Ikuo Saiki; Hiroyasu Onaka; Yasuhiro Igarashi
Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives.
Bioorganic & medicinal chemistry letters 2010;20(3):963-5.
2010: Shinichiro Kato; Keiichi Koizumi; Miyuki Yamada; Akiko Inujima; Nobuhiro Takeno; Tsuyoshi Nakanishi; Hiroaki Sakurai; Shinsaku Nakagawa; Ikuo Saiki
A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells.
Biological & pharmaceutical bulletin 2010;33(11):1878-85.
2009: Keiichi Koizumi; Yurika Saitoh; Takayuki Minami; Nobuhiro Takeno; Koichi tsuneyama; Tatsuro Miyahara; Takashi Nakayama; Hiroaki Sakurai; Yasuo Takano; Miyuki Nishimura; Toshio Imai; Osamu Yoshie; Ikuo Saiki
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7825-31.
2009: Syed Faisal Haider Zaidi; Takeshi Yamamoto; Alaa Refaat; Kanwal Ahmed; Hiroaki Sakurai; Ikuo Saiki; Takashi Kondo; Khan Usmanghani; Makoto Kadowaki; Toshiro Sugiyama
Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.
Helicobacter 2009;14(6):588-95.
2009: Miki Nishimura; Myoung-Sook Shin; Pattama Singhirunnusorn; Shunsuke Suzuki; Miho Kawanishi; Keiichi Koizumi; Ikuo Saiki; Hiroaki Sakurai
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Molecular and cellular biology 2009;29(20):5529-39.
2009: Seiji Cho; Keiichi Koizumi; Nobuhiro Takeno; Shinichiro Kato; Miyuki Yamada; Isaya Hashimoto; Hiroaki Sakurai; Kazuhiro Tsukada; Ikuo Saiki
Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice.
Molecular medicine reports 2009;2(5):773-7.
2009: Myoung-Sook Shin; Pattama Shinghirunnusorn; Yumiko Sugishima; Miki Nishimura; Shunsuke Suzuki; Keiichi Koizumi; Ikuo Saiki; Hiroaki Sakurai
Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1.
Biochimica et biophysica acta 2009;1793(7):1156-64.
2009: Yasuhiro Igarashi; Tsukasa Mogi; Saeko Yanase; Satoshi Miyanaga; Tsuyoshi Fujita; Hiroaki Sakurai; Ikuo Saiki; Ayumi Ohsaki
Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp.
Journal of natural products 2009;72(5):980-2.
2009: Yasumasa Minoda; Hiroaki Sakurai; Takashi Kobayashi; Akihiko Yoshimura; Giichi Takaesu
An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.
Biochemical and biophysical research communications 2009;381(3):412-7.
2009: Satoshi Miyanaga; Hiroaki Sakurai; Ikuo Saiki; Hiroyasu Onaka; Yasuhiro Igarashi
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
Bioorganic & medicinal chemistry 2009;17(7):2724-32.
2009: Satoshi Tsunoda; Hiroaki Sakurai; Yurika Saito; Yoko Ueno; Keiichi Koizumi; Ikuo Saiki
Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability.
The American journal of pathology 2009;174(2):671-83.
2009: Naparat Kammasud; Chantana Boonyarat; Kingkan Sanphanya; Maleeruk Utsintong; Satoshi Tsunoda; Hiroaki Sakurai; Ikuo Saiki; Isabelle André; David S Grierson; Opa Vajragupta
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
Bioorganic & medicinal chemistry letters 2009;19(3):745-50.
2009: Kazutaka Senda; Keiichi Koizumi; Orawin Prangsaengtong; Takayuki Minami; Shunsuke Suzuki; Ichiro Takasaki; Yoshiaki Tabuchi; Hiroaki Sakurai; Yoshinori Doki; Takuro Misaki; Ikuo Saiki
Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity.
Lymphatic research and biology 2009;7(2):69-74.
2009: Fortunatus Sunghwa; Hiroaki Sakurai; Ikuo Saiki; Mamoru Koketsu
Iodine-catalyzed etherification of morroniside.
Chemical & pharmaceutical bulletin 2009;57(1):112-5.
