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Joshua Sommers

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Avvaru N Suhasini; Sharon B Cantor; Yan Coulombe; Jean-Yves Masson; Parameswary A Muniandy; Michael M Seidman; Joshua Sommers; Robert M Brosh
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response.
Yuliang Wu; Caroline Kisker; Hiroyuki Kitao; Jochen Kuper; Jason A Loiland; Joshua Sommers; Robert M Brosh
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Avvaru N Suhasini; Yuliang Wu; Ting Xu; Stephen Yu; Daniel L Kaplan; Zvi Kelman; Joshua Sommers; Robert M Brosh
DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

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All Publications

2013: Avvaru N Suhasini; Sharon B Cantor; Yan Coulombe; Jean-Yves Masson; Parameswary A Muniandy; Michael M Seidman; Joshua Sommers; Robert M Brosh
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response.
Molecular and cellular biology 2013;33(11):2212-27.
2012: Yuliang Wu; Caroline Kisker; Hiroyuki Kitao; Jochen Kuper; Jason A Loiland; Joshua Sommers; Robert M Brosh
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
The Journal of biological chemistry 2012;287(26):21699-716.
2012: Avvaru N Suhasini; Yuliang Wu; Ting Xu; Stephen Yu; Daniel L Kaplan; Zvi Kelman; Joshua Sommers; Robert M Brosh
DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.
The Journal of biological chemistry 2012;287(23):19188-98.
2011: Avvaru N Suhasini; Nina A Rawtani; Yuliang Wu; Joshua Sommers; Sudha Sharma; Georgina Mosedale; Phillip S North; Sharon B Cantor; Ian D Hickson; Robert M Brosh
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.
The EMBO journal 2011;30(4):692-705.
2011: Monika Aggarwal; Joshua Sommers; Robert H Shoemaker; Robert M Brosh
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1525-30.
2010: Yuliang Wu; Joshua Sommers; Avvaru N Suhasini; Thomas Leonard; Julianna S Deakyne; Alexander V Mazin; Kazuo Shin-Ya; Hiroyuki Kitao; Robert M Brosh
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
Blood 2010;116(19):3780-91.
2010: Monika Aggarwal; Joshua Sommers; Christa Morris; Robert M Brosh
Delineation of WRN helicase function with EXO1 in the replicational stress response.
DNA repair 2010;9(7):765-76.
2009: Joshua Sommers; Nina Rawtani; RIGU GUPTA; Dmitry V Bugreev; Alexander V Mazin; Sharon B Cantor; Robert M Brosh
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
The Journal of biological chemistry 2009;284(12):7505-17.
2008: Sudha Sharma; Joshua Sommers; Robert M Brosh
Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases.
Protein and peptide letters 2008;15(1):89-102.
2007: RIGU GUPTA; Sudha Sharma; Joshua Sommers; Mark K Kenny; Sharon B Cantor; Robert M Brosh
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Blood 2007;110(7):2390-8.
2006: RIGU GUPTA; Sudha Sharma; Kevin M Doherty; Joshua Sommers; Sharon B Cantor; Robert M Brosh
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.
Nucleic acids research 2006;34(22):6673-83.
2005: Kevin M Doherty; Joshua Sommers; Matthew D Gray; Jae Wan Lee; Cayetano von Kobbe; Nicolas H Thoma; Raichal P Kureekattil; Mark K Kenny; Robert M Brosh
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
The Journal of biological chemistry 2005;280(33):29494-505.
2005: Sudha Sharma; Joshua Sommers; Saba Choudhary; Jinnifer Korin Faulkner; Sheng Cui; Lucia Andreoli; Laura Muzzolini; Alessandro Vindigni; Robert M Brosh
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.
The Journal of biological chemistry 2005;280(30):28072-84.
2005: RIGU GUPTA; Sudha Sharma; Joshua Sommers; Zhe Jin; Sharon B Cantor; Robert M Brosh
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer.
The Journal of biological chemistry 2005;280(27):25450-60.
2005: Joshua Sommers; Sudha Sharma; Kevin M Doherty; parimal karmakar; Qin Yang; Mark K Kenny; Curtis C Harris; Robert M Brosh
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Cancer research 2005;65(4):1223-33.
2005: Sudha Sharma; Joshua Sommers; Ronald K Gary; Erica Friedrich-Heineken; Ulrich Hübscher; Robert M Brosh
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.
Nucleic acids research 2005;33(21):6769-81.
2004: Sudha Sharma; Joshua Sommers; Robert M Brosh
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
Human molecular genetics 2004;13(19):2247-61.
2004: Saba Choudhary; Joshua Sommers; Robert M Brosh
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
The Journal of biological chemistry 2004;279(33):34603-13.
2004: Sudha Sharma; Joshua Sommers; Leonard Wu; Vilhelm A Bohr; Ian D Hickson; Robert M Brosh
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
The Journal of biological chemistry 2004;279(11):9847-56.
2004: Sudha Sharma; Marit Otterlei; Joshua Sommers; Henry C Driscoll; Grigory L Dianov; Hui-I Kao; Robert A Bambara; Robert M Brosh
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.
Molecular biology of the cell 2004;15(2):734-50.
2003: Sudha Sharma; Joshua Sommers; Henry C Driscoll; Laura Uzdilla; Teresa M Wilson; Robert M Brosh
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.
The Journal of biological chemistry 2003;278(26):23487-96.
2002: Robert M Brosh; Henry C Driscoll; Grigory L Dianov; Joshua Sommers
Biochemical characterization of the WRN-FEN-1 functional interaction.
Biochemistry 2002;41(40):12204-16.
2002: Robert M Brosh; Juwaria Waheed; Joshua Sommers
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase.
The Journal of biological chemistry 2002;277(26):23236-45.
2002: parimal karmakar; Jason Piotrowski; Robert M Brosh; Joshua Sommers; Susan P Lees Miller; Wen-Hsing Cheng; Carey M Snowden; Dale A Ramsden; Vilhelm A Bohr
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
The Journal of biological chemistry 2002;277(21):18291-302.
2001: Robert M Brosh; Cayetano von Kobbe; Joshua Sommers; parimal karmakar; Patricia L Opresko; Jason Piotrowski; Irina I Dianova; Grigory L Dianov; Vilhelm A Bohr
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
The EMBO journal 2001;20(20):5791-801.
2001: Robert M Brosh; parimal karmakar; Joshua Sommers; Qin Yang; Xin Wei Wang; Elisa A Spillare; Curtis C Harris; Vilhelm A Bohr
p53 Modulates the exonuclease activity of Werner syndrome protein.
The Journal of biological chemistry 2001;276(37):35093-102.
2000: Vilhelm A Bohr; M Cooper; David K Orren; Amrita Machwe; Jason Piotrowski; Joshua Sommers; parimal karmakar; Robert M Brosh
Werner syndrome protein: biochemical properties and functional interactions.
Experimental gerontology 2000;35(6-7):695-702.