Terrence Burke

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Kessl Jacques J; Eidahl Jocelyn O; Shkriabai Nikolozi; Zhao Zhuojun; McKee Christopher J; Hess Sonja; Burke Terrence R; Kvaratskhelia Mamuka
An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.
Yun Sang-Moon; Moulaei Tinoush; Lim Dan; Bang Jeong K; Park Jung-Eun; Shenoy Shilpa R; Liu Fa; Kang Young H; Liao Chenzhong; Soung Nak-Kyun; Lee Sunhee; Yoon Do-Young; Lim Yoongho; Lee Dong-Hee; Otaka Akira; Appella Ettore; McMahon James B; Nicklaus Marc C; Burke Terrence R; Yaffe Michael B; Wlodawer Alexander; Lee Kyung S
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Zhao Xue Zhi; Maddali Kasthuraiah; Marchand Christophe; Pommier Yves; Burke Terrence R
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.

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All Publications

2009: Kessl Jacques J; Eidahl Jocelyn O; Shkriabai Nikolozi; Zhao Zhuojun; McKee Christopher J; Hess Sonja; Burke Terrence R; Kvaratskhelia Mamuka
An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.
Molecular pharmacology 2009;76(4):824-32.
2009: Yun Sang-Moon; Moulaei Tinoush; Lim Dan; Bang Jeong K; Park Jung-Eun; Shenoy Shilpa R; Liu Fa; Kang Young H; Liao Chenzhong; Soung Nak-Kyun; Lee Sunhee; Yoon Do-Young; Lim Yoongho; Lee Dong-Hee; Otaka Akira; Appella Ettore; McMahon James B; Nicklaus Marc C; Burke Terrence R; Yaffe Michael B; Wlodawer Alexander; Lee Kyung S
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nature structural & molecular biology 2009;16(8):876-82.
2009: Zhao Xue Zhi; Maddali Kasthuraiah; Marchand Christophe; Pommier Yves; Burke Terrence R
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorganic & medicinal chemistry 2009;17(14):5318-24.
2009: Zhao Xue Zhi; Maddali Kasthuraiah; Vu B Christie; Marchand Christophe; Hughes Stephen H; Pommier Yves; Burke Terrence R
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorganic & medicinal chemistry letters 2009;19(10):2714-7.
2009: Cao Xuefei; Plasencia Carmen; Kanzaki Atsuko; Yang Austin; Burke Terrence R; Neamati Nouri
Elucidation of the molecular mechanisms of a salicylhydrazide class of compounds by proteomic analysis.
Current cancer drug targets 2009;9(2):189-201.
2009: Choi Won Jun; Kim Sung-Eun; Stephen Andrew G; Weidlich Iwona; Giubellino Alessio; Liu Fa; Worthy Karen M; Bindu Lakshman; Fivash Matthew J; Nicklaus Marc C; Bottaro Donald P; Fisher Robert J; Burke Terrence R
Identification of Shc Src homology 2 domain-binding peptoid-peptide hybrids.
Journal of medicinal chemistry 2009;52(6):1612-8.
2009: Peach Megan L; Tan Nelly; Choyke Sarah J; Giubellino Alessio; Athauda Gagani; Burke Terrence R; Nicklaus Marc C; Bottaro Donald P
Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening.
Journal of medicinal chemistry 2009;52(4):943-51.
2008: Giubellino Alessio; Shi Zhen-Dan; Jenkins Lisa M Miller; Worthy Karen M; Bindu Lakshman K; Athauda Gagani; Peruzzi Benedetta; Fisher Robert J; Appella Ettore; Burke Terrence R; Bottaro Donald P
Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist.
Journal of medicinal chemistry 2008;51(23):7459-68.
2008: Thomas Joshua D; Hofer Thomas; Rader Christoph; Burke Terrence R
Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates.
Bioorganic & medicinal chemistry letters 2008;18(21):5785-8.
2008: Hofer Thomas; Thomas Joshua D; Burke Terrence R; Rader Christoph
An engineered selenocysteine defines a unique class of antibody derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12451-6.
2008: Giubellino Alessio; Burke Terrence R; Bottaro Donald P
Grb2 signaling in cell motility and cancer.
Expert opinion on therapeutic targets 2008;12(8):1021-33.
