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Olivier Boss

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Obesity

Living Beings

Physiology

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Publications

TOP 3
Jesse J Smith; Renée Deehan Kenney; David J Gagne; Brian P Frushour; William Ladd; Heidi L Galonek; Kristine Israelian; Jeffrey Song; Giedre Razvadauskaite; Amy V Lynch; David P Carney; Robin J Johnson; Siva Lavu; Andre Iffland; Peter J Elliott; Philip D Lambert; keith elliston; Michael R Jirousek; Jill C Milne; Olivier Boss
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
Siva Lavu; Olivier Boss; Peter J Elliott; Philip D Lambert
Sirtuins--novel therapeutic targets to treat age-associated diseases.
Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

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All Publications

2009: Jesse J Smith; Renée Deehan Kenney; David J Gagne; Brian P Frushour; William Ladd; Heidi L Galonek; Kristine Israelian; Jeffrey Song; Giedre Razvadauskaite; Amy V Lynch; David P Carney; Robin J Johnson; Siva Lavu; Andre Iffland; Peter J Elliott; Philip D Lambert; keith elliston; Michael R Jirousek; Jill C Milne; Olivier Boss
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
BMC systems biology 2009;3():31.
2008: Siva Lavu; Olivier Boss; Peter J Elliott; Philip D Lambert
Sirtuins--novel therapeutic targets to treat age-associated diseases.
Nature reviews. Drug discovery 2008;7(10):841-53.
2007: Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature 2007;450(7170):712-6.
2007: Zhidan Wu; Olivier Boss
Targeting PGC-1 alpha to control energy homeostasis.
Expert opinion on therapeutic targets 2007;11(10):1329-38.
2007: Davide Mainieri; Jean-Pierre Montani; Josiane Seydoux; Jean-Paul Giacobino; Olivier Boss; Abdul G Dulloo
beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis.
International journal of obesity (2005) 2007;31(2):378-81.
2007: Karl G Hofbauer; Janet R Nicholson; Olivier Boss
The obesity epidemic: current and future pharmacological treatments.
Annual review of pharmacology and toxicology 2007;47():565-92.
2006: Joseph A Baur; Kevin J Pearson; Nathan L Price; Hamish A Jamieson; Carles Lerin; Avash Kalra; Vinayakumar V Prabhu; Joanne S Allard; Guillermo Lopez-LLuch; Kaitlyn Lewis; Paul J Pistell; Suresh Poosala; Kevin G Becker; Olivier Boss; Dana Gwinn; Mingyi Wang; Sharan Ramaswamy; Kenneth W Fishbein; RICHARD SPENCER; Edward G Lakatta; DAVID LE COUTEUR; Reuben J. Shaw; Plácido Navas; Pere Puigserver; Donald Ingram; Rafael de Cabo; David A Sinclair
Resveratrol improves health and survival of mice on a high-calorie diet.
Nature 2006;444(7117):337-42.
2006: Davide Mainieri; Serge Summermmatter; Josiane Seydoux; Jean-Pierre Montani; Sandro Rusconi; Aaron P Russell; Olivier Boss; Antony Joseph Buchala; Abdul G Dulloo
A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1751-3.
2006: Lora K Heisler; Erin E Jobst; Gregory M Sutton; Ligang Zhou; Erzsebet Borok; Zoe Thornton-Jones; Hong Yan Liu; Jeffrey M Zigman; Nina Balthasar; Toshiro Kishi; Charlotte E Lee; Carl J Aschkenasi; Chen-Yu zhang; Jia Yu; Olivier Boss; Kathleen G Mountjoy; Peter G Clifton; Bradford B Lowell; Jeffrey M Friedman; Tamas L Horvath; Andrew A Butler; Joel K Elmquist; Michael Alexander cowley
Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Neuron 2006;51(2):239-49.
2006: Olivier Boss; Nils Bergenhem
Adipose targets for obesity drug development.
Expert opinion on therapeutic targets 2006;10(1):119-34.
2005: Nina Balthasar; Louise Torp Dalgaard; Charlotte E Lee; Jia Yu; Hisayuki Funahashi; Todd Williams; Manuel Ferreira; Vinsee Tang; Robert A McGovern; Christopher D Kenny; Lauryn M Christiansen; Elizabeth Edelstein; Brian Choi; Olivier Boss; Carl J Aschkenasi; Chen-Yu zhang; Kathleen G Mountjoy; Toshiro Kishi; Joel K Elmquist; Bradford B Lowell
