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Imre Kovesdi

Research Profile

Living Beings

Chemicals & Drugs

Devices

Gene Transfer Techniques

Procedures

Genetic Therapy

Anatomy

Genes & Molecular Sequences

Transgenes

Physiology

Transduction, Genetic

Co-author Network

Publications

TOP 3
Briana Jill Williams; Alexander V Pereboev; Donna L Rogers; Lisa K Adams; Shilpa Bhatia; Susan Boling; Jennifer L Carroll; David T Curiel; Nikolay Korokhov; Imre Kovesdi; Xiao-Lin Li; J Michael Mathis
Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector.
Chitra Upadhyay; Arun Ammayappan; Deendayal Patel; Imre Kovesdi; Vikram N Vakharia
Recombinant infectious bursal disease virus carrying hepatitis C virus epitopes.
J Michael Mathis; Shilpa Bhatia; Alok Khandelwal; Imre Kovesdi; Stephen J Lokitz; Yoshi Odaka; Amol M Takalkar; Tracee Terry; David T Curiel
Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging.

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All Publications

2012: Briana Jill Williams; Alexander V Pereboev; Donna L Rogers; Lisa K Adams; Shilpa Bhatia; Susan Boling; Jennifer L Carroll; David T Curiel; Nikolay Korokhov; Imre Kovesdi; Xiao-Lin Li; J Michael Mathis
Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector.
PloS one 2012;7(10):e46981.
2011: Chitra Upadhyay; Arun Ammayappan; Deendayal Patel; Imre Kovesdi; Vikram N Vakharia
Recombinant infectious bursal disease virus carrying hepatitis C virus epitopes.
Journal of virology 2011;85(3):1408-14.
2011: J Michael Mathis; Shilpa Bhatia; Alok Khandelwal; Imre Kovesdi; Stephen J Lokitz; Yoshi Odaka; Amol M Takalkar; Tracee Terry; David T Curiel
Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging.
PloS one 2011;6(2):e16792.
2010: Imre Kovesdi; Susan J Hedley
Adenoviral producer cells.
Viruses 2010;2(8):1681-703.
2008: Ping Chen; Jie Tian; Imre Kovesdi; Joseph T Bruder
Promoters influence the kinetics of transgene expression following adenovector gene delivery.
The journal of gene medicine 2008;10(2):123-31.
2007: Jason G D Gall; Alena Lizonova; Damodar Ettyreddy; Duncan McVey; Mohammed Zuber; Imre Kovesdi; Barbara Aughtman; C Richter King; Douglas E Brough
Rescue and production of vaccine and therapeutic adenovirus vectors expressing inhibitory transgenes.
Molecular biotechnology 2007;35(3):263-73.
2006: Susan J Hedley; Jian Chen; John D Mountz; Jing Li; David T Curiel; Nikolay Korokhov; Imre Kovesdi
Targeted and shielded adenovectors for cancer therapy.
Cancer immunology, immunotherapy : CII 2006;55(11):1412-9.
2006: Anja Krause; Ju H Joh; Neil R Hackett; Peter W Roelvink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein; Stefan Worgall
Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity.
Journal of virology 2006;80(11):5523-30.
2005: Stefan Worgall; Anja Krause; Michael Rivara; Kyung-Kim Hee; Enrico V Vintayen; Neil R Hackett; Peter W Roelvink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.
The Journal of clinical investigation 2005;115(5):1281-9.
2004: Rossella Rota; Teresa Riccioni; Marco Zaccarini; Stefania Lamartina; Anna Del Gallo; Angelo Fusco; Imre Kovesdi; Emilio Balestrazzi; Damiano C Abeni; Robin R Ali; Maurizio C Capogrossi
Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer.
The journal of gene medicine 2004;6(9):992-1002.
2004: Baohong Cao; J Bruder; Imre Kovesdi; Johnny Huard
Muscle stem cells can act as antigen-presenting cells: implication for gene therapy.
Gene therapy 2004;11(17):1321-30.
2004: He Wang; Joan A Keiser; Bronia Olszewski; Wendy Rosebury; Andrew Robertson; Imre Kovesdi; David F Gordon
Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF.
International journal of molecular medicine 2004;13(4):581-7.
2004: corrado cirielli; Francesco Serino; Stefania Straino; Gabriele Toietta; Damiano Abeni; Giorgio Ventoruzzo; Giuseppe Orlando; Paola Mazzanti; Guido Melillo; Thomas J Whickham; Imre Kovesdi; Paolo Biglioli; carlo gaetano; Maurizio C Capogrossi
Adenovirus vectors targeting alphaV integrin or heparan sulfate receptors display different distribution of transgene activity after intramuscular injection.
The journal of gene medicine 2004;6(3):309-16.
2004: L A Perrin; J E June; Wendy Rosebury; Andrew Robertson; Imre Kovesdi; J T Bruder; P D Kessler; Joan A Keiser; David F Gordon
Increased revascularization efficacy after administration of an adenovirus encoding VEGF(121).
Gene therapy 2004;11(6):512-21.
2004: Stefan Worgall; Annette Busch; Michael Rivara; David Bonnyay; Philip L Leopold; Robert Merritt; Neil R Hackett; Peter W Rovelink; Joseph T Bruder; Thomas J Wickham; Imre Kovesdi; Helen-Ann Brown Epstein
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Journal of virology 2004;78(5):2572-80.
2004: Zifa Wang; Tracy Cook; Sean Alber; Kaihong Liu; Imre Kovesdi; simon simon watkins; Yoram Vodovotz; Timothy R Billiar; David Blumberg
Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity.
Cancer research 2004;64(4):1386-95.
2004: Sean O Hynes; Leslie A Smith; Darcy M Richardson; Imre Kovesdi; Timothy O'Brien; Zvonimir S Katusic
In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery.
American journal of physiology. Heart and circulatory physiology 2004;286(2):H570-4.
2003: Duncan McVey; Mohammed Zuber; Douglas E Brough; Imre Kovesdi
Adenovirus vector library: an approach to the discovery of gene and protein function.
The Journal of general virology 2003;84(Pt 12):3417-22.
2003: Jie-Sheng Zheng; Xiang-Qun Yang; Keith J Lookingland; Gregory D Fink; Christian Hesslinger; Gregory Kapatos; Imre Kovesdi; Alex F Chen
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
Circulation 2003;108(10):1238-45.
2003: Kai Wang; Paul D Kessler; Zhongmin Zhou; Marc S Penn; Farhad Forudi; Xiaorong Zhou; Khaldoun Tarakji; Melina R Kibbe; Imre Kovesdi; Douglas E Brough; Eric J Topol; A Michael Lincoff
Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(5 Pt 1):597-603.
2003: Michela Zanetti; Livius V d'Uscio; Imre Kovesdi; Zvonimir S Katusic; Timothy O'Brien
In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits.
Stroke; a journal of cerebral circulation 2003;34(5):1293-8.
2003: Melina R Kibbe; Christopher Johnnides; Susan Gleixner; Imre Kovesdi; Alena Lizonova; Brian Zuckerbraun; Timothy R Billiar; Edith Tzeng; Satish C Muluk
Regulation of tissue factor expression in smooth muscle cells with nitric oxide.
Journal of vascular surgery 2003;37(3):650-9.
2003: X Nan; Bo Peng; T-W Hahn; Ersell Richardson; Alena Lizonova; Imre Kovesdi; Marjorie Robert-Guroff
Development of an Ad7 cosmid system and generation of an Ad7deltaE1deltaE3HIV(MN) env/rev recombinant virus.
Gene therapy 2003;10(4):326-36.
2003: Peter L Gehlbach; Anna Maria Demetriades; Satoru Yamamoto; Tye Deering; Wei-Hong Xiao; Elia J Duh; Hoseong S Yang; Hong Lai; Imre Kovesdi; Miguel Carrion; Lisa Wei; Peter A Campochiaro
Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier.
Human gene therapy 2003;14(2):129-41.
2002: Daihiko Eguchi; Livius V d'Uscio; Chris Wambi; Deborah Weiler; Imre Kovesdi; Timothy O'Brien; Zvonimir S Katusic
Inhibitory effect of recombinant iNOS gene expression on vasomotor function of canine basilar artery.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2560-6.