2007: Liu Fa; Worthy Karen M; Bindu Lakshman K; Fisher Robert J; Burke Terrence R
Structural examination of ring-closing metathesis-derived 15-member macrocycles as Grb2 SH2 domain-binding tetrapeptide mimetics.
The Journal of organic chemistry 2007;72(25):9635-42.
2007: Giubellino Alessio; Gao Yang; Lee Sunmin; Lee Min-Jung; Vasselli James R; Medepalli Sampath; Trepel Jane B; Burke Terrence R; Bottaro Donald P
Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.
Cancer research 2007;67(13):6012-6.
2007: Kang Sang-Uk; Choi Won Jun; Oishi Shinya; Lee Kyeong; Karki Rajeshri G; Worthy Karen M; Bindu Lakshman K; Nicklaus Marc C; Fisher Robert J; Burke Terrence R
Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides.
Journal of medicinal chemistry 2007;50(8):1978-82.
2007: Johnson Allison A; Marchand Christophe; Patil Sachindra S; Costi Roberta; Di Santo Roberto; Burke Terrence R; Pommier Yves
Probing HIV-1 integrase inhibitor binding sites with position-specific integrase-DNA cross-linking assays.
Molecular pharmacology 2007;71(3):893-901.
2007: Liu Fa; Worthy Karen M; Bindu Lakshman; Giubellino Alessio; Bottaro Donald P; Fisher Robert J; Burke Terrence R
Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.
Organic & biomolecular chemistry 2007;5(2):367-72.
2006: Zhao Xue Zhi; Semenova Elena A; Liao Chenzhong; Nicklaus Marc; Pommier Yves; Burke Terrence R
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands.
Bioorganic & medicinal chemistry 2006;14(23):7816-25.
2006: Liu Fa; Stephen Andrew G; Adamson Catherine S; Gousset Karine; Aman M Javad; Freed Eric O; Fisher Robert J; Burke Terrence R
Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: application to the preparation of Tsg101-directed HIV-1 budding antagonists.
Organic letters 2006;8(22):5165-8.
2006: Baba Masaya; Hong Seung-Beom; Sharma Nirmala; Warren Michelle B; Nickerson Michael L; Iwamatsu Akihiro; Esposito Dominic; Gillette William K; Hopkins Ralph F; Hartley James L; Furihata Mutsuo; Oishi Shinya; Zhen Wei; Burke Terrence R; Linehan W Marston; Schmidt Laura S; Zbar Berton
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15552-7.
2006: Jiang Sheng; Li Peng; Peach Megan L; Bindu Lakshman; Worthy Karen W; Fisher Robert J; Burke Terrence R; Nicklaus Marc; Roller Peter P
Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
Biochemical and biophysical research communications 2006;349(2):497-503.
2006: Johnson Allison A; Sayer Jane M; Yagi Haruhiko; Patil Sachindra S; Debart Françoise; Maier Martin A; Corey David R; Vasseur Jean-Jacques; Burke Terrence R; Marquez Victor E; Jerina Donald M; Pommier Yves
Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
The Journal of biological chemistry 2006;281(43):32428-38.
2006: Choi Won Jun; Shi Zhen-Dan; Worthy Karen M; Bindu Lakshman; Karki Rajeshri G; Nicklaus Marc C; Fisher Robert J; Burke Terrence R
Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.
Bioorganic & medicinal chemistry letters 2006;16(20):5265-9.
2006: Al-Mawsawi Laith Q; Fikkert Valery; Dayam Raveendra; Witvrouw Myriam; Burke Terrence R; Borchers Christoph H; Neamati Nouri
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10080-5.
2006: Li Min; Mizuuchi Michiyo; Burke Terrence R; Craigie Robert
Retroviral DNA integration: reaction pathway and critical intermediates.
The EMBO journal 2006;25(6):1295-304.
2006: Dharmawardana Pathirage G; Peruzzi Benedetta; Giubellino Alessio; Burke Terrence R; Bottaro Donald P
Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy.
Anti-cancer drugs 2006;17(1):13-20.
2006: Johnson Allison A; Santos Webster; Pais Godwin C G; Marchand Christophe; Amin Ronak; Burke Terrence R; Verdine Gregory; Pommier Yves
Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.
The Journal of biological chemistry 2006;281(1):461-7.
2006: Burke Terrence R
Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.
Current topics in medicinal chemistry 2006;6(14):1465-71.
