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Richard Mailman
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40
Nichols, David
19
Lawler, Cindy
15
Watts, Val
11
Lewis, Mechelle
9
Wyrick, SD
6
Gilmore, John
4
Lieberman, Jeffrey
4
Booth, Raymond
4
Huang, X
3
Huang, Xuemei
3
Baldessarini, Ross
3
Kilts, Jason
3
Kula, Nora
3
Leonard, Sarah
3
Prioleau, C
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All Publications
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2009: Brown Justin T; Kant Andrew; Mailman Richard B
Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: application in GPCR-mediated adenylate cyclase assays.
Journal of neuroscience methods 2009;177(2):261-6.
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2008: Huang Xuemei; Abbott Robert D; Petrovitch Helen; Mailman Richard B; Ross G Webster
Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study.
Movement disorders : official journal of the Movement Disorder Society 2008;23(7):1013-8.
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2007: Mailman Richard B
GPCR functional selectivity has therapeutic impact.
Trends in pharmacological sciences 2007;28(8):390-6.
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2007: Mu Qiwen; Johnson Kevin; Morgan Paul S; Grenesko Emily L; Molnar Christine E; Anderson Berry; Nahas Ziad; Kozel F Andrew; Kose Samet; Knable Michael; Fernandes Prabhavathi; Nichols David E; Mailman Richard B; George Mark S
A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia.
Schizophrenia research 2007;94(1-3):332-41.
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2007: George Mark S; Molnar Christine E; Grenesko Emily L; Anderson Berry; Mu Qiwen; Johnson Kevin; Nahas Ziad; Knable Michael; Fernandes Prabhavathi; Juncos Jorge; Huang Xuemei; Nichols David E; Mailman Richard B
A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia.
Schizophrenia research 2007;93(1-3):42-50.
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2007: Lewis M M; Slagle C G; Smith A B; Truong Y; Bai P; McKeown M J; Mailman R B; Belger A; Huang X
Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries.
Neuroscience 2007;147(1):224-35.
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2007: Huang Xuemei; Chen Honglei; Miller William C; Mailman Richard B; Woodard Jennifer L; Chen Peter C; Xiang Dong; Murrow Richard W; Wang Yi-Zhe; Poole Charles
Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2007;22(3):377-81.
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2007: Ryman-Rasmussen Jessica P; Griffith Adam; Oloff Scott; Vaidehi Nagarajan; Brown Justin T; Goddard William A; Mailman Richard B
Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors.
Neuropharmacology 2007;52(2):562-75.
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2007: Urban Jonathan D; Clarke William P; von Zastrow Mark; Nichols David E; Kobilka Brian; Weinstein Harel; Javitch Jonathan A; Roth Bryan L; Christopoulos Arthur; Sexton Patrick M; Miller Keith J; Spedding Michael; Mailman Richard B
Functional selectivity and classical concepts of quantitative pharmacology.
The Journal of pharmacology and experimental therapeutics 2007;320(1):1-13.
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2007: Urban Jonathan D; Vargas Gabriel A; von Zastrow Mark; Mailman Richard B
Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(1):67-77.
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2007: Mailman Richard B; Huang Xuemei
Dopamine receptor pharmacology.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2007;83():77-105.
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2006: Leonard Sarah K; Ferry-Leeper Penelope; Mailman Richard B
Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors.
Brain research 2006;1117(1):25-37.
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2006: Lewis M M; Huang X; Nichols D E; Mailman R B
D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinson's disease.
CNS & neurological disorders drug targets 2006;5(3):345-53.
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2005: Oloff Scott; Mailman Richard B; Tropsha Alexander
Application of validated QSAR models of D1 dopaminergic antagonists for database mining.
Journal of medicinal chemistry 2005;48(23):7322-32.
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2005: Padilla Stephanie; Marshall Renée S; Hunter Deborah L; Oxendine Sharon; Moser Virginia C; Southerland Stanley B; Mailman Richard B
Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(1):161-71.
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2005: Ryman-Rasmussen Jessica P; Nichols David E; Mailman Richard B
Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists.
Molecular pharmacology 2005;68(4):1039-48.
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2004: Gay Elaine A; Urban Jonathan D; Nichols David E; Oxford Gerry S; Mailman Richard B
Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states.
Molecular pharmacology 2004;66(1):97-105.
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2004: Grubbs Russell A; Lewis Mechelle M; Owens-Vance Connie; Gay Elaine A; Jassen Amy K; Mailman Richard B; Nichols David E
8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms.
Bioorganic & medicinal chemistry 2004;12(6):1403-12.
