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P Burn

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Gertjan van Dijk; Randy J Seeley; Todd E Thiele; M I Friedman; H Ji; Charles William Wilkinson; P Burn; L Arthur Campfield; R Tenenbaum; Denis Baskin; Stephen C Woods; Michael W Schwartz
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat.
Mary M Hagan; Paul Rushing; Michael W Schwartz; Keith Yagaloff; P Burn; Stephen C Woods; Randy J Seeley
Role of the CNS melanocortin system in the response to overfeeding.
DL Nagle; S H McGrail; J Vitale; EA Woolf; BJ Dussault; L DiRocco; LM Holmgren; Jill Montagno; P Bork; Dennis Huszar; Victoria Fairchild-Huntress; P Ge; JJ Keilty; C Ebeling; L Baldini; J Gilchrist; P Burn; GA Carlson; KJ Moore
The mahogany protein is a receptor involved in suppression of obesity.

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1999: Gertjan van Dijk; Randy J Seeley; Todd E Thiele; M I Friedman; H Ji; Charles William Wilkinson; P Burn; L Arthur Campfield; R Tenenbaum; Denis Baskin; Stephen C Woods; Michael W Schwartz
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat.
The American journal of physiology 1999;276(5 Pt 2):R1425-33.
1999: Mary M Hagan; Paul Rushing; Michael W Schwartz; Keith Yagaloff; P Burn; Stephen C Woods; Randy J Seeley
Role of the CNS melanocortin system in the response to overfeeding.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):2362-7.
1999: DL Nagle; S H McGrail; J Vitale; EA Woolf; BJ Dussault; L DiRocco; LM Holmgren; Jill Montagno; P Bork; Dennis Huszar; Victoria Fairchild-Huntress; P Ge; JJ Keilty; C Ebeling; L Baldini; J Gilchrist; P Burn; GA Carlson; KJ Moore
The mahogany protein is a receptor involved in suppression of obesity.
Nature 1999;398(6723):148-52.
1999: W Gu; Z Tu; P W Kleyn; A Kissebah; LJ Duprat; J Lee; W Chin; S Maruti; N Deng; SL Fisher; L S Franco; P Burn; Keith Yagaloff; J Nathan; S Heymsfield; Jeanine B Albu; F X Pi-Sunyer; David Allison
Identification and functional analysis of novel human melanocortin-4 receptor variants.
Diabetes 1999;48(3):635-9.
1999: Denis Baskin; Michael W Schwartz; Randy J Seeley; Stephen C Woods; Daniel Porte; John Breininger; Z Jonak; J Schaefer; M Krouse; C Burghardt; L Arthur Campfield; P Burn; JP Kochan
Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(3):353-62.
1999: SL Fisher; Keith Yagaloff; P Burn
Melanocortin-4 receptor: a novel signalling pathway involved in body weight regulation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23 Suppl 1():54-8.
1999: S C Chen; JP Kochan; L Arthur Campfield; P Burn; R J Smeyne
Splice variants of the OB receptor gene are differentially expressed in brain and peripheral tissues of mice.
Journal of receptor and signal transduction research 1999;19(1-4):245-66.
1999: SL Fisher; Keith Yagaloff; P Burn
Melanocortin and leptin signaling systems: central regulation of catabolic energy balance.
Journal of receptor and signal transduction research 1999;19(1-4):203-16.
1999: DJ Marsh; G Hollopeter; Dennis Huszar; R Laufer; Keith Yagaloff; SL Fisher; P Burn; Richard D Palmiter
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.
Nature genetics 1999;21(1):119-22.
1998: FJ Smith; L Arthur Campfield; J A Moschera; P S Bailon; P Burn
Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice.
Regulatory peptides 1998;75-76():433-9.
1998: L Arthur Campfield; FJ Smith; P Burn
Strategies and potential molecular targets for obesity treatment.
Science (New York, N.Y.) 1998;280(5368):1383-7.
1998: Kurt Amrein; J Molnos; J D zur Hausen; N Flint; B Takacs; P Burn
Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation.
Farmaco (Società chimica italiana : 1989) 1998;53(4):266-72.
1998: Joseph F Grippo; P Burn
Obesity genes: molecular genetic approaches to drug target identification.
Farmaco (Società chimica italiana : 1989) 1998;53(4):262-5.
1998: Y Guisez; I Faché; L Arthur Campfield; FJ Smith; A Farid; G Plaetinck; José Van der Heyden; Jan Tavernier; W Fiers; P Burn; R Devos
Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.
Protein expression and purification 1998;12(2):249-58.
1998: Todd E Thiele; Gertjan van Dijk; Keith Yagaloff; SL Fisher; M Schwartz; P Burn; Randy J Seeley
Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion.
The American journal of physiology 1998;274(1 Pt 2):R248-54.
1997: Michael W Schwartz; Randy J Seeley; Stephen C Woods; David S Weigle; L Arthur Campfield; P Burn; Denis Baskin
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.