2002: Hartmut Kuhn; Uta Liebers; Christian Gessner; Axel Schumacher; Christian Witt; Joachim Schauer; Imre Kovesdi; Gerhard Wolff
Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;20(3):703-9.
2002: Harris Perlman; Hongtao Liu; Constantinos Georganas; James M Woods; M Asif Amin; Alisa E Koch; Thomas Wickham; Imre Kovesdi; Toshiaki Mano; Kenneth Walsh; Richard M Pope
Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression.
The Journal of rheumatology 2002;29(8):1593-600.
2002: Masahiko Akiyama; Daihiko Eguchi; Deborah Weiler; Timothy O'Brien; Imre Kovesdi; Ramona S Scotland; William C Sessa; Zvonimir S Katusic
Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries.
Stroke; a journal of cerebral circulation 2002;33(4):1071-6.
2002: Duncan McVey; Mohammed Zuber; Damodar Ettyreddy; Douglas E Brough; Imre Kovesdi
Rapid construction of adenoviral vectors by lambda phage genetics.
Journal of virology 2002;76(8):3670-7.
2002: Melina R Kibbe; Jianrong Li; Suhua Nie; Byung Min Choi; Imre Kovesdi; Alena Lizonova; Timothy R Billiar; Edith Tzeng
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.
American journal of physiology. Cell physiology 2002;282(3):C625-34.
2001: David A Einfeld; R Schroeder; Peter W Roelvink; Alena Lizonova; C Richter King; Imre Kovesdi; Thomas J Wickham
Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions.
Journal of virology 2001;75(23):11284-91.
2001: Ian Kirby; R Lord; E Davison; Thomas J Wickham; Peter W Roelvink; Imre Kovesdi; Brian J Sutton; George Santis
Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes.
Journal of virology 2001;75(15):7210-4.
2001: Chooi-May Lai; Meliha Brankov; Tammy Zaknich; Yvonne K Y Lai; Wei-Yong Shen; Ian J Constable; Imre Kovesdi; P Elizabeth Rakoczy
Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization.
Human gene therapy 2001;12(10):1299-310.
2001: Melina R Kibbe; Edith Tzeng; Susan Gleixner; simon simon watkins; Imre Kovesdi; Alena Lizonova; Michel S Makaroun; Timothy R Billiar; Robert Y Rhee
Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia.
Journal of vascular surgery 2001;34(1):156-65.
2001: Jikui Shen; Neil Taylor; Linda Duncan; Imre Kovesdi; J T Bruder; John V Forrester; Andrew D Dick
Ex vivo adenovirus mediated gene transfection of human conjunctival epithelium.
The British journal of ophthalmology 2001;85(7):861-7.
2001: Baohong Cao; Ryan Pruchnic; Makoto Ikezawa; Xiao Xiao; J Li; T J Wickham; Imre Kovesdi; W A Rudert; Johnny Huard
The role of receptors in the maturation-dependent adenoviral transduction of myofibers.
Gene therapy 2001;8(8):627-37.
2001: William E Hobbs; D E Brough; Imre Kovesdi; Neal A DeLuca
Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival.
Journal of virology 2001;75(7):3391-403.
2001: Yongjun Tan; Robert H Costa; Imre Kovesdi; R R Reichel
Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage.
Gene expression 2001;9(6):237-48.
2000: He Wang; David F Gordon; Bronia Olszewski; Y L Song; Imre Kovesdi; Joan A Keiser
Rat sponge implant model: a new system for evaluating angiogenic gene transfer.
International journal of molecular medicine 2000;6(6):645-53.
2000: T Kurihara; D E Brough; Imre Kovesdi; Donald Kufe
Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.
The Journal of clinical investigation 2000;106(6):763-71.
2000: L H Gowdak; L Poliakova; X Wang; Imre Kovesdi; Kenneth W Fishbein; Antonella Zacheo; Roberta Palumbo; Stefania Straino; Costanza Emanueli; M Marrocco-Trischitta; Edward G Lakatta; Piero Anversa; RICHARD SPENCER; Mark I Talan; Maurizio C Capogrossi
Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia.
