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Brian Murphy

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Jim Boonyaratanakornkit; Emmalene Bartlett; Henrick Schomacker; Sonja R Surman; Shizuo Akira; Yong-Soo Bae; Peter Collins; Brian Murphy; Alexander Schmidt
The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.
Olga Maximova; Lawrence J Faucette; Jerrold M Ward; Brian Murphy; Alexander G Pletnev
Cellular inflammatory response to flaviviruses in the central nervous system of a primate host.
Cindy L Luongo; Lijuan Yang; Christine C Winter; Kirsten M Spann; Brian Murphy; Peter L Collins; Ursula J Buchholz
Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates.

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2011: Jim Boonyaratanakornkit; Emmalene Bartlett; Henrick Schomacker; Sonja R Surman; Shizuo Akira; Yong-Soo Bae; Peter Collins; Brian Murphy; Alexander Schmidt
The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.
Journal of virology 2011;85(4):1495-506.
2009: Olga Maximova; Lawrence J Faucette; Jerrold M Ward; Brian Murphy; Alexander G Pletnev
Cellular inflammatory response to flaviviruses in the central nervous system of a primate host.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009;57(10):973-89.
2009: Cindy L Luongo; Lijuan Yang; Christine C Winter; Kirsten M Spann; Brian Murphy; Peter L Collins; Ursula J Buchholz
Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates.
Vaccine 2009;27(41):5667-76.
2009: Ruth A Karron; KAWSAR TALAAT; Catherine Luke; Karen Callahan; Bhagvanji Thumar; Susan Dilorenzo; Josephine McAuliffe; Elizabeth Schappell; Amorsolo Suguitan; Kimberly Mills; Grace Chen; Elaine W Lamirande; Kathleen L Coelingh; Hong Jin; Brian Murphy; George W Kemble; Kanta Subbarao
Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults.
Vaccine 2009;27(36):4953-60.
2009: KAWSAR TALAAT; Ruth A Karron; Karen Callahan; Catherine J Luke; Susan C DiLorenzo; Grace L Chen; Elaine W Lamirande; Hong Jin; Kathleen L Coelingh; Brian Murphy; George W Kemble; Kanta Subbarao
A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.
Vaccine 2009;27(28):3744-53.
2009: Joshua M DiNapoli; Jerrold M Ward; Lily Cheng; Lijuan Yang; Subbiah Elankumaran; Brian Murphy; Siba K. Samal; Peter L Collins; Alexander Bukreyev
Delivery to the lower respiratory tract is required for effective immunization with Newcastle disease virus-vectored vaccines intended for humans.
Vaccine 2009;27(10):1530-9.
2009: Ruth A Karron; Karen Callahan; Catherine Luke; Bhagvanji Thumar; Josephine McAuliffe; Elizabeth Schappell; Tomy Joseph; Kathleen L Coelingh; Hong Jin; George W Kemble; Brian Murphy; Kanta Subbarao
A live attenuated H9N2 influenza vaccine is well tolerated and immunogenic in healthy adults.
The Journal of infectious diseases 2009;199(5):711-6.
2009: Jim B Boonyaratanakornkit; Emmalene J Bartlett; Emerito Amaro-Carambot; Peter L Collins; Brian Murphy; Alexander C Schmidt
The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infection.
Journal of virology 2009;83(4):1892-910.
2009: Alexander Bukreyev; Andrea Marzi; Friederike Feldmann; Liqun Zhang; Lijuan Yang; Jerrold M Ward; David W Dorward; Raymond J Pickles; Brian Murphy; Heinz Feldmann; Peter L Collins
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge.
Virology 2009;383(2):348-61.
2008: Alexander Bukreyev; Lijuan Yang; Jens Fricke; Lily Cheng; Jerrold M Ward; Brian Murphy; Peter L Collins
The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes.
Journal of virology 2008;82(24):12191-204.
2008: Julie H McArthur; Anna P Durbin; Jennifer A Marron; Kimberli A Wanionek; Bhagvanji Thumar; Dennis J Pierro; Alexander C Schmidt; Joseph E Blaney; Brian Murphy; Stephen S Whitehead
Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicity.
The American journal of tropical medicine and hygiene 2008;79(5):678-84.
2008: Peter L Collins; Alexander Bukreyev; Brian Murphy
What are the risks--hypothetical and observed--of recombination involving live vaccines and vaccine vectors based on nonsegmented negative-strain RNA viruses?
Journal of virology 2008;82(19):9805-6.
2008: Emmalene J Bartlett; Ann-Marie Cruz; Janice Esker; Adam Castaño; Henrick Schomacker; Sonja R Surman; Margaret Hennessey; Jim Boonyaratanakornkit; Raymond J Pickles; Peter L Collins; Brian Murphy; Alexander C Schmidt
Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates.
