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Wolfgang Löscher

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Co-Publications
Name
53
Ebert, Ulrich
48
Potschka, Heidrun
42
Richter, Angelika
29
Rundfeldt, Chris
19
Gernert, Manuela
19
Fedrowitz, Maren
18
Mevissen, M
17
Brandt, Claudia
16
Wlaz, Piotr
10
Hoffmann, Katrin
8
Lehmann, H
8
Volk, Holger
6
Reissmüller, E
6
Lindemann, Sven
6
Gastens, Alexandra

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Publications

TOP 3
Löscher Wolfgang
Abnormal circling behavior in rat mutants and its relevance to model specific brain dysfunctions.
Müller Christine J; Bankstahl Marion; Gröticke Ina; Löscher Wolfgang
Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage.
Müller Christine J; Gröticke Ina; Bankstahl Marion; Löscher Wolfgang
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.

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All Publications

2010: Löscher Wolfgang
Abnormal circling behavior in rat mutants and its relevance to model specific brain dysfunctions.
Neuroscience and biobehavioral reviews 2010;34(1):31-49.
2009: Müller Christine J; Bankstahl Marion; Gröticke Ina; Löscher Wolfgang
Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage.
European journal of pharmacology 2009;619(1-3):15-24.
2009: Müller Christine J; Gröticke Ina; Bankstahl Marion; Löscher Wolfgang
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Experimental neurology 2009;219(1):284-97.
2009: Müller C J; Gröticke I; Hoffmann K; Schughart K; Löscher W
Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice.
Genes, brain, and behavior 2009;8(5):481-92.
2009: Matagne Alain; Margineanu Doru-Georg; Potschka Heidrun; Löscher Wolfgang; Michel Philippe; Kenda Benoit; Klitgaard Henrik
Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy.
European journal of pharmacology 2009;614(1-3):30-7.
2009: Löscher Wolfgang; Delanty Norman
MDR1/ABCB1 polymorphisms and multidrug resistance in epilepsy: in and out of fashion.
Pharmacogenomics 2009;10(5):711-3.
2009: Löscher Wolfgang
Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans.
European journal of pharmacology 2009;610(1-3):1-11.
2009: Löscher Wolfgang; Cole Andrew J; McLean Michael J
Commentary: physical approaches for the treatment of epilepsy: electrical and magnetic stimulation and cooling.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(2):258-62.
2009: Hoffmann Katrin; Sivukhina Elena; Potschka Heidrun; Schachner Melitta; Löscher Wolfgang; Dityatev Alexander
Retarded kindling progression in mice deficient in the extracellular matrix glycoprotein tenascin-R.
Epilepsia 2009;50(4):859-69.
2009: Kuteykin-Teplyakov Konstantin; Brandt Claudia; Hoffmann Katrin; Löscher Wolfgang
Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus.
Epilepsia 2009;50(4):887-97.
2009: Schmidt Dieter; Löscher Wolfgang
New developments in antiepileptic drug resistance: an integrative view.
Epilepsy currents / American Epilepsy Society 2009;9(2):47-52.
2009: Löscher Wolfgang; Klotz Ulrich; Zimprich Fritz; Schmidt Dieter
The clinical impact of pharmacogenetics on the treatment of epilepsy.
Epilepsia 2009;50(1):1-23.
2008: Luna-Tortós Carlos; Fedrowitz Maren; Löscher Wolfgang
Several major antiepileptic drugs are substrates for human P-glycoprotein.
Neuropharmacology 2008;55(8):1364-75.
2008: Bankstahl Jens P; Löscher Wolfgang
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Epilepsy research 2008;82(1):70-85.
2008: Hoffmann Katrin; Czapp Marion; Löscher Wolfgang
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?
Epilepsy research 2008;81(2-3):107-13.
2008: Gastens Alexandra M; Brandt Claudia; Bankstahl Jens P; Löscher Wolfgang
Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy.
Epilepsia 2008;49(10):1759-76.
2008: Nolte Marc W; Löscher Wolfgang; Herden Christiane; Freed William J; Gernert Manuela
Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures.
Neurobiology of disease 2008;31(3):342-54.
2008: Gröticke Ina; Hoffmann Katrin; Löscher Wolfgang
Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate.
Experimental neurology 2008;213(1):71-83.
2008: Bankstahl Jens P; Kuntner Claudia; Abrahim Aiman; Karch Rudolf; Stanek Johann; Wanek Thomas; Wadsak Wolfgang; Kletter Kurt; Müller Markus; Löscher Wolfgang; Langer Oliver
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(8):1328-35.
2008: Bethmann Kerstin; Fritschy Jean-Marc; Brandt Claudia; Löscher Wolfgang
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Neurobiology of disease 2008;31(2):169-87.
2008: Bankstahl Jens P; Hoffmann Katrin; Bethmann Kerstin; Löscher W
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain.
Neuropharmacology 2008;54(6):1006-16.
2008: Palomero-Gallagher Nicola; Schleicher Axel; Lindemann Sven; Lessenich Alina; Zilles Karl; Löscher Wolfgang
Receptor fingerprinting the circling ci2 rat mutant: insights into brain asymmetry and motor control.
Experimental neurology 2008;210(2):624-37.
2008: Hoffmann Katrin; Lindner Maren; Gröticke Ina; Stangel Martin; Löscher Wolfgang
Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice.
Experimental neurology 2008;210(2):308-21.
2008: Löscher Wolfgang; Gernert Manuela; Heinemann Uwe
Cell and gene therapies in epilepsy--promising avenues or blind alleys?
Trends in neurosciences 2008;31(2):62-73.
2008: Lindema Sven; Gernet Manuela; Bennay Mustapha; Koch Michael; Löscher Wolfgang
Comparative analysis of anxiety-like behaviors and sensorimotor functions in two rat mutants, ci2 and ci3, with lateralized rotational behavior.
Physiology & behavior 2008;93(1-2):417-26.
2008: Fedrowitz Maren; Löscher Wolfgang
Exposure of Fischer 344 rats to a weak power frequency magnetic field facilitates mammary tumorigenesis in the DMBA model of breast cancer.
Carcinogenesis 2008;29(1):186-93.
2007: Löscher Wolfgang; Sills Graeme J
Drug resistance in epilepsy: why is a simple explanation not enough?
Epilepsia 2007;48(12):2370-2.
2007: Gröticke Ina; Hoffmann Katrin; Löscher Wolfgang
Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice.
Experimental neurology 2007;207(2):329-49.
2007: Brandt Claudia; Glien Maike; Gastens Alexandra M; Fedrowitz Maren; Bethmann Kerstin; Volk Holger A; Potschka Heidrun; Löscher Wolfgang
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats.
Neuropharmacology 2007;53(2):207-21.
2007: Lindemann Sven; Gernert Manuela; Bennay Mustapha; Koch Michael; Löscher Wolfgang
Comparative analysis of anxiety-like behaviors and sensorimotor functions in two rat mutants, ci2 and ci3, with lateralized rotational behavior.
Physiology & behavior 2007;91(5):551-60.
2007: Löscher Wolfgang
The pharmacokinetics of antiepileptic drugs in rats: consequences for maintaining effective drug levels during prolonged drug administration in rat models of epilepsy.
Epilepsia 2007;48(7):1245-58.
2007: Schirmer Marko; Kaiser Alexander; Lessenich Alina; Lindemann Sven; Fedrowitz Maren; Gernert Manuela; Löscher Wolfgang
Auditory and vestibular defects and behavioral alterations after neonatal administration of streptomycin to Lewis rats: Similarities and differences to the circling (ci2/ci2) Lewis rat mutant.
Brain research 2007;1155():179-95.
2007: Schirmer Marko; Lessenich Alina; Lindemann Sven; Löscher Wolfgang
Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior.
