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Philip De Jager

Research Profile

Disorders

Physiology

Genes & Molecular Sequences

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Purkinje Cells

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Linda Ottoboni; Pablo Tamayo; Howard L Weiner; Guy J Buckle; David A Hafler; Brendan T Keenan; Samia J Khoury; Manik Kuchroo; Jill P Mesirov; Philip De Jager
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
Zongqi Xia; Christoph Berger; Irene Wood Castillo; Patrick C Cheney; Philip De Jager; Anna Kaliszewska; Brendan T Keenan; Qingquan Liu; Gyan P Srivastava; Galit Alter
A 17q12 allele is associated with altered NK cell subsets and function.
Robert Gross; Brian C Healy; Sabine Cepok; Tanuja Chitnis; Samia J Khoury; Bernard Hemmer; Howard L Weiner; David A Hafler; Philip De Jager
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.

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All Publications

2012: Linda Ottoboni; Pablo Tamayo; Howard L Weiner; Guy J Buckle; David A Hafler; Brendan T Keenan; Samia J Khoury; Manik Kuchroo; Jill P Mesirov; Philip De Jager
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
Science translational medicine 2012;4(153):153ra131.
2012: Zongqi Xia; Christoph Berger; Irene Wood Castillo; Patrick C Cheney; Philip De Jager; Anna Kaliszewska; Brendan T Keenan; Qingquan Liu; Gyan P Srivastava; Galit Alter
A 17q12 allele is associated with altered NK cell subsets and function.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):3315-22.
2011: Robert Gross; Brian C Healy; Sabine Cepok; Tanuja Chitnis; Samia J Khoury; Bernard Hemmer; Howard L Weiner; David A Hafler; Philip De Jager
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.
Journal of neuroimmunology 2011;233(1-2):168-74.
2011: Lori B Chibnik; Joshua M Shulman; Sue E Leurgans; Julie A Schneider; Robert S Wilson; Dong Tran; Cristin Aubin; Aron S Buchman; Christopher B Heward; Amanda Myers; John Hardy; Matthew Huentelman; Jason J Corneveaux; Eric Reiman; Denis A Evans; David A Bennett; Philip De Jager
CR1 is associated with amyloid plaque burden and age-related cognitive decline.
Annals of neurology 2011;69(3):560-9.
2011: Amanda A Fox; David A Hafler; Daniel S Herman; Kuang-Yu Liu; Jochen Muehlschlegel; Tjorvi E Perry; Mias Pretorius; Dan M Roden; Simon Body; Charles Collard; Dawood Darbar; Philip De Jager; Steven R Depalma; Brian S Donahue; Jonathan G Seidman; Stanton K Shernan; Christine E Seidman
Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.
PloS one 2011;6(9):e24593.
2011: Joanne H Wang; Derek Pappas; Daniel Pelletier; Chris H Polman; Sergio E Baranzini; Lori B Chibnik; Paul Iw de Bakker; Philip De Jager; David A Hafler; Stephen L Hauser; Ludwig Kappos; Paul M Matthews; Jorge R Oksenberg
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.
Genome medicine 2011;3(1):3.
2010: B C Healy; Maria Liguori; D Tran; Tanuja Chitnis; B Glanz; C Wolfish; S Gauthier; Guy J Buckle; M Houtchens; L Stazzone; S Khoury; R Hartzmann; M Fernandez-Vina; David A Hafler; Howard L Weiner; Charles R G Guttmann; Philip De Jager
HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Neurology 2010;75(7):634-40.
2010: Joshua M Shulman; Lori B Chibnik; Cristin Aubin; Julie A Schneider; David A Bennett; Philip De Jager
Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
PloS one 2010;5(6):e11244.
2009: Philip De Jager; Lori B Chibnik; Jing Cui; Joachim Reischl; Stephan Lehr; K Claire Simon; Cristin Aubin; David Bauer; Jürgen F Heubach; Rupert Sandbrink; Michaela Tyblova; Petra Lelkova; Eva Havrdova; Christoph Pohl; Dana Horakova; Alberto Ascherio; David A Hafler; Elizabeth W Karlson