Journal of virology 2008;82(18):8965-77.
2008: Joseph E Blaney; Jim Speicher; Christopher T Hanson; Neeraj S Sathe; Stephen S Whitehead; Brian Murphy; Alexander G Pletnev
Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys.
Vaccine 2008;26(33):4150-9.
2008: Lijuan Yang; Anthony Sanchez; Jerrold M Ward; Brian Murphy; Peter L Collins; Alexander Bukreyev
A paramyxovirus-vectored intranasal vaccine against Ebola virus is immunogenic in vector-immune animals.
Virology 2008;377(2):255-64.
2008: Emmalene J Bartlett; Margaret Hennessey; Mario Skiadopoulos; Alexander C Schmidt; Peter L Collins; Brian Murphy; Raymond J Pickles
Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium.
Journal of virology 2008;82(16):8059-70.
2008: Olga Maximova; Jerrold M Ward; David M Asher; Marisa St Claire; Brad W Finneyfrock; James M Speicher; Brian Murphy; Alexander G Pletnev
Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in nonhuman primates.
Journal of virology 2008;82(11):5255-68.
2008: Peter F Wright; Sharon Ankrah; Susan E Henderson; Anna P Durbin; Jim Speicher; Stephen S Whitehead; Brian Murphy; Alexander G Pletnev
Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers.
Vaccine 2008;26(7):882-90.
2008: Joseph E Blaney; Neeraj S Sathe; Laura B Goddard; Christopher T Hanson; Tammy A Romero; Kathryn A Hanley; Brian Murphy; Stephen S Whitehead
Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3' untranslated region (3'-UTR) or by exchange of the DENV-3 3'-UTR with that of DENV-4.
Vaccine 2008;26(6):817-28.
2008: Joshua M DiNapoli; Brian Murphy; Peter L Collins; Alexander Bukreyev
Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection.
Virology journal 2008;5():105.
2008: Richard G Bennett; Christina M Cress; Jerrold M Ward; Cai-Yen Firestone; Brian Murphy; Stephen S Whitehead
La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys.
Virology journal 2008;5():25.
2007: Hong Jin; Timothy Scott Manetz; J Leininger; C Luke; K Subbarao; Brian Murphy; George W Kemble; Kathleen L Coelingh
Toxicological evaluation of live attenuated, cold-adapted H5N1 vaccines in ferrets.
Vaccine 2007;25(52):8664-72.
2007: Joshua M DiNapoli; Lijuan Yang; Amorsolo Suguitan; Subbiah Elankumaran; David W Dorward; Brian Murphy; Siba K. Samal; Peter L Collins; Alexander Bukreyev
Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus.
Journal of virology 2007;81(21):11560-8.
2007: Peter F Wright; Ruth A Karron; Robert B Belshe; Jian R Shi; Valerie B Randolph; Peter L Collins; Alice F O'Shea; William C Gruber; Brian Murphy
The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines.
Vaccine 2007;25(42):7372-8.
2007: Sheila M Nolan; Mario Skiadopoulos; Konrad Bradley; Olivia S Kim; Stacia Bier; Emerito Amaro-Carambot; Sonja R Surman; Stephanie Davis; Marisa St Claire; Randy Elkins; Peter L Collins; Brian Murphy; Anne Schaap-Nutt
Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.
Vaccine 2007;25(34):6409-22.
2007: Stephen S Whitehead; Joseph E Blaney; Anna P Durbin; Brian Murphy
Prospects for a dengue virus vaccine.
Nature reviews. Microbiology 2007;5(7):518-28.
2007: Joshua M DiNapoli; Alexander Kotelkin; Lijuan Yang; Subbiah Elankumaran; Brian Murphy; Siba K. Samal; Peter L Collins; Alexander Bukreyev
Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9788-93.
2007: Alexander Bukreyev; Pierre E Rollin; Mallory K Tate; Lijuan Yang; Sherif R Zaki; Wun-Ju Shieh; Brian Murphy; Peter L Collins; Anthony Sanchez
Successful topical respiratory tract immunization of primates against Ebola virus.
Journal of virology 2007;81(12):6379-88.
2007: stephane biacchesi; Brian Murphy; Peter L Collins; Ursula J Buchholz
Frequent frameshift and point mutations in the SH gene of human metapneumovirus passaged in vitro.
Journal of virology 2007;81(11):6057-67.
2007: Sonja R Surman; Peter L Collins; Brian Murphy; Mario Skiadopoulos
An improved method for the recovery of recombinant paramyxovirus vaccine candidates suitable for use in human clinical trials.
Journal of virological methods 2007;141(1):30-3.
2007: Emmalene J Bartlett; Adam Castaño; Sonja R Surman; Peter L Collins; Mario Skiadopoulos; Brian Murphy
Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes.
Virology journal 2007;4():67.