Behavioural brain research 2007;180(2):218-25.
2007: Hoffmann Katrin; Löscher Wolfgang
Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats.
Epilepsia 2007;48(4):631-45.
2007: Bethmann Kerstin; Brandt Claudia; Löscher Wolfgang
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Epilepsia 2007;48(4):816-26.
2007: Schirmer M; Nobrega J N; Harrison S J; Löscher W
Alterations in dopamine D3 receptors in the circling (ci3) rat mutant.
Neuroscience 2007;144(4):1462-9.
2007: Baltes Steffen; Gastens Alexandra M; Fedrowitz Maren; Potschka Heidrun; Kaever Volkhard; Löscher Wolfgang
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
Neuropharmacology 2007;52(2):333-46.
2007: Baltes Steffen; Fedrowitz Maren; Tortós Carlos Luna; Potschka Heidrun; Löscher Wolfgang
Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.
The Journal of pharmacology and experimental therapeutics 2007;320(1):331-43.
2007: Löscher Wolfgang
Mechanisms of drug resistance in status epilepticus.
Epilepsia 2007;48 Suppl 8():74-7.
2007: Löscher Wolfgang
Drug transporters in the epileptic brain.
Epilepsia 2007;48 Suppl 1():8-13.
2006: Brandt Claudia; Heile Anna; Potschka Heidrun; Stoehr Thomas; Löscher Wolfgang
Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats.
Epilepsia 2006;47(11):1803-9.
2006: Baars Cordula; Löscher Wolfgang; Leeb Tosso; Becker Albert; Potschka Heidrun
Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy.
European journal of pharmacology 2006;550(1-3):54-61.
2006: Brandt Claudia; Bethmann Kerstin; Gastens Alexandra M; Löscher Wolfgang
The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy.
Neurobiology of disease 2006;24(1):202-11.
2006: Brandt Claudia; Gastens Alexandra M; Sun Mei zhen; Hausknecht Maria; Löscher Wolfgang
Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats.
Neuropharmacology 2006;51(4):789-804.
2006: Freichel C; Potschka H; Ebert U; Brandt C; Löscher W
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Neuroscience 2006;141(4):2177-94.
2006: Löscher Wolfgang; Schmidt Dieter
Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs.
Epilepsia 2006;47(8):1253-84.
2006: Nolte Marc W; Löscher Wolfgang; Gernert Manuela
Pedunculopontine neurons are involved in network changes in the kindling model of temporal lobe epilepsy.
Neurobiology of disease 2006;23(1):206-18.
2006: Löscher Wolfgang; Schmidt Dieter
New Horizons in the development of antiepileptic drugs: Innovative strategies.
Epilepsy research 2006;69(3):183-272.
2006: Löscher Wolfgang; Dekundy Andrzej; Nagel Jens; Danysz Wojciech; Parsons Chris G; Potschka Heidrun
mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy.
Neuropharmacology 2006;50(8):1006-15.
2006: Rambeck Bernhard; Jürgens Uwe H; May Theodor W; Pannek Heinz Wolfgang; Behne Friedrich; Ebner Alois; Gorji Ali; Straub Heidrun; Speckmann Erwin-Josef; Pohlmann-Eden Bernd; Löscher Wolfgang
Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy.
Epilepsia 2006;47(4):681-94.
2006: Pekcec Anton; Löscher Wolfgang; Potschka Heidrun
Neurogenesis in the adult rat piriform cortex.
Neuroreport 2006;17(6):571-4.
2006: Löscher Wolfgang; Schirmer Marko; Freichel Christian; Gernert Manuela
Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study.
Brain research 2006;1083(1):50-60.
2006: Hoffmann Katrin; Gastens Alexandra M; Volk Holger A; Löscher Wolfgang
Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats.
Epilepsy research 2006;69(1):1-14.
2006: Volk Holger A; Arabadzisz Dimitrula; Fritschy Jean-Marc; Brandt Claudia; Bethmann Kerstin; Löscher Wolfgang
Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.
Neurobiology of disease 2006;21(3):633-46.
2006: Löscher Wolfgang; Poulter Michael O; Padjen Ante L
Major targets and mechanisms of antiepileptic drugs and major reasons for failure.
Advances in neurology 2006;97():417-27.
2005: Löscher Wolfgang
Mechanisms of drug resistance.
Epileptic disorders : international epilepsy journal with videotape 2005;7 Suppl 1():S3-9.
2005: Löscher Wolfgang; Potschka Heidrun
Drug resistance in brain diseases and the role of drug efflux transporters.
Nature reviews. Neuroscience 2005;6(8):591-602.
2005: Volk Holger A; Löscher Wolfgang
Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.
Brain : a journal of neurology 2005;128(Pt 6):1358-68.
2005: Löscher Wolfgang; Potschka Heidrun
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases.
Progress in neurobiology 2005;76(1):22-76.
2005: Volk Holger; Potschka Heidrun; Löscher Wolfgang
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(4):517-31.
2005: Löscher Wolfgang; Potschka Heidrun
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):86-98.
2005: Fedrowitz Maren; Löscher Wolfgang
Power frequency magnetic fields increase cell proliferation in the mammary gland of female Fischer 344 rats but not various other rat strains or substrains.
Oncology 2005;69(6):486-98.
2004: Brandt C; Ebert U; Löscher W
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Epilepsy research 2004;62(2-3):135-56.
2004: Brandt Claudia; Volk Holger A; Löscher Wolfgang
Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.
Epilepsia 2004;45(12):1488-97.
2004: Gernert Manuela; Fedrowitz Maren; Wlaz Piotr; Löscher Wolfgang
Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.
The European journal of neuroscience 2004;20(9):2377-86.
2004: Freichel Christian; Ebert Ulrich; Potschka Heidrun; Löscher Wolfgang
Amygdala-kindling does not induce a persistent loss of GABA neurons in the substantia nigra pars reticulata of rats.
Brain research 2004;1025(1-2):203-9.
2004: Löscher Wolfgang; Potschka Heidrun; Rieck Susanne; Tipold Andrea; Rundfeldt Chris
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Epilepsia 2004;45(10):1228-39.
2004: Löscher Wolfgang; Schmidt Dieter
New horizons in the development of antiepileptic drugs: the search for new targets.
Epilepsy research 2004;60(2-3):77-159.
2004: Potschka Heidrun; Volk Holger A; Löscher Wolfgang
Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats.
Neuroreport 2004;15(10):1657-61.
2004: Potschka Heidrun; Baltes Steffen; Löscher Wolfgang
Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats.
Epilepsy research 2004;58(2-3):85-91.
2004: Volk Holger A; Potschka Heidrun; Löscher Wolfgang
Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats.
Epilepsy research 2004;58(1):67-79.
2004: Fedrowitz Maren; Kamino Kenji; Löscher Wolfgang
Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats.
Cancer research 2004;64(1):243-51.
2004: Schwabe K; Ebert U; Löscher W
Bilateral microinjections of vigabatrin in the central piriform cortex retard amygdala kindling in rats.
Neuroscience 2004;129(2):425-9.
2004: Schwabe K; Ebert U; Löscher W
The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model.
Neuroscience 2004;126(3):727-41.
2004: Volk H A; Burkhardt K; Potschka H; Chen J; Becker A; Löscher W
Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.
Neuroscience 2004;123(3):751-9.
2003: Potschka Heidrun; Fedrowitz Maren; Löscher Wolfgang
Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats.
Epilepsia 2003;44(12):1479-86.
2003: Löscher Wolfgang; Brandt Claudia; Ebert Ulrich
Excessive weight gain in rats over extended kindling of the basolateral amygdala.
Neuroreport 2003;14(14):1829-32.
2003: Potschka Heidrun; Fedrowitz Maren; Löscher Wolfgang
Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity.