2005: Phan Jason; Shi Zhen-Dan; Burke Terrence R; Waugh David S
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain.
Journal of molecular biology 2005;353(1):104-15.
2005: Lee Kyeong; Boovanahalli Shanthaveerappa K; Nam Ky-Youb; Kang Sang-Uk; Lee Mijeoung; Phan Jason; Wu Li; Waugh David S; Zhang Zhong-Yin; No Kyoung Tai; Lee Jung Jun; Burke Terrence R
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(18):4037-42.
2005: Kang Sang-Uk; Worthy Karen M; Bindu Lakshman K; Zhang Manchao; Yang Dajun; Fisher Robert J; Burke Terrence R
Design and synthesis of 4-(alpha-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 src-homology 2 (Grb2 SH2) domain-binding peptides.
Journal of medicinal chemistry 2005;48(16):5369-72.
2005: Plasencia Carmen; Dayam Raveendra; Wang Qingcai; Pinski Jacek; Burke Terrence R; Quinn David I; Neamati Nouri
Discovery and preclinical evaluation of a novel class of small-molecule compounds in hormone-dependent and -independent cancer cell lines.
Molecular cancer therapeutics 2005;4(7):1105-13.
2005: Shi Zhen-Dan; Liu Hongpeng; Zhang Manchao; Worthy Karen M; Bindu Lakshman; Yang Dajun; Fisher Robert J; Burke Terrence R
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity.
Bioorganic & medicinal chemistry 2005;13(13):4200-8.
2005: Kang Sang-Uk; Shi Zhen-Dan; Worthy Karen M; Bindu Lakshman K; Dharmawardana Pathirage G; Choyke Sarah J; Bottaro Donald P; Fisher Robert J; Burke Terrence R
Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.
Journal of medicinal chemistry 2005;48(12):3945-8.
2005: Shi Zhen-Dan; Karki Rajeshri G; Worthy Karen M; Bindu Lakshman K; Nicklaus Marc C; Fisher Robert J; Burke Terrence R
Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.
Chemistry & biodiversity 2005;2(4):447-56.
2005: Oishi Shinya; Karki Rajeshri G; Shi Zhen-Dan; Worthy Karen M; Bindu Lakshman; Chertov Oleg; Esposito Dominic; Frank Peter; Gillette William K; Maderia Melissa; Hartley James; Nicklaus Marc C; Barchi Joseph J; Fisher Robert J; Burke Terrence R
Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.
Bioorganic & medicinal chemistry 2005;13(7):2431-8.
2005: Oishi Shinya; Shi Zhen-Dan; Worthy Karen M; Bindu Lakshman K; Fisher Robert J; Burke Terrence R
Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles.
Chembiochem : a European journal of chemical biology 2005;6(4):668-74.
2005: Shi Zhen-Dan; Karki Rajeshri G; Oishi Shinya; Worthy Karen M; Bindu Lakshman K; Dharmawardana Pathirage G; Nicklaus Marc C; Bottaro Donald P; Fisher Robert J; Burke Terrence R
Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.
Bioorganic & medicinal chemistry letters 2005;15(5):1385-8.
2005: Oishi Shinya; Karki Rajeshri G; Kang Sang-Uk; Wang Xiangzhu; Worthy Karen M; Bindu Lakshman K; Nicklaus Marc C; Fisher Robert J; Burke Terrence R
Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
Journal of medicinal chemistry 2005;48(3):764-72.
2005: Yao Zhu-Jun; Lee Kyeong; Burke Terrence R
Incorporation of phosphotyrosyl mimetic 4-(phosphonodifluoromethyl)phenylalanine (F2Pmp) into signal transduction-directed peptides.
Methods in molecular biology (Clifton, N.J.) 2005;298():91-103.
2004: Karki Rajeshri G; Tang Yun; Burke Terrence R; Nicklaus Marc C
Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.
Journal of computer-aided molecular design 2004;18(12):739-60.
2004: Soriano Jesus V; Liu Ningfei; Gao Yang; Yao Zhu-Jun; Ishibashi Toshio; Underhill Charles; Burke Terrence R; Bottaro Donald P
Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists.
Molecular cancer therapeutics 2004;3(10):1289-99.
2004: Shkriabai Nick; Patil Sachindra S; Hess Sonja; Budihas Scott R; Craigie Robert; Burke Terrence R; Le Grice Stuart F J; Kvaratskhelia Mamuka
Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6894-9.