2007: Richard G Bennett; David R Ton; Christopher T Hanson; Brian Murphy; Stephen S Whitehead
Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes.
Virology journal 2007;4():41.
2007: Joseph E Blaney; Neeraj S Sathe; Christopher T Hanson; Cai-Yen Firestone; Brian Murphy; Stephen S Whitehead
Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1.
Virology journal 2007;4():23.
2006: Anna P Durbin; Julie H McArthur; Jennifer A Marron; Joseph E Blaney; Bhagvanji Thumar; Kimberli Wanionek; Brian Murphy; Stephen S Whitehead
rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults.
Human vaccines 2006;2(6):255-60.
2006: Alexander Bukreyev; Mario Skiadopoulos; Brian Murphy; Peter L Collins
Nonsegmented negative-strand viruses as vaccine vectors.
Journal of virology 2006;80(21):10293-306.
2006: Ursula J Buchholz; Kunio Nagashima; Brian Murphy; Peter L Collins
Live vaccines for human metapneumovirus designed by reverse genetics.
Expert review of vaccines 2006;5(5):695-706.
2006: Alexander G Pletnev; David E Swayne; Jim Speicher; Alexander A Rumyantsev; Brian Murphy
Chimeric West Nile/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity.
Vaccine 2006;24(40-41):6392-404.
2006: Amorsolo Suguitan; Josephine McAuliffe; Kimberly L Mills; Hong Jin; Gregory M Duke; Bin Lu; Catherine J Luke; Brian Murphy; David E Swayne; George W Kemble; Kanta Subbarao
Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.
PLoS medicine 2006;3(9):e360.
2006: William Van Cleve; Emerito Amaro-Carambot; Sonja R Surman; Joseph Bekisz; Peter L Collins; Kathy Zoon; Brian Murphy; Mario Skiadopoulos; Emmalene J Bartlett
Attenuating mutations in the P/C gene of human parainfluenza virus type 1 (HPIV1) vaccine candidates abrogate the inhibition of both induction and signaling of type I interferon (IFN) by wild-type HPIV1.
Virology 2006;352(1):61-73.
2006: Anna P Durbin; Julie H McArthur; Jennifer A Marron; Joseph E Blaney; Bhagvanji Thumar; Kim Wanionek; Brian Murphy; Stephen S Whitehead
The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.
Human vaccines 2006;2(4):167-73.
2006: stephane biacchesi; Quynh N Pham; Mario Skiadopoulos; Brian Murphy; Peter L Collins; Ursula J Buchholz
Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates.
Journal of virology 2006;80(12):5798-806.
2006: Emmalene J Bartlett; Emerito Amaro-Carambot; Sonja R Surman; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Introducing point and deletion mutations into the P/C gene of human parainfluenza virus type 1 (HPIV1) by reverse genetics generates attenuated and efficacious vaccine candidates.
Vaccine 2006;24(14):2674-84.
2006: Shabir A Madhi; Clare Cutland; Yuwei Zhu; Jill Hackell; Frances K Newman; Nigel Blackburn; Brian Murphy; Robert B Belshe; Ruth A Karron; Anne M Deatly; William C Gruber; David I Bernstein; Peter F Wright
Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers.
Vaccine 2006;24(13):2432-9.
2006: Alexander Bukreyev; Lijuan Yang; Sherif R Zaki; Wun-Ju Shieh; Pierre E Rollin; Brian Murphy; Peter L Collins; Anthony Sanchez
A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge.
Journal of virology 2006;80(5):2267-79.
2006: Mario Skiadopoulos; stephane biacchesi; Ursula J Buchholz; Emerito Amaro-Carambot; Sonja R Surman; Peter L Collins; Brian Murphy
Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity.
Virology 2006;345(2):492-501.
2006: Peter F Wright; Ruth A Karron; Shabir A Madhi; John J Treanor; James C King; Alice O'Shea; Mine R Ikizler; Yuwei Zhu; Peter L Collins; Clare Cutland; Valerie B Randolph; Anne M Deatly; Jill Hackell; William C Gruber; Brian Murphy
The interferon antagonist NS2 protein of respiratory syncytial virus is an important virulence determinant for humans.
The Journal of infectious diseases 2006;193(4):573-81.
2006: Alexander A Rumyantsev; Brian Murphy; Alexander G Pletnev
A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice.
Journal of virology 2006;80(3):1427-39.
2006: Alexander A Rumyantsev; Robert M Chanock; Brian Murphy; Alexander G Pletnev
Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys.
Vaccine 2006;24(2):133-43.
2006: Joseph E Blaney; Anna P Durbin; Brian Murphy; Stephen S Whitehead
Development of a live attenuated dengue virus vaccine using reverse genetics.
Viral immunology 2006;19(1):10-32.
2006: Kanta Subbarao; Brian Murphy; Anthony Fauci
Development of effective vaccines against pandemic influenza.
