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Simon MacKenzie

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Simon MacKenzie; S F Hastings; C Wells
Cyclic nucleotide phosphodiesterase assay technology.
Mark W Irvine; Graham L Patrick; Justin Kewney; Stuart F Hastings; Simon MacKenzie
Rhodanine derivatives as novel inhibitors of PDE4.
David R Adams; Achamma Abraham; Jun Asano; Catherine Breslin; Dick Colin; Ulrich Ixkes; Blair Johnston; Derek Johnston; Justin Kewnay; Simon P Mackay; Simon MacKenzie; Morag McFarlane; Lee Mitchell; Daniel Spinks; Yasuo Takano
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.

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All Publications

2010: Simon MacKenzie; S F Hastings; C Wells
Cyclic nucleotide phosphodiesterase assay technology.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2010;Chapter 3():Unit 3.12.
2008: Mark W Irvine; Graham L Patrick; Justin Kewney; Stuart F Hastings; Simon MacKenzie
Rhodanine derivatives as novel inhibitors of PDE4.
Bioorganic & medicinal chemistry letters 2008;18(6):2032-7.
2007: David R Adams; Achamma Abraham; Jun Asano; Catherine Breslin; Dick Colin; Ulrich Ixkes; Blair Johnston; Derek Johnston; Justin Kewnay; Simon P Mackay; Simon MacKenzie; Morag McFarlane; Lee Mitchell; Daniel Spinks; Yasuo Takano
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6579-83.
2007: David M Brown; L Hutchison; Ken Donaldson; Simon MacKenzie; Dick Colin; Vicki Stone
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.
Toxicology letters 2007;168(1):1-6.
2006: Lucien C D Gibson; Stuart F Hastings; Ian McPhee; Robert A Clayton; Clare E Darroch; Alison Mackenzie; Fiona L Mackenzie; Michiaki Nagasawa; Patricia A Stevens; Simon MacKenzie
The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.
European journal of pharmacology 2006;538(1-3):39-42.
2005: Ian McPhee; Lucien C D Gibson; J Kewney; Clare E Darroch; P A Stevens; Daniel Spinks; A Cooreman; Simon MacKenzie
Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease.
Biochemical Society transactions 2005;33(Pt 6):1330-2.
2004: Eric Livingston; Clare E Darroch; Rekha Chaudhuri; Ian McPhee; Alex D McMahon; Simon MacKenzie; Neil C Thomson
Glucocorticoid receptor alpha:beta ratio in blood mononuclear cells is reduced in cigarette smokers.
The Journal of allergy and clinical immunology 2004;114(6):1475-8.
2004: Robert A Clayton; Dick Colin; Alison Mackenzie; Michiaki Nagasawa; Deirdre Galbraith; Stuart F Hastings; Simon MacKenzie
The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma.
Respiratory research 2004;5():4.
2002: Simon MacKenzie; George S Baillie; Ian McPhee; Carolynn MacKenzie; Rachael Seamons; Theresa McSorley; Jennifer Millen; Matthew B Beard; Gino van Heeke; Miles D Houslay
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
British journal of pharmacology 2002;136(3):421-33.
2001: George S Baillie; Simon MacKenzie; Miles D Houslay
Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).
Molecular pharmacology 2001;60(5):1100-11.
2000: George S Baillie; Simon MacKenzie; Ian McPhee; Miles D Houslay
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.
British journal of pharmacology 2000;131(4):811-9.
2000: Simon MacKenzie; George S Baillie; Ian McPhee; Graeme B Bolger; Miles D Houslay
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.
The Journal of biological chemistry 2000;275(22):16609-17.
2000: Simon MacKenzie; Miles D Houslay
Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells.
The Biochemical journal 2000;347(Pt 2):571-8.
1999: R Hoffmann; George S Baillie; Simon MacKenzie; Stephen J Yarwood; Miles D Houslay
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.
The EMBO journal 1999;18(4):893-903.
1998: I Fleming; Simon MacKenzie; Richard G Vernon; NG Anderson; Miles D Houslay; E Kilgour
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
The Biochemical journal 1998;333 ( Pt 3)():719-27.
1998: Simon MacKenzie; Stephen J Yarwood; Alexander H Peden; Graeme B Bolger; Richard G Vernon; Miles D Houslay
Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3549-54.
1998: Grant Scotland; Matthew B Beard; Suat Erdogan; Elaine Huston; F McCallum; Simon MacKenzie; Alexander H Peden; L Pooley; N G Rena; AH Ross; Stephen J Yarwood; Miles D Houslay
Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.
Methods (San Diego, Calif.) 1998;14(1):65-79.
1997: I M Fleming; Simon MacKenzie; Miles D Houslay; Richard G Vernon; E Kilgour
Antisense technology reveals distinct roles for protein kinase C isoforms during 3T3-F442A preadipocyte differentiation.
Biochemical Society transactions 1997;25(4):S665.
1997: Simon MacKenzie; I Fleming; Miles D Houslay; NG Anderson; E Kilgour
Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells.
The Biochemical journal 1997;324 ( Pt 1)():159-65.
1997: I M Fleming; Simon MacKenzie; Miles D Houslay; E Kilgour
Protein kinase C isoform expression during differentiation of 3T3-F442A preadipocytes.
Biochemical Society transactions 1997;25(2):211S.
1997: Miles D Houslay; Grant Scotland; Suat Erdogan; Elaine Huston; Simon MacKenzie; J F McCallum; Ian McPhee; L Pooley; G Rena; A Ross; Matthew B Beard; A Peder; F Begg; I Wilkinson; Stephen J Yarwood; C Ackerman; Emma S Houslay; R Hoffman; P Engels; Michael Sullivan; Graeme B Bolger
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Biochemical Society transactions 1997;25(2):374-81.
1995: Simon MacKenzie; Michael Kerr
IgM monoclonal antibodies recognizing Fc alpha R but not Fc gamma RIII trigger a respiratory burst in neutrophils although both trigger an increase in intracellular calcium levels and degranulation.
The Biochemical journal 1995;306 ( Pt 2)():519-23.
1995: Michael Kerr; W W Stewart; B C Bonner; M R Greer; Simon MacKenzie; M G Steele
The diversity of leucocyte IgA receptors.
Contributions to nephrology 1995;111():60-4; discussion 65.