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Diogenes Santos

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Mycobacterium tuberculosis

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Ardala Breda; Pablo Machado; Leonardo Astolfi Rosado; Diogenes Santos; André Arigony Souto; Luiz Augusto Basso
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.
Luís Fernando Saraiva Macedo Timmers; Luiz Augusto Basso; Rodrigo Gay Ducati; Zilpa Adriana Sánchez-Quitian; Diogenes Santos; Walter Filgueira de Azevedo
Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv.
José E S Nunes; Mario S Palma; Leonardo Rosado; Diogenes Santos; Ardala Breda; Bibiana M de Souza; Rodrigo G Ducati; Luiz Augusto Basso
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23).

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2012: Ardala Breda; Pablo Machado; Leonardo Astolfi Rosado; Diogenes Santos; André Arigony Souto; Luiz Augusto Basso
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.
European journal of medicinal chemistry 2012;54():113-22.
2012: Luís Fernando Saraiva Macedo Timmers; Luiz Augusto Basso; Rodrigo Gay Ducati; Zilpa Adriana Sánchez-Quitian; Diogenes Santos; Walter Filgueira de Azevedo
Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv.
Journal of molecular modeling 2012;18(2):467-79.
2011: José E S Nunes; Mario S Palma; Leonardo Rosado; Diogenes Santos; Ardala Breda; Bibiana M de Souza; Rodrigo G Ducati; Luiz Augusto Basso
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23).
Archives of biochemistry and biophysics 2011;512(2):143-53.
2011: Zilpa A Sánchez-Quitian; Luís F S M Timmers; Rafael A Caceres; Jacqueline G Rehm; Claudia E Thompson; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.
Archives of biochemistry and biophysics 2011;509(1):108-15.
2011: Leonardo Krás Borges Martinelli; Rodrigo Gay Ducati; Leonardo Rosado; Ardala Breda; Bruna Pelegrim Selbach; Diogenes Santos; Luiz Augusto Basso
Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation.
Molecular bioSystems 2011;7(4):1289-305.
2011: Diana C Rostirolla; Ardala Breda; Leonardo Rosado; Mario S Palma; Luiz Augusto Basso; Diogenes Santos
UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation.
Archives of biochemistry and biophysics 2011;505(2):202-12.
2011: R G Ducati; Ardala Breda; Luiz Augusto Basso; Diogenes Santos
Purine Salvage Pathway in Mycobacterium tuberculosis.
Current medicinal chemistry 2011;18(9):1258-75.
2011: A D Villela; Z A Sánchez-Quitian; R G Ducati; Diogenes Santos; Luiz Augusto Basso
Pyrimidine salvage pathway in Mycobacterium tuberculosis.
Current medicinal chemistry 2011;18(9):1286-98.
2011: D M Saidemberg; A W Passarelli; A V Rodrigues; Luiz Augusto Basso; Diogenes Santos; Mario Palma
Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development.
Current medicinal chemistry 2011;18(9):1299-310.
2010: Eraldo L Batista; C Deves; L Ayub; R G da Silva; L C C Filho; Luiz Augusto Basso; Diogenes Santos
Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease.
Journal of periodontal research 2010;45(5):664-71.
2010: Rodrigo G Ducati; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry 2010;18(13):4769-74.
2009: Gisele Biazus; Cristopher Z Schneider; Mario Palma; Luiz Augusto Basso; Diogenes Santos
Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.
Protein expression and purification 2009;66(2):185-90.
2009: Rodrigo G Ducati; Diogenes Santos; Luiz Augusto Basso
Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Archives of biochemistry and biophysics 2009;486(2):155-64.
2008: Luis Fernando Saraiva Macedo Timmers; Rafael Andrade Caceres; Ana Luiza Vivan; Lisandra Marques Gava; Raquel Dias; Rodrigo Gay Ducati; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function.
Archives of biochemistry and biophysics 2008;479(1):28-38.
