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George Kunos

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Pál Pacher; George Kunos
Modulating the endocannabinoid system in human health and disease - successes and failures.
Stefan Engeli; Judith Harvey-White; Sandor Batkai; Matthias Blüher; Andrea Bosse-Henck; Reiner Jumpertz; George Kunos; Pal Pacher; Michael Stumvoll; Tobias Wiesner; Hubertus Wirtz; Jens Jordan
Circulating anandamide and blood pressure in patients with obstructive sleep apnea.
Joseph Tam; Daniel Wesley; Jeih-San Liow; Jie Liu; John F McElroy; Bani Mukhopadhyay; Kenner C Rice; Gergő Szanda; Lee Chedester; Kejun Cheng; Robert J Chorvat; Resat Cinar; Jeffrey R Deschamps; Grzegorz Godlewski; Robert B Innis; Tony Jourdan; George Kunos
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.

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All Publications

2013: Pál Pacher; George Kunos
Modulating the endocannabinoid system in human health and disease - successes and failures.
The FEBS journal 2013;280(9):1918-43.
2012: Stefan Engeli; Judith Harvey-White; Sandor Batkai; Matthias Blüher; Andrea Bosse-Henck; Reiner Jumpertz; George Kunos; Pal Pacher; Michael Stumvoll; Tobias Wiesner; Hubertus Wirtz; Jens Jordan
Circulating anandamide and blood pressure in patients with obstructive sleep apnea.
Journal of hypertension 2012;30(12):2345-51.
2012: Joseph Tam; Daniel Wesley; Jeih-San Liow; Jie Liu; John F McElroy; Bani Mukhopadhyay; Kenner C Rice; Gergő Szanda; Lee Chedester; Kejun Cheng; Robert J Chorvat; Resat Cinar; Jeffrey R Deschamps; Grzegorz Godlewski; Robert B Innis; Tony Jourdan; George Kunos
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.
Cell metabolism 2012;16(2):167-79.
2012: Jie Liu; Bani Mukhopadhyay; James O'Hare; James Pickel; Thomas Scherer; Xin Shan; Joseph Tam; Keming Xiong; Shi Yin; Liang Zhou; Ramon Bataller; Christoph Buettner; Peter Gao; Grzegorz Godlewski; George Kunos
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice.
Gastroenterology 2012;142(5):1218-1228.e1.
2011: George Kunos; Joseph Tam
The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications.
British journal of pharmacology 2011;163(7):1423-31.
2011: Markus Heilig; Kenneth R Warren; George Kunos; Peter B Silverman; Brenda G Hewitt
Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism.
Addiction (Abingdon, England) 2011;106(6):1052-60.
2011: Bani Mukhopadhyay; Resat Cinar; Shi Yin; Jie Liu; Joseph Tam; Grzegorz Godlewski; Judith Harvey-White; Isioma Mordi; Benjamin F Cravatt; Sophie Lotersztajn; Bin Gao; Qiaoping Yuan; Kornel E Schuebel; David Goldman; George Kunos
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6323-8.
2011: Joseph Tam; Jie Liu; Bani Mukhopadhyay; Resat Cinar; Grzegorz Godlewski; George Kunos
Endocannabinoids in liver disease.
Hepatology (Baltimore, Md.) 2011;53(1):346-55.
2011: Panayotis K Thanos; Vanessa Gopez; Foteini Delis; Michael Michaelides; David K Grandy; Gene-Jack Wang; George Kunos; Nora D Volkow
Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.
Alcoholism, clinical and experimental research 2011;35(1):19-27.
2010: Grzegorz Godlewski; Shakiru O Alapafuja; Sandor Batkai; Spyros P Nikas; Resat Cinar; László Offertáler; Douglas Osei-Hyiaman; Jie Liu; Bani Mukhopadhyay; Judith Harvey-White; Joseph Tam; Karel Pacak; Jacqueline L Blankman; Benjamin F Cravatt; Alexandros Makriyannis; George Kunos
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Chemistry & biology 2010;17(11):1256-66.
2010: Joseph Tam; V Kiran Vemuri; Jie Liu; Sándor Bátkai; Bani Mukhopadhyay; Grzegorz Godlewski; Douglas Osei-Hyiaman; Shinobu Ohnuma; Suresh V Ambudkar; James Pickel; Alexandros Makriyannis; George Kunos
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.
The Journal of clinical investigation 2010;120(8):2953-66.
2010: Bani Mukhopadhyay; Jie Liu; Douglas Osei-Hyiaman; Grzegorz Godlewski; Partha Mukhopadhyay; Lei Wang; Won-Il Jeong; Bin Gao; Gregg Duester; Ken Mackie; Soichi Kojima; George Kunos
Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.
The Journal of biological chemistry 2010;285(25):19002-11.
2010: Andrew M Miller; Hua Wang; Ogyi Park; Norio Horiguchi; Fouad Lafdil; Partha Mukhopadhyay; Akira Moh; Xin Yuan Fu; George Kunos; Pal Pacher; Bin Gao
Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury.
Alcoholism, clinical and experimental research 2010;34(4):719-25.
2010: Hua Wang; Ogyi Park; Fouad Lafdil; Kezhen Shen; Norio Horiguchi; Shi Yin; Xin-Yuan Fu; George Kunos; Bin Gao
Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity.
Hepatology (Baltimore, Md.) 2010;51(4):1354-62.
2010: David T George; David W Herion; Cheryl L Jones; Monte J Phillips; Jacqueline Hersh; Debra Hill; Markus Heilig; Vijay A Ramchandani; Christopher Geyer; David E Spero; Erick D Singley; Stephanie S O'Malley; Raafat Bishai; Robert R Rawlings; George Kunos
Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers.
Psychopharmacology 2010;208(1):37-44.
2009: Grzegorz Godlewski; László Offertáler; Jens A Wagner; George Kunos
Receptors for acylethanolamides-GPR55 and GPR119.
Prostaglandins & other lipid mediators 2009;89(3-4):105-11.
2009: George Kunos; Douglas Osei-Hyiaman; Sandor Batkai; Keith Sharkey; Alexandros Makriyannis
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
Trends in pharmacological sciences 2009;30(1):1-7.