Immunity 2006;24(1):5-9.
2005: Quynh N Pham; stephane biacchesi; Mario Skiadopoulos; Brian Murphy; Peter L Collins; Ursula J Buchholz
Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo.
Journal of virology 2005;79(24):15114-22.
2005: Alexander Bukreyev; Zhuhui Huang; Lijuan Yang; Subbiah Elankumaran; Marisa St Claire; Brian Murphy; Siba K. Samal; Peter L Collins
Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates.
Journal of virology 2005;79(21):13275-84.
2005: stephane biacchesi; Quynh N Pham; Mario Skiadopoulos; Brian Murphy; Peter L Collins; Ursula J Buchholz
Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates.
Journal of virology 2005;79(19):12608-13.
2005: Sheila M Nolan; Sonja R Surman; Emerito Amaro-Carambot; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses.
Vaccine 2005;23(39):4765-74.
2005: Emmalene J Bartlett; Emerito Amaro-Carambot; Sonja R Surman; Jason T Newman; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Human parainfluenza virus type I (HPIV1) vaccine candidates designed by reverse genetics are attenuated and efficacious in African green monkeys.
Vaccine 2005;23(38):4631-46.
2005: Albert Z Kapikian; Lone Simonsen; Timo Vesikari; Yasutaka Hoshino; David M Morens; Robert M Chanock; John R La Montagne; Brian Murphy
A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusception.
The Journal of infectious diseases 2005;192 Suppl 1():S22-9.
2005: stephane biacchesi; Mario Skiadopoulos; Lijuan Yang; Brian Murphy; Peter L Collins; Ursula J Buchholz
Rapid human metapneumovirus microneutralization assay based on green fluorescent protein expression.
Journal of virological methods 2005;128(1-2):192-7.
2005: Konrad Stadler; Anjeanette Roberts; Stephan Becker; Leatrice Vogel; Markus Eickmann; Larissa Kolesnikova; Hans-Dieter Klenk; Brian Murphy; Rino Rappuoli; Sergio Abrignani; Kanta Subbarao
SARS vaccine protective in mice.
Emerging infectious diseases 2005;11(8):1312-4.
2005: Ursula J Buchholz; stephane biacchesi; Quynh N Pham; Kim C Tran; Lijuan Yang; Cindy L Luongo; Mario Skiadopoulos; Brian Murphy; Peter L Collins
Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity.
Journal of virology 2005;79(11):6588-97.
2005: Joseph E Blaney; Jennifer M Matro; Brian Murphy; Stephen S Whitehead
Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys.
Journal of virology 2005;79(9):5516-28.
2005: Ruth A Karron; Peter F Wright; Robert B Belshe; Bhagvanji Thumar; Roberta Casey; Frances K Newman; Fernando P Polack; Valerie B Randolph; Anne M Deatly; Jill Hackell; William C Gruber; Brian Murphy; Peter L Collins
Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants.
The Journal of infectious diseases 2005;191(7):1093-104.
2005: Anna P Durbin; Stephen S Whitehead; Julie H McArthur; John R Perreault; Joseph E Blaney; Bhagvanji Thumar; Brian Murphy; Ruth A Karron
rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteers.
The Journal of infectious diseases 2005;191(5):710-8.
2005: Peter L Collins; Brian Murphy
New generation live vaccines against human respiratory syncytial virus designed by reverse genetics.
Proceedings of the American Thoracic Society 2005;2(2):166-73.
2005: Kathryn A Hanley; Laura B Goddard; Lara E Gilmore; Thomas W Scott; Jim Speicher; Brian Murphy; Alexander G Pletnev
Infectivity of West Nile/dengue chimeric viruses for West Nile and dengue mosquito vectors.
Vector borne and zoonotic diseases (Larchmont, N.Y.) 2005;5(1):1-10.
2005: Anjeanette Roberts; Leatrice Vogel; Jeannette Guarner; Norman Hayes; Brian Murphy; Sherif Zaki; Kanta Subbarao
Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters.
Journal of virology 2005;79(1):503-11.
2004: Robert B Belshe; Frances K Newman; Edwin L Anderson; Peter F Wright; Ruth A Karron; Sharon J Tollefson; Frederick W Henderson; H Cody Meissner; Shabir A Madhi; Don Roberton; Helen Marshall; Richard Loh; Peter Sly; Brian Murphy; Joanne M Tatem; Valerie B Randolph; Jill Hackell; William C Gruber; Theodore F Tsai
Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children.
The Journal of infectious diseases 2004;190(12):2096-103.
2004: Josephine McAuliffe; Leatrice Vogel; Anjeanette Roberts; Gary A Fahle; Steven Fischer; Wun-Ju Shieh; Emily Butler; Sherif Zaki; Marisa St Claire; Brian Murphy; Kanta Subbarao
Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys.
