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Philip Wyde

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Mehran Haidari; Philip Wyde; Silvio Litovsky; Deborah Vela; Muzammil Ali; S Ward Casscells; Mohammad Madjid
Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal mice.
Robert B Couch; Robert L Atmar; Thomas R Cate; John M Quarles; Wendy A Keitel; Nancy H Arden; Janet Wells; Diane Niño; Philip Wyde
Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans.
Douglas M Watts; Clarence Peters; P Newman; Nan Wang; N Yoshikawa; C K Tseng; Philip Wyde
Evaluation of cotton rats as a model for severe acute respiratory syndrome.

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2010: Mehran Haidari; Philip Wyde; Silvio Litovsky; Deborah Vela; Muzammil Ali; S Ward Casscells; Mohammad Madjid
Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal mice.
Atherosclerosis 2010;208(1):90-6.
2009: Robert B Couch; Robert L Atmar; Thomas R Cate; John M Quarles; Wendy A Keitel; Nancy H Arden; Janet Wells; Diane Niño; Philip Wyde
Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans.
Vaccine 2009;27(39):5344-8.
2008: Douglas M Watts; Clarence Peters; P Newman; Nan Wang; N Yoshikawa; C K Tseng; Philip Wyde
Evaluation of cotton rats as a model for severe acute respiratory syndrome.
Vector borne and zoonotic diseases (Larchmont, N.Y.) 2008;8(3):339-44.
2008: Kumari G Lokugamage; Naoko Yoshikawa-Iwata; Naoto Ito; Douglas M Watts; Philip Wyde; Nan Wang; Patrick Newman; Chien-Te Kent Tseng; Clarence Peters; Shinji Makino
Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoV.
Vaccine 2008;26(6):797-808.
2006: Frank M Orson; Berma M Kinsey; Charles L Densmore; Tina Nguyen; Yan Wu; Innocent N Mbawuike; Philip Wyde
Protection against influenza infection by cytokine-enhanced aerosol genetic immunization.
The journal of gene medicine 2006;8(4):488-97.
2006: Kuo-Long Yu; Xiangdong Alan Wang; Rita L Civiello; Ashok K Trehan; Bradley C Pearce; Zhiwei Yin; Keith Combrink; H Belgin Gulgeze; Yi Zhang; Kathleen F Kadow; Christopher Cianci; Junius Clarke; Eugene V Genovesi; Ivette Medina; Lucinda Lamb; Philip Wyde; Mark Krystal; Nicholas A Meanwell
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.
Bioorganic & medicinal chemistry letters 2006;16(5):1115-22.
2005: Joshua O Ojwang; Yan-Hong Wang; Philip Wyde; Nikolaus H Fischer; Wolfgang Schuehly; James R Appleman; Soreeta Hinds; Craig D Shimasaki
A novel inhibitor of respiratory syncytial virus isolated from ethnobotanicals.
Antiviral research 2005;68(3):163-72.
2005: Philip Wyde; Sylvie Laquerre; Srikrishna N Chetty; Brian E Gilbert; Theodore J Nitz; Daniel C Pevear
Antiviral efficacy of VP14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol.
Antiviral research 2005;68(1):18-26.
2005: Philip Wyde; Srikrishna N Chetty; Alan M Jewell; Shauna L Schoonover; Pedro Piedra
Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines.
Antiviral research 2005;66(1):57-66.
2004: Philip Wyde; Edina H Moylett; Srikrishna N Chetty; Alan M Jewell; Terry L Bowlin; Pedro Piedra
Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays.
Antiviral research 2004;63(1):51-9.
2003: Philip Wyde; Srikrishna N Chetty; Philip Timmerman; Brian E Gilbert; Koen Andries
Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection.
Antiviral research 2003;60(3):221-31.
2003: Koen Andries; Marc Moeremans; Tom Gevers; Rudy Willebrords; Cois Sommen; Jean Lacrampe; Frans Janssens; Philip Wyde
Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus.
Antiviral research 2003;60(3):209-19.
2003: Philip Wyde; Srikrishna N Chetty; Alan M Jewell; Guy Boivin; Pedro Piedra
Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro.
Antiviral research 2003;60(1):51-9.
2003: Morteza Naghavi; Philip Wyde; Silvio Litovsky; Mohammad Madjid; Adeeba Akhtar; Sameh Naguib; Mir S Siadaty; Susan Sanati; Ward Casscells
Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient mice.
Circulation 2003;107(5):762-8.
