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Haruhiko Akiyama

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Procedures

Immunohistochemistry

Anatomy

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Chemicals & Drugs

Physiology

Brain Chemistry

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Co-Publications
Name
68
Ikeda, K
58
McGeer, Patrick
23
Iseki, Eizo
22
Kosaka, Kenji
21
McGeer, Edith
18
Haga, Chie
16
Tsuchiya, Kuniaki
14
Arai, Tetsuaki
13
Tsuchiya, Kuniaki
11
Niizato, Kazuhiro
10
Mori, Hiroshi
10
Iritani, Shuji
9
Togo, Takashi
9
Yokota, Osamu
8
Uchikado, Hirotake

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Publications

TOP 3
Nalam Roopa L; Andreu-Vieyra Claudia; Braun Robert E; Akiyama Haruhiko; Matzuk Martin M
Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells.
Kobayashi Zen; Tsuchiya Kuniaki; Uchihara Toshiki; Nakamura Ayako; Haga Chie; Yokota Osamu; Ishizu Hideki; Taki Kazuhiro; Arai Tetsuaki; Akiyama Haruhiko; Mizusawa Hidehiro
Intractable hiccup caused by medulla oblongata lesions: a study of an autopsy patient with possible neuromyelitis optica.
Sugata Hisato; Matsuo Kazuhiko; Nakagawa Taisuke; Takahashi Mikiko; Mukai Hideyuki; Ono Yoshitaka; Maeda Kiyoshi; Akiyama Haruhiko; Kawamata Toshio
A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.

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All Publications

2009: Nalam Roopa L; Andreu-Vieyra Claudia; Braun Robert E; Akiyama Haruhiko; Matzuk Martin M
Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(11):1900-13.
2009: Kobayashi Zen; Tsuchiya Kuniaki; Uchihara Toshiki; Nakamura Ayako; Haga Chie; Yokota Osamu; Ishizu Hideki; Taki Kazuhiro; Arai Tetsuaki; Akiyama Haruhiko; Mizusawa Hidehiro
Intractable hiccup caused by medulla oblongata lesions: a study of an autopsy patient with possible neuromyelitis optica.
Journal of the neurological sciences 2009;285(1-2):241-5.
2009: Sugata Hisato; Matsuo Kazuhiko; Nakagawa Taisuke; Takahashi Mikiko; Mukai Hideyuki; Ono Yoshitaka; Maeda Kiyoshi; Akiyama Haruhiko; Kawamata Toshio
A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.
Neuroscience letters 2009;459(2):96-9.
2009: Schwab Claudia; Arai Tetsuaki; Hasegawa Masato; Akiyama Haruhiko; Yu Sheng; McGeer Patrick L
TDP-43 pathology in familial British dementia.
Acta neuropathologica 2009;118(2):303-11.
2009: Yamashita Makiko; Nonaka Takashi; Arai Tetsuaki; Kametani Fuyuki; Buchman Vladimir L; Ninkina Natalia; Bachurin Sergey O; Akiyama Haruhiko; Goedert Michel; Hasegawa Masato
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters 2009;583(14):2419-24.
2009: Kametani Fuyuki; Nonaka Takashi; Suzuki Takehiro; Arai Tetsuaki; Dohmae Naoshi; Akiyama Haruhiko; Hasegawa Masato
Identification of casein kinase-1 phosphorylation sites on TDP-43.
Biochemical and biophysical research communications 2009;382(2):405-9.
2009: Yokota Osamu; Tsuchiya Kuniaki; Arai Tetsuaki; Yagishita Saburo; Matsubara Osamu; Mochizuki Akihide; Tamaoka Akira; Kawamura Mitsuru; Yoshida Hidetoshi; Terada Seishi; Ishizu Hideki; Kuroda Shigetoshi; Akiyama Haruhiko
Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions.
Acta neuropathologica 2009;117(4):429-44.
2009: Arai Tetsuaki; Mackenzie Ian R A; Hasegawa Masato; Nonoka Takashi; Niizato Kazhuhiro; Tsuchiya Kuniaki; Iritani Shuji; Onaya Mitsumoto; Akiyama Haruhiko
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica 2009;117(2):125-36.
2009: Kobayashi Zen; Tsuchiya Kuniaki; Machida Akira; Goto Jun; Yokota Osamu; Miake Hirotomo; Watabiki Sadakiyo; Taki Kazuhiro; Ishizu Hideki; Haga Chie; Arai Tetsuaki; Akiyama Haruhiko; Mizusawa Hidehiro
Metastatic CNS lymphoma presenting with periventricular dissemination - MRI and neuropathological findings in an autopsy case.
Journal of the neurological sciences 2009;277(1-2):109-13.
2009: Fujishiro Hiroshige; Uchikado Hirotake; Arai Tetsuaki; Hasegawa Masato; Akiyama Haruhiko; Yokota Osamu; Tsuchiya Kuniaki; Togo Takashi; Iseki Eizo; Hirayasu Yoshio
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease.
Acta neuropathologica 2009;117(2):151-8.
2009: Nonaka Takashi; Arai Tetsuaki; Buratti Emanuele; Baralle Francisco E; Akiyama Haruhiko; Hasegawa Masato
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.
FEBS letters 2009;583(2):394-400.
2009: Mackenzie Ian R A; Neumann Manuela; Bigio Eileen H; Cairns Nigel J; Alafuzoff Irina; Kril Jillian; Kovacs Gabor G; Ghetti Bernardino; Halliday Glenda; Holm Ida E; Ince Paul G; Kamphorst Wouter; Revesz Tamas; Rozemuller Annemieke J M; Kumar-Singh Samir; Akiyama Haruhiko; Baborie Atik; Spina Salvatore; Dickson Dennis W; Trojanowski John Q; Mann David M A
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations.
Acta neuropathologica 2009;117(1):15-8.
2008: Hasegawa Masato; Arai Tetsuaki; Nonaka Takashi; Kametani Fuyuki; Yoshida Mari; Hashizume Yoshio; Beach Thomas G; Morita Mitsuya; Nakano Imaharu; Oda Tatsuro; Tsuchiya Kuniaki; Akiyama Haruhiko
[Significance of the TDP-43 deposition in FTLD-U and ALS]
Rinsho shinkeigaku = Clinical neurology 2008;48(11):994-7.
