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Khalid Iqbal

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Yanxing Chen; Chun-Ling Dai; Julie Blanchard; Inge Grundke-Iqbal; Khalid Iqbal; Moon H Lee; Zhihou Liang; Fei Liu; Shenggang Sun; Cheng-Xin Gong
A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).
Nana Jin; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Wei Qian; Xiaomin Yin; Lan Zhang; Fei Liu
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease.
Maria del Carmen Cardenas-Aguayo; Inge Grundke-Iqbal; Syed Faraz Kazim; Khalid Iqbal
Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures.

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2013: Yanxing Chen; Chun-Ling Dai; Julie Blanchard; Inge Grundke-Iqbal; Khalid Iqbal; Moon H Lee; Zhihou Liang; Fei Liu; Shenggang Sun; Cheng-Xin Gong
A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).
Molecular neurobiology 2013;47(2):711-25.
2013: Nana Jin; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Wei Qian; Xiaomin Yin; Lan Zhang; Fei Liu
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease.
Nucleic acids research 2013;41(5):3240-56.
2013: Maria del Carmen Cardenas-Aguayo; Inge Grundke-Iqbal; Syed Faraz Kazim; Khalid Iqbal
Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures.
PloS one 2013;8(1):e53596.
2013: Jian-Zhi Wang; Yi-Yuan Xia; Inge Grundke-Iqbal; Khalid Iqbal
Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S123-39.
2012: Jianhua Shi; Shiliang Wu; Chun-ling Dai; Inge Grundke-Iqbal; Khalid Iqbal; Yi Li; Fei Liu; Cheng-Xin Gong
Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells.
FEBS letters 2012;586(16):2443-50.
2012: Jianlan Gu; Inge-Grundke Iqbal; Khalid Iqbal; Nana Jin; Wei Qian; Jianhua Shi; Shiliang Wu; Jianhua Zhou; Cheng-Xin Gong; Fei Liu
Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.
FEBS letters 2012;586(16):2239-44.
2012: Shaohong Ding; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Wei Qian; Jianhua Shi; Fei Liu
Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A.
Neurobiology of aging 2012;33(7):1389-99.
2012: Yanxing Chen; Chun-Ling Dai; Inge Grundke-Iqbal; Khalid Iqbal; Frank M LaFerla; Moon H Lee; Zhihou Liang; Fei Liu; Shenggang Sun; Zhu Tian; Cheng-Xin Gong
Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease.
PloS one 2012;7(12):e51432.
2012: Ying Liu; Xiaoqin Run; Jianhua Shi; Yang Yu; Inge Grundke-Iqbal; Khalid Iqbal; Xiaojing Li; Yi Li; Zhihou Liang; Fei Liu; Chun-ling Dai; Cheng-Xin Gong
Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain.
PloS one 2012;7(8):e43724.
2012: Yang Yu; Lan Zhang; Inge Grundke-Iqbal; Khalid Iqbal; Moon H Lee; Xiaojing Li; Yi Li; Zhihou Liang; Fei Liu; Ying Liu; Xiaoqin Run; David J Vocadlo; Cheng-Xin Gong
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation.
PloS one 2012;7(4):e35277.
2011: Julie Blanchard; Silvia Bolognin; Muhammad Omar Chohan; Khalid Iqbal; Ausma Rabe; Inge Grundke-Iqbal
Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome.
Journal of neuropathology and experimental neurology 2011;70(12):1070-9.
2011: Khalid Iqbal; Inge Grundke-Iqbal
Opportunities and challenges in developing Alzheimer disease therapeutics.
Acta neuropathologica 2011;122(5):543-9.
2011: Lisette Arnaud; She Chen; Inge Grundke-Iqbal; Sabiha Khatoon; Bin Li; Fei Liu; Khalid Iqbal
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.
FEBS letters 2011;585(17):2653-9.
2011: Ying Liu; Inge Grundke-Iqbal; Khalid Iqbal; Fei Liu; Cheng-Xin Gong
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes.
The Journal of pathology 2011;225(1):54-62.
2011: Wei Qian; Jianhua Shi; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Nana Jin; Hongwei Liang; Fei Liu
Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A.
Nucleic acids research 2011;39(14):6161-71.
2011: Muhammad Omar Chohan; Julie Blanchard; Agnes T Heaney; Khalid Iqbal; Bin Li; Ausma Rabe; Yunn-Chyn Tung; Inge Grundke-Iqbal
Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide.
Neurobiology of aging 2011;32(8):1420-34.
2011: Niklas Mattsson; John McAuliffe; Marc Mercken; Abhay Moghekar; José Luis Molinuevo; Thomas J Montine; William Nowatzke; Richard J O'Brien; Markus Otto; George P Paraskevas; Lucilla Parnetti; Staffan Persson; Ronald C. Petersen; David Prvulovic; Robert A Rissman; Elio Scarpini; Johannes Schröder; Leslie M Shaw; Anders Skinningsrud; Brith Skrogstad; Hilkka Soininen; Annette Spreer; Alessandro Stefani; Leda Talib; Charlotte Teunissen; John Q Trojanowski; Hayrettin Tumani; Robert M Umek; Bianca Van Broeck; hugo Marcel vanderstichele; Laszlo Vecsei; Marcel M Verbeek; Manfred Windisch; Henrik Zetterberg; Jing Zhang; Luisella Bocchio-Chiavetto; Maria C Carrillo; Sonia Chalbot; Davide Chiasserini; Els Coart; Neal Cutler; Gunilla Dahlfors; Herman P M de Reus; Stefan Duller; Anne M Fagan; Orestes Forlenza; Giovanni B Frisoni; Douglas Galasko; Daniela Galimberti; Harald Hampel; Aase Handberg; Michael T Heneka; Adrianna Z Herskovits; Sanna-Kaisa Herukka; David M Holtzman; Christian Humpel; Bradley T Hyman; Khalid Iqbal; Mathias Jucker; Stephan A Kaeser; Elmar Kaiser; Elisabeth Kapaki; Daniel Kidd; Peter Klivenyi; Cindy S Knudsen; Markus P Kummer; Piotr Lewczuk; Qiao-Xin Li; Albert Lladó; James Lui; Ralph Martins; Colin L Masters; Ulf Andreasson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Marinus A Blankenstein; Kaj Blennow
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):386-395.e6.
2011: Jianhua Shi; Wei Qian; Xiaomin Yin; Khalid Iqbal; Inge Grundke-Iqbal; Xiaosong Gu; Fei Ding; Cheng-Xin Gong; Fei Liu
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.
The Journal of biological chemistry 2011;286(16):14639-48.
2011: Wei Qian; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong; Fei Liu
Splicing factor SC35 promotes tau expression through stabilization of its mRNA.
FEBS letters 2011;585(6):875-80.
2011: Sonia Chalbot; Tormod Fladby; Inge Grundke-Iqbal; Niels Andreasen; Kaj Blennow; Henrik Zetterberg; Khalid Iqbal
Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;25(3):505-15.
2011: Jerzy Wegiel; Wojciech Kaczmarski; Madhabi Barua; Izabela Kuchna; Krzysztof Nowicki; Kuo-Chiang Wang; Jarek Wegiel; Shuang Ma Yang; Janusz Frackowiak; Bozena Mazur-Kolecka; WAYNE SILVERMAN; Barry Reisberg; Isabel Monteiro; Mony J de Leon; Thomas Wisniewski; Arthur Dalton; Florence Lai; Yu-Wen Hwang; Tatyana Adayev; Fei Liu; Khalid Iqbal; Inge-Grundke Iqbal; Cheng-Xin Gong
Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.
Journal of neuropathology and experimental neurology 2011;70(1):36-50.
2011: Wei Qian; Xiaomin Yin; Wen Hu; Jianhua Shi; Jianlan Gu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong; Fei Liu
Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;23(4):617-27.
