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Thomas Burghardt

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TOP 3
Yihua Wang; Katalin Ajtai; Thomas P Burghardt
The Qdot-labeled actin super-resolution motility assay measures low-duty cycle muscle myosin step size.
Thomas P Burghardt; Laura A Sikkink
Regulatory light chain mutants linked to heart disease modify the cardiac myosin lever arm.
Thomas P Burghardt; Katalin Ajtai
Cell biology. Heart brakes.

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All Publications

2013: Yihua Wang; Katalin Ajtai; Thomas P Burghardt
The Qdot-labeled actin super-resolution motility assay measures low-duty cycle muscle myosin step size.
Biochemistry 2013;52(9):1611-21.
2013: Thomas P Burghardt; Laura A Sikkink
Regulatory light chain mutants linked to heart disease modify the cardiac myosin lever arm.
Biochemistry 2013;52(7):1249-59.
2012: Thomas P Burghardt; Katalin Ajtai
Cell biology. Heart brakes.
Science (New York, N.Y.) 2012;337(6099):1182-3.
2012: Thomas P Burghardt
Evanescent field shapes excitation profile under axial epi-illumination.
Journal of biomedical optics 2012;17(6):066021.
2011: Thomas P Burghardt
Single molecule fluorescence image patterns linked to dipole orientation and axial position: application to myosin cross-bridges in muscle fibers.
PloS one 2011;6(2):e16772.
2010: Thomas P Burghardt; Kevin L Neff; Eric D Wieben; Katalin Ajtai
Myosin individualized: single nucleotide polymorphisms in energy transduction.
BMC genomics 2010;11():172.
2009: Katalin Ajtai; Miriam F Halstead; Miklós Nyitrai; Alan R Penheiter; Ye Zheng; Thomas P Burghardt
The myosin C-loop is an allosteric actin contact sensor in actomyosin.
Biochemistry 2009;48(23):5263-75.
2009: Thomas P Burghardt; Katalin Ajtai
Mapping microscope object polarized emission to the back focal plane pattern.
Journal of biomedical optics 2009;14(3):034036.
2009: Donkena Krishna Vanaja; Michael E Grossmann; John C Cheville; Mozammel H Gazi; Aiyu Gong; Jin San Zhang; Katalin Ajtai; Thomas P Burghardt; Charles Y F Young
PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.
Cancer investigation 2009;27(3):264-72.
2009: Thomas P Burghardt; Jinhui Li; Katalin Ajtai
Single myosin lever arm orientation in a muscle fiber detected with photoactivatable GFP.
Biochemistry 2009;48(4):754-65.
2007: Thomas P Burghardt; Jimmy Yan Hu; Katalin Ajtai
Myosin dynamics on the millisecond time scale.
Biophysical chemistry 2007;131(1-3):15-28.
2007: Miriam F Halstead; Katalin Ajtai; Alan R Penheiter; Joshua D Spencer; Ye Zheng; Emma A Morrison; Thomas P Burghardt
An unusual transduction pathway in human tonic smooth muscle myosin.
Biophysical journal 2007;93(10):3555-66.
2007: Thomas P Burghardt; Katalin Ajtai; Daniel K Chan; Miriam F Halstead; Jinhui Li; Ye Zheng
GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber.
Biophysical journal 2007;93(6):2226-39.
2007: Julian Borejdo; Priya Muthu; John M Talent; Irina Akopova; Thomas P Burghardt
Rotation of actin monomers during isometric contraction of skeletal muscle.
Journal of biomedical optics 2007;12(1):014013.
2006: Thomas P Burghardt; Jon E Charlesworth; Miriam F Halstead; James E Tarara; Katalin Ajtai
In situ fluorescent protein imaging with metal film-enhanced total internal reflection microscopy.
Biophysical journal 2006;90(12):4662-71.
2006: Thomas P Burghardt; Katalin Ajtai; Julian Borejdo
In situ single-molecule imaging with attoliter detection using objective total internal reflection confocal microscopy.
