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Linda Burkly

Research Profile

Chemicals & Drugs

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Juan A Moreno; Begoña Muñoz-García; Luis Ortega; Cristina Sastre; Linda C Burkly; Jesús Egido; Julio Madrigal-Matute; Jose Luis Martín-Ventura; Luis M Blanco-Colio
HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes.
Jianru Shi; Lihe Su; Yiling Qiu; Michael Bauer; Linda C Burkly; Xin Cao; Jian Guan; Mohit Jain; Bingbing Jiang; Daniel P Kelly; Teresa C Leone; Ronglih Liao
PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.
Yumin Xia; Ping Wu; Maria Abadi; Anna Broder; Linda C Burkly; Sean R Campbell; Leal Herlitz; Jennifer S Michaelson; Chaim Putterman
Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis.

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All Publications

2013: Juan A Moreno; Begoña Muñoz-García; Luis Ortega; Cristina Sastre; Linda C Burkly; Jesús Egido; Julio Madrigal-Matute; Jose Luis Martín-Ventura; Luis M Blanco-Colio
HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(3):612-20.
2013: Jianru Shi; Lihe Su; Yiling Qiu; Michael Bauer; Linda C Burkly; Xin Cao; Jian Guan; Mohit Jain; Bingbing Jiang; Daniel P Kelly; Teresa C Leone; Ronglih Liao
PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.
PloS one 2013;8(1):e54054.
2012: Yumin Xia; Ping Wu; Maria Abadi; Anna Broder; Linda C Burkly; Sean R Campbell; Leal Herlitz; Jennifer S Michaelson; Chaim Putterman
Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis.
Clinical immunology (Orlando, Fla.) 2012;145(2):108-21.
2012: Jennifer S Michaelson; Linda C Burkly; Nicolas Wisniacki; Chaim Putterman
Role of TWEAK in lupus nephritis: a bench-to-bedside review.
Journal of autoimmunity 2012;39(3):130-42.
2012: Taeko Dohi; Linda C Burkly
The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases.
Journal of leukocyte biology 2012;92(2):265-79.
2011: Rei Kawashima; Fumio Konishi; Oki Miyake; Toshihiko Okada; Tomoyuki Oshio; Yukio Saito; Aoi Son; Suzanne Szak; Ping Wu; Motomi Yamazaki; Hideaki Yano; Teruki Hagiwara; Kyoko Inagaki-Ohara; Yuki I Kawamura; Yutaka J Kawamura; Linda C Burkly; Taeko Dohi
Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis.
Gastroenterology 2011;141(6):2119-2129.e8.
2011: Linda C Burkly; Jennifer S Michaelson; Timothy S Zheng
TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses.
Immunological reviews 2011;244(1):99-114.
2011: Douglas R Kennedy; Brian J Hartnett; Jeffrey S Kennedy; William Vernau; Peter F Moore; Thomas M O'Malley; Linda C Burkly; Paula S Henthorn; Peter J Felsburg
Ex vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency and the development of a thymic T cell lymphoma.
Veterinary immunology and immunopathology 2011;142(1-2):36-48.
2011: Jennifer S Michaelson; Michael Parr; Pascal Schneider; Lihe Su; Laure Wille; Kathleen Wortham; Rebecca Kelly; You Li; Aldo Amatucci; Lisa Berquist; Linda C Burkly; Sandy Cho; Eric S Day; Ellen Garber; Yen-Ming Hsu; Ingrid B J K Joseph
Development of an Fn14 agonistic antibody as an anti-tumor agent.
mAbs 2011;3(4):362-75.
2011: Linda C Burkly; Taeko Dohi
The TWEAK/Fn14 pathway in tissue remodeling: for better or for worse.
Advances in experimental medicine and biology 2011;691():305-22.
2011: Linda C Burkly
Introductory words about TWEAK/Fn14.
Advances in experimental medicine and biology 2011;691():275-7.
2011: Begoña Muñoz-García; Julio Madrigal-Matute; Juan A Moreno; Jose Luis Martin-Ventura; Oscar López-Franco; Cristina Sastre; Luis Ortega; Linda C Burkly; Jesús Egido; Luis M Blanco-Colio
TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells.
Cardiovascular research 2011;89(1):225-33.
