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Perry Blackshear

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
36
Stumpo, Deborah
29
Lai, Wi
16
Buchwald, Henry
15
Rohde, TD
13
Kennington, Elizabeth
12
Carballo, Ester
9
Graff, Jonathan
6
Phillips, Ruth
6
Carrick, Danielle Mercatante
5
Cao, Heping
4
Zeldin, Darryl
4
Seldin, Michael
4
Wilson, Gerald
4
Gaestel, Matthias
4
Ramos, Silvia

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Publications

TOP 3
Weimer Jill M; Yokota Yukako; Stanco Amelia; Stumpo Deborah J; Blackshear Perry J; Anton E S
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.
Stumpo Deborah J; Broxmeyer Hal E; Ward Toni; Cooper Scott; Hangoc Giao; Chung Yang Jo; Shelley William C; Richfield Eric K; Ray Manas K; Yoder Mervin C; Aplan Peter D; Blackshear Perry J
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.
Schaljo Barbara; Kratochvill Franz; Gratz Nina; Sadzak Iwona; Sauer Ines; Hammer Michael; Vogl Claus; Strobl Birgit; Müller Mathias; Blackshear Perry J; Poli Valeria; Lang Roland; Murray Peter J; Kovarik Pavel
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

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All Publications

2009: Weimer Jill M; Yokota Yukako; Stanco Amelia; Stumpo Deborah J; Blackshear Perry J; Anton E S
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.
Development (Cambridge, England) 2009;136(17):2965-75.
2009: Stumpo Deborah J; Broxmeyer Hal E; Ward Toni; Cooper Scott; Hangoc Giao; Chung Yang Jo; Shelley William C; Richfield Eric K; Ray Manas K; Yoder Mervin C; Aplan Peter D; Blackshear Perry J
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.
Blood 2009;114(12):2401-10.
2009: Schaljo Barbara; Kratochvill Franz; Gratz Nina; Sadzak Iwona; Sauer Ines; Hammer Michael; Vogl Claus; Strobl Birgit; Müller Mathias; Blackshear Perry J; Poli Valeria; Lang Roland; Murray Peter J; Kovarik Pavel
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1197-206.
2009: Brennan Sarah E; Kuwano Yuki; Alkharouf Nadim; Blackshear Perry J; Gorospe Myriam; Wilson Gerald M
The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis.
Cancer research 2009;69(12):5168-76.
2009: Tudor Corina; Marchese Francesco P; Hitti Edward; Aubareda Anna; Rawlinson Lesley; Gaestel Matthias; Blackshear Perry J; Clark Andrew R; Saklatvala Jeremy; Dean Jonathan L E
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.
FEBS letters 2009;583(12):1933-8.
2009: Ogilvie Rachel L; Sternjohn Julius R; Rattenbacher Bernd; Vlasova Irina A; Williams Darlisha A; Hau Heidi H; Blackshear Perry J; Bohjanen Paul R
Tristetraprolin mediates interferon-gamma mRNA decay.
The Journal of biological chemistry 2009;284(17):11216-23.
2009: Horner Thierry J; Lai Wi S; Stumpo Deborah J; Blackshear Perry J
Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.
Molecular and cellular biology 2009;29(8):1999-2010.
2008: Gay Elaine A; Klein Rebecca C; Melton Mark A; Blackshear Perry J; Yakel Jerrel L
Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide.
The Journal of pharmacology and experimental therapeutics 2008;327(3):884-90.
2008: Frederick Elizabeth D; Ramos Silvia B V; Blackshear Perry J
A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3.
The Journal of biological chemistry 2008;283(21):14792-800.
2008: Stoecklin Georg; Tenenbaum Scott A; Mayo Thomas; Chittur Sridar V; George Ajish D; Baroni Timothy E; Blackshear Perry J; Anderson Paul
Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin.
The Journal of biological chemistry 2008;283(17):11689-99.
2008: Bingham April; Mamyrova Gulnara; Rother Kristina I; Oral Elif; Cochran Elaine; Premkumar Ahalya; Kleiner David; James-Newton Laura; Targoff Ira N; Pandey Janardan P; Carrick Danielle Mercatante; Sebring Nancy; O'Hanlon Terrance P; Ruiz-Hidalgo Maria; Turner Maria; Gordon Leslie B; Laborda Jorge; Bauer Steven R; Blackshear Perry J; Imundo Lisa; Miller Frederick W; Rider Lisa G;
Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity.
Medicine 2008;87(2):70-86.
2008: Zhang Donghui; Harry G Jean; Blackshear Perry J; Zeldin Darryl C
G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.
The Journal of biological chemistry 2008;283(13):8580-90.
2008: Chulada Patricia C; Vahdat Heather L; Sharp Richard R; DeLozier Tracy C; Watkins Paul B; Pusek Susan N; Blackshear Perry J
The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci.
Human genetics 2008;123(2):207-14.
2008: Cuthbertson Brandon J; Liao Yanhong; Birnbaumer Lutz; Blackshear Perry J
Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe.
The Journal of biological chemistry 2008;283(5):2586-94.
2008: Cuthbertson Brandon J; Blackshear Perry J
Chapter 4. Evaluating the control of mRNA decay in fission yeast.
Methods in enzymology 2008;449():73-95.
2008: Cuthbertson Brandon J; Deterding Leesa J; Williams Jason G; Tomer Kenneth B; Etienne Kizee; Blackshear Perry J; Büllesbach Erika E; Gross Paul S
Diversity in penaeidin antimicrobial peptide form and function.
Developmental and comparative immunology 2008;32(3):167-81.
2007: Cao Heping; Deterding Leesa J; Blackshear Perry J
Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin.
Expert review of proteomics 2007;4(6):711-26.
2007: Zhang Donghui; Zeldin Darryl C; Blackshear Perry J
Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease.
Journal of neuroscience research 2007;85(16):3515-22.
2007: Frasca Daniela; Landin Ana Marie; Alvarez Juan P; Blackshear Perry J; Riley Richard L; Blomberg Bonnie B
Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):918-27.
2007: Carrick Danielle M; Blackshear Perry J
Comparative expression of tristetraprolin (TTP) family member transcripts in normal human tissues and cancer cell lines.