The Journal of pharmacology and experimental therapeutics 2003;306(1):124-31.
2003: Brandt Claudia; Glien Maike; Potschka Heidrun; Volk Holger; Löscher Wolfgang
Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats.
Epilepsy research 2003;55(1-2):83-103.
2003: Löscher Wolfgang; Potschka Heidrun; Wlaz Piotr; Danysz Wojciech; Parsons Christopher G
Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.
European journal of pharmacology 2003;466(1-2):99-111.
2003: Fedrowitz M; Lindemann S; Löscher W; Gernert M
Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant.
Neuroscience 2003;118(3):867-78.
2003: Brandt C; Potschka H; Löscher W; Ebert U
N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy.
Neuroscience 2003;118(3):727-40.
2002: Potschka H; Krupp E; Ebert U; Gümbel C; Leichtlein C; Lorch B; Pickert A; Kramps S; Young K; Grüne U; Keller A; Welschof M; Vogt G; Xiao B; Worley P F; Löscher W; Hiemisch H
Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis.
The European journal of neuroscience 2002;16(11):2157-65.
2002: Seegers Ulrike; Potschka Heidrun; Löscher Wolfgang
Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy.
Epilepsy research 2002;51(3):257-68.
2002: Seegers Ulrike; Potschka Heidrun; Löscher Wolfgang
Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions.
European journal of pharmacology 2002;451(2):149-55.
2002: Potschka Heidrun; Fedrowitz Maren; Löscher Wolfgang
P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.
Neuroscience letters 2002;327(3):173-6.
2002: Seegers Ulrike; Potschka Heidrun; Löscher Wolfgang
Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats.
Epilepsia 2002;43(7):675-84.
2002: Gernert Manuela; Thompson Kerry W; Löscher Wolfgang; Tobin Allan J
Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats.
Experimental neurology 2002;176(1):183-92.
2002: Löscher Wolfgang
Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy.
Epilepsy research 2002;50(1-2):105-23.
2002: Löscher W; Leppik I E
Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs.
Epilepsy research 2002;50(1-2):17-20.
2002: Löscher Wolfgang; Schmidt Dieter
New horizons in the development of antiepileptic drugs.
Epilepsy research 2002;50(1-2):3-16.
2002: Glien Maike; Brandt Claudia; Potschka Heidrun; Löscher Wolfgang
Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy.
Epilepsia 2002;43(4):350-7.
2002: Löscher Wolfgang; Potschka Heidrun
Role of multidrug transporters in pharmacoresistance to antiepileptic drugs.
The Journal of pharmacology and experimental therapeutics 2002;301(1):7-14.
2002: Siep E; Richter A; Löscher W; Speckmann E-J; Köhling R
Sodium currents in striatal neurons from dystonic dt(sz) hamsters: altered response to lamotrigine.
Neurobiology of disease 2002;9(2):258-68.
2002: Fedrowitz Maren; Westermann Jürgen; Löscher Wolfgang
Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague Dawley rats.
Cancer research 2002;62(5):1356-63.
2002: Potschka Heidrun; Löscher Wolfgang
A comparison of extracellular levels of phenytoin in amygdala and hippocampus of kindled and non-kindled rats.
Neuroreport 2002;13(1):167-71.
2002: Jeub M; Beck H; Siep E; Rüschenschmidt C; Speckmann E-J; Ebert U; Potschka H; Freichel C; Reissmüller E; Löscher W
Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats.
Neuropharmacology 2002;42(1):107-16.
2002: Löscher Wolfgang
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
CNS drugs 2002;16(10):669-94.
2002: Ebert Ulrich; Brandt Claudia; Löscher Wolfgang
Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat.
Epilepsia 2002;43 Suppl 5():86-95.
2002: Löscher Wolfgang
Animal models of drug-resistant epilepsy.
Novartis Foundation symposium 2002;243():149-59; discussion 159-66, 180-5.
2002: Richter Angelika; Löscher Wolfgang
Animal models of paroxysmal dystonia.
Advances in neurology 2002;89():443-51.
2001: Löscher W
Do cocarcinogenic effects of ELF electromagnetic fields require repeated long-term interaction with carcinogens? Characteristics of positive studies using the DMBA breast cancer model in rats.
Bioelectromagnetics 2001;22(8):603-14.
2001: Lindemann S; Lessenich A; Ebert U; Löscher W
Spontaneous paroxysmal circling behavior in the ci2 rat mutant: epilepsy with rotational seizures or hyperkinetic movement disorder?
Experimental neurology 2001;172(2):437-45.
2001: Gernert M; Löscher W
Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats.
European journal of pharmacology 2001;432(1):35-41.
2001: Potschka H; Fedrowitz M; Löscher W
P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain.
Neuroreport 2001;12(16):3557-60.
2001: Potschka H; Löscher W
In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats.
Epilepsia 2001;42(10):1231-40.
2001: Kaiser A; Fedrowitz M; Ebert U; Zimmermann E; Hedrich H J; Wedekind D; Löscher W
Auditory and vestibular defects in the circling (ci2) rat mutant.
The European journal of neuroscience 2001;14(7):1129-42.
2001: Potschka H; Löscher W
Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain.
Neuroreport 2001;12(11):2387-9.
2001: Glien M; Brandt C; Potschka H; Voigt H; Ebert U; Löscher W
Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy.
Epilepsy research 2001;46(2):111-9.
2001: Redecker P; Pabst H; Löscher W; Steinlechner S
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.
Neuroscience letters 2001;299(1-2):93-6.
2001: Lessenich A; Lindemann S; Richter A; Hedrich H J; Wedekind D; Kaiser A; Löscher W
A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions.
Neuroscience 2001;107(4):615-28.
2000: Ebert U; Wlaz P; Löscher W
High susceptibility of the anterior and posterior piriform cortex to induction of convulsions by bicuculline.
The European journal of neuroscience 2000;12(12):4195-205.
2000: Löscher W; Hönack D
Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam.
Epilepsia 2000;41(12):1499-506.
2000: Richter A; Löschmann P A; Löscher W
Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia.
British journal of pharmacology 2000;131(5):921-6.
2000: Schwabe K; Ebert U; Löscher W
Effects of lesions of the perirhinal cortex on amygdala kindling in rats.
Epilepsy research 2000;42(1):33-41.
2000: Richter A; Löscher W
Animal models of dystonia.
Functional neurology 2000;15(4):259-67.
2000: Gernert M; Hamann M; Bennay M; Löscher W; Richter A
Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):7052-8.
2000: Potschka H; Friderichs E; Löscher W
Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.
British journal of pharmacology 2000;131(2):203-12.
2000: Ebert U; Reissmüller E; Löscher W
The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats.
Neuropharmacology 2000;39(10):1893-903.
2000: Ebert U; Löscher W
Strong olfactory stimulation reduces seizure susceptibility in amygdala-kindled rats.
Neuroscience letters 2000;287(3):199-202.
2000: Richter A; Löscher W
Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.
European journal of pharmacology 2000;397(2-3):343-50.
2000: Löscher W; Reissmüller E; Ebert U
Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats.
Epilepsy research 2000;40(1):63-77.
2000: Löscher W; Fiedler M
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Epilepsia 2000;41(5):516-28.
2000: Löscher W; Reissmüller E; Ebert U
Kindling alters the anticonvulsant efficacy of phenytoin in Wistar rats.
Epilepsy research 2000;39(3):211-20.
2000: Reissmüller E; Ebert U; Löscher W
Anticonvulsant efficacy of topiramate in phenytoin-resistant kindled rats.
Epilepsia 2000;41(4):372-9.
2000: Löscher W; Richter A
Piracetam and levetiracetam, two pyrrolidone derivatives, exert antidystonic activity in a hamster model of paroxysmal dystonia.
European journal of pharmacology 2000;391(3):251-4.