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
Lancet neurology 2009;8(12):1111-9.
2009: Philip De Jager
Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the future.
Therapeutic advances in neurological disorders 2009;2(6):8-19.
2009: Steven C Greenway; Alexandre C Pereira; Jennifer C Lin; Steven R Depalma; Samuel J Israel; Sonia M Mesquita; Emel Ergul; Jessie H Conta; Joshua M Korn; Steven A McCarroll; Joshua M Gorham; Stacey Gabriel; David Altshuler; Maria de Lourdes Quintanilla-Dieck; Maria Alexandra Artunduaga; Roland D Eavey; Robert M Plenge; Nancy A Shadick; Michael E Weinblatt; Philip De Jager; David A Hafler; Roger E Breitbart; Jonathan G Seidman; Christine E Seidman
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
Nature genetics 2009;41(8):931-5.
2009: Lisa M Maier; David E Anderson; Christopher A Severson; Clare Baecher-Allan; Brian Healy; David V Liu; K Dane Wittrup; Philip De Jager; David A Hafler
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1541-7.
2009: Lisa M Maier; Christopher E Lowe; Jason Cooper; Kate Downes; David E Anderson; Christopher Severson; Pamela M Clark; Brian Healy; Neil Walker; Cristin Aubin; Jorge R Oksenberg; Stephen L Hauser; Alistair Compston; Stephen Sawcer; Philip De Jager; Linda S Wicker; John A Todd; David A Hafler
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2008: Edwin Choy; Roman Yelensky; Sasha Bonakdar; Robert M Plenge; Richa Saxena; Philip De Jager; Stanley Y Shaw; Cara S Wolfish; Jacqueline M Slavik; Chris Cotsapas; Manuel Rivas; Emmanouil T Dermitzakis; Ellen Cahir-McFarland; Elliott Kieff; David Hafler; Mark J Daly; David Altshuler
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
PLoS genetics 2008;4(11):e1000287.
2008: Philip De Jager; Elizabeth Rossin; Saumyadipta Pyne; Pablo Tamayo; Linda Ottoboni; Vissia Viglietta; Mira Weiner; Dulce Soler; Elena Izmailova; Lauren Faron-Yowe; Carmeline O'Brien; Sam Freeman; Susana Granados; Alex Parker; Ronenn Roubenoff; Jill P Mesirov; Samia J Khoury; David A Hafler; Howard L Weiner
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells.
Brain : a journal of neurology 2008;131(Pt 7):1701-11.
2008: Benjamin Rhodes; David L Morris; Lakshman Subrahmanyan; Cristin Aubin; Carlos F Mendes De Leon; Jeremiah F Kelly; Dennis A Evans; John C Whittaker; Jorge R Oksenberg; Philip De Jager; Timothy J Vyse
Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
Human genetics 2008;123(6):633-42.
2008: Michelle M A Fernando; Christine R Stevens; Emily C Walsh; Philip De Jager; Philippe Goyette; Robert M Plenge; Timothy J Vyse; John D Rioux
Defining the role of the MHC in autoimmunity: a review and pooled analysis.
PLoS genetics 2008;4(4):e1000024.
2008: Philip De Jager; K C Simon; K L Munger; John D Rioux; David A Hafler; A Ascherio
Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.
Neurology 2008;70(13 Pt 2):1113-8.
2007: Lisa M Maier; David E Anderson; Philip De Jager; Linda S Wicker; David A Hafler
Allelic variant in CTLA4 alters T cell phosphorylation patterns.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18607-12.
2007: David A Hafler; Alastair Compston; Stephen Sawcer; Eric S Lander; Mark J Daly; Philip De Jager; Paul I W de Bakker; Stacey B Gabriel; Daniel B Mirel; Adrian J Ivinson; Margaret Pericak-Vance; Simon G Gregory; John D Rioux; Jacob McCauley; Jonathan L Haines; Lisa F Barcellos; Bruce A C Cree; Jorge R Oksenberg; Stephen L Hauser
Risk alleles for multiple sclerosis identified by a genomewide study.
The New England journal of medicine 2007;357(9):851-62.