2008: Chinami Matsumoto; Tetsuko Kojima; Kazuo Ogawa; Satoshi Kamegai; Takuya Oyama; Yukari Shibagaki; Tetsuo Kawasaki; Hiroshi Fujinaga; Kozo Takahashi; Hiroaki Hikiami; Hirozo Goto; Chizuru Kiga; Keiichi Koizumi; Hiroaki Sakurai; Hiroshi Muramoto; Yutaka Shimada; Masahiro Yamamoto; Katsutoshi Terasawa; Shuichi Takeda; Ikuo Saiki
A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine.
Evidence-based complementary and alternative medicine : eCAM 2008;5(4):463-74.
2008: Chizuru Kiga; Hiroaki Sakurai; Hirozo Goto; Kazuko Hayashi; Yutaka Shimada; Ikuo Saiki
Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats.
Life sciences 2008;83(17-18):625-31.
2008: Yoko Ueno; Hiroaki Sakurai; Satoshi Tsunoda; Min-Kyung Choo; Mitsuhiro Matsuo; Keiichi Koizumi; Ikuo Saiki
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.
International journal of cancer. Journal international du cancer 2008;123(2):340-7.
2008: Hiroshi Kamiyama; Takeo Usui; Hiroaki Sakurai; Mitsuru Shoji; Yujiro Hayashi; Hideaki Kakeya; Hiroyuki Osada
Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.
Bioscience, biotechnology, and biochemistry 2008;72(7):1894-900.
2008: Isaya Hashimoto; Keiichi Koizumi; Mikiko Tatematsu; Takayuki Minami; Seiji Cho; Nobuhiro Takeno; Akitoshi Nakashima; Hiroaki Sakurai; Shigeru Saito; Kazuhiro Tsukada; Ikuo Saiki
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells.
European journal of cancer (Oxford, England : 1990) 2008;44(7):1022-9.
2008: Min-Kyung Choo; Hiroaki Sakurai; Dong-Hyun Kim; Ikuo Saiki
A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells.
Oncology reports 2008;19(3):595-600.
2007: Yurika Saitoh; Keiichi Koizumi; Hiroaki Sakurai; Takayuki Minami; Ikuo Saiki
RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells.
Biochemical and biophysical research communications 2007;364(3):417-22.
2007: Kazuo Ogawa; Tetsuko Kojima; Chinami Matsumoto; Satoshi Kamegai; Takuya Oyama; Yukari Shibagaki; Hiroshi Muramoto; Tetsuo Kawasaki; Hiroshi Fujinaga; Kozo Takahashi; Hiroaki Hikiami; Hirozo Goto; Chizuru Kiga; Keiichi Koizumi; Hiroaki Sakurai; Yutaka Shimada; Masahiro Yamamoto; Katsutoshi Terasawa; Shuichi Takeda; Ikuo Saiki
Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients.
Clinical biochemistry 2007;40(15):1113-21.
2007: Hiroaki Sakurai
[New insights into physiological functions of the kinase TAK1].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(9):883-7.
2007: Naparat Kammasud; Chantana Boonyarat; Satoshi Tsunoda; Hiroaki Sakurai; Ikuo Saiki; David S Grierson; Opa Vajragupta
Novel inhibitor for fibroblast growth factor receptor tyrosine kinase.
Bioorganic & medicinal chemistry letters 2007;17(17):4812-8.
2007: Shunsuke Suzuki; Pattama Singhirunnusorn; Akinori Mori; Shoji Yamaoka; Isao Kitajima; Ikuo Saiki; Hiroaki Sakurai
Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB.
The Journal of biological chemistry 2007;282(35):25177-81.
2007: Mitsuhiro Matsuo; Sanae Yamada; Keiichi Koizumi; Hiroaki Sakurai; Ikuo Saiki
Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.
European journal of cancer (Oxford, England : 1990) 2007;43(11):1748-54.
2007: Yasuhiro Igarashi; Martha E Trujillo; Eustoquio Martínez-Molina; Saeko Yanase; Satoshi Miyanaga; Takamasa Obata; Hiroaki Sakurai; Ikuo Saiki; Tsuyoshi Fujita; Tamotsu Furumai
Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.