2000: Potschka H; Feuerstein T J; Löscher W
Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(2):200-5.
2000: Potschka H; Schwabe K; Löscher W
Development of kindling and spontaneous seizures after massed stimulation of different loci in the rat piriform cortex.
Brain research 2000;855(2):252-9.
2000: Löscher W; Fiedler M
The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures.
Epilepsy research 2000;38(2-3):231-48.
2000: Schwabe K; Ebert U; Löscher W
Bilateral lesions of the central but not anterior or posterior parts of the piriform cortex retard amygdala kindling in rats.
Neuroscience 2000;101(3):513-21.
2000: Gernert M; Bloms-Funke P; Ebert U; Löscher W
Kindling causes persistent in vivo changes in firing rates and glutamate sensitivity of central piriform cortex neurons in rats.
Neuroscience 2000;99(2):217-27.
2000: Rehders J H; Löscher W; Richter A
Evidence for striatal dopaminergic overactivity in paroxysmal dystonia indicated by microinjections in a genetic rodent model.
Neuroscience 2000;97(2):267-77.
2000: Fedrowitz M; Potschka H; Richter A; Löscher W
A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior.
Neuroscience 2000;97(1):69-77.
1999: Potschka H; Löscher W
Corneal kindling in mice: behavioral and pharmacological differences to conventional kindling.
Epilepsy research 1999;37(2):109-20.
1999: Löscher W; Hönack D; Gramer M
Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions.
Epilepsy research 1999;37(2):95-108.
1999: Thun-Battersby S; Westermann J; Löscher W
Lymphocyte subset analyses in blood, spleen and lymph nodes of female Sprague-Dawley rats after short or prolonged exposure to a 50 Hz 100-microT magnetic field.
Radiation research 1999;152(4):436-43.
1999: Gernert M; Richter A; Löscher W
In vivo extracellular electrophysiology of pallidal neurons in dystonic and nondystonic hamsters.
Journal of neuroscience research 1999;57(6):894-905.
1999: Mevissen M; Häussler M; Löscher W
Alterations in ornithine decarboxylase activity in the rat mammary gland after different periods of 50 Hz magnetic field exposure.
Bioelectromagnetics 1999;20(6):338-46.
1999: Gernert M; Richter A; Löscher W
Subconvulsive dose of pentylenetetrazole increases the firing rate of substantia nigra pars reticulata neurons in dystonic but not in nondystonic hamsters.
Synapse (New York, N.Y.) 1999;33(4):259-67.
1999: Thun-Battersby S; Mevissen M; Löscher W
Exposure of Sprague-Dawley rats to a 50-Hertz, 100-microTesla magnetic field for 27 weeks facilitates mammary tumorigenesis in the 7,12-dimethylbenz[a]-anthracene model of breast cancer.
Cancer research 1999;59(15):3627-33.
1999: Potschka H; Fedrowitz M; Löscher W
Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats.
European journal of pharmacology 1999;374(2):175-87.
1999: Löscher W
Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action.
Progress in neurobiology 1999;58(1):31-59.
1999: Richter A; Löscher W
Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis.
European journal of pharmacology 1999;369(3):335-8.
1999: Bloms-Funke P; Gernert M; Ebert U; Löscher W
Extracellular single-unit recordings of piriform cortex neurons in rats: influence of different types of anesthesia and characterization of neurons by pharmacological manipulation of serotonin receptors.
Journal of neuroscience research 1999;55(5):608-19.
1999: Richter A; Ebert U; Nobrega J N; Vallbacka J J; Fedrowitz M; Löscher W
Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior.
Neuroscience 1999;89(2):461-71.
1999: Gernert M; Richter A; Löscher W
Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters.
Brain research 1999;821(2):277-85.
1999: Löscher W; Lehmann H; Teschendorf H J; Traut M; Gross G
Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy.
The Journal of pharmacology and experimental therapeutics 1999;288(3):984-92.
1999: Wlaz P; Ebert U; Löscher W
Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats.
Neuropharmacology 1999;38(2):243-51.
1999: Ebert U; Löscher W
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of genetic factors.
Epilepsy research 1999;33(2-3):217-26.
1999: Ebert U; Rundfeldt C; Lehmann H; Löscher W
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: influence of experimental and environmental factors.
Epilepsy research 1999;33(2-3):199-215.
1999: Löscher W; Lehmann H; Behl B; Seemann D; Teschendorf H J; Hofmann H P; Lubisch W; Höger T; Lemaire H G; Gross G
A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy.
The European journal of neuroscience 1999;11(1):250-62.
1999: Häussler M; Thun-Battersby S; Mevissen M; Löscher W
Exposure of rats to a 50-Hz, 100 muTesla magnetic field does not affect the ex vivo production of interleukins by activated T or B lymphocytes.
Bioelectromagnetics 1999;20(5):295-305.
1998: Löscher W; Lehmann H
Anticonvulsant efficacy of L-deprenyl (selegiline) during chronic treatment in mice: continuous versus discontinuous administration.
Neuropharmacology 1998;37(12):1587-93.
1998: Löscher W; Cramer S; Ebert U
Differences in kindling development in seven outbred and inbred rat strains.
Experimental neurology 1998;154(2):551-9.
1998: Potschka H; Löscher W; Wlaz P; Behl B; Hofmann H P; Treiber H J; Szabo L
LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.
British journal of pharmacology 1998;125(6):1258-66.
1998: Potschka H; Thun-Battersby S; Löscher W
Effect of low-intensity 50-Hz magnetic fields on kindling acquisition and fully kindled seizures in rats.
Brain research 1998;809(2):269-76.
1998: Löscher W; Cramer S; Ebert U
Selection of phenytoin responders and nonresponders in male and female amygdala-kindled Sprague-Dawley rats.
Epilepsia 1998;39(11):1138-47.
1998: Löscher W; Mevissen M; Lerchl A
Exposure of female rats to a 100-microT 50 Hz magnetic field does not induce consistent changes in nocturnal levels of melatonin.
Radiation research 1998;150(5):557-67.
1998: Cramer S; Ebert U; Löscher W
Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: comparison of inbred strains.
Epilepsia 1998;39(10):1046-53.
1998: Löscher W; Cramer S; Ebert U
Limbic epileptogenesis alters the anticonvulsant efficacy of phenytoin in Sprague-Dawley rats.
Epilepsy research 1998;31(3):175-86.
1998: Lehmann H; Ebert U; Löscher W
Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex.
Synapse (New York, N.Y.) 1998;29(4):299-309.
1998: Wlaz P; Ebert U; Potschka H; Löscher W
Electrical but not chemical kindling increases sensitivity to some phencyclidine-like behavioral effects induced by the competitive NMDA receptor antagonist D-CPPene in rats.
European journal of pharmacology 1998;353(2-3):177-89.
1998: Richter A; Brotchie J M; Crossman A R; Löscher W
[3H]-2-deoxyglucose uptake study in mutant dystonic hamsters: abnormalities in discrete brain regions of the motor system.
Movement disorders : official journal of the Movement Disorder Society 1998;13(4):718-25.
1998: Löscher W; Lehmann H; Ebert U
Differences in the distribution of GABA- and GAD-immunoreactive neurons in the anterior and posterior piriform cortex of rats.
Brain research 1998;800(1):21-31.
1998: Krupp E; Löscher W
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1137-49.
1998: Wláz P; Potschka H; Löscher W
Frontal versus transcorneal stimulation to induce maximal electroshock seizures or kindling in mice and rats.
Epilepsy research 1998;30(3):219-29.
1998: Gernert M; Richter A; Rundfeldt C; Löscher W
Quantitative EEG analysis of depth electrode recordings from several brain regions of mutant hamsters with paroxysmal dystonia discloses frequency changes in the basal ganglia.
Movement disorders : official journal of the Movement Disorder Society 1998;13(3):509-21.