2008: Ana Luiza Vivan; Rafael Andrade Caceres; Jose Ramon Beltran Abrego; Júlio César Borges; João Ruggiero Neto; Carlos H I Ramos; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis.
Proteins 2008;72(4):1352-62.
2008: Helen A Arcuri; Júlio Borges; Isabel O Fonseca; José H Pereira; João Ruggiero Neto; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis.
Proteins 2008;72(2):720-30.
2008: Rafael Andrade Caceres; Luis Fernando Saraiva Timmers; Raquel Dias; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae.
Bioorganic & medicinal chemistry 2008;16(9):4984-93.
2008: Rafael Andrade Caceres; Luís Fernando Saraiva Macedo Timmers; Ana Luiza Vivan; Cristopher Zandoná Schneider; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.
Journal of molecular modeling 2008;14(5):427-34.
2008: Rafael Silva; Leonardo Rosado; Diogenes Santos; Luiz Augusto Basso
Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding.
Archives of biochemistry and biophysics 2008;471(1):1-10.
2008: L F S M Timmers; R A Caceres; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structural bioinformatics study of PNP from Listeria monocytogenes.
Protein and peptide letters 2008;15(8):843-9.
2008: Fernanda Ely; José E S Nunes; Evelyn K Schroeder; Jeverson Frazzon; Mario Palma; Diogenes Santos; Luiz Augusto Basso
The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase.
BMC biochemistry 2008;9():13.
2008: Ana Ls Vanz; Gaby Renard; Mario Palma; Jocelei M Chies; Sérgio L Dalmora; Luiz A Basso; Diogenes Santos
Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization.
Microbial cell factories 2008;7():13.
2008: Cristopher Z Schneider; Tanya Parish; Luiz Augusto Basso; Diogenes Santos
The two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids.
Journal of bacteriology 2008;190(1):122-34.
2007: Brenno A D Neto; Alexandre A M Lapis; Fabiana S Mancilha; Igor B Vasconcelos; Caroline Thum; Luiz Augusto Basso; Diogenes Santos; Jairton Dupont
New sensitive fluorophores for selective DNA detection.
Organic letters 2007;9(20):4001-4.
2007: Marcio Vinicius Bertacine Dias; Igor B Vasconcelos; Adriane Michele Xavier Prado; Valmir Fadel; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Journal of structural biology 2007;159(3):369-80.
2007: Jordana Dutra de Mendonça; Fernanda Ely; Mario Palma; Jeverson Frazzon; Luiz Augusto Basso; Diogenes Santos
Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification.
Journal of bacteriology 2007;189(17):6246-52.
2007: Hermides Pinto; Claudia Giuliano Bica; Moisés Palaci; Reynaldo Dietze; Luiz Augusto Basso; Diogenes Santos
Using polymerase chain reaction with primers based on the plcB-plcC intergenic region to detect Mycobacterium tuberculosis in clinical samples.
Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2007;33(4):437-42.
2007: José Henrique Pereira; Igor B Vasconcelos; Jaim S Oliveira; Rafael A Caceres; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Shikimate kinase: a potential target for development of novel antitubercular agents.
Current drug targets 2007;8(3):459-68.
2007: Maurício Ribeiro Marques; José Henrique Pereira; Jaim S Oliveira; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos; Mario Palma
The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials.
Current drug targets 2007;8(3):445-57.
2007: Marcio Vinicius Bertacine Dias; Fernanda Ely; Mario Palma; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Chorismate synthase: an attractive target for drug development against orphan diseases.
Current drug targets 2007;8(3):437-44.
2007: R G Ducati; Luiz Augusto Basso; Diogenes Santos
Mycobacterial shikimate pathway enzymes as targets for drug design.
Current drug targets 2007;8(3):423-35.
2007: Rafael Silva; J E S Nunes; Fernanda Canduri; Júlio Borges; L M Gava; Frederico Bruno Mendes Batista Moreno; Luiz Augusto Basso; Diogenes Santos
Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases.
