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Daniel Ricklin

Research Profile

Chemicals & Drugs

Living Beings

Staphylococcus aureus

Phenomena

Protein Binding

Concepts & Ideas

Procedures

Surface Plasmon Resonance

Physiology

Co-author Network

Publications

TOP 3
Daniel Ricklin; John D Lambris
Complement in immune and inflammatory disorders: therapeutic interventions.
Daniel Ricklin; John D Lambris
Complement in immune and inflammatory disorders: pathophysiological mechanisms.
Hongchang Qu; Edimara S Reis; Ranillo R G Resuello; Daniel Ricklin; Apostolia Tzekou; Hongjun Bai; Paul N Barlow; Hui Chen; Robert A DeAngelis; Florea Lupu; Mateusz Maciejewski; John D Lambris
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.

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All Publications

2013: Daniel Ricklin; John D Lambris
Complement in immune and inflammatory disorders: therapeutic interventions.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):3839-47.
2013: Daniel Ricklin; John D Lambris
Complement in immune and inflammatory disorders: pathophysiological mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):3831-8.
2013: Hongchang Qu; Edimara S Reis; Ranillo R G Resuello; Daniel Ricklin; Apostolia Tzekou; Hongjun Bai; Paul N Barlow; Hui Chen; Robert A DeAngelis; Florea Lupu; Mateusz Maciejewski; John D Lambris
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.
Immunobiology 2013;218(4):496-505.
2013: Brandon L Garcia; John H Laity; John D Lambris; Zhuoer Lin; Kasra X Ramyar; Daniel Ricklin; Brady J Summers; Apostolia Tzekou; Brian V Geisbrecht
A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.
The Journal of biological chemistry 2013;288(4):2870-81.
2013: Kun Yang; Robert A DeAngelis; Janet E Reed; Daniel Ricklin; John D Lambris
Complement in action: an analysis of patent trends from 1976 through 2011.
Advances in experimental medicine and biology 2013;735():301-13.
2013: Daniel Ricklin; John D Lambris
Progress and trends in complement therapeutics.
Advances in experimental medicine and biology 2013;735():1-22.
2013: Kun Yang; Robert A DeAngelis; Janet E Reed; Daniel Ricklin; John D Lambris
Complement in action: an analysis of patent trends from 1976 through 2011.
Advances in experimental medicine and biology 2013;734a():301-13.
2013: Daniel Ricklin; John D Lambris
Progress and trends in complement therapeutics.
Advances in experimental medicine and biology 2013;734a():1-22.
2012: Toshiharu Abe; Evlambia Hajishengallis; Kavita B Hosur; John D Lambris; Edimara S Reis; Daniel Ricklin; George Hajishengallis
Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(11):5442-8.
2012: Edimara S Reis; Daniel Ricklin; Georgia Sfyroera; Hui Chen; Jörg Köhl; Peter N Monk; John D Lambris
C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4797-805.
2012: Robert A DeAngelis; Edimara S Reis; Daniel Ricklin; John D Lambris
Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis.
Immunobiology 2012;217(11):1097-105.
2012: Daniel Ricklin
Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.
Immunobiology 2012;217(11):1057-66.
2012: John D Lambris; George Hajishengallis; Daniel Ricklin
The XXIV International Complement Workshop (ICW) on October 10-15, 2012. Preface.
Immunobiology 2012;217(11):1025.
2012: Daniel Ricklin; Edimara S Reis; John D Lambris
A sweet spot to control complement-induced inflammation.
Nature medicine 2012;18(9):1340-1.
2012: Brandon L Garcia; John D Lambris; Kasra X Ramyar; Daniel Ricklin; Brian V Geisbrecht
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
Advances in experimental medicine and biology 2012;946():113-33.
2011: You-Qiang Wu; Hongchang Qu; Georgia Sfyroera; Apostolia Tzekou; Brian Kay; Bo Nilsson; Kristina Nilsson-Ekdahl; Daniel Ricklin; John D Lambris
Protection of nonself surfaces from complement attack by factor H-binding peptides: implications for therapeutic medicine.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4269-77.