1998: Löscher W; Liburdy R P
Animal and cellular studies on carcinogenic effects of low frequency (50/60-Hz) magnetic fields.
Mutation research 1998;410(2):185-220.
1998: Löscher W
Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy.
Progress in neurobiology 1998;54(6):721-41.
1998: Richter A; Löscher W
Pathology of idiopathic dystonia: findings from genetic animal models.
Progress in neurobiology 1998;54(6):633-77.
1998: Löscher W; Reissmüller E; Ebert U
Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin.
Epilepsy research 1998;30(1):69-76.
1998: Mevissen M; Häussler M; Lerchl A; Löscher W
Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: replication study.
Journal of toxicology and environmental health. Part A 1998;53(5):401-18.
1998: Löscher W; Hönack D; Rundfeldt C
Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy.
The Journal of pharmacology and experimental therapeutics 1998;284(2):474-9.
1998: Wlaz P; Löscher W
Weak anticonvulsant effects of two novel glycineB receptor antagonists in the amygdala-kindling model in rats.
European journal of pharmacology 1998;342(1):39-46.
1998: Löscher W
New visions in the pharmacology of anticonvulsion.
European journal of pharmacology 1998;342(1):1-13.
1998: Löscher W; Wlaz P; Szabo L
Focal ischemia enhances the adverse effect potential of N-methyl-D-aspartate receptor antagonists in rats.
Neuroscience letters 1998;240(1):33-6.
1998: Löscher W; Ebert U; Lehmann H; Rosenthal C; Nikkhah G
Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.
Journal of neuroscience research 1998;51(2):196-209.
1998: Mevissen M; Häussler M; Szamel M; Emmendörffer A; Thun-Battersby S; Löscher W
Complex effects of long-term 50 Hz magnetic field exposure in vivo on immune functions in female Sprague-Dawley rats depend on duration of exposure.
Bioelectromagnetics 1998;19(4):259-70.
1997: Löscher W; Mevissen M; Häussler B
Seasonal influence on 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats under controlled laboratory conditions.
Pharmacology & toxicology 1997;81(6):265-70.
1997: Wlaz P; Löscher W
Anticonvulsant activity of felbamate in amygdala kindling model of temporal lobe epilepsy in rats.
Epilepsia 1997;38(11):1167-72.
1997: Löscher W
Animal models of intractable epilepsy.
Progress in neurobiology 1997;53(2):239-58.
1997: Richter A; Löscher W
MK-801 potentiates antidystonic effects of clozapine but not of haloperidol in mutant dystonic hamsters.
Brain research 1997;769(2):296-302.
1997: Ebert U; Cramer S; Löscher W
Phenytoin's effect on the spread of seizure activity in the amygdala kindling model.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(3):341-7.
1997: Richter A; Gernert M; Löscher W
Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?
European journal of pharmacology 1997;332(2):133-41.
1997: Rohlfs A; Nikkhah G; Rosenthal C; Rundfeldt C; Brandis A; Samii M; Löscher W
Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following a unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway.
Brain research 1997;761(2):352-6.
1997: Gernert M; Richter A; Löscher W
The electrical activity is impaired in the red nucleus of dt(sz) mutant hamsters with paroxysmal dystonia: an EEG power spectrum analysis of depth electrode recordings.
Brain research 1997;760(1-2):102-8.
1997: Ebert U; Wlaz P; Löscher W
Anticonvulsant effects by combined treatment with a glycineB receptor antagonist and a polyamine site antagonist in amygdala-kindled rats.
European journal of pharmacology 1997;322(2-3):179-84.
1997: Richter A; Löscher W
Dextrorphan, but not dextromethorphan, exerts weak antidystonic effects in mutant dystonic hamsters.
Brain research 1997;745(1-2):336-8.
1997: Löscher W; Hönack D
Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus.
Epilepsia 1997;38(1):106-13.
1996: Löscher W; Ebert U
The role of the piriform cortex in kindling.
Progress in neurobiology 1996;50(5-6):427-81.
1996: Bloms-Funke P; Löscher W
The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reticulata neurons.
European journal of pharmacology 1996;316(2-3):211-8.
1996: Richter A; Scholz J; Löscher W; Tonner P H; Wappler F
Effects of the 5-HT2 receptor antagonist ritanserin on halothane-induced increase of inositol phosphates in porcine malignant hyperthermia.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(5):593-7.
1996: Löscher W; Rundfeldt C; Hönack D; Ebert U
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. II. The novel imidazoquinazolines NNC 14-0185 and NNC 14-0189.
The Journal of pharmacology and experimental therapeutics 1996;279(2):573-81.
1996: Löscher W; Rundfeldt C; Hönack D; Ebert U
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
The Journal of pharmacology and experimental therapeutics 1996;279(2):561-72.
1996: Löscher W; Hönack D; Bloms-Funke P
The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata.
Brain research 1996;735(2):208-16.
1996: Löscher W; Richter A; Nikkhah G; Rosenthal C; Ebert U; Hedrich H J
Behavioral and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder.
Neuroscience 1996;74(4):1135-42.
1996: Löscher W; Fiedler M
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds.
Epilepsy research 1996;25(1):3-10.
1996: Ebert U; Gernert M; Löscher W; Richter A
Abnormal c-fos expression in the lateral habenula during dystonic attacks in a hamster model of idiopathic dystonia.
Brain research 1996;728(1):125-9.
1996: Löscher W; Ebert U; Lehmann H
Kindling induces a lasting, regionally selective increase of kynurenic acid in the nucleus accumbens.
Brain research 1996;725(2):252-6.
1996: Lehmann H; Ebert U; Löscher W
Immunocytochemical localization of GABA immunoreactivity in dentate granule cells of normal and kindled rats.
Neuroscience letters 1996;212(1):41-4.
1996: Löscher W; Lehmann H
L-deprenyl (selegiline) exerts anticonvulsant effects against different seizure types in mice.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1410-7.
1996: Rohlfs A; Rundfeldt C; Koch R; Löscher W
A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1305-14.
1996: Mevissen M; Lerchl A; Löscher W
Study on pineal function and DMBA-induced breast cancer formation in rats during exposure to a 100-mG, 50 Hz magnetic field.
Journal of toxicology and environmental health 1996;48(2):169-85.
1996: Mevissen M; Lerchl A; Szamel M; Löscher W
Exposure of DMBA-treated female rats in a 50-Hz, 50 microTesla magnetic field: effects on mammary tumor growth, melatonin levels, and T lymphocyte activation.
Carcinogenesis 1996;17(5):903-10.
1996: Richter A; Löscher W
Antidystonic effects of L-type Ca2+ channel antagonists in a hamster model of idiopathic dystonia.
European journal of pharmacology 1996;300(3):197-202.
1996: Löscher W; Hönack D
Valproate and its major metabolite E-2-en-valproate induce different effects on behaviour and brain monoamine metabolism in rats.
European journal of pharmacology 1996;299(1-3):61-7.
1996: Löscher W; Wauquier A
Use of animal models in developing guiding principles for polypharmacy in epilepsy.
Epilepsy research. Supplement 1996;11():61-5.
1996: Löscher W; Ebert U
Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy.
Epilepsy research. Supplement 1996;11():17-43.
1996: Baran H; Gramer M; Hönack D; Löscher W
Systemic administration of kainate induces marked increases of endogenous kynurenate in various brain regions and plasma of rats.
Advances in experimental medicine and biology 1996;398():265-6.
1995: Löscher W; Rohlfs A; Rundfeldt C
Reduction in firing rate of substantia nigra pars reticulata neurons by valproate: influence of different types of anesthesia in rats.
Brain research 1995;702(1-2):133-44.
1995: Richter A; Löscher W
Behavioural response to pharmacologic manipulation of serotonin receptors in the genetically dystonic hamster.