Archives of biochemistry and biophysics 2007;462(2):278-85.
2007: Ehlting Christian; Lai Wi S; Schaper Fred; Brenndörfer Erwin D; Matthes Raphaela-Jessica; Heinrich Peter C; Ludwig Stephan; Blackshear Perry J; Gaestel Matthias; Häussinger Dieter; Bode Johannes G
Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2813-26.
2007: Sharma Sudha; Stumpo Deborah J; Balajee Adayabalam S; Bock Cheryl B; Lansdorp Peter M; Brosh Robert M; Blackshear Perry J
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.
Molecular and cellular biology 2007;27(5):1784-94.
2006: Chulada Patricia C; Corey Linda A; Vannappagari Vani; Whitehead Nedra S; Blackshear Perry J
The feasibility of creating a population-based national twin registry in the United States.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2006;9(6):919-26.
2006: Lai Wi S; Parker Joel S; Grissom Sherry F; Stumpo Deborah J; Blackshear Perry J
Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts.
Molecular and cellular biology 2006;26(24):9196-208.
2006: Brewer Brandy Y; Ballin Jeff D; Fialcowitz-White Elizabeth J; Blackshear Perry J; Wilson Gerald M
Substrate dependence of conformational changes in the RNA-binding domain of tristetraprolin assessed by fluorescence spectroscopy of tryptophan mutants.
Biochemistry 2006;45(46):13807-17.
2006: Alexopoulou Lena; Kranidioti Ksanthi; Xanthoulea Sofia; Denis Maria; Kotanidou Anastasia; Douni Eleni; Blackshear Perry J; Kontoyiannis Dimitris L; Kollias George
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.
European journal of immunology 2006;36(10):2768-80.
2006: Zhang Donghui; Stumpo Deborah J; Graves Joan P; DeGraff Laura M; Grissom Sherry F; Collins Jennifer B; Li Leping; Zeldin Darryl C; Blackshear Perry J
Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.
Journal of neurochemistry 2006;98(3):860-75.
2006: Eun Su Yong; Kim Eun Hae; Kang Kee Seok; Kim Hwa Jung; Jo Sangmee Ahn; Kim Soon Jong; Jo Su Hyun; Kim Sang Jeong; Blackshear Perry J; Kim Jun
Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures.
Experimental & molecular medicine 2006;38(3):310-9.
2006: Sauer Ines; Schaljo Barbara; Vogl Claus; Gattermeier Irene; Kolbe Thomas; Müller Mathias; Blackshear Perry J; Kovarik Pavel
Interferons limit inflammatory responses by induction of tristetraprolin.
Blood 2006;107(12):4790-7.
2006: Carrick Danielle Mercatante; Chulada Patricia; Donn Rachelle; Fabris Martina; McNicholl Janet; Whitworth William; Blackshear Perry J
Genetic variations in ZFP36 and their possible relationship to autoimmune diseases.
Journal of autoimmunity 2006;26(3):182-96.
2006: O'Hanlon Terrance P; Carrick Danielle Mercatante; Targoff Ira N; Arnett Frank C; Reveille John D; Carrington Mary; Gao Xiaojiang; Oddis Chester V; Morel Penelope A; Malley James D; Malley Karen; Shamim Ejaz A; Rider Lisa G; Chanock Stephen J; Foster Charles B; Bunch Thomas; Blackshear Perry J; Plotz Paul H; Love Lori A; Miller Frederick W
Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.
Medicine 2006;85(2):111-27.
2006: Hitti Edward; Iakovleva Tatiana; Brook Matthew; Deppenmeier Stefanie; Gruber Achim D; Radzioch Danuta; Clark Andrew R; Blackshear Perry J; Kotlyarov Alexey; Gaestel Matthias
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.
Molecular and cellular biology 2006;26(6):2399-407.
2006: Cao Heping; Deterding Leesa J; Venable John D; Kennington Elizabeth A; Yates John R; Tomer Kenneth B; Blackshear Perry J
Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis.
The Biochemical journal 2006;394(Pt 1):285-97.
2006: Dunnick J; Blackshear P; Kissling G; Cunningham M; Parker J; Nyska A
Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats.
Toxicologic pathology 2006;34(4):348-56.
2006: Hussain Rifat J; Stumpo Deborah J; Blackshear Perry J; Lenox Robert H; Abel Ted; McNamara Robert K
Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation.
Hippocampus 2006;16(5):495-503.
2005: Lai Wi S; Carrick Danielle M; Blackshear Perry J
Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover.
The Journal of biological chemistry 2005;280(40):34365-77.
2005: Katsanou Vicky; Papadaki Olympia; Milatos Stavros; Blackshear Perry J; Anderson Paul; Kollias George; Kontoyiannis Dimitris L
HuR as a negative posttranscriptional modulator in inflammation.
Molecular cell 2005;19(6):777-89.
2005: Blackshear Perry J; Phillips Ruth S; Ghosh Sanjukta; Ramos Silvia B V; Richfield Eric K; Lai Wi S
Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins.
Biology of reproduction 2005;73(2):297-307.
2005: Li Jing; O'Connor Kathleen L; Greeley George H; Blackshear Perry J; Townsend Courtney M; Evers B Mark
Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.
The Journal of biological chemistry 2005;280(9):8351-7.
2005: Ogilvie Rachel L; Abelson Michelle; Hau Heidi H; Vlasova Irina; Blackshear Perry J; Bohjanen Paul R
Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):953-61.
2005: McNamara Robert K; Hussain Rifat J; Simon Erica J; Stumpo Deborah J; Blackshear Perry J; Abel Ted; Lenox Robert H
Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice.
Hippocampus 2005;15(5):675-83.
2004: Ramos Silvia B V; Stumpo Deborah J; Kennington Elizabeth A; Phillips Ruth S; Bock Cheryl B; Ribeiro-Neto Fernando; Blackshear Perry J
The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development.
Development (Cambridge, England) 2004;131(19):4883-93.
2004: Cosson Bertrand; Braun Frederique; Paillard Luc; Blackshear Perry; Beverley Osborne H
Identification of a novel Xenopus laevis poly (A) binding protein.
