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Erik Schaefer

Research Profile

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Marta Rubio; Daniele Avitabile; Kimberlee Fischer; Gregory Emmanuel; Natalie Gude; Shigeki Miyamoto; Shikha Mishra; Erik M Schaefer; Joan Heller Brown; Mark A Sussman
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes.
Min Li; Paolo Luraghi; Augustin Amour; Xiao-Dong Qian; Paul S Carter; C J Clark; Angela Deakin; Jane Denyer; Clare I Hobbs; Mark Surby; Vipul K Patel; Erik M Schaefer
Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.
John Muraski; Kimberlee M Fischer; Weitao Wu; Travis Cottage; Pearl Quijada; Matt Mason; Shabana Din; Natalie Gude; Roberto Alvarez; Marcello Rota; Jan Kajstura; Zeping Wang; Erik M Schaefer; Xiongen Chen; Scott MacDonnel; Nancy Magnuson; Steven R Houser; Piero Anversa; Mark A Sussman
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload.

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All Publications

2009: Marta Rubio; Daniele Avitabile; Kimberlee Fischer; Gregory Emmanuel; Natalie Gude; Shigeki Miyamoto; Shikha Mishra; Erik M Schaefer; Joan Heller Brown; Mark A Sussman
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes.
Journal of molecular and cellular cardiology 2009;47(1):96-103.
2009: Min Li; Paolo Luraghi; Augustin Amour; Xiao-Dong Qian; Paul S Carter; C J Clark; Angela Deakin; Jane Denyer; Clare I Hobbs; Mark Surby; Vipul K Patel; Erik M Schaefer
Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates.
Analytical biochemistry 2009;384(1):56-67.
2008: John Muraski; Kimberlee M Fischer; Weitao Wu; Travis Cottage; Pearl Quijada; Matt Mason; Shabana Din; Natalie Gude; Roberto Alvarez; Marcello Rota; Jan Kajstura; Zeping Wang; Erik M Schaefer; Xiongen Chen; Scott MacDonnel; Nancy Magnuson; Steven R Houser; Piero Anversa; Mark A Sussman
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13889-94.
2008: Sailay Siddiqi; Natalie Gude; Toru Hosoda; John Muraski; Marta Rubio; Gregory Emmanuel; Jenna Fransioli; Serena Vitale; Carola Parolin; D'Amario Domenico; Erik M Schaefer; Jan Kajstura; Annarosa Leri; Piero Anversa; Mark A Sussman
Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge.
Circulation research 2008;103(1):89-97.
2008: Natalie A Gude; Gregory Emmanuel; Weitao Wu; Travis Cottage; Kimberlee Fischer; Pearl Quijada; John Muraski; Roberto Alvarez; Marta Rubio; Erik M Schaefer; Mark A Sussman
Activation of Notch-mediated protective signaling in the myocardium.
Circulation research 2008;102(9):1025-35.
2008: Jenna Fransioli; Brandi Bailey; Natalie A Gude; Travis Cottage; John Muraski; Gregory Emmanuel; Weitao Wu; Roberto Alvarez; Marta Rubio; Sergio Ottolenghi; Erik M Schaefer; Mark A Sussman
Evolution of the c-kit-positive cell response to pathological challenge in the myocardium.
Stem cells (Dayton, Ohio) 2008;26(5):1315-24.
2008: Zengqiang Yuan; Esther B E Becker; Paola Merlo; Tomoko Yamada; Sara DiBacco; Yoshiyuki Konishi; Erik M Schaefer; Azad Bonni
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
Science (New York, N.Y.) 2008;319(5870):1665-8.
2007: John Muraski; Marcello Rota; Yu Misao; Jenna Fransioli; Travis Cottage; Natalie Gude; Grazia Esposito; Francesca Delucchi; Michael Arcarese; Roberto Alvarez; Sailay Siddiqi; Gregory N Emmanuel; Weitao Wu; Kimberlee Fischer; Joshua Martindale; Christopher C Glembotski; Annarosa Leri; Jan Kajstura; Nancy Magnuson; Anton Berns; Remus M Beretta; Steven R Houser; Erik M Schaefer; Piero Anversa; Mark A Sussman
Pim-1 regulates cardiomyocyte survival downstream of Akt.
Nature medicine 2007;13(12):1467-75.
2006: Natalie Gude; John Muraski; Marta Rubio; Jan Kajstura; Erik M Schaefer; Piero Anversa; Mark A Sussman
Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population.
