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Lucio Merlini

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Alberto Bargiotti; Walter Cabri; Massimo Castorina; Maria Luisa Cervoni; Andrea Ciacci; Sabrina Dallavalle; Michelandrea De Cesare; Grazia Gallo; Giuseppe Giannini; Chiara Giommarelli; Lucio Merlini; Ferdinando Maria Milazzo; Loana Musso; Sergio Penco; Claudio Pisano; Loredana Vesci; Valentina Zuco; Marcella Barbarino; Franco Zunino
Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.
Giuseppe Giannini; Mario Berardino Guglielmi; Lucio Merlini; Raffaella Nannei; Claudio Pisano; Gianandrea Quattrociocchi; Loredana Vesci; Domenico Alloatti; Gianfranco Battistuzzi; Tiziana Brunetti; Federica Bucci; Maria Grazia Cima; Raffaella Cincinelli; Sabrina Dallavalle; Rosanna Foderà; Walter Cabri
New retinoid derivatives as back-ups of Adarotene.
Salvatore Cananzi; Roberto Artali; Giovanni Luca Beretta; Lucio Merlini; Nadia Zaffaroni; Sabrina Dallavalle
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.

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All Publications

2012: Alberto Bargiotti; Walter Cabri; Massimo Castorina; Maria Luisa Cervoni; Andrea Ciacci; Sabrina Dallavalle; Michelandrea De Cesare; Grazia Gallo; Giuseppe Giannini; Chiara Giommarelli; Lucio Merlini; Ferdinando Maria Milazzo; Loana Musso; Sergio Penco; Claudio Pisano; Loredana Vesci; Valentina Zuco; Marcella Barbarino; Franco Zunino
Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.
European journal of medicinal chemistry 2012;53():64-75.
2012: Giuseppe Giannini; Mario Berardino Guglielmi; Lucio Merlini; Raffaella Nannei; Claudio Pisano; Gianandrea Quattrociocchi; Loredana Vesci; Domenico Alloatti; Gianfranco Battistuzzi; Tiziana Brunetti; Federica Bucci; Maria Grazia Cima; Raffaella Cincinelli; Sabrina Dallavalle; Rosanna Foderà; Walter Cabri
New retinoid derivatives as back-ups of Adarotene.
Bioorganic & medicinal chemistry 2012;20(7):2405-15.
2011: Salvatore Cananzi; Roberto Artali; Giovanni Luca Beretta; Lucio Merlini; Nadia Zaffaroni; Sabrina Dallavalle
Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D.
Bioorganic & medicinal chemistry 2011;19(16):4971-84.
2010: Loana Musso; Sabrina Dallavalle; Lucio Merlini; Adriana Bava; Gianluca Nasini; Sergio Penco; Giuseppe Giannini; Chiara Giommarelli; Andrea De Cesare; Valentina Zuco; Loredana Vesci; Claudio Pisano; Massimo Castorina; Ferdinando Milazzo; Maria Luisa Cervoni; Fabrizio Dal Piaz; Nunziatina De Tommasi; Franco Zunino
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
Bioorganic & medicinal chemistry 2010;18(16):6031-43.
2010: Sonia Gattinoni; Chiara De Simone; Sabrina Dallavalle; Filomena Fezza; Raffaella Nannei; Natalia Battista; Patrizia Minetti; Gianandrea Quattrociocchi; Antonio Caprioli; Franco Borsini; Walter Cabri; Sergio Penco; Lucio Merlini; Mauro Maccarrone
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2010;20(15):4406-11.
2010: Loana Musso; Sabrina Dallavalle; Lucio Merlini; Gandolfina Farina
Synthesis and antifungal activity of 2-hydroxy-4,5-methylenedioxyaryl ketones as analogues of kakuol.
Chemistry & biodiversity 2010;7(4):887-97.
2010: Sonia Gattinoni; Chiara De Simone; Sabrina Dallavalle; Filomena Fezza; Raffaella Nannei; Daniele Amadio; Patrizia Minetti; Gianandrea Quattrociocchi; Antonio Caprioli; Franco Borsini; Walter Cabri; Sergio Penco; Lucio Merlini; Mauro Maccarrone
Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.
ChemMedChem 2010;5(3):357-60.
2009: Sabrina Dallavalle; Raffaella Cincinelli; Raffaella Nannei; Lucio Merlini; Gabriella Morini; Sergio Penco; Claudio Pisano; Loredana Vesci; Marcella Barbarino; Valentina Zuco; Michelandrea De Cesare; Franco Zunino
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
European journal of medicinal chemistry 2009;44(5):1900-12.