Virology 2004;330(1):8-15.
2004: Joseph E Blaney; Christopher T Hanson; Cai-Yen Firestone; Kathryn A Hanley; Brian Murphy; Stephen S Whitehead
Genetically modified, live attenuated dengue virus type 3 vaccine candidates.
The American journal of tropical medicine and hygiene 2004;71(6):811-21.
2004: stephane biacchesi; Mario Skiadopoulos; Lijuan Yang; Elaine W Lamirande; Kim C Tran; Brian Murphy; Peter L Collins; Ursula J Buchholz
Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate.
Journal of virology 2004;78(23):12877-87.
2004: Joseph E Blaney; Christopher T Hanson; Kathryn A Hanley; Brian Murphy; Stephen S Whitehead
Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2.
BMC infectious diseases 2004;4():39.
2004: Kathryn A Hanley; Luella R Manlucu; Gracielle G Manipon; Christopher T Hanson; Stephen S Whitehead; Brian Murphy; Joseph E Blaney
Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity.
Vaccine 2004;22(25-26):3440-8.
2004: Brian Murphy; Joseph E Blaney; Stephen S Whitehead
Arguments for live flavivirus vaccines.
Lancet 2004;364(9433):499-500.
2004: Elisabetta Traggiai; Stephan Becker; Kanta Subbarao; Larissa Kolesnikova; Yasushi Uematsu; Maria Rita Gismondo; Brian Murphy; Rino Rappuoli; Antonio Lanzavecchia
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus.
Nature medicine 2004;10(8):871-5.
2004: Mario Skiadopoulos; stephane biacchesi; Ursula J Buchholz; Jeffrey M Riggs; Sonja R Surman; Emerito Amaro-Carambot; Josephine McAuliffe; William R Elkins; Marisa St Claire; Peter L Collins; Brian Murphy
The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness.
Journal of virology 2004;78(13):6927-37.
2004: Ursula J Buchholz; Alexander Bukreyev; Lijuan Yang; Elaine W Lamirande; Brian Murphy; Kanta Subbarao; Peter L Collins
Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9804-9.
2004: Alexander Bukreyev; Elaine W Lamirande; Ursula J Buchholz; Leatrice N Vogel; William R Elkins; Marisa St Claire; Brian Murphy; Kanta Subbarao; Peter L Collins
Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.
Lancet 2004;363(9427):2122-7.
2004: Michael G Ison; Sebastian L Johnston; Peter Openshaw; Brian Murphy; Frederick G Hayden
Current research on respiratory viral infections: Fifth International Symposium.
Antiviral research 2004;62(3):75-110.
2004: Himani Bisht; Anjeanette Roberts; Leatrice Vogel; Alexander Bukreyev; Peter L Collins; Brian Murphy; Kanta Subbarao; Bernard Moss
Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6641-6.
2004: stephane biacchesi; Mario Skiadopoulos; Kim C Tran; Brian Murphy; Peter L Collins; Ursula J Buchholz
Recovery of human metapneumovirus from cDNA: optimization of growth in vitro and expression of additional genes.
Virology 2004;321(2):247-59.
2004: Zhi-Yong Yang; Wing-Pui Kong; Yue Huang; Anjeanette Roberts; Brian Murphy; Kanta Subbarao; Gary Nabel
A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice.
Nature 2004;428(6982):561-4.
2004: Kanta Subbarao; Josephine McAuliffe; Leatrice Vogel; Gary A Fahle; Steven Fischer; Kathleen Tatti; Michelle Packard; Wun-Ju Shieh; Sherif Zaki; Brian Murphy
Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice.
Journal of virology 2004;78(7):3572-7.
2004: Josephine McAuliffe; Sonja R Surman; Jason T Newman; Jeffrey M Riggs; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro.
Journal of virology 2004;78(4):2029-36.
2004: Jason T Newman; Jeffrey M Riggs; Sonja R Surman; Josephine McAuliffe; Teresa A Mulaikal; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Generation of recombinant human parainfluenza virus type 1 vaccine candidates by importation of temperature-sensitive and attenuating mutations from heterologous paramyxoviruses.
Journal of virology 2004;78(4):2017-28.
2004: Robert B Belshe; Frances K Newman; Theodore F Tsai; Ruth A Karron; Keith S Reisinger; Don Roberton; Helen Marshall; Richard Schwartz; James C King; Frederick W Henderson; William Rodriguez; Joseph M Severs; Peter F Wright; Harry Keyserling; Geoffrey A Weinberg; Kenneth Bromberg; Richard Loh; Peter Sly; Peter McIntyre; John B Ziegler; Jill Hackell; Anne M Deatly; Alice Georgiu; Maribel Paschalis; Shin-Lu Wu; Joanne M Tatem; Brian Murphy; Edwin Anderson
Phase 2 evaluation of parainfluenza type 3 cold passage mutant 45 live attenuated vaccine in healthy children 6-18 months old.