Circulation research 2006;99(4):381-8.
2006: Mingguang Li; Bjarki Stefansson; Weiping Wang; Erik M Schaefer; David L Brautigan
Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle.
Cellular signalling 2006;18(8):1318-26.
2006: Anjana Nayal; Donna J Webb; Claire M Brown; Erik M Schaefer; Miguel Vicente-Manzanares; Alan Rick Horwitz
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics.
The Journal of cell biology 2006;173(4):587-9.
2005: Takahiro Kato; John Muraski; Yan Chen; Yasuyuki Tsujita; Jason Wall; Christopher C Glembotski; Erik M Schaefer; Mary Beckerle; Mark A Sussman
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.
The Journal of clinical investigation 2005;115(10):2716-30.
2005: Joseph Krueger; Fan-Li Chou; Angela Glading; Erik M Schaefer; Mark H Ginsberg
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.
Molecular biology of the cell 2005;16(8):3552-61.
2005: Chunlei Gao; Erik M Schaefer; Montaha Lakkis; Scott D Blystone
Beta3 tyrosine phosphorylation and alphavbeta3-mediated adhesion are required for Vav1 association and Rho activation in leukocytes.
The Journal of biological chemistry 2005;280(15):15422-9.
2005: Patrick C Ma; Erik M Schaefer; James G Christensen; Ravi Salgia
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2312-9.
2005: Patrick C Ma; Ramasamy Jagadeeswaran; Simha Jagadeesh; Maria Tretiakova; Vidya Nallasura; Edward A Fox; Mark Hansen; Erik M Schaefer; Katsuhiko Naoki; Alan Lader; William Richards; David J Sugarbaker; Aliya N Husain; James G Christensen; Ravi Salgia
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.
Cancer research 2005;65(4):1479-88.
2004: Jaime Melendez; Christopher Turner; Hava Avraham; Susan F Steinberg; Erik M Schaefer; Mark A Sussman
Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin.
The Journal of biological chemistry 2004;279(51):53516-23.
2004: Rebecca Stockton; Erik M Schaefer; Martin A Schwartz
p21-activated kinase regulates endothelial permeability through modulation of contractility.
The Journal of biological chemistry 2004;279(45):46621-30.
2004: Zhiyong Zhang; Gonzalo Izaguirre; Siang-Yo Lin; Hwa Young Lee; Erik M Schaefer; Beatrice Haimovich
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.
Molecular biology of the cell 2004;15(9):4234-47.
2004: Vitalyi O Rybin; Jianfen Guo; Abdelkarim Sabri; Hasnae Elouardighi; Erik M Schaefer; Susan F Steinberg
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes.
The Journal of biological chemistry 2004;279(18):19350-61.
2004: Isao Shiraishi; Jaime Melendez; Youngkeun Ahn; Maryanne Skavdahl; Elizabeth Murphy; Sara Welch; Erik M Schaefer; Kenneth Walsh; Anthony Rosenzweig; Daniele Torella; Daria Nurzynska; Jan Kajstura; Annarosa Leri; Piero Anversa; Mark A Sussman
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.
Circulation research 2004;94(7):884-91.
2004: Surjit K. Chandhoke; Matthew Williams; Erik M Schaefer; Linda Zorn; Scott D Blystone
Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts.
Journal of cell science 2004;117(Pt 8):1431-41.
2004: Eva H Lin; Angela Y Hui; Jalna A Meens; Eric A Tremblay; Erik M Schaefer; Bruce E Elliott
Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells.
Experimental cell research 2004;293(1):1-13.
2004: Rinat Tabakman; Hao Jiang; Erik M Schaefer; Robert A Levine; Philip Lazarovici
Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model.
Journal of molecular neuroscience : MN 2004;22(3):237-50.
2003: Vered Givant-Horwitz; Ben Davidson; Philip Lazarovici; Erik M Schaefer; Jahn M Nesland; Claes G Tropé; Reuven Reich
Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions.
Gynecologic oncology 2003;91(1):160-72.
2003: Julie A Head; Dongyan Jiang; Min Li; Lynda J Zorn; Erik M Schaefer; Thomas J Parsons; Scott A Weed
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Molecular biology of the cell 2003;14(8):3216-29.
2003: Takashi Kijima; Gautam Maulik; Patrick C Ma; Priya Madhiwala; Erik M Schaefer; Ravi Salgia
Fibronectin enhances viability and alters cytoskeletal functions (with effects on the phosphatidylinositol 3-kinase pathway) in small cell lung cancer.