Biochemistry 2006;45(13):4058-68.
2006: Julian Borejdo; John M Talent; Irina Akopova; Thomas P Burghardt
Rotations of a few cross-bridges in muscle by confocal total internal reflection microscopy.
Biochimica et biophysica acta 2006;1763(2):137-40.
2004: Katalin Ajtai; Susanna P Garamszegi; Shinya Watanabe; Mitsuo Ikebe; Thomas P Burghardt
The myosin cardiac loop participates functionally in the actomyosin interaction.
The Journal of biological chemistry 2004;279(22):23415-21.
2004: Julian Borejdo; AA Shepard; D Dumka; Irina Akopova; John M Talent; A Malka; Thomas P Burghardt
Changes in orientation of actin during contraction of muscle.
Biophysical journal 2004;86(4):2308-17.
2003: Y Michael Peyser; Shirley Shaya; Katalin Ajtai; Thomas P Burghardt; Andras Muhlrad
Cosolvent-induced aggregation inhibits myosin ATPase activity by stabilizing the predominant transition intermediate.
Biochemistry 2003;42(43):12669-75.
2003: Miao He; Thomas P Burghardt; Jerry Vockley
A novel approach to the characterization of substrate specificity in short/branched chain Acyl-CoA dehydrogenase.
The Journal of biological chemistry 2003;278(39):37974-86.
2003: Thomas P Burghardt; Sungjo Park; Wen-Ji Dong; Jun Xing; Herbert C Cheung; Katalin Ajtai
Energy transduction optical sensor in skeletal myosin.
Biochemistry 2003;42(19):5877-84.
2003: Andras Muhlrad; Y Michael Peyser; Mahta Nili; Katalin Ajtai; Emil Reisler; Thomas P Burghardt
Chemical decoupling of ATPase activation and force production from the contractile cycle in myosin by steric hindrance of lever-arm movement.
Biophysical journal 2003;84(2 Pt 1):1047-56.
2003: H Robert Bergen; Katalin Ajtai; Thomas P Burghardt; Angelito I Nepomuceno; David C Muddiman
Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle.
Rapid communications in mass spectrometry : RCM 2003;17(13):1467-71.
2002: Tien V Nguyen; Charles Riggs; Dusica Babovic-Vuksanovic; Yong-Sung Kim; John F Carpenter; Thomas P Burghardt; Niels Gregersen; Jerry Vockley
Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme.
Biochemistry 2002;41(37):11126-33.
2002: Thomas P Burghardt; Nenad Juranić; Slobodan Macura; Katalin Ajtai
Cation-pi interaction in a folded polypeptide.
Biopolymers 2002;63(4):261-72.
2002: Sungjo Park; Thomas P Burghardt
Tyrosine mediated tryptophan ATP sensitivity in skeletal myosin.
Biochemistry 2002;41(5):1436-44.
2001: Katalin Ajtai; Susanna P Garamszegi; Sungjo Park; A L Velazquez Dones; Thomas P Burghardt
Structural characterization of beta-cardiac myosin subfragment 1 in solution.
Biochemistry 2001;40(40):12078-93.
2001: Y Michael Peyser; Katalin Ajtai; Thomas P Burghardt; Andras Muhlrad
Effect of ionic strength on the conformation of myosin subfragment 1-nucleotide complexes.
Biophysical journal 2001;81(2):1101-14.
2001: Thomas P Burghardt; Sungjo Park; Katalin Ajtai
Conformation of myosin interdomain interactions during contraction: deductions from proteins in solution.
Biochemistry 2001;40(15):4834-43.
2001: Thomas P Burghardt; A R Cruz-Walker; Sungjo Park; Katalin Ajtai
Conformation of myosin interdomain interactions during contraction: deductions from muscle fibers using polarized fluorescence.
Biochemistry 2001;40(15):4821-33.