The Journal of infectious diseases 2004;189(3):462-70.
2003: stephane biacchesi; Mario Skiadopoulos; Guy Boivin; Christopher T Hanson; Brian Murphy; Peter L Collins; Ursula J Buchholz
Genetic diversity between human metapneumovirus subgroups.
Virology 2003;315(1):1-9.
2003: H Chen; Y Matsuoka; David Swayne; Q Chen; N J Cox; Brian Murphy; K Subbarao
Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate.
Vaccine 2003;21(27-30):4430-6.
2003: Joseph E Blaney; Gracielle G Manipon; Cai-Yen Firestone; Daniel H Johnson; Christopher T Hanson; Brian Murphy; Stephen S Whitehead
Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells.
Vaccine 2003;21(27-30):4317-27.
2003: Stephen S Whitehead; Kathryn A Hanley; Joseph E Blaney; Lara E Gilmore; William R Elkins; Brian Murphy
Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys.
Vaccine 2003;21(27-30):4307-16.
2003: Alexander G Pletnev; Marisa St Claire; Randy Elkins; Jim Speicher; Brian Murphy; Robert M Chanock
Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus.
Virology 2003;314(1):190-5.
2003: Kathryn A Hanley; Luella R Manlucu; Lara E Gilmore; Joseph E Blaney; Christopher T Hanson; Brian Murphy; Stephen S Whitehead
A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.
Virology 2003;312(1):222-32.
2003: Ruth A Karron; Robert B Belshe; Peter F Wright; Bhagvanji Thumar; Barbars Burns; Frances K Newman; Joan C Cannon; Juliette Thompson; Theodore Tsai; Maribel Paschalis; Shin-Lu Wu; Yvonne Mitcho; Jill Hackell; Brian Murphy; Joanne M Tatem
A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in young infants.
The Pediatric infectious disease journal 2003;22(5):394-405.
2003: Joseph E Blaney; Gracielle G Manipon; Brian Murphy; Stephen S Whitehead
Temperature sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restrict replication in the brains of mice.
Archives of virology 2003;148(5):999-1006.
2003: Brian Murphy; David M Morens; Lone Simonsen; Robert M Chanock; John R La Montagne; Albert Z Kapikian
Reappraisal of the association of intussusception with the licensed live rotavirus vaccine challenges initial conclusions.
The Journal of infectious diseases 2003;187(8):1301-8.
2003: Hualan Chen; Yumiko Matsuoka; Q Chen; Nancy J Cox; Brian Murphy; Kanta Subbarao
Generation and characterization of an H9N2 cold-adapted reassortant as a vaccine candidate.
Avian diseases 2003;47(3 Suppl):1127-30.
2003: Stephen S Whitehead; Barry Falgout; Kathryn A Hanley; Joseph E Blaney Jr; Lewis Markoff; Brian Murphy
A live, attenuated dengue virus type 1 vaccine candidate with a 30-nucleotide deletion in the 3' untranslated region is highly attenuated and immunogenic in monkeys.
Journal of virology 2003;77(2):1653-7.
2003: Mario Skiadopoulos; Alexander C Schmidt; Jeffrey M Riggs; Sonja R Surman; William R Elkins; Marisa St Claire; Peter L Collins; Brian Murphy
Determinants of the host range restriction of replication of bovine parainfluenza virus type 3 in rhesus monkeys are polygenic.
Journal of virology 2003;77(2):1141-8.
2003: Mario Skiadopoulos; Leatrice Vogel; Jeffrey M Riggs; Sonja R Surman; Peter L Collins; Brian Murphy
The genome length of human parainfluenza virus type 2 follows the rule of six, and recombinant viruses recovered from non-polyhexameric-length antigenomic cDNAs contain a biased distribution of correcting mutations.
Journal of virology 2003;77(1):270-9.
2002: Alexander Bukreyev; Mario Skiadopoulos; Josephine McAuliffe; Brian Murphy; Peter L Collins; Alexander C Schmidt
More antibody with less antigen: can immunogenicity of attenuated live virus vaccines be improved?
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16987-91.
2002: Christine Krempl; Brian Murphy; Peter L Collins
Recombinant respiratory syncytial virus with the G and F genes shifted to the promoter-proximal positions.
Journal of virology 2002;76(23):11931-42.
2002: Karoll J Cortez; Brian Murphy; K N Almeida; J Beeler; R A Levandowski; Vee J Gill; R W Childs; A John Barrett; M Smolskis; JOHN BENNETT
Immune-globulin prophylaxis of respiratory syncytial virus infection in patients undergoing stem-cell transplantation.
The Journal of infectious diseases 2002;186(6):834-8.
