Username

Password

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Philip Tsichlis

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Anatomy

Cell Line

Physiology

Genes & Molecular Sequences

Disorders

Neoplastic Cell Transformation

Phenomena

Phosphorylation

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Androulidaki Ariadne; Iliopoulos Dimitrios; Arranz Alicia; Doxaki Christina; Schworer Steffen; Zacharioudaki Vassiliki; Margioris Andrew N; Tsichlis Philip N; Tsatsanis Christos
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Tzatsos Alexandros; Pfau Raymond; Kampranis Sotirios C; Tsichlis Philip N
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Hu Miaofen G; Deshpande Amit; Enos Miriam; Mao Daqin; Hinds Elisabeth A; Hu Guo-fu; Chang Rui; Guo Zhuyan; Dose Marei; Mao Changchuin; Tsichlis Philip N; Gounari Fotini; Hinds Philip W
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Philip Tsichlis (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Androulidaki Ariadne; Iliopoulos Dimitrios; Arranz Alicia; Doxaki Christina; Schworer Steffen; Zacharioudaki Vassiliki; Margioris Andrew N; Tsichlis Philip N; Tsatsanis Christos
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Immunity 2009;31(2):220-31.
2009: Tzatsos Alexandros; Pfau Raymond; Kampranis Sotirios C; Tsichlis Philip N
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2641-6.
2009: Hu Miaofen G; Deshpande Amit; Enos Miriam; Mao Daqin; Hinds Elisabeth A; Hu Guo-fu; Chang Rui; Guo Zhuyan; Dose Marei; Mao Changchuin; Tsichlis Philip N; Gounari Fotini; Hinds Philip W
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.
Cancer research 2009;69(3):810-8.
2009: Iliopoulos Dimitrios; Polytarchou Christos; Hatziapostolou Maria; Kottakis Filippos; Maroulakou Ioanna G; Struhl Kevin; Tsichlis Philip N
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.
Science signaling 2009;2(92):ra62.
2008: Polytarchou Christos; Pfau Raymond; Hatziapostolou Maria; Tsichlis Philip N
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress.
Molecular and cellular biology 2008;28(24):7451-64.
2008: Watford Wendy T; Hissong Bruce D; Durant Lydia R; Yamane Hidehiro; Muul Linda M; Kanno Yuka; Tato Cristina M; Ramos Haydeé L; Berger Alan E; Mielke Lisa; Pesu Marko; Solomon Benjamin; Frucht David M; Paul William E; Sher Alan; Jankovic Dragana; Tsichlis Philip N; O'Shea John J
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
The Journal of experimental medicine 2008;205(12):2803-12.
2008: Maroulakou Ioanna G; Oemler William; Naber Stephen P; Klebba Ina; Kuperwasser Charlotte; Tsichlis Philip N
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.
Journal of cellular physiology 2008;217(2):468-77.
2008: Wright Gary L; Maroulakou Ioanna G; Eldridge Juanita; Liby Tiera L; Sridharan Vijayalakshmi; Tsichlis Philip N; Muise-Helmericks Robin C
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3264-75.
2008: Hatziapostolou Maria; Polytarchou Christos; Panutsopulos Dimitrios; Covic Lidija; Tsichlis Philip N
Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.
Cancer research 2008;68(6):1851-61.
2008: Tsatsanis Christos; Vaporidi Katerina; Zacharioudaki Vassiliki; Androulidaki Ariadne; Sykulev Yuri; Margioris Andrew N; Tsichlis Philip N
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2987-92.
2008: Pfau Raymond; Tzatsos Alexandros; Kampranis Sotirios C; Serebrennikova Oksana B; Bear Susan E; Tsichlis Philip N
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1907-12.
2007: Odat Osama; Matta Samer; Khalil Hadi; Kampranis Sotirios C; Pfau Raymond; Tsichlis Philip N; Makris Antonios M
Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
The Journal of biological chemistry 2007;282(49):36010-23.
2007: Robinson M J; Beinke S; Kouroumalis A; Tsichlis P N; Ley S C
Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.
Molecular and cellular biology 2007;27(21):7355-64.
2007: Van Acker Gijs J D; Perides George; Weiss Eric R; Das Santasabuj; Tsichlis Philip N; Steer Michael L
Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis.
The Journal of biological chemistry 2007;282(30):22140-9.
2007: Black Terrence M; Andrews Christine L; Kilili Geoffrey; Ivan Mircea; Tsichlis Philip N; Vouros Paul
Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.
Journal of proteome research 2007;6(6):2269-76.
2007: Tzatsos Alexandros; Tsichlis Philip N
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
The Journal of biological chemistry 2007;282(25):18069-82.
2007: Mao Changchuin; Tili Esmerina G; Dose Marei; Haks Mariëlle C; Bear Susan E; Maroulakou Ioanna; Horie Kyoji; Gaitanaris George A; Fidanza Vincenzo; Ludwig Thomas; Wiest David L; Gounari Fotini; Tsichlis Philip N
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5443-53.
2007: Tsichlis Philip N; Hatziapostolou Maria; Hinds Philip W
Timing is everything: regulation of Cdk1 and aneuploidy.
Developmental cell 2007;12(4):477-9.
2007: Maroulakou Ioanna G; Oemler William; Naber Stephen P; Tsichlis Philip N
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Cancer research 2007;67(1):167-77.
2006: Tomczak Michal F; Gadjeva Mihaela; Wang Yan Yan; Brown Ketorah; Maroulakou Ioanna; Tsichlis Philip N; Erdman Susan E; Fox James G; Horwitz Bruce H
Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):1244-51.
2006: Shao Zhili; Bhattacharya Kausik; Hsich Eileen; Park Larry; Walters Brian; Germann Ursula; Wang Yow-Ming; Kyriakis John; Mohanlal Ramon; Kuida Keisuke; Namchuk Mark; Salituro Francesco; Yao Yung-mae; Hou Wei-min; Chen Xin; Aronovitz Mark; Tsichlis Philip N; Bhattacharya Susmita; Force Thomas; Kilter Heiko
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
Circulation research 2006;98(1):111-8.
2006: Eliopoulos Aristides G; Das Santasabuj; Tsichlis Philip N
The tyrosine kinase Syk regulates TPL2 activation signals.
The Journal of biological chemistry 2006;281(3):1371-80.
2006: Cittadini A; Monti M G; Iaccarino G; Di Rella F; Tsichlis P N; Di Gianni A; Strömer H; Sorriento D; Peschle C; Trimarco B; Saccà L; Condorelli G
Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling.
Gene therapy 2006;13(1):8-19.
2005: Vaporidi Katerina; Tsatsanis Christos; Georgopoulos Dimitris; Tsichlis Philip N
Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells.
Life sciences 2005;78(3):284-93.
2005: Du Keyong; Tsichlis Philip N
Regulation of the Akt kinase by interacting proteins.
Oncogene 2005;24(50):7401-9.
2005: Testa Joseph R; Tsichlis Philip N
AKT signaling in normal and malignant cells.
Oncogene 2005;24(50):7391-3.
2005: Das Santasabuj; Cho Jeonghee; Lambertz Irina; Kelliher Michelle A; Eliopoulos Aristides G; Du Keyong; Tsichlis Philip N
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
The Journal of biological chemistry 2005;280(25):23748-57.
2005: Cho Jeonghee; Melnick Michael; Solidakis Georgios P; Tsichlis Philip N
Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.
The Journal of biological chemistry 2005;280(21):20442-8.
2005: Cho Jeonghee; Tsichlis Philip N
Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2350-5.
2004: Bieganowski Pawel; Shilinski Kara; Tsichlis Philip N; Brenner Charles
Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance.
The Journal of biological chemistry 2004;279(43):44656-66.
2004: Doan Loretta L; Porter Susan D; Duan Zhijun; Flubacher Marcella M; Montoya Diego; Tsichlis Philip N; Horwitz Marshall; Gilks C Blake; Grimes H Leighton
Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.
Nucleic acids research 2004;32(8):2508-19.
2003: Eliopoulos Aristides G; Wang Chun-Chi; Dumitru Calin D; Tsichlis Philip N
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.
The EMBO journal 2003;22(15):3855-64.
2003: Grille Sylvia Julien; Bellacosa Alfonso; Upson John; Klein-Szanto Andres J; van Roy Frans; Lee-Kwon Whaseon; Donowitz Mark; Tsichlis Philip N; Larue Lionel
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
Cancer research 2003;63(9):2172-8.
2003: Hoyal Carolyn R; Gutierrez Abel; Young Brandon M; Catz Sergio D; Lin Jun-Hsiang; Tsichlis Philip N; Babior Bernard M
Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5130-5.
2003: Doan Loretta L; Kitay Mary Kate; Yu Qing; Singer Alfred; Herblot Sabine; Hoang Trang; Bear Susan E; Morse Herbert C; Tsichlis Philip N; Grimes H Leighton
Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2356-66.
2002: Kontoyiannis Dimitris; Boulougouris George; Manoloukos Menelaos; Armaka Maria; Apostolaki Maria; Pizarro Theresa; Kotlyarov Alexey; Forster Irmgard; Flavell Richard; Gaestel Matthias; Tsichlis Philip; Cominelli Fabio; Kollias George
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
The Journal of experimental medicine 2002;196(12):1563-74.
2002: Condorelli Gianluigi; Morisco Carmine; Latronico Michael V G; Claudio Pier Paolo; Dent Paul; Tsichlis Philip; Condorelli Gerolama; Frati Giacomo; Drusco Alessandra; Croce Carlo M; Napoli Claudio
TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1732-7.
2002: Das Santasabuj; Lin Jun-Hsiang; Papamatheakis Joseph; Sykulev Yuri; Tsichlis Philip N
Differential splicing generates Tvl-1/RFXANK isoforms with different functions.
The Journal of biological chemistry 2002;277(47):45172-80.
2002: Viglietto Giuseppe; Motti Maria Letizia; Bruni Paola; Melillo Rosa Marina; D'Alessio Amelia; Califano Daniela; Vinci Floriana; Chiappetta Gennaro; Tsichlis Philip; Bellacosa Alfonso; Fusco Alfredo; Santoro Massimo
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Nature medicine 2002;8(10):1136-44.
2002: Basso Andrea D; Solit David B; Chiosis Gabriela; Giri Banabihari; Tsichlis Philip; Rosen Neal
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
The Journal of biological chemistry 2002;277(42):39858-66.
2002: Eliopoulos Aristides G; Dumitru Calin D; Wang Chun-Chi; Cho Jeonghee; Tsichlis Philip N
Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.
The EMBO journal 2002;21(18):4831-40.
2002: Zhu Jinfang; Guo Liying; Min Booki; Watson Cynthia J; Hu-Li Jane; Young Howard A; Tsichlis Philip N; Paul William E
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.
Immunity 2002;16(5):733-44.
2002: Eliopoulos Aristides G; Davies Clare; Blake Sarah S M; Murray Paul; Najafipour Sohrab; Tsichlis Philip N; Young Lawrence S
The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2.
Journal of virology 2002;76(9):4567-79.
2002: Chan Tung O; Rodeck Ulrich; Chan Andrew M; Kimmelman Alec C; Rittenhouse Susan E; Panayotou George; Tsichlis Philip N
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.
Cancer cell 2002;1(2):181-91.
2001: Malstrom S; Tili E; Kappes D; Ceci J D; Tsichlis P N
Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14967-72.
2001: Sun M; Wang G; Paciga J E; Feldman R I; Yuan Z Q; Ma X L; Shelley S A; Jove R; Tsichlis P N; Nicosia S V; Cheng J Q
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.
The American journal of pathology 2001;159(2):431-7.
2001: Lee-Kwon W; Johns D C; Cha B; Cavet M; Park J; Tsichlis P; Donowitz M
Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3.
The Journal of biological chemistry 2001;276(33):31296-304.
2001: Mende I; Malstrom S; Tsichlis P N; Vogt P K; Aoki M
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.
Oncogene 2001;20(32):4419-23.
2001: Patriotis C; Russeva M G; Lin J H; Srinivasula S M; Markova D Z; Tsatsanis C; Makris A; Alnemri E S; Tsichlis P N
Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3.
Journal of cellular physiology 2001;187(2):176-87.
2001: Chan T O; Tsichlis P N
PDK2: a complex tail in one Akt.
Science's STKE : signal transduction knowledge environment 2001;2001(66):pe1.
2000: Dumitru C D; Ceci J D; Tsatsanis C; Kontoyiannis D; Stamatakis K; Lin J H; Patriotis C; Jenkins N A; Copeland N G; Kollias G; Tsichlis P N
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.
Cell 2000;103(7):1071-83.
2000: Poyet J L; Srinivasula S M; Lin J H; Fernandes-Alnemri T; Yamaoka S; Tsichlis P N; Alnemri E S
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
The Journal of biological chemistry 2000;275(48):37966-77.
2000: Kampranis S C; Damianova R; Atallah M; Toby G; Kondi G; Tsichlis P N; Makris A M
A novel plant glutathione S-transferase/peroxidase suppresses Bax lethality in yeast.
The Journal of biological chemistry 2000;275(38):29207-16.
2000: De Vita G; Berlingieri M T; Visconti R; Castellone M D; Viglietto G; Baldassarre G; Zannini M; Bellacosa A; Tsichlis P N; Fusco A; Santoro M
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects.
Cancer research 2000;60(14):3916-20.
2000: De Vita G; Melillo R M; Carlomagno F; Visconti R; Castellone M D; Bellacosa A; Billaud M; Fusco A; Tsichlis P N; Santoro M
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Cancer research 2000;60(14):3727-31.
2000: Morisco C; Zebrowski D; Condorelli G; Tsichlis P; Vatner S F; Sadoshima J
The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes.
The Journal of biological chemistry 2000;275(19):14466-75.
2000: Pekarsky Y; Koval A; Hallas C; Bichi R; Tresini M; Malstrom S; Russo G; Tsichlis P; Croce C M
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3028-33.
1999: Osada M; Tolkacheva T; Li W; Chan T O; Tsichlis P N; Saez R; Kimmelman A C; Chan A M
Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.
Molecular and cellular biology 1999;19(9):6333-44.
1999: Srinivasula S M; Ahmad M; Lin J H; Poyet J L; Fernandes-Alnemri T; Tsichlis P N; Alnemri E S
CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
The Journal of biological chemistry 1999;274(25):17946-54.
1999: Lin J H; Makris A; McMahon C; Bear S E; Patriotis C; Prasad V R; Brent R; Golemis E A; Tsichlis P N
The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1.
The Journal of biological chemistry 1999;274(21):14706-15.
1999: Kurowski T G; Lin Y; Luo Z; Tsichlis P N; Buse M G; Heydrick S J; Ruderman N B
Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.
Diabetes 1999;48(3):658-63.
1999: Grammatikakis N; Lin J H; Grammatikakis A; Tsichlis P N; Cochran B H
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function.
Molecular and cellular biology 1999;19(3):1661-72.
1999: Chan T O; Rittenhouse S E; Tsichlis P N
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation.
Annual review of biochemistry 1999;68():965-1014.
1998: Aoki M; Batista O; Bellacosa A; Tsichlis P; Vogt P K
The akt kinase: molecular determinants of oncogenicity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14950-5.
1998: Tsatsanis C; Patriotis C; Tsichlis P N
Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB.
Oncogene 1998;17(20):2609-18.
1998: Muise-Helmericks R C; Grimes H L; Bellacosa A; Malstrom S E; Tsichlis P N; Rosen N
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway.
The Journal of biological chemistry 1998;273(45):29864-72.
1998: Wang Y; Falasca M; Schlessinger J; Malstrom S; Tsichlis P; Settleman J; Hu W; Lim B; Prywes R
Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):513-22.
1998: Bellacosa A; Chan T O; Ahmed N N; Datta K; Malstrom S; Stokoe D; McCormick F; Feng J; Tsichlis P
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Oncogene 1998;17(3):313-25.
1998: Tong B; Grimes H L; Yang T Y; Bear S E; Qin Z; Du K; El-Deiry W S; Tsichlis P N
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
Molecular and cellular biology 1998;18(5):2462-73.
1998: Eves E M; Xiong W; Bellacosa A; Kennedy S G; Tsichlis P N; Rosner M R; Hay N
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
Molecular and cellular biology 1998;18(4):2143-52.
1998: Tsatsanis C; Patriotis C; Bear S E; Tsichlis P N
The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3827-32.
1997: Skorski T; Bellacosa A; Nieborowska-Skorska M; Majewski M; Martinez R; Choi J K; Trotta R; Wlodarski P; Perrotti D; Chan T O; Wasik M A; Tsichlis P N; Calabretta B
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.
The EMBO journal 1997;16(20):6151-61.
1997: King W G; Mattaliano M D; Chan T O; Tsichlis P N; Brugge J S
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.
Molecular and cellular biology 1997;17(8):4406-18.
1997: Chang H W; Aoki M; Fruman D; Auger K R; Bellacosa A; Tsichlis P N; Cantley L C; Roberts T M; Vogt P K
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.
Science (New York, N.Y.) 1997;276(5320):1848-50.
1997: Ahmed N N; Grimes H L; Bellacosa A; Chan T O; Tsichlis P N
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3627-32.
1997: Kennedy S G; Wagner A J; Conzen S D; Jordán J; Bellacosa A; Tsichlis P N; Hay N
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
Genes & development 1997;11(6):701-13.
1997: Ceci J D; Patriotis C P; Tsatsanis C; Makris A M; Kovatch R; Swing D A; Jenkins N A; Tsichlis P N; Copeland N G
Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Genes & development 1997;11(6):688-700.
1996: Grimes H L; Gilks C B; Chan T O; Porter S; Tsichlis P N
The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14569-73.
1996: Datta K; Bellacosa A; Chan T O; Tsichlis P N
Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells.
The Journal of biological chemistry 1996;271(48):30835-9.
1996: Grimes H L; Chan T O; Zweidler-McKay P A; Tong B; Tsichlis P N
The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal.
Molecular and cellular biology 1996;16(11):6263-72.
1996: Zweidler-Mckay P A; Grimes H L; Flubacher M M; Tsichlis P N
Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.
Molecular and cellular biology 1996;16(8):4024-34.
1995: Franke T F; Yang S I; Chan T O; Datta K; Kazlauskas A; Morrison D K; Kaplan D R; Tsichlis P N
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
Cell 1995;81(5):727-36.
1995: Gilks C B; Porter S D; Barker C; Tsichlis P N; Gout P W
Prolactin (PRL)-dependent expression of a zinc finger protein-encoding gene, Gfi-1, in Nb2 lymphoma cells: constitutive expression in autonomous sublines.
Endocrinology 1995;136(4):1805-8.
1995: Datta K; Franke T F; Chan T O; Makris A; Yang S I; Kaplan D R; Morrison D K; Golemis E A; Tsichlis P N
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation.
Molecular and cellular biology 1995;15(4):2304-10.
1995: Bell D W; Taguchi T; Jenkins N A; Gilbert D J; Copeland N G; Gilks C B; Zweidler-McKay P; Grimes H L; Tsichlis P N; Testa J R
Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents.
Cytogenetics and cell genetics 1995;70(3-4):263-7.
1994: Patriotis C; Tsichlis P N
The activated Mlvi-4 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas encodes an env/Mlvi-4 fusion protein.
Journal of virology 1994;68(12):7927-32.
1994: Flubacher M M; Bear S E; Tsichlis P N
Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis.
Journal of virology 1994;68(12):7709-16.
1994: Patriotis C; Makris A; Chernoff J; Tsichlis P N
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9755-9.
1994: Bellacosa A; Datta K; Bear S E; Patriotis C; Lazo P A; Copeland N G; Jenkins N A; Tsichlis P N
Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA.
Journal of virology 1994;68(4):2320-30.
1994: Franke T F; Tartof K D; Tsichlis P N
The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.
Oncogene 1994;9(1):141-8.
1993: Ahmed N N; Franke T F; Bellacosa A; Datta K; Gonzalez-Portal M E; Taguchi T; Testa J R; Tsichlis P N
The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.
Oncogene 1993;8(7):1957-63.
1993: Makris A; Patriotis C; Bear S E; Tsichlis P N
Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion.
Journal of virology 1993;67(7):4283-9.
1993: Barker C; Makris A; Patriotis C; Bear S E; Tsichlis P N
Identification of the gene encoding the mitochondrial elongation factor G in mammals.
Nucleic acids research 1993;21(11):2641-7.
1993: Gilks C B; Bear S E; Grimes H L; Tsichlis P N
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.
Molecular and cellular biology 1993;13(3):1759-68.
1993: Bellacosa A; Franke T F; Gonzalez-Portal M E; Datta K; Taguchi T; Gardner J; Cheng J Q; Testa J R; Tsichlis P N
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.
Oncogene 1993;8(3):745-54.
1993: Makris A; Patriotis C; Bear S E; Tsichlis P N
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
Journal of virology 1993;67(3):1286-91.
1993: Patriotis C; Makris A; Bear S E; Tsichlis P N
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2251-5.
1993: Yeung R S; Taguchi T; Patriotis C; Makris A; Tsichlis P N; Levan K K; Levan G; Tartof K; Hino O; Knudson A G; Testa J R
New markers, D16FC1 and Tp12, differentiate between rat chromosomes 16 and 17.
Cytogenetics and cell genetics 1993;62(2-3):149-52.
1993: Taguchi T; Bellacosa A; Zhou J Y; Gilbert D J; Lazo P A; Copeland N G; Jenkins N A; Tsichlis P N; Testa J R
Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents.
Cytogenetics and cell genetics 1993;64(3-4):217-21.
1992: Barker C S; Bear S E; Keler T; Copeland N G; Gilbert D J; Jenkins N A; Yeung R S; Tsichlis P N
Activation of the prolactin receptor gene by promoter insertion in a Moloney murine leukemia virus-induced rat thymoma.
Journal of virology 1992;66(11):6763-8.
1992: Cheng J Q; Godwin A K; Bellacosa A; Taguchi T; Franke T F; Hamilton T C; Tsichlis P N; Testa J R
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9267-71.
1991: Bellacosa A; Testa J R; Staal S P; Tsichlis P N
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
Science (New York, N.Y.) 1991;254(5029):274-7.
1991: Tsichlis P N; Bear S E
Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4611-5.
1991: Bellacosa A; Lazo P A; Bear S E; Tsichlis P N
The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation.
Molecular and cellular biology 1991;11(5):2864-72.
1991: Tsichlis P N; Lazo P A
Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses.
Current topics in microbiology and immunology 1991;171():95-171.
1990: Palumbo A P; Boccadoro M; Battaglio S; Corradini P; Tsichlis P N; Huebner K; Pileri A; Croce C M
Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3' of the myc gene, is rearranged in multiple myelomas.
Cancer research 1990;50(20):6478-82.
1990: Lazo P A; Klein-Szanto A J; Tsichlis P N
T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications.
Journal of virology 1990;64(8):3948-59.
1990: Lazo P A; Tsichlis P N
Biology and pathogenesis of retroviruses.
Seminars in oncology 1990;17(3):269-94.
1990: Tsichlis P N; Lee J S; Bear S E; Lazo P A; Patriotis C; Gustafson E; Shinton S; Jenkins N A; Copeland N G; Huebner K
Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus.
Journal of virology 1990;64(5):2236-44.
1990: Lazo P A; Lee J S; Tsichlis P N
Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):170-3.
1989: Bear S E; Bellacosa A; Lazo P A; Jenkins N A; Copeland N G; Hanson C; Levan G; Tsichlis P N
Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7495-9.
1989: Anagnou N P; Economou-Pachnis A; O'Brien S J; Modi W S; Nienhuis A W; Tsichlis P N
The human homolog of the Moloney leukemia virus integration 2 locus (MLV12) maps to band p14 of chromosome 5.
Genomics 1989;5(2):354-8.
1989: Tsichlis P N; Shepherd B M; Bear S E
Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5487-91.
1989: Bellacosa A; Lazo P A; Bear S E; Shinton S; Tsichlis P N
Induction of multiple independent T-cell lymphomas in rats inoculated with MOloney murine leukemia virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4269-72.
1989: Koehne C F; Lazo P A; Alves K; Lee J S; Tsichlis P N; O'Donnell P V
The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical.
Journal of virology 1989;63(5):2366-9.
1988: Lazo P A; Tsichlis P N
Recombination between two integrated proviruses, one of which was inserted near c-myc in a retrovirus-induced rat thymoma: implications for tumor progression.
Journal of virology 1988;62(3):788-94.
1987: Bassuk J A; Tsichlis P N; Sorof S
Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7547-51.
1987: Lazo P A; Prasad V; Tsichlis P N
Splice acceptor site for the env message of Moloney murine leukemia virus.
Journal of virology 1987;61(6):2038-41.
1987: Tsichlis P N
Oncogenesis by Moloney murine leukemia virus.
Anticancer research 1987;7(2):171-80.
1986: Wirschubsky Z; Tsichlis P; Klein G; Sumegi J
Rearrangement of c-myc, pim-1 and Mlvi-1 and trisomy of chromosome 15 in MCF- and Moloney-MuLV-induced murine T-cell leukemias.
International journal of cancer. Journal international du cancer 1986;38(5):739-45.
1986: Furano A V; Somerville C C; Tsichlis P N; D'Ambrosio E
Target sites for the transposition of rat long interspersed repeated DNA elements (LINEs) are not random.
Nucleic acids research 1986;14(9):3717-27.
1985: Economou-Pachnis A; Tsichlis P N
Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.
Nucleic acids research 1985;13(23):8379-87.
1985: Tsichlis P N; Lohse M A; Szpirer C; Szpirer J; Levan G
Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat.
Journal of virology 1985;56(3):938-42.
1985: Tsichlis P N; Strauss P G; Lohse M A
Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis.
Journal of virology 1985;56(1):258-67.
1985: Shank P R; Schatz P J; Jensen L M; Tsichlis P N; Coffin J M; Robinson H L
Sequences in the gag-pol-5'env region of avian leukosis viruses confer the ability to induce osteopetrosis.
Virology 1985;145(1):94-104.
1985: Economou-Pachnis A; Lohse M A; Furano A V; Tsichlis P N
Insertion of long interspersed repeated elements at the Igh (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus integration 2) loci of rats.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2857-61.
1985: Kozak C A; Strauss P G; Tsichlis P N
Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15.
Molecular and cellular biology 1985;5(4):894-7.
1985: Chang E H; Morgan P L; Lee E J; Pirollo K F; White E A; Patrick D H; Tsichlis P N
Pathogenicity of retroviruses containing either the normal human c-Ha-ras1 gene or its mutated form derived from the bladder carcinoma EJ/T24 cell line.
Journal of experimental pathology 1985;2(3):177-89.
1984: Laimins L A; Tsichlis P; Khoury G
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus.
Nucleic acids research 1984;12(16):6427-42.
1984: Tsichlis P N; Strauss P G; Kozak C A
Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.
Molecular and cellular biology 1984;4(5):997-1000.
1983: Coffin J M; Tsichlis P N; Conklin K F; Senior A; Robinson H L
Genomes of endogenous and exogenous avian retroviruses.
Virology 1983;126(1):51-72.
1983: Tsichlis P N; Strauss P G; Hu L F
A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas.
Nature 1983;302(5907):445-9.
1983: Robinson H L; Coffin J M; Tsichlis P N; Shank P R; Schatz P; Jensen L
Cancer induction by insertional mutagenesis: the role of viral genes in avian leukosis virus induced cancers.
Progress in clinical and biological research 1983;119():37-42.
1983: Skalka A M; Tsichlis P N; Malavarca R; Cullen B; Ju G
Viral sequences determining the oncogenicity of avian leukosis viruses.
Progress in clinical and biological research 1983;119():105-18.
1982: Tsichlis P N; Donehower L; Hager G; Zeller N; Malavarca R; Astrin S; Skalka A M
Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential.
Molecular and cellular biology 1982;2(11):1331-8.
1982: Robinson H L; Blais B M; Tsichlis P N; Coffin J M
At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1225-9.
1981: Lautenberger J A; Schulz R A; Garon C F; Tsichlis P N; Papas T S
Molecular cloning of avian myelocytomatosis virus (MC29) transforming sequences.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(3):1518-22.
1981: Coffin J M; Tsichlis P N; Robinson H L
Genetics of leukemogenesis by avian leukosis viruses.
Haematology and blood transfusion 1981;26():432-8.
1981: Lautenberger J A; Schulz R A; Garon C F; Tsichlis P N; Spyropoulos D D; Pry T W; Rushlow K E; Papas T S
The transforming sequences of avian myelocytomatosis virus (MC29).
Journal of supramolecular structure and cellular biochemistry 1981;16(2):193-207.
1980: Green N; Hiai H; Elder J H; Schwartz R S; Khiroya R H; Thomas C Y; Tsichlis P N; Coffin J M
Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice.
The Journal of experimental medicine 1980;152(2):249-64.
1980: Tsichlis P N; Coffin J M
Recombinants between endogenous and exogenous avian tumor viruses: role of the C region and other portions of the genome in the control of replication and transformation.
Journal of virology 1980;33(1):238-49.
1980: Tsichlis P N; Conklin K F; Coffin J M
Mutant and recombinant avian retroviruses with extended host range.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):536-40.
1980: Coffin J M; Tsichlis P N; Barker C S; Voynow S; Robinson H L
Variation in avian retrovirus genomes.
Annals of the New York Academy of Sciences 1980;354():410-25.
1980: Robinson H L; Pearson M N; DeSimone D W; Tsichlis P N; Coffin J M
Subgroup-E avian-leukosis-virus-associated disease in chickens.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1133-41.
1980: Tsichlis P N; Coffin J M
Role of the C region in relative growth rates of endogenous and exogenous avian oncoviruses.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1123-32.
1980: Bear S E; Tsichlis P N; Schwartz R S
H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance.
Immunogenetics 1980;11(5):451-65.
1979: Tsichlis P N; Coffin J M
Recombination between the defective component of an acute leukemia virus and Rous associated virus O, an endogenous virus of chickens.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(6):3001-5.
1979: Andrianakos A A; Tsichlis P N; Merikas E G; Efstratopoulos A D; Sharp J T; Marketos S G; Merikas G E
The effect of glucocorticosteroids on antigen-induced leukocyte migration inhibition.
Materia medica Polona. Polish journal of medicine and pharmacy 1979;11(1):10-4.
1977: Andrianakos A A; Tsichlis P N; Merikas E G; Marketos S G; Sharp J T; Merikas G E
Cell-mediated immunity in systemic lupus erythematosus.
Clinical and experimental immunology 1977;30(1):89-96.
1977: Safran C; Tsichlis P N; Bluming A Z; Desforges J F
Diagnostic planning using computer assisted decision-making for patients with Hodgkin's disease.
Cancer 1977;39(6):2426-34.
1977: Safran C; Desforges J F; Tsichlis P N; Bluming A Z
Decision analysis to evaluate lymphangiography in the management of patients with Hodgkin's disease.
The New England journal of medicine 1977;296(19):1088-92.
1977: Tucker HSt; Weens J; Tsichlis P; Schwartz R S; Khiroya R; Donnelly J
Influence of H-2 complex on susceptibility to infection by murine leukemia virus.
Journal of immunology (Baltimore, Md. : 1950) 1977;118(4):1239-43.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Philip Tsichlis

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Anatomy

Physiology

Genes & Molecular Sequences

Disorders

Phenomena

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Philip Tsichlis (preview)

All Publications