Circulation 2000;102(5):565-71.
2000: F C Marini; Q Yu; T Wickham; Imre Kovesdi; M Andreeff
Adenovirus as a gene therapy vector for hematopoietic cells.
Cancer gene therapy 2000;7(6):816-25.
2000: Melina R Kibbe; Juan Li; Suhua Nie; simon simon watkins; Alena Lizonova; Imre Kovesdi; Richard L Simmons; Timothy R Billiar; Edith Tzeng
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.
Journal of vascular surgery 2000;31(6):1214-28.
2000: Q Yao; Joseph C Glorioso; C H Evans; Paul D Robbins; Imre Kovesdi; Thomas J Oligino; Steven C Ghivizzani
Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining.
The journal of gene medicine 2000;2(3):210-9.
2000: P Chen; Imre Kovesdi; J T Bruder
Effective repeat administration with adenovirus vectors to the muscle.
Gene therapy 2000;7(7):587-95.
2000: PC Lee; Z L Wang; Shiguang Qian; simon simon watkins; Alena Lizonova; Imre Kovesdi; Edith Tzeng; Richard L Simmons; Timothy R Billiar; Lawrence Shears
Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis.
Transplantation 2000;69(6):1186-92.
2000: Ran Kornowski; Martin B Leon; Shmuel Fuchs; Yoram Vodovotz; MA Flynn; David F Gordon; A Pierre; Imre Kovesdi; J A Keiser; Stephen E Epstein
Electromagnetic guidance for catheter-based transendocardial injection: a platform for intramyocardial angiogenesis therapy. Results in normal and ischemic porcine models.
Journal of the American College of Cardiology 2000;35(4):1031-9.
2000: Ian Kirby; E Davison; Andrew John Beavil; C P Soh; Thomas J Wickham; Peter W Roelvink; Imre Kovesdi; Brian J Sutton; George Santis
Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein.
Journal of virology 2000;74(6):2804-13.
2000: Melina R Kibbe; A Murdock; Thomas J Wickham; Alena Lizonova; Imre Kovesdi; Suhua Nie; Lawrence Shears; Timothy R Billiar; Edith Tzeng
Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.
Archives of surgery (Chicago, Ill. : 1960) 2000;135(2):191-7.
2000: Melina R Kibbe; Suhua Nie; Dai-Wu Seol; Imre Kovesdi; Alena Lizonova; Michel S Makaroun; Timothy R Billiar; Edith Tzeng
Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells.
Journal of vascular surgery 2000;31(2):364-74.
2000: DC Cipolla; Igor Gonda; S Shak; Imre Kovesdi; Helen-Ann Brown Epstein; T D Sweeney
Coarse spray delivery to a localized region of the pulmonary airways for gene therapy.
Human gene therapy 2000;11(2):361-71.
2000: MJ Staba; T J Wickham; Imre Kovesdi; Dennis E Hallahan
Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models.
Cancer gene therapy 2000;7(1):13-9.
2000: Joseph T Bruder; A Appiah; W M Kirkman; P Chen; J Tian; D Reddy; Douglas E Brough; Alena Lizonova; Imre Kovesdi
Improved production of adenovirus vectors expressing apoptotic transgenes.
Human gene therapy 2000;11(1):139-49.
1999: Peter W Roelvink; G Mi Lee; David A Einfeld; Imre Kovesdi; Thomas J Wickham
Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae.
Science (New York, N.Y.) 1999;286(5444):1568-71.
1999: P Bezdicek; Stefan Worgall; Imre Kovesdi; M K Kim; J G Park; Theresa Vincent; Philip L Leopold; Alan D Schreiber; Helen-Ann Brown Epstein
Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver.
Blood 1999;94(10):3448-55.
1999: JC van Deutekom; Baohong Cao; Ryan Pruchnic; T J Wickham; Imre Kovesdi; Johnny Huard
Extended tropism of an adenoviral vector does not circumvent the maturation-dependent transducibility of mouse skeletal muscle.
The journal of gene medicine 1999;1(6):393-9.
1999: Ricardo Gonzalez; Rodolphe Vereecque; Thomas Wickham; T Facon; Dominique Hetuin; Imre Kovesdi; Francis Bauters; Pierre Fenaux; Bruno Quesnel