2004: Kang Sang Uk; Gao Yang; Wu Li; Zhang Zhong-Yin; Burke Terrence R
Enantioselective synthesis of (S)-3-carboxy-4-((carboxy)difluoromethyl)phenylalanine in protected form and its incorporation into a PTP-1B-directed tripeptide.
Chemistry & biodiversity 2004;1(4):626-33.
2004: Shi Zhen-Dan; Wei Chang-Qing; Lee Kyeong; Liu Hongpeng; Zhang Manchao; Araki Toshiyuki; Roberts Lindsey R; Worthy Karen M; Fisher Robert J; Neel Benjamin G; Kelley James A; Yang Dajun; Burke Terrence R
Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.
Journal of medicinal chemistry 2004;47(8):2166-9.
2004: Svarovskaia Evguenia S; Barr Rebekah; Zhang Xuechun; Pais Godwin C G; Marchand Christophe; Pommier Yves; Burke Terrence R; Pathak Vinay K
Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.
Journal of virology 2004;78(7):3210-22.
2004: Zhang Xuechun; Marchand Christophe; Pommier Yves; Burke Terrence R
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Bioorganic & medicinal chemistry letters 2004;14(5):1205-7.
2004: Shi Zhen-Dan; Lee Kyeong; Wei Chang-Qing; Roberts Lindsey R; Worthy Karen M; Fisher Robert J; Burke Terrence R
Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity.
Journal of medicinal chemistry 2004;47(4):788-91.
2003: Phan Jason; Lee Kyeong; Cherry Scott; Tropea Joseph E; Burke Terrence R; Waugh David S
High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide.
Biochemistry 2003;42(45):13113-21.
2003: Shi Zhen-Dan; Lee Kyeong; Liu Hongpeng; Zhang Manchao; Roberts Lindsey R; Worthy Karen M; Fivash Matthew J; Fisher Robert J; Yang Dajun; Burke Terrence R
A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity.
Biochemical and biophysical research communications 2003;310(2):378-83.
2003: Liu Ding-Guo; Gao Yang; Voigt Johannes H; Lee Kyeong; Nicklaus Marc C; Wu Li; Zhang Zhong-Yin; Burke Terrence R
Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration.
Bioorganic & medicinal chemistry letters 2003;13(18):3005-7.
2003: Marchand Christophe; Johnson Allison A; Karki Rajeshri G; Pais Godwin C G; Zhang Xuechun; Cowansage Kiriana; Patel Tapan A; Nicklaus Marc C; Burke Terrence R; Pommier Yves
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
Molecular pharmacology 2003;64(3):600-9.
2003: Lee Kyeong; Gao Yang; Yao Zhu-Jun; Phan Jason; Wu Li; Liang Jiao; Waugh David S; Zhang Zhong-Yin; Burke Terrence R
Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase.
Bioorganic & medicinal chemistry letters 2003;13(15):2577-81.
2003: Burke Terrence R; Lee Kyeong
Phosphotyrosyl mimetics in the development of signal transduction inhibitors.
Accounts of chemical research 2003;36(6):426-33.
2003: Lee Kyeong; Zhang Manchao; Liu Hongpeng; Yang Dajun; Burke Terrence R
Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.
Journal of medicinal chemistry 2003;46(13):2621-30.
2003: Zhang Xuechun; Pais Godwin C G; Svarovskaia Evguenia S; Marchand Christophe; Johnson Allison A; Karki Rajeshri G; Nicklaus Marc C; Pathak Vinay K; Pommier Yves; Burke Terrence R
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1215-9.
2003: Wei Chang-Qing; Gao Yang; Lee Kyeong; Guo Ribo; Li Bihua; Zhang Manchao; Yang Dajun; Burke Terrence R
Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.
Journal of medicinal chemistry 2003;46(2):244-54.
2002: Neamati Nouri; Lin Zhaiwei; Karki Rajeshri G; Orr Ann; Cowansage Kiriana; Strumberg Dirk; Pais Godwin C G; Voigt Johannes H; Nicklaus Marc C; Winslow Heather E; Zhao He; Turpin Jim A; Yi Jizu; Skalka Anna Marie; Burke Terrence R; Pommier Yves
Metal-dependent inhibition of HIV-1 integrase.