2008: Arai Tetsuaki; Hasegawa Masato; Nishihara Masugi; Nonaka Takashi; Kametani Fuyuki; Yoshida Mari; Hashizume Yoshio; Beach Thomas G; Morita Mitsuya; Nakano Imaharu; Oda Tatsuro; Tsuchiya Kuniaki; Akiyama Haruhiko
[Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]
Rinsho shinkeigaku = Clinical neurology 2008;48(11):990-3.
2008: Inukai Yuki; Nonaka Takashi; Arai Tetsuaki; Yoshida Mari; Hashizume Yoshio; Beach Thomas G; Buratti Emanuele; Baralle Francisco E; Akiyama Haruhiko; Hisanaga Shin-ichi; Hasegawa Masato
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.
FEBS letters 2008;582(19):2899-904.
2008: Hasegawa Masato; Arai Tetsuaki; Nonaka Takashi; Kametani Fuyuki; Yoshida Mari; Hashizume Yoshio; Beach Thomas G; Buratti Emanuele; Baralle Francisco; Morita Mitsuya; Nakano Imaharu; Oda Tatsuro; Tsuchiya Kuniaki; Akiyama Haruhiko
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Annals of neurology 2008;64(1):60-70.
2008: Yokota Osamu; Tsuchiya Kuniaki; Hayashi Masaharu; Kakita Akiyoshi; Ohwada Kiyoshi; Ishizu Hideki; Takahashi Hitoshi; Akiyama Haruhiko
Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 1.
Acta neuropathologica 2008;116(1):57-66.
2008: Yokota Osamu; Tsuchiya Kuniaki; Terada Seishi; Ishizu Hideki; Uchikado Hirotake; Ikeda Manabu; Oyanagi Kiyomitsu; Nakano Imaharu; Murayama Shigeo; Kuroda Shigetoshi; Akiyama Haruhiko
Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study.
Acta neuropathologica 2008;115(5):561-75.
2008: Obi Kimiko; Akiyama Haruhiko; Kondo Hiromi; Shimomura Yoko; Hasegawa Masato; Iwatsubo Takeshi; Mizuno Yoshikuni; Mochizuki Hideki
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
Experimental neurology 2008;210(2):409-20.
2008: Sakai Tsutomu; Oshima Akihiko; Nozaki Yusuke; Ida Itsuro; Haga Chie; Akiyama Haruhiko; Nakazato Yoichi; Mikuni Masahiko
Changes in density of calcium-binding-protein-immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder.
Neuropathology : official journal of the Japanese Society of Neuropathology 2008;28(2):143-50.
2008: Ota Satoru; Tsuchiya Kuniaki; Anno Midori; Niizato Kazuhiro; Akiyama Haruhiko
Distribution of cerebello-olivary degeneration in idiopathic late cortical cerebellar atrophy: clinicopathological study of four autopsy cases.
Neuropathology : official journal of the Japanese Society of Neuropathology 2008;28(1):43-50.
2007: Yokota Osamu; Tsuchiya Kuniaki; Noguchi Yoshimasa; Akabane Hisamasa; Ishizu Hideki; Saito Yukinobu; Akiyama Haruhiko
Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(6):539-50.
2007: Tomomura M; Morita N; Yoshikawa F; Konishi A; Akiyama H; Furuichi T; Kamiguchi H
Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family.
Neuroscience 2007;148(2):510-21.
2007: Obi Kimiko; Tsuchiya Kuniaki; Anno Midori; Ohta Satoshi; Nakamura Ryosuke; Akiyama Haruhiko
[Autopsy case of meningovascular neurosyphilis associated with Fischer's plaques]
Brain and nerve = Shinkei kenkyu no shinpo 2007;59(7):797-803.
2007: Hasegawa Masato; Arai Tetsuaki; Akiyama Haruhiko; Nonaka Takashi; Mori Hiroshi; Hashimoto Tomoyo; Yamazaki Mineo; Oyanagi Kiyomitsu
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.
Brain : a journal of neurology 2007;130(Pt 5):1386-94.
2007: Yokota Osamu; Tsuchiya Kuniaki; Terada Seishi; Oshima Kenichi; Ishizu Hideki; Matsushita Masaaki; Kuroda Shigetoshi; Akiyama Haruhiko
Alcoholic cerebellar degeneration: a clinicopathological study of six Japanese autopsy cases and proposed potential progression pattern in the cerebellar lesion.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(2):99-113.
2007: Oda Tatsuro; Tsuchiya Kuniaki; Arai Tetsuaki; Togo Takashi; Uchikado Hirotake; de Silva Rohan; Lees Andrew; Akiyama Haruhiko; Haga Chie; Ikeda Kenji; Kato Motoichiro; Kato Yuji; Hara Tsunekatsu; Onaya Mitsumoto; Hori Koji; Teramoto Hiroshi; Tominaga Itaru
Pick's disease with Pick bodies: an unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(1):81-9.
2007: Yokota Osamu; Tsuchiya Kuniaki; Uchihara Toshiki; Ujike Hiroshi; Terada Seishi; Takahashi Mafuyu; Kimura Yuji; Ishizu Hideki; Akiyama Haruhiko; Kuroda Shigetoshi
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(1):21-35.
2007: Nakatani Noriaki; Ohnishi Tetsuo; Iwamoto Kazuya; Watanabe Akiko; Iwayama Yoshimi; Yamashita Shunji; Ishitsuka Yuichi; Moriyama Kenji; Nakajima Mizuho; Tatebayashi Yoshitaka; Akiyama Haruhiko; Higuchi Teruhiko; Kato Tadafumi; Yoshikawa Takeo
Expression analysis of actin-related genes as an underlying mechanism for mood disorders.
Biochemical and biophysical research communications 2007;352(3):780-6.
2006: Takao Masaki; Tsuchiya Kuniaki; Mimura Masaru; Momoshima Suketaka; Kondo Hiromi; Akiyama Haruhiko; Suzuki Norihiro; Mihara Ban; Takagi Yasuyuki; Koto Atsuo
Corticobasal degeneration as cause of progressive non-fluent aphasia: clinical, radiological and pathological study of an autopsy case.