Biology of the cell / under the auspices of the European Cell Biology Organization 2004;96(7):519-27.
2004: Stumpo Deborah J; Byrd Noah A; Phillips Ruth S; Ghosh Sanjukta; Maronpot Robert R; Castranio Trisha; Meyers Erik N; Mishina Yuji; Blackshear Perry J
Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.
Molecular and cellular biology 2004;24(14):6445-55.
2004: Brewer Brandy Y; Malicka Joanna; Blackshear Perry J; Wilson Gerald M
RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs.
The Journal of biological chemistry 2004;279(27):27870-7.
2004: Cao Heping; Tuttle Jane S; Blackshear Perry J
Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein.
The Journal of biological chemistry 2004;279(20):21489-99.
2004: Phillips Kristine; Kedersha Nancy; Shen Lily; Blackshear Perry J; Anderson Paul
Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2011-6.
2004: Carrick Danielle M; Lai Wi S; Blackshear Perry J
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.
Arthritis research & therapy 2004;6(6):248-64.
2003: Twizere Jean-Claude; Kruys Véronique; Lefèbvre Laurent; Vanderplasschen Alain; Collete Delphine; Debacq Christophe; Lai Wi S; Jauniaux Jean-Claude; Bernstein Lori R; Semmes O John; Burny Arsène; Blackshear Perry J; Kettmann Richard; Willems Luc
Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Journal of the National Cancer Institute 2003;95(24):1846-59.
2003: Blackshear Perry J; Graves Joan P; Stumpo Deborah J; Cobos Inma; Rubenstein John L R; Zeldin Darryl C
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.
Development (Cambridge, England) 2003;130(19):4539-52.
2003: Scarlett Cameron O; Blackshear Perry J
Neuroanatomical development in the absence of PKC phosphorylation of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein.
Brain research. Developmental brain research 2003;144(1):25-42.
2003: Lai Wi S; Kennington Elizabeth A; Blackshear Perry J
Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.
Molecular and cellular biology 2003;23(11):3798-812.
2003: Blackshear Perry J; Lai Wi S; Kennington Elizabeth A; Brewer Gary; Wilson Gerald M; Guan Xiaoju; Zhou Pei
Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates.
The Journal of biological chemistry 2003;278(22):19947-55.
2003: Cao Heping; Dzineku Frederick; Blackshear Perry J
Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases.
Archives of biochemistry and biophysics 2003;412(1):106-20.
2003: Blackshear Perry J; Phillips Ruth S; Vazquez-Matias Johana; Mohrenweiser Harvey
Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins.
Progress in nucleic acid research and molecular biology 2003;75():43-68.
2002: Blackshear P J
Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover.
Biochemical Society transactions 2002;30(Pt 6):945-52.
2002: Baumgarten Georg; Knuefermann Pascal; Kalra Dinesh; Gao Feng; Taffet George E; Michael Lloyd; Blackshear Perry J; Carballo Ester; Sivasubramanian Natarajan; Mann Douglas L
Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart.
Circulation 2002;105(18):2192-7.
2002: Stein Paula; Svoboda Petr; Stumpo Deborah J; Blackshear Perry J; Lombard David B; Johnson Brad; Schultz Richard M
Analysis of the role of RecQ helicases in RNAi in mammals.
Biochemical and biophysical research communications 2002;291(5):1119-22.
2002: Phillips Ruth S; Ramos Silvia B V; Blackshear Perry J
Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling.
The Journal of biological chemistry 2002;277(13):11606-13.
2002: Lai Wi S; Kennington Elizabeth A; Blackshear Perry J
Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs.
The Journal of biological chemistry 2002;277(11):9606-13.
2001: Carballo E; Cao H; Lai W S; Kennington E A; Campbell D; Blackshear P J
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway.
The Journal of biological chemistry 2001;276(45):42580-7.
2001: Carballo E; Blackshear P J
Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome.
Blood 2001;98(8):2389-95.
2001: Spizz G; Blackshear P J
Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components.
The Journal of biological chemistry 2001;276(34):32264-73.
2001: Kontoyiannis D; Kotlyarov A; Carballo E; Alexopoulou L; Blackshear P J; Gaestel M; Davis R; Flavell R; Kollias G
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.
The EMBO journal 2001;20(14):3760-70.
2001: Lai W S; Blackshear P J
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail.
The Journal of biological chemistry 2001;276(25):23144-54.
2001: Blackshear P J; Lai W S; Thorn J M; Kennington E A; Staffa N G; Moore D T; Bouffard G G; Beckstrom-Sternberg S M; Touchman J W; Bonaldo M F; Soares M B
The NIEHS Xenopus maternal EST project: interim analysis of the first 13,879 ESTs from unfertilized eggs.
Gene 2001;267(1):71-87.
2000: Lai W S; Carballo E; Thorn J M; Kennington E A; Blackshear P J
Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA.
The Journal of biological chemistry 2000;275(23):17827-37.
2000: Carballo E; Lai W S; Blackshear P J
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.
Blood 2000;95(6):1891-9.
1999: Carballo E; Pitterle D M; Stumpo D J; Sperling R T; Blackshear P J
Phagocytic and macropinocytic activity in MARCKS-deficient macrophages and fibroblasts.
The American journal of physiology 1999;277(1 Pt 1):C163-73.
1999: Lai W S; Carballo E; Strum J R; Kennington E A; Phillips R S; Blackshear P J
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.
Molecular and cellular biology 1999;19(6):4311-23.
1999: De J; Lai W S; Thorn J M; Goldsworthy S M; Liu X; Blackwell T K; Blackshear P J
Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression.
Gene 1999;228(1-2):133-45.
1999: Pitterle D M; Sperling R T; Myers M G; White M F; Blackshear P J
Early biochemical events in insulin-stimulated fluid phase endocytosis.
The American journal of physiology 1999;276(1 Pt 1):E94-E105.
1998: McNamara R K; Stumpo D J; Morel L M; Lewis M H; Wakeland E K; Blackshear P J; Lenox R H
Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14517-22.