Bioorganic & medicinal chemistry letters 2007;17(13):3702-5.
2007: Mitsuhiro Matsuo; Hiroaki Sakurai; Keiichi Koizumi; Ikuo Saiki
Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.
Cancer letters 2007;251(2):288-95.
2007: Keiichi Koizumi; Yoko Kozawa; Yasukata Ohashi; Eliane Shizuka Nakamura; Yasushi Aozuka; Hiroaki Sakurai; Katsuyuki Ichiki; Yoshinori Doki; Takuro Misaki; Ikuo Saiki
CCL21 promotes the migration and adhesion of highly lymph node metastatic human non-small cell lung cancer Lu-99 in vitro.
Oncology reports 2007;17(6):1511-6.
2007: Shozo Hojo; Keiichi Koizumi; Koichi tsuneyama; Yoshihisa Arita; Zhengguo Cui; Kanna Shinohara; Takayuki Minami; Isaya Hashimoto; Takashi Nakayama; Hiroaki Sakurai; Yasuo Takano; Osamu Yoshie; Kazuhiro Tsukada; Ikuo Saiki
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer.
Cancer research 2007;67(10):4725-31.
2007: Pattama Singhirunnusorn; Yoko Ueno; Mitsuhiro Matsuo; Shunsuke Suzuki; Ikuo Saiki; Hiroaki Sakurai
Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway.
The Journal of biological chemistry 2007;282(17):12698-706.
2007: Prashant B Shambharkar; Marzenna Blonska; Bhanu P Pappu; Hongxiu Li; Yun You; Hiroaki Sakurai; Bryant G Darnay; Hiromitsu Hara; Josef M Penninger; Xin Lin
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
The EMBO journal 2007;26(7):1794-805.
2007: Satoshi Tsunoda; Toshiyuki Nakamura; Hiroaki Sakurai; Ikuo Saiki
Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization.
Cancer science 2007;98(4):541-8.
2007: Juthamas Chuethong; Kohei Oda; Hiroaki Sakurai; Ikuo Saiki; Wichet Leelamanit
Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis.
Biological & pharmaceutical bulletin 2007;30(3):428-32.
2006: Akinori Mori; Hiroaki Sakurai; Min-Kyung Choo; Ryosuke Obi; Keiichi Koizumi; Chiho Yoshida; Yutaka Shimada; Ikuo Saiki
Severe pulmonary metastasis in obese and diabetic mice.
International journal of cancer. Journal international du cancer 2006;119(12):2760-7.
2006: Min-Kyung Choo; Noritaka Kawasaki; Pattama Singhirunnusorn; Keiichi Koizumi; Shintaro Sato; Shizuo Akira; Ikuo Saiki; Hiroaki Sakurai
Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Molecular cancer therapeutics 2006;5(12):2970-6.
2006: Masahiro Yamamoto; Shintaro Sato; Tatsuya Saitoh; Hiroaki Sakurai; Satoshi Uematsu; Taro Kawai; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7520-4.
2006: Satoshi Miyanaga; Takamasa Obata; Hiroyasu Onaka; Tsuyoshi Fujita; Noriko Saito; Hiroaki Sakurai; Ikuo Saiki; Tamotsu Furumai; Yasuhiro Igarashi
Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.
The Journal of antibiotics 2006;59(11):698-703.
2006: Masahiro Yamamoto; Toru Okamoto; Kiyoshi Takeda; Shintaro Sato; Hideki Sanjo; Satoshi Uematsu; Tatsuya Saitoh; Naoki Yamamoto; Hiroaki Sakurai; Ken J Ishii; Shoji Yamaoka; Taro Kawai; Yoshiharu Matsuura; Osamu Takeuchi; Shizuo Akira
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nature immunology 2006;7(9):962-70.
2006: Axel Thiefes; Alexander Wolf; Anneke Doerrie; Guntram A Grassl; Kunihiro Matsumoto; Ingo B Autenrieth; Erwin Bohn; Hiroaki Sakurai; Rainer Niedenthal; Klaus Resch; Michael Kracht
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
EMBO reports 2006;7(8):838-44.
2006: Min-Kyung Choo; Hiroaki Sakurai; Keiichi Koizumi; Ikuo Saiki
TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.