Neuropathology : official journal of the Japanese Society of Neuropathology 2006;26(6):569-78.
2006: Arai Tetsuaki; Hasegawa Masato; Akiyama Haruhiko; Ikeda Kenji; Nonaka Takashi; Mori Hiroshi; Mann David; Tsuchiya Kuniaki; Yoshida Mari; Hashizume Yoshio; Oda Tatsuro
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Biochemical and biophysical research communications 2006;351(3):602-11.
2006: Sakurai Yasuhisa; Tsuchiya Kuniaki; Oda Tatsuro; Hori Koji; Tominaga Itaru; Akiyama Haruhiko; Bando Mitsuaki; Haga Chie; Iwata Makoto; Mannen Toru
Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient.
Journal of the neurological sciences 2006;250(1-2):3-9.
2006: Yokota Osamu; Tsuchiya Kuniaki; Itoh Yoshinori; Ishizu Hideki; Akiyama Haruhiko; Ikeda Manabu; Kuzuhara Shigeki; Otomo Eiichi
Frontotemporal lobar degeneration with ubiquitin pathology: an autopsy case presenting with semantic dementia and upper motor neuron signs with a clinical course of 19 years.
Acta neuropathologica 2006;112(6):739-49.
2006: Yokota Osamu; Tsuchiya Kuniaki; Oda Tatsurou; Ishihara Takeshi; de Silva Rohan; Lees Andrew J; Arai Tetsuaki; Uchihara Toshiki; Ishizu Hideki; Kuroda Shigetoshi; Akiyama Haruhiko
Amyotrophic lateral sclerosis with dementia: an autopsy case showing many Bunina bodies, tau-positive neuronal and astrocytic plaque-like pathologies, and pallido-nigral degeneration.
Acta neuropathologica 2006;112(5):633-45.
2006: Murayama Kiyoko S; Kametani Fuyuki; Saito Shinya; Kume Hideaki; Akiyama Haruhiko; Araki Wataru
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
The European journal of neuroscience 2006;24(5):1237-44.
2006: Iseki Eizo; Yamamoto Ryoko; Murayama Norio; Minegishi Michiko; Togo Takashi; Katsuse Omi; Kosaka Kenji; Akiyama Haruhiko; Tsuchiya Kuniaki; de Silva Rohan; Andrew Lees; Arai Heii
Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia.
Neuroscience letters 2006;405(1-2):29-33.
2006: Yokota Osamu; Tsuchiya Kuniaki; Terada Seishi; Oshima Kenichi; Ishizu Hideki; Matsushita Masaaki; Kuroda Shigetoshi; Akiyama Haruhiko
Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems.
Acta neuropathologica 2006;112(1):43-51.
2006: Tsuchiya Kuniaki; Piao Yue-Shan; Oda Tatsuro; Mochizuki Akihide; Arima Kunimasa; Hasegawa Kazuko; Haga Chie; Kakita Akiyoshi; Hori Koji; Tominaga Itaru; Yagishita Saburo; Akiyama Haruhiko; Takahashi Hitoshi
Pathological heterogeneity of the precentral gyrus in Pick's disease: a study of 16 autopsy cases.
Acta neuropathologica 2006;112(1):29-42.
2006: Oshima Kenichi; Akiyama Haruhiko; Tsuchiya Kuniaki; Kondo Hiromi; Haga Chie; Shimomura Yoko; Iseki Eizo; Uchikado Hirotake; Kato Masanori; Niizato Kazuhiro; Arai Heii
Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology.
Acta neuropathologica 2006;111(6):510-8.
2006: Niizato Kazuhiro; Tsuchiya Kuniaki; Oshima Kenichi; Togi Mizuho; Nakamura Ryosuke; Ueno Hideki; Ito Kei; Akiyama Haruhiko
[An autopsied case of schizophrenic patient who died from heat stroke]
No to shinkei = Brain and nerve 2006;58(5):418-24.
2006: Akiyama Haruhiko
[Abeta, tau and alpha-synuclein and glial cells]
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2006;26(1):23-31.
2005: Ota Satoru; Tsuchiya Kuniaki; Akiyama Haruhiko
"Forme fruste" of amyotrophic lateral sclerosis with dementia: a report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(4):326-35.
2005: Oshima Kenichi; Tsuchiya Kuniaki; Miyazaki Hiroshi; Iritani Shuji; Niizato Kazuhiro; Nakamura Ryosuke; Ueno Hideki; Tohgi Mizuho; Akiyama Haruhiko; Arai Heii
[Autopsy case of Lewy body dementia associated with abundant argyrophilic grains]
No to shinkei = Brain and nerve 2005;57(8):695-700.
2005: Uchihara Toshiki; Tsuchiya Kuniaki; Nakamura Ayako; Akiyama Haruhiko
Argyrophilic grains are not always argyrophilic--distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods.
Acta neuropathologica 2005;110(2):158-64.
2005: Tsuchiya Kuniaki; Nakayama Hiroshi; Haga Chie; Oshima Kenichi; Niizato Kazuhiro; Arai Tetsuaki; Matsushita Masaaki; Akiyama Haruhiko
Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement.
Acta neuropathologica 2005;110(1):57-68.
2005: Tsuchiya Kuniaki; Oda Tatsuro; Yoshida Mari; Sasaki Hidenao; Haga Chie; Okino Hidemaro; Tominaga Itaru; Matsui Kenichi; Akiyama Haruhiko; Hashizume Yoshio
Degeneration of the inferior olive in spinocerebellar ataxia 6 may depend on disease duration: report of two autopsy cases and statistical analysis of autopsy cases reported to date.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(2):125-35.
2005: Uchihara Toshiki; Tsuchiya Kuniaki; Nakamura Ayako; Akiyama Haruhiko
Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods.
Acta neuropathologica 2005;109(5):483-9.
2005: Tsuchiya Kuniaki; Murayama Shigeo; Mitani Kazuko; Oda Tatsuro; Arima Kunimasa; Mimura Masaru; Nagura Hiroshi; Haga Chie; Akiyama Haruhiko; Yamanouchi Hiroshi; Mizusawa Hidehiro
Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases.
Acta neuropathologica 2005;109(4):353-66.