2010: Khalid Iqbal; Fei Liu; Cheng-Xin Gong; Inge Grundke-Iqbal
Tau in Alzheimer disease and related tauopathies.
Current Alzheimer research 2010;7(8):656-64.
2010: Julie Blanchard; Lukas Wanka; Yunn-Chyn Tung; María del Carmen Cárdenas-Aguayo; Frank M LaFerla; Khalid Iqbal; Inge Grundke-Iqbal
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Acta neuropathologica 2010;120(5):605-21.
2010: Xiaochuan Wang; Julie Blanchard; Erik Kohlbrenner; Nathalie Clement; R Michael Linden; Aurelian Radu; Inge Grundke-Iqbal; Khalid Iqbal
The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(11):4420-32.
2010: Alejandra D Alonso; John Di Clerico; Bin Li; Christopher P Corbo; Maria E Alaniz; Inge Grundke-Iqbal; Khalid Iqbal
Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration.
The Journal of biological chemistry 2010;285(40):30851-60.
2010: Khalid Iqbal; Inge Grundke-Iqbal
Alzheimer's disease, a multifactorial disorder seeking multitherapies.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2010;6(5):420-4.
2010: Bin Li; Lukas Wanka; Julie Blanchard; Fei Liu; Muhammad Omar Chohan; Khalid Iqbal; Inge Grundke-Iqbal
Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice.
FEBS letters 2010;584(15):3359-65.
2010: Khalid Iqbal; Xiaochuan Wang; Julie Blanchard; Fei Liu; Cheng-Xin Gong; Inge Grundke-Iqbal
Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial.
Biochemical Society transactions 2010;38(4):962-6.
2010: Sonia Chalbot; Henrik Zetterberg; Kaj Blennow; Tormod Fladby; Inge Grundke-Iqbal; Khalid Iqbal
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeability.
Neuroscience letters 2010;478(3):179-83.
2010: Norbert Zilka; Miroslava Korenova; Branislav Kovacech; Khalid Iqbal; Michal Novak
CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy.
Acta neuropathologica 2010;119(6):679-87.
2010: Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal
Targeting tau protein in Alzheimer's disease.
Drugs & aging 2010;27(5):351-65.
2010: Julie Blanchard; Muhammad Omar Chohan; Bin Li; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal
Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice.
Journal of Alzheimer's disease : JAD 2010;21(4):1185-95.
2010: Wei Qian; Jianhua Shi; Xiaomin Yin; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong; Fei Liu
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.
Journal of Alzheimer's disease : JAD 2010;19(4):1221-9.
2009: Sonia Chalbot; Henrik Zetterberg; Kaj Blennow; Tormod Fladby; Inge Grundke-Iqbal; Khalid Iqbal
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease.
Clinical chemistry 2009;55(12):2171-9.
2009: Yanqiu Deng; Bin Li; Ying Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.
The American journal of pathology 2009;175(5):2089-98.
2009: Ying Liu; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease.
Journal of neurochemistry 2009;111(1):242-9.
2009: Fei Liu; Jianhua Shi; Hitoshi Tanimukai; Jinhua Gu; Jianlan Gu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.
Brain : a journal of neurology 2009;132(Pt 7):1820-32.
2009: Khalid Iqbal; Fei Liu; Cheng-Xin Gong; Alejandra del C Alonso; Inge Grundke-Iqbal
Mechanisms of tau-induced neurodegeneration.
Acta neuropathologica 2009;118(1):53-69.
2009: Hitoshi Tanimukai; Takashi Kudo; Toshihisa Tanaka; Inge Grundke-Iqbal; Khalid Iqbal; Masatoshi Takeda
Novel therapeutic strategies for neurodegenerative disease.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2009;9(2):103-9.
2009: Yang Yu; Xiaoqin Run; Zhihou Liang; Yi Li; Fei Liu; Ying Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry 2009;108(6):1480-94.
2009: Zhihou Liang; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage.
Journal of Alzheimer's disease : JAD 2009;17(3):531-9.
2009: Xiaoqin Run; Zhihou Liang; Lan Zhang; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Anesthesia induces phosphorylation of tau.
Journal of Alzheimer's disease : JAD 2009;16(3):619-26.
2008: Jianhua Shi; Tianyi Zhang; Chunlei Zhou; Muhammad Omar Chohan; Xiaosong Gu; Jerzy Wegiel; Jianhua Zhou; Yu-Wen Hwang; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong; Fei Liu
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.
The Journal of biological chemistry 2008;283(42):28660-9.
2008: Khalid Iqbal; M Omar Chohan; Inge Grundke-Iqbal
Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2008;15(2):339-45.
2008: Fei Liu; Zhihou Liang; Jerzy Wegiel; Yu-Wen Hwang; Khalid Iqbal; Inge Grundke-Iqbal; Narayan Ramakrishna; Cheng-Xin Gong
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3224-33.
2008: Alejandra del C Alonso; Ben Li; Inge Grundke-Iqbal; Khalid Iqbal
Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.
Current Alzheimer research 2008;5(4):375-84.
2008: Khalid Iqbal; Alejandra del C Alonso; Inge Grundke-Iqbal
Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly.
Journal of Alzheimer's disease : JAD 2008;14(4):365-70.
2008: Xiao-Chuan Wang; Yin-Chun Zhang; Nithiananda Chatterjie; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Neurochemical research 2008;33(6):1138-44.
2008: She Chen; Bin Li; Inge Grundke-Iqbal; Khalid Iqbal
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
The Journal of biological chemistry 2008;283(16):10513-21.
2008: Zhihou Liang; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Jerzy Wegiel; Cheng-Xin Gong
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.
Journal of Alzheimer's disease : JAD 2008;13(3):295-302.
2008: Ying Liu; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease.
FEBS letters 2008;582(2):359-64.
2008: Cheng-Xin Gong; Khalid Iqbal
Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease.
Current medicinal chemistry 2008;15(23):2321-8.
2008: Khalid Iqbal; Inge Grundke-Iqbal
Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.
Journal of cellular and molecular medicine 2008;12(1):38-55.
2008: Bin Li; Hidenaga Yamamori; Yoshitaka Tatebayashi; Bridget Shafit-Zagardo; Hitoshi Tanimukai; She Chen; Khalid Iqbal; Inge Grundke-Iqbal
Failure of neuronal maturation in Alzheimer disease dentate gyrus.
Journal of neuropathology and experimental neurology 2008;67(1):78-84.
2008: Yanqiu Deng; Bin Li; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Roland Brandt; Cheng-Xin Gong
Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):138-45.
2007: Jozef Sevcik; Rostislav Skrabana; Radovan Dvorsky; Natalia Csokova; Khalid Iqbal; Michal Novak
X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease.
FEBS letters 2007;581(30):5872-8.
2007: Fei Liu; Bin Li; E-Jan Tung; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation.
The European journal of neuroscience 2007;26(12):3429-36.
2007: Zhihou Liang; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.
Journal of neurochemistry 2007;103(6):2462-70.
2007: Khalid Iqbal; Inge Grundke-Iqbal
Developing pharmacological therapies for Alzheimer disease.
Cellular and molecular life sciences : CMLS 2007;64(17):2234-44.
2007: Honghui Chen; Yunn-Chyn Tung; Bin Li; Khalid Iqbal; Inge Grundke-Iqbal
Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis.
Neurobiology of aging 2007;28(8):1148-62.
2007: Hidenaga Yamamori; Sabiha Khatoon; Inge Grundke-Iqbal; Kaj Blennow; Michael Ewers; Harald Hampel; Khalid Iqbal
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Neuroscience letters 2007;418(2):186-9.
2007: Bin Li; Muhammad Omar Chohan; Inge Grundke-Iqbal; Khalid Iqbal
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.
Acta neuropathologica 2007;113(5):501-11.