1998: Topham M K; Bunting M; Zimmerman G A; McIntyre T M; Blackshear P J; Prescott S M
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
Nature 1998;394(6694):697-700.
1998: Kim H S; Swierczynski S L; Tuttle J S; Lai W S; Blackshear P J
Transgenic complementation of MARCKS deficiency with a nonmyristoylatable, pseudo-phosphorylated form of MARCKS: evidence for simultaneous positive and dominant-negative effects on central nervous system development.
Developmental biology 1998;200(2):146-57.
1998: Carballo E; Lai W S; Blackshear P J
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.
Science (New York, N.Y.) 1998;281(5379):1001-5.
1998: Stumpo D J; Eddy R L; Haley L L; Sait S; Shows T B; Lai W S; Young W S; Speer M C; Dehejia A; Polymeropoulos M; Blackshear P J
Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects.
Genomics 1998;49(2):253-64.
1998: Lai W S; Thompson M J; Blackshear P J
Characteristics of the intron involvement in the mitogen-induced expression of Zfp-36.
The Journal of biological chemistry 1998;273(1):506-17.
1997: Blackshear P J; Stumpo D J; Carballo E; Lawrence J C
Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.
The Journal of biological chemistry 1997;272(50):31510-4.
1997: Shi Y; Sullivan S K; Pitterle D M; Kennington E A; Graff J M; Blackshear P J
Mechanisms of MARCKS gene activation during Xenopus development.
The Journal of biological chemistry 1997;272(46):29290-300.
1997: Spizz G; Blackshear P J
Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme.
The Journal of biological chemistry 1997;272(38):23833-42.
1997: Carballo E; Gilkeson G S; Blackshear P J
Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction.
The Journal of clinical investigation 1997;100(5):986-95.
1997: Blackshear P J; Silver J; Nairn A C; Sulik K K; Squier M V; Stumpo D J; Tuttle J S
Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.
Experimental neurology 1997;145(1):46-61.
1997: Chuprun J K; Raymond J R; Blackshear P J
The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts.
The Journal of biological chemistry 1997;272(2):773-81.
1997: Bruccoleri A; Gallucci R; Germolec D R; Blackshear P; Simeonova P; Thurman R G; Luster M I
Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity.
Hepatology (Baltimore, Md.) 1997;25(1):133-41.
1997: Porumb T; Crivici A; Blackshear P J; Ikura M
Calcium binding and conformational properties of calmodulin complexed with peptides derived from myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP).
European biophysics journal : EBJ 1997;25(4):239-47.
1996: Blackshear P J; Lai W S; Tuttle J S; Stumpo D J; Kennington E; Nairn A C; Sulik K K
Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency.
Brain research. Developmental brain research 1996;96(1-2):62-75.
1996: Thompson M J; Lai W S; Taylor G A; Blackshear P J
Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.
Gene 1996;174(2):225-33.
1996: Swierczynski S L; Siddhanti S R; Tuttle J S; Blackshear P J
Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice.
Developmental biology 1996;179(1):135-47.
1996: Swierczynski S L; Blackshear P J
Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine-rich protein kinase C substrate protein in intact cells.
The Journal of biological chemistry 1996;271(38):23424-30.
1996: Taylor G A; Carballo E; Lee D M; Lai W S; Thompson M J; Patel D D; Schenkman D I; Gilkeson G S; Broxmeyer H E; Haynes B F; Blackshear P J
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.
Immunity 1996;4(5):445-54.
1996: Carballo E; Colomer D; Vives-Corrons J L; Blackshear P J; Gil J
Characterization and purification of a protein kinase C substrate in human B cells. Identification as lymphocyte-specific protein 1 (LSP1).
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1709-13.
1996: Taylor G A; Thompson M J; Lai W S; Blackshear P J
Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor.
Molecular endocrinology (Baltimore, Md.) 1996;10(2):140-6.
1996: Cabell C H; Verghese G M; Rankl N B; Burns D J; Blackshear P J
MARCKS phosphorylation by individual protein kinase C isozymes in insect Sf9 cells.
Proceedings of the Association of American Physicians 1996;108(1):37-46.
1996: Spizz G; Blackshear P J
Protein kinase C-mediated phosphorylation of the myristoylated alanine-rich C-kinase substrate protects it from specific proteolytic cleavage.
The Journal of biological chemistry 1996;271(1):553-62.
1995: Lai W S; Thompson M J; Taylor G A; Liu Y; Blackshear P J
Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.
The Journal of biological chemistry 1995;270(42):25266-72.
1995: Lin T A; Kong X; Saltiel A R; Blackshear P J; Lawrence J C
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.
The Journal of biological chemistry 1995;270(31):18531-8.
1995: Swierczynski S L; Blackshear P J
Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein. Mutational analysis provides evidence for complex interactions.
The Journal of biological chemistry 1995;270(22):13436-45.
1995: Taylor G A; Thompson M J; Lai W S; Blackshear P J
Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.
The Journal of biological chemistry 1995;270(22):13341-7.
1995: Carballo E; Colomer D; Vives Corrons J L; Blackshear P J; Gil J
Phosphorylation of the MARCKS family of protein kinase C substrates in human B chronic lymphocytic leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(5):834-9.
1995: Puranam K L; Kennington E; Sait S N; Shows T B; Rochelle J M; Seldin M F; Blackshear P J
Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.
Genomics 1995;26(3):595-8.
1995: Taylor G A; Blackshear P J
Zinc inhibits turnover of labile mRNAs in intact cells.
Journal of cellular physiology 1995;162(3):378-87.
1995: Stumpo D J; Bock C B; Tuttle J S; Blackshear P J
MARCKS deficiency in mice leads to abnormal brain development and perinatal death.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):944-8.
1994: Puranam K L; Blackshear P J
Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.
The Journal of biological chemistry 1994;269(47):29838-45.
1994: Stumpo D J; Haupt D M; Blackshear P J
Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.
The Journal of biological chemistry 1994;269(33):21184-90.
1994: Thompson M J; Roe M W; Malik R K; Blackshear P J
Insulin and other growth factors induce binding of the ternary complex and a novel protein complex to the c-fos serum response element.
The Journal of biological chemistry 1994;269(33):21127-35.