2009: Begoña Muñoz-García; Juan Antonio Moreno; Oscar López-Franco; Ana Belén Sanz; Jose Luis Martín-Ventura; Julia Blanco; Aniela Jakubowski; Linda C Burkly; alberto ortiz; Jesús Egido; Luis M Blanco-Colio
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(12):2061-8.
2009: Kitty Schapira; Linda C Burkly; Timothy S Zheng; Ping Wu; Mathijs Groeneweg; Mat Rousch; Mark M Kockx; Mat J A P Daemen; Sylvia Heeneman
Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(12):2021-7.
2009: Alberto Molano; Payal Lakhani; Adi Aran; Linda C Burkly; Jennifer S Michaelson; Chaim Putterman
TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis.
Immunology letters 2009;125(2):119-28.
2009: Mohit Jain; Aniela Jakubowski; Lei Cui; Jianru Shi; Lihe Su; Michael Bauer; Jian Guan; Chee Chew Lim; Yoshiro Naito; Jeffrey S Thompson; Flora Sam; Christine Ambrose; Michael Parr; Thomas Crowell; John M Lincecum; Monica Z Wang; Yen-Ming Hsu; Timothy S Zheng; Jennifer S Michaelson; Ronglih Liao; Linda C Burkly
A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure.
Circulation 2009;119(15):2058-68.
2009: Hua-Xin Gao; Sean R Campbell; Linda C Burkly; Aniela Jakubowski; Irene Jarchum; Bernhard Banas; Moin A Saleem; Peter W Mathieson; Joan W Berman; Jennifer S Michaelson; Chaim Putterman
TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells.
Cytokine 2009;46(1):24-35.
2009: Taeko Dohi; Anna Borodovsky; Ping Wu; Jeffrey R Shearstone; Rei Kawashima; Laura Runkel; Luis Rajman; Xingwen Dong; Martin L Scott; Jennifer S Michaelson; Aniela Jakubowski; Linda C Burkly
TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.
Gastroenterology 2009;136(3):912-23.
2009: Noa Schwartz; Tamar Rubinstein; Linda C Burkly; Christopher E Collins; Irene Blanco; Lihe Su; Bernard Hojaili; Meggan Mackay; Cynthia Aranow; William Stohl; Brad H Rovin; Jennifer S Michaelson; Chaim Putterman
Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.
Arthritis research & therapy 2009;11(5):R143.
2009: Jennifer S Michaelson; Linda C Burkly
Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway.
Results and problems in cell differentiation 2009;49():145-60.
2008: Timothy S Zheng; Linda C Burkly
No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies.
Journal of leukocyte biology 2008;84(2):338-47.
2008: Bhanu P Pappu; Anna Borodovsky; Timothy S Zheng; Xuexian Yang; Ping Wu; Xingwen Dong; Shawn Weng; Beth Browning; Martin L Scott; Li Ma; Lihe Su; Qiang Tian; Pascal Schneider; Richard A Flavell; Chen Dong; Linda C Burkly
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
The Journal of experimental medicine 2008;205(5):1049-62.
2008: Heather A Iocca; Sheila R Plant; Ying Wang; Laura Runkel; Brian P O'Connor; Emma T Lundsmith; Kyungmin Hahm; Hendrik W van Deventer; Linda C Burkly; Jenny P-Y Ting
TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model.
Journal of neuroimmunology 2008;194(1-2):97-106.
2007: Zeguo Zhao; Linda C Burkly; Sean Campbell; Noa Schwartz; Alberto Molano; Arpita Choudhury; Robert A Eisenberg; Jennifer S Michaelson; Chaim Putterman
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7949-58.
2007: C A Hamill; J S Michaelson; Kyungmin Hahm; Linda C Burkly; John A Kessler
Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells.
Journal of neuroscience research 2007;85(16):3535-44.
2007: Linda C Burkly; Jennifer S Michaelson; Kyungmin Hahm; Aniela Jakubowski; Timothy S Zheng
TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease.
Cytokine 2007;40(1):1-16.
2007: Linda Beckers; Sylvia Heeneman; L Wang; Linda C Burkly; M M J Rousch; Nicholas O Davidson; Marion J J Gijbels; Menno de Winther; Mat J A P Daemen; Esther Lutgens
Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages.