2007: Branislav Kovacech; Eva Kontsekova; Norbert Zilka; Pavol Novak; Rostislav Skrabana; Peter Filipcik; Khalid Iqbal; Michal Novak
A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain.
FEBS letters 2007;581(4):617-22.
2007: Jian-Zhi Wang; Inge Grundke-Iqbal; Khalid Iqbal
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
The European journal of neuroscience 2007;25(1):59-68.
2006: Amitabha Sengupta; Inge Grundke-Iqbal; Khalid Iqbal
Regulation of phosphorylation of tau by protein kinases in rat brain.
Neurochemical research 2006;31(12):1473-80.
2006: Fei Liu; Zhihou Liang; Jianhua Shi; Dongmei Yin; Ezzat El-Akkad; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
FEBS letters 2006;580(26):6269-74.
2006: Amitabha Sengupta; Michal Novak; Inge Grundke-Iqbal; Khalid Iqbal
Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.
FEBS letters 2006;580(25):5925-33.
2006: Muhammad Omar Chohan; Khalid Iqbal
From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;10(1):81-7.
2006: Muhammad Omar Chohan; Sabiha Khatoon; Inge Grundke-Iqbal; Khalid Iqbal
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.
FEBS letters 2006;580(16):3973-9.
2006: Alejandra del C Alonso; Bin Li; Inge Grundke-Iqbal; Khalid Iqbal
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8864-9.
2006: Xin-Wen Zhou; Xu Li; Cecilia Bjorkdahl; Magnus J Sjogren; Irina Alafuzoff; Hilkka Soininen; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Jin-Jing Pei
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains.
Neurobiology of disease 2006;22(3):657-68.
2006: Cheng-Xin Gong; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal
Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.
Journal of Alzheimer's disease : JAD 2006;9(1):1-12.
2006: A Rahman; Inge Grundke-Iqbal; Khalid Iqbal
PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(2):219-30.
2006: Inge Grundke-Iqbal; G Rolkova; E Konstekova; Khalid Iqbal
Biological markers in Alzheimer's disease.
Bratislavské lekárske listy 2006;107(9-10):359-65.
2006: M Pevalova; Peter Filipcik; Michal Novak; Jesús Avila; Khalid Iqbal
Post-translational modifications of tau protein.
Bratislavské lekárske listy 2006;107(9-10):346-53.
2006: Khalid Iqbal; M Novak
From tangles to tau protein.
Bratislavské lekárske listy 2006;107(9-10):341-2.
2006: Cheng-Xin Gong; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal
Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.
Journal of biomedicine & biotechnology 2006;2006(3):31825.
2006: Khalid Iqbal; Inge Grundke-Iqbal
Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):219-42.
2005: Alejandra del C Alonso; Khalid Iqbal
Tau-induced neurodegeneration: a clue to its mechanism.
Journal of Alzheimer's disease : JAD 2005;8(3):223-6.
2005: Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal; Yoshiya Oda; Kazuhito Tomizawa; Cheng-Xin Gong
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.
The Journal of biological chemistry 2005;280(45):37755-62.
2005: Khalid Iqbal; Michael Flory; Sabiha Khatoon; Hilkka Soininen; Tuula Pirttila; Maarit Lehtovirta; Irina Alafuzoff; Kaj Blennow; Niels Andreasen; Eugeen Vanmechelen; Inge Grundke-Iqbal
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.
Annals of neurology 2005;58(5):748-57.
2005: Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
The European journal of neuroscience 2005;22(8):1942-50.
2005: Muhammad Omar Chohan; Niloufar Haque; Alejandra del C Alonso; Ezzat El-Akkad; Inge Grundke-Iqbal; A Grover; Khalid Iqbal
Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(8):1035-47.
2005: George C Ruben; Jian-Zhi Wang; Khalid Iqbal; Inge Grundke-Iqbal
Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation.
Microscopy research and technique 2005;67(3-4):175-95.
2005: George C Ruben; Michal Novak; Patricia C Edwards; Khalid Iqbal
Alzheimer paired helical filaments (PHFs) studied by high-resolution TEM: what can vertical Pt-C replication tell us about the organization of the pronase-digested PHF core?
Microscopy research and technique 2005;67(3-4):196-209.
2005: Khalid Iqbal; Inge Grundke-Iqbal
Pharmacological approaches of neurofibrillary degeneration.
Current Alzheimer research 2005;2(3):335-41.
2005: J Wesson Ashford; Craig S Atwood; John P Blass; Richard L Bowen; Caleb E Finch; Khalid Iqbal; James A Joseph; George Perry
What is aging? What is its role in Alzheimer's disease? What can we do about it?
Journal of Alzheimer's disease : JAD 2005;7(3):247-53; discussion 255-62.
2005: Hitoshi Tanimukai; Inge Grundke-Iqbal; Khalid Iqbal
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.
The American journal of pathology 2005;166(6):1761-71.
2005: Cheng-Xin Gong; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal
Post-translational modifications of tau protein in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(6):813-38.
2005: Abdur Rahman; Inge Grundke-Iqbal; Khalid Iqbal
Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1.
Neurochemical research 2005;30(2):277-87.
2005: Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Sandra Rossie; Cheng-Xin Gong
Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.
The Journal of biological chemistry 2005;280(3):1790-6.
2005: Ichiro Tsujio; Tanweer Zaidi; Jiliu Xu; Leszek Kotula; Inge Grundke-Iqbal; Khalid Iqbal
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.
FEBS letters 2005;579(2):363-72.
2005: Yu Huang; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.
Neuroscience letters 2005;373(2):115-8.
2005: Li Sun; XiaoChuang Wang; Shengyuan Liu; Quan Wang; JianZhi Wang; Malika Bennecib; Cheng-Xin Gong; Amitabha Sengupta; Inge Grundke-Iqbal; Khalid Iqbal
Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.
FEBS letters 2005;579(1):251-8.
2005: Khalid Iqbal; Alejandra del C Alonso; She Chen; Muhammad Omar Chohan; Ezzat El-Akkad; Cheng-Xin Gong; Sabiha Khatoon; Bin Li; Fei Liu; Abdur Rahman; Hitoshi Tanimukai; Inge Grundke-Iqbal
Tau pathology in Alzheimer disease and other tauopathies.
Biochimica et biophysica acta 2005;1739(2-3):198-210.
2005: Jens Wiltfang; Piotr Lewczuk; Peter Riederer; Edna Grünblatt; Christoph Hock; Philip scheltens; Harald Hampel; hugo vanderstichele; Khalid Iqbal; Douglas Galasko; Lars Lannfelt; Markus Otto; Hermann Esselmann; Andreas Wolfram Henkel; Johannes Kornhuber; Kaj Blennow
Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2005;6(2):69-84.
2005: Khalid Iqbal; Inge Grundke-Iqbal
Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies.
Acta neuropathologica 2005;109(1):25-31.
2004: Yu Huang; Hitoshi Tanimukai; Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.
The European journal of neuroscience 2004;20(12):3489-97.
2004: Shi Jie Liu; Jia Yu Zhang; Hong Lian Li; Zheng-Yu Fang; Qun Wang; Heng Mei Deng; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
The Journal of biological chemistry 2004;279(48):50078-88.
2004: Niloufar Haque; Cheng-Xin Gong; Amitabha Sengupta; Khalid Iqbal; Inge Grundke-Iqbal
Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells.
Brain research. Molecular brain research 2004;129(1-2):163-70.
2004: Alejandra del C Alonso; Anna Mederlyova; Michal Novak; Inge Grundke-Iqbal; Khalid Iqbal
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations.
The Journal of biological chemistry 2004;279(33):34873-81.
2004: Khalid Iqbal; Inge Grundke-Iqbal
Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies.
Current drug targets 2004;5(6):495-502.