Journal of medicinal chemistry 2002;45(26):5661-70.
2002: Lee Kyeong; Zhang Manchao; Yang Dajun; Burke Terrence R
Design and synthesis of a beta-amino phosphotyrosyl mimetic suitably protected for peptide synthesis.
Bioorganic & medicinal chemistry letters 2002;12(23):3399-401.
2002: Pluymers Wim; Pais Godwin; Van Maele Bénédicte; Pannecouque Christophe; Fikkert Valery; Burke Terrence R; De Clercq Erik; Witvrouw Myriam; Neamati Nouri; Debyser Zeger
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Antimicrobial agents and chemotherapy 2002;46(10):3292-7.
2002: Wei Chang-Qing; Li Bihua; Guo Ribo; Yang Dajun; Burke Terrence R
Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands.
Bioorganic & medicinal chemistry letters 2002;12(19):2781-4.
2002: Pais Godwin C G; Zhang Xuechun; Marchand Christophe; Neamati Nouri; Cowansage Kiriana; Svarovskaia Evguenia S; Pathak Vinay K; Tang Yun; Nicklaus Marc; Pommier Yves; Burke Terrence R
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2002;45(15):3184-94.
2002: Marchand Christophe; Zhang Xuechun; Pais Godwin C G; Cowansage Kiriana; Neamati Nouri; Burke Terrence R; Pommier Yves
Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.
The Journal of biological chemistry 2002;277(15):12596-603.
2002: Liu Ding-Guo; Gao Yang; Wang Xiangzhu; Kelley James A; Burke Terrence R
Enantioselective synthesis of N(alpha)-Fmoc protected (2S,3R)-3-phenylpipecolic acid. A constrained phenylalanine analogue suitably protected for solid-phase peptide synthesis.
The Journal of organic chemistry 2002;67(5):1448-52.
2002: Melek Meni; Jones Jessica M; O'Dea Mary H; Pais Godwin; Burke Terrence R; Pommier Yves; Neamati Nouri; Gellert Martin
Effect of HIV integrase inhibitors on the RAG1/2 recombinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):134-7.
2001: Gao Y; Voigt J; Zhao H; Pais G C; Zhang X; Wu L; Zhang Z Y; Burke T R
Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.
Journal of medicinal chemistry 2001;44(18):2869-78.
2001: Gao Y; Voigt J; Wu J X; Yang D; Burke T R
Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.
Bioorganic & medicinal chemistry letters 2001;11(14):1889-92.
2001: Zhang X; Neamati N; Lee Y K; Orr A; Brown R D; Whitaker N; Pommier Y; Burke T R
Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase.
Bioorganic & medicinal chemistry 2001;9(7):1649-57.
2001: Burke T R; Yao Z J; Gao Y; Wu J X; Zhu X; Luo J H; Guo R; Yang D
N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding.
Bioorganic & medicinal chemistry 2001;9(6):1439-45.
2001: Gao Y; Wei C Q; Burke T R
Olefin metathesis in the design and synthesis of a globally constrained Grb2 SH2 domain inhibitor.
Organic letters 2001;3(11):1617-20.
2001: Burke T R; Yao Z J; Ye B; Miyoshi K; Otaka A; Wu L; Zhang Z Y
Phospho-Azatyrosine, a less effective protein-tyrosine phosphatase substrate than phosphotyrosine.
Bioorganic & medicinal chemistry letters 2001;11(10):1265-8.
2001: Atabey N; Gao Y; Yao Z J; Breckenridge D; Soon L; Soriano J V; Burke T R; Bottaro D P
Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions.
The Journal of biological chemistry 2001;276(17):14308-14.
2001: Burke T R; Yao Z J; Liu D G; Voigt J; Gao Y
Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors.
Biopolymers 2001;60(1):32-44.
2000: Burke T R; Liu D G; Gao Y
Use of a Heck reaction for the synthesis of a new alpha-azido phosphotyrosyl mimetic suitably protected for peptide synthesis.
The Journal of organic chemistry 2000;65(19):6288-91.
2000: Zhang X; Lee Y K; Kelley J A; Burke T R
Preparation of aryl isothiocyanates via protected phenylthiocarbamates and application to the synthesis of caffeic acid (4-isothiocyanato)phenyl ester.
The Journal of organic chemistry 2000;65(19):6237-40.