2005: Ota Satoru; Tsuchiya Kuniaki; Anno Midori; Akiyama Haruhiko
[An autopsy case of dementia lacking distinctive histology showing semantic dementia]
No to shinkei = Brain and nerve 2005;57(3):233-8.
2004: Kurokawa S; Shibaike H; Akiyama H; Yoshimura Y
Molecular and morphological differentiation between the crop and weedy types in velvetleaf (Abutilon theophrasti Medik.) using a chloroplast DNA marker: seed source of the present invasive velvetleaf in Japan.
Heredity 2004;93(6):603-9.
2004: Takeda Kazuya; Araki Wataru; Akiyama Haruhiko; Tabira Takeshi
Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1755-7.
2004: Uchikado Hirotake; Tsuchiya Kuniaki; Tominaga Itaru; Togo Takashi; Oshima Kenichi; Akiyama Haruhiko; Ikeda Kenji; Oda Tatsuro; Hirayasu Yoshio
[Argyrophilic grain disease clinically mimicking Parkinson's disease with dementia: report of an autopsy case]
No to shinkei = Brain and nerve 2004;56(9):785-8.
2004: Tsuchiya Kuniaki; Sano Michio; Shiotsu Hidetoshi; Akiyama Haruhiko; Watabiki Sadakiyo; Taki Kazuhiro; Kondo Hiromi; Nakano Imaharu; Ikeda Kenji
Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists: additional autopsy case with a clinical course of 19 years.
Neuropathology : official journal of the Japanese Society of Neuropathology 2004;24(3):228-35.
2004: Oshima Kenichi; Tsuchiya Kuniaki; Iritani Shuji; Niizato Kazuhiro; Akiyama Haruhiko; Ikeda Kenji; Arai Heii
[An autopsy case of senile dementia with pathological features of Parkinson's disease]
No to shinkei = Brain and nerve 2004;56(7):603-6.
2004: Togo Takashi; Akiyama Haruhiko; Iseki Eizo; Uchikado Hirotake; Kondo Hiromi; Ikeda Kenji; Tsuchiya Kuniaki; de Silva Rohan; Lees Andrew; Kosaka Kenji
Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions.
Acta neuropathologica 2004;107(6):504-8.
2004: Uchikado Hirotake; Akiyama Haruhiko; Kondo Hiromi; Ikeda Kenji; Tsuchiya Kuniaki; Kato Masanori; Oda Tatsuro; Togo Takashi; Iseki Eizo; Kosaka Kenji
Activation of vascular endothelial cells and perivascular cells by systemic inflammation-an immunohistochemical study of postmortem human brain tissues.
Acta neuropathologica 2004;107(4):341-51.
2004: Oshima Kenichi; Tsuchiya Kuniaki; Iritani Shuji; Niizato Kazuhiro; Akiyama Haruhiko; Arai Heii; Ikeda Kenji
[An autopsy case of "progressive supranuclear palsy" without psychiatric or neurological signs]
No to shinkei = Brain and nerve 2004;56(2):157-61.
2004: Akiyama Haruhiko; McGeer Patrick L
Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease.
Nature medicine 2004;10(2):117-8; author reply 118-9.
2004: Arai Tetsuaki; Ikeda Kenji; Akiyama Haruhiko; Nonaka Takashi; Hasegawa Masato; Ishiguro Koichi; Iritani Shuji; Tsuchiya Kuniaki; Iseki Eizo; Yagishita Saburo; Oda Tatsuro; Mochizuki Akihide
Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration.
Annals of neurology 2004;55(1):72-9.
2004: Akiyama Haruhiko; Kondo Hiromi; Arai Tetsuaki; Ikeda Kenji; Kato Masanori; Iseki Eizo; Schwab Claudia; McGeer Patrick L
Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain.
Acta neuropathologica 2004;107(1):53-8.
2003: Oshima K; Tsuchiya K; Arai T; Akiyama H; Iritani S; Niizato K; Matsushita M; Ikeda K
Atypical late-onset dementia characterized by limbic degeneration with coiled bodies and argyrophilic threads.
Clinical neuropathology 2003;22(6):296-303.
2003: Katsuse Omi; Iseki Eizo; Arai Tetsuaki; Akiyama Haruhiko; Togo Takashi; Uchikado Hirotake; Kato Masanori; de Silva Rohan; Lees Andrew; Kosaka Kenji
4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy.
Acta neuropathologica 2003;106(3):251-60.
2003: Arai Tetsuaki; Nonaka Takashi; Hasegawa Masato; Akiyama Haruhiko; Yoshida Mari; Hashizume Yosio; Tsuchiya Kuniaki; Oda Tatsuro; Ikeda Kenji
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62.
Neuroscience letters 2003;342(1-2):41-4.
2003: Arai Tetsuaki; Ikeda Kenji; Akiyama Haruhiko; Tsuchiya Kuniaki; Iritani Shuji; Ishiguro Koichi; Yagishita Saburo; Oda Tatsuro; Odawara Toshinari; Iseki Eizo
Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Acta neuropathologica 2003;105(5):489-98.
2003: Oshima Kenichi; Tsuchiya Kuniaki; Iritani Shuji; Ueno Hideki; Niizato Kazuhiro; Nakamura Ryosuke; Arai Tetsuaki; Akiyama Haruhiko; Ikeda Kenji
[An autopsy case of argyrophilic grain dementia with abundant neurofibrillary tangles]
No to shinkei = Brain and nerve 2003;55(2):133-8.
2002: Tsuchiya Kuniaki; Takahashi Matuu; Shiotsu Hidetoshi; Akiyama Haruhiko; Haga Chie; Watabiki Sadakiyo; Taki Kazuhito; Nakano Imaharu; Ikeda Kenji
Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy: a report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology 2002;22(4):308-16.
2002: Ikeda Kenji; Akiyama Haruhiko; Arai Tetsuaki; Ueno Hideki; Tsuchiya Kuniaki; Kosaka Kenji
Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia.
Acta neuropathologica 2002;104(1):21-8.
2002: Togo Takashi; Akiyama Haruhiko; Iseki Eizo; Kondo Hiromi; Ikeda Kenji; Kato Masanori; Oda Tatsuro; Tsuchiya Kuniaki; Kosaka Kenji
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases.