2000: Sungjo Park; Thomas P Burghardt
Isolating and localizing ATP-sensitive tryptophan emission in skeletal myosin subfragment 1.
Biochemistry 2000;39(38):11732-41.
1999: Katalin Ajtai; Y Michael Peyser; Sungjo Park; Thomas P Burghardt; Andras Muhlrad
Trinitrophenylated reactive lysine residue in myosin detects lever arm movement during the consecutive steps of ATP hydrolysis.
Biochemistry 1999;38(20):6428-40.
1999: BF Roettger; Delia I Pinon; Thomas P Burghardt; Laurence J Miller
Regulation of lateral mobility and cellular trafficking of the CCK receptor by a partial agonist.
The American journal of physiology 1999;276(3 Pt 1):C539-47.
1999: Sungjo Park; Katalin Ajtai; Thomas P Burghardt
Inhibition of myosin ATPase by metal fluoride complexes.
Biochimica et biophysica acta 1999;1430(1):127-40.
1998: L Moschcovich; Y Michael Peyser; C Salomon; Thomas P Burghardt; Andras Muhlrad
Interaction of myosin subfragment 1 with two non-nucleotide ATP analogues.
Biochemistry 1998;37(43):15137-43.
1998: B B Bartha; Katalin Ajtai; David O Toft; Thomas P Burghardt
ATP sensitive tryptophans of hsp90.
Biophysical chemistry 1998;72(3):313-21.
1998: Thomas P Burghardt; Susanna P Garamszegi; Sungjo Park; Katalin Ajtai
Tertiary structural changes in the cleft containing the ATP sensitive tryptophan and reactive thiol are consistent with pivoting of the myosin heavy chain at Gly699.
Biochemistry 1998;37(22):8035-47.
1998: Katalin Ajtai; F Dai; Sungjo Park; C R Zayas; Y Michael Peyser; Andras Muhlrad; Thomas P Burghardt
Near UV circular dichroism from biomimetic model compounds define the coordination geometry of vanadate centers in MeVi- and MeADPVi-rabbit myosin subfragment 1 complexes in solution.
Biophysical chemistry 1998;71(2-3):205-20.
1997: Thomas P Burghardt; Susanna P Garamszegi; Katalin Ajtai
Probes bound to myosin Cys-707 rotate during length transients in contraction.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9631-6.
1997: Y Michael Peyser; Katalin Ajtai; M M Werber; Thomas P Burghardt; Andras Muhlrad
Effect of metal cations on the conformation of myosin subfragment-1-ADP-phosphate analog complexes: a near-UV circular dichroism study.
Biochemistry 1997;36(17):5170-8.
1997: Sungjo Park; Katalin Ajtai; Thomas P Burghardt
Mechanism for coupling free energy in ATPase to the myosin active site.
Biochemistry 1997;36(11):3368-72.
1996: Sungjo Park; Katalin Ajtai; Thomas P Burghardt
Optical activity of a nucleotide-sensitive tryptophan in myosin subfragment 1 during ATP hydrolysis.
Biophysical chemistry 1996;63(1):67-80.
1996: Sungjo Park; Katalin Ajtai; Thomas P Burghardt
Cleft containing reactive thiol of myosin closes during ATP hydrolysis.
Biochimica et biophysica acta 1996;1296(1):1-4.
1996: Thomas P Burghardt; Katalin Ajtai
The conformation of xanthene dyes in the myosin sulfhydryl one binding site. Part I. Methods and model systems.
Biophysical chemistry 1996;60(3):119-33.
1996: Thomas P Burghardt; J E Lyke; Katalin Ajtai
Fluorescence emission and anisotropy from rhodamine dimers.
Biophysical chemistry 1996;59(1-2):119-31.
1995: Katalin Ajtai; Thomas P Burghardt
Conformation of xanthene dyes in the sulfhydryl 1 binding site of myosin. 2.
Biochemistry 1995;34(49):15943-52.