2000: Pluymers W; Neamati N; Pannecouque C; Fikkert V; Marchand C; Burke T R; Pommier Y; Schols D; De Clercq E; Debyser Z; Witvrouw M
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Gao Y; Wu L; Luo J H; Guo R; Yang D; Zhang Z Y; Burke T R
Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains.
Bioorganic & medicinal chemistry letters 2000;10(9):923-7.
2000: Gao Y; Luo J; Yao Z J; Guo R; Zou H; Kelley J; Voigt J H; Yang D; Burke T R
Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic.
Journal of medicinal chemistry 2000;43(5):911-20.
1999: Long Y Q; Yao Z J; Voigt J H; Lung F D; Luo J H; Burke T R; King C R; Yang D; Roller P P
Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain.
Biochemical and biophysical research communications 1999;264(3):902-8.
1999: Lin Z; Neamati N; Zhao H; Kiryu Y; Turpin J A; Aberham C; Strebel K; Kohn K; Witvrouw M; Pannecouque C; Debyser Z; De Clercq E; Rice W G; Pommier Y; Burke T R
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Burke T R; Luo J; Yao Z J; Gao Y; Zhao H; Milne G W; Guo R; Voigt J H; King C R; Yang D
Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(3):347-52.
1999: Yao Z J; King C R; Cao T; Kelley J; Milne G W; Voigt J H; Burke T R
Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.
Journal of medicinal chemistry 1999;42(1):25-35.
1998: Yao Z J; Ye B; Wu X W; Wang S; Wu L; Zhang Z Y; Burke T R
Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors.
Bioorganic & medicinal chemistry 1998;6(10):1799-810.
1998: Roller P P; Wu L; Zhang Z Y; Burke T R
Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT).
Bioorganic & medicinal chemistry letters 1998;8(16):2149-50.
1998: Neamati N; Hong H; Owen J M; Sunder S; Winslow H E; Christensen J L; Zhao H; Burke T R; Milne G W; Pommier Y
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
Journal of medicinal chemistry 1998;41(17):3202-9.
1998: Burke T R; Zhang Z Y
Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery.
Biopolymers 1998;47(3):225-41.
1997: Oligino L; Lung F D; Sastry L; Bigelow J; Cao T; Curran M; Burke T R; Wang S; Krag D; Roller P P; King C R
Nonphosphorylated peptide ligands for the Grb2 Src homology 2 domain.
The Journal of biological chemistry 1997;272(46):29046-52.
1997: Zhao H; Neamati N; Mazumder A; Sunder S; Pommier Y; Burke T R
Arylamide inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(8):1186-94.
1997: Zhao H; Neamati N; Sunder S; Hong H; Wang S; Milne G W; Pommier Y; Burke T R
Hydrazide-containing inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1997;40(6):937-41.
1997: Hong H; Neamati N; Wang S; Nicklaus M C; Mazumder A; Zhao H; Burke T R; Pommier Y; Milne G W
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
Journal of medicinal chemistry 1997;40(6):930-6.
1997: Neamati N; Mazumder A; Zhao H; Sunder S; Burke T R; Schultz R J; Pommier Y
Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.
Antimicrobial agents and chemotherapy 1997;41(2):385-93.
1997: Akamatsu M; Roller P P; Chen L; Zhang Z Y; Ye B; Burke T R
Potent inhibition of protein-tyrosine phosphatase by phosphotyrosine-mimic containing cyclic peptides.
Bioorganic & medicinal chemistry 1997;5(1):157-63.
1997: Zhao H; Neamati N; Hong H; Mazumder A; Wang S; Sunder S; Milne G W; Pommier Y; Burke T R
Coumarin-based inhibitors of HIV integrase.
Journal of medicinal chemistry 1997;40(2):242-9.
1996: Burke T R; Ye B; Yan X; Wang S; Jia Z; Chen L; Zhang Z Y; Barford D
Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
Biochemistry 1996;35(50):15989-96.
1996: Stanwell C; Ye B; Yuspa S H; Burke T R
Cell protein cross-linking by erbstatin and related compounds.
Biochemical pharmacology 1996;52(3):475-80.
1996: Mazumder A; Wang S; Neamati N; Nicklaus M; Sunder S; Chen J; Milne G W; Rice W G; Burke T R; Pommier Y
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
Journal of medicinal chemistry 1996;39(13):2472-81.