2004: Hitoshi Tanimukai; Inge Grundke-Iqbal; Khalid Iqbal
Inhibitors of protein phosphatase-2A: topography and subcellular localization.
Brain research. Molecular brain research 2004;126(2):146-56.
2004: Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Gerald W Hart; Cheng-Xin Gong
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10804-9.
2004: Rostislav Skrabana; Peter Kontsek; Anna Mederlyova; Khalid Iqbal; Michal Novak
Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423.
FEBS letters 2004;568(1-3):178-82.
2004: Liang Li; Amitabha Sengupta; Niloufar Haque; Inge Grundke-Iqbal; Khalid Iqbal
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
FEBS letters 2004;566(1-3):261-9.
2004: Yoshitaka Tatebayashi; Niloufar Haque; Yunn-Chyn Tung; Khalid Iqbal; Inge Grundke-Iqbal
Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport.
Journal of cell science 2004;117(Pt 9):1653-63.
2004: Cheng-Xin Gong; Fei Liu; Guoxin Wu; Sandra Rossie; Jerzy Wegiel; Liang Li; Inge Grundke-Iqbal; Khalid Iqbal
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Journal of neurochemistry 2004;88(2):298-310.
2003: Jin-Jing Pei; Cheng-Xin Gong; Wen-Lin An; Bengt Winblad; Richard Frank Cowburn; Inge Grundke-Iqbal; Khalid Iqbal
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
The American journal of pathology 2003;163(3):845-58.
2003: Wen-Lin An; Richard Frank Cowburn; Lin Li; Heiko Braak; Irina Alafuzoff; Khalid Iqbal; Inge Grundke-Iqbal; Bengt Winblad; Jin-Jing Pei
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.
The American journal of pathology 2003;163(2):591-607.
2003: Cheng-Xin Gong; Jian-Zhi Wang; Khalid Iqbal; Inge Grundke-Iqbal
Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices.
Neuroscience letters 2003;340(2):107-10.
2003: Jin-Jing Pei; Sabiha Khatoon; Wen-Lin An; Maria Nordlinder; Toshihisa Tanaka; Heiko Braak; Ichiro Tsujio; Masatoshi Takeda; Irina Alafuzoff; Bengt Winblad; Richard Frank Cowburn; Inge Grundke-Iqbal; Khalid Iqbal
Role of protein kinase B in Alzheimer's neurofibrillary pathology.
Acta neuropathologica 2003;105(4):381-92.
2003: Yoshitaka Tatebayashi; Moon H Lee; Liang Li; Khalid Iqbal; Inge Grundke-Iqbal
The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease.
Acta neuropathologica 2003;105(3):225-32.
2003: Qian Hua; Rong-Qiao He; N Haque; M H Qu; A del Carmen Alonso; Inge Grundke-Iqbal; Khalid Iqbal
Microtubule associated protein tau binds to double-stranded but not single-stranded DNA.
Cellular and molecular life sciences : CMLS 2003;60(2):413-21.
2003: Khalid Iqbal; Alejandra del C Alonso; Ezzat El-Akkad; Cheng-Xin Gong; Niloufar Haque; Sabiha Khatoon; Jin-Jing Pei; Hitoshi Tanimukai; Ichiro Tsujio; Jian-Zhi Wang; Inge Grundke-Iqba
Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays.
Journal of molecular neuroscience : MN 2003;20(3):425-9.
2002: Jin-Jing Pei; Heiko Braak; Wen-Lin An; Bengt Winblad; Richard Frank Cowburn; Khalid Iqbal; Inge Grundke-Iqbal
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.
Brain research. Molecular brain research 2002;109(1-2):45-55.
2002: Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
FEBS letters 2002;530(1-3):209-14.
2002: Jin-Jing Pei; Heiko Braak; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Richard Frank Cowburn
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration.
Acta neuropathologica 2002;104(4):369-76.
2002: Khalid Iqbal; Alejandra del C Alonso; Ezzat El-Akkad; Cheng-Xin Gong; Niloufar Haque; Sabiha Khatoon; Jin-Jing Pei; Ichiro Tsujio; Jian-Zhi Wang; Inge Grundke-Iqbal
Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion.
Journal of molecular neuroscience : MN 2002;19(1-2):95-9.
2002: Khalid Iqbal; Inge Grundke-Iqbal
Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.
Journal of Alzheimer's disease : JAD 2002;4(3):235-8.
2002: Yuan Yuan Hu; Shan-Shu He; Xiaochuan Wang; Qiu Hong Duan; Inge Grundke-Iqbal; Khalid Iqbal; Jianzhi Wang
Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.
The American journal of pathology 2002;160(4):1269-78.
2002: Yuan-Yuan Hu; Shan-Shu He; Xiao-Chuang Wang; Qiu-Hong Duan; Sabiha Khatoon; Khalid Iqbal; Inge Grundke-Iqbal; Jian-Zhi Wang
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients.
Neuroscience letters 2002;320(3):156-60.
2002: Jianzhi Wang; Xiaochuan Wang; Rong Liu; Qun Wang; Inge Grundke-Iqbal; Khalid Iqbal
In vitro analysis of tau phosphorylation sites and its biological activity.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 2002;17(1):13-6.
2002: Fei Liu; Tanweer Zaidi; Khalid Iqbal; Inge Grundke-Iqbal; Roberta K Merkle; Cheng-Xin Gong
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.
FEBS letters 2002;512(1-3):101-6.
2002: Khalid Iqbal; A del C Alonso; Ezzat El-Akkad; Cheng-Xin Gong; Niloufar Haque; Sabiha Khatoon; Ichiro Tsujio; Inge Grundke-Iqbal
Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.
Journal of neural transmission. Supplementum 2002;(62):309-19.
2002: Fei Liu; Tanweer Zaidi; Khalid Iqbal; Inge Grundke-Iqbal; Cheng-Xin Gong
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Neuroscience 2002;115(3):829-37.
2001: S Vijayan; Ezzat El-Akkad; Inge Grundke-Iqbal; Khalid Iqbal
A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain.
FEBS letters 2001;509(3):375-81.
2001: Jianzhi Wang; Y C Tung; Y Wang; X T Li; Khalid Iqbal; Inge Grundke-Iqbal
Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells.
FEBS letters 2001;507(1):81-7.
2001: A D Alonso; T Zaidi; M Novak; Héctor S Barra; Inge Grundke-Iqbal; Khalid Iqbal
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein.
The Journal of biological chemistry 2001;276(41):37967-73.
2001: Alejandra del C Alonso; T Zaidi; M Novak; Inge Grundke-Iqbal; Khalid Iqbal
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6923-8.
2001: Y Sato; Y Naito; Inge Grundke-Iqbal; Khalid Iqbal; Tamao Endo
Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease.
FEBS letters 2001;496(2-3):152-60.
2001: L Y Cheng; J Z Wang; Cheng-Xin Gong; Jin-Jing Pei; Tanweer Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities.
Neurochemical research 2001;26(4):425-38.
2001: Malika Bennecib; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
FEBS letters 2001;490(1-2):15-22.
2001: Cheng-Xin Gong; Theodore I Lidsky; Jerzy Wegiel; Inge Grundke-Iqbal; Khalid Iqbal
Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain.
Brain research. Brain research protocols 2001;6(3):134-40.
2000: Malika Bennecib; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.
FEBS letters 2000;485(1):87-93.
2000: Khalid Iqbal; Inge Grundke-Iqbal
Alzheimer disease is multifactorial and heterogeneous.
Neurobiology of aging 2000;21(6):901-2; discussion 903-4.
2000: Jianzhi Wang; Z Wei; Qun Wang; Inge Grundke-Iqbal; Khalid Iqbal
[Association of microtubule promoting and binding activity of tau with its phosphorylation sites].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2000;22(2):120-3.