Journal of cellular and molecular medicine 2003;7(2):157-64.
2003: Kristina S Kovacina; Grace Y Park; Sun Sik Bae; Andrew W Guzzetta; Erik M Schaefer; Morris J Birnbaum; Richard A Roth
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.
The Journal of biological chemistry 2003;278(12):10189-94.
2003: Ben Davidson; Vered Givant-Horwitz; Philip Lazarovici; Björn Risberg; Jahn M Nesland; Claes G Trope; Erik M Schaefer; Reuven Reich
Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma.
Clinical & experimental metastasis 2003;20(7):621-31.
2002: Ingeborg Hers; Caroline J Bell; Alastair W Poole; Donyang Jiang; Richard M Denton; Erik M Schaefer; Jeremy M Tavaré
Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.
The Biochemical journal 2002;368(Pt 3):875-84.
2002: Asako Tsubouchi; Junko Sakakura; Ryohei Yagi; Yuichi Mazaki; Erik M Schaefer; Hajime Yano; Hisataka Sabe
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.
The Journal of cell biology 2002;159(4):673-83.
2002: Jaime Melendez; Sara Welch; Erik M Schaefer; Christine S Moravec; Shalom Avraham; Hava Avraham; Mark A Sussman
Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling.
The Journal of biological chemistry 2002;277(47):45203-10.
2002: Gautam Maulik; P Madhiwala; S Brooks; Patrick C Ma; Takashi Kijima; Elena V Tibaldi; Erik M Schaefer; Kalindi Parmar; Ravi Salgia
Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.
Journal of cellular and molecular medicine 2002;6(4):539-53.
2002: Sara Welch; David M Plank; Sandra Witt; Betty J Glascock; Erik M Schaefer; Stefano Chimenti; Anna Maria Andreoli; Federica Limana; Annarosa Leri; Jan Kajstura; Piero Anversa; Mark A Sussman
Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice.
Circulation research 2002;90(6):641-8.
2002: Laura Moro; Laura Dolce; Sara Cabodi; Elena Bergatto; Elisabetta Boeri Erba; Monica Smeriglio; Emilia Turco; SAVERIO FRANCESCO RETTA; Maria Gabriella Giuffrida; Mascia Venturino; Jasminka Godovac-Zimmermann; Amedeo Conti; Erik M Schaefer; Laura Beguinot; Carlo Tacchetti; Paolo Gaggini; Lorenzo Silengo; Guido Tarone; Paola Defilippi
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.
The Journal of biological chemistry 2002;277(11):9405-14.
2002: Gautam Maulik; Takashi Kijima; Patrick C Ma; Sudip Ghosh; Jeffrey Lin; Geoffrey I Shapiro; Erik M Schaefer; Elena V Tibaldi; Bruce E Johnson; Ravi Salgia
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):620-7.
2002: Teruo Iwasaki; Atsushi Nakata; Mutsuko Mukai; Kiyoko Shinkai; Hajime Yano; Hisataka Sabe; Erik M Schaefer; Masaharu Tatsuta; Tohru Tsujimura; Nobuyuki Terada; Eizo Kakishita; Hitoshi Akedo
Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration.
International journal of cancer. Journal international du cancer 2002;97(3):330-5.
2001: Michael D Schaller; Erik M Schaefer
Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.
The Biochemical journal 2001;360(Pt 1):57-66.
2001: D Ilić; Olga Genbacev; Fang Jin; Eduardo Caceres; EA Almeida; V Bellingard-Dubouchaud; Erik M Schaefer; Caroline Damsky; Susan J Fisher
Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro.
The American journal of pathology 2001;159(1):93-108.
2001: Patrick D Lyons; Jill M Dunty; Erik M Schaefer; Michael D Schaller
Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
The Journal of biological chemistry 2001;276(26):24422-31.
2001: D Camper-Kirby; Sara Welch; A Walker; Isao Shiraishi; K D Setchell; Erik M Schaefer; Jan Kajstura; Piero Anversa; Mark A Sussman
Myocardial Akt activation and gender: increased nuclear activity in females versus males.
Circulation research 2001;88(10):1020-7.
2001: K Nakamura; Hajime Yano; Erik M Schaefer; Hisataka Sabe
Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.
Oncogene 2001;20(21):2626-35.