Diabetes 1997;46(12):2119-23.
1997: Randy J Seeley; Keith Yagaloff; SL Fisher; P Burn; Todd E Thiele; Gertjan van Dijk; Denis Baskin; Michael W Schwartz
Melanocortin receptors in leptin effects.
Nature 1997;390(6658):349.
1997: Gertjan van Dijk; J C Donahey; Todd E Thiele; Anton J W Scheurink; AB Steffens; Charles William Wilkinson; R Tenenbaum; L Arthur Campfield; P Burn; Randy J Seeley; Stephen C Woods
Central leptin stimulates corticosterone secretion at the onset of the dark phase.
Diabetes 1997;46(11):1911-4.
1997: J D zur Hausen; P Burn; Kurt Amrein
Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms.
European journal of immunology 1997;27(10):2643-9.
1997: Hui Chen; S J Wertheimer; CH Lin; S L Katz; Kurt Amrein; P Burn; Michael Quon
Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.
The Journal of biological chemistry 1997;272(12):8026-31.
1997: Todd E Thiele; Gertjan van Dijk; L Arthur Campfield; FJ Smith; P Burn; Stephen C Woods; Ilene L Bernstein; Randy J Seeley
Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats.
The American journal of physiology 1997;272(2 Pt 2):R726-30.
1997: Dennis Huszar; CA Lynch; Victoria Fairchild-Huntress; Judy H Dunmore; Q Fang; L R Berkemeier; W Gu; RA Kesterson; Bruce Alan Boston; Roger D Cone; FJ Smith; L Arthur Campfield; P Burn; F Lee
Targeted disruption of the melanocortin-4 receptor results in obesity in mice.
Cell 1997;88(1):131-41.
1997: L Arthur Campfield; FJ Smith; L Pénicaud; P Burn
[OB protein and its receptor: signal transduction between adipose tissue and central nervous system].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1997;():131-48.
1996: Randy J Seeley; Gertjan van Dijk; L Arthur Campfield; F J Smith; P Burn; J A Nelligan; S M Bell; Denis Baskin; Stephen C Woods; Michael W Schwartz
Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):664-8.
1996: L Arthur Campfield; F J Smith; P Burn
The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):619-32.
1996: M A Osborne; G Zenner; M Lubinus; X Zhang; Zhou Songyang; L C Cantley; P Majerus; P Burn; JP Kochan
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
The Journal of biological chemistry 1996;271(46):29271-8.
1996: Steven D Hartson; D J Barrett; P Burn; Robert L Matts
Hsp90-mediated folding of the lymphoid cell kinase p56lck.
Biochemistry 1996;35(41):13451-9.
1996: Gertjan van Dijk; Todd E Thiele; J C Donahey; L Arthur Campfield; F J Smith; P Burn; Ilene L Bernstein; Stephen C Woods; Randy J Seeley
Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain.
The American journal of physiology 1996;271(4 Pt 2):R1096-100.
1996: G Zenner; T Vorherr; Tomas Mustelin; P Burn
Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain.
Journal of cellular biochemistry 1996;63(1):94-103.
1996: Michael W Schwartz; Randy J Seeley; L Arthur Campfield; P Burn; Denis Baskin
Identification of targets of leptin action in rat hypothalamus.
The Journal of clinical investigation 1996;98(5):1101-6.
1996: L Arthur Campfield; FJ Smith; Y Guisez; R Devos; P Burn
OB protein: A peripheral signal linking adiposity and central neural networks.
Appetite 1996;26(3):302.
1996: R Devos; J G Richards; L Arthur Campfield; Louis A Tartaglia; Y Guisez; José Van der Heyden; J Travernier; G Plaetinck; P Burn
OB protein binds specifically to the choroid plexus of mice and rats.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5668-73.
1995: G Zenner; J Dirk zur Hausen; P Burn; Tomas Mustelin
Towards unraveling the complexity of T cell signal transduction.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(11):967-75.
1995: Philip A Cole; M R Grace; Robert S Phillips; P Burn; Christopher T Walsh
The role of the catalytic base in the protein tyrosine kinase Csk.
The Journal of biological chemistry 1995;270(38):22105-8.
1995: L Arthur Campfield; FJ Smith; Y Guisez; R Devos; P Burn
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.
Science (New York, N.Y.) 1995;269(5223):546-9.
1995: Tomas Mustelin; Scott Williams; Pankaj Tailor; Clément Couture; G Zenner; P Burn; J D Ashwell; Amnon Altman
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.
European journal of immunology 1995;25(4):942-6.
1995: Kurt Amrein; B Takacs; M Stieger; J Molnos; N A Flint; P Burn
Purification and characterization of recombinant human p50csk protein-tyrosine kinase from an Escherichia coli expression system overproducing the bacterial chaperones GroES and GroEL.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1048-52.
1994: Philip A Cole; P Burn; B Takacs; Christopher T Walsh
Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects.