1994: Kim J; Blackshear P J; Johnson J D; McLaughlin S
Phosphorylation reverses the membrane association of peptides that correspond to the basic domains of MARCKS and neuromodulin.
Biophysical journal 1994;67(1):227-37.
1994: Verghese G M; Johnson J D; Vasulka C; Haupt D M; Stumpo D J; Blackshear P J
Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein.
The Journal of biological chemistry 1994;269(12):9361-7.
1993: Clarke P R; Siddhanti S R; Cohen P; Blackshear P J
Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate.
FEBS letters 1993;336(1):37-42.
1993: Lobach D F; Rochelle J M; Watson M L; Seldin M F; Blackshear P J
Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences.
Genomics 1993;17(1):194-204.
1993: Wojtaszek P A; Stumpo D J; Blackshear P J; Macara I G
Severely decreased MARCKS expression correlates with ras reversion but not with mitogenic responsiveness.
Oncogene 1993;8(3):755-60.
1993: Hinrichsen R D; Blackshear P J
Regulation of peptide-calmodulin complexes by protein kinase C in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1585-9.
1993: Blackshear P J
The MARCKS family of cellular protein kinase C substrates.
The Journal of biological chemistry 1993;268(3):1501-4.
1992: George D J; Blackshear P J
Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor.
The Journal of biological chemistry 1992;267(34):24879-85.
1992: Blackshear P J; Tuttle J S; Oakey R J; Seldin M F; Chery M; Philippe C; Stumpo D J
Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein.
Genomics 1992;14(1):168-74.
1992: Blackshear P J
Early protein kinase and biosynthetic responses to insulin.
Biochemical Society transactions 1992;20(3):682-5.
1992: Blackshear P J; Verghese G M; Johnson J D; Haupt D M; Stumpo D J
Characteristics of the F52 protein, a MARCKS homologue.
The Journal of biological chemistry 1992;267(19):13540-6.
1992: Manzella J M; Blackshear P J
Specific protein binding to a conserved region of the ornithine decarboxylase mRNA 5'-untranslated region.
The Journal of biological chemistry 1992;267(10):7077-82.
1992: Lee R M; Cobb M H; Blackshear P J
Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases.
The Journal of biological chemistry 1992;267(2):1088-92.
1991: Harlan D M; Graff J M; Stumpo D J; Eddy R L; Shows T B; Boyle J M; Blackshear P J
The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization.
The Journal of biological chemistry 1991;266(22):14399-405.
1991: Graff J M; Rajan R R; Randall R R; Nairn A C; Blackshear P J
Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain.
The Journal of biological chemistry 1991;266(22):14390-8.
1991: Taylor G A; Lai W S; Oakey R J; Seldin M F; Shows T B; Eddy R L; Blackshear P J
The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes.
Nucleic acids research 1991;19(12):3454.
1991: Blackshear P J; Haupt D M; Stumpo D J
Insulin activation of protein kinase C: a reassessment.
The Journal of biological chemistry 1991;266(17):10946-52.
1991: Lee R M; Rapp U R; Blackshear P J
Evidence for one or more Raf-1 kinase kinase(s) activated by insulin and polypeptide growth factors.
The Journal of biological chemistry 1991;266(16):10351-7.
1991: Malik R K; Roe M W; Blackshear P J
Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells.
The Journal of biological chemistry 1991;266(13):8576-82.
1991: McIlroy B K; Walters J D; Blackshear P J; Johnson J D
Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin.
The Journal of biological chemistry 1991;266(8):4959-64.
1991: Manzella J M; Rychlik W; Rhoads R E; Hershey J W; Blackshear P J
Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E.
The Journal of biological chemistry 1991;266(4):2383-9.
1991: Stumpo D J; Blackshear P J
Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.
The Journal of biological chemistry 1991;266(1):455-60.
1990: Lobaugh L A; Blackshear P J
Neuropeptide Y stimulation of myosin light chain phosphorylation in cultured aortic smooth muscle cells.
The Journal of biological chemistry 1990;265(30):18393-9.
1990: Lai W S; Stumpo D J; Blackshear P J
Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.
The Journal of biological chemistry 1990;265(27):16556-63.
1990: Manzella J M; Blackshear P J
Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region.
The Journal of biological chemistry 1990;265(20):11817-22.
1990: Blackshear P J; Haupt D M; App H; Rapp U R
Insulin activates the Raf-1 protein kinase.
The Journal of biological chemistry 1990;265(21):12131-4.
1990: Lobaugh L A; Blackshear P J
Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells.
The American journal of physiology 1990;258(5 Pt 1):C913-22.
1990: Levenson R M; Anderson G M; Cohn J A; Blackshear P J
Giant two-dimensional gel electrophoresis: methodological update and comparison with intermediate-format gel systems.
Electrophoresis 1990;11(3):269-79.
1989: Graff J M; Young T N; Johnson J D; Blackshear P J
Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C.
The Journal of biological chemistry 1989;264(36):21818-23.
1989: Graff J M; Stumpo D J; Blackshear P J
Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS).
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1903-6.
1989: Levenson R M; Blackshear P J
Insulin-stimulated protein tyrosine phosphorylation in intact cells evaluated by giant two-dimensional gel electrophoresis.
The Journal of biological chemistry 1989;264(33):19984-93.
1989: Graff J M; Gordon J I; Blackshear P J
Myristoylated and nonmyristoylated forms of a protein are phosphorylated by protein kinase C.
Science (New York, N.Y.) 1989;246(4929):503-6.
1989: Blackshear P J
Converging and diverging pathways in polypeptide hormone action.
Clinical research 1989;37(4):554-63.
1989: Blackshear P J; Roussell A M; Cohen A M; Nathan D M
Basal-rate intravenous insulin infusion compared to conventional insulin treatment in patients with type II diabetes. A prospective crossover trial.
Diabetes care 1989;12(7):455-63.
1989: Levenson R M; Nairn A C; Blackshear P J
Insulin rapidly induces the biosynthesis of elongation factor 2.
The Journal of biological chemistry 1989;264(20):11904-11.
1989: Graff J M; Stumpo D J; Blackshear P J
Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C.