Divergence of melanocortin pathways in the control of food intake and energy expenditure.
Cell 2005;123(3):493-505.
2004: Ko Kotani; Odile D Peroni; Yasuhiko Minokoshi; Olivier Boss; Barbara B Kahn
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
The Journal of clinical investigation 2004;114(11):1666-75.
2002: Jiandie Lin; Hai Wu; Paul T Tarr; Chen-Yu zhang; Zhidan Wu; Olivier Boss; Laura F Michael; Pere Puigserver; Eiji Isotani; Eric N Olson; Bradford B Lowell; Rhonda Bassel-Duby; Bruce M Spiegelman
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature 2002;418(6899):797-801.
2002: Abdul G Dulloo; Michael J Stock; Giovanni Solinas; Olivier Boss; Jean-Pierre Montani; Josiane Seydoux
Leptin directly stimulates thermogenesis in skeletal muscle.
FEBS letters 2002;515(1-3):109-13.
2001: Chen-Yu zhang; György Baffy; P Perret; S Krauss; Odile D Peroni; D Grujic; T Hagen; Antonio Vidal-Puig; Olivier Boss; Y B Kim; X X Zheng; M B Wheeler; Gerald I Shulman; C B Chan; Bradford B Lowell
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Cell 2001;105(6):745-55.
2001: Janice M Zabolotny; Young-Bum Kim; Odile D Peroni; Jason K Kim; Michael Aleksander Pani; Olivier Boss; Lori D Klaman; S Kamatkar; Gerald I Shulman; Barbara B Kahn; Benjamin G Neel
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5187-92.
2001: Cláudia R Vianna; T Hagen; Chen-Yu zhang; Eric S Bachman; Olivier Boss; Balázs Gereben; Anselmo S Moriscot; Bradford B Lowell; José Eduardo P W Bicudo; Antonio Bianco
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
Physiological genomics 2001;5(3):137-45.
2001: V Luukkaa; Eriika Savontaus; Juha Rouru; Kirsi A Virtanen; Olivier Boss; Ilpo Huhtaniemi; Markku Koulu; Ullamari Pesonen; Risto Huupponen
Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2001;15(2):103-12.
2001: E Dale Abel; Odile D Peroni; J K Kim; Y B Kim; Olivier Boss; E Hadro; T Minnemann; Gerald I Shulman; Barbara B Kahn
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Nature 2001;409(6821):729-33.
2000: Anthony G Comuzzie; Laura A Almasy; Shelley A Cole; Olivier Boss; Jean-Paul Giacobino; Patrick Muzzin; Michael P Stern; Jean W MacCluer; John C Blangero; James E Hixson
Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(8):1065-8.
2000: Lori D Klaman; Olivier Boss; Odile D Peroni; Jason K Kim; J L Martino; Janice M Zabolotny; N Moghal; M Lubkin; Young-Bum Kim; A H Sharpe; Alain Stricker-Krongrad; Gerald I Shulman; Benjamin G Neel; Barbara B Kahn
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Molecular and cellular biology 2000;20(15):5479-89.
2000: Jonathan Pinkney; Olivier Boss; George A Bray; Karen Bulmer; Simon W Coppack; Vidya Mohamed-Ali
Physiological relationships of uncoupling protein-2 gene expression in human adipose tissue in vivo.
The Journal of clinical endocrinology and metabolism 2000;85(6):2312-7.
2000: Antonio Vidal-Puig; D Grujic; Chen-Yu zhang; T Hagen; Olivier Boss; Y Ido; A Szczepanik; J Wade; Vamsi K Mootha; Ronald N Cortright; D M Muoio; Bradford B Lowell
Energy metabolism in uncoupling protein 3 gene knockout mice.
The Journal of biological chemistry 2000;275(21):16258-66.
2000: Olivier Boss; T Hagen; Bradford B Lowell
Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.
Diabetes 2000;49(2):143-56.
2000: A Gorla-Bajszczak; CA Siegrist-Kaiser; Olivier Boss; Albert G Burger; Christoph A Meier
Expression of peroxisome proliferator-activated receptors in lean and obese Zucker rats.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(1):71-8.
1999: Patrick Muzzin; Olivier Boss; Jean-Paul Giacobino
Uncoupling protein 3: its possible biological role and mode of regulation in rodents and humans.
Journal of bioenergetics and biomembranes 1999;31(5):467-73.
1999: Olivier Boss; Eric S Bachman; Antonio Vidal-Puig; Chen-Yu zhang; Odile D Peroni; Bradford B Lowell
Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1.
Biochemical and biophysical research communications 1999;261(3):870-6.