2000: Ichiro Tsujio; Toshiyuki Tanaka; Takashi Kudo; T Nishikawa; K Shinozaki; Inge Grundke-Iqbal; Khalid Iqbal; Masatoshi Takeda
Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation.
FEBS letters 2000;469(1):111-7.
2000: Cheng-Xin Gong; Theodore I Lidsky; Jerzy Wegiel; L Zuck; Inge Grundke-Iqbal; Khalid Iqbal
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
The Journal of biological chemistry 2000;275(8):5535-44.
2000: Cheng-Xin Gong; Jerzy Wegiel; Theodore I Lidsky; L Zuck; Jesús Avila; Henryk M Wisniewski; Inge Grundke-Iqbal; Khalid Iqbal
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
Brain research 2000;853(2):299-309.
2000: Khalid Iqbal; A D Alonso; J A Gondal; Cheng-Xin Gong; Niloufar Haque; Sabiha Khatoon; Amitabha Sengupta; Jian-Zhi Wang; Inge Grundke-Iqbal
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.
Journal of neural transmission. Supplementum 2000;59():213-22.
2000: L Y Cheng; J Z Wang; Cheng-Xin Gong; Jin-Jing Pei; Tanweer Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases.
Neurochemical research 2000;25(1):107-20.
1999: Inge Grundke-Iqbal; Khalid Iqbal
Tau pathology generated by overexpression of tau.
The American journal of pathology 1999;155(6):1781-5.
1999: Jin-Jing Pei; Eva Braak; Heiko Braak; Inge Grundke-Iqbal; Khalid Iqbal; Bengt Winblad; Richard Frank Cowburn
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Journal of neuropathology and experimental neurology 1999;58(9):1010-9.
1999: Niloufar Haque; T Tanaka; Khalid Iqbal; Inge Grundke-Iqbal
Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells.
Brain research 1999;838(1-2):69-77.
1999: Yoshitaka Tatebayashi; Khalid Iqbal; Inge Grundke-Iqbal
Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5245-54.
1999: J Zhong; Khalid Iqbal; Inge Grundke-Iqbal
Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain.
FEBS letters 1999;453(1-2):224-8.
1999: Frank Hulstaert; Kaj Blennow; Adrian Ivanoiu; H C Schoonderwaldt; Matthias Riemenschneider; P P De Deyn; C Bancher; Patrick cras; J Wiltfang; Pankaj D Mehta; Khalid Iqbal; Hans Pottel; Eugeen Vanmechelen; hugo vanderstichele
Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF.
Neurology 1999;52(8):1555-62.
1998: Juan Sironi; Shu-Hui C. Yen; J A Gondal; Q Wu; Inge Grundke-Iqbal; Khalid Iqbal
Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.
FEBS letters 1998;436(3):471-5.
1998: J Z Wang; Q Wu; A Smith; Inge Grundke-Iqbal; Khalid Iqbal
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
FEBS letters 1998;436(1):28-34.
1998: Amitabha Sengupta; J Kabat; M Novak; Q Wu; Inge Grundke-Iqbal; Khalid Iqbal
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
Archives of biochemistry and biophysics 1998;357(2):299-309.
1998: Y Ikura; Takashi Kudo; Toshiyuki Tanaka; H Tanii; Inge Grundke-Iqbal; Khalid Iqbal; Masatoshi Takeda
Levels of tau phosphorylation at different sites in Alzheimer disease brain.
Neuroreport 1998;9(10):2375-9.
1998: Jin-Jing Pei; Inge Grundke-Iqbal; Khalid Iqbal; Nenad Bogdanovic; Bengt Winblad; Richard Frank Cowburn
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.
Brain research 1998;797(2):267-77.
1998: T Tanaka; J Zhong; Khalid Iqbal; E Trenkner; Inge Grundke-Iqbal
The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.
FEBS letters 1998;426(2):248-54.
1998: Khalid Iqbal; Inge Grundke-Iqbal
Tau phosphatase activity as a therapeutic target for AD.
Drug news & perspectives 1998;11(1):10-4.
1998: Khalid Iqbal; A C Alonso; Cheng-Xin Gong; Sabiha Khatoon; Jin-Jing Pei; Jian-Zhi Wang; Inge Grundke-Iqbal
Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.
Journal of neural transmission. Supplementum 1998;53():169-80.
1998: Jin-Jing Pei; Cheng-Xin Gong; Khalid Iqbal; Inge Grundke-Iqbal; Q L Wu; Bengt Winblad; Richard Frank Cowburn
Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(1):69-83.
1997: George C Ruben; T L Ciardelli; Inge Grundke-Iqbal; Khalid Iqbal
Alzheimer disease hyperphosphorylated tau aggregates hydrophobically.
Synapse (New York, N.Y.) 1997;27(3):208-29.
1997: Khalid Iqbal; Inge Grundke-Iqbal
Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles.
Molecular psychiatry 1997;2(3):178-80.
1997: T J Singh; Inge Grundke-Iqbal; W Q Wu; V Chauhan; M Novak; E Kontzekova; Khalid Iqbal
Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.
Molecular and cellular biochemistry 1997;168(1-2):141-8.
1997: Amitabha Sengupta; Q Wu; Inge Grundke-Iqbal; Khalid Iqbal; T J Singh
Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.
Molecular and cellular biochemistry 1997;167(1-2):99-105.
1997: A D Alonso; Inge Grundke-Iqbal; Héctor S Barra; Khalid Iqbal
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):298-303.
1997: Jin-Jing Pei; Inge Grundke-Iqbal; Khalid Iqbal; Nenad Bogdanovic; Bengt Winblad; Richard Frank Cowburn
Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1329-38.
1997: Khalid Iqbal; Inge Grundke-Iqbal
Elevated levels of tau and ubiquitin in brain and cerebrospinal fluid in Alzheimer's disease.
International psychogeriatrics / IPA 1997;9 Suppl 1():289-96; discussion 317-21.
1997: Jin-Jing Pei; T Tanaka; Y C Tung; Eva Braak; Khalid Iqbal; Inge Grundke-Iqbal
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1997;56(1):70-8.
1996: Cheng-Xin Gong; S Shaikh; Inge Grundke-Iqbal; Khalid Iqbal
Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics.
Brain research 1996;741(1-2):95-102.
1996: J Z Wang; Inge Grundke-Iqbal; Khalid Iqbal
Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.
Nature medicine 1996;2(8):871-5.
1996: A C Alonso; Inge Grundke-Iqbal; Khalid Iqbal
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.
Nature medicine 1996;2(7):783-7.
1996: T J Singh; J Z Wang; M Novak; E Kontzekova; Inge Grundke-Iqbal; Khalid Iqbal
Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules.
FEBS letters 1996;387(2-3):145-8.
1996: J Z Wang; Inge Grundke-Iqbal; Khalid Iqbal
Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.
Brain research. Molecular brain research 1996;38(2):200-8.
1996: T J Singh; Inge Grundke-Iqbal; Khalid Iqbal
Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases.
Archives of biochemistry and biophysics 1996;328(1):43-50.
1996: T J Singh; T Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.
Molecular and cellular biochemistry 1996;154(2):143-51.
1996: Khalid Iqbal; Inge Grundke-Iqbal
Molecular mechanism of Alzheimer's neurofibrillary degeneration and therapeutic intervention.
Annals of the New York Academy of Sciences 1996;777():132-8.
1995: Cheng-Xin Gong; S Shaikh; J Z Wang; T Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.
Journal of neurochemistry 1995;65(2):732-8.
1995: A del C Alonso; Inge Grundke-Iqbal; Khalid Iqbal
Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease.
Brain research. Molecular brain research 1995;31(1-2):194-200.
1995: George C Ruben; M Novak; P C Edwards; Khalid Iqbal
Alzheimer paired helical filaments, untreated and pronase digested, studied by vertical platinum-carbon replication and high resolution transmission electron microscopy.
Brain research 1995;675(1-2):1-12.