2007: Philip De Jager; Denis Franchimont; Alicja Waliszewska; Alain Bitton; Albert Cohen; Diane Langelier; J Belaiche; Severine Vermeire; Lisa Farwell; An Goris; Cecile Libioulle; NIRAJ JANI; Themistocles Dassopoulos; Gillian P Bromfield; Bruno Dubois; J H Cho; Steven R Brant; Richard H Duerr; Haifeng Yang; J I Rotter; M S Silverberg; A Hillary Steinhart; Mark J Daly; Daniel K Podolsky; E Louis; David A Hafler; John D Rioux
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.
Genes and immunity 2007;8(5):387-97.
2007: David Reich; Nick Patterson; Vijaya Ramesh; Philip De Jager; Gavin J McDonald; Arti Tandon; Edwin Choy; Donglei Hu; Bani Tamraz; Ludmila Pawlikowska; Christina Wassel Fyr; Scott Huntsman; Alicja Waliszewska; Elizabeth Rossin; Rongling Li; Melissa Garcia; Alexander Reiner; Robert Ferrell; Steve Cummings; Pui-Yan Kwok; Tamara Harris; Joseph Zmuda; Elad Ziv
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
American journal of human genetics 2007;80(4):716-26.
2007: Tai Wai Yeo; Philip De Jager; Simon G Gregory; Lisa F Barcellos; Amie Walton; An Goris; Chiara Fenoglio; Maria Ban; Craig J Taylor; Reyna S Goodman; Emily Walsh; Cara S Wolfish; Roger HORTON; James A Traherne; Stephan Beck; John Trowsdale; Stacy J Caillier; Adrian J Ivinson; Todd Green; Susan Pobywajlo; Eric S Lander; Margaret Pericak-Vance; Jonathan L Haines; Mark J Daly; Jorge R Oksenberg; Stephen L Hauser; Alastair Compston; David A Hafler; John D Rioux; Stephen Sawcer
A second major histocompatibility complex susceptibility locus for multiple sclerosis.
Annals of neurology 2007;61(3):228-36.
2007: Kevin C O'Connor; Katherine McLaughlin; Philip De Jager; Tanuja Chitnis; Estelle Bettelli; Chenqi Xu; William H Robinson; Sunil V Cherry; Amit Bar-Or; Brenda L Banwell; Hikoaki Fukaura; Toshiyuki Fukazawa; Silvia Tenembaum; Susan J Wong; Norma P Tavakoli; Zhannat Idrissova; Vissia Viglietta; Kevin Rostasy; Daniela Pohl; Russell C Dale; Mark Freedman; Lawrence Steinman; Guy J Buckle; Vijay K Kuchroo; David A Hafler; Kai W Wucherpfennig
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
Nature medicine 2007;13(2):211-7.
2007: Philip De Jager; David A Hafler
New therapeutic approaches for multiple sclerosis.
Annual review of medicine 2007;58():417-32.
2006: Philip De Jager; R Graham; Lisa Farwell; Stephen Sawcer; A Richardson; timothy wayne behrens; Alastair Compston; David A Hafler; Juha Kere; Timothy J Vyse; John D Rioux
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.
Genes and immunity 2006;7(4):327-34.
2006: Philip De Jager; Angela Richardson; Timothy J Vyse; John D Rioux
Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus.
Arthritis and rheumatism 2006;54(4):1279-82.
2006: Philip De Jager; Stephen Sawcer; Alicja Waliszewska; Lisa Farwell; Gary Wild; Albert Cohen; Diane Langelier; Alain Bitton; Alastair Compston; David A Hafler; John D Rioux
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
European journal of human genetics : EJHG 2006;14(3):317-21.
2005: David Reich; Nick Patterson; Philip De Jager; Gavin J McDonald; Alicja Waliszewska; Arti Tandon; Robin R Lincoln; Cari DeLoa; Scott A Fruhan; Philippe Cabre; Odile Bera; Gilbert Semana; M Ann Kelly; David A Francis; Kristin G Ardlie; OA Khan; Bruce A C Cree; Stephen L Hauser; Jorge R Oksenberg; David A Hafler
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Nature genetics 2005;37(10):1113-8.