2009: Grzegorz Godlewski; László Offertáler; Douglas Osei-Hyiaman; Fong Ming Mo; Judith Harvey-White; Jie Liu; Margaret I Davis; Li Zhang; Raj K Razdan; Garry Milman; Pal Pacher; Partha Mukhopadhyay; David M Lovinger; George Kunos
The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.
The Journal of pharmacology and experimental therapeutics 2009;328(1):351-61.
2008: George Kunos
A tribute to Dr. Ting-Kai Li.
Alcoholism, clinical and experimental research 2008;32(12):2030.
2008: George Kunos; Douglas Osei-Hyiaman; Jie Liu; Gregorz Godlewski; Sandor Batkai
Endocannabinoids and the control of energy homeostasis.
The Journal of biological chemistry 2008;283(48):33021-5.
2008: Pál Pacher; Partha Mukhopadhyay; Rajesh Mohanraj; Grzegorz Godlewski; Sandor Batkai; George Kunos
Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations.
Hypertension 2008;52(4):601-7.
2008: Douglas Osei-Hyiaman; Jie Liu; Liang Zhou; Grzegorz Godlewski; Judith Harvey-White; Won-Il Jeong; Sandor Batkai; Giovanni Marsicano; Beat Lutz; Christoph Buettner; George Kunos
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
The Journal of clinical investigation 2008;118(9):3160-9.
2008: Christoph Buettner; Evan D Muse; Andrew Cheng; Linghong Chen; Thomas Scherer; Alessandro Pocai; Kai Su; Bob Cheng; Xiaosong Li; Judith Harvey-White; Gary J Schwartz; George Kunos; Luciano Rossetti; Christoph Buettner
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms.
Nature medicine 2008;14(6):667-75.
2008: Mirjam Christ-Crain; Blerina Kola; Francesca Lolli; Csaba Fekete; Dalma Seboek; Gábor Wittmann; Daniel Feltrin; Susana C Igreja; Sharon Ajodha; Judith Harvey-White; George Kunos; Beat Müller; Francois Pralong; Gregory Aubert; Giorgio Arnaldi; Gilberta Giacchetti; Marco Boscaro; Ashley B Grossman; Marta Korbonits
AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1672-83.
2008: Ana Guijarro; Douglas Osei-Hyiaman; Judith Harvey-White; George Kunos; Susumu Suzuki; Sergiy Nadtochiy; Paul S Brookes; Michael M Meguid
Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function.
Annals of surgery 2008;247(5):779-90.
2008: George Kunos; Douglas Osei-Hyiaman
Endocannabinoids and liver disease. IV. Endocannabinoid involvement in obesity and hepatic steatosis.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(5):G1101-4.
2008: Miklós Palkovits; J Harvey-White; J Liu; Z S Kovacs; M Bobest; Gábor Lovas; Attila Bagó; George Kunos
Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain.
Neuroscience 2008;152(4):1032-9.
2008: Norio Horiguchi; Lei Wang; Partha Mukhopadhyay; Ogyi Park; Won-Il Jeong; Fouad Lafdil; Douglas Osei-Hyiaman; Akira Moh; Xin Yuan Fu; Pal Pacher; George Kunos; Bin Gao
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
Gastroenterology 2008;134(4):1148-58.
2008: Won-Il Jeong; Douglas Osei-Hyiaman; Ogyi Park; Jie Liu; Sandor Batkai; Partha Mukhopadhyay; Norio Horiguchi; Judith Harvey-White; Giovanni Marsicano; Beat Lutz; Bin Gao; George Kunos
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
Cell metabolism 2008;7(3):227-35.
2008: George Kunos; Bin Gao
Endocannabinoids, CB1 receptors, and liver disease: hitting more than one bird with the same stone.
Gastroenterology 2008;134(2):622-5.
2008: Blerina Kola; Imre Farkas; Mirjam Christ-Crain; Gábor Wittmann; Francesca Lolli; Faisal Amin; Judith Harvey-White; Zsolt Liposits; George Kunos; Ashley B Grossman; Csaba Fekete; Marta Korbonits
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
PloS one 2008;3(3):e1797.
2008: Jie Liu; Lei Wang; Judith Harvey-White; Bill X Huang; Hee-Yong Kim; Serge Luquet; Richard D Palmiter; Gerald Krystal; Ravi Rai; Anu Mahadevan; Raj K Razdan; George Kunos
Multiple pathways involved in the biosynthesis of anandamide.
Neuropharmacology 2008;54(1):1-7.
2007: Andrea Telek; Tamás Bíró; Eniko Bodó; Balázs Istvan Tóth; István Borbíró; George Kunos; Ralf Paus
Inhibition of human hair follicle growth by endo- and exocannabinoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3534-41.
2007: George Kunos
Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system?
The American journal of medicine 2007;120(9 Suppl 1):S18-24; discussion S24.
2007: Sandor Batkai; Partha Mukhopadhyay; Judith Harvey-White; Raouf Kechrid; Pal Pacher; George Kunos
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1689-95.
2007: Soeren Siegmund; Ting Qian; Samuele De Minicis; Judith Harvey-White; George Kunos; K Y Vinod; Basalingappa L Hungund; Robert F Schwabe
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2798-806.
2007: Partha Mukhopadhyay; Sandor Batkai; Mohanraj Rajesh; Nora Czifra; Judith Harvey-White; György Haskó; Zsuzsanna Zsengeller; Norma P Gerard; Lucas Liaudet; George Kunos; Pal Pacher
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
Journal of the American College of Cardiology 2007;50(6):528-36.
2007: Xuefeng Zhang; Jian Feng Wang; George Kunos; Jerome E Groopman
Cannabinoid modulation of Kaposi's sarcoma-associated herpesvirus infection and transformation.
Cancer research 2007;67(15):7230-7.
2007: Nitin Agarwal; Pal Pacher; Irmgard Tegeder; Fumimasa Amaya; Cristina E Constantin; Gary Brenner; Tiziana Rubino; Christoph W Michalski; Giovanni Marsicano; Krisztina Monory; Ken Mackie; Claudiu Marian; Sandor Batkai; Daniela Parolaro; Michael J Fischer; Peter W Reeh; George Kunos; Michaela Kress; Beat Lutz; Clifford J Woolf; Rohini Kuner
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Nature neuroscience 2007;10(7):870-9.