Journal of neuroimmunology 2002;124(1-2):83-92.
2002: Ikeda Kenji; Akiyama Haruhiko; Arai Tetsuaki; Tsuchiya Kuniaki
Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease.
Acta neuropathologica 2002;103(2):115-8.
2001: Akiyama H; Katayama S; Tanaka K; Korosue K
[Multiple spinal arteriovenous fistulas occurring at conus medullaris and dura of the sacral region: a case report]
No shinkei geka. Neurological surgery 2001;29(12):1177-81.
2001: Akiyama H; Kondo H; Ikeda K; Kato M; McGeer P L
Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.
Brain research 2001;902(2):277-81.
2001: Arai T; Ikeda K; Akiyama H; Tsuchiya K; Yagishita S; Takamatsu J
Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy.
Neuroreport 2001;12(5):935-8.
2001: Uchihara T; Sato T; Suzuki H; Ikeda K; Akiyama H; Takatori T
Bunina body in frontal lobe dementia without clinical manifestations of motor neuron disease.
Acta neuropathologica 2001;101(3):281-4.
2001: Arai T; Ikeda K; Akiyama H; Shikamoto Y; Tsuchiya K; Yagishita S; Beach T; Rogers J; Schwab C; McGeer P L
Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy.
Acta neuropathologica 2001;101(2):167-73.
2001: Togo T; Iseki E; Marui W; Akiyama H; Uéda K; Kosaka K
Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies.
Journal of the neurological sciences 2001;184(1):71-5.
2001: Hino H; Akiyama H; Iseki E; Kato M; Kondo H; Ikeda K; Kosaka K
Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues.
Neuroscience letters 2001;297(2):105-8.
2001: Yasojima K; Akiyama H; McGeer E G; McGeer P L
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.
Neuroscience letters 2001;297(2):97-100.
2000: Togo T; Akiyama H; Kondo H; Ikeda K; Kato M; Iseki E; Kosaka K
Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases.
Brain research 2000;885(1):117-21.
2000: Ikeda K; Akiyama H; Arai T; Matsushita M; Tsuchiya K; Miyazaki H
Clinical aspects of argyrophilic grain disease.
Clinical neuropathology 2000;19(6):278-84.
2000: Akiyama H; Barger S; Barnum S; Bradt B; Bauer J; Cole G M; Cooper N R; Eikelenboom P; Emmerling M; Fiebich B L; Finch C E; Frautschy S; Griffin W S; Hampel H; Hull M; Landreth G; Lue L; Mrak R; Mackenzie I R; McGeer P L; O'Banion M K; Pachter J; Pasinetti G; Plata-Salaman C; Rogers J; Rydel R; Shen Y; Streit W; Strohmeyer R; Tooyoma I; Van Muiswinkel F L; Veerhuis R; Walker D; Webster S; Wegrzyniak B; Wenk G; Wyss-Coray T
Inflammation and Alzheimer's disease.
Neurobiology of aging 2000;21(3):383-421.
2000: Iseki E; Marui W; Akiyama H; Uéda K; Kosaka K
Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry.
Neuroscience letters 2000;286(1):69-73.
2000: Ikeda K; Akiyama H; Arai T; Kondo H; Haga C; Tsuchiya K; Yamada S; Murayama S; Hori A
Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain?
Neuroscience letters 2000;284(3):187-9.
2000: Akiyama H; Kondoh T; Kokunai T; Nagashima T; Saito N; Tamaki N
Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain.
Brain research 2000;858(1):172-6.
2000: Onoda A; Maruki Y; Matsuzaki M; Narabayasi Y; Sawada M; Iwasaki A; Enokida M; Kanaya M; Akiyama H; Yamauchi T
Abstinence from drink ameliorated cerebral blood flow and vasoreactivity in patients with chronic alcoholism.
The Keio journal of medicine 2000;49 Suppl 1():A107-8.
2000: Akiyama H; Arai T; Kondo H; Tanno E; Haga C; Ikeda K
Cell mediators of inflammation in the Alzheimer disease brain.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S47-53.
1999: Meyer J S; Rauch G M; Crawford K; Rauch R A; Konno S; Akiyama H; Terayama Y; Haque A
Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia.
International journal of geriatric psychiatry 1999;14(12):1050-61.
1999: Tomimoto H; Akiguchi I; Akiyama H; Ikeda K; Wakita H; Lin J X; Budka H
Vascular changes in white matter lesions of Alzheimer's disease.
Acta neuropathologica 1999;97(6):629-34.
1999: Arai T; Akiyama H; Ikeda K; Kondo H; Mori H
Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease.
Brain research 1999;823(1-2):202-6.
1999: Akiyama H; Mori H; Saido T; Kondo H; Ikeda K; McGeer P L
Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease.
Glia 1999;25(4):324-31.
1999: Arai T; Uéda K; Ikeda K; Akiyama H; Haga C; Kondo H; Kuroki N; Niizato K; Iritani S; Tsuchiya K
Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein.
Neuroscience letters 1999;259(2):83-6.
1999: Arai T; Ikeda K; Akiyama H; Haga C; Usami M; Sahara N; Iritani S; Mori H
A high incidence of apolipoprotein E epsilon4 allele in middle-aged non-demented subjects with cerebral amyloid beta protein deposits.
Acta neuropathologica 1999;97(1):82-4.
1999: Ikeda K; Akiyama H; Arai T; Oda T; Kato M; Iseki E; Kosaka K; Wakabayashi K; Takahashi H
Clinical aspects of 'senile dementia of the tangle type'-- a subset of dementia in the senium separable from late-onset Alzheimer's disease.
Dementia and geriatric cognitive disorders 1999;10(1):6-11.
1998: Ikeda K; Akiyama H; Arai T; Kondo H; Haga C; Iritani S; Tsuchiya K
Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains.
Neuroscience letters 1998;258(2):113-6.
1998: Iseki E; Marui W; Kosaka K; Akiyama H; Ueda K; Iwatsubo T
Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease.
Neuroscience letters 1998;258(2):81-4.
1998: Schwab C; Akiyama H; McGeer E G; McGeer P L
Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein.
Journal of neuropathology and experimental neurology 1998;57(12):1131-7.