Pharmacology, biochemistry, and behavior 1995;52(4):655-65.
1995: Baran H; Gramer M; Hönack D; Löscher W
Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats.
European journal of pharmacology 1995;286(2):167-75.
1995: Rundfeldt C; Wlaz P; Hönack D; Löscher W
Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil.
The Journal of pharmacology and experimental therapeutics 1995;275(2):693-702.
1995: Löscher W; Wahnschaffe U; Hönack D; Rundfeldt C
Does prolonged implantation of depth electrodes predispose the brain to kindling?
Brain research 1995;697(1-2):197-204.
1995: Tonner P H; Scholz J; Richter A; Löscher W; Steinfath M; Wappler F; Wlaz P; Hadji B; Roewer N; Schulte am Esch J
Alterations of inositol polyphosphates in skeletal muscle during porcine malignant hyperthermia.
British journal of anaesthesia 1995;75(4):467-71.
1995: Löscher W; Hönack D
Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats.
Epilepsia 1995;36(9):929-37.
1995: Löscher W; Mevissen M
Linear relationship between flux density and tumor co-promoting effect of prolonged magnetic field exposure in a breast cancer model.
Cancer letters 1995;96(2):175-80.
1995: Hönack D; Löscher W
Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs.
Epilepsia 1995;36(8):763-71.
1995: Richter A; Wissel J; Harlizius B; Simon D; Schelosky L; Scholz U; Poewe W; Löscher W
The "campus syndrome" in pigs: neurological, neurophysiological, and neuropharmacological characterization of a new genetic animal model of high-frequency tremor.
Experimental neurology 1995;134(2):205-13.
1995: Löscher W; Hönack D
Anticonvulsant and antiepileptogenic effect of L-deprenyl (selegiline) in the kindling model of epilepsy.
The Journal of pharmacology and experimental therapeutics 1995;274(1):307-14.
1995: Ebert U; Löscher W
Differences in mossy fibre sprouting during conventional and rapid amygdala kindling of the rat.
Neuroscience letters 1995;190(3):199-202.
1995: Löscher W; Ebert U; Wahnschaffe U; Rundfeldt C
Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: comparison with the basolateral amygdala and "area tempestas".
Neuroscience 1995;66(2):265-76.
1995: Mevissen M; Kietzmann M; Löscher W
In vivo exposure of rats to a weak alternating magnetic field increases ornithine decarboxylase activity in the mammary gland by a similar extent as the carcinogen DMBA.
Cancer letters 1995;90(2):207-14.
1995: Ebert U; Rundfeldt C; Löscher W
Development and pharmacological suppression of secondary afterdischarges in the hippocampus of amygdala-kindled rats.
The European journal of neuroscience 1995;7(4):732-41.
1995: Löscher W; Hönack D; Richter A; Schulz H U; Schürer M; Düsing R; Brewster M E
New injectable aqueous carbamazepine solution through complexing with 2-hydroxypropyl-beta-cyclodextrin: tolerability and pharmacokinetics after intravenous injection in comparison to a glycofurol-based formulation.
Epilepsia 1995;36(3):255-61.
1995: Ebert U; Löscher W
Strong induction of c-fos in the piriform cortex during focal seizures evoked from different limbic brain sites.
Brain research 1995;671(2):338-44.
1995: Rundfeldt C; Koch R; Richter A; Mevissen M; Gerecke U; Löscher W
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
European journal of pharmacology 1995;274(1-3):73-81.
1995: Löscher W; Blanke T; Richter A; Hoppen H O
Gonadal sex hormones and dystonia: experimental studies in genetically dystonic hamsters.
Movement disorders : official journal of the Movement Disorder Society 1995;10(1):92-102.
1995: Baran H; Gramer M; Löscher W
Alterations in plasma and brain amino acids after administration of the glycine/NMDA receptor partial agonist, D-cycloserine, to mice and rats.
European journal of pharmacology 1995;273(1-2):197-201.
1994: Löscher W; Hönack D
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
British journal of pharmacology 1994;113(4):1349-57.
1994: Wlaz P; Ebert U; Löscher W
Low doses of the glycine/NMDA receptor antagonist R-(+)-HA-966 but not D-cycloserine induce paroxysmal activity in limbic brain regions of kindled rats.
The European journal of neuroscience 1994;6(11):1710-9.
1994: Richter A; Löscher W
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.
European journal of pharmacology 1994;264(3):371-7.
1994: Richter A; Löschmann P A; Löscher W
The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia.
European journal of pharmacology 1994;264(3):345-51.
1994: Löscher W; Gerdes C; Richter A
Lack of prophylactic or therapeutic efficacy of 5-HT2A receptor antagonists in halothane-induced porcine malignant hyperthermia.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(4):365-74.
1994: Mevissen M; Buntenkötter S; Löscher W
Effects of static and time-varying (50-Hz) magnetic fields on reproduction and fetal development in rats.
Teratology 1994;50(3):229-37.
1994: Löscher W; Annies R; Richter A
Marked regional disturbances in brain metabolism of monoaminergic neurotransmitters in the genetically dystonic hamster.
Brain research 1994;658(1-2):199-208.
1994: Rundfeldt C; Wlaz P; Löscher W
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Brain research 1994;653(1-2):125-30.
1994: Baran H; Löscher W; Mevissen M
The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam.
Brain research 1994;652(2):195-200.
1994: Löscher W; Hönack D
Over-additive anticonvulsant effect of memantine and NBQX in kindled rats.
European journal of pharmacology 1994;259(2):R3-5.
1994: Löscher W; Wahnschaffe U; Mevissen M; Lerchl A; Stamm A
Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats.
Oncology 1994;51(3):288-95.
1994: Wlaz P; Baran H; Löscher W
Effect of the glycine/NMDA receptor partial agonist, D-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice.
European journal of pharmacology 1994;257(3):217-25.
1994: Löscher W; Wlaz P; Rundfeldt C; Baran H; Hönack D
Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.
British journal of pharmacology 1994;112(1):97-106.
1994: Löscher W; Richter A
The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model.
European journal of pharmacology 1994;255(1-3):235-8.
1994: Löscher W; Hörstermann D
Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(3):270-8.
1994: Ebert U; Rundfeldt C; Löscher W
Sex differences in the anticonvulsant efficacy of phenytoin in amygdala-kindled rats.
Brain research 1994;638(1-2):45-52.
1994: Löscher W; Schmidt D
Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?
Epilepsy research 1994;17(2):95-134.
1993: Löscher W; Wahnschaffe U; Hönack D; Drews E; Nau H
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. III. Influence of fasting.
Epilepsy research 1993;16(3):183-94.
1993: Löscher W; Rundfeldt C; Hönack D
Low doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsy.
The European journal of neuroscience 1993;5(11):1545-50.
1993: Richter A; Löscher W
The atypical neuroleptic, clozapine, exerts antidystonic activity in a mutant hamster model. Comparison with haloperidol.
European journal of pharmacology 1993;242(3):309-12.
1993: Wlaz P; Löscher W
The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. V. Lack of seasonal influences on amygdala kindling in rats.
Epilepsy research 1993;16(2):131-6.
1993: Löscher W
In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats.
Neuroscience letters 1993;160(2):177-80.
1993: Löscher W; Annies R; Hönack D
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
European journal of pharmacology 1993;242(3):263-74.
1993: Löscher W; Hönack D
Effects of the novel 5-HT1A receptor antagonist, (+)-WAY 100135, on stereotyped behaviour induced by the NMDA receptor antagonist dizocilpine in rats.
European journal of pharmacology 1993;242(1):99-104.
1993: Hönack D; Löscher W
Sex differences in NMDA receptor mediated responses in rats.
Brain research 1993;620(1):167-70.