2007: Sandor Batkai; Douglas Osei-Hyiaman; Hao Pan; Osama N El-Assal; Mohanraj Rajesh; Partha Mukhopadhyay; Feng Hong; Judith Harvey-White; Anjum Jafri; György Haskó; John W Huffman; Bin Gao; George Kunos; Pal Pacher
Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1788-800.
2007: Anita C Hansson; Francisco Javier Bermúdez-Silva; Hanna Malinen; Petri Hyytiä; Irene Sanchez-Vera; Roberto Rimondini; Fernando Rodriguez de Fonseca; George Kunos; Wolfgang Sommer; Markus Heilig
Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(1):117-26.
2006: Jie Liu; Lei Wang; Judith Harvey-White; Douglas Osei-Hyiaman; Raj K Razdan; Qian Gong; Andrew C Chan; Zhifeng Zhou; Bill X Huang; Hee-Yong Kim; George Kunos
A biosynthetic pathway for anandamide.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13345-50.
2006: Pal Pacher; Sandor Batkai; George Kunos
The endocannabinoid system as an emerging target of pharmacotherapy.
Pharmacological reviews 2006;58(3):389-462.
2006: George Kunos; Douglas Osei-Hyiaman; Sandor Batkai; Bin Gao
Cannabinoids hurt, heal in cirrhosis.
Nature medicine 2006;12(6):608-10.
2006: Douglas Osei-Hyiaman; Judith Harvey-White; Sandor Batkai; George Kunos
The role of the endocannabinoid system in the control of energy homeostasis.
International journal of obesity (2005) 2006;30 Suppl 1():S33-8.
2006: Garry Milman; Yehoshua Maor; Saleh Abu-Lafi; Michal Horowitz; Ruth Gallily; Sandor Batkai; Fong-Ming Mo; Laszlo Offertaler; Pal Pacher; George Kunos; Urij Rampampam
N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2428-33.
2006: Nora D Volkow; Gene-Jack Wang; Dinko Franceschi; Joanna S Fowler; Panayotis Peter K Thanos; Laurence Maynard; S John Gatley; Christopher Wong; Richard L Veech; George Kunos; Ting Kai Li
Low doses of alcohol substantially decrease glucose metabolism in the human brain.
NeuroImage 2006;29(1):295-301.
2005: Pal Pacher; Sandor Batkai; George Kunos
Cirrhotic cardiomyopathy: an endocannabinoid connection?
British journal of pharmacology 2005;146(3):313-4.
2005: Jens A Wagner; Marco Abesser; Jan Karcher; Martin Laser; George Kunos
Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts.
Journal of cardiovascular pharmacology 2005;46(3):348-55.
2005: Pal Pacher; Sandor Batkai; Douglas Osei-Hyiaman; László Offertáler; Jie Liu; Judith Harvey-White; Attila Brassai; Zoltán Járai; Benjamin F Cravatt; George Kunos
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H533-41.
2005: Pal Pacher; Sandor Batkai; George Kunos
Blood pressure regulation by endocannabinoids and their receptors.
Neuropharmacology 2005;48(8):1130-8.
2005: Malcolm Begg; Pal Pacher; Sandor Batkai; Douglas Osei-Hyiaman; László Offertáler; Fong-Ming Mo; Jie Liu; George Kunos
Evidence for novel cannabinoid receptors.
Pharmacology & therapeutics 2005;106(2):133-45.
2005: Douglas Osei-Hyiaman; Michael DePetrillo; Pal Pacher; Jie Liu; Svetlana Radaeva; Sandor Batkai; Judith Harvey-White; Ken Mackie; László Offertáler; Lei Wang; George Kunos
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.
The Journal of clinical investigation 2005;115(5):1298-305.
2005: Pal Pacher; Sandor Batkai; George Kunos
Cardiovascular pharmacology of cannabinoids.
Handbook of experimental pharmacology 2005;(168):599-625.
2005: Douglas Osei-Hyiaman; Michael Depetrillo; Judith Harvey-White; Anthony W Bannon; Benjamin F Cravatt; Michael J Kuhar; Ken Mackie; Miklós Palkovits; George Kunos
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Neuroendocrinology 2005;81(4):273-82.
2004: Sandor Batkai; Pal Pacher; Douglas Osei-Hyiaman; Svetlana Radaeva; Jie Liu; Judith Harvey-White; László Offertáler; Ken Mackie; M Audrey Rudd; Richard D Bukoski; George Kunos
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Circulation 2004;110(14):1996-2002.
2004: Sandor Batkai; Pal Pacher; Zoltán Járai; Jens A Wagner; George Kunos
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H595-600.
2004: Pal Pacher; Sandor Batkai; George Kunos
Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice.
The Journal of physiology 2004;558(Pt 2):647-57.
2004: George Kunos; Pal Pacher
Cannabinoids cool the intestine.
Nature medicine 2004;10(7):678-9.
2004: Fong-Ming Mo; László Offertáler; George Kunos
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.
European journal of pharmacology 2004;489(1-2):21-7.
2003: Malcolm Begg; Fong-Ming Mo; László Offertaler; Sandor Batkai; Pal Pacher; Raj K Razdan; David M Lovinger; George Kunos
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
The Journal of biological chemistry 2003;278(46):46188-94.
2003: Jie Liu; Sandor Batkai; Pal Pacher; Judith Harvey-White; Jens A Wagner; Benjamin F Cravatt; Bin Gao; George Kunos
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor.
The Journal of biological chemistry 2003;278(45):45034-9.
2003: Zhaoli Sun; Andrew S Klein; Svetlana Radaeva; Feng Hong; Osama N El-Assal; Hong-na Pan; Barbara Jaruga; Sandor Batkai; Sumito Hoshino; Zhigang Tian; George Kunos; Anna Mae Diehl; Bin Gao
In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats.
Gastroenterology 2003;125(1):202-15.
2003: László Offertáler; Fong-Ming Mo; Sandor Batkai; Jie Liu; Malcolm Begg; Raj K Razdan; Billy R Martin; Richard D Bukoski; George Kunos
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.
Molecular pharmacology 2003;63(3):699-705.