2002: Joseph E Blaney; Daniel H Johnson; Gracielle G Manipon; Cai-Yen Firestone; Christopher T Hanson; Brian Murphy; Stephen S Whitehead
Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells.
Virology 2002;300(1):125-39.
2002: Brian Murphy; Peter L Collins
Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics.
The Journal of clinical investigation 2002;110(1):21-7.
2002: Mario Skiadopoulos; Sonja R Surman; Jeffrey M Riggs; William R Elkins; Marisa St Claire; Machiko Nishio; Dominique Garcin; Daniel Kolakofsky; Peter L Collins; Brian Murphy
Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees.
Virology 2002;297(1):153-60.
2002: Mario Skiadopoulos; Sonja R Surman; Jeffrey M Riggs; Claes Orvell; Peter L Collins; Brian Murphy
Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins.
Virology 2002;297(1):136-52.
2002: Peter L Collins; Brian Murphy
Respiratory syncytial virus: reverse genetics and vaccine strategies.
Virology 2002;296(2):204-11.
2002: Mario Skiadopoulos; Joanne M Tatem; Sonja R Surman; Yvonne Mitcho; Shin-Lu Wu; William R Elkins; Brian Murphy
The recombinant chimeric human parainfluenza virus type 1 vaccine candidate, rHPIV3-1cp45, is attenuated, immunogenic, and protective in African green monkeys.
Vaccine 2002;20(13-14):1846-52.
2002: Alexander C Schmidt; Daniel R Wenzke; Josephine McAuliffe; Marisa St Claire; William R Elkins; Brian Murphy; Peter L Collins
Mucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backbone.
Journal of virology 2002;76(3):1089-99.
2002: Brian Murphy; Kathleen L Coelingh
Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines.
Viral immunology 2002;15(2):295-323.
2002: Jason T Newman; Sonja R Surman; Jeffrey M Riggs; Chris T Hansen; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Sequence analysis of the Washington/1964 strain of human parainfluenza virus type 1 (HPIV1) and recovery and characterization of wild-type recombinant HPIV1 produced by reverse genetics.
Virus genes 2002;24(1):77-92.
2002: Kathryn A Hanley; Jay J Lee; Joseph E Blaney; Brian Murphy; Stephen S Whitehead
Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.
Journal of virology 2002;76(2):525-31.
2001: Alexander Bukreyev; Igor M Belyakov; Jay A Berzofsky; Brian Murphy; Peter L Collins
Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells.
Journal of virology 2001;75(24):12128-40.
2001: Hirotaka Nishi; Makoto Senoo; K H Nishi; Brian Murphy; Toshiki Rikiyama; Y Matsumura; S Habu; Alfred C Johnson
p53 Homologue p63 represses epidermal growth factor receptor expression.
The Journal of biological chemistry 2001;276(45):41717-24.
2001: J M Troyer; Kathryn A Hanley; Stephen S Whitehead; Daniel Strickman; Ruth A Karron; Anna P Durbin; Brian Murphy
A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes.
The American journal of tropical medicine and hygiene 2001;65(5):414-9.
2001: Anna P Durbin; Ruth A Karron; W Sun; D W Vaughn; M J Reynolds; John R Perreault; Bhagvanji Thumar; Ruhe Men; Ching-Juh Lai; William R Elkins; Robert M Chanock; Brian Murphy; Stephen S Whitehead
Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.
The American journal of tropical medicine and hygiene 2001;65(5):405-13.
2001: Mario Skiadopoulos; Sonja R Surman; Jeffrey M Riggs; Peter L Collins; Brian Murphy
A chimeric human-bovine parainfluenza virus type 3 expressing measles virus hemagglutinin is attenuated for replication but is still immunogenic in rhesus monkeys.
Journal of virology 2001;75(21):10498-504.
2001: James Crowe; Cai-Yen Firestone; Brian Murphy
Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3910-8.
2001: Joseph E Blaney; Daniel H Johnson; Cai-Yen Firestone; Christopher T Hanson; Brian Murphy; Stephen S Whitehead
Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice.
Journal of virology 2001;75(20):9731-40.
2001: T Tao; Mario Skiadopoulos; F Davoodi; Sonja R Surman; Peter L Collins; Brian Murphy
Construction of a live-attenuated bivalent vaccine virus against human parainfluenza virus (PIV) types 1 and 2 using a recombinant PIV3 backbone.
Vaccine 2001;19(27):3620-31.
2001: Alexander C Schmidt; Robert B Couch; GJ Galasso; Frederick G Hayden; J Mills; Brian Murphy; Robert M Chanock
Current research on respiratory viral infections: Third International Symposium.
Antiviral research 2001;50(3):157-96.
2001: Alexander C Schmidt; Josephine McAuliffe; Brian Murphy; Peter L Collins
Recombinant bovine/human parainfluenza virus type 3 (B/HPIV3) expressing the respiratory syncytial virus (RSV) G and F proteins can be used to achieve simultaneous mucosal immunization against RSV and HPIV3.