1995: J Z Wang; Cheng-Xin Gong; T Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.
The Journal of biological chemistry 1995;270(9):4854-60.
1995: T J Singh; Inge Grundke-Iqbal; Khalid Iqbal
Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state.
Journal of neurochemistry 1995;64(3):1420-3.
1995: N Haque; Robert B Denman; G Merz; Inge Grundke-Iqbal; Khalid Iqbal
Phosphorylation and accumulation of tau without any concomitant increase in tubulin levels in Chinese hamster ovary cells stably transfected with human tau441.
FEBS letters 1995;360(2):132-6.
1995: T Tanaka; Khalid Iqbal; Ekkhart Trenkner; D J Liu; Inge Grundke-Iqbal
Abnormally phosphorylated tau in SY5Y human neuroblastoma cells.
FEBS letters 1995;360(1):5-9.
1995: S Khatoon; Inge Grundke-Iqbal; Khalid Iqbal
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.
Journal of neurochemistry 1995;64(2):777-87.
1995: T J Singh; N Haque; Inge Grundke-Iqbal; Khalid Iqbal
Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.
FEBS letters 1995;358(3):267-72.
1995: T J Singh; T Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases.
FEBS letters 1995;358(1):4-8.
1994: S Khatoon; Inge Grundke-Iqbal; Khalid Iqbal
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains.
FEBS letters 1994;351(1):80-4.
1994: Jin-Jing Pei; Eugene A Sersen; Khalid Iqbal; Inge Grundke-Iqbal
Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.
Brain research 1994;655(1-2):70-6.
1994: Khalid Iqbal; A C Alonso; Cheng-Xin Gong; S Khatoon; T J Singh; Inge Grundke-Iqbal
Mechanism of neurofibrillary degeneration in Alzheimer's disease.
Molecular neurobiology 1994;9(1-3):119-23.
1994: Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal
Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.
Neuroscience 1994;61(4):765-72.
1994: Khalid Iqbal; T Zaidi; C Bancher; Inge Grundke-Iqbal
Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.
FEBS letters 1994;349(1):104-8.
1994: T Kudo; Khalid Iqbal; R Ravid; Dick F Swaab; Inge Grundke-Iqbal
Ubiquitin in cerebrospinal fluid: a rapid competitive enzyme-linked immunoflow assay.
Neuroreport 1994;5(12):1522-4.
1994: A C Alonso; T Zaidi; Inge Grundke-Iqbal; Khalid Iqbal
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5562-6.
1994: Cheng-Xin Gong; Inge Grundke-Iqbal; Z Damuni; Khalid Iqbal
Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.
FEBS letters 1994;341(1):94-8.
1994: T Kudo; Khalid Iqbal; Rivka Ravid; Dick F Swaab; Inge Grundke-Iqbal
Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels.
Brain research 1994;639(1):1-7.
1994: T J Singh; Inge Grundke-Iqbal; B McDonald; Khalid Iqbal
Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases.
Molecular and cellular biochemistry 1994;131(2):181-9.
1994: Cheng-Xin Gong; T J Singh; Inge Grundke-Iqbal; Khalid Iqbal
Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).
Journal of neurochemistry 1994;62(2):803-6.
1994: A Rehman; Y C Tung; Khalid Iqbal; Inge Grundke-Iqbal
Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles.
Acta neuropathologica 1994;87(5):443-9.
1993: E Köpke; Y C Tung; S Shaikh; A C Alonso; Khalid Iqbal; Inge Grundke-Iqbal
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
The Journal of biological chemistry 1993;268(32):24374-84.
1993: Cheng-Xin Gong; T J Singh; Inge Grundke-Iqbal; Khalid Iqbal
Phosphoprotein phosphatase activities in Alzheimer disease brain.
Journal of neurochemistry 1993;61(3):921-7.
1993: David L Miller; Ioannis Papayannopoulos; J Styles; S A Bobin; Y Y Lin; Klaus Biemann; Khalid Iqbal
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.
Archives of biochemistry and biophysics 1993;301(1):41-52.
1993: George C Ruben; Khalid Iqbal; Henryk M Wisniewski; J E Johnson; Inge Grundke-Iqbal
Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid.
Brain research 1993;602(2):164-79.
1993: George C Ruben; Khalid Iqbal; Inge Grundke-Iqbal; J E Johnson
The organization of the microtubule associated protein tau in Alzheimer paired helical filaments.
Brain research 1993;602(1):1-13.
1993: Khalid Iqbal; A Alonso; Cheng-Xin Gong; S Khatoon; T Kudo; T Singh; Inge Grundke-Iqbal
Molecular pathology of Alzheimer neurofibrillary degeneration.
Acta neurobiologiae experimentalis 1993;53(1):325-35.
1992: Dick F Swaab; Inge Grundke-Iqbal; Khalid Iqbal; H P Kremer; Rivka Ravid; J A van de Nes
Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease.
Brain research 1992;590(1-2):239-49.
1992: S Khatoon; Inge Grundke-Iqbal; Khalid Iqbal
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.
Journal of neurochemistry 1992;59(2):750-3.
1992: M A Wrzolek; P A Merz; Richard J Kascsak; Inge Grundke-Iqbal; Khalid Iqbal; Richard Rubenstein; M Tonna-DeMasi; N L Goller; P Mehta; Henryk M Wisniewski
Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles.
The American journal of pathology 1992;141(2):343-55.
1992: F H Lin; R Lin; Henryk M Wisniewski; Y W Hwang; Inge Grundke-Iqbal; G Healy-Louie; Khalid Iqbal
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.
Biochemical and biophysical research communications 1992;182(1):238-46.
1992: Janusz Frackowiak; Henryk M Wisniewski; Jerzy Wegiel; G S Merz; Khalid Iqbal; K C Wang
Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils.
Acta neuropathologica 1992;84(3):225-33.
1991: G P Wang; S Khatoon; Khalid Iqbal; Inge Grundke-Iqbal
Brain ubiquitin is markedly elevated in Alzheimer disease.
Brain research 1991;566(1-2):146-51.
1991: George C Ruben; Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski; T L Ciardelli; J E Johnson
The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer.
The Journal of biological chemistry 1991;266(32):22019-27.
1991: S Lake; Bengt Winblad; Khalid Iqbal
Second International Conference on Alzheimer's Disease and Related Disorders, Toronto, 1990: review of current research.
Neurobiology of aging 1991;12(5):609-12.
1991: Khalid Iqbal; Eva Braak; Heiko Braak; T Zaidi; Inge Grundke-Iqbal
A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Neurobiology of aging 1991;12(4):357-61.
1991: L R Murthy; Khalid Iqbal
Measurement of picomoles of phosphoamino acids by high-performance liquid chromatography.
Analytical biochemistry 1991;193(2):299-305.
1991: C Bancher; Inge Grundke-Iqbal; Khalid Iqbal; V A Fried; HT Smith; Henryk M Wisniewski
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease.
Brain research 1991;539(1):11-8.
1991: Khalid Iqbal; Inge Grundke-Iqbal
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.
Molecular neurobiology 1991;5(2-4):399-410.
1991: G P Wang; Khalid Iqbal; G Bucht; Bengt Winblad; Henryk M Wisniewski; Inge Grundke-Iqbal
Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid.
Acta neuropathologica 1991;82(1):6-12.
1990: Inge Grundke-Iqbal; J Fleming; Y C Tung; H Lassmann; Khalid Iqbal; J G Joshi
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.
Acta neuropathologica 1990;81(2):105-10.
1989: Henryk M Wisniewski; Khalid Iqbal; C Bancher; D Miller; J Currie
Cytoskeletal protein pathology and the formation of beta-amyloid fibers in Alzheimer's disease.
Neurobiology of aging 1989;10(5):409-12; discussion 412-4.