1998: Matsusaka H; Ikeda K; Akiyama H; Arai T; Inoue M; Yagishita S
Astrocytic pathology in progressive supranuclear palsy: significance for neuropathological diagnosis.
Acta neuropathologica 1998;96(3):248-52.
1998: Iseki E; Li F; Odawara T; Hino H; Suzuki K; Kosaka K; Akiyama H; Ikeda K; Kato M
Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies.
Journal of the neurological sciences 1998;159(2):194-201.
1998: Chui D H; Shirotani K; Tanahashi H; Akiyama H; Ozawa K; Kunishita T; Takahashi K; Makifuchi T; Tabira T
Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease.
Journal of neuroscience research 1998;53(1):99-106.
1998: Meyer J S; Terayama Y; Konno S; Margishvili G M; Akiyama H; Rauch R A; Mortel K F; Wills P M
Age-related cerebrovascular disease alters the symptomatic course of migraine.
Cephalalgia : an international journal of headache 1998;18(4):202-8; discussion 171.
1998: Honda M; Akiyama H; Yamada Y; Kondo H; Kawabe Y; Takeya M; Takahashi K; Suzuki H; Doi T; Sakamoto A; Ookawara S; Mato M; Gough P J; Greaves D R; Gordon S; Kodama T; Matsushita M
Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease.
Biochemical and biophysical research communications 1998;245(3):734-40.
1998: Ikeda K; Akiyama H; Arai T; Nishimura T
Glial tau pathology in neurodegenerative diseases: their nature and comparison with neuronal tangles.
Neurobiology of aging 1998;19(1 Suppl):S85-91.
1998: Meyer J S; Terayama Y; Konno S; Akiyama H; Margishvili G M; Mortel K F
Risk factors for cerebral degenerative changes and dementia.
European neurology 1998;39 Suppl 1():7-16.
1997: Akiyama H; Mori H; Sahara N; Kondo H; Ikeda K; Nishimura T; Oda T; McGeer P L
Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for A beta 40 and the A beta that ends at residues alanine42/threonine43 (A beta 42).
Neurochemical research 1997;22(12):1499-506.
1997: Akiyama H; Meyer J S; Mortel K F; Terayama Y; Thornby J I; Konno S
Normal human aging: factors contributing to cerebral atrophy.
Journal of the neurological sciences 1997;152(1):39-49.
1997: Uchihara T; Akiyama H; Kondo H; Ikeda K
Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain.
Stroke; a journal of cerebral circulation 1997;28(10):1948-50.
1997: Meyer J S; Akiyama H; Mortel K F; Konno S; Margishvili G M
Human aging: risk factors for cerebral atrophy.
Annals of the New York Academy of Sciences 1997;826():483-9.
1997: Ikeda K; Akiyama H; Arai T; Sahara N; Mori H; Usami M; Sakata M; Mizutani T; Wakabayashi K; Takahashi H
A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele.
Annals of neurology 1997;41(5):693-5.
1997: Hino H; Mori K; Yoshihara Y; Iseki E; Akiyama H; Nishimura T; Ikeda K; Kosaka K
Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease.
Brain research 1997;753(2):353-7.
1997: Nishimura T; Ikeda K; Akiyama H; Arai T; Kondo H; Okochi M; Furiya Y; Mori H; Oda T; Kato M; Iseki E
Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene.
Neuroscience letters 1997;224(3):169-72.
1997: Akiyama H
[Thrombin deposition in brains of patients with Alzheimer's disease--activation of the coagulation system in the central nervous system]
Rinsho byori. The Japanese journal of clinical pathology 1997;Suppl 104():117-23.
1997: Kawamata T; Akiguchi I; Yagi H; Irino M; Sugiyama H; Akiyama H; Shimada A; Takemura M; Ueno M; Kitabayashi T; Ohnishi K; Seriu N; Higuchi K; Hosokawa M; Takeda T
Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory.
Experimental gerontology 1997;32(1-2):161-9.
1996: Shirai T; Meyer J S; Akiyama H; Mortel K F; Wills P M
Acetazolamide testing of cerebral vasodilator capacity provokes "vascular" but not tension headaches.
Headache 1996;36(10):589-94.
1996: Katsuragi T; Iseki E; Kosaka K; Nishimura T; Akiyama H; Ikeda K; Kato M
Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain.
Neuroscience letters 1996;219(3):207-10.
1996: Akiyama H; Kondo H; Mori H; Kametani F; Nishimura T; Ikeda K; Kato M; McGeer P L
The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients.
Neuroscience letters 1996;219(2):115-8.
1996: Li F; Iseki E; Kosaka K; Nishimura T; Akiyama H; Kato M
Progressive supranuclear palsy with fronto-temporal atrophy and various tau-positive abnormal structures.
Clinical neuropathology 1996;15(6):319-23.
1996: Ikeda K; Akiyama H; Iritani S; Kase K; Arai T; Niizato K; Kuroki N; Kosaka K
Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review.
Acta neuropathologica 1996;92(5):534-9.
1996: Iseki E; Odawara T; Li F; Kosaka K; Nishimura T; Akiyama H; Ikeda K
Age-related ubiquitin-positive granular structures in non-demented subjects and neurodegenerative disorders.
Journal of the neurological sciences 1996;142(1-2):25-9.
1996: Schwab C; Steele J C; Akiyama H; McGeer P L
Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam.
Acta neuropathologica 1996;92(4):378-85.
1996: Akiyama H; Tooyama I
[LRP (alpha 2-macroglobulin receptor) and Alzheimer lesions]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(10):1470-5.
1996: Goto K; Mochizuki H; Imai H; Akiyama H; Mizuno Y
An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys.
Brain research 1996;724(1):125-8.
1996: Akiyama H; Schwab C; Kondo H; Mori H; Kametani F; Ikeda K; McGeer P L
Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein.
Neuroscience letters 1996;206(2-3):169-72.
1996: Meyer J S; Shirai T; Akiyama H
Neuroimaging for differentiating vascular from Alzheimer's dementias.
Cerebrovascular and brain metabolism reviews 1996;8(1):1-10.
1995: Nishimura T; Ikeda K; Akiyama H; Kondo H; Kato M; Li F; Iseki E; Kosaka K
Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy.