1993: Löscher W; Marquardt H
[Are results from animal experiments applicable to humans?]
Deutsche medizinische Wochenschrift (1946) 1993;118(34-35):1254-63.
1993: Löscher W; Richter A
The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia.
European journal of pharmacology 1993;239(1-3):245-7.
1993: Löscher W; Hönack D
Differences in anticonvulsant potency and adverse effects between dextromethorphan and dextrorphan in amygdala-kindled and non-kindled rats.
European journal of pharmacology 1993;238(2-3):191-200.
1993: Löscher W; Mevissen M; Lehmacher W; Stamm A
Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field.
Cancer letters 1993;71(1-3):75-81.
1993: Wahnschaffe U; Ebert U; Löscher W
The effects of lesions of the posterior piriform cortex on amygdala kindling in the rat.
Brain research 1993;615(2):295-303.
1993: Rundfeldt C; Löscher W
Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats.
The Journal of pharmacology and experimental therapeutics 1993;266(1):216-23.
1993: Löscher W; Rundfeldt C; Hönack D
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Epilepsy research 1993;15(3):207-19.
1993: Löscher W; Hörstermann D; Hönack D; Rundfeldt C; Wahnschaffe U
Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.
Neurochemical research 1993;18(7):775-81.
1993: Löscher W; Nau H; Wahnschaffe U; Hönack D; Rundfeldt C; Wittfoht W; Bojic U
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. II. Influence of phenobarbital comedication.
Epilepsy research 1993;15(2):113-31.
1993: Richter A; Löscher W
The kappa-opioid receptor agonist, U50,488H, exerts antidystonic activity in a mutant hamster model of generalized dystonia.
European journal of pharmacology 1993;236(2):289-94.
1993: Zwingelberg R; Obe G; Rosenthal M; Mevissen M; Buntenkötter S; Löscher W
Exposure of rats to a 50-Hz, 30-mT magnetic field influences neither the frequencies of sister-chromatid exchanges nor proliferation characteristics of cultured peripheral lymphocytes.
Mutation research 1993;302(1):39-44.
1993: Löscher W; Richter A
[Homeopathy in veterinary medicine and its pharmacologic/toxicologic and drug regulatory evaluation]
Berliner und Münchener tierärztliche Wochenschrift 1993;106(4):109-18.
1993: Löscher W; Hönack D
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
European journal of pharmacology 1993;234(2-3):237-45.
1993: Löscher W
Basic aspects of epilepsy.
Current opinion in neurology and neurosurgery 1993;6(2):223-32.
1993: Löscher W
Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain.
Neurochemical research 1993;18(4):485-502.
1993: Löscher W; Fassbender C P; Gram L; Gramer M; Hörstermann D; Zahner B; Stefan H
Determination of GABA and vigabatrin in human plasma by a rapid and simple HPLC method: correlation between clinical response to vigabatrin and increase in plasma GABA.
Epilepsy research 1993;14(3):245-55.
1993: Löscher W; Hönack D
Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats.
European journal of pharmacology 1993;232(2-3):147-58.
1993: Richter A; Löscher W; Löschmann P A
The AMPA receptor antagonist NBQX exerts antidystonic effects in an animal model of idiopathic dystonia.
European journal of pharmacology 1993;231(2):287-91.
1993: Richter A; Löscher W
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
European journal of pharmacology 1993;231(1):111-9.
1993: Mevissen M; Stamm A; Buntenkötter S; Zwingelberg R; Wahnschaffe U; Löscher W
Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)anthracene in rats.
Bioelectromagnetics 1993;14(2):131-43.
1993: Löscher W
Abecarnil shows reduced tolerance development and dependence potential in comparison to diazepam: animal studies.
Psychopharmacology series 1993;11():96-112.
1992: Hönack D; Löscher W
Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin.
Epilepsy research 1992;13(3):215-21.
1992: Wahnschaffe U; Löscher W
Lack of changes in seizure susceptibility during the estrous cycle in kindled rats.
Epilepsy research 1992;13(3):199-204.
1992: Löscher W; Wahnschaffe U; Hönack D; Wittfoht W; Nau H
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. I. Biochemical, histopathological and pharmacokinetic studies.
Epilepsy research 1992;13(3):187-98.
1992: Dziki M; Hönack D; Löscher W
Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate.
European journal of pharmacology 1992;222(2-3):273-8.
1992: Löscher W; Wahnschaffe U; Rundfeldt C; Hönack D; Hoppen H O
Regional alterations in brain amino acids during the estrous cycle of the rat.
Neurochemical research 1992;17(10):973-7.
1992: Richter A; Gerdes C; Löscher W
Atypical reactions to halothane in a subgroup of homozygous malignant hyperthermia(MH)-susceptible pigs: indication of a heterogenous genetic basis for the porcine syndrome.
DTW. Deutsche tierärztliche Wochenschrift 1992;99(10):401-6.
1992: Gerdes C; Richter A; Annies R; Löscher W
Increase of serotonin in plasma during onset of halothane-induced malignant hyperthermia in pigs.
European journal of pharmacology 1992;220(1):91-4.
1992: Löscher W; Hörstermann D
Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters.
Journal of neurochemistry 1992;59(2):689-94.
1992: Löscher W
Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals.
Pharmaceutisch weekblad. Scientific edition 1992;14(3A):139-43.
1992: Löscher W; Hönack D
The behavioural effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems.
European journal of pharmacology 1992;215(2-3):199-208.
1992: Löscher W; Hönack D
Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(4):452-60.
1992: Rundfeldt C; Löscher W
Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats.
European journal of pharmacology 1992;213(3):351-66.
1992: Löscher W
[Homeopathy: an effective and risk-free alternative to conventional chemotherapy? 2. Detection of effectiveness in animals]
DTW. Deutsche tierärztliche Wochenschrift 1992;99(3):99-106.
1992: Löscher W; Fredow G
Effects of pharmacological manipulation of dopaminergic and cholinergic neurotransmission in genetically dystonic hamsters.
European journal of pharmacology 1992;213(1):31-9.
1992: Hönack D; Rundfeldt C; Löscher W
Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(2):187-96.
1992: Löscher W
[Homeopathy: an effective and risk-free alternative to conventional pharmacotherapy? Part 1: Hahnemann and his teaching]
DTW. Deutsche tierärztliche Wochenschrift 1992;99(2):51-4.
1991: Kietzmann M; Löscher W
[Significance of pharmacokinetic parameters for effective drug therapy in house and domestic animals]
Berliner und Münchener tierärztliche Wochenschrift 1991;104(11):365-9.
1991: Richter A; Fredow G; Löscher W
Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia.
Neuroscience letters 1991;133(1):57-60.
1991: Löscher W; Hönack D; Nolting B; Fassbender C P
Trans-2-en-valproate: reevaluation of its anticonvulsant efficacy in standardized seizure models in mice, rats and dogs.
Epilepsy research 1991;9(3):195-210.
1991: Löscher W; Rundfeldt C; Hönack D
Tolerance to anticonvulsant effects of the partial benzodiazepine receptor agonist abecarnil in kindled rats involves learning.
European journal of pharmacology 1991;202(3):303-10.
1991: Löscher W; Rundfeldt C
Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats.
The Journal of pharmacology and experimental therapeutics 1991;258(2):483-9.
1991: Löscher W; Hönack D; Taylor C P
Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.
Neuroscience letters 1991;128(2):150-4.
1991: Löscher W; von Hodenberg A; Nolting B; Fassbender C P; Taylor C
Ralitoline: a reevaluation of anticonvulsant profile and determination of "active" plasma concentrations in comparison with prototype antiepileptic drugs in mice.
Epilepsia 1991;32(4):560-8.
1991: Löscher W; Annies R; Hönack D
The N-methyl-D-aspartate receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions of rats.
Neuroscience letters 1991;128(2):191-4.