The Journal of biological chemistry 1994;269(49):30880-7.
1994: Clément Couture; Gottfried Baier; C Oetken; Scott Williams; D Telford; A Marie-Cardine; Gabriele Baier-Bitterlich; S Fischer; P Burn; Amnon Altman
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.
Molecular and cellular biology 1994;14(8):5249-58.
1994: Kurt Amrein; B Panholzer; J Molnos; N A Flint; J Scheffler; H W Lahm; W Bannwarth; P Burn
Mapping of the p56lck-mediated phosphorylation of GAP and analysis of its influence on p21ras-GTPase activity in vitro.
Biochimica et biophysica acta 1994;1222(3):441-6.
1994: P Caspers; M Stieger; P Burn
Overproduction of bacterial chaperones improves the solubility of recombinant protein tyrosine kinases in Escherichia coli.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(5):635-44.
1994: N A Flint; Kurt Amrein; T Jascur; P Burn
Purification and characterization of an activated form of the protein tyrosine kinase Lck from an Escherichia coli expression system.
Journal of cellular biochemistry 1994;55(3):389-97.
1994: Erich Gulbins; K Mark Coggeshall; Gottfried Baier; D Telford; C Langlet; Gabriele Baier-Bitterlich; N Bonnefoy-Berard; P Burn; A Wittinghofer; Amnon Altman
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.
Molecular and cellular biology 1994;14(7):4749-58.
1994: C Oetken; Clément Couture; M Bergman; N Bonnefoy-Bérard; Scott Williams; Kari Alitalo; P Burn; Tomas Mustelin
TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain.
Oncogene 1994;9(6):1625-31.
1994: Erich Gulbins; K Mark Coggeshall; C Langlet; Gottfried Baier; N Bonnefoy-Berard; P Burn; A Wittinghofer; S Katzav; Amnon Altman
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.
Molecular and cellular biology 1994;14(2):906-13.
1994: M Autero; Juha Saharinen; Tiina Pessa-Morikawa; M Soula-Rothhut; C Oetken; M Gassmann; M Bergman; Kari Alitalo; P Burn; Carl G Gahmberg
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Molecular and cellular biology 1994;14(2):1308-21.
1994: M von Willebrand; Gottfried Baier; Clément Couture; P Burn; Tomas Mustelin
Activation of phosphatidylinositol-3-kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase.
European journal of immunology 1994;24(1):234-8.
1994: M Gassmann; Kurt Amrein; N A Flint; B Schraven; P Burn
Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes.
European journal of immunology 1994;24(1):139-44.
1993: Kurt Amrein; B Panholzer; N A Flint; W Bannwarth; P Burn
The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10285-9.
1993: Tomas Mustelin; P Burn
Regulation of src family tyrosine kinases in lymphocytes.
Trends in biochemical sciences 1993;18(6):215-20.
1993: Erich Gulbins; K Mark Coggeshall; Gottfried Baier; S Katzav; P Burn; Amnon Altman
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
Science (New York, N.Y.) 1993;260(5109):822-5.
1993: M Stieger; N A Flint; H Jacot-Guillermod; P Burn
Mouse monoclonal antibodies that specifically recognize an amino-terminal epitope of p56lck protein tyrosine kinase.
FEBS letters 1993;321(1):41-5.
1993: M Gassmann; Kurt Amrein; P Burn
CD4:p56lck association studied in vivo using antibody-induced capping and double indirect immunofluorescence microscopy.
Journal of receptor research 1993;13(1-4):711-24.
1992: M Guttinger; M Gassmann; Kurt Amrein; P Burn
CD45 phosphotyrosine phosphatase and p56lck protein tyrosine kinase: a functional complex crucial in T cell signal transduction.
International immunology 1992;4(11):1325-30.
1992: M Bergman; Tomas Mustelin; C Oetken; J Partanen; N A Flint; Kurt Amrein; M Autero; P Burn; Kari Alitalo
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
The EMBO journal 1992;11(8):2919-24.
1992: Tomas Mustelin; Tiina Pessa-Morikawa; M Autero; M Gassmann; Leif C Andersson; Carl G Gahmberg; P Burn
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.
European journal of immunology 1992;22(5):1173-8.
1992: Kurt Amrein; N Flint; B Panholzer; P Burn
Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3343-6.
1992: H Cho; S E Ramer; M Itoh; E Kitas; W Bannwarth; P Burn; H Saito; Christopher T Walsh
Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism.
Biochemistry 1992;31(1):133-8.
1992: M Gassmann; M Guttinger; Kurt Amrein; P Burn
Protein tyrosine kinase p59fyn is associated with the T cell receptor-CD3 complex in functional human lymphocytes.
European journal of immunology 1992;22(1):283-6.
1991: H J Cho; S E Ramer; M Itoh; D G Winkler; E Kitas; W Bannwarth; P Burn; H Saito; Christopher T Walsh
Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system.
Biochemistry 1991;30(25):6210-6.