1989: Khalid Iqbal; Inge Grundke-Iqbal; A J Smith; L George; Y C Tung; T Zaidi
Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5646-50.
1989: Khalid Iqbal; A J Smith; T Zaidi; Inge Grundke-Iqbal
Microtubule-associated protein tau. Identification of a novel peptide from bovine brain.
FEBS letters 1989;248(1-2):87-91.
1989: George Perry; P Mulvihill; V A Fried; HT Smith; Inge Grundke-Iqbal; Khalid Iqbal
Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease.
Journal of neurochemistry 1989;52(5):1523-8.
1989: Inge Grundke-Iqbal; Khalid Iqbal; L George; Y C Tung; K S Kim; Henryk M Wisniewski
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2853-7.
1989: C Bancher; Inge Grundke-Iqbal; Khalid Iqbal; K S Kim; Henryk M Wisniewski
Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid beta-protein.
Neurobiology of aging 1989;10(2):125-32.
1989: Khalid Iqbal
First International Conference on Alzheimer's Disease and Related Disorders.
Neurobiology of aging 1989;10(2):211-5.
1989: Christian Bancher; C Brunner; H Lassmann; Herbert Budka; Kurt A Jellinger; Gerhard Wiche; F Seitelberger; Inge Grundke-Iqbal; Khalid Iqbal; Henryk M Wisniewski
Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease.
Brain research 1989;477(1-2):90-9.
1989: C Bancher; Inge Grundke-Iqbal; Khalid Iqbal; K S Kim; Henryk M Wisniewski
A 31 kilodalton beta-protein immunoreactive polypeptide in neuronal lipofuscin.
Progress in clinical and biological research 1989;317():913-24.
1989: S Khatoon; Khalid Iqbal
Exchangeable GTP binding site of the beta-subunit of brain tubulin in Alzheimer disease.
Progress in clinical and biological research 1989;317():801-7.
1989: Inge Grundke-Iqbal; Khalid Iqbal
Neuronal cytoskeleton in the biology of Alzheimer disease.
Progress in clinical and biological research 1989;317():745-53.
1989: Khalid Iqbal; G P Wang; Inge Grundke-Iqbal; Henryk M Wisniewski
Laboratory diagnostic tests for Alzheimer's disease.
Progress in clinical and biological research 1989;317():679-87.
1989: Irina Alafuzoff; Khalid Iqbal; H Friden; R Adolfsson; Bengt Winblad
Histopathological classification of dementias by multivariate data analysis.
Progress in clinical and biological research 1989;317():295-301.
1989: David L Miller; Julia R Currie; Khalid Iqbal; Anna Potempska; J Styles
Relationships among the cerebral amyloid peptides and their precursors.
Annals of medicine 1989;21(2):83-7.
1989: Christian Bancher; C Brunner; H Lassmann; Herbert Budka; Kurt A Jellinger; F Seitelberger; Inge Grundke-Iqbal; Khalid Iqbal; Henryk M Wisniewski
Tau and ubiquitin immunoreactivity at different stages of formation of Alzheimer neurofibrillary tangles.
Progress in clinical and biological research 1989;317():837-48.
1989: Christian Bancher; H Lassmann; Herbert Budka; Kurt A Jellinger; Inge Grundke-Iqbal; Khalid Iqbal; Gerhard Wiche; F Seitelberger; Henryk M Wisniewski
An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination.
Journal of neuropathology and experimental neurology 1989;48(1):81-93.
1988: P G Galloway; Inge Grundke-Iqbal; Khalid Iqbal; George Perry
Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles.
Journal of neuropathology and experimental neurology 1988;47(6):654-63.
1988: Inge Grundke-Iqbal; Andrzej W Vorbrodt; Khalid Iqbal; Y C Tung; G P Wang; Henryk M Wisniewski
Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments.
Brain research 1988;464(1):43-52.
1987: Khalid Iqbal; Inge Grundke-Iqbal; P A Merz; Henryk M Wisniewski; T Zaidi
In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS.
Brain research 1987;388(2):163-72.
1987: Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski
Alzheimer's disease, microtubule and neurofilament proteins, and axoplasmic flow.
Lancet 1987;1(8524):102.
1987: Irina Alafuzoff; Khalid Iqbal; H Friden; R Adolfsson; Bengt Winblad
Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis.
Acta neuropathologica 1987;74(3):209-25.
1987: Henryk M Wisniewski; Khalid Iqbal; Inge Grundke-Iqbal; R Rubenstein
The solubility controversy of paired helical filaments: a commentary.
Neurochemical research 1987;12(1):93-5.
1987: Christian Bancher; H Lassmann; Herbert Budka; Inge Grundke-Iqbal; Khalid Iqbal; Gerhard Wiche; F Seitelberger; Henryk M Wisniewski
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Acta neuropathologica 1987;74(1):39-46.
1986: Khalid Iqbal; Inge Grundke-Iqbal; T Zaidi; P A Merz; G Y Wen; S S Shaikh; Henryk M Wisniewski; Irina Alafuzoff; Bengt Winblad
Defective brain microtubule assembly in Alzheimer's disease.
Lancet 1986;2(8504):421-6.
1986: Inge Grundke-Iqbal; Khalid Iqbal; Y C Tung; M Quinlan; Henryk M Wisniewski; L I Binder
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4913-7.
1986: Khalid Iqbal; Inge Grundke-Iqbal; T Zaidi; N Ali; Henryk M Wisniewski
Are Alzheimer neurofibrillary tangles insoluble polymers?
Life sciences 1986;38(18):1695-700.
1986: Inge Grundke-Iqbal; Khalid Iqbal; M Quinlan; Y C Tung; M S Zaidi; Henryk M Wisniewski
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
The Journal of biological chemistry 1986;261(13):6084-9.
1986: Richard Rubenstein; Richard J Kascsak; P A Merz; Henryk M Wisniewski; Richard I Carp; Khalid Iqbal
Paired helical filaments associated with Alzheimer disease are readily soluble structures.
Brain research 1986;372(1):80-8.
1986: Heiko Braak; Eva Braak; Inge Grundke-Iqbal; Khalid Iqbal
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.
Neuroscience letters 1986;65(3):351-5.
1986: Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski
Neuronal cytoskeleton in aging and dementia.
Progress in brain research 1986;70():279-88.
1985: Henryk M Wisniewski; J A Sturman; J W Shek; Khalid Iqbal
Aluminum and the central nervous system.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1985;6(1):1-8.
1985: P D Mehta; Leon J Thal; Henryk M Wisniewski; Inge Grundke-Iqbal; Khalid Iqbal
Paired helical filament antigen in CSF.
Lancet 1985;2(8445):35.
1985: M Benuck; Khalid Iqbal; Henryk M Wisniewski; A Lajtha
Proteolytic activity in brains of rabbits treated with aluminum.
Neurochemical research 1985;10(6):729-36.
1985: Khalid Iqbal; R A Somerville; C H Thompson; Henryk M Wisniewski
Brain glutamate decarboxylase and cholinergic enzyme activities in scrapie.
Journal of the neurological sciences 1985;67(3):345-50.
1985: Inge Grundke-Iqbal; Khalid Iqbal; Y C Tung; G P Wang; Henryk M Wisniewski
Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain.
Acta neuropathologica 1985;66(1):52-61.
1985: Inge Grundke-Iqbal; G P Wang; Khalid Iqbal; Y C Tung; Henryk M Wisniewski
Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.
Acta neuropathologica 1985;68(4):279-83.
1984: Henryk M Wisniewski; P A Merz; Khalid Iqbal
Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle.
Journal of neuropathology and experimental neurology 1984;43(6):643-56.
1984: K Vass; H Lassmann; Henryk M Wisniewski; Khalid Iqbal
Ultracytochemical distribution of myelin basic protein after injection into the cerebrospinal fluid. Evidence for transport through the blood-brain barrier and binding to the luminal surface of cerebral veins.