International journal of cancer. Journal international du cancer 2006;118(11):2758-64.
2006: Shunsuke Suzuki; Pattama Singhirunnusorn; Hiroyasu Nakano; Takahiro Doi; Ikuo Saiki; Hiroaki Sakurai
Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.
FEBS letters 2006;580(13):3257-62.
2006: Hirofumi Ogawa; Tomoharu Gomi; Mikio Nishizawa; Yumiko Hayakawa; Shunro Endo; Kyoko Hayashi; Hiroshi Ochiai; Fusao Takusagawa; Henry C Pitot; Hisashi Mori; Hiroaki Sakurai; Keiichi Koizumi; Ikuo Saiki; Hirofumi Oda; Takashi Fujishita; Toshiro Miwa; Muneharu Maruyama; Masashi Kobayashi
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Biochimica et biophysica acta 2006;1764(5):961-71.
2006: Yurika Saitoh; Keiichi Koizumi; Takayuki Minami; Keiko Sekine; Hiroaki Sakurai; Ikuo Saiki
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Biological & pharmaceutical bulletin 2006;29(4):709-12.
2006: Soo Jin Lee; Hiroaki Sakurai; Keiichi Koizumi; Gyu-Yong Song; Yong Soo Bae; Hyung-Min Kim; Kyung-Sun Kang; Young-Joon Surh; Ikuo Saiki; Sung Hoon Kim
MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells.
Cancer letters 2006;233(1):57-67.
2006: Kazuo Yasumoto; Keiichi Koizumi; Atsuhiro Kawashima; Yurika Saitoh; Yoshihisa Arita; Kanna Shinohara; Takayuki Minami; Takashi Nakayama; Hiroaki Sakurai; Yutaka Takahashi; Osamu Yoshie; Ikuo Saiki
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Cancer research 2006;66(4):2181-7.
2006: Mitsuhiro Matsuo; Hiroaki Sakurai; Yoko Ueno; Osamu Ohtani; Ikuo Saiki
Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib.
Cancer science 2006;97(2):155-62.
2006: Eliane Shizuka Nakamura; Keiichi Koizumi; Mitsuo Kobayashi; Yurika Saitoh; Yoshihisa Arita; Takashi Nakayama; Hiroaki Sakurai; Osamu Yoshie; Ikuo Saiki
RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4.
Clinical & experimental metastasis 2006;23(1):9-18.
2005: Marzenna Blonska; Prashant B Shambharkar; Masayuki Kobayashi; Dongyu Zhang; Hiroaki Sakurai; Bing Su; Xin Lin
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
The Journal of biological chemistry 2005;280(52):43056-63.
2005: Min-Kyung Choo; Hiroaki Sakurai; Keiichi Koizumi; Ikuo Saiki
Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway.
Cancer letters 2005;230(1):47-56.
2005: Hiroaki Sakurai; Pattama Singhirunnusorn; Emi Shimotabira; Atsushi Chino; Shunsuke Suzuki; Keiichi Koizumi; Ikuo Saiki
TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
FEBS letters 2005;579(29):6641-6.
2005: Hisaaki Shinohara; Tomoharu Yasuda; Yuichi Aiba; Hideki Sanjo; Megumi Hamadate; Hiroshi Watarai; Hiroaki Sakurai; Tomohiro Kurosaki
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
The Journal of experimental medicine 2005;202(10):1423-31.
2005: Eiji Tega; Chizuru Kiga; Atsushi Chino; Hiroaki Sakurai; Keiichi Koizumi; Tadato Tani; Ikuo Saiki
A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes.
Biological & pharmaceutical bulletin 2005;28(10):1869-72.
2005: Robert F Schwabe; Hiroaki Sakurai
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1758-60.
2005: Chizuru Kiga; Takako Nakagawa; Keiichi Koizumi; Hiroaki Sakurai; Yukari Shibagaki; Kazuo Ogawa; Hirozo Goto; Ikuo Saiki
Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform.
Biological & pharmaceutical bulletin 2005;28(6):1031-7.
2005: Y Ueno; Hiroaki Sakurai; M Matsuo; M K Choo; K Koizumi; Ikuo Saiki
Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib.