Transduction of bone marrow cells by the AdZ.F(pK7) modified adenovirus demonstrates preferential gene transfer in myeloma cells.
Human gene therapy 1999;10(16):2709-17.
1999: Ben-Gary Harvey; Philip L Leopold; Neil R Hackett; T M Grasso; P M Williams; A L Tucker; Robert J Kaner; Barbara Ferris; Igor Gonda; T D Sweeney; R Ramalingam; Imre Kovesdi; S Shak; Helen-Ann Brown Epstein
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
The Journal of clinical investigation 1999;104(9):1245-55.
1999: Ian Kirby; E Davison; Andrew John Beavil; C P Soh; Thomas J Wickham; Peter W Roelvink; Imre Kovesdi; Brian J Sutton; George Santis
Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.
Journal of virology 1999;73(11):9508-14.
1999: David A Einfeld; Douglas E Brough; Peter W Roelvink; Imre Kovesdi; Thomas J Wickham
Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base.
Journal of virology 1999;73(11):9130-6.
1999: Eric R Lechman; D Jaffurs; Steven C Ghivizzani; Andrea Gambotto; Imre Kovesdi; Zhibao Mi; Christopher H Evans; Paul D Robbins
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2202-8.
1999: Melina R Kibbe; Suhua Nie; T Yoneyama; K Hatakeyama; Alena Lizonova; Imre Kovesdi; Timothy R Billiar; Edith Tzeng
Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts.
Surgery 1999;126(2):323-9.
1999: Stefan Worgall; P Bezdicek; M K Kim; J G Park; R Singh; Melpo Christofidou-Solomidou; A Prince; Imre Kovesdi; Alan D Schreiber; Helen-Ann Brown Epstein
Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium.
The Journal of clinical investigation 1999;104(4):409-18.
1999: L Poliakova; Imre Kovesdi; X Wang; Maurizio C Capogrossi; Mark I Talan
Vascular permeability effect of adenovirus-mediated vascular endothelial growth factor gene transfer to the rabbit and rat skeletal muscle.
The Journal of thoracic and cardiovascular surgery 1999;118(2):339-47.
1999: DD Hegland; D M Sullivan; Ilsa I Rovira; A Li; Imre Kovesdi; JT Bruder; TOREN FINKEL
Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway.
Biochemical and biophysical research communications 1999;260(2):371-6.
1999: K Bouri; William G. Feero; Mike M Myerburg; Thomas J Wickham; Imre Kovesdi; Eric Hoffman; Paula R Clemens
Polylysine modification of adenoviral fiber protein enhances muscle cell transduction.
Human gene therapy 1999;10(10):1633-40.
1999: Olivier A Harari; T J Wickham; CJ Stocker; Imre Kovesdi; David M Segal; T Y Huehns; C Sarraf; Dorian O Haskard
Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin.
Gene therapy 1999;6(5):801-7.
1999: J D Whalen; E L Lechman; Casey A Carlos; K Weiss; Imre Kovesdi; Joseph C Glorioso; Paul D Robbins; Christopher H Evans
Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3625-32.
1999: Glenn A McDonald; G Zhu; Y Li; Imre Kovesdi; T J Wickham; Vikas P Sukhatme
Efficient adenoviral gene transfer to kidney cortical vasculature utilizing a fiber modified vector.
The journal of gene medicine 1999;1(2):103-10.
1999: Ricardo Gonzalez; Rodolphe Vereecque; Thomas Wickham; M Vanrumbeke; Imre Kovesdi; Francis Bauters; Pierre Fenaux; Bruno Quesnel
Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein.
Gene therapy 1999;6(3):314-20.
1999: AM Doanes; DD Hegland; R Sethi; Imre Kovesdi; JT Bruder; TOREN FINKEL
VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
Biochemical and biophysical research communications 1999;255(2):545-8.
1999: Chisa Hidaka; E Milano; Philip L Leopold; Jeffrey M Bergelson; Neil R Hackett; RW Finberg; Thomas J Wickham; Imre Kovesdi; Peter W Roelvink; Helen-Ann Brown Epstein
CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.