2002: Kevin Otten; Heuy-Ching Wang; Philip Wyde; John R Klein
Modulation of gamma delta T cells in mouse buccal epithelium following antigen priming.
Biochemical and biophysical research communications 2002;294(3):626-9.
2002: Hamida B Qavi; Philip Wyde; Mushtaq A Khan
In vitro Inhibition of HHV-6 replication by sophocarpines.
Phytotherapy research : PTR 2002;16(2):154-6.
2002: Clayton C Huntley; William J Weiss; Anna Gazumyan; Aron Buklan; Boris Feld; William Hu; Thomas R Jones; Timothy Murphy; Antonia Nikitenko; Bryan O'Hara; Gregory Prince; Susan Quartuccio; Yuri Raifeld; Philip Wyde; John F O'Connell
RFI-641, a potent respiratory syncytial virus inhibitor.
Antimicrobial agents and chemotherapy 2002;46(3):841-7.
2002: Yongxin Zhang; Ying Wang; Xyanthine Gilmore; Keyi Xu; Philip Wyde; Innocent N Mbawuike
An aged mouse model for RSV infection and diminished CD8(+) CTL responses.
Experimental biology and medicine (Maywood, N.J.) 2002;227(2):133-40.
2000: Philip Wyde; K J Stittelaar; A D Osterhaus; E Guzman; Brian E Gilbert
Use of cotton rats for preclinical evaluation of measles vaccines.
Vaccine 2000;19(1):42-53.
2000: Philip Wyde; DK Moore-Poveda; E De Clercq; J Neyts; A Matsuda; N Minakawa; E Guzman; Brian E Gilbert
Use of cotton rats to evaluate the efficacy of antivirals in treatment of measles virus infections.
Antimicrobial agents and chemotherapy 2000;44(5):1146-52.
2000: Todd Trask; R P Trask; Estuardo Aguilar-Cordova; Harold Shine; Philip Wyde; J Clay Goodman; Winifred J Hamilton; A Rojas-Martinez; SH Chen; SL Woo; Robert Grossman
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):195-203.
1999: Philip Wyde; DK Moore-Poveda; N J Daley; H Oshitani
Replication of clinical measles virus strains in hispid cotton rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;221(1):53-62.
1998: A Rojas-Martinez; Philip Wyde; Charles Montgomery; SH Chen; SL Woo; Estuardo Aguilar-Cordova
Distribution, persistency, toxicity, and lack of replication of an E1A-deficient adenoviral vector after intracardiac delivery in the cotton rat.
Cancer gene therapy 1998;5(6):365-70.
1998: Philip Wyde
Respiratory syncytial virus (RSV) disease and prospects for its control.
Antiviral research 1998;39(2):63-79.
1998: Janet A Englund; R E Champlin; Philip Wyde; H Kantarjian; Robert L Atmar; Jeffrey J Tarrand; H Yousuf; Helen Regnery; A I Klimov; N J Cox; Estella E Whimbey
Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(6):1418-24.
1998: Philip Wyde; DK Moore-Poveda; Bryan O'Hara; Wei-Dong Ding; Boris Mitsner; Brian E Gilbert
CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats.
Antiviral research 1998;38(1):31-42.
1998: Slawomir Lukomski; EH Burns; Philip Wyde; Andreas Podbielski; J Rurangirwa; DK Moore-Poveda; James M Musser
Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs.
Infection and immunity 1998;66(2):771-6.
1997: Robert Faith; Charles Montgomery; W J Durfee; Estuardo Aguilar-Cordova; Philip Wyde
The cotton rat in biomedical research.
Laboratory animal science 1997;47(4):337-45.
1997: Harold Shine; Philip Wyde; Estuardo Aguilar-Cordova; SH Chen; SL Woo; Robert Grossman; J Clay Goodman
Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat).
Gene therapy 1997;4(4):275-9.
1997: Mark Parrington; S Cockle; Philip Wyde; RP Du; E Snell; W Y Yan; Q Wang; L Gisonni; S Sanhueza; M Ewasyshyn; M Klein
Baculovirus expression of the respiratory syncytial virus fusion protein using Trichoplusia ni insect cells.
Virus genes 1997;14(1):63-72.
1996: Philip Wyde; D K Moore; D M Pimentel; Brian E Gilbert; R Nimrod; A Panet
Recombinant superoxide dismutase (SOD) administered by aerosol inhibits respiratory syncytial virus infection in cotton rats.