Current drug targets 2007;8(3):413-22.
2007: Jaim S Oliveira; Igor B Vasconcelos; Icaro S Moreira; Diogenes Santos; Luiz Augusto Basso
Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.
Current drug targets 2007;8(3):399-411.
2007: Cláudia Lemelle Fernandes; Ardala Breda; Diogenes Santos; Luiz Augusto Basso; Osmar Norberto de Souza
A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate.
Computers in biology and medicine 2007;37(2):149-58.
2007: Isabel O Fonseca; Rafael Silva; Claudia L Fernandes; Osmar N de Souza; Luiz Augusto Basso; Diogenes Santos
Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis.
Archives of biochemistry and biophysics 2007;457(2):123-33.
2007: Ardala Breda; Diogenes Santos; Luiz Augusto Basso; Osmar N de Souza
Ab initio 3-D structure prediction of an artificially designed three-alpha-helix bundle via all-atom molecular dynamics simulations.
Genetics and molecular research : GMR 2007;6(4):901-10.
2007: Marcio Vinicius Bertacine Dias; Lívia Maria Faím; Igor B Vasconcelos; Jaim Simões de Oliveira; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 1):1-6.
2006: Rodrigo Gay Ducati; Antonio Ruffino-Netto; Luiz Augusto Basso; Diogenes Santos
The resumption of consumption -- a review on tuberculosis.
Memórias do Instituto Oswaldo Cruz 2006;101(7):697-714.
2006: Rafael Silva; Luiz Pedro Carvalho; John S Blanchard; Diogenes Santos; Luiz Augusto Basso
Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.
Biochemistry 2006;45(43):13064-73.
2006: Júlio Borges; José Henrique Pereira; Igor B Vasconcelos; Giovanni César dos Santos; Johnny Rizzieri Olivieri; Carlos H I Ramos; Mario Palma; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis.
Archives of biochemistry and biophysics 2006;452(2):156-64.
2006: Jaim S Oliveira; José Henrique Pereira; Fernanda Canduri; Nathália C Rodrigues; Osmar N de Souza; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis.
Journal of molecular biology 2006;359(3):646-66.
2006: Andreia Leopoldino; Fernanda Canduri; Hamilton Cabral; Magno Junqueira; Alessandra Bernadete Trovó de Marqui; Luciano H Apponi; Isabel Osório da Fonseca; Gilberto B Domont; Diogenes Santos; Sandro Valentini; Gustavo Orlando Bonilla-Rodriguez; Marcelo Andrés Fossey; Walter Filgueira de Azevedo; Eloiza H Tajara
Expression, purification, and circular dichroism analysis of human CDK9.
Protein expression and purification 2006;47(2):614-20.
2006: Marcio Vinicius Bertacine Dias; Júlio Borges; Fernanda Ely; José Henrique Pereira; Fernanda Canduri; Carlos H I Ramos; Jeverson Frazzon; Mario Palma; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structure of chorismate synthase from Mycobacterium tuberculosis.
Journal of structural biology 2006;154(2):130-43.
2006: Ana Luiza Vivan; Marcio Vinicius Bertacine Dias; Cristopher Z Schneider; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Crystallization and preliminary X-ray diffraction analysis of prephenate dehydratase from Mycobacterium tuberculosis H37Rv.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 4):357-60.
2006: Isabel O Fonseca; Maria L B Magalhães; Jaim S Oliveira; Rafael Silva; Maria Anita Mendes; Mario Palma; Diogenes Santos; Luiz Augusto Basso
Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization.
Protein expression and purification 2006;46(2):429-37.
2006: Eduardo Walker Zettler; Rosane Machado Scheibe; Cícero A Dias; Patrícia Santafé; Diogenes Santos; José da Silva Moreira; Carlos Cezar Fritscher
Determination of penicillin resistance in Streptococcus pneumoniae isolates from southern Brazil by PCR.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2006;10(2):110-5.