The Journal of pathology 2007;212(4):420-8.
2007: Xiaohui Zhang; Jeffrey A Winkles; Maria Carolina Gongora; Rohini Polavarapu; Jennifer S Michaelson; Kyungmin Hahm; Linda C Burkly; Meyer Friedman; Xiao-Jiang Li; Manuel Yepes
TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(3):534-44.
2006: Mahasweta Girgenrath; Shawn Weng; Christine A Kostek; Beth Browning; Monica Wang; Sharron A N Brown; Jeffrey A Winkles; Jennifer S Michaelson; Normand E Allaire; Pascal Schneider; Martin L Scott; Yen-Ming Hsu; Hideo Yagita; Richard A Flavell; Jeffrey Boone Miller; Linda C Burkly; Timothy S Zheng
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
The EMBO journal 2006;25(24):5826-39.
2006: Noa Schwartz; Lihe Su; Linda C Burkly; Meggan Mackay; Cynthia Aranow; Maria Kollaros; Jennifer S Michaelson; Brad H Rovin; Chaim Putterman
Urinary TWEAK and the activity of lupus nephritis.
Journal of autoimmunity 2006;27(4):242-50.
2006: Nhan L Tran; Wendy S McDonough; Benjamin A Savitch; Shannon P Fortin; Jeffrey A Winkles; Marc Symons; Mitsutoshi Nakada; Heather Cunliffe; Galen Hostetter; Dominique Hoelzinger; Jessica L Rennert; Jennifer S Michaelson; Linda C Burkly; Christopher A Lipinski; Joseph C Loftus; Luigi Mariani; Michael Berens
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.
Cancer research 2006;66(19):9535-42.
2006: Stuart J Perper; Beth Browning; Linda C Burkly; Shawn Weng; Cindy Gao; Keith Giza; Lihe Su; Leticia Tarilonte; Thomas Crowell; Luis Rajman; Laura Runkel; Martin Scott; Gerald J Atkins; David M Findlay; Timothy S Zheng; Henry Hess
TWEAK is a novel arthritogenic mediator.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2610-20.
2006: Yuzhu Tang; Elzbieta A Swietlicki; Shujun Jiang; Kimberly Buhman; Nicholas O Davidson; Linda C Burkly; Marc S Levin; Deborah C Rubin
Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1280-8.
2006: Sean Campbell; Linda C Burkly; Hua-Xin Gao; Joan W Berman; Lihe Su; Beth Browning; Timothy Zheng; Lena Schiffer; Jennifer S Michaelson; Chaim Putterman
Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1889-98.
2005: Sophie Desplat-Jégo; Rita Creidy; Simone Varriale; Normand E Allaire; Yi Luo; Dominique Bernard; Kyungmin Hahm; Linda C Burkly; José Boucraut
Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.) 2005;117(1):15-23.
2005: Aniela Jakubowski; Christine Ambrose; Michael Parr; John M Lincecum; Monica Z Wang; Timothy S Zheng; Beth Browning; Jennifer S Michaelson; Manfred Baetscher; Manfred Baestcher; Bruce Wang; D Montgomery Bissell; Linda C Burkly
TWEAK induces liver progenitor cell proliferation.
The Journal of clinical investigation 2005;115(9):2330-40.
2005: Jennifer S Michaelson; Sandy Cho; Beth Browning; Timothy S Zheng; John M Lincecum; Monica Z Wang; Yen-Ming Hsu; Linda C Burkly
Tweak induces mammary epithelial branching morphogenesis.
Oncogene 2005;24(16):2613-24.
2005: Dian L Olson; Linda C Burkly; Diane R Leone; Brian M Dolinski; Roy R Lobb
Anti-alpha4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model.
Molecular cancer therapeutics 2005;4(1):91-9.
2004: Kimberly Buhman; Li Chun Wang; Yuzhu Tang; Elzbieta A Swietlicki; Susan Kennedy; Yan Xie; Zhong-Yi Liu; Linda C Burkly; Marc S Levin; Deborah C Rubin; Nicholas O Davidson
Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain.
The Journal of nutrition 2004;134(11):2979-84.