The Journal of clinical investigation 1999;103(4):579-87.
1999: Andrea Gambotto; Thomas Tüting; D L McVey; Imre Kovesdi; Hideaki Tahara; Michael T Lotze; Paul D Robbins
Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12.
Cancer gene therapy 1999;6(1):45-53.
1998: Peter W Roelvink; Alena Lizonova; J G Lee; Y Li; Jeffrey M Bergelson; RW Finberg; Douglas E Brough; Imre Kovesdi; Thomas J Wickham
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F.
Journal of virology 1998;72(10):7909-15.
1998: Lawrence Shears; Melina R Kibbe; A D Murdock; Timothy R Billiar; Alena Lizonova; Imre Kovesdi; simon simon watkins; Edith Tzeng
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo.
Journal of the American College of Surgeons 1998;187(3):295-306.
1998: JB Pracyk; K Tanaka; DD Hegland; KS Kim; R Sethi; Ilsa I Rovira; D R Blazina; L Lee; JT Bruder; Imre Kovesdi; P J Goldshmidt-Clermont; Kaikobad Irani; TOREN FINKEL
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
The Journal of clinical investigation 1998;102(5):929-37.
1998: Edith Tzeng; Timothy R Billiar; D L Williams; Juan Li; Alena Lizonova; Imre Kovesdi; Young-Myeong Kim
Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis.
Surgery 1998;124(2):278-83.
1998: P K Foreman; M J Wainwright; B Alicke; Imre Kovesdi; T J Wickham; J G Smith; S Meier-Davis; J A Fix; Peter E Daddona; P Gardner; M T Huang
Adenovirus-mediated transduction of intestinal cells in vivo.
Human gene therapy 1998;9(9):1313-21.
1998: KS Kim; Kazuyo Takeda; R Sethi; JB Pracyk; K Tanaka; Y F Zhou; Zu-Xi Yu; Victor J Ferrans; JT Bruder; Imre Kovesdi; Kaikobad Irani; Pascal J Goldschmidt-Clermont; TOREN FINKEL
Protection from reoxygenation injury by inhibition of rac1.
The Journal of clinical investigation 1998;101(9):1821-6.
1998: HL Kong; D Hecht; W Song; Imre Kovesdi; Neil R Hackett; A Yayon; Helen-Ann Brown Epstein
Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor.
Human gene therapy 1998;9(6):823-33.
1998: P Chen; J Tian; Imre Kovesdi; JT Bruder
Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis.
The Journal of biological chemistry 1998;273(10):5815-20.
1998: K Yamasaki; Howard D Edington; C McClosky; Edith Tzeng; Alena Lizonova; Imre Kovesdi; David Steed; Timothy R Billiar
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.
The Journal of clinical investigation 1998;101(5):967-71.
1998: Charles A Mack; SR Patel; E A Schwarz; Pat Zanzonico; Rebecca T Hahn; A Ilercil; Richard B Devereux; S J Goldsmith; T F Christian; Timothy A Sanborn; Imre Kovesdi; Neil R Hackett; O Wayne Isom; Helen-Ann Brown Epstein; Todd K Rosengart
Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart.
The Journal of thoracic and cardiovascular surgery 1998;115(1):168-76; discussion 176-7.
1997: Douglas E Brough; C Hsu; V A Kulesa; G M Lee; L J Cantolupo; Alena Lizonova; Imre Kovesdi
Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.
Journal of virology 1997;71(12):9206-13.
1997: T J Wickham; Dorian O Haskard; D Segal; Imre Kovesdi
Targeting endothelium for gene therapy via receptors up-regulated during angiogenesis and inflammation.
Cancer immunology, immunotherapy : CII 1997;45(3-4):149-51.
1997: Thomas J Wickham; Edith Tzeng; Lawrence Shears; Peter W Roelvink; Y Li; G M Lee; Douglas E Brough; Alena Lizonova; Imre Kovesdi
Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.
Journal of virology 1997;71(11):8221-9.
1997: Lawrence Shears; Nobuyoshi Kawaharada; Edith Tzeng; Timothy R Billiar; simon simon watkins; Imre Kovesdi; Alena Lizonova; Si Pham
Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.
The Journal of clinical investigation 1997;100(8):2035-42.