2006: Jaim S Oliveira; Eduardo H S de Sousa; Osmar N de Souza; Icaro S Moreira; Diogenes Santos; Luiz Augusto Basso
Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.
Current pharmaceutical design 2006;12(19):2409-24.
2006: Walter Filgueira de Azevedo; Fernanda Canduri; Luiz Augusto Basso; Mario Palma; Diogenes Santos
Determining the structural basis for specificity of ligands using crystallographic screening.
Cell biochemistry and biophysics 2006;44(3):405-11.
2006: Marcio Vinicius Bertacine Dias; Fernanda Canduri; Nelson José Freitas da Silveira; clarissa czekster; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo
Molecular models of tryptophan synthase from mycobacterium tuberculosis complexed with inhibitors.
Cell biochemistry and biophysics 2006;44(3):375-84.
2005: Luiz Augusto Basso; Luiz Hildebrando Pereira da Silva; Arthur G Fett-Neto; Walter Filgueira de Azevedo; Icaro de Souza Moreira; Mario Palma; João B Calixto; Spartaco Astolfi-Filho; Ricardo Ribeiro dos Santos; Milena B P Soares; Diogenes Santos
The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review.
Memórias do Instituto Oswaldo Cruz 2005;100(6):475-506.
2005: Rafael Silva; José Henrique Pereira; Fernanda Canduri; Walter Filgueira de Azevedo; Luiz Augusto Basso; Diogenes Santos
Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine.
Archives of biochemistry and biophysics 2005;442(1):49-58.
2005: Evelyn Koeche Schroeder; Luiz Augusto Basso; Diogenes Santos; Osmar N de Souza
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities.
Biophysical journal 2005;89(2):876-84.
2005: Fernanda Canduri; Rafael Silva; Denis Marangoni dos Santos; Mario Palma; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structure of human PNP complexed with ligands.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 7):856-62.
2005: Nelson José Freitas da Silveira; Hugo Brandão Uchôa; José Henrique Pereira; Fernanda Canduri; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo
Molecular models of protein targets from Mycobacterium tuberculosis.
Journal of molecular modeling 2005;11(2):160-6.
2005: Caroline Rizzi; Jeverson Frazzon; Fernanda Ely; Patrícia G Weber; Isabel Osório da Fonseca; Michelle Gallas; Jaim S Oliveira; Maria Anita Mendes; Bibiana Monson de Souza; Mario Palma; Diogenes Santos; Luiz Augusto Basso
DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme.
Protein expression and purification 2005;40(1):23-30.
2005: Fernanda Canduri; Valmir Fadel; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo
New catalytic mechanism for human purine nucleoside phosphorylase.
Biochemical and biophysical research communications 2005;327(3):646-9.
2005: Eduardo Sousa; Daniel L Pontes; Izaura C N Diógenes; Luiz G F Lopes; Jaim S Oliveira; Luiz Augusto Basso; Diogenes Santos; Icaro S Moreira
Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs.
Journal of inorganic biochemistry 2005;99(2):368-75.
2005: Fernanda Canduri; Valmir Fadel; Marcio Vinicius Bertacine Dias; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo
Crystal structure of human PNP complexed with hypoxanthine and sulfate ion.
Biochemical and biophysical research communications 2005;326(2):335-8.
2004: José Henrique Pereira; Jaim Simões de Oliveira; Fernanda Canduri; Marcio Vinicius Bertacine Dias; Mario Palma; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Interaction of shikimic acid with shikimate kinase.
Biochemical and biophysical research communications 2004;325(1):10-7.
2004: José Henrique Pereira; Jaim Simões de Oliveira; Fernanda Canduri; Marcio Vinicius Bertacine Dias; Mario Palma; Luiz Augusto Basso; Diogenes Santos; Walter Filgueira de Azevedo
Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 12 Pt 2):2310-9.