2009: Pierre Vekhoff; Ludovic Halby; Kahina Oussedik; Sabrina Dallavalle; Lucio Merlini; Christine Mahieu; Amélie Lansiaux; Christian Bailly; Alexandre Boutorine; Claudio Pisano; Giuseppe Giannini; Domenico Alloatti; Paola B Arimondo
Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan.
Bioconjugate chemistry 2009;20(4):666-72.
2008: Raffaella Cincinelli; Giuliana Cassinelli; Sabrina Dallavalle; Cinzia Lanzi; Lucio Merlini; Maurizio Botta; Tiziano Tuccinardi; Adriano Martinelli; Sergio Penco; Franco Zunino
Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.
Journal of medicinal chemistry 2008;51(24):7777-87.
2008: Claudia Valli; Gabriela Paroni; Angela Maria Di Francesco; Riccardo Riccardi; Michele Tavecchio; Eugenio Erba; Andrea Boldetti; Maurizio Gianni'; Maddalena Fratelli; Claudio Pisano; Lucio Merlini; Antonio Antoccia; Chiara Cenciarelli; Mineko Terao; Enrico Garattini
Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.
Molecular cancer therapeutics 2008;7(9):2941-54.
2008: Claudio Pisano; Michelandrea De Cesare; Giovanni Luca Beretta; Valentina Zuco; Graziella Pratesi; Sergio Penco; Loredana Vesci; Rosanna Foderà; Fabiana Fosca Ferrara; Mario Berardino Guglielmi; Paolo Carminati; Sabrina Dallavalle; Gabriella Morini; Lucio Merlini; Augusto Orlandi; Franco Zunino
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
Molecular cancer therapeutics 2008;7(7):2051-9.
2008: Sabrina Dallavalle; Daniela Granza Rocchetta; Loana Musso; Lucio Merlini; Gabriella Morini; Sergio Penco; Stella Tinelli; Giovanni Luca Beretta; Franco Zunino
Synthesis and cytotoxic activity of new 9-substituted camptothecins.
Bioorganic & medicinal chemistry letters 2008;18(9):2781-7.
2008: Sabrina Dallavalle; Sonia Gattinoni; Stefania Mazzini; Leonardo Scaglioni; Lucio Merlini; Stella Tinelli; Giovanni Luca Beretta; Franco Zunino
Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(4):1484-9.
2007: Anna Arnoldi; Sabrina Dallavalle; Lucio Merlini; Loana Musso; Gandolfina Farina; Maddalena Moretti; Lalith Jayasinghe
Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines.
Journal of agricultural and food chemistry 2007;55(20):8187-92.
2007: Raffaella Cincinelli; Sabrina Dallavalle; Raffaella Nannei; Lucio Merlini; Sergio Penco; Giuseppe Giannini; Claudio Pisano; Loredana Vesci; Fabiana Fosca Ferrara; Valentina Zuco; Chiara Zanchi; Franco Zunino
Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids.
Bioorganic & medicinal chemistry 2007;15(14):4863-75.
2007: Michelandrea De Cesare; Giovanni Luca Beretta; Stella Tinelli; Valentina Benedetti; Graziella Pratesi; Sergio Penco; Sabrina Dallavalle; Lucio Merlini; Claudio Pisano; Paolo Carminati; Franco Zunino
Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series.
Biochemical pharmacology 2007;73(5):656-64.
2006: edoardo parrella; Maurizio Giannì; Maddalena Fratelli; Maria Monica Barzago; Ivan Raska; Luisa Diomede; Mami Kurosaki; Claudio Pisano; Paolo Carminati; Lucio Merlini; Sabrina Dallavalle; Michele Tavecchio; Cécile Rochette-Egly; Mineko Terao; Enrico Garattini
Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways.
Molecular pharmacology 2006;70(3):909-24.
2006: Sabrina Dallavalle; Giuseppe Giannini; Domenico Alloatti; Andrea Casati; Elena Marastoni; Loana Musso; Lucio Merlini; Gabriella Morini; Sergio Penco; Claudio Pisano; Stella Tinelli; Michelandrea De Cesare; Giovanni Luca Beretta; Franco Zunino
Synthesis and cytotoxic activity of polyamine analogues of camptothecin.
Journal of medicinal chemistry 2006;49(17):5177-86.
2006: Raffaella Nannei; Sabrina Dallavalle; Lucio Merlini; Adriana Bava; Gianluca Nasini
Synthesis of (+)-spirolaxine methyl ether.
The Journal of organic chemistry 2006;71(16):6277-80.