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2004: Sit Sing-Yuen; Xie Kai; Jacutin-Porte Swanee; Boy Kenneth M; Seanz James; Taber Matthew T; Gulwadi Amit G; Korpinen Carolyn D; Burris Kevin D; Molski Thaddeus F; Ryan Elaine; Xu Cen; Verdoorn Todd; Johnson Graham; Nichols David E; Mailman Richard B
Synthesis and SAR exploration of dinapsoline analogues.
Bioorganic & medicinal chemistry 2004;12(4):715-34.
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2003: Leonard Sarah K; Anderson Carl M; Lachowicz Jean E; Schulz David W; Kilts Clinton D; Mailman Richard B
Amygdaloid D1 receptors are not linked to stimulation of adenylate cyclase.
Synapse (New York, N.Y.) 2003;50(4):320-33.
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2003: Shapiro David A; Renock Sean; Arrington Elaine; Chiodo Louis A; Liu Li-Xin; Sibley David R; Roth Bryan L; Mailman Richard
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(8):1400-11.
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2003: Qandil Amjad M; Lewis Mechelle M; Jassen Amy; Leonard Sarah K; Mailman Richard B; Nichols David E
Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands.
Bioorganic & medicinal chemistry 2003;11(7):1451-64.
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2002: Andersson Candace; Hamer Robert M; Lawler Cindy P; Mailman Richard B; Lieberman Jeffrey A
Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(2):143-51.
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2002: Kilts Jason D; Connery Hilary S; Arrington Elaine G; Lewis Mechelle M; Lawler Cindy P; Oxford Gerry S; O'Malley Karen L; Todd Richard D; Blake Bonita L; Nichols David E; Mailman Richard B
Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1179-89.
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2002: Mottola David M; Kilts Jason D; Lewis Mechelle M; Connery Hilary S; Walker Q David; Jones Sara R; Booth Raymond G; Hyslop Deborah K; Piercey Monford; Wightman R Mark; Lawler Cindy P; Nichols David E; Mailman Richard B
Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1166-78.
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2001: Mailman R; Huang X; Nichols D E
Parkinson's disease and D1 dopamine receptors.
Current opinion in investigational drugs (London, England : 2000) 2001;2(11):1582-91.
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2001: Miyamoto S; Mailman R B; Lieberman J A; Duncan G E
Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors.
Brain research 2001;894(2):167-80.
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2001: Montague D M; Striplin C D; Overcash J S; Drago J; Lawler C P; Mailman R B
Quantification of D1B(D5) receptors in dopamine D1A receptor-deficient mice.
Synapse (New York, N.Y.) 2001;39(4):319-22.
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2001: Gulwadi A G; Korpinen C D; Mailman R B; Nichols D E; Sit S Y; Taber M T
Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2001;296(2):338-44.
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2001: Huang X; Lawler C P; Lewis M M; Nichols D E; Mailman R B
D1 dopamine receptors.
International review of neurobiology 2001;48():65-139.
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1999: Montague D M; Lawler C P; Mailman R B; Gilmore J H
Developmental regulation of the dopamine D1 receptor in human caudate and putamen.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(5):641-9.
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1999: Hoffman B; Cho S J; Zheng W; Wyrick S; Nichols D E; Mailman R B; Tropsha A
Quantitative structure-activity relationship modeling of dopamine D(1) antagonists using comparative molecular field analysis, genetic algorithms-partial least-squares, and K nearest neighbor methods.
Journal of medicinal chemistry 1999;42(17):3217-26.
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1999: Lawler C P; Prioleau C; Lewis M M; Mak C; Jiang D; Schetz J A; Gonzalez A M; Sibley D R; Mailman R B
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(6):612-27.
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1999: Doll M K; Nichols D E; Kilts J D; Prioleau C; Lawler C P; Lewis M M; Mailman R B
Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.
Journal of medicinal chemistry 1999;42(5):935-40.
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1998: Lieberman J A; Mailman R B; Duncan G; Sikich L; Chakos M; Nichols D E; Kraus J E
Serotonergic basis of antipsychotic drug effects in schizophrenia.
Biological psychiatry 1998;44(11):1099-117.
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1998: Duncan G E; Leipzig J N; Mailman R B; Lieberman J A
Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation.
Brain research 1998;812(1-2):65-75.
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1998: Smith D R; Striplin C D; Geller A M; Mailman R B; Drago J; Lawler C P; Gallagher M
Behavioural assessment of mice lacking D1A dopamine receptors.