2003: Lisa Walter; Allyn Franklin; Anke Witting; Christian Wade; Yiheng Xie; George Kunos; Ken Mackie; Nephi Stella
Nonpsychotropic cannabinoid receptors regulate microglial cell migration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(4):1398-405.
2003: Lei Wang; Jie Liu; Judith Harvey-White; Andreas Zimmer; George Kunos
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1393-8.
2002: George Kunos; Sandor Batkai; László Offertáler; Fong-Ming Mo; Jie Liu; Jan Karcher; Judith Harvey-White
The quest for a vascular endothelial cannabinoid receptor.
Chemistry and physics of lipids 2002;121(1-2):45-56.
2002: Jie Liu; Zhigang Tian; Bin Gao; George Kunos
Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells: differential involvement of adenosine.
The Journal of biological chemistry 2002;277(23):20927-33.
2002: Basalingappa L Hungund; Balapal S Basavarajappa; Csaba Vadasz; George Kunos; Fernando Rodriguez de Fonseca; Giancarlo Colombo; Salvatore Serra; Loren Parsons; George F Koob
Ethanol, endocannabinoids, and the cannabinoidergic signaling system.
Alcoholism, clinical and experimental research 2002;26(4):565-74.
2002: Richard D Bukoski; Sandor Batkai; Zoltán Járai; Yanlin Wang; Laszlo Offertaler; William F Jackson; George Kunos
CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice.
Hypertension 2002;39(2):251-7.
2001: Jens A Wagner; Kai Hu; Johann Bauersachs; Jan Karcher; M Wiesler; Sravan K Goparaju; George Kunos; Georg Ertl
Endogenous cannabinoids mediate hypotension after experimental myocardial infarction.
Journal of the American College of Cardiology 2001;38(7):2048-54.
2001: George Kunos; Sandor Batkai
Novel physiologic functions of endocannabinoids as revealed through the use of mutant mice.
Neurochemical research 2001;26(8-9):1015-21.
2001: R I Wilson; George Kunos; Roger A Nicoll
Presynaptic specificity of endocannabinoid signaling in the hippocampus.
Neuron 2001;31(3):453-62.
2001: Jens A Wagner; Zoltán Járai; Sandor Batkai; George Kunos
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.
European journal of pharmacology 2001;423(2-3):203-10.
2001: Sandor Batkai; Zoltán Járai; Jens A Wagner; Sravan K Goparaju; K Varga; Jie Liu; Lei Wang; Faridoddin Mirshahi; A D Khanolkar; A Makriyannis; R Urbaschek; Nelson Garcia; Arun J Sanyal; George Kunos
Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis.
Nature medicine 2001;7(7):827-32.
2001: Vincenzo Di Marzo; Sravan K Goparaju; Lei Wang; Jie Liu; Sandor Batkai; Zoltán Járai; F Fezza; G I Miura; R D Palmiter; T Sugiura; George Kunos
Leptin-regulated endocannabinoids are involved in maintaining food intake.
Nature 2001;410(6830):822-5.
2001: Bin Gao; X Shen; George Kunos; Q Meng; I D Goldberg; E M Rosen; S Fan
Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.
FEBS letters 2001;488(3):179-84.
2001: Nelson Garcia; Zoltán Járai; Faridoddin Mirshahi; George Kunos; Arun J Sanyal
Systemic and portal hemodynamic effects of anandamide.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(1):G14-20.
2000: Feng Hong; Van Anh Nguyen; X Shen; George Kunos; Bin Gao
Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration.
Biochemical and biophysical research communications 2000;279(3):974-9.
2000: George Kunos; Zoltán Járai; Sandor Batkai; Sravan K Goparaju; Edward J N Ishac; Jie Liu; Lei Wang; Jens A Wagner
Endocannabinoids as cardiovascular modulators.
Chemistry and physics of lipids 2000;108(1-2):159-68.
2000: M Spector; Van Anh Nguyen; X Sheng; L He; John J Woodward; S Fan; Clive M Baumgarten; George Kunos; Paul Dent; Bin Gao
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Experimental cell research 2000;258(1):109-20.
2000: Jie Liu; X Shen; Van Anh Nguyen; George Kunos; Bin Gao
Alpha(1) adrenergic agonist induction of p21(waf1/cip1) mRNA stability in transfected HepG2 cells correlates with the increased binding of an AU-rich element binding factor.
The Journal of biological chemistry 2000;275(16):11846-51.
2000: George Kunos; Zoltán Járai; K Varga; Jie Liu; Lei Wang; Jens A Wagner
Cardiovascular effects of endocannabinoids--the plot thickens.
Prostaglandins & other lipid mediators 2000;61(1-2):71-84.
2000: Jie Liu; Bin Gao; Faridoddin Mirshahi; Arun J Sanyal; A D Khanolkar; A Makriyannis; George Kunos
Functional CB1 cannabinoid receptors in human vascular endothelial cells.
The Biochemical journal 2000;346 Pt 3():835-40.
2000: Zoltán Járai; Jens A Wagner; Sravan K Goparaju; Lei Wang; Raj K Razdan; T Sugiura; AM Zimmer; Tom Bonner; Andreas Zimmer; George Kunos
Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice.
Hypertension 2000;35(2):679-84.
2000: Bin Gao; George Kunos
DNase I footprinting analysis of transcription factors recognizing adrenergic receptor gene promoter sequences.
Methods in molecular biology (Clifton, N.J.) 2000;126():419-29.
2000: Bin Gao; George Kunos
Southwestern blots for detection of a DNA binding protein recognizing the alpha 1B-adrenergic receptor gene promoter.
Methods in molecular biology (Clifton, N.J.) 2000;126():411-7.
1999: Zoltán Járai; Jens A Wagner; K Varga; KD Lake; DR Compton; Billy R Martin; AM Zimmer; Tom Bonner; Nancy E Buckley; Eva Mezey; Raj K Razdan; Andreas Zimmer; George Kunos
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):14136-41.
1999: George Kunos
The discovery of endogenous cannabinoids.
Brain research bulletin 1999;50(5-6):359-60.
1999: Jing Chen; George Kunos; Bin Gao
Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes.
FEBS letters 1999;457(1):162-8.
1999: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis; Dominique Melck; Pierangelo Orlando; J A Wagner; George Kunos
Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages.