1996: Burke T R; Ye B; Akamatsu M; Ford H; Yan X; Kole H K; Wolf G; Shoelson S E; Roller P P
4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.
Journal of medicinal chemistry 1996;39(5):1021-7.
1996: Barchi J J; Nomizu M; Otaka A; Roller P P; Burke T R
Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase.
Biopolymers 1996;38(2):191-208.
1995: Stanwell C; Burke T R; Yuspa S H
The erbstatin analogue methyl 2,5-dihydroxycinnamate cross-links proteins and is cytotoxic to normal and neoplastic epithelial cells by a mechanism independent of tyrosine kinase inhibition.
Cancer research 1995;55(21):4950-6.
1995: Chen L; Wu L; Otaka A; Smyth M S; Roller P P; Burke T R; den Hertog J; Zhang Z Y
Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?
Biochemical and biophysical research communications 1995;216(3):976-84.
1995: Kole H K; Smyth M S; Russ P L; Burke T R
Phosphonate inhibitors of protein-tyrosine and serine/threonine phosphatases.
The Biochemical journal 1995;311 ( Pt 3)():1025-31.
1995: Ye B; Akamatsu M; Shoelson S E; Wolf G; Giorgetti-Peraldi S; Yan X; Roller P P; Burke T R
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides.
Journal of medicinal chemistry 1995;38(21):4270-5.
1995: Burke T R; Fesen M R; Mazumder A; Wang J; Carothers A M; Grunberger D; Driscoll J; Kohn K; Pommier Y
Hydroxylated aromatic inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1995;38(21):4171-8.
1995: Kole H K; Akamatsu M; Ye B; Yan X; Barford D; Roller P P; Burke T R
Protein-tyrosine phosphatase inhibition by a peptide containing the phosphotyrosyl mimetic, L-O-malonyltyrosine.
Biochemical and biophysical research communications 1995;209(3):817-22.
1995: Burke T R; Barchi J J; George C; Wolf G; Shoelson S E; Yan X
Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors.
Journal of medicinal chemistry 1995;38(8):1386-96.
1994: Burke T R; Kole H K; Roller P P
Potent inhibition of insulin receptor dephosphorylation by a hexamer peptide containing the phosphotyrosyl mimetic F2Pmp.
Biochemical and biophysical research communications 1994;204(1):129-34.
1994: Burke T R; Nomizu M; Otaka A; Smyth M S; Roller P P; Case R D; Wolf G; Shoelson S E
Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding.
Biochemical and biophysical research communications 1994;201(3):1148-53.
1994: Burke T R; Smyth M S; Otaka A; Nomizu M; Roller P P; Wolf G; Case R; Shoelson S E
Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.
Biochemistry 1994;33(21):6490-4.
1994: Burke T R
Protein-tyrosine kinases: potential targets for anticancer drug development.
Stem cells (Dayton, Ohio) 1994;12(1):1-6.
1993: Smyth M S; Stefanova I; Horak I D; Burke T R
Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors.
Journal of medicinal chemistry 1993;36(20):3015-20.
1993: Smyth M S; Stefanova I; Hartmann F; Horak I D; Osherov N; Levitzki A; Burke T R
Non-amine based analogues of lavendustin A as protein-tyrosine kinase inhibitors.
Journal of medicinal chemistry 1993;36(20):3010-4.
1993: Burke T R; Lim B; Marquez V E; Li Z H; Bolen J B; Stefanova I; Horak I D
Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.
Journal of medicinal chemistry 1993;36(4):425-32.
1992: Nicklaus M C; Milne G W; Burke T R
QSAR of conformationally flexible molecules: comparative molecular field analysis of protein-tyrosine kinase inhibitors.
Journal of computer-aided molecular design 1992;6(5):487-504.
1991: Burke T R; Li Z H; Bolen J B; Marquez V E
Phosphonate-containing inhibitors of tyrosine-specific protein kinases.
Journal of medicinal chemistry 1991;34(5):1577-81.
1991: Burke T R; Li Z H; Bolen J B; Chapekar M; Gang Y; Glazer R I; Rice K C; Marquez V E
Examination of the possible mediation of antineoplastic effects of opiates through the inhibition of tyrosine-specific protein kinases.
Biochemical pharmacology 1991;41(10):R17-20.

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