Antiviral research 1996;31(3):173-84.
1995: G Taylor; T Porter; S Dillon; J Trill; S Ganguly; T Hart; C Davis; Philip Wyde; P Tempest; W Harris
Anti-respiratory syncytial virus monoclonal antibodies show promise in the treatment and prophylaxis of viral disease.
Biochemical Society transactions 1995;23(4):1063-7.
1995: Philip Wyde; D K Moore; T Hepburn; C L Silverman; T G Porter; M Gross; G Taylor; S G Demuth; S B Dillon
Evaluation of the protective efficacy of reshaped human monoclonal antibody RSHZ19 against respiratory syncytial virus in cotton rats.
Pediatric research 1995;38(4):543-50.
1995: A R Nagendra; C Wayne Smith; Philip Wyde
Evidence that measles virus hemagglutinin initiates modulation of leukocyte function-associated antigen 1 expression.
Journal of virology 1995;69(7):4357-63.
1995: J Simeckova-Rosenberg; Z Yun; Philip Wyde; M Zouhair Atassi
Protection of mice against lethal viral infection by synthetic peptides corresponding to B- and T-cell recognition sites of influenza A hemagglutinin.
Vaccine 1995;13(10):927-32.
1995: Philip Wyde; D K Moore; D M Pimentel; H A Blough
Evaluation of the antiviral activity of N-(phosphonoacetyl)-L-aspartate against paramyxoviruses in tissue culture and against respiratory syncytial virus in cotton rats.
Antiviral research 1995;27(1-2):59-69.
1994: R P Du; G E Jackson; Philip Wyde; W Y Yan; Q Wang; L Gisonni; S E Sanhueza; MH Klein; M Ewasyshyn
A prototype recombinant vaccine against respiratory syncytial virus and parainfluenza virus type 3.
Bio/technology (Nature Publishing Company) 1994;12(8):813-8.
1994: Philip Wyde; N R Attibele; W L Kemp
Infection of leucocytes by measles vaccine viruses Edmonston-Zagreb and Enders-Moraten has different consequences: potential mechanism for increased vaccine efficacy or aberrant activity in field trials.
Vaccine 1994;12(8):715-22.
1994: Brian E Gilbert; Philip Wyde; G Lopez-Berestein; S Z Wilson
Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice.
Antimicrobial agents and chemotherapy 1994;38(2):356-9.
1993: Pedro Piedra; Philip Wyde; W L Castleman; M W Ambrose; A M Jewell; D J Speelman; S W Hildreth
Enhanced pulmonary pathology associated with the use of formalin-inactivated respiratory syncytial virus vaccine in cotton rats is not a unique viral phenomenon.
Vaccine 1993;11(14):1415-23.
1993: Brian E Gilbert; S Z Wilson; N M Garcon; Philip Wyde; Vernon Knight
Characterization and administration of cyclosporine liposomes as a small-particle aerosol.
Transplantation 1993;56(4):974-7.
1993: Innocent N Mbawuike; Philip Wyde
Induction of CD8+ cytotoxic T cells by immunization with killed influenza virus and effect of cholera toxin B subunit.
Vaccine 1993;11(12):1205-13.
1993: Brian E Gilbert; Philip Wyde; S Z Wilson; L R Meyerson
SP-303 small-particle aerosol treatment of influenza A virus infection in mice and respiratory syncytial virus infection in cotton rats.
Antiviral research 1993;21(1):37-45.
1993: Philip Wyde; M W Ambrose; L R Meyerson; Brian E Gilbert
The antiviral activity of SP-303, a natural polyphenolic polymer, against respiratory syncytial and parainfluenza type 3 viruses in cotton rats.
Antiviral research 1993;20(2):145-54.
1993: N Attibele; Philip Wyde; JoAnn Trial; S C Smole; C Wayne Smith; Roger Rossen
Measles virus-induced changes in leukocyte function antigen 1 expression and leukocyte aggregation: possible role in measles virus pathogenesis.
Journal of virology 1993;67(2):1075-9.
1993: M W Ambrose; Philip Wyde
Parainfluenza virus type 3 (PIV3)-specific and non-virus-specific delayed type hypersensitivity responses in cotton rats given different PIV3 antigen preparations.
Vaccine 1993;11(3):336-42.
1992: Philip Wyde; M W Ambrose; T G Voss; H L Meyer; Brian E Gilbert
Measles virus replication in lungs of hispid cotton rats after intranasal inoculation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;201(1):80-7.