2005: Eleonora Rizzi; Sabrina Dallavalle; Lucio Merlini; Giovanni Luca Beretta; Graziella Pratesi; Franco Zunino
A new synthesis of isoaurones: cytotoxic activity of compounds related to the alleged structure of isoaurostatin.
Bioorganic & medicinal chemistry letters 2005;15(19):4313-6.
2005: Raffaella Cincinelli; Sabrina Dallavalle; Raffaella Nannei; Serena Carella; Daniele De Zani; Lucio Merlini; Sergio Penco; Enrico Garattini; Giuseppe Giannini; Claudio Pisano; Loredana Vesci; Paolo Carminati; Valentina Zuco; Chiara Zanchi; Franco Zunino
Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity.
Journal of medicinal chemistry 2005;48(15):4931-46.
2004: Sabrina Dallavalle; Lucio Merlini; Giovanni Luca Beretta; Stella Tinelli; Franco Zunino
Synthesis and cytotoxic activity of substituted luotonin A derivatives.
Bioorganic & medicinal chemistry letters 2004;14(23):5757-61.
2004: Claudio Pisano; Lucio Merlini; Sergio Penco; Paolo Carminati; Franco Zunino
Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926.
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():74-6.
2004: Sabrina Dallavalle; Lucio Merlini; Gabriella Morini; Loana Musso; Sergio Penco; Giovanni Luca Beretta; Stella Tinelli; Franco Zunino
Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin.
European journal of medicinal chemistry 2004;39(6):507-13.
2004: Sabrina Dallavalle; Lalith Jayasinghe; B M M Kumarihamy; Lucio Merlini; Loana Musso; Leonardo Scaglioni
A new 3,4-seco-lupane derivative from Lasianthus gardneri.
Journal of natural products 2004;67(5):911-3.
2004: Enrico Garattini; edoardo parrella; Luisa Diomede; Maurizio Gianni'; Yesim Kalac; Lucio Merlini; Daniele Simoni; Romina Zanier; Fabiana Fosca Ferrara; Ilaria Chiarucci; Paolo Carminati; Mineko Terao; Claudio Pisano
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis.
Blood 2004;103(1):194-207.
2003: Giulia Bianchi; Sabrina Dallavalle; Lucio Merlini; Gianluca Nasini; Sergio Quaroni
A new azoxyalkene from a strain of an actinomadura-like fungus.
Planta medica 2003;69(6):574-6.
2003: Barbara Biasotti; Sabrina Dallavalle; Lucio Merlini; Carlo Farina; Stefania Gagliardi; Carlo Parini; Pietro Belfiore
Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase.
Bioorganic & medicinal chemistry 2003;11(10):2247-54.
2003: Raffaella Cincinelli; Sabrina Dallavalle; Lucio Merlini; Sergio Penco; Claudio Pisano; Paolo Carminati; Giuseppe Giannini; Loredana Vesci; carlo gaetano; Barbara Illy; Valentina Zuco; Rosanna Supino; Franco Zunino
A novel atypical retinoid endowed with proapoptotic and antitumor activity.
Journal of medicinal chemistry 2003;46(6):909-12.
2002: Graziella Pratesi; Michelandrea De Cesare; Nives Carenini; Paola Perego; Sabina C Righetti; Carla Cucco; Lucio Merlini; Claudio Pisano; Sergio Penco; Paolo Carminati; Loredana Vesci; Franco Zunino
Pattern of antitumor activity of a novel camptothecin, ST1481, in a large panel of human tumor xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3904-9.
2002: Angela Bassoli; Michael G B Drew; Lucio Merlini; Gabriella Morini
General pseudoreceptor model for sweet compounds: a semiquantitative prediction of binding affinity for sweet-tasting molecules.
Journal of medicinal chemistry 2002;45(20):4402-9.
2002: U L B Jayasinghe; Champika P Jayasooriya; B M R Bandara; S P Ekanayake; Lucio Merlini; G Assante
Antimicrobial activity of some Sri Lankan Rubiaceae and Meliaceae.
Fitoterapia 2002;73(5):424-7.
2001: Michelandrea De Cesare; Graziella Pratesi; Paola Perego; Nives Carenini; Stella Tinelli; Lucio Merlini; Sergio Penco; Claudio Pisano; Federica Bucci; Loredana Vesci; S Pace; F Capocasa; Paolo Carminati; Franco Zunino
Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.
Cancer research 2001;61(19):7189-95.