The Journal of biological chemistry 1989;264(20):11912-9.
1989: Stumpo D J; Graff J M; Albert K A; Greengard P; Blackshear P J
Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4012-6.
1989: Stumpo D J; Graff J M; Albert K A; Greengard P; Blackshear P J
Nucleotide sequence of a cDNA for the bovine myristoylated alanine-rich C kinase substrate (MARCKS).
Nucleic acids research 1989;17(10):3987-8.
1989: Wen L; Huang J K; Blackshear P J
Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene.
The Journal of biological chemistry 1989;264(15):9016-21.
1989: Blackshear P J; Haupt D M
Evidence against insulin-stimulated phosphorylation of calmodulin in 3T3-L1 adipocytes.
The Journal of biological chemistry 1989;264(7):3854-8.
1989: Blackshear P J; Manzella J M; Stumpo D J; Wen L; Huang J K; Oyen O; Young W S
High level, cell-specific expression of ornithine decarboxylase transcripts in rat genitourinary tissues.
Molecular endocrinology (Baltimore, Md.) 1989;3(1):68-78.
1989: Blackshear P J
Insulin-stimulated protein biosynthesis as a paradigm of protein kinase C-independent growth factor action.
Clinical research 1989;37(1):15-25.
1989: Blackshear P J; Rohde T D
Implantable infusion pumps for drug delivery in man: theoretical and practical considerations.
Horizons in biochemistry and biophysics 1989;9():293-309.
1988: Blackshear P J; Nairn A C; Kuo J F
Protein kinases 1988: a current perspective.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(14):2957-69.
1988: Blackshear P J
Approaches to the study of protein kinase C involvement in signal transduction.
The American journal of the medical sciences 1988;296(4):231-40.
1988: Stumpo D J; Stewart T N; Gilman M Z; Blackshear P J
Identification of c-fos sequences involved in induction by insulin and phorbol esters.
The Journal of biological chemistry 1988;263(4):1611-4.
1988: Morris P B; Hida T; Blackshear P J; Klintworth G K; Swain J L
Tumor-promoting phorbol esters induce angiogenesis in vivo.
The American journal of physiology 1988;254(2 Pt 1):C318-22.
1987: Wolfman A; Wingrove T G; Blackshear P J; Macara I G
Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.
The Journal of biological chemistry 1987;262(34):16546-52.
1987: Blackshear P J; Stumpo D J; Kennington E A; Tuttle J S; Orth D N; Thompson K L; Hung M C; Rosner M R
Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents.
The Journal of biological chemistry 1987;262(25):12356-64.
1987: Girard P R; Stevens V L; Blackshear P J; Merrill A H; Wood J G; Kuo J F
Immunocytochemical evidence for phorbol ester-induced directional translocations of protein kinase C in HL60, K562, CHO, and E7SKS cells: possible role in differentiation.
Cancer research 1987;47(11):2892-8.
1987: Blackshear P J; Stumpo D J; Huang J K; Nemenoff R A; Spach D H
Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells.
The Journal of biological chemistry 1987;262(16):7774-81.
1987: Halsey D L; Girard P R; Kuo J F; Blackshear P J
Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens.
The Journal of biological chemistry 1987;262(5):2234-43.
1987: Chu D T; Stumpo D J; Blackshear P J; Granner D K
The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):53-9.
1987: Blackshear P J; Nemenoff R A; Hovis J G; Halsey D L; Stumpo D J; Huang J K
Insulin action in normal and protein kinase C-deficient rat hepatoma cells. Effects on protein phosphorylation, protein kinase activities, and ornithine decarboxylase activities and messenger ribonucleic acid levels.
Molecular endocrinology (Baltimore, Md.) 1987;1(1):44-52.
1987: Witters L A; Blackshear P J
Protein kinase C-mediated phosphorylation in intact cells.
Methods in enzymology 1987;141():412-24.
1986: Stumpo D J; Blackshear P J
Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9453-7.
1986: Blackshear P J; Robbins D C; Rohde T D; Langer R S; Moses A C; Massey E H
Insulin replacement: current concepts.
ASAIO transactions / American Society for Artificial Internal Organs 1986;32(2):646-55.
1986: Langer R; Blackshear P J; Chang T M; Klein M D; Schultz J S
Enzyme and drug delivery systems.
ASAIO transactions / American Society for Artificial Internal Organs 1986;32(2):639-45.
1986: Spach D H; Nemenoff R A; Blackshear P J
Protein phosphorylation and protein kinase activities in BC3H-1 myocytes. Differences between the effects of insulin and phorbol esters.
The Journal of biological chemistry 1986;261(27):12750-3.
1986: Axelrod L; Shulman G I; Blackshear P J; Bornstein W; Roussell A M; Aoki T T
Plasma level of 13,14-dihydro-15-keto-PGE2 in patients with diabetic ketoacidosis and in normal fasting subjects.
Diabetes 1986;35(9):1004-10.
1986: Hovis J G; Stumpo D J; Halsey D L; Blackshear P J
Effects of mitogens on ornithine decarboxylase activity and messenger RNA levels in normal and protein kinase C-deficient NIH-3T3 fibroblasts.
The Journal of biological chemistry 1986;261(22):10380-6.
1986: Blackshear P J; Wen L; Glynn B P; Witters L A
Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.
The Journal of biological chemistry 1986;261(3):1459-69.
1986: Blackshear P J; Wen L; Nemenoff R A; Gunsalus J R; Witters L A
Growth factor activation of protein kinase C-dependent and -independent pathways of protein phosphorylation in fibroblasts: relevance to activation of protein kinase C in neuronal tissues.
Progress in brain research 1986;69():183-95.
1985: Blackshear P J; Witters L A; Girard P R; Kuo J F; Quamo S N
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.
The Journal of biological chemistry 1985;260(24):13304-15.
1985: Blackshear P J; Shulman G I; Roussell A M; Nathan D M; Minaker K L; Rowe J W; Robbins D C; Cohen A M
Metabolic response to three years of continuous, basal rate intravenous insulin infusion in type II diabetic patients.
The Journal of clinical endocrinology and metabolism 1985;61(4):753-60.