Journal of the neurological sciences 1984;63(3):423-33.
1984: G P Wang; Inge Grundke-Iqbal; R J Kascsak; Khalid Iqbal; Henryk M Wisniewski
Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s).
Acta neuropathologica 1984;62(4):268-75.
1984: Khalid Iqbal; T Zaidi; C H Thompson; P A Merz; Henryk M Wisniewski
Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition.
Acta neuropathologica 1984;62(3):167-77.
1984: Inge Grundke-Iqbal; Khalid Iqbal; Y C Tung; Henryk M Wisniewski
Alzheimer paired helical filaments: immunochemical identification of polypeptides.
Acta neuropathologica 1984;62(4):259-67.
1983: M N Malik; M D Fenko; Khalid Iqbal; Henryk M Wisniewski
Purification and characterization of two forms of Ca2+-activated neutral protease from calf brain.
The Journal of biological chemistry 1983;258(14):8955-62.
1983: P A Merz; Henryk M Wisniewski; R A Somerville; S A Bobin; Colin L Masters; Khalid Iqbal
Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques.
Acta neuropathologica 1983;60(1-2):113-24.
1982: K Wisniewski; H Czosnek; Henryk M Wisniewski; D Soifer; P L Ramos; K S Kim; Khalid Iqbal
Reduction of neuronal specific protein and some neurotransmitters in the infantile neuroaxonal dystrophy (INAD).
Neuropediatrics 1982;13(3):123-9.
1982: Khalid Iqbal; Inge Grundke-Iqbal; P A Merz; Henryk M Wisniewski
Alzheimer Neurofibrillary tangle: morphology and biochemistry.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;Suppl 5():10-4.
1982: Inge Grundke-Iqbal; Khalid Iqbal; Henryk M Wisniewski
Immunocytochemical studies on neurofibrillary changes.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;Suppl 5():20-5.
1981: M N Malik; L A Meyers; Khalid Iqbal; A M Sheikh; L Scotto; Henryk M Wisniewski
Calcium activated proteolysis of fibrous proteins in central nervous system.
Life sciences 1981;29(8):795-802.
1981: J D Dziedzic; Henryk M Wisniewski; Khalid Iqbal
Monoamine oxidase activity in normal and Alzheimer brains.
Annals of neurology 1981;9(6):618-9.
1981: R E Madrid; Henryk M Wisniewski; Khalid Iqbal; Raju K Pullarkat; H Lassmann
Relapsing experimental allergic encephalomyelitis induced with isolated myelin and with myelin basic protein plus myelin lipids.
Journal of the neurological sciences 1981;50(3):399-411.
1981: D Soifer; Khalid Iqbal; H Czosnek; J De Martini; J A Sturman; Henryk M Wisniewski
The loss of neuron-specific proteins during the course of Wallerian degeneration of optic and sciatic nerve.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1981;1(5):461-70.
1981: S A Bobin; Henryk M Wisniewski; F J Kieras; Khalid Iqbal
Morphological and chemical characterization of a starch granule-like polyglucosan deposit isolated from human brain.
Acta neuropathologica 1981;55(1):47-52.
1981: P A Merz; R A Somerville; Henryk M Wisniewski; Khalid Iqbal
Abnormal fibrils from scrapie-infected brain.
Acta neuropathologica 1981;54(1):63-74.
1980: Khalid Iqbal; J H Ottaway
Improved sensitivity of glutamine synthetase assay and of acyl hydroxamates.
Neurochemical research 1980;5(7):805-8.
1980: G Constantopoulos; Khalid Iqbal; A S Dekaban
Mucopolysaccharidosis types IH, IS, II, and IIIA: glycosaminoglycans and lipids of isolated brain cells and other fractions from autopsied tissues.
Journal of neurochemistry 1980;34(6):1399-411.
1980: B Hetnarski; Henryk M Wisniewski; Khalid Iqbal; J D Dziedzic; A Lajtha
Central cholinergic activity in aluminum-induced neurofibrillary degeneration.
Annals of neurology 1980;7(5):489-90.
1980: B Hetnarski; Henryk M Wisniewski; Khalid Iqbal; J D Dziedzic; A Lajtha
Regional distribution of choline acetyltransferase and acetylcholinesterase in rabbit brain.
Neurochemical research 1980;5(4):385-92.
1979: Inge Grundke-Iqbal; A B Johnson; R D Terry; Henryk M Wisniewski; Khalid Iqbal
Alzheimer neurofibrillary tangles: antiserum and immunohistological staining.
Annals of neurology 1979;6(6):532-7.
1979: J R McDermott; A I Smith; Khalid Iqbal; Henryk M Wisniewski
Brain aluminum in aging and Alzheimer disease.
Neurology 1979;29(6):809-14.
1979: Inge Grundke-Iqbal; A B Johnson; Henryk M Wisniewski; R D Terry; Khalid Iqbal
Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.
Lancet 1979;1(8116):578-80.
1979: Robert K Yu; Khalid Iqbal
Sialosylgalactosyl ceramide as a specific marker for human myelin and oligodendroglial perikarya: gangliosides of human myelin, oligodendroglia and neurons.
Journal of neurochemistry 1979;32(2):293-300.
1978: W T Norton; Khalid Iqbal; CAROL TIFFANY; I Tellez-Nagel
Huntington disease: normal lipid composition of purified neuronal perikarya and whole cortex.
Neurology 1978;28(8):812-6.
1978: Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski; R D Terry
Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules.
Brain research 1978;142(2):321-32.
1978: C S Raine; U Traugott; Khalid Iqbal; D S Snyder; S R Cohen; M Farooq; W T Norton
Encephalitogenic properties of purified preparations of bovine oligodendrocytes tested in guinea pigs.
Brain research 1978;142(1):85-96.
1978: H H Goebel; R Heipertz; W Scholz; Khalid Iqbal; I Tellez-Nagel
Juvenile Huntington chorea: clinical, ultrastructural, and biochemical studies.
Neurology 1978;28(1):23-31.
1977: J R McDermott; A I Smith; Khalid Iqbal; Henryk M Wisniewski
Aluminium and Alzheimer's disease.
Lancet 1977;2(8040):710-1.
1977: Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski; R D Terry
On neurofilament and neurotubule proteins from human autopsy tissue.
Journal of neurochemistry 1977;29(3):417-24.
1977: J R McDermott; Khalid Iqbal; Henryk M Wisniewski
The encephalitogenic activity and myelin basic protein content of isolated oligodendroglia.
Journal of neurochemistry 1977;28(5):1081-8.
1977: Khalid Iqbal; Inge Grundke-Iqbal; Henryk M Wisniewski
Oligodendroglia from human autopsied brain: bulk isolation and some chemical properties.
Journal of neurochemistry 1977;28(4):707-16.
1977: C S Raine; Henryk M Wisniewski; Khalid Iqbal; I Grundkeiqbal; W T Norton
Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes.
Brain research 1977;120(2):269-86.
1975: Khalid Iqbal; Henryk M Wisniewski; Inge Grundke-Iqbal; J K Korthals; R D Terry
Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1975;23(7):563-9.
1974: Khalid Iqbal; Henryk M Wisniewski; Michael L. Shelanski; S Brostoff; B H Liwnicz; R D Terry
Protein changes in senile dementia.
Brain research 1974;77(2):337-43.
1974: Khalid Iqbal; I Tellez-Nagel; Inge Grundke-Iqbal
Protein abnormalities in Huntington's chorea.
Brain research 1974;76(1):178-84.
1972: Khalid Iqbal; I Tellez-Nagel
Isolation of neurons and glial cells from normal and pathological human brains.
Brain research 1972;45(1):296-301.
1970: Khalid Iqbal; J H Ottaway
Glutamine synthetase in muscle and kidney.
The Biochemical journal 1970;119(2):145-56.