European journal of biochemistry / FEBS 1999;264(1):258-67.
1999: Jens A Wagner; K Varga; Zoltán Járai; George Kunos
Mesenteric vasodilation mediated by endothelial anandamide receptors.
Hypertension 1999;33(1 Pt 2):429-34.
1998: Bin Gao; George Kunos
Cell type-specific transcriptional activation and suppression of the alpha1B adrenergic receptor gene middle promoter by nuclear factor 1.
The Journal of biological chemistry 1998;273(48):31784-7.
1998: Jens A Wagner; K Varga; George Kunos
Cardiovascular actions of cannabinoids and their generation during shock.
Journal of molecular medicine (Berlin, Germany) 1998;76(12):824-36.
1998: KL Auer; MS Spector; Robert M Tombes; Prem Seth; Paul B Fisher; Bin Gao; Paul Dent; George Kunos
Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway.
FEBS letters 1998;436(1):131-8.
1998: Jing Chen; Edward J N Ishac; Paul Dent; George Kunos; Bin Gao
Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver.
The Biochemical journal 1998;334 ( Pt 3)():669-76.
1998: K Varga; Jens A Wagner; D Troy Bridgen; George Kunos
Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(11):1035-44.
1998: Luis G Aguayo; F Espinoza; George Kunos; Leslie S Satin
Effects of intracellular calcium on GABAA receptors in mouse cortical neurons.
Pflügers Archiv : European journal of physiology 1998;435(3):382-7.
1998: Bin Gao; H Jaffe; George Kunos
Histone H1 isoforms purified from rat liver bind nonspecifically to the nuclear factor 1 recognition sequence and serve as generalized transcriptional repressors.
Molecular and cellular biochemistry 1998;178(1-2):187-96.
1997: Jens A Wagner; K Varga; Earl F Ellis; Beverly A Rzigalinski; Billy R Martin; George Kunos
Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock.
Nature 1997;390(6659):518-21.
1997: Bin Gao; Jing Chen; C Johnson; George Kunos
Both the cyclic AMP response element and the activator protein 2 binding site mediate basal and cyclic AMP-induced transcription from the dominant promoter of the rat alpha 1B-adrenergic receptor gene in DDT1MF-2 cells.
Molecular pharmacology 1997;52(6):1019-26.
1997: Jing Chen; H Bao; S Sawyer; George Kunos; Bin Gao
Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver.
Biochemical and biophysical research communications 1997;239(3):666-9.
1997: Jing Chen; MS Spector; George Kunos; Bin Gao
Sp1-mediated transcriptional activation from the dominant promoter of the rat alpha1B adrenergic receptor gene in DDT1MF-2 cells.
The Journal of biological chemistry 1997;272(37):23144-50.
1997: K Varga; George Kunos
Cardiovascular effects of ethanol in rats selectively bred for high or low sensitivity to the hypnotic effects of ethanol.
Alcoholism, clinical and experimental research 1997;21(6):1024-9.
1997: W David Jarvis; KL Auer; M Spector; George Kunos; Steven Grant; P Hylemon; Ross B Mikkelsen; Paul Dent
Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes.
FEBS letters 1997;412(1):9-14.
1997: MS Spector; KL Auer; W D Jarvis; Edward J N Ishac; Bin Gao; George Kunos; Paul Dent
Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.
Molecular and cellular biology 1997;17(7):3556-65.
1997: KD Lake; DR Compton; K Varga; Billy R Martin; George Kunos
Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1030-7.
1997: KD Lake; Billy R Martin; George Kunos; K Varga
Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats.
Hypertension 1997;29(5):1204-10.
1996: Bin Gao; L Jiang; George Kunos
Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver.
Molecular and cellular biology 1996;16(11):5997-6008.
1996: L Jiang; Bin Gao; George Kunos
DNA elements and protein factors involved in the transcription of the beta 2-adrenergic receptor gene in rat liver. The negative regulatory role of C/EBP alpha.
Biochemistry 1996;35(40):13136-46.
1996: K Varga; K D Lake; D Huangfu; Patrice G Guyenet; George Kunos
Mechanism of the hypotensive action of anandamide in anesthetized rats.
Hypertension 1996;28(4):682-6.
1996: K Varga; Gábor Lovas; Miklós Palkovits; George Kunos
Ethanol inhibition of stress-related tachycardia involves medullary NMDA receptors.
European journal of pharmacology 1996;310(2-3):145-53.
1996: S J Li; K Varga; P Archer; Victor J Hruby; S D Sharma; RA Kesterson; Roger D Cone; George Kunos
Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5182-8.
1996: Edward J N Ishac; L Jiang; K D Lake; K Varga; Mary E Abood; George Kunos
Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves.
British journal of pharmacology 1996;118(8):2023-8.
1996: S J Li; M N Scanlon; Zoltán Járai; K Varga; N S Gantenberg; E Lazar-Wesley; George Kunos
alpha-2-Adrenergic activation of proopiomelanocortin-containing neurons in the arcuate nucleus causes opioid-mediated hypotension and bradycardia.
Neuroendocrinology 1996;63(3):275-83.
1995: L Jiang; George Kunos
Sequence of the 5' regulatory domain of the gene encoding the rat beta 2-adrenergic receptor.
Gene 1995;163(2):331-2.
1995: K Varga; K Lake; Billy R Martin; George Kunos
Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide.
European journal of pharmacology 1995;278(3):279-83.
1995: George Kunos; Edward J N Ishac; Bin Gao; L Jiang
Inverse regulation of hepatic alpha 1B- and beta 2-adrenergic receptors. Cellular mechanisms and physiological implications.
Annals of the New York Academy of Sciences 1995;757():261-71.
1995: Bin Gao; M S Spector; George Kunos
The rat alpha 1B adrenergic receptor gene middle promoter contains multiple binding sites for sequence-specific proteins including a novel ubiquitous transcription factor.
The Journal of biological chemistry 1995;270(10):5614-9.
1995: George Kunos; K Varga
The tachycardia associated with the defense reaction involves activation of both GABAA and GABAB receptors in the nucleus tractus solitarii.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1995;17(1-2):91-100.
1994: Bin Gao; George Kunos
Transcription of the rat alpha 1B adrenergic receptor gene in liver is controlled by three promoters.