Neuroscience letters 1995;201(2):123-6.
1995: Akiyama H; Kondo H; Ikeda K; Arai T; Kato M; McGleer P L
Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue.
Neuroscience letters 1995;202(1-2):29-32.
1995: Nishimura T; Akiyama H; Yonehara S; Kondo H; Ikeda K; Kato M; Iseki E; Kosaka K
Fas antigen expression in brains of patients with Alzheimer-type dementia.
Brain research 1995;695(2):137-45.
1995: Ikeda K; Akiyama H; Kondo H; Arai T; Arai N; Yagishita S
Numerous glial fibrillary tangles in oligodendroglia in cases of subacute sclerosing panencephalitis with neurofibrillary tangles.
Neuroscience letters 1995;194(1-2):133-5.
1995: Odawara T; Iseki E; Kosaka K; Akiyama H; Ikeda K; Yamamoto T
Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders.
Neuroscience letters 1995;192(3):145-8.
1995: Ikeda K; Akiyama H; Kondo H; Haga C; Tanno E; Tokuda T; Ikeda S
Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles.
Acta neuropathologica 1995;90(6):620-5.
1995: Oda T; Ikeda K; Akamatsu W; Iwabuchi K; Akiyama H; Kondo H; Seta K; Kato Y; Kogure T; Hori K
[An autopsy case of corticobasal degeneration clinically misdiagnosed as Pick's disease]
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 1995;97(9):757-69.
1995: Schwab C; Steele J C; Akiyama H; McGeer E G; McGeer P L
Relationship of amyloid beta/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia.
Acta neuropathologica 1995;90(3):287-98.
1995: Uchihara T; Kondo H; Akiyama H; Ikeda K
White matter amyloid in Alzheimer's disease brain.
Acta neuropathologica 1995;90(1):51-6.
1995: Ikeda K; Akiyama H; Kondo H; Haga C
A study of dementia with argyrophilic grains. Possible cytoskeletal abnormality in dendrospinal portion of neurons and oligodendroglia.
Acta neuropathologica 1995;89(5):409-14.
1994: Akiyama H
[Alzheimer's disease and the immune system response]
Nippon rinsho. Japanese journal of clinical medicine 1994;52(11):2990-4.
1994: Akiyama H
Inflammatory response in Alzheimer's disease.
The Tohoku journal of experimental medicine 1994;174(3):295-303.
1994: Hara Y; Tooyama I; Yasuhara O; Akiyama H; McGeer P L; Handa J; Kimura H
Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction.
Brain research 1994;664(1-2):101-7.
1994: Haga C; Ikeda K; Iwabuchi K; Akiyama H; Kondoh H; Kosaka K
Methenamine-silver staining: a simple and sensitive staining method for senile plaques and neurofibrillary tangles.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1994;69(5):295-300.
1994: Ikeda K; Akiyama H; Haga C; Kondo H; Arima K; Oda T
Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy.
Neuroscience letters 1994;174(2):157-9.
1994: Itagaki S; Akiyama H; Saito H; McGeer P L
Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.
Brain research 1994;645(1-2):78-84.
1994: McGeer P L; Walker D G; Akiyama H; Yasuhara O; McGeer E G
Involvement of microglia in Alzheimer's disease.
Neuropathology and applied neurobiology 1994;20(2):191-2.
1994: Akiyama H; Ikeda K; Katoh M; McGeer E G; McGeer P L
Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue.
Journal of neuroimmunology 1994;50(2):195-201.
1994: Akiyama H; Nishimura T; Kondo H; Ikeda K; Hayashi Y; McGeer P L
Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis.
Brain research 1994;639(1):171-4.
1994: Yasuhara O; Akiyama H; McGeer E G; McGeer P L
Immunohistochemical localization of hyaluronic acid in rat and human brain.
Brain research 1994;635(1-2):269-82.
1994: Akiyama H; Tooyama I; Kondo H; Ikeda K; Kimura H; McGeer E G; McGeer P L
Early response of brain resident microglia to kainic acid-induced hippocampal lesions.
Brain research 1994;635(1-2):257-68.
1993: Akiyama H; Ikeda K; Kondo H; Kato M; McGeer P L
Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease.
Neuroscience letters 1993;164(1-2):233-5.
1993: Akiyama H; Tooyama I; Kawamata T; Ikeda K; McGeer P L
Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease.
Brain research 1993;632(1-2):249-59.
1993: Ikeda K; Akiyama H; Kondo H; Ikeda K
Anti-tau-positive glial fibrillary tangles in the brain of postencephalitic parkinsonism of Economo type.
Neuroscience letters 1993;162(1-2):176-8.
1993: Tomimoto H; Akiguchi I; Akiyama H; Kimura J; Yanagihara T
T-cell infiltration and expression of MHC class II antigen by macrophages and microglia in a heterogeneous group in leukoencephalopathy.
The American journal of pathology 1993;143(2):579-86.
1993: Tooyama I; Kawamata T; Akiyama H; Moestrup S K; Gliemann J; McGeer P L
Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;18(1-2):153-60.
1993: McGeer P L; Kawamata T; Walker D G; Akiyama H; Tooyama I; McGeer E G
Microglia in degenerative neurological disease.
Glia 1993;7(1):84-92.
1993: Akiyama H; Yamada T; McGeer P L; Kawamata T; Tooyama I; Ishii T
Columnar arrangement of beta-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease.
Acta neuropathologica 1993;85(4):400-3.
1993: Akiyama H; Kawamata T; Yamada T; Tooyama I; Ishii T; McGeer P L
Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders.
Acta neuropathologica 1993;85(6):628-34.
1993: Yamada T; Calne D B; Akiyama H; McGeer E G; McGeer P L
Further observations on Tau-positive glia in the brains with progressive supranuclear palsy.
Acta neuropathologica 1993;85(3):308-15.
1992: Ikeda K; Haga C; Akiyama H; Kase K; Iritani S
Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles.
Neuroscience letters 1992;148(1-2):126-8.
1992: Akiyama H; Ikeda K; Kondo H; McGeer P L
Thrombin accumulation in brains of patients with Alzheimer's disease.
Neuroscience letters 1992;146(2):152-4.