2004: Janine L Ferrant; Christopher D Benjamin; Anne H Cutler; Susan L Kalled; Yen-Ming Hsu; Ellen A Garber; Donna M Hess; Renee I Shapiro; Norma S Kenyon; David M Harlan; Allan D Kirk; Linda C Burkly; Frederick R Taylor
The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
International immunology 2004;16(11):1583-94.
2004: Ioana Potrovita; Wen Zhang; Linda C Burkly; Kyungmin Hahm; John Lincecum; Monica Z Wang; Martin H Maurer; Moritz Rossner; Armin Schneider; Markus Schwaninger
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(38):8237-44.
2004: Sean Campbell; Jennifer S Michaelson; Linda C Burkly; Chaim Putterman
The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity.
Frontiers in bioscience : a journal and virtual library 2004;9():2273-84.
2004: Lex Nagelkerken; Inge Haspels; Wouter Van Rijs; Bep Blauw; Janine L Ferrant; Donna M Hess; Ellen A Garber; Frederick R Taylor; Linda C Burkly
FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):993-9.
2003: He Xu; Eric Elster; Patrick J Blair; Linda C Burkly; Douglas K Tadaki; David M Harlan; Allan D Kirk
Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(11):1350-4.
2003: Pascal Schneider; Dian Olson; Aubry Tardivel; Beth Browning; Alexey A Lugovskoy; DaHai Gong; Max Dobles; Sylvie Hertig; Kay Hofmann; Herman van Vlijmen; Yen-Ming Hsu; Linda C Burkly; Jürg Tschopp; Timothy S Zheng
Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
The Journal of biological chemistry 2003;278(7):5444-54.
2002: Sean P Montgomery; He Xu; Douglas K Tadaki; Abbie Celniker; Linda C Burkly; Justin D Berning; Francis Cruzata; Eric Elster; Gary Gray; Robert L Kampen; S John Swanson; David M Harlan; Allan D Kirk
Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation.
Transplantation 2002;74(10):1365-9.
2002: He Xu; Douglas K Tadaki; Eric Elster; Linda C Burkly; Justin D Berning; Francis Cruzata; Robert L Kampen; Sean P Montgomery; Noelle B Patterson; David M Harlan; Allan D Kirk
Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates.
Transplantation 2002;74(7):940-3.
2002: Li Chun Wang; Fatiha Nassir; Zhong-Ying Liu; Leona Ling; Frank Kuo; Thomas Crowell; Dian Olson; Nicholas O Davidson; Linda C Burkly
Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice.
Gastroenterology 2002;122(2):469-82.
2002: Aniela Jakubowski; Beth Browning; Matvey Lukashev; Irene Sizing; Jeffrey S Thompson; Christopher D Benjamin; Yen-Ming Hsu; Christine Ambrose; Timothy S Zheng; Linda C Burkly
Dual role for TWEAK in angiogenic regulation.
Journal of cell science 2002;115(Pt 2):267-74.
2001: He Xu; F Arnaud; Douglas K Tadaki; Linda C Burkly; David M Harlan; Allan D Kirk
Human platelets activate porcine endothelial cells through a CD154-dependent pathway.
Transplantation 2001;72(11):1858-61.
2001: Eric Elster; He Xu; Douglas K Tadaki; S Montgomery; Linda C Burkly; Justin D Berning; RE Baumgartner; Francis Cruzata; R Marx; David M Harlan; Allan D Kirk
Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.
Transplantation 2001;72(9):1473-8.
2001: Clifford S Cho; Linda C Burkly; John H Fechner; Allan D Kirk; Terry D Oberley; Yinchen Dong; Kevin G Brunner; David Peters; C N Tenhoor; K Nadeau; Gokhan Yagci; N Ishido; Jacqueline M Schultz; Masahiro Tsuchida; Majed M Hamawy; Stuart J Knechtle
Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.
Transplantation 2001;72(4):587-97.
2001: Susan L Kalled; Anne H Cutler; Linda C Burkly
Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatment.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1740-7.
2001: R. Damaris Molano; Thierry Berney; Hua Li; Pierre Cattan; Antonello Pileggi; Caterina Vizzardelli; Norma S Kenyon; Camillo Ricordi; Linda C Burkly; Luca Inverardi
Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation.
Diabetes 2001;50(2):270-6.