Journal of virology 2001;75(10):4594-603.
2001: Clayton D Harro; Yuk-Ying S Pang; Richard B S Roden; Allan Hildesheim; Z Wang; M J Reynolds; T C Mast; R Robinson; Brian Murphy; Ruth A Karron; J Dillner; John T Schiller; Douglas Lowy
Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine.
Journal of the National Cancer Institute 2001;93(4):284-92.
2000: Alexander Bukreyev; Brian Murphy; Peter L Collins
Respiratory syncytial virus can tolerate an intergenic sequence of at least 160 nucleotides with little effect on transcription or replication in vitro and in vivo.
Journal of virology 2000;74(23):11017-26.
2000: Peter F Wright; Ruth A Karron; Robert B Belshe; Juliette Thompson; James Crowe; Thomas G Boyce; L L Halburnt; George W Reed; Stephen S Whitehead; Edwin L Anderson; A E Wittek; Roberta Casey; Maryna C Eichelberger; Bhagvanji Thumar; Valerie B Randolph; Stephen A Udem; Robert M Chanock; Brian Murphy
Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy.
The Journal of infectious diseases 2000;182(5):1331-42.
2000: Joyce A Feller; Sherin Smallwood; Mario Skiadopoulos; Brian Murphy; Sue A Moyer
Comparison of identical temperature-sensitive mutations in the L polymerase proteins of sendai and parainfluenza3 viruses.
Virology 2000;276(1):190-201.
2000: Michael N Teng; Stephen S Whitehead; Alison Bermingham; Marisa St Claire; William R Elkins; Brian Murphy; Peter L Collins
Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees.
Journal of virology 2000;74(19):9317-21.
2000: Alexander C Schmidt; Josephine McAuliffe; A Huang; Sonja R Surman; JE Bailly; William R Elkins; Peter L Collins; Brian Murphy; Mario Skiadopoulos
Bovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates.
Journal of virology 2000;74(19):8922-9.
2000: Alexander Bukreyev; Stephen S Whitehead; C Prussin; Brian Murphy; Peter L Collins
Effect of coexpression of interleukin-2 by recombinant respiratory syncytial virus on virus replication, immunogenicity, and production of other cytokines.
Journal of virology 2000;74(15):7151-7.
2000: Anna P Durbin; Mario Skiadopoulos; Josephine McAuliffe; Jeffrey M Riggs; Sonja R Surman; Peter L Collins; Brian Murphy
Human parainfluenza virus type 3 (PIV3) expressing the hemagglutinin protein of measles virus provides a potential method for immunization against measles virus and PIV3 in early infancy.
Journal of virology 2000;74(15):6821-31.
2000: T Tao; Mario Skiadopoulos; F Davoodi; Jeffrey M Riggs; Peter L Collins; Brian Murphy
Replacement of the ectodomains of the hemagglutinin-neuraminidase and fusion glycoproteins of recombinant parainfluenza virus type 3 (PIV3) with their counterparts from PIV2 yields attenuated PIV2 vaccine candidates.
Journal of virology 2000;74(14):6448-58.
2000: Mario Skiadopoulos; Sonja R Surman; Anna P Durbin; Peter L Collins; Brian Murphy
Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes.
Virology 2000;272(1):225-34.
2000: Anna P Durbin; William R Elkins; Brian Murphy
African green monkeys provide a useful nonhuman primate model for the study of human parainfluenza virus types-1, -2, and -3 infection.
Vaccine 2000;18(22):2462-9.
2000: Flor M Munoz; GJ Galasso; J M Gwaltney; Frederick G Hayden; Brian Murphy; R Webster; P Wright; Robert B Couch
Current research on influenza and other respiratory viruses: II international symposium.
Antiviral research 2000;46(2):91-124.
2000: JE Bailly; Josephine McAuliffe; Anna P Durbin; William R Elkins; Peter L Collins; Brian Murphy
A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates.
Journal of virology 2000;74(7):3188-95.
2000: I M Gonzalez; Ruth A Karron; Maryna C Eichelberger; Edward E Walsh; V W Delagarza; Richard G Bennett; Robert M Chanock; Brian Murphy; Mary Lou Clements-Mann; Ann R Falsey
Evaluation of the live attenuated cpts 248/404 RSV vaccine in combination with a subunit RSV vaccine (PFP-2) in healthy young and older adults.
Vaccine 2000;18(17):1763-72.
2000: Ursula J Buchholz; Harald Granzow; K Schuldt; S S Whitehead; Brian Murphy; Peter L Collins
Chimeric bovine respiratory syncytial virus with glycoprotein gene substitutions from human respiratory syncytial virus (HRSV): effects on