1992: McGeer P L; Akiyama H; Kawamata T; Yamada T; Walker D G; Ishii T
Immunohistochemical localization of beta-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy.
Journal of neuroscience research 1992;31(3):428-42.
1992: Kawamata T; Akiyama H; Yamada T; McGeer P L
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.
The American journal of pathology 1992;140(3):691-707.
1992: Ikeda K; Akiyama H; Haga C; Haga S
Evidence that neurofibrillary tangles undergo glial modification.
Acta neuropathologica 1992;85(1):101-4.
1991: McGeer P L; McGeer E G; Kawamata T; Yamada T; Akiyama H
Reactions of the immune system in chronic degenerative neurological diseases.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3 Suppl):376-9.
1991: Yamada T; Akiyama H; McGeer P L
Two types of spheroid bodies in the nigral neurons in Parkinson's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3):287-94.
1991: Akiyama H; Yamada T; Kawamata T; McGeer P L
Association of amyloid P component with complement proteins in neurologically diseased brain tissue.
Brain research 1991;548(1-2):349-52.
1991: Akiyama H; Kawamata T; Dedhar S; McGeer P L
Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue.
Journal of neuroimmunology 1991;32(1):19-28.
1991: McGeer P L; Walker D G; Akiyama H; Kawamata T; Guan A L; Parker C J; Okada N; McGeer E G
Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain.
Brain research 1991;544(2):315-9.
1991: Tooyama I; Akiyama H; McGeer P L; Hara Y; Yasuhara O; Kimura H
Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients.
Neuroscience letters 1991;121(1-2):155-8.
1990: McGeer E G; McGeer P L; Harrop R; Akiyama H; Kamo H
Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in Alzheimer's disease.
Journal of neuroscience research 1990;27(4):612-9.
1990: Kimura H; Tago H; Akiyama H; Hersh L B; Tooyama I; McGeer P L
Choline acetyltransferase immunopositive neurons in the lateral septum.
Brain research 1990;533(1):165-70.
1990: Akiyama H; McGeer P L
Brain microglia constitutively express beta-2 integrins.
Journal of neuroimmunology 1990;30(1):81-93.
1990: Tooyama I; Kimura H; Akiyama H; McGeer P L
Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease.
Brain research 1990;523(2):273-80.
1990: Akiyama H; Kaneko T; Mizuno N; McGeer P L
Distribution of phosphate-activated glutaminase in the human cerebral cortex.
The Journal of comparative neurology 1990;297(2):239-52.
1990: Yamada T; Akiyama H; McGeer P L
Complement-activated oligodendroglia: a new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d.
Neuroscience letters 1990;112(2-3):161-6.
1990: Weinstein D L; Walker D G; Akiyama H; McGeer P L
Herpes simplex virus type I infection of the CNS induces major histocompatibility complex antigen expression on rat microglia.
Journal of neuroscience research 1990;26(1):55-65.
1990: McGeer E G; Peppard R P; McGeer P L; Tuokko H; Crockett D; Parks R; Akiyama H; Calne D B; Beattie B L; Harrop R
18Fluorodeoxyglucose positron emission tomography studies in presumed Alzheimer cases, including 13 serial scans.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1990;17(1):1-11.
1990: Kaneko T; Akiyama H; Nagatsu I; Mizuno N
Immunohistochemical demonstration of glutaminase in catecholaminergic and serotoninergic neurons of rat brain.
Brain research 1990;507(1):151-4.
1990: Akiyama H; Tago H; Itagaki S; McGeer P L
Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease.
Acta neuropathologica 1990;79(5):537-44.
1989: McGeer P L; Akiyama H; Itagaki S; McGeer E G
Activation of the classical complement pathway in brain tissue of Alzheimer patients.
Neuroscience letters 1989;107(1-3):341-6.
1989: Itagaki S; McGeer P L; Akiyama H; Beattie B L; Walker D G; Moore G R; McGeer E G
A case of adult-onset dementia with argyrophilic grains.
Annals of neurology 1989;26(5):685-9.
1989: McGeer P L; Akiyama H; Itagaki S; McGeer E G
Immune system response in Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):516-27.
1989: McGeer E G; McGeer P L; Akiyama H; Harrop R
Cortical glutaminase, beta-glucuronidase and glucose utilization in Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):511-5.
1989: Itagaki S; McGeer P L; Akiyama H; Zhu S; Selkoe D
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.
Journal of neuroimmunology 1989;24(3):173-82.
1989: Tago H; McGeer P L; McGeer E G; Akiyama H; Hersh L B
Distribution of choline acetyltransferase immunopositive structures in the rat brainstem.
Brain research 1989;495(2):271-97.
1989: Akiyama H; McGeer P L
Microglial response to 6-hydroxydopamine-induced substantia nigra lesions.
Brain research 1989;489(2):247-53.
1989: Akiyama H; Harrop R; McGeer P L; Peppard R; McGeer E G
Crossed cerebellar and uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease.
Neurology 1989;39(4):541-8.
1989: Akiyama H; McGeer P L; Itagaki S; McGeer E G; Kaneko T
Loss of glutaminase-positive cortical neurons in Alzheimer's disease.
Neurochemical research 1989;14(4):353-8.
1988: McGeer P L; Itagaki S; Akiyama H; McGeer E G
Rate of cell death in parkinsonism indicates active neuropathological process.
Annals of neurology 1988;24(4):574-6.
1988: Itagaki S; McGeer P L; Akiyama H
Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue.
Neuroscience letters 1988;91(3):259-64.
1988: Akiyama H; Itagaki S; McGeer P L
Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions.
Journal of neuroscience research 1988;20(2):147-57.
1987: Sugiyama H; Akiyama H; Akiguchi I; Kameyama M; Takeda T
[Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study]
Rinsho shinkeigaku = Clinical neurology 1987;27(7):841-5.
1987: Kaneko T; Akiyama H; Mizuno N
Immunohistochemical demonstration of glutamate dehydrogenase in astrocytes.
Neuroscience letters 1987;77(2):171-5.
1986: Akiyama H; Kameyama M; Akiguchi I; Sugiyama H; Kawamata T; Fukuyama H; Kimura H; Matsushita M; Takeda T
Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM).
Acta neuropathologica 1986;72(2):124-9.

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