2011: Hongchang Qu; Paola Magotti; Daniel Ricklin; Emilia L Wu; Ioannis Kourtzelis; You-Qiang Wu; Yiannis N Kaznessis; John D Lambris
Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency.
Molecular immunology 2011;48(4):481-9.
2010: Federico Forneris; Daniel Ricklin; Jin Wu; Apostolia Tzekou; Rachel S Wallace; John D Lambris; Piet Gros
Structures of C3b in complex with factors B and D give insight into complement convertase formation.
Science (New York, N.Y.) 2010;330(6012):1816-20.
2010: H Chen; Daniel Ricklin; Michal Hammel; Brandon L Garcia; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; Apostolia Tzekou; Sheng Li; Brian V Geisbrecht; Virgil L Woods; John D Lambris
Allosteric inhibition of complement function by a staphylococcal immune evasion protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17621-6.
2010: Brandon L Garcia; Kasra X Ramyar; Apostolia Tzekou; Daniel Ricklin; William J McWhorter; John D Lambris; Brian V Geisbrecht
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.
Journal of molecular biology 2010;402(1):17-29.
2010: Daniel Ricklin; George Hajishengallis; Kun Yang; John D Lambris
Complement: a key system for immune surveillance and homeostasis.
Nature immunology 2010;11(9):785-97.
2009: Hongchang Qu; Daniel Ricklin; John D Lambris
Recent developments in low molecular weight complement inhibitors.
Molecular immunology 2009;47(2-3):185-95.
2009: Paola Magotti; Daniel Ricklin; Hongchang Qu; You-Qiang Wu; Yiannis N Kaznessis; John D Lambris
Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin.
Journal of molecular recognition : JMR 2009;22(6):495-505.
2009: Daniel Ricklin; Apostolia Tzekou; Brandon L Garcia; Michal Hammel; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; V Michael Holers; Andrew Herbert; Paul N Barlow; Brian V Geisbrecht; John D Lambris
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2565-74.
2008: Daniel Ricklin; Salome K Ricklin-Lichtsteiner; Maciej Markiewski; Brian V Geisbrecht; John D Lambris
Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7463-7.
2008: Nurit Haspel; Daniel Ricklin; Brian V Geisbrecht; Lydia E Kavraki; John D Lambris
Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.
Protein science : a publication of the Protein Society 2008;17(11):1894-906.
2008: Michael C Schuster; Daniel Ricklin; Krisztián Papp; Kathleen S Molnar; Stephen J Coales; Yoshitomo Hamuro; Georgia Sfyroera; Hui Chen; Michael S Winters; John D Lambris
Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry.
Molecular immunology 2008;45(11):3142-51.
2008: John D Lambris; Daniel Ricklin; Brian V Geisbrecht
Complement evasion by human pathogens.
Nature reviews. Microbiology 2008;6(2):132-42.
2008: Daniel Ricklin; John D Lambris
Compstatin: a complement inhibitor on its way to clinical application.
Advances in experimental medicine and biology 2008;632():273-92.
2007: Daniel Ricklin; John D Lambris
Complement-targeted therapeutics.
Nature biotechnology 2007;25(11):1265-75.
2007: Michal Hammel; Georgia Sfyroera; Serapion Pyrpassopoulos; Daniel Ricklin; Kasra X Ramyar; Mihai Pop; Zhongmin Jin; John D Lambris; Brian V Geisbrecht
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus.
The Journal of biological chemistry 2007;282(41):30051-61.
2007: Michal Hammel; Georgia Sfyroera; Daniel Ricklin; Paola Magotti; John D Lambris; Brian V Geisbrecht
A structural basis for complement inhibition by Staphylococcus aureus.
Nature immunology 2007;8(4):430-7.
2007: Daniel Ricklin; John D Lambris
Exploring the complement interaction network using surface plasmon resonance.
Advances in experimental medicine and biology 2007;598():260-78.
2005: Lars Herfurth; Beat Ernst; Beatrice Wagner; Daniel Ricklin; Daniel S Strasser; John L Magnani; Andrew J Benie; Thomas Peters
Comparative epitope mapping with saturation transfer difference NMR of sialyl Lewis(a) compounds and derivatives bound to a monoclonal antibody.
Journal of medicinal chemistry 2005;48(22):6879-86.