1991: Wahnschaffe U; Löscher W
Anticonvulsant effects of ipsilateral but not contralateral microinjections of the dopamine D2 agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats.
Brain research 1991;553(2):181-7.
1991: Löscher W; Hönack D
The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1146-53.
1991: Löscher W; Nolting B
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices.
Epilepsy research 1991;9(1):1-10.
1991: Löscher W; Hönack D; Fassbender C P; Nolting B
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models.
Epilepsy research 1991;8(3):171-89.
1991: Löscher W; Fassbender C P; Nolting B
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models.
Epilepsy research 1991;8(2):79-94.
1991: Löscher W; Hönack D; Fassbender C P
Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats.
Neuroscience letters 1991;124(1):115-8.
1991: Löscher W; Hönack D
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
The Journal of pharmacology and experimental therapeutics 1991;256(2):432-40.
1991: Hönack D; Wahnschaffe U; Löscher W
Kindling from stimulation of a highly sensitive locus in the posterior part of the piriform cortex. Comparison with amygdala kindling and effects of antiepileptic drugs.
Brain research 1991;538(2):196-202.
1991: Fisher J E; Nau H; Löscher W
Alterations in the renal excretion of valproate and its metabolites after chronic treatment.
Epilepsia 1991;32(1):146-50.
1991: Fredow G; Löscher W
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
European journal of pharmacology 1991;192(2):207-19.
1991: Löscher W; Fredow G; Ganter M
Comparison of pharmacodynamic effects of the non-competitive NMDA receptor antagonists MK-801 and ketamine in pigs.
European journal of pharmacology 1991;192(3):377-82.
1990: Löscher W; Hönack D
The effect of interstimulation interval on the assessment of anticonvulsant drug potency in fully kindled rats.
Epilepsy research 1990;7(3):182-96.
1990: Löscher W; Nolting B; Fassbender C P
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.
Epilepsy research 1990;7(3):173-81.
1990: Löscher W; Hönack D; Scherkl R; Hashem A; Frey H H
Pharmacokinetics, anticonvulsant efficacy and adverse effects of the beta-carboline abecarnil, a novel ligand for benzodiazepine receptors, after acute and chronic administration in dogs.
The Journal of pharmacology and experimental therapeutics 1990;255(2):541-8.
1990: Rundfeldt C; Hönack D; Löscher W
Phenytoin potently increases the threshold for focal seizures in amygdala-kindled rats.
Neuropharmacology 1990;29(9):845-51.
1990: Löscher W; Fassbender C P; Weissing M; Kietzmann M
Drug plasma levels following administration of trimethoprim and sulphonamide combinations to broilers.
Journal of veterinary pharmacology and therapeutics 1990;13(3):309-19.
1990: Löscher W; Witte U; Fredow G; Traber J; Glaser T
The behavioural responses to 8-OH-DPAT, ipsapirone and the novel 5-HT1A receptor agonist Bay Vq 7813 in the pig.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(3):271-7.
1990: Wahnschaffe U; Löscher W
Effect of selective bilateral destruction of the substantia nigra on antiepileptic drug actions in kindled rats.
European journal of pharmacology 1990;186(2-3):157-67.
1990: Kietzmann M; Löscher W
[Peculiarities of pharmacokinetics in young animals]
Berliner und Münchener tierärztliche Wochenschrift 1990;103(8):277-82.
1990: Löscher W; Witte U; Fredow G; Ganter M; Bickhardt K
Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(6):483-93.
1990: Wahnschaffe U; Löscher W
Selective bilateral destruction of substantia nigra has no effect on kindled seizures induced from stimulation of amygdala or piriform cortex in rats.
Neuroscience letters 1990;113(2):205-10.
1990: Löscher W; Hönack D
High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(5):476-81.
1990: Löscher W; Rundfeldt C
Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration.
European journal of pharmacology 1990;180(2-3):255-71.
1990: Löscher W; Ganter M; Fassbender C P
Correlation between drug and metabolite concentrations in plasma and anesthetic action of ketamine in swine.
American journal of veterinary research 1990;51(3):391-8.
1990: Wahnschaffe U; Löscher W
Lesions of the deep prepiriform cortex ('area tempestas') in rats do not affect the convulsant action of systemically administered bicuculline.
Neuroscience letters 1990;108(1-2):161-6.
1990: Wahnschaffe U; Fredow G; Heintz P; Löscher W
Neuropathological studies in a mutant hamster model of paroxysmal dystonia.
Movement disorders : official journal of the Movement Disorder Society 1990;5(4):286-93.
1989: Löscher W; Hönack D; Gramer M
Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid.
Journal of neurochemistry 1989;53(6):1737-50.
1989: Löscher W
Valproate enhances GABA turnover in the substantia nigra.
Brain research 1989;501(1):198-203.
1989: Löscher W; Fisher J E; Nau H; Hönack D
Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment.
The Journal of pharmacology and experimental therapeutics 1989;250(3):1067-78.
1989: Löscher W; Hönack D; Fassbender C P
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
British journal of pharmacology 1989;97(3):843-52.
1989: Hönack D; Löscher W
Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: experiments with carbamazepine.
Neuropharmacology 1989;28(6):599-610.
1989: Löscher W; Jäckel R; Müller F
Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model.
European journal of pharmacology 1989;163(1):1-14.
1989: Löscher W; Hönack D
Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.
European journal of pharmacology 1989;162(2):309-22.
1989: Löscher W; Fisher J E; Schmidt D; Fredow G; Hönack D; Iturrian W B
The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia?
Movement disorders : official journal of the Movement Disorder Society 1989;4(3):219-32.
1988: Löscher W; Nolting B; Hönack D
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
European journal of pharmacology 1988;152(1-2):9-17.
1988: Löscher W; Stephens D N
Chronic treatment with diazepam or the inverse benzodiazepine receptor agonist FG 7142 causes differential changes in the effects of GABA receptor stimulation.
Epilepsy research 1988;2(4):253-9.
1988: Löscher W; Fisher J E; Nau H; Hönack D
Marked increase in anticonvulsant activity but decrease in wet-dog shake behaviour during short-term treatment of amygdala-kindled rats with valproic acid.
European journal of pharmacology 1988;150(3):221-32.
1988: Löscher W; Siemes H
Increased concentration of prostaglandin E-2 in cerebrospinal fluid of children with febrile convulsions.
Epilepsia 1988;29(3):307-10.
1988: Löscher W; Nau H; Siemes H
Penetration of valproate and its active metabolites into cerebrospinal fluid of children with epilepsy.
Epilepsia 1988;29(3):311-6.
1988: Löscher W; Schmidt D
Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations.
Epilepsy research 1988;2(3):145-81.
1988: Löscher W; Lüttgenau H; Schlegel W; Krüger S
Pharmacokinetics of non-steroidal anti-inflammatory drugs in male rabbits after acute and chronic administration and effect of chronic treatment on seminal prostaglandins, sperm quality and fertility.
Journal of reproduction and fertility 1988;82(1):353-64.
1987: Löscher W; Hönack D; Hashem A
Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats.
European journal of pharmacology 1987;143(3):403-14.
1987: Löscher W; Frey H H
One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: anticonvulsant efficacy and alterations in regional brain GABA levels.
European journal of pharmacology 1987;143(3):335-42.
1987: Löscher W; Schwark W S
Further evidence for abnormal GABAergic circuits in amygdala-kindled rats.
Brain research 1987;420(2):385-90.
1987: Czuczwar S J; Jäckel R; Löscher W
Effects of aminophylline and enprofylline on the protective activity of phenobarbital against amygdala-kindled seizures in rats.
Epilepsy research 1987;1(4):234-8.
1987: Löscher W; Czuczwar S J
Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy.
Epilepsy research 1987;1(3):165-72.

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