2001: Eric Elster; He Xu; Douglas K Tadaki; Linda C Burkly; Justin D Berning; RE Baumgartner; Francis Cruzata; Noelle B Patterson; David M Harlan; Allan D Kirk
Primate skin allotransplantation with anti-CD154 monotherapy.
Transplantation proceedings 2001;33(1-2):675-6.
2001: R. Damaris Molano; Thierry Berney; Antonello Pileggi; Camillo Ricordi; Linda C Burkly; David M Rothstein; Giacomo P Basadonna; Luca Inverardi
Prolonged survival of allogeneic islet grafts in NOD mice treated with a combination of anti-CD45RB and anti-CD154 antibodies.
Transplantation proceedings 2001;33(1-2):248-9.
2001: He Xu; Eric Elster; D Scott Batty; Justin D Berning; Linda C Burkly; Robert L Kampen; S Swanson; Douglas K Tadaki; David M Harlan; Allan D Kirk
Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model.
Transplantation proceedings 2001;33(1-2):223-4.
2000: J Qian; Linda C Burkly; EP Smith; Janine L Ferrant; Leon Hoyer; David W Scott; Christian Haudenschild
Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titer.
European journal of immunology 2000;30(9):2548-54.
2000: Douglas K Tadaki; Nancy Craighead; Abha A Saini; Abbie Celniker; Linda C Burkly; Kelvin P Lee; John P Chute; David M Harlan; Allan D Kirk
Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity.
Transplantation 2000;70(1):162-7.
2000: Esther Lutgens; Kitty B J M Cleutjens; Sylvia Heeneman; Victor E Koteliansky; Linda C Burkly; Mat J A P Daemen
Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7464-9.
2000: L C Wang; Z Y Liu; Laure Gambardella; A Delacour; R Shapiro; J Yang; Irene Sizing; Paul Rayhorn; Ellen A Garber; Christopher D Benjamin; Kevin P Williams; Frederick R Taylor; Yann Barrandon; L Ling; Linda C Burkly
Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration.
The Journal of investigative dermatology 2000;114(5):901-8.
1999: Norma S Kenyon; MA Chatzipetrou; M Masetti; A Ranuncoli; M Oliveira; JL Wagner; Allan D Kirk; D M Harlan; Linda C Burkly; Camillo Ricordi
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8132-7.
1999: Norma S Kenyon; LA Fernandez; R Lehmann; M Masetti; A Ranuncoli; MA Chatzipetrou; giuseppe iaria; Dongmei Han; JL Wagner; Phillip Ruiz; Mariana Berho; Luca Inverardi; Rodolfo Alejandro; Daniel Mintz; Allan D Kirk; D M Harlan; Linda C Burkly; Camillo Ricordi
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
Diabetes 1999;48(7):1473-81.
1999: Allan D Kirk; Linda C Burkly; D Scott Batty; RE Baumgartner; Justin D Berning; K Buchanan; John H Fechner; RL Germond; Robert L Kampen; Noelle B Patterson; S John Swanson; Douglas K Tadaki; C N TenHoor; L White; Stuart J Knechtle; David M Harlan
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.
Nature medicine 1999;5(6):686-93.
1998: Adrian Whitty; N Raskin; Dian L Olson; C W Borysenko; Christine Ambrose; Christopher D Benjamin; Linda C Burkly
Interaction affinity between cytokine receptor components on the cell surface.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13165-70.
1998: Darren P Baker; Adrian Whitty; Mohammad Zafari; Dian L Olson; Cathy Hession; Konrad Miatkowski; L S Avedissian; Susan F Foley; M L McKay; Christopher D Benjamin; Linda C Burkly
The murine anti-human common gamma chain monoclonal antibody CP.B8 blocks the second step in the formation of the intermediate affinity IL-2 receptor.
Biochemistry 1998;37(41):14337-49.
1998: N Raskin; Aniela Jakubowski; Irene Sizing; Dian L Olson; Susan L Kalled; Cathy Hession; Christopher D Benjamin; Darren P Baker; Linda C Burkly
Molecular mapping with functional antibodies localizes critical sites on the human IL receptor common gamma (gamma c) chain.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3474-83.
1997: G Chi-Rosso; Philip J Gotwals; J Yang; L Ling; K Jiang; B Chao; Darren P Baker; Linda C Burkly; S E Fawell; Victor E Koteliansky
Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins.