2004: Diego O Nolasco; Fernanda Canduri; José Henrique Pereira; Janaina R Cortinóz; Mario Palma; Jaim S Oliveira; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9A resolution.
Biochemical and biophysical research communications 2004;324(2):789-94.
2004: Marcio Vinicius Bertacine Dias; Fernanda Ely; Fernanda Canduri; José Henrique Pereira; Jeverson Frazzon; Luiz Augusto Basso; Mario Palma; Walter Filgueira de Azevedo; Diogenes Santos
Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 11):2003-5.
2004: Rafael Silva; Diogenes Santos; Luiz Augusto Basso; Jean Pierre Oses; Susana Wofchuk; Luis V Portela; Diogo O Souza
Purine nucleoside phosphorylase activity in rat cerebrospinal fluid.
Neurochemical research 2004;29(10):1831-5.
2004: Nelson José Freitas da Silveira; Hugo Brandão Uchôa; Fernanda Canduri; José Henrique Pereira; João Carlos Camera; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo
Structural bioinformatics study of PNP from Schistosoma mansoni.
Biochemical and biophysical research communications 2004;322(1):100-4.
2004: Helen Andrade Arcuri; Fernanda Canduri; José Henrique Pereira; Nelson José Freitas da Silveira; João Carlos Camera Júnior; Jaim Simões de Oliveira; Luiz Augusto Basso; Mario Palma; Diogenes Santos; Walter Filgueira de Azevedo Júnior
Molecular models for shikimate pathway enzymes of Xylella fastidiosa.
Biochemical and biophysical research communications 2004;320(3):979-91.
2004: Simone S Poletto; Isabel Osório da Fonseca; Luiz Pedro Carvalho; Luiz Augusto Basso; Diogenes Santos
Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes.
Protein expression and purification 2004;34(1):118-25.
2004: Jaim S Oliveira; Eduardo Sousa; Luiz Augusto Basso; Moisés Palaci; Reynaldo Dietze; Diogenes Santos; Icaro S Moreira
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
Chemical communications (Cambridge, England) 2004;(3):312-3.
2004: Fernanda Canduri; Denis Marangoni dos Santos; Rafael Silva; Maria Anita Mendes; Luiz Augusto Basso; Mario Palma; Walter Filgueira de Azevedo; Diogenes Santos
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI.
Biochemical and biophysical research communications 2004;313(4):907-14.
2003: Walter Filgueira de Azevedo; Fernanda Canduri; Denis Marangoni dos Santos; José Henrique Pereira; Márcio Vinicius Bertacine Dias; Rafael Silva; Maria Anita Mendes; Luiz Augusto Basso; Mario Palma; Diogenes Santos
Crystal structure of human PNP complexed with guanine.
Biochemical and biophysical research communications 2003;312(3):767-72.
2003: José Henrique Pereira; Fernanda Canduri; Jaim Simões de Oliveira; Nelson José Freitas da Silveira; Luiz Augusto Basso; Mario Palma; Walter Filgueira de Azevedo; Diogenes Santos
Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis.
Biochemical and biophysical research communications 2003;312(3):608-14.
2003: Walter Filgueira de Azevedo; Giovanni César dos Santos; Denis Marangoni dos Santos; Johnny Rizzieri Olivieri; Fernanda Canduri; Rafael Silva; Luiz Augusto Basso; Gaby Renard; Isabel Osório da Fonseca; Maria Anita Mendes; Mario Palma; Diogenes Santos
Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase.
Biochemical and biophysical research communications 2003;309(4):923-8.
2003: Walter Filgueira de Azevedo; Fernanda Canduri; Denis Marangoni dos Santos; José Henrique Pereira; Marcio Vinicius Bertacine Dias; Rafael Silva; Maria Anita Mendes; Luiz Augusto Basso; Mario Palma; Diogenes Santos
Structural basis for inhibition of human PNP by immucillin-H.
Biochemical and biophysical research communications 2003;309(4):917-22.