1997: Imre Kovesdi; Douglas E Brough; Joseph T Bruder; Thomas J Wickham
Adenoviral vectors for gene transfer.
Current opinion in biotechnology 1997;8(5):583-9.
1997: T J Wickham; G M Lee; J A Titus; G Sconocchia; T Bakács; Imre Kovesdi; David M Segal
Targeted adenovirus-mediated gene delivery to T cells via CD3.
Journal of virology 1997;71(10):7663-9.
1997: JT Bruder; T Jie; Duncan McVey; Imre Kovesdi
Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver.
Journal of virology 1997;71(10):7623-8.
1997: G Melillo; Marco Scoccianti; Imre Kovesdi; J Safi; Teresa Riccioni; Maurizio C Capogrossi
Gene therapy for collateral vessel development.
Cardiovascular research 1997;35(3):480-9.
1997: J Safi; T R Gloe; Teresa Riccioni; Imre Kovesdi; Maurizio C Capogrossi
Gene therapy with angiogenic factors: a new potential approach to the treatment of ischemic diseases.
Journal of molecular and cellular cardiology 1997;29(9):2311-25.
1997: Edith Tzeng; Young-Myeong Kim; Bruce R Pitt; Alena Lizonova; Imre Kovesdi; Timothy R Billiar
Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis.
Surgery 1997;122(2):255-63.
1997: Charles A Mack; WR Song; H Carpenter; Thomas J Wickham; Imre Kovesdi; Ben-Gary Harvey; CJ Magovern; O Wayne Isom; Todd K Rosengart; E Falck-Pedersen; Neil R Hackett; Helen-Ann Brown Epstein; A Mastrangeli
Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype.
Human gene therapy 1997;8(1):99-109.
1997: JT Bruder; Imre Kovesdi
Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression.
Journal of virology 1997;71(1):398-404.
1996: T J Wickham; Peter W Roelvink; Douglas E Brough; Imre Kovesdi
Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types.
Nature biotechnology 1996;14(11):1570-3.
1996: Peter W Roelvink; Imre Kovesdi; T J Wickham
Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment.
Journal of virology 1996;70(11):7614-21.
1996: T J Wickham; David M Segal; Peter W Roelvink; M E Carrion; Alena Lizonova; G M Lee; Imre Kovesdi
Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies.
Journal of virology 1996;70(10):6831-8.
1996: Douglas E Brough; Alena Lizonova; C Hsu; V A Kulesa; Imre Kovesdi
A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.
Journal of virology 1996;70(9):6497-501.
1996: A Mastrangeli; Ben-Gary Harvey; J Yao; Gerhard Wolff; Imre Kovesdi; Helen-Ann Brown Epstein; E Falck-Pedersen
"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.
Human gene therapy 1996;7(1):79-87.
1995: T J Wickham; M E Carrion; Imre Kovesdi
Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs.
Gene therapy 1995;2(10):750-6.
1995: J K Schwarz; C H Bassing; Imre Kovesdi; Michael B Datto; Michael A Blazing; S George; Xiao-Fan Wang; Joseph R Nevins
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(2):483-7.
1995: Bryan O'Hara; N A Jenkins; D J Gilbert; N G Copeland; T B Shows; R L Eddy; P Böhlen; Imre Kovesdi
Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man.
Cytogenetics and cell genetics 1995;69(1-2):40-3.
1994: A P Seddon; J D Hulmes; M M Decker; Imre Kovesdi; J L Fairhurst; J Backer; M Dougher-Vermazen; P Böhlen
Refolding and characterization of human recombinant heparin-binding neurite-promoting factor.
Protein expression and purification 1994;5(1):14-21.
1993: P J Kretschmer; J L Fairhurst; J D Hulmes; M L Popjes; P Böhlen; Imre Kovesdi
Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant.
Biochemical and biophysical research communications 1993;192(2):420-9.
1993: J L Fairhurst; P J Kretschmer; E Kovacs; P Böhlen; Imre Kovesdi
Structure of the gene coding for the human retinoic acid-inducible factor, MK.