The Journal of biological chemistry 1997;272(50):31447-52.
1997: C Pujades; Ronen Alon; RL Yauch; A Masumoto; Linda C Burkly; C Chen; T A Springer; Roy R Lobb; Martin Helmer
Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.
Molecular biology of the cell 1997;8(12):2647-57.
1997: Keith A Reimann; W Lin; Sarah A Bixler; Beth Browning; BN Ehrenfels; J Lucci; Konrad Miatkowski; Dian Olson; T H Parish; M D Rosa; F B Oleson; Yen-Ming Hsu; E A Padlan; Norman L Letvin; Linda C Burkly
A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties.
AIDS research and human retroviruses 1997;13(11):933-43.
1996: Roy R Lobb; William W Abraham; Linda C Burkly; A Gill; W Ma; J A Knight; Diane Leone; G Antognetti; R Blake Pepinsky
Pathophysiologic role of alpha 4 integrins in the lung.
Annals of the New York Academy of Sciences 1996;796():113-23.
1995: Roy R Lobb; G Antognetti; R Blake Pepinsky; Linda C Burkly; Diane Leone; Adrian Whitty
A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins.
Cell adhesion and communication 1995;3(5):385-97.
1995: A Jakubowski; B N Ehrenfels; R Blake Pepinsky; Linda C Burkly
Vascular cell adhesion molecule-Ig fusion protein selectively targets activated alpha 4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):938-46.
1995: A Jakubowski; M D Rosa; Sarah A Bixler; Roy R Lobb; Linda C Burkly
Vascular cell adhesion molecule (VCAM)-Ig fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor.
Cell adhesion and communication 1995;3(2):131-42.
1995: Keith A Reimann; Richard L Cate; Y Wu; L Palmer; D Olson; B C Waite; Norman L Letvin; Linda C Burkly
In vivo administration of CD4-specific monoclonal antibody: effect on provirus load in rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques.
AIDS research and human retroviruses 1995;11(4):517-25.
1995: Linda C Burkly; Cathy Hession; L Ogata; C Reilly; L A Marconi; D Olson; R Tizard; Richard L Cate; David Lo
Expression of relB is required for the development of thymic medulla and dendritic cells.
Nature 1995;373(6514):531-6.
1994: Linda C Burkly; A Jakubowski; M Hattori
Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin.
Diabetes 1994;43(4):529-34.
1993: Linda C Burkly; S Degermann; J Longley; James Hagman; R L Brinster; David Lo; R A Flavell
Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):3954-60.
1993: J P Moore; Linda C Burkly; Ruth I Connor; Y Cao; R Tizard; David D Ho; R A Fisher
Adaptation of two primary human immunodeficiency virus type 1 isolates to growth in transformed T cell lines correlates with alterations in the responses of their envelope glycoproteins to soluble CD4.
AIDS research and human retroviruses 1993;9(6):529-39.
1993: Keith A Reimann; Linda C Burkly; B Burrus; B C Waite; Carol I Lord; Norman L Letvin
In vivo administration to rhesus monkeys of a CD4-specific monoclonal antibody capable of blocking AIDS virus replication.
AIDS research and human retroviruses 1993;9(3):199-207.
1992: B Pepinsky; Cathy Hession; L L Chen; P Moy; Linda C Burkly; A Jakubowski; E P Chow; C Benjamin; G Chi-Rosso; S Luhowskyj
Structure/function studies on vascular cell adhesion molecule-1.
The Journal of biological chemistry 1992;267(25):17820-6.
1992: Linda C Burkly; D Olson; R Shapiro; G Winkler; J J Rosa; D W Thomas; C Williams; P Chisholm
Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1779-87.
1992: T Hasunuma; H Tsubota; M Watanabe; Zheng W Chen; Carol I Lord; Linda C Burkly; J F Daley; Norman L Letvin
Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1841-6.
1991: Linda C Burkly; A Jakubowski; B M Newman; M D Rosa; G Chi-Rosso; Roy R Lobb
Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation.
European journal of immunology 1991;21(11):2871-5.
1989: Linda C Burkly; David Lo; O Kanagawa; R L Brinster; R A Flavell
T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E.
Nature 1989;342(6249):564-6.