The Journal of biological chemistry 1994;269(22):15762-7.
1994: K Varga; N S Gantenberg; George Kunos
Endogenous gamma-aminobutyric acid (GABA) mediates ethanol inhibition of vagally mediated reflex bradycardia elicited from aortic baroreceptors.
The Journal of pharmacology and experimental therapeutics 1994;268(2):1057-62.
1993: S Caneschi; P Cazzaniga; M Errico; George Kunos; A Lorenzi; A L Messina; E Rosa
[Transcranial Doppler assessment of the arterial cerebral circulation during anesthesiologic induction in neurosurgery].
Minerva anestesiologica 1993;59(12):737-43.
1993: B Gao; George Kunos
Isolation and characterization of the gene encoding the rat alpha 1B adrenergic receptor.
Gene 1993;131(2):243-7.
1993: B Gao; M Virmani; E Romm; E Lazar-Wesley; K Sakaguchi; E Appella; George Kunos; L Takács
Sequence of a cDNA encoding bovine apolipoprotein H.
Gene 1993;126(2):287-8.
1992: M N Scanlon; E Lazar-Wesley; Kathleen A Grant; George Kunos
Proopiomelanocortin messenger RNA is decreased in the mediobasal hypothalamus of rats made dependent on ethanol.
Alcoholism, clinical and experimental research 1992;16(6):1147-51.
1992: T Szentendrei; E Lazar-Wesley; T Nakane; M Virmani; George Kunos
Selective regulation of beta 2-adrenergic receptor gene expression by interleukin-1 in cultured human lung tumor cells.
Journal of cellular physiology 1992;152(3):478-85.
1992: M N Scanlon; E Lazar-Wesley; T Csikos; George Kunos
Rat hypothalamic proopiomelanocortin messenger RNA is unaffected by adrenalectomy.
Biochemical and biophysical research communications 1992;186(1):418-25.
1992: Edward J N Ishac; E Lazar-Wesley; George Kunos
Rapid inverse changes in alpha 1B- and beta 2-adrenergic receptors and gene transcripts in acutely isolated rat liver cells.
Journal of cellular physiology 1992;152(1):79-86.
1992: K Varga; George Kunos
Inhibition of baroreflex bradycardia by ethanol involves both GABAA and GABAB receptors in the brainstem of the rat.
European journal of pharmacology 1992;214(2-3):223-32.
1992: E Dora; K Hines; George Kunos; Alan C McLaughlin
Significance of an opiate mechanism in the adjustment of cerebrocortical oxygen consumption and blood flow during hypercapnic stress.
Brain research 1992;573(2):293-8.
1991: S Caneschi; P Cazzaniga; M Errico; George Kunos; A Lorenzi; A L Messina; E Rosa
[Non-invasive monitoring of hemodynamic parameters during anesthesia induction].
Minerva anestesiologica 1991;57(10):1006-7.
1991: E Lazar-Wesley; J R Hadcock; C C Malbon; George Kunos; Edward J N Ishac
Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat.
Endocrinology 1991;129(2):1116-8.
1990: A Florentino; K Varga; George Kunos
Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.
Brain research 1990;535(2):264-70.
1990: K Varga; George Kunos
Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.
British journal of pharmacology 1990;101(4):773-5.
1990: M S Grojec; Edward J N Ishac; J Kapocsi; George Kunos
The effect of essential fatty acid deficiency on the adrenergic activation of glycogenolysis in rat hepatocytes.
Archives of biochemistry and biophysics 1990;283(1):34-9.
1990: Miklós Hollósi; Helga Süli-Vargha; Katalin F Medzihradszky; G D Fasman; George Kunos; László Gráf
Structural determinants of the binding of gliadin fragments to human peripheral blood lymphocytes.
Neuropeptides 1990;17(3):111-6.
1990: S Caneschi; P Cazzaniga; G Frigeni; George Kunos; M Pastori; E Rosa
[Correlations of clinical and diagnostic-instrumental variables in the prognostic function in 2 series of patients in traumatic cerebral coma].
Minerva anestesiologica 1990;56(10):1297-8.
1990: T Nakane; T Szentendrei; L Stern; M Virmani; J Seely; George Kunos
Effects of IL-1 and cortisol on beta-adrenergic receptors, cell proliferation, and differentiation in cultured human A549 lung tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):260-6.
1989: J A Mastrianni; Frances V Abbott; George Kunos
Activation of central mu-opioid receptors is involved in clonidine analgesia in rats.
Brain research 1989;479(2):283-9.
1989: George Kunos
Adrenergic receptor research: recent developments.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1989;33():151-67.
1989: J A Mastrianni; Miklós Palkovits; George Kunos
Activation of brainstem endorphinergic neurons causes cardiovascular depression and facilitates baroreflex bradycardia.
Neuroscience 1989;33(3):559-66.
1988: L Stern; George Kunos
Synergistic regulation of pulmonary beta-adrenergic receptors by glucocorticoids and interleukin-1.
The Journal of biological chemistry 1988;263(31):15876-9.
1988: R Mosqueda-Garcia; George Kunos
Peripheral opiate receptors are not involved in the naloxone-sensitive cardiovascular effects of clonidine in rats.
Brain research 1988;442(1):119-23.
1988: George Kunos; R Mosqueda-Garcia
Endogenous opioid involvement in the cardiovascular effects of clonidine in rats: role of the parasympathetic nervous system.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10 Suppl 1():369-74.
1987: R Mosqueda-Garcia; George Kunos
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8637-41.
1987: George Kunos; R Mosqueda-Garcia; J A Mastrianni; Frances V Abbott
Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine.
Canadian journal of physiology and pharmacology 1987;65(8):1624-32.
1987: Edward J N Ishac; George Kunos
Time dependent conversion from alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat hepatocytes: role of membrane phospholipase A2 and protein kinase C.
Clinical and experimental pharmacology & physiology 1987;14(5):429-35.
1987: George Kunos; Edward J N Ishac
Mechanism of inverse regulation of alpha 1- and beta-adrenergic receptors.
Biochemical pharmacology 1987;36(8):1185-91.