British journal of cancer 2005;92(9):1690-5.
2005: Kriengsak Lirdprapamongkol; Hiroaki Sakurai; Noritaka Kawasaki; Min-Kyung Choo; Yurika Saitoh; Yasushi Aozuka; Pattama Singhirunnusorn; Somsak Ruchirawat; Jisnuson Svasti; Ikuo Saiki
Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(1):57-65.
2005: Atsushi Chino; Hiroaki Sakurai; Min-Kyung Choo; Keiichi Koizumi; Yutaka Shimada; Katsutoshi Terasawa; Ikuo Saiki
Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages.
International immunopharmacology 2005;5(5):871-82.
2005: Isaku Yoshioka; Yasunori Tsuchiya; Yasushi Aozuka; Yasuharu Onishi; Hiroaki Sakurai; Keiichi Koizumi; Kazuhiro Tsukada; Ikuo Saiki
Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells.
Anticancer research 2005;25(2A):815-20.
2005: Pattama Singhirunnusorn; Shunsuke Suzuki; Noritaka Kawasaki; Ikuo Saiki; Hiroaki Sakurai
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.
The Journal of biological chemistry 2005;280(8):7359-68.
2004: Yasushi Aozuka; Keiichi Koizumi; Yurika Saitoh; Yasuji Ueda; Hiroaki Sakurai; Ikuo Saiki
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Cancer letters 2004;216(1):35-42.
2004: Jing Hu; Hiroyasu Nakano; Hiroaki Sakurai; Nancy H Colburn
Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells.
Carcinogenesis 2004;25(10):1991-2003.
2004: Takami Majima; Tomohiro Yamada; Eiji Tega; Hiroaki Sakurai; Ikuo Saiki; Tadato Tani
Pharmaceutical evaluation of liquorice before and after roasting in mice.
The Journal of pharmacy and pharmacology 2004;56(5):589-95.
2003: Fumitaka Fujita; Yuko Taniguchi; Takashi Kato; Yasuko Narita; Akiko Furuya; Tatsuhiro Ogawa; Hiroaki Sakurai; Takashi Joh; Makoto Itoh; Mireille Delhase; Michael Karin; Makoto Nakanishi
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
Molecular and cellular biology 2003;23(21):7780-93.
2003: Hiroaki Sakurai; Shunsuke Suzuki; Noritaka Kawasaki; Hiroyasu Nakano; Tatsuma Okazaki; Atsushi Chino; Takahiro Doi; Ikuo Saiki
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
The Journal of biological chemistry 2003;278(38):36916-23.
2003: Soo Jin Lee; Yasukata Ohashi; Hiroaki Sakurai; Ikuo Saiki
TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
Cancer letters 2003;198(2):169-77.
2003: S J Lee; Hiroaki Sakurai; K Oshima; S H Kim; Ikuo Saiki
Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b.
European journal of cancer (Oxford, England : 1990) 2003;39(11):1632-41.
2003: Mitsuhiro Matsuo; Hiroaki Sakurai; Ikuo Saiki
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model.
Molecular cancer therapeutics 2003;2(6):557-61.
2003: Yukari Kanzaki; Fumikazu Onoue; Hiroaki Sakurai; Toshinori Ide
Telomerase upregulates expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor in normal human fibroblasts.
Biochemical and biophysical research communications 2003;305(1):150-4.
2003: Tatsuma Okazaki; Sachiko Sakon; Tomonari Sasazuki; Hiroaki Sakurai; Takahiro Doi; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses.
Biochemical and biophysical research communications 2003;300(4):807-12.
2003: Yasukata Ohashi; Yasunori Tsuchiya; Keiichi Koizumi; Hiroaki Sakurai; Ikuo Saiki
Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model.
Oncology 2003;65(3):250-8.
2002: Hiroaki Sakurai; Akito Nishi; Naoya Sato; Junko Mizukami; Hidetaka Miyoshi; Takahisa Sugita
TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.
Biochemical and biophysical research communications 2002;297(5):1277-81.
2002: Nywana Sizemore; Natalia Lerner; Nicole Dombrowski; Hiroaki Sakurai; George R Stark
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
The Journal of biological chemistry 2002;277(6):3863-9.