Neuroscience 1998;86(1):135-46.
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1998: Mailman R B; Nichols D E
Dopamine D1 receptor agonists as antiparkinson drugs.
Trends in pharmacological sciences 1998;19(7):255-6.
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1998: Lewis M M; Watts V J; Lawler C P; Nichols D E; Mailman R B
Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
The Journal of pharmacology and experimental therapeutics 1998;286(1):345-53.
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1998: Monte A P; Marona-Lewicka D; Lewis M M; Mailman R B; Wainscott D B; Nelson D L; Nichols D E
Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity.
Journal of medicinal chemistry 1998;41(12):2134-45.
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1998: Andersson C; Chakos M; Mailman R; Lieberman J
Emerging roles for novel antipsychotic medications in the treatment of schizophrenia.
The Psychiatric clinics of North America 1998;21(1):151-79.
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1998: Bunin M A; Prioleau C; Mailman R B; Wightman R M
Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain.
Journal of neurochemistry 1998;70(3):1077-87.
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1997: Negash K; Nichols D E; Watts V J; Mailman R B
Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine.
Journal of medicinal chemistry 1997;40(14):2140-7.
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1997: Smith H P; Nichols D E; Mailman R B; Lawler C P
Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist.
European journal of pharmacology 1997;323(1):27-36.
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1996: Walker Q D; Mailman R B
Triadimefon and triadimenol: effects on monoamine uptake and release.
Toxicology and applied pharmacology 1996;139(2):227-33.
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1996: Mottola D M; Laiter S; Watts V J; Tropsha A; Wyrick S D; Nichols D E; Mailman R B
Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping.
Journal of medicinal chemistry 1996;39(1):285-96.
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1996: Ghosh D; Snyder S E; Watts V J; Mailman R B; Nichols D E
9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.
Journal of medicinal chemistry 1996;39(2):549-55.
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1995: Lawler C P; Gilmore J H; Watts V J; Walker Q D; Southerland S B; Cook L L; Mathis C A; Mailman R B
Interhemispheric modulation of dopamine receptor interactions in unilateral 6-OHDA rodent model.
Synapse (New York, N.Y.) 1995;21(4):299-311.
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1995: Watts V J; Lawler C P; Gonzales A J; Zhou Q Y; Civelli O; Nichols D E; Mailman R B
Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists.
Synapse (New York, N.Y.) 1995;21(2):177-87.
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1995: Wyrick S D; Booth R G; Myers A M; Owens C E; Bucholtz E C; Hooper P C; Kula N S; Baldessarini R J; Mailman R B
1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and related derivatives as ligands for the neuromodulatory sigma 3 receptor: further structure-activity relationships.
Journal of medicinal chemistry 1995;38(19):3857-64.
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1995: Gariépy J L; Gendreau P L; Mailman R B; Tancer M; Lewis M H
Rearing conditions alter social reactivity and D1 dopamine receptors in high- and low-aggressive mice.
Pharmacology, biochemistry, and behavior 1995;51(4):767-73.
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1995: Knoerzer T A; Watts V J; Nichols D E; Mailman R B
Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors.
Journal of medicinal chemistry 1995;38(16):3062-70.
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1995: Snyder S E; Aviles-Garay F A; Chakraborti R; Nichols D E; Watts V J; Mailman R B
Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of beta-phenyldopamine.
Journal of medicinal chemistry 1995;38(13):2395-409.
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1995: Gilmore J H; Watts V J; Lawler C P; Noll E P; Nichols D E; Mailman R B
"Full" dopamine D1 agonists in human caudate: biochemical properties and therapeutic implications.
Neuropharmacology 1995;34(5):481-8.
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1995: Watts V J; Lawler C P; Fox D R; Neve K A; Nichols D E; Mailman R B
LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors.
Psychopharmacology 1995;118(4):401-9.
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1995: Brewster W K; Nichols D E; Watts V J; Riggs R M; Mottola D; Mailman R B
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.
Journal of medicinal chemistry 1995;38(2):318-27.
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1994: Minor D L; Wyrick S D; Charifson P S; Watts V J; Nichols D E; Mailman R B
Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.
Journal of medicinal chemistry 1994;37(25):4317-28.
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1994: Knoerzer T A; Nichols D E; Brewster W K; Watts V J; Mottola D; Mailman R B
Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist.
Journal of medicinal chemistry 1994;37(15):2453-60.
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1994: Lewis M H; Gariépy J L; Gendreau P; Nichols D E; Mailman R B
Social reactivity and D1 dopamine receptors: studies in mice selectively bred for high and low levels of aggression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;10(2):115-22.