2001: Sabrina Dallavalle; A Ferrari; Barbara Biasotti; Lucio Merlini; Sergio Penco; Grazia Gallo; MAURO MARZI; Maria Ornella Tinti; Roberta Martinelli; Claudio Pisano; Paolo Carminati; Nives Carenini; Giovanni Luca Beretta; Paola Perego; Michelandrea De Cesare; Graziella Pratesi; Franco Zunino
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity.
Journal of medicinal chemistry 2001;44(20):3264-74.
2001: Sabrina Dallavalle; A Ferrari; Lucio Merlini; Sergio Penco; Nives Carenini; Michelandrea De Cesare; Paola Perego; Graziella Pratesi; Franco Zunino
Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin.
Bioorganic & medicinal chemistry letters 2001;11(3):291-4.
2000: Sabrina Dallavalle; T Delsoldato; A Ferrari; Lucio Merlini; Sergio Penco; Nives Carenini; Paola Perego; Michelandrea De Cesare; Graziella Pratesi; Franco Zunino
Novel 7-substituted camptothecins with potent antitumor activity.
Journal of medicinal chemistry 2000;43(21):3963-9.
2000: Anna Arnoldi; Raffaella Carzaniga; G Morini; Lucio Merlini; Gandolfina Farina
Synthesis, fungicidal activity, and QSAR of a series of 2-dichlorophenyl-3-triazolylpropyl ethers.
Journal of agricultural and food chemistry 2000;48(6):2547-55.
2000: Lucio Merlini; Gianluca Nasini; Leonardo Scaglioni; Giuliana Cassinelli; Cinzia Lanzi
Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases.
Phytochemistry 2000;53(8):1039-41.
1997: Alberto Arnone; Gianluca Nasini; Orso Vajna de Pava; Lucio Merlini
Constituents of Dragon's Blood. 5. Dracoflavans B1, B2, C1, C2, D1, and D2, new A-type deoxyproanthocyanidins.
Journal of natural products 1997;60(10):971-5.
1992: Aldo Feriani; Giovanni Gaviraghi; G Toson; B Valsecchi; P Caldirola; M Ravasi; Lucio Merlini; C Redaelli; E Grana; F Zonta
A novel class of cholinergic agents structurally related to 2-morpholinol.
Farmaco (Società chimica italiana : 1989) 1992;47(1):3-20.
1991: Anna Arnoldi; Lucio Merlini; M L Quadri; A Bonsignori; Piero Melloni; Mario Varasi
Synthesis and anticonvulsant activity of some benzopyranone imino derivatives of GABA and related compounds.
Farmaco (Società chimica italiana : 1989) 1991;46(5):629-38.
1990: Anna Arnoldi; A Bonsignori; Piero Melloni; Lucio Merlini; M L Quadri; A C Rossi; M Valsecchi
Synthesis and anticonvulsant and sedative-hypnotic activity of 4-(alkylimino)-2,3-dihydro-4H-1-benzopyrans and -benzothiopyrans.
Journal of medicinal chemistry 1990;33(10):2865-9.
1989: Lucio Merlini; M Pinza
Trends in searching for new cognition enhancing drugs.
Progress in neuro-psychopharmacology & biological psychiatry 1989;13 Suppl():S61-75.
1987: U Weiss; Lucio Merlini; Gianluca Nasini
Naturally occurring perylenequinones.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1987;52():1-71.
1984: N Bizzozero; Lucio Merlini; J T Coyle
Synthesis of C-analogues of kainic acids and their interaction with brain receptors.
Il Farmaco; edizione scientifica 1984;39(7):612-7.
1980: G Bertoni; Lucio Merlini; G Nasini; U Abenaim
1-Methyl-beta-carboline-3-carboxylic acid, an unusual metabolite from cows fed with corn silage.
Journal of agricultural and food chemistry 1980;28(3):672-3.
1970: Lucio Merlini; G Nasini; A Selva
The structure of funicone. A new metabolite from Penicillium funiculosum thom.
Tetrahedron 1970;26(11):2739-49.
1970: Lucio Merlini; R Mondelli; G Nasini; M Hesse
The structure of roxburghines A-E, new indole alkaloids from an Uncaria Sp.
Tetrahedron 1970;26(10):2259-79.
1967: G Cardillo; Lucio Merlini; R Mondelli; A Selva
Natural chromenes. IV. Structure and synthesis of desoxyhomoflemingin.
La Ricerca scientifica 1967;37(10):826-8.
1967: Lucio Merlini; R Mendelli; G Nasini; M Hesse
Gambirine, a new indole alkaloid from Uncaria gambier roxb.
Tetrahedron letters 1967;16():1571-4.