1994: Katalin Ajtai; D J Toft; Thomas P Burghardt
Path and extent of cross-bridge rotation during muscle contraction.
Biochemistry 1994;33(18):5382-91.
1994: Thomas P Burghardt; Katalin Ajtai
Following the rotational trajectory of the principal hydrodynamic frame of a protein using multiple probes.
Biochemistry 1994;33(18):5376-81.
1993: Thomas P Burghardt; Katalin Ajtai
Luminescent/paramagnetic probes of order and orientation in biological assemblies: the transformation of luminescent probes into pi-radicals by photochemical reduction within the contractile apparatus.
Advances in experimental medicine and biology 1993;332():225-33.
1992: Katalin Ajtai; P J Ilich; A Ringler; S S Sedarous; D J Toft; Thomas P Burghardt
Stereospecific reaction of muscle fiber proteins with the 5' or 6' isomer of (iodoacetamido)tetramethylrhodamine.
Biochemistry 1992;31(49):12431-40.
1992: Katalin Ajtai; Thomas P Burghardt
Luminescent/paramagnetic probes for detecting order in biological assemblies: transformation of luminescent probes into pi-radicals by photochemical reduction.
Biochemistry 1992;31(17):4275-82.
1992: Katalin Ajtai; A Ringler; Thomas P Burghardt
Probing cross-bridge angular transitions using multiple extrinsic reporter groups.
Biochemistry 1992;31(1):207-17.
1992: Thomas P Burghardt; Katalin Ajtai
Mapping global angular transitions of proteins in assemblies using multiple extrinsic reporter groups.
Biochemistry 1992;31(1):200-6.
1990: Katalin Ajtai; L Pótó; Thomas P Burghardt
Specificity and orientation of (iodoacetamido)proxyl spin-labeled myosin subfragment 1 decorating muscle fibers: localization of protein-bound spin labels using SDS-PAGE.
Biochemistry 1990;29(33):7733-41.
1989: Katalin Ajtai; A R French; Thomas P Burghardt
Myosin cross-bridge orientation in rigor and in the presence of nucleotide studied by electron spin resonance.
Biophysical journal 1989;56(3):535-41.
1989: Thomas P Burghardt; A R French
Reconstruction of the probe angular distribution from a series of electron spin resonance spectra of tilted oriented samples.
Biophysical journal 1989;56(3):525-34.
1989: Thomas P Burghardt; Katalin Ajtai
Effect of negative mechanical stress on the orientation of myosin cross-bridges in muscle fibers.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5366-70.
1989: Katalin Ajtai; Thomas P Burghardt
Fluorescent modification and orientation of myosin sulfhydryl 2 in skeletal muscle fibers.
Biochemistry 1989;28(5):2204-10.
1987: Katalin Ajtai; Thomas P Burghardt
Probe studies of the MgADP state of muscle cross-bridges: microscopic and wavelength-dependent fluorescence polarization from 1,5-IAEDANS-labeled myosin subfragment 1 decorating muscle fibers.
Biochemistry 1987;26(14):4517-23.
1986: Katalin Ajtai; Thomas P Burghardt
Observation of two orientations from rigor cross-bridges in glycerinated muscle fibers.
Biochemistry 1986;25(20):6203-7.
1986: Thomas P Burghardt; Katalin Ajtai
Model-independent time-resolved fluorescence depolarization from ordered biological assemblies applied to restricted motion of myosin cross-bridges in muscle fibers.
Biochemistry 1986;25(11):3469-78.
1986: Andras Muhlrad; A A Kasprzak; K Ue; Katalin Ajtai; Thomas P Burghardt
Characterization of the isolated 20 kDa and 50 kDa fragments of the myosin head.
Biochimica et biophysica acta 1986;869(2):128-40.
1985: Thomas P Burghardt; Katalin Ajtai
Fraction of myosin cross-bridges bound to actin in active muscle fibers: estimation by fluorescence anisotropy measurements.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8478-82.