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1994: Tancer M E; Mailman R B; Stein M B; Mason G A; Carson S W; Golden R N
Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia.
Anxiety 1994;1(5):216-23.
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1993: Booth R G; Wyrick S D; Baldessarini R J; Kula N S; Myers A M; Mailman R B
New sigma-like receptor recognized by novel phenylaminotetralins: ligand binding and functional studies.
Molecular pharmacology 1993;44(6):1232-9.
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1993: Watts V J; Lawler C P; Gilmore J H; Southerland S B; Nichols D E; Mailman R B
Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents.
European journal of pharmacology 1993;242(2):165-72.
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1993: Lawler C P; Gilmore J H; Mooney D H; Mayleben M A; Atashi J R; Mileson B E; Wyrick S D; Mailman R B
A rapid and efficient method for the radiosynthesis and purification of [125I]SCH23982.
Journal of neuroscience methods 1993;49(1-2):141-53.
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1993: Watts V J; Lawler C P; Knoerzer T; Mayleben M A; Neve K A; Nichols D E; Mailman R B
Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands.
European journal of pharmacology 1993;239(1-3):271-3.
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1993: Wyrick S D; Booth R G; Myers A M; Owens C E; Kula N S; Baldessarini R J; McPhail A T; Mailman R B
Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity.
Journal of medicinal chemistry 1993;36(17):2542-51.
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1993: Gilmore J H; Lawler C P; Eaton A M; Mailman R B
Postmortem stability of dopamine D1 receptor mRNA and D1 receptors.
Brain research. Molecular brain research 1993;18(4):290-6.
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1992: Mottola D M; Brewster W K; Cook L L; Nichols D E; Mailman R B
Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist.
The Journal of pharmacology and experimental therapeutics 1992;262(1):383-93.
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1991: Lovenberg T W; Roth R H; Nichols D E; Mailman R B
D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors.
Journal of neurochemistry 1991;57(5):1563-9.
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1991: Darney K J; Lewis M H; Brewster W K; Nichols D E; Mailman R B
Behavioral effects in the rat of dihydrexidine, a high-potency, full-efficacy D1 dopamine receptor agonist.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;5(3):187-95.
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1991: Mileson B E; Lewis M H; Mailman R B
Dopamine receptor 'supersensitivity' occurring without receptor up-regulation.
Brain research 1991;561(1):1-10.
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1991: Lovenberg T W; Nichols D E; Nestler E J; Roth R H; Mailman R B
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Brain research 1991;556(1):101-7.
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1990: Brewster W K; Nichols D E; Riggs R M; Mottola D M; Lovenberg T W; Lewis M H; Mailman R B
trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.
Journal of medicinal chemistry 1990;33(6):1756-64.
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1990: Lewis M H; Gluck J P; Beauchamp A J; Keresztury M F; Mailman R B
Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge.
Brain research 1990;513(1):67-73.
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1990: Walker Q D; Lewis M H; Crofton K M; Mailman R B
Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats.
Toxicology and applied pharmacology 1990;102(3):474-85.
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1989: Charifson P S; Bowen J P; Wyrick S D; Hoffman A J; Cory M; McPhail A T; Mailman R B
Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
Journal of medicinal chemistry 1989;32(9):2050-8.
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1989: Niedzwiecki D M; Cubeddu L X; Mailman R B
Comparative anticholinergic properties of thioridazine, mesoridazine and sulforidazine.
The Journal of pharmacology and experimental therapeutics 1989;250(1):126-33.
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1989: Niedzwiecki D M; Cubeddu L X; Mailman R B
Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum.
The Journal of pharmacology and experimental therapeutics 1989;250(1):117-25.
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1989: Lovenberg T W; Brewster W K; Mottola D M; Lee R C; Riggs R M; Nichols D E; Lewis M H; Mailman R B
Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist.
European journal of pharmacology 1989;166(1):111-3.
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1988: Charifson P S; Wyrick S D; Hoffman A J; Simmons R M; Bowen J P; McDougald D L; Mailman R B
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.
Journal of medicinal chemistry 1988;31(10):1941-6.
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1988: DeHaven-Hudkins D L; Schulz D W; Walsh T J; Mailman R B
Responses of dopaminergic and serotonergic systems to triethyllead intoxication.
Neurotoxicology and teratology 1988;10(4):279-85.
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1987: Mailman R B
Mechanisms of CNS injury in behavioral dysfunction.
Neurotoxicology and teratology 1987;9(6):417-26.
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