1999: Antonia Lanni; Luca Beneduce; Assunta Lombardi; Maria Moreno; Olivier Boss; Patrick Muzzin; Jean-Paul Giacobino; Fernando Goglia
Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle.
FEBS letters 1999;444(2-3):250-4.
1999: KE Zakrzewska; I Cusin; Alain Stricker-Krongrad; Olivier Boss; D Ricquier; B Jeanrenaud; Françoise Rohner-Jeanrenaud
Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat.
Diabetes 1999;48(2):365-70.
1998: Olivier Boss; Patrick Muzzin; Jean-Paul Giacobino
The uncoupling proteins, a review.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(1):1-9.
1998: I Cusin; KE Zakrzewska; Olivier Boss; Patrick Muzzin; Jean-Paul Giacobino; D Ricquier; B Jeanrenaud; Françoise Rohner-Jeanrenaud
Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.
Diabetes 1998;47(7):1014-9.
1998: Olivier Boss; Elisabetta Bobbioni-Harsch; Françoise Assimacopoulos-Jeannet; Patrick Muzzin; R Munger; Jean-Paul Giacobino; A Golay
Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obesity.
Lancet 1998;351(9120):1933.
1998: Eriika Savontaus; Juha Rouru; Olivier Boss; Risto Huupponen; Markku Koulu
Differential regulation of uncoupling proteins by chronic treatments with beta 3-adrenergic agonist BRL 35135 and metformin in obese fa/fa Zucker rats.
Biochemical and biophysical research communications 1998;246(3):899-904.
1998: Olivier Boss; Sonia Samec; Dominique Desplanches; MH Mayet; Josiane Seydoux; Patrick Muzzin; Jean-Paul Giacobino
Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(3):335-9.
1998: Olivier Boss; Jean-Paul Giacobino; Patrick Muzzin
Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13.
Genomics 1998;47(3):425-6.
1998: Olivier Boss; Sonia Samec; Françoise Kühne; Philippe Bijlenga; Françoise Assimacopoulos-Jeannet; Josiane Seydoux; Jean-Paul Giacobino; Patrick Muzzin
Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature.
The Journal of biological chemistry 1998;273(1):5-8.
1998: E Kutoh; Olivier Boss; F Levasseur; Jean-Paul Giacobino
Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue.
Life sciences 1998;62(5):445-51.
1997: CA Siegrist-Kaiser; V Pauli; Cristiana E Juge-Aubry; Olivier Boss; Agnès Pernin; W W Chin; I Cusin; Françoise Rohner-Jeanrenaud; Albert G Burger; J Zapf; Christoph A Meier
Direct effects of leptin on brown and white adipose tissue.
The Journal of clinical investigation 1997;100(11):2858-64.
1997: JP Revelli; Frédéric Preitner; Sonia Samec; P Muniesa; Françoise Kuehne; Olivier Boss; Jean-Dominique Vassalli; Abdul G Dulloo; Josiane Seydoux; Jean-Paul Giacobino; Joachim Huarte; C Ody
Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition.
The Journal of clinical investigation 1997;100(5):1098-106.
1997: Olivier Boss; Sonia Samec; Abdul G Dulloo; Josiane Seydoux; Patrick Muzzin; Jean-Paul Giacobino
Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold.
FEBS letters 1997;412(1):111-4.
1997: Olivier Boss; Sonia Samec; Ariane Paoloni-Giacobino; Colette Rossier; Abdul G Dulloo; Josiane Seydoux; Patrick Muzzin; Jean-Paul Giacobino
Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.
FEBS letters 1997;408(1):39-42.
1997: C Deng; M Moinat; Logos Curtis; A Nadakal; Frédéric Preitner; Olivier Boss; Françoise Assimacopoulos-Jeannet; Josiane Seydoux; Jean-Paul Giacobino
Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture.
Endocrinology 1997;138(2):548-52.
1996: C Deng; Ariane Paoloni-Giacobino; F Kuehne; Olivier Boss; J P Revelli; M Moinat; Michael A Cawthorne; Patrick Muzzin; Jean-Paul Giacobino
Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.
British journal of pharmacology 1996;118(4):929-34.
1994: Patrick Muzzin; Olivier Boss; N Mathis; J P Revelli; Jean-Paul Giacobino; K Willcocks; G T Badman; B C Cantello; R M Hindley; Michael A Cawthorne
Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606.
Molecular pharmacology 1994;46(2):357-63.