1985: Bishop R; Martinez R; Weber M J; Blackshear P J; Beatty S; Lim R; Herschman H R
Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.
Molecular and cellular biology 1985;5(9):2231-7.
1985: Blackshear P J; Wigness B D; Roussell A M; Cohen A M
Implantable infusion pumps: practical aspects.
Methods in enzymology 1985;112():530-45.
1985: Blackshear P J
Implantable infusion pumps: clinical applications.
Methods in enzymology 1985;112():520-30.
1984: Blackshear P J; Nemenoff R A; Bonventre J V; Cheung J Y; Avruch J
Hormonal regulation of protein phosphorylation in isolated rat heart cells.
The American journal of physiology 1984;246(5 Pt 1):C439-49.
1984: Nemenoff R A; Kwok Y C; Shulman G I; Blackshear P J; Osathanondh R; Avruch J
Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.
The Journal of biological chemistry 1984;259(8):5058-65.
1984: Blackshear P J; Nemenoff R A; Avruch J
Characteristics of insulin and epidermal growth factor stimulation of receptor autophosphorylation in detergent extracts of rat liver and transplantable rat hepatomas.
Endocrinology 1984;114(1):141-52.
1984: Blackshear P J
Systems for polyacrylamide gel electrophoresis.
Methods in enzymology 1984;104():237-55.
1984: Chute E P; Rupp W M; Rohde T D; Goldenberg F J; Bordewich P H; Hitchcock C R; Blackshear P J; Buchwald H
Continuous single-rate long-term insulin infusion using a totally implantable pump.
Transactions - American Society for Artificial Internal Organs 1984;30():387-9.
1983: Blackshear P J; Rotner H E; Kriauciunas K A; Kahn C R
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus.
Annals of internal medicine 1983;99(2):182-4.
1983: Nemenoff R A; Blackshear P J; Avruch J
Hormonal regulation of protein dephosphorylation. Identification and hormonal regulation of protein phosphatase inhibitor-1 in rat adipose tissue.
The Journal of biological chemistry 1983;258(15):9437-43.
1983: Blackshear P J; Nemenoff R A; Avruch J
Insulin binds to and promotes the phosphorylation of a Mr 210 000 component of its receptor in detergent extracts of rat liver microsomes.
FEBS letters 1983;158(2):243-6.
1983: Blackshear P J; Rohde T D; Palmer J L; Wigness B D; Rupp W M; Buchwald H
Glycerol prevents insulin precipitation and interruption of flow in an implantable insulin infusion pump.
Diabetes care 1983;6(4):387-92.
1983: Blackshear P J; Nemenoff R A; Avruch J
Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes.
The Biochemical journal 1983;214(1):11-9.
1983: Rohde T D; Wigness B D; Rupp W M; Mauer S M; Dorman F D; Chapman R C; Blackshear P J; Buchwald H
Control of glycemia in four routes of insulin administration in diabetic dogs.
Transactions - American Society for Artificial Internal Organs 1983;29():720-3.
1983: Wigness B D; Rupp W M; Rohde T D; Steffes M W; Mauer S M; Dorman F D; Chapman R C; Blackshear P J; Buchwald H
Reduced incidence of hypoglycemia in diabetic dogs receiving intensive insulin therapy by implantable pump.
Transactions - American Society for Artificial Internal Organs 1983;29():496-500.
1983: Rupp W M; Rohde T D; Wigness B D; Blackshear P J; Buchwald H
Clinical experience with insulin-glycerol solution in an implantable pump.
Transactions - American Society for Artificial Internal Organs 1983;29():492-5.
1982: Wigness B D; Mauer S M; Rupp W M; Rohde T D; Steffes M W; Blackshear P J; Rucker R D; Jeraj K; Buchwald H
A double balloon catheter technique for alloxan diabetogenesis in the dog.
Surgery, gynecology & obstetrics 1982;155(6):860-4.
1982: Avruch J; Nemenoff R A; Blackshear P J; Pierce M W; Osathanondh R
Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.
The Journal of biological chemistry 1982;257(24):15162-6.
1982: Rupp W M; McCarthy H B; Rohde T D; Blackshear P J; Goldenberg F J; Buchwald H
Risk of osteoporosis in patients treated with long-term intravenous heparin therapy.
Current surgery 1982;39(6):419-22.
1982: Blackshear P J; Nathan D M; Cohen A M; Hurxthal K; Shulman G I
Implantable insulin infusion devices.
JAMA : the journal of the American Medical Association 1982;248(17):2111.
1982: Avruch J; Alexander M C; Palmer J L; Pierce M W; Nemenoff R A; Blackshear P J; Tipper J P; Witters L A
Role of insulin-stimulated protein phosphorylation in insulin action.
Federation proceedings 1982;41(10):2629-33.
1982: Blackshear P J; Fang L S; Axelrod L
Treatment of severe lactic acidosis with dichloroacetate.
Diabetes care 1982;5(4):391-4.
1982: Rupp W M; Barbosa J J; Blackshear P J; McCarthy H B; Rohde T D; Goldenberg F J; Rublein T G; Dorman F D; Buchwald H
The use of an implantable insulin pump in the treatment of type II diabetes.
The New England journal of medicine 1982;307(5):265-70.
1982: Blackshear P J; Nemenoff R A; Avruch J
Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin.
The Biochemical journal 1982;204(3):817-24.
1982: Steffes M W; Buchwald H; Wigness B D; Groppoli T J; Rupp W M; Rohde T D; Blackshear P J; Mauer S M
Diabetic nephropathy in the uninephrectomized dog: microscopic lesions after one year.
Kidney international 1982;21(5):721-4.
1982: Blackshear P J
Insulin infusion pumps in the treatment of diabetes.
Medical instrumentation 1982;16(1):17-9.
1982: Buchwald H; Rupp W M; Rohde T D; Barbosa J; Wigness B D; Dorman F D; McCarthy H B; Goldenberg F J; Blackshear P J; Varco R L; Steffes M W; Mauer S M
Implantable insulin pump: insulin infusion in animals and man.
Transactions - American Society for Artificial Internal Organs 1982;28():687-90.