1992: Brian E Gilbert; Philip Wyde; S Z Wilson
Aerosolized liposomal amphotericin B for treatment of pulmonary and systemic Cryptococcus neoformans infections in mice.
Antimicrobial agents and chemotherapy 1992;36(7):1466-71.
1992: Brian E Gilbert; Philip Wyde; M W Ambrose; S Z Wilson; Vernon Knight
Further studies with short duration ribavirin aerosol for the treatment of influenza virus infection in mice and respiratory syncytial virus infection in cotton rats.
Antiviral research 1992;17(1):33-42.
1991: Brian E Gilbert; Philip Wyde; S Z Wilson; R K Robins
Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus.
Antimicrobial agents and chemotherapy 1991;35(7):1448-53.
1991: M W Ambrose; Philip Wyde; M Ewasyshyn; A M Bonneau; B Caplan; H L Meyer; M Klein
Evaluation of the immunogenicity and protective efficacy of a candidate parainfluenza virus type 3 subunit vaccine in cotton rats.
Vaccine 1991;9(7):505-11.
1991: Vernon Knight; Brian E Gilbert; Philip Wyde; Janet A Englund
High dose-short duration ribavirin aerosol treatment--a review.
Bulletin of the International Union against Tuberculosis and Lung Disease 1991;66(2-3):97-101.
1991: J R Rodgers; Philip Wyde; Robert R Rich
Mutational analysis of regulation of MHC and anti-viral genes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1979-86.
1990: Philip Wyde; M W Ambrose; H L Meyer; Brian E Gilbert
Toxicity and antiviral activity of LY253963 against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.
Antiviral research 1990;14(4-5):237-47.
1990: Philip Wyde; M W Ambrose; H L Meyer; C L Zolinski; Brian E Gilbert
Evaluation of the toxicity and antiviral activity of carbocyclic 3-deazaadenosine against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.
Antiviral research 1990;14(4-5):215-25.
1990: Innocent N Mbawuike; Philip Wyde; P M Anderson
Enhancement of the protective efficacy of inactivated influenza A virus vaccine in aged mice by IL-2 liposomes.
Vaccine 1990;8(4):347-52.
1990: Philip Wyde; H R Six; M W Ambrose; B J Throop
Muramyl peptides and polyinosinic-polycytodylic acid given to mice prior to influenza virus challenge reduces pulmonary disease and mortality.
Journal of biological response modifiers 1990;9(1):98-102.
1989: Philip Wyde; H R Six; M W Ambrose; B J Throop
Influenza virus infection and bacterial clearance in young adult and aged mice.
Journal of gerontology 1989;44(5):B118-24.
1989: Philip Wyde; Brian E Gilbert; M W Ambrose
Comparison of the anti-respiratory syncytial virus activity and toxicity of papaverine hydrochloride and pyrazofurin in vitro and in vivo.
Antiviral research 1989;11(1):15-26.
1989: M Zouhair Atassi; José V Torres; Philip Wyde
Cytotoxic and helper T-lymphocyte responses to antibody recognition regions on influenza virus hemagglutinin.
Advances in experimental medicine and biology 1989;251():49-63.
1988: José V Torres; Philip Wyde; M Zouhair Atassi
Cytotoxic T lymphocyte recognition sites on influenza virus hemagglutinin.
Immunology letters 1988;19(1):49-53.
1988: Brian E Gilbert; H R Six; S Z Wilson; Philip Wyde; Vernon Knight
Small particle aerosols of enviroxime-containing liposomes.
Antiviral research 1988;9(6):355-65.
1988: F I Farag-Mahmod; Philip Wyde; J P Rosborough; H R Six
Immunogenicity and efficacy of orally administered inactivated influenza virus vaccine in mice.
Vaccine 1988;6(3):262-8.
1988: Philip Wyde; H R Six; S Z Wilson; Brian E Gilbert; Vernon Knight
Activity against rhinoviruses, toxicity, and delivery in aerosol of enviroxime in liposomes.
Antimicrobial agents and chemotherapy 1988;32(6):890-5.
1988: Brian E Gilbert; Philip Wyde
Pharmacokinetics of ribavirin aerosol in mice.
Antimicrobial agents and chemotherapy 1988;32(1):117-21.
1988: M C Goldschmidt; W J Masin; L R Brown; Philip Wyde
The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1988;58(3):326-34.
