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Frédéric Flamant

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Frédéric Flamant; Karine Gauthier
Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response.
Fabrice Chatonnet; Romain Guyot; Frédéric Picou; Maria Bondesson; Frédéric Flamant
Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons.
Teddy Fauquier; Fabrice Chatonnet; Xuan-Nhi Nguyen; Frédéric Picou; Laure Quignodon; Eva Romero; Frédéric Flamant
Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform.

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All Publications

2013: Frédéric Flamant; Karine Gauthier
Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response.
Biochimica et biophysica acta 2013;1830(7):3900-7.
2012: Fabrice Chatonnet; Romain Guyot; Frédéric Picou; Maria Bondesson; Frédéric Flamant
Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons.
PloS one 2012;7(5):e30703.
2011: Teddy Fauquier; Fabrice Chatonnet; Xuan-Nhi Nguyen; Frédéric Picou; Laure Quignodon; Eva Romero; Frédéric Flamant
Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform.
Developmental biology 2011;356(2):350-8.
2011: Fabrice Chatonnet; Teddy Fauquier; Frédéric Picou; Frédéric Flamant
Thyroid hormone action in cerebellum and cerebral cortex development.
Journal of thyroid research 2011;2011():145762.
2010: Arturo Hernandez; Laure Quignodon; M Elena Martinez; Frédéric Flamant; Donald L St Germain
Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels.
Endocrinology 2010;151(11):5550-8.
2010: Frédéric Flamant; Laure Quignodon
Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.
Heart failure reviews 2010;15(2):117-20.
2010: Francis Béby; Michael Housset; Nicolas Fossat; Coralie Le Greneur; Frédéric Flamant; Pierre Godement; Thomas Lamonerie
Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.
PloS one 2010;5(7):e11673.
2008: J H Duncan Bassett; Allan J Williams; Elaine Murphy; Alan Boyde; Peter G T Howell; Rowan Swinhoe; Marta Archanco; Frédéric Flamant; Jacques Samarut; Sabine Costagliola; Gilbert Vassart; Roy E Weiss; Samuel Refetoff; Graham R Williams
A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):501-12.
2008: Frédéric Flamant; Laure Quignodon
[Thyroid hormone and its receptors: have mouse genetics clarified the situation?].
Journal de la Société de biologie 2008;202(2):67-71.
2007: Laure Quignodon; Séverine Vincent; Harald Winter; Jacques Samarut; Frédéric Flamant
A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.
Molecular endocrinology (Baltimore, Md.) 2007;21(10):2350-60.
2007: Laure Quignodon; Carmen Grijota-Martinez; Emmanuel Compe; Romain Guyot; Nathalie Allioli; David Laperrière; Robert Walker; Paul Meltzer; Sylvie Mader; Jacques Samarut; Frédéric Flamant
A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum.
Journal of molecular endocrinology 2007;39(1):17-28.
2007: Carole Crozet; Stéphane Lezmi; Frédéric Flamant; Jacques Samarut; Thierry Baron; Anna Bencsik
Peripheral circulation of the prion infectious agent in transgenic mice expressing the ovine prion protein gene in neurons only.
The Journal of infectious diseases 2007;195(7):997-1006.
2007: Ouria Dkhissi-Benyahya; Claude Gronfier; Wena De Vanssay; Frédéric Flamant; Howard M Cooper
Modeling the role of mid-wavelength cones in circadian responses to light.
Neuron 2007;53(5):677-87.
2007: Frédéric Flamant; Karine Gauthier; Jacques Samarut
Thyroid hormones signaling is getting more complex: STORMs are coming.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):321-33.
2006: Frédéric Flamant; John D Baxter; Douglas Forrest; Samuel Refetoff; Herbert Samuels; Thomas S Scanlan; Björn Vennström; Jacques Samarut
International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors.
Pharmacological reviews 2006;58(4):705-11.
2004: Laure Quignodon; Claude Legrand; Nathalie Allioli; Ana Guadaño-Ferraz; Juan Bernal; Jacques Samarut; Frédéric Flamant
Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development.
Journal of molecular endocrinology 2004;33(2):467-76.
2004: Wilfried Mai; Marc Janier; Nathalie Allioli; Laure Quignodon; Thomas Chuzel; Frédéric Flamant; Jacques Samarut
Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10332-7.
2004: E Bonnafe; M Touka; A AitLounis; Dominique Baas; Emmanuèle Barras; C Ucla; A Moreau; Frédéric Flamant; R Dubruille; Pierre Couble; J Collignon; Bénédicte Durand; Walter Reith
The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification.
Molecular and cellular biology 2004;24(10):4417-27.
2004: Sandrine Dupre; Hajer Guissouma; Frédéric Flamant; Isabelle Seugnet; Thomas S Scanlan; John D Baxter; Jacques Samarut; Barbara A Demeneix; Nathalie Becker
Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone.
Endocrinology 2004;145(5):2337-45.
2003: Paul M Yen; Xu Feng; Frédéric Flamant; Yidong Chen; Robert L Walker; Roy E Weiss; Olivier Chassande; Jacques Samarut; Samuel Refetoff; Paul S Meltzer
Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice.
EMBO reports 2003;4(6):581-7.
2003: Frédéric Flamant; Jacques Samarut
Thyroid hormone receptors: lessons from knockout and knock-in mutant mice.
Trends in endocrinology and metabolism: TEM 2003;14(2):85-90.
2003: Anne-Lise Poguet; Claude Legrand; Xu Feng; Paul M Yen; Paul Meltzer; Jacques Samarut; Frédéric Flamant
Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.
Developmental biology 2003;254(2):188-99.
2002: Dominique Baas; Claude Legrand; Jacques Samarut; Frédéric Flamant
Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2907-11.
2002: Karine Gauthier; Denise Aubert; Olivier Chassande; Frédéric Flamant; Jacques Samarut
Null mutant mice for thyroid hormone receptors.
Methods in molecular biology (Clifton, N.J.) 2002;202():13-29.
2002: Frédéric Flamant; Anne-Lise Poguet; Michelina Plateroti; Olivier Chassande; Karine Gauthier; Nathalie Streichenberger; Ahmed Mansouri; Jacques Samarut
Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene.
Molecular endocrinology (Baltimore, Md.) 2002;16(1):24-32.
2001: Carole Crozet; Anna Bencsik; Frédéric Flamant; Stéphane Lezmi; Jacques Samarut; Thierry Baron
Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE.
EMBO reports 2001;2(10):952-6.
2001: Carole Crozet; Frédéric Flamant; Anna Bencsik; D Aubert; Jacques Samarut; Thierry Baron
Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene.
Journal of virology 2001;75(11):5328-34.
1999: Tony Sourisseau; Yves Le Dréan; Gilles Salbert; Frédéric Flamant; Denis Michel
Eukaryotic conditional expression system.
BioTechniques 1999;27(1):106-10.
1999: V Revol; I Tsuboi; Frédéric Flamant; J Samarut; JP Blanchet; Guy Mouchiroud
A novel growth-factor-dependent myeloid cell line derived from mouse bone marrow cells contains progenitors endowed with high proliferative potential.
Experimental hematology 1999;27(1):88-98.
1998: Frédéric Flamant; Jacques Samarut
Involvement of thyroid hormone and its alpha receptor in avian neurulation.
Developmental biology 1998;197(1):1-11.
1997: Olivier Chassande; Alexandre Fraichard; Karine Gauthier; Frédéric Flamant; Claude Legrand; Pierre Savatier; Vincent Laudet; Jacques Samarut
Identification of transcripts initiated from an internal promoter in the c-erbA alpha locus that encode inhibitors of retinoic acid receptor-alpha and triiodothyronine receptor activities.
Molecular endocrinology (Baltimore, Md.) 1997;11(9):1278-90.
1996: F Solari; Frédéric Flamant; Y Cherel; Monique Wyers; Pierre Jurdic
The osteoclast generation: an in vitro and in vivo study with a genetically labelled avian monocytic cell line.
Journal of cell science 1996;109 ( Pt 6)():1203-13.
1995: Frédéric Flamant; J Samarut
Virofection: a one-step procedure for using replication-defective retrovirus vectors.
Virology 1995;211(1):234-40.
1995: Frédéric Flamant; F L Cosset; Jacques Samarut
Vectors derived from avian leukosis and sarcoma viruses.
Journal of molecular medicine (Berlin, Germany) 1995;73(4):181-7.
1995: Jacques Samarut; Frédéric Flamant; J M Heard
Replication-competent and -defective retrovirus vectors for oncogenic studies.
Methods in enzymology 1995;254():206-28.
1994: Frédéric Flamant; B Demeneix; C Benoist; S Markossian-Belin; J Samarut
Virofection: a new procedure to achieve stable expression of genes transferred into early embryos.
The International journal of developmental biology 1994;38(4):751-7.
1993: François-Loïc Cosset; A Girod; Frédéric Flamant; A Drynda; C Ronfort; S Valsesia; R M Molina; C Faure; V M Nigon; Gérard Verdier
Use of helper cells with two host ranges to generate high-titer retroviral vectors.
Virology 1993;193(1):385-95.
1993: Frédéric Flamant; D Aubert; C Legrand; François-Loïc Cosset; Jacques Samarut
Importance of 3' non-coding sequences for efficient retrovirus-mediated gene transfer in avian cells revealed by self-inactivating vectors.
The Journal of general virology 1993;74 ( Pt 1)():39-46.
1992: Madeleine Douaire; N Le Fur; C el Khadir-Mounier; P Langlois; Frédéric Flamant; J Mallard
Identifying genes involved in the variability of genetic fatness in the growing chicken.
Poultry science 1992;71(11):1911-20.
1992: François-Loïc Cosset; C Ronfort; R M Molina; Frédéric Flamant; A Drynda; M Benchaibi; S Valsesia; V M Nigon; Gérard Verdier
Packaging cells for avian leukosis virus-based vectors with various host ranges.
Journal of virology 1992;66(9):5671-6.
1988: Frédéric Flamant; J A Sorge
In vitro synthesis of infectious retroviral RNA.
Journal of virology 1988;62(5):1827-31.
1987: Frédéric Flamant; C C Gurin; J A Sorge
An embryonic DNA-binding protein specific for the promoter of the retrovirus long terminal repeat.
Molecular and cellular biology 1987;7(10):3548-53.
1987: Frédéric Flamant; D Le Guellec; Gérard Verdier; V M Nigon
Tissue specificity of retrovirus expression in inoculated avian embryos revealed by in situ hybridization to whole-body section.
Virology 1987;160(1):301-4.