1982: Rohde T D; Wigness B D; Dorman F D; Rupp W M; Arlt G J; Steffes M W; Blackshear P J; Tirrell M V; Buchwald H
Glucoregulation in the dog by implantable pump and conventional means.
Transactions - American Society for Artificial Internal Organs 1982;28():249-52.
1981: Buchwald H; Barbosa J; Varco R L; Rohde T D; Rupp W M; Schwartz R A; Goldenberg F J; Blackshear P J
Insulin infusion pump.
Lancet 1981;2(8242):360.
1981: Blackshear P J; Rohde T D; Dorman F D; Buchwald H
An implantable pump for long-term intravascular drug infusion.
Medical instrumentation 1981;15(4):226-8.
1981: Buchwald H; Barbosa J; Varco R L; Rohde T D; Rupp W M; Schwartz R A; Goldenberg F J; Rublein T G; Blackshear P J
Treatment of a type II diabetic by a totally implantable insulin infusion device.
Lancet 1981;1(8232):1233-5.
1981: Agius L; Blackshear P J; Williamson D H
Rates of triacylglycerol entry into the circulation in the lactating rat.
The Biochemical journal 1981;196(2):637-40.
1981: Langer R; Urquhart J; Blackshear P J
Panel conference. Implantable drug delivery systems.
Transactions - American Society for Artificial Internal Organs 1981;27():648-54.
1981: Dorman F D; Rohde T D; Arlt G J; Wigness B D; Prosl F R; Blackshear P J; Buchwald H
A two-phase fluid powered insulin infusion pump with basal-bolus capability which compensates for pressure and temperature variability.
Transactions - American Society for Artificial Internal Organs 1981;27():236-40.
1980: Buchwald H; Rohde T D; Schneider P D; Varco R L; Blackshear P J
Long-term, continuous intravenous heparin administration by an implantable infusion pump in ambulatory patients with recurrent venous thrombosis.
Surgery 1980;88(4):507-16.
1980: Cohen A M; Wood W C; Greenfield A; Waltman A; Dedrick C; Blackshear P J
Transbrachial hepatic arterial chemotherapy using an implanted infusion pump.
Diseases of the colon and rectum 1980;23(4):223-7.
1980: Buchwald H; Grage T B; Vassilopoulos P P; Rohde T D; Varco R L; Blackshear P J
Intraarterial infusion chemotherapy for hepatic carcinoma using a totally implantable infusion pump.
Cancer 1980;45(5):866-9.
1980: Buchwald H; Rohde T D; Dorman F D; Skakoon J G; Wigness B D; Prosl F R; Tucker E M; Rublein T G; Blackshear P J; Varco R L
A totally implantable drug infusion defice: laboratory and clinical experience using a model with single flow rate and new design for modulated insulin infusion.
Diabetes care 1980;3(2):351-8.
1979: Blackshear P J
Implantable drug-delivery systems.
Scientific American 1979;241(6):66-73.
1979: Blackshear P J; Rohde T D; Prosl F; Buchwald H
The implantable infusion pump: a new concept in drug delivery.
Medical progress through technology 1979;6(4):149-61.
1979: Blackshear P J; Rohde T D; Grotting J C; Dorman F D; Perkins P R; Varco R L; Buchwald H
Control of blood glucose in experimental diabetes by means of a totally implantable insulin infusion device.
Diabetes 1979;28(7):634-9.
1978: Perkins P R; Dorman F D; Rohde T D; Blackshear P J; Blackshear P L; Varco R L; Buchwald H
Design and initial testing of a totally implantable transcutaneously controllable insulin delivery device.
Transactions - American Society for Artificial Internal Organs 1978;24():229-31.
1977: Rohde T D; Blackshear P J; Varco R L; Buchwald H
One year of heparin anticoagulation. An ambulatory subject using a totally implantable infusion pump.
Minnesota medicine 1977;60(10):719-22.
1977: Blackshear P J; Rohde T D; Varco R L; Buchwald H
The effect of continuous heparin infusion for one year on serum cholesterol and triglyceride concentrations in the dog.
Atherosclerosis 1977;26(1):23-7.
1977: Rohde T D; Blackshear P J; Varco R L; Buchwald H
Protracted parenteral drug infusion in ambulatory subjects using an implantable infusion pump.
Transactions - American Society for Artificial Internal Organs 1977;23():13-6.
1975: Blackshear P J; Holloway P A; Alberti K G
Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.
The Biochemical journal 1975;150(3):379-87.
1975: Blackshear P J; Rohde T D; Varco R L; Buchwald H
One year of continuous heparinization in the dog using a totally implantable infusion pump.
Surgery, gynecology & obstetrics 1975;141(2):176-86.
1975: Blackshear P J
Letter: British health care.
The New England journal of medicine 1975;292(25):1357-8.
1975: Blackshear P J; Holloway P A; Aberti K G
The effects of inhibition of gluconeogenesis on ketogenesis in starved and diabetic rats.
The Biochemical journal 1975;148(3):353-62.
1975: Blackshear P J; Alberti KGMM
Sequential amino acid measurements during experimental diabetic ketoacidosis.
The American journal of physiology 1975;228(1):205-11.
1974: Blackshear P J; Holloway P A; Alberti K G
The effects of starvation and insulin on the release of gluconeogenic substrates from the extra-splanchnic tissues in vivo.
FEBS letters 1974;48(2):310-3.
1974: Blackshear P J; Holloway P A; Alberti K G
The metabolic effects of sodium dichloroacetate in the starved rat.
The Biochemical journal 1974;142(2):279-86.
1974: Blackshear P J; Alberti K G
Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic rat.
The Biochemical journal 1974;138(1):107-17.
1972: Blackshear P J; Dorman F D; Blackshear P L; Varco R L; Buchwald H
The design and initial testing of an implantable infusion pump.
Surgery, gynecology & obstetrics 1972;134(1):51-6.
1970: Blackshear P J; Dorman F D; Blackshear P L; Varco R L; Buchwald H
A permanently implantable self-recycling low flow constant rate multipurpose infusion pump of simple design.
Surgical forum 1970;21():136-7.

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