2005: Stephen Sawcer; Maria Ban; Mel Maranian; Tai Wai Yeo; Alastair Compston; Andrew Kirby; Mark J Daly; Philip De Jager; Emily Walsh; Eric S Lander; John D Rioux; David A Hafler; Adrian Ivinson; Jacqueline Rimmler; Simon G Gregory; Silke Schmidt; Margaret Pericak-Vance; Eva Akesson; Jan Hillert; Pameli Datta; Annette Oturai; lars peter ryder; Hanne F Harbo; Anne Spurkland; Kjell-Morten Myhr; Mikko Laaksonen; David Booth; Robert Heard; Graeme Stewart; Robin Lincoln; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
A high-density screen for linkage in multiple sclerosis.
American journal of human genetics 2005;77(3):454-67.
2005: David A Hafler; Philip De Jager
Applying a new generation of genetic maps to understand human inflammatory disease.
Nature reviews. Immunology 2005;5(1):83-91.
2004: Stephen Sawcer; Mel Maranian; Sara Singlehurst; Taiwai Yeo; Alastair Compston; Mark J Daly; Philip De Jager; Stacey Gabriel; David A Hafler; Adrian J Ivinson; Eric S Lander; John D Rioux; Emily Walsh; Simon G Gregory; Silke Schmidt; Margaret Pericak-Vance; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.
Human molecular genetics 2004;13(17):1943-9.
2004: Philip De Jager; Emily C Walsh; John D Rioux; David A Hafler
Re: GAMES issue study: Are international genetic consortia functional?
Journal of neuroimmunology 2004;153(1-2):5-6.
2004: Philip De Jager; David A Hafler
Gene expression profiling in MS: what is the clinical relevance?
Lancet neurology 2004;3(5):269.
2004: Michael W Smith; Nick Patterson; James A Lautenberger; Ann L Truelove; Gavin J McDonald; Alicja Waliszewska; Bailey D Kessing; Michael J Malasky; Charles Scafe; Ernest Le; Philip De Jager; Andre A Mignault; Zeng Yi; Guy De The; Myron Essex; Jean-louis Sankale; Jason Moore; Kwabena Poku; John P Phair; James J Goedert; David Vlahov; scott williams; Sarah A Tishkoff; Cheryl A Winkler; Francisco M De La Vega; Trevor Woodage; John J Sninsky; David A Hafler; David Altshuler; Dennis A Gilbert; Stephen J O'Brien; David Reich
A high-density admixture map for disease gene discovery in african americans.
American journal of human genetics 2004;74(5):1001-13.
2000: Martin L Doughty; Philip De Jager; S J Korsmeyer; Nathaniel Heintz
Neurodegeneration in Lurcher mice occurs via multiple cell death pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3687-94.
1999: Nathaniel Heintz; Philip De Jager
GluR delta 2 and the development and death of cerebellar Purkinje neurons in lurcher mice.
Annals of the New York Academy of Sciences 1999;868():502-14.
1998: Philip De Jager; Nathaniel Heintz
The lurcher mutation and ionotropic glutamate receptors: contributions to programmed neuronal death in vivo.
Brain pathology (Zurich, Switzerland) 1998;8(4):795-807.
1998: Philip De Jager; D Harvey; AD Polydorides; Jianru Zuo; Nathaniel Heintz
A high-resolution genetic map of the nervous locus on mouse chromosome 8.
Genomics 1998;48(3):346-53.
1998: W Hu; Jianru Zuo; Philip De Jager; Nathaniel Heintz
The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22.
Genomics 1998;47(1):143-5.
1997: Philip De Jager; Jianru Zuo; S A Cook; Nathaniel Heintz
A new allele of the lurcher gene, lurcherJ.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(9):647-50.
1997: Jianru Zuo; Philip De Jager; K A Takahashi; W Jiang; David J Linden; Nathaniel Heintz
Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene.
Nature 1997;388(6644):769-73.
1997: Philip De Jager; Jianru Zuo; Nathaniel Heintz
An approximately 1.2-Mb bacterial artificial chromosome contig refines the genetic and physical maps of the lurcher locus on mouse chromosome 6.
Genome research 1997;7(7):736-46.
1995: Jianru Zuo; Philip De Jager; D J Norman; Nathaniel Heintz
Generation of a high-resolution genetic map and a YAC contig of the Lurcher locus on mouse chromosome 6.
Genome research 1995;5(4):381-92.