DNA and cell biology 1993;12(2):139-47.
1993: J M Backer; C E Mendola; Imre Kovesdi; J L Fairhurst; Bryan O'Hara; R L Eddy; T B Shows; S Mathew; Vundavalli Murty; Raju S K Chaganti
Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2.
Oncogene 1993;8(2):497-502.
1992: B Bloch; E Normand; Imre Kovesdi; P Böhlen
Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: an in situ hybridization study.
Brain research. Developmental brain research 1992;70(2):267-78.
1991: J M Backer; C E Mendola; J L Fairhurst; Imre Kovesdi
The HIV-1 nef protein does not have guanine nucleotide binding, GTPase, or autophosphorylating activities.
AIDS research and human retroviruses 1991;7(12):1015-20.
1991: P Böhlen; T Müller; P Gautschi-Sova; U Albrecht; C G Rasool; M Decker; A Seddon; Veronique FAFEUR; Imre Kovesdi; P Kretschmer
Isolation from bovine brain and structural characterization of HBNF, a heparin-binding neurotrophic factor.
Growth factors (Chur, Switzerland) 1991;4(2):97-107.
1991: P Böhlen; Imre Kovesdi
HBNF and MK, members of a novel gene family of heparin-binding proteins with potential roles in embryogenesis and brain function.
Progress in growth factor research 1991;3(2):143-57.
1991: P J Kretschmer; J L Fairhurst; M M Decker; C P Chan; Y Gluzman; P Böhlen; Imre Kovesdi
Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.
Growth factors (Chur, Switzerland) 1991;5(2):99-114.
1991: A Seddon; M Decker; T Müller; D Armellino; Imre Kovesdi; Y Gluzman; P Böhlen
Structure/activity relationships in basic FGF.
Annals of the New York Academy of Sciences 1991;638():98-108.
1990: Imre Kovesdi; J L Fairhurst; P J Kretschmer; P Böhlen
Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins.
Biochemical and biophysical research communications 1990;172(2):850-4.
1989: R Reichel; S D Neill; Imre Kovesdi; M C Simon; Pradip Raychaudhuri; Joseph R Nevins
The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation.
Journal of virology 1989;63(9):3643-50.
1988: Joseph R Nevins; Pradip Raychaudhuri; Amy Yee; Robert J. Rooney; Imre Kovesdi; R Reichel
Transactivation by the adenovirus E1A gene.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(6):578-83.
1988: R Reichel; Imre Kovesdi; Joseph R Nevins
Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):387-90.
1987: Imre Kovesdi; M Satake; K Furukawa; R Reichel; Y Ito; Joseph R Nevins
A factor discriminating between the wild-type and a mutant polyomavirus enhancer.
Nature 1987;328(6125):87-9.
1987: Amy Yee; R Reichel; Imre Kovesdi; Joseph R Nevins
Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.
The EMBO journal 1987;6(7):2061-8.
1987: Imre Kovesdi; R Reichel; Joseph R Nevins
Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2180-4.
1987: R Reichel; Imre Kovesdi; Joseph R Nevins
Developmental control of a promoter-specific factor that is also regulated by the E1A gene product.
Cell 1987;48(3):501-6.
1986: Imre Kovesdi; R Reichel; Joseph R Nevins
Identification of a cellular transcription factor involved in E1A trans-activation.
Cell 1986;45(2):219-28.
1986: Imre Kovesdi; R Reichel; Joseph R Nevins
E1A transcription induction: enhanced binding of a factor to upstream promoter sequences.
Science (New York, N.Y.) 1986;231(4739):719-22.
1985: Imre Kovesdi; M J Smith
Quantitative assessment of actin transcript number in eggs, embryos, and tube feet of the sea star Pisaster ochraceus.
Molecular and cellular biology 1985;5(11):3001-8.
1984: Imre Kovesdi; F Preugschat; M Stuerzl; M J Smith
Actin genes from the sea star Pisaster ochraceus.
Biochimica et biophysica acta 1984;782(1):76-86.