1987: Edward J N Ishac; R Eskay; Fusao Hirata; Julius Axelrod; George Kunos
Adrenergic regulation of beta-endorphin secretion from anterior pituitary in conscious rats: effects of thyroid state.
Endocrinology 1987;120(3):1073-8.
1986: R Mosqueda-Garcia; R Eskay; N Zamir; Miklós Palkovits; George Kunos
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
Endocrinology 1986;118(5):1814-22.
1986: Fusao Hirata; Y Notsu; R Yamada; Y Ishihara; Y Wano; I Kunos; George Kunos
Isolation and characterization of lipocortin (lipomodulin).
Agents and actions 1986;17(3-4):263-6.
1986: Edward J N Ishac; George Kunos
An arachidonate metabolite is involved in the conversion from alpha 1- to beta-adrenergic glycogenolysis in isolated rat liver cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(1):53-7.
1985: George Kunos; I Kunos; Fusao Hirata; Edward J N Ishac
Adrenergic receptors: possible mechanism of inverse regulation of alpha- and beta-receptors.
The Journal of allergy and clinical immunology 1985;76(2 Pt 2):346-51.
1985: L Tchakarov; F V Abbott; M D Ramirez-Gonzalez; George Kunos
Naloxone reverses the antinociceptive action of clonidine in spontaneously hypertensive rats.
Brain research 1985;328(1):33-40.
1985: C Farsang; J Kapocsi; K Varga; L Vajda; A Balás-Eltes; George Kunos
beta-Endorphin and essential hypertension: importance of the clonidine-naloxone interaction.
Acta physiologica Hungarica 1985;65(2):217-26.
1985: George Kunos; Edward J N Ishac; A Nador; P Lapchak
Molecular mechanism of inverse regulation of hepatic alpha-1 and beta-2-adrenergic receptors.
Progress in neuro-psychopharmacology & biological psychiatry 1985;9(5-6):497-502.
1985: George Kunos; Edward J N Ishac
Inverse reciprocal regulation of alpha 1- and beta 2-adrenoceptors in the rat liver: possible mechanism.
Journal of cardiovascular pharmacology 1985;7 Suppl 6():S87-92.
1984: George Kunos; F Newman; C Farsang; W Ungar
Thyrotropin releasing hormone and naloxone attenuate the antihypertensive action of central alpha 2-adrenoceptor stimulation through different mechanisms.
Endocrinology 1984;115(6):2481-3.
1984: George Kunos; Fusao Hirata; Edward J N Ishac; L Tchakarov
Time-dependent conversion of alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat liver cells: role of membrane phospholipase A2.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(19):6178-82.
1984: C Farsang; K Varga; L Vajda; J Kapocsi; A Balás-Eltes; George Kunos
Beta-endorphin contributes to the antihypertensive effect of clonidine in a subset of patients with essential hypertension.
Neuropeptides 1984;4(4):293-302.
1984: C Farsang; J Kapocsi; L Vajda; K Varga; Z Malisak; M Fekete; George Kunos
Reversal by naloxone of the antihypertensive action of clonidine: involvement of the sympathetic nervous system.
Circulation 1984;69(3):461-7.
1983: C Farsang; L Vajda; Z Malisák; M Fekete; J Kapocsi; K Varga; George Kunos
[The role of beta endorphin in the antihypertensive action of clonidine, associated with sympathetic tonus decrease, in essential hypertension].
Orvosi hetilap 1983;124(43):2603-9.
1983: M D Ramirez-Gonzalez; L Tchakarov; R Mosqueda Garcia; George Kunos
beta-endorphin acting on the brainstem is involved in the antihypertensive action of clonidine and alpha-methyldopa in rats.
Circulation research 1983;53(2):150-7.
1983: K Varga; J Kapocsi; I Juhász; George Kunos; C Farsang
[Hemodynamic effects of naloxone during clonidine treatment of patients with essential hypertension].
Orvosi hetilap 1983;124(17):991-5.
1983: C Farsang; L Vajda; J Kapocsi; Z Malisák; S Alföldi; K Varga; I Juhász; George Kunos
Diurnal rhythm of beta endorphin in normotensive and hypertensive patients: the effect of clonidine.
The Journal of clinical endocrinology and metabolism 1983;56(4):865-7.
1983: George Kunos; W H Kan; R Greguski; J C Venter
Selective affinity labeling and molecular characterization of hepatic alpha 1-adrenergic receptors with [3H]phenoxybenzamine.
The Journal of biological chemistry 1983;258(1):326-32.
1983: J Kapocsi; L Vajda; Z Malisák; I Juhász; George Kunos; C Farsang
[The effect of naloxone on plasma renin activity in patients with essential hypertension treated with clonidine].
Orvosi hetilap 1983;124(2):71-4.
1983: C Farsang; M D Ramirez-Gonzalez; L Tchakarov; George Kunos
Possible role of an endogenous opioid in the antihypertensive action of propranolol in spontaneously hypertensive rats.
Acta physiologica Hungarica 1983;62(2):167-75.
1982: C Farsang; J Kapocsi; I Juhasz; George Kunos
Possible involvement of an endogenous opioid in the antihypertensive effect of clonidine in patients with essential hypertension.
Circulation 1982;66(6):1268-72.
1982: M D Ramirez-Gonzalez; C Farsang; L Tchakarov; George Kunos
Opiate antagonists reverse the centrally mediated antihypertensive action of propranolol in spontaneously hypertensive rats.
European journal of pharmacology 1982;81(1):167-70.
1982: H Y Chang; R M Klein; George Kunos
Selective desensitization of cardiac beta adrenoceptors by prolonged in vivo infusion of catecholamines in rats.
The Journal of pharmacology and experimental therapeutics 1982;221(3):784-9.
1982: H G Preiksaitis; W H Kan; George Kunos
Decreased alpha 1-adrenoceptor responsiveness and density in liver cells of thyroidectomized rats.
The Journal of biological chemistry 1982;257(8):4321-7.
1981: H Y Chang; George Kunos
Short term effects of triiodothyronine on rat heart adrenoceptors.
Biochemical and biophysical research communications 1981;100(1):313-20.
1981: George Kunos; C Farsang; M D Ramirez-Gonzales
beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation.
Science (New York, N.Y.) 1981;211(4477):82-4.