2001: M Janulis; Nicholas Trakul; G Greene; Erik M Schaefer; J D Lee; Marsha Rich Rosner
A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
Molecular and cellular biology 2001;21(6):2235-47.
2001: A Ma; Alan Richardson; Erik M Schaefer; Thomas J Parsons
Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).
Molecular biology of the cell 2001;12(1):1-12.
2000: K Nakamura; Hajime Yano; H Uchida; Shigeru Hashimoto; Erik M Schaefer; Hisataka Sabe
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells.
The Journal of biological chemistry 2000;275(35):27155-64.
2000: Krister Wennerberg; Annika Armulik; T Sakai; M Karlsson; Reinhard Fässler; Erik M Schaefer; Deane F Mosher; Staffan Johansson
The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation.
Molecular and cellular biology 2000;20(15):5758-65.
2000: DJ Sieg; Christof R Hauck; Dusko Ilic; CK Klingbeil; Erik M Schaefer; Caroline Damsky; David D Schlaepfer
FAK integrates growth-factor and integrin signals to promote cell migration.
Nature cell biology 2000;2(5):249-56.
2000: Mark A Sussman; Sara Welch; A Walker; Raisa Klevitsky; TE Hewett; Robert L Price; Erik M Schaefer; Karen Yager
Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1.
The Journal of clinical investigation 2000;105(7):875-86.
1998: Erik M Schaefer; Y Gao; D Brandenburg; W Thevis; HG Gattner; L E Ellis; B A Levine
Localisation and dynamics of receptor-insulin contacts by NMR studies on the human insulin receptor ectodomain.
Biochemical Society transactions 1998;26(3):S294.
1998: Erik M Schaefer; S Guimond
Detection of protein tyrosine kinase activity using a high-capacity streptavidin-coated membrane and optimized biotinylated peptide substrates.
Analytical biochemistry 1998;261(1):100-12.
1998: KM Walton; R DiRocco; B A Bartlett; EJ Koury; V R Marcy; B Jarvis; Erik M Schaefer; RV Bhat
Activation of p38MAPK in microglia after ischemia.
Journal of neurochemistry 1998;70(4):1764-7.
1998: Heather L Brownell; N B Lydon; Erik M Schaefer; Thomas M Roberts; Leda Raptis
Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives.
DNA and cell biology 1998;17(3):265-74.
1998: K i Nagata; A Puls; Clare Futter; P Aspenstrom; Erik M Schaefer; T Nakata; N Hirokawa; Alan Hall
The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.
The EMBO journal 1998;17(1):149-58.
1997: Shuichan Xu; Shih Khoo; A Dang; S Witt; V Do; E Zhen; Erik M Schaefer; Melanie H Cobb
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1618-25.
1997: Leda Raptis; Heather L Brownell; Y Lu; Thomas Preston; R P Narsimhan; S Anderson; Erik M Schaefer; T Haliotis
v-Ras and v-Raf block differentiation of transformable C3H10T1/2-derived preadipocytes at lower levels than required for neoplastic transformation.
Experimental cell research 1997;235(1):188-97.
1997: Andrei V Khokhlatchev; Shuichan Xu; J English; P Wu; Erik M Schaefer; Melanie H Cobb
Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases.
The Journal of biological chemistry 1997;272(17):11057-62.
1996: Michael A White; T Vale; J H Camonis; Erik M Schaefer; Michael Wigler
A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation.
The Journal of biological chemistry 1996;271(28):16439-42.
1994: Erik M Schaefer; V Viard; J Morin; P Ferré; L Pénicaud; P Ramos; S D Maika; L Ellis; R E Hammer
A new transgenic mouse model of chronic hyperglycemia.
Diabetes 1994;43(1):143-53.
1992: Erik M Schaefer; H P Erickson; M Federwisch; Axel Wollmer; L Ellis
Structural organization of the human insulin receptor ectodomain.
The Journal of biological chemistry 1992;267(32):23393-402.
1992: M Fabry; Erik M Schaefer; L Ellis; E Kojro; F Fahrenholz; D Brandenburg
Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin.
The Journal of biological chemistry 1992;267(13):8950-6.
1990: Erik M Schaefer; K Siddle; L Ellis
Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.
The Journal of biological chemistry 1990;265(22):13248-53.
1988: Erik M Schaefer; J M Moehring; T J Moehring
Binding of diphtheria toxin to CHO-K1 and Vero cells is dependent on cell density.
Journal of cellular physiology 1988;135(3):407-15.