2003: Denis Marangoni dos Santos; Fernanda Canduri; José Henrique Pereira; Márcio Vinicius Bertacine Dias; Rafael Silva; Maria Anita Mendes; Mario Palma; Luiz Augusto Basso; Walter Filgueira de Azevedo; Diogenes Santos
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.
Biochemical and biophysical research communications 2003;308(3):553-9.
2003: Walter Filgueira de Azevedo; Fernanda Canduri; Denis Marangoni dos Santos; Rafael Silva; Jaim Simões de Oliveira; Luiz Pedro Carvalho; Luiz Augusto Basso; Maria Anita Mendes; Mario Palma; Diogenes Santos
Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution.
Biochemical and biophysical research communications 2003;308(3):545-52.
2003: J P M Senna; Daniela Martino Roth; Jaim S Oliveira; Denise Cantarelli Machado; Diogenes Santos
Protective immune response against methicillin resistant Staphylococcus aureus in a murine model using a DNA vaccine approach.
Vaccine 2003;21(19-20):2661-6.
2003: Andrzej Lewandowicz; Wuxian Shi; Gary B Evans; Peter C Tyler; Richard H Furneaux; Luiz A Basso; Diogenes Santos; Steven C Almo; Vern L Schramm
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.
Biochemistry 2003;42(20):6057-66.
2003: Anthony A Sauve; Sean M Cahill; Stephan G Zech; Luiz A Basso; Andrzej Lewandowicz; Diogenes Santos; Charles Grubmeyer; Gary B Evans; Richard H Furneaux; Peter C Tyler; Ann McDermott; Mark E Girvin; Vern L Schramm
Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
Biochemistry 2003;42(19):5694-705.
2003: Jaim S Oliveira; Maria Anita Mendes; Mario Palma; Luiz Augusto Basso; Diogenes Santos
One-step purification of 5-enolpyruvylshikimate-3-phosphate synthase enzyme from Mycobacterium tuberculosis.
Protein expression and purification 2003;28(2):287-92.
2003: Rafael Silva; Luiz Pedro Carvalho; Jaim S Oliveira; Clotilde A Pinto; Maria Anita Mendes; Mario Palma; Luiz Augusto Basso; Diogenes Santos
Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase.
Protein expression and purification 2003;27(1):158-64.
2002: Maria L B Magalhães; Clarissa P Pereira; Luiz Augusto Basso; Diogenes Santos
Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv.
Protein expression and purification 2002;26(1):59-64.
2002: E K Schroeder; N de Souza; Diogenes Santos; John S Blanchard; Luiz Augusto Basso
Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.
Current pharmaceutical biotechnology 2002;3(3):197-225.
2002: Walter Filgueira de Azevedo; Fernanda Canduri; Jaim Simões de Oliveira; Luiz Augusto Basso; Mario Palma; José Henrique Pereira; Diogenes Santos
Molecular model of shikimate kinase from Mycobacterium tuberculosis.
Biochemical and biophysical research communications 2002;295(1):142-8.
2002: J P M Senna; Clotilde A Pinto; Luiz Pedro Carvalho; Diogenes Santos
Comparison of pulsed-field gel electrophoresis and PCR analysis of polymorphisms on the mec hypervariable region for typing methicillin-resistant Staphylococcus aureus.
Journal of clinical microbiology 2002;40(6):2254-6.
2001: Jaim S Oliveira; Clotilde A Pinto; Luiz Augusto Basso; Diogenes Santos
Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis.
Protein expression and purification 2001;22(3):430-5.
2001: Wuxian Shi; Luiz A Basso; Diogenes Santos; Peter C Tyler; Richard H Furneaux; John S Blanchard; Steven C Almo; Vern L Schramm
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry 2001;40(28):8204-15.
2001: Luiz A Basso; Diogenes Santos; Wuxian Shi; Richard H Furneaux; Peter C Tyler; Vern L Schramm; John S Blanchard
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
Biochemistry 2001;40(28):8196-203.