2002: Junko Mizukami; Giichi Takaesu; Hiroyuki Akatsuka; Hiroaki Sakurai; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Naoki Sakurai
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.
Molecular and cellular biology 2002;22(4):992-1000.
2001: J Yang; Guo-Huang Fan; Brian E Wadzinski; Hiroaki Sakurai; Ann Richmond
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
The Journal of biological chemistry 2001;276(51):47828-33.
2000: C E Dempsey; Hiroaki Sakurai; T Sugita; François Guesdon
Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.
Biochimica et biophysica acta 2000;1517(1):46-52.
2000: Hiroaki Sakurai; Hidetaka Miyoshi; Junko Mizukami; Takahisa Sugita
Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.
FEBS letters 2000;474(2-3):141-5.
2000: Y Hisada; Hiroaki Sakurai; takeshi sugaya
Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation.
Biochemical and biophysical research communications 2000;269(2):309-16.
1999: Hiroaki Sakurai; H Chiba; Hidetaka Miyoshi; Takahisa Sugita; Wataru Toriumi
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
The Journal of biological chemistry 1999;274(43):30353-6.
1999: Hiroaki Sakurai; Hidetaka Miyoshi; Wataru Toriumi; Takahisa Sugita
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.
The Journal of biological chemistry 1999;274(15):10641-8.
1999: Y Hisada; takeshi sugaya; M Yamanouchi; H Uchida; H Fujimura; Hiroaki Sakurai; A Fukamizu; K Murakami
Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice.
The Journal of clinical investigation 1999;103(5):627-35.
1998: Hiroaki Sakurai; T Sugita
c-Jun N-terminal kinase-mediated AP-1 activation in experimental glomerulonephritis in rats.
Biochemistry and molecular biology international 1998;45(4):831-9.
1998: Hiroaki Sakurai; N Shigemori; K Hasegawa; T Sugita
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
Biochemical and biophysical research communications 1998;243(2):545-9.
1997: Hiroaki Sakurai; N Shigemori; Y Hisada; T Ishizuka; K Kawashima; T Sugita
Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action.
Biochimica et biophysica acta 1997;1362(2-3):252-62.
1997: S Tanaka; Hiroaki Sakurai; M Sugiura; K Kawashima; T Sugita
Domon L, an immunopotentiating agent, acts as an NF-kappaB activator.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1997;59(7):575-9.
1996: A Tabuchi; ESTHER OH; A Taoka; Hiroaki Sakurai; Tomofusa Tsuchiya; M Tsuda
Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death.
The Journal of biological chemistry 1996;271(49):31061-7.
1996: Hiroaki Sakurai; Y Hisada; M Ueno; M Sugiura; K Kawashima; T Sugita
Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats.
Biochimica et biophysica acta 1996;1316(2):132-8.
1995: K Ohtani; Hiroaki Sakurai; ESTHER OH; E Iwata; Tomofusa Tsuchiya; M Tsuda
Involvement of protein kinase C in Ca(2+)-signaling pathways to activation of AP-1 DNA-binding activity evoked via NMDA- and voltage-gated Ca2+ channels.
Journal of neurochemistry 1995;65(2):605-14.
1993: N Katayama; E Iwata; Hiroaki Sakurai; Tomofusa Tsuchiya; M Tsuda
Additive induction of Egr-1 (zif/268) mRNA expression in neuroblastoma x glioma hybrid NG108-15 cells via cholinergic muscarinic, alpha 2-adrenergic, and bradykinin receptors.
Journal of neurochemistry 1993;60(3):902-7.
1992: Hiroaki Sakurai; R Kurusu; K Sano; Tomofusa Tsuchiya; M Tsuda
Stimulation of cultured cerebellar granule cells via glutamate receptors induces TRE- and CRE-binding activities mediated by common DNA-binding complexes.
Journal of neurochemistry 1992;59(6):2067-75.
1991: Hiroaki Sakurai; K Kikuchi; T Tsuchiya; H Kanazawa; M Tsuda
Developmentally and regionally regulated alterations of octamer- and GC-box-binding activities during the postnatal development of mouse cerebellum.
Brain research. Developmental brain research 1991;61(2):161-8.