1980: C Farsang; M D Ramirez-Gonzalez; L Mucci; George Kunos
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1980;214(1):203-8.
1980: George Kunos; L Mucci; S O'Regan
The influence of hormonal and neuronal factors on rat heart adrenoceptors.
British journal of pharmacology 1980;71(2):371-86.
1979: W H Kan; C Farsang; H G Preiksaitis; George Kunos
Affinity labelling of alpha-adrenoceptors in intact liver cells by [3H]phenoxybenzamine.
Biochemical and biophysical research communications 1979;91(1):303-11.
1979: C Farsang; George Kunos
Naloxone reverses the antihypertensive effect of clonidine.
British journal of pharmacology 1979;67(2):161-4.
1979: George Kunos; B Hoffman; Y N Kwok; W H Kan; L Mucci
Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle.
Nature 1979;278(5701):254-6.
1979: H G Preiksaitis; George Kunos
Adrenoceptor-mediated activation of liver glycogen phosphorylase: effects of thyroid state.
Life sciences 1979;24(1):35-41.
1978: George Kunos; B Robertson; W H Kan; H Preiksaitis; L Mucci
Adrenergic reactivity of the myocardium in hypertension.
Life sciences 1978;22(10):847-54.
1978: George Kunos
Adrenoceptors.
Annual review of pharmacology and toxicology 1978;18():291-311.
1977: M Nickerson; George Kunos
Discussion of evidence regarding induced changes in adrenoceptors.
Federation proceedings 1977;36(12):2580-3.
1977: George Kunos; M Nickerson
Effects of sympathetic innervation and temperature on the properties of rat heart adrenoceptors.
British journal of pharmacology 1977;59(4):603-14.
1977: George Kunos
Thyroid hormone-dependent interconversion of myocardial alpha- and beta-adrenoceptors in the rat.
British journal of pharmacology 1977;59(1):177-89.
1976: George Kunos; L Mucci; V Jaeger
Interconversion of myocardial adrenoceptors: its relationship to adenylate cyclase activation.
Life sciences 1976;19(10):1597-602.
1976: M Szentiványi; George Kunos; A Juhász-NAGY
Unmasking of sympathetic vasoconstruction of the coronary vessels after acute administration of reserpine to dogs.
Canadian journal of physiology and pharmacology 1976;54(2):166-9.
1976: George Kunos; M Nickerson
Temperature-induced interconversion of alpha-and beta-adrenoceptors in the frog heart.
The Journal of physiology 1976;256(1):23-40.
1976: George Kunos; M Nickerson
Letter: Temperature, phenoxybenzamine and adrenoceptor transformation.
Nature 1976;259(5540):251-2.
1975: George Kunos; G Magni; A Scimè
[Study of a case of prolonged apnea due to pancuronium bromide and resistant to anticholinesterase treatment].
Minerva anestesiologica 1975;41(4):178-80.
1974: George Kunos; I Vermes-Kunos; M Nickerson
Effects of thyroid state on adrenoceptor properties.
Nature 1974;250(5469):779-81.
1974: B Allaria; B Decio; George Kunos; M Libutti
[Effect of the ketamine-induced anesthesia on the cardiovascular apparatus].
Minerva anestesiologica 1974;40(6):269-73.
1974: B G Benfey; George Kunos; M Nickerson
Dissociation of cardiac inotropic and adenylate cyclast activating adrenoceptors.
British journal of pharmacology 1974;51(2):253-7.
1974: B G Benfey; J Cohen; George Kunos; I Vermes-Kunos
Dissociation of 5-hydroxytryptamine effects on myocardial contractility and cyclic AMP accumulation.
British journal of pharmacology 1974;50(4):581-5.
1973: R Cseuz; T L Wenger; George Kunos; M Szentiványi
Changes of adrenergic reaction pattern in experimental diabetes mellitus.
Endocrinology 1973;93(3):752-5.
1973: George Kunos; M S Yong; M Nickerson
Transformation of adrenergic receptors in the myocardium.
Nature: New biology 1973;241(108):119-20.
1970: A G Kovách; J Hamar; O Dora; I Marton; George Kunos; E Kun
[Effect of coumarin from Melilotus officinalis on the blood circulation of the dog].
Arzneimittel-Forschung 1970;20(11):Suppl 11a:1630+.
1970: M Szentiványi; S Juhász-Nagy; George Kunos
[Neurologic control of coronary disease and its pathophysiologic implications].
Orvosi hetilap 1970;111(38):2229-32.
1970: M Szentiványi; George Kunos; A Juhász-Nagy
Modulator theory of adrenergic receptor mechanism: vessels of the dog hindlimb.
The American journal of physiology 1970;218(3):869-75.
1968: A G Kovách; L Simon; P Sándor; George Kunos; I Marton; E Kun
[Studies on the effect of 2-ethyl-3,3-diphenyl propen-(2)-yl-amine in experimental hemorrhagic and ischemic shock].
Arzneimittel-Forschung 1968;18(9):1203-5.
1968: E Kun; George Kunos; I Marton; A G Kovách
[Comparative studies on the effect of 2-ethyl-3,3-diphenyl-propen (2)-yl-amine and adrenaline on the blood pressure, liver- and kidney circulation].
Die Medizinische Welt 1968;20():1298-301.
1968: George Kunos; M Szentivanyi
Evidence favouring the existence of a single adrenergic receptor.
Nature 1968;217(5133):1077-8.
1967: A Citro; G Calligari; George Kunos
[Neuroleptoanalgesia. 3 years of experience].
Minerva anestesiologica 1967;33(10):726-8.
1965: A G KOVACH; George Kunos; I MARTON; E KUN
[THE EFFECT OF 2-ETHYL-3,3-DIPHENYL-2-PROPENYLAMINE ON THE CIRCULATION AND BLOOD SUPPLY OF THE MYOCARDIUM AND THE KIDNEY CORTEX AFTER HEMORRHAGIC HYPOTENSION].
Arzneimittel-Forschung 1965;15():175-8.
1965: G Calligari; A Citro; George Kunos
[Behavior of gastrointestinal motility in patients exposed to neuroleptoanalgesia of type II and to traditional anesthesia. (Clinical findings)].
Acta anaesthesiologica 1965;16():Suppl 3:225-35.