1987: Philip Wyde; S Z Wilson; R Petrella; Brian E Gilbert
Efficacy of high dose-short duration ribavirin aerosol in the treatment of respiratory syncytial virus infected cotton rats and influenza B virus infected mice.
Antiviral research 1987;7(4):211-20.
1987: W C Gruber; S Z Wilson; B J Throop; Philip Wyde
Immunoglobulin administration and ribavirin therapy: efficacy in respiratory syncytial virus infection of the cotton rat.
Pediatric research 1987;21(3):270-4.
1986: Philip Wyde; S Z Wilson; Brian E Gilbert; R H Smith
Protection of mice from lethal influenza virus infection with high dose-short duration ribavirin aerosol.
Antimicrobial agents and chemotherapy 1986;30(6):942-4.
1986: C S Sun; S Z Wilson; Philip Wyde
Limited efficacy of aerosolized recombinant alpha interferon against virulent influenza A/HK infection in mice.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1986;181(2):298-304.
1985: Philip Wyde; C S Sun; S Z Wilson; Vernon Knight
Duration of effect of interferon aerosol prophylaxis of vesicular stomatitis virus infection in mice.
Antimicrobial agents and chemotherapy 1985;27(1):60-4.
1984: Philip Wyde; S Z Wilson; C S Sun; Vernon Knight
Interferon aerosol suppression of vesicular stomatitis virus replication in the lungs of infected mice.
Antimicrobial agents and chemotherapy 1984;26(4):450-4.
1984: Philip Wyde; S Z Wilson; M J Kramer; C S Sun; Vernon Knight
Pulmonary deposition and clearance of aerosolized interferon.
Antimicrobial agents and chemotherapy 1984;25(6):729-34.
1984: C S Sun; Philip Wyde; S Z Wilson; Vernon Knight
Efficacy of aerosolized recombinant interferons against vesicular stomatitis virus-induced lung infection in cotton rats.
Journal of interferon research 1984;4(4):449-59.
1983: C S Sun; Philip Wyde; Vernon Knight
Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection.
The American review of respiratory disease 1983;128(4):668-72.
1983: Philip Wyde; C S Sun; Vernon Knight
Replication of respiratory syncytial virus in lungs of immunodeficient mice.
Journal of the Reticuloendothelial Society 1983;34(2):125-9.
1983: Philip Wyde; Brian E Gilbert; B M Levy
Evidence that T-lymphocytes are part of the blood-brain barrier to virus dissemination.
Journal of neuroimmunology 1983;5(1):47-58.
1983: C S Sun; Philip Wyde; S Z Wilson; Vernon Knight
Cell-mediated cytotoxic responses in lungs of cotton rats infected with respiratory syncytial virus.
The American review of respiratory disease 1983;127(4):460-4.
1982: Philip Wyde; M R Wilson; T R Cate
Interferon production by leukocytes infiltrating the lungs of mice during primary influenza virus infection.
Infection and immunity 1982;38(3):1249-55.
1982: K A Kimmel; Philip Wyde; W P Glezen
Evidence of a T-cell-mediated cytotoxic response to parainfluenza virus type 3 pneumonia in hamsters.
Journal of the Reticuloendothelial Society 1982;31(1):71-83.
1980: S Z Wilson; Vernon Knight; Philip Wyde; S Drake; Robert B Couch
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.
Antimicrobial agents and chemotherapy 1980;17(4):642-8.
1979: Philip Wyde; T R Cate
Appearance of rosette-forming macrophages in the lungs of influenza virus-infected mice.
Infection and immunity 1979;25(3):986-91.
1978: Philip Wyde; T R Cate
Cellular changes in lungs of mice infected with influenza virus: characterization of the cytotoxic responses.
Infection and immunity 1978;22(2):423-9.
1978: Philip Wyde; D L Peavy; T R Cate
Morphological and cytochemical characterization of cells infiltrating mouse lungs after influenza infection.
Infection and immunity 1978;21(1):140-6.
1977: Philip Wyde; R B Couch; B F Mackler; T R Cate; B M Levy
Effects of low- and high-passage influenza virus infection in normal and nude mice.
Infection and immunity 1977;15(1):221-9.
1975: P O'Neill; B F Mackler; Philip Wyde
Complement (C3) receptor-bearing lymphocyte-mediated cytotoxicity and lymphotoxin responses.
Cellular immunology 1975;20(1):33-41.
1975: J T Boyer; Philip Wyde; M Bier
Hypochlorite-induced alterations to canine serum complement.
Clinical and experimental immunology 1975;21(2):345-50.