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ISabella Graef

Research Profile

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TOP 3
Shih-Chu Kao; Hai Wu; J Xie; Ching-Pin Chang; Jeffrey A Ranish; ISabella Graef; Gerald R Crabtree
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
Gerald R Crabtree; ISabella Graef
Bursting into the nucleus.
Jiang I Wu; Julie Lessard; Ivan A Olave; Zilong Qiu; Anirvan Ghosh; ISabella Graef; Gerald R Crabtree
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.

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All Publications

2009: Shih-Chu Kao; Hai Wu; J Xie; Ching-Pin Chang; Jeffrey A Ranish; ISabella Graef; Gerald R Crabtree
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
Science (New York, N.Y.) 2009;323(5914):651-4.
2008: Gerald R Crabtree; ISabella Graef
Bursting into the nucleus.
Science signaling 2008;1(51):pe54.
2007: Jiang I Wu; Julie Lessard; Ivan A Olave; Zilong Qiu; Anirvan Ghosh; ISabella Graef; Gerald R Crabtree
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
Neuron 2007;56(1):94-108.
2007: Julie Lessard; Jiang I Wu; Jeffrey A Ranish; Mimi Wan; Monte M Winslow; Brett T Staahl; Hai Wu; Ruedi Aebersold; ISabella Graef; Gerald R Crabtree
An essential switch in subunit composition of a chromatin remodeling complex during neural development.
Neuron 2007;55(2):201-15.
2007: Hai Wu; Alys Peisley; ISabella Graef; Gerald R Crabtree
NFAT signaling and the invention of vertebrates.
Trends in cell biology 2007;17(6):251-60.
2007: Xiang Zhou; J Ramesh Babu; Susana da Silva; Qing Shu; ISabella Graef; Timothy Oliver; Toshifumi Tomoda; Tomomi Tani; Marie W Wooten; Fan Wang
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5842-7.
2006: Teddy T C Yang; Hee Yun Suk; Xiaoyong Yang; Opeyemi Olabisi; Raymond Y L Yu; Jorge Durand; Linda Jelicks; Ja-Young Kim; Philipp E Scherer; Yuhua Wang; Yun Feng; Luciano Rossetti; ISabella Graef; Gerald R Crabtree; Chi-Wing Chow
Role of transcription factor NFAT in glucose and insulin homeostasis.
Molecular and cellular biology 2006;26(20):7372-87.
2006: Joseph R Arron; Monte M Winslow; Alberto Polleri; Ching-Pin Chang; Hai Wu; Xin Gao; Joel R Neilson; Lei Chen; Jeremy J Heit; Seung K Kim; Nobuyuki Yamasaki; Tsuyoshi Miyakawa; Uta Francke; ISabella Graef; Gerald R Crabtree
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Nature 2006;441(7093):595-600.
2005: M Bose; Jason E Gestwicki; V Devasthali; Gerald R Crabtree; ISabella Graef
'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation.
Biochemical Society transactions 2005;33(Pt 4):543-7.
2005: Teddy T C Yang; Qiufang Xiong; ISabella Graef; Gerald R Crabtree; Chi-Wing Chow
Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex.
Molecular and cellular biology 2005;25(3):907-20.
2004: Jason E Gestwicki; Gerald R Crabtree; ISabella Graef
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
Science (New York, N.Y.) 2004;306(5697):865-9.
2004: Ching-Pin Chang; Joel R Neilson; J Henri Bayle; Jason E Gestwicki; Ann Kuo; Kryn Stankunas; ISabella Graef; Gerald R Crabtree
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.
Cell 2004;118(5):649-63.
2003: ISabella Graef; Fan Wang; Frederic Charron; Lei Chen; Joel Neilson; Marc Tessier-Lavigne; Gerald R Crabtree
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
Cell 2003;113(5):657-70.
2001: ISabella Graef; F Chen; Gerald R Crabtree
NFAT signaling in vertebrate development.
Current opinion in genetics & development 2001;11(5):505-12.
2001: ISabella Graef; F Chen; Lei Chen; Ann Kuo; Gerald R Crabtree
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Cell 2001;105(7):863-75.
2001: ISabella Graef; Julie M Gastier-Foster; Uta Francke; Gerald R Crabtree
Evolutionary relationships among Rel domains indicate functional diversification by recombination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5740-5.
2001: A Behrens; Kanaga Sabapathy; ISabella Graef; M Cleary; Gerald R Crabtree; Erwin F Wagner
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1769-74.
2001: Kanaga Sabapathy; T Kallunki; Jean-Pierre David; ISabella Graef; Michael Karin; Erwin F Wagner
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.
The Journal of experimental medicine 2001;193(3):317-28.
1999: ISabella Graef; Paul G Mermelstein; Kryn Stankunas; Joel R Neilson; Karl Deisseroth; Richard W Tsien; Gerald R Crabtree
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.
Nature 1999;401(6754):703-8.
1999: Kryn Stankunas; ISabella Graef; Joel R Neilson; S H Park; Gerald R Crabtree
Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.
Cold Spring Harbor symposia on quantitative biology 1999;64():505-16.
1998: L J Holsinger; ISabella Graef; W Swat; T Chi; Diana M Bautista; L Davidson; Richard S Lewis; F W Alt; Gerald R Crabtree
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Current biology : CB 1998;8(10):563-72.
1997: ISabella Graef; L J Holsinger; S Diver; S L Schreiber; Gerald R Crabtree
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.
The EMBO journal 1997;16(18):5618-28.
1997: ISabella Graef; Gerald R Crabtree
The transcriptional paradox: octamer factors and B and T cells.
Science (New York, N.Y.) 1997;277(5323):193-4.
1996: S Ho; N Clipstone; L Timmermann; JP Northrop; ISabella Graef; D Fiorentino; J Nourse; Gerald R Crabtree
The mechanism of action of cyclosporin A and FK506.
Clinical immunology and immunopathology 1996;80(3 Pt 2):S40-5.
1995: D M Spencer; ISabella Graef; D J Austin; Stuart L Schreiber; Gerald R Crabtree
A general strategy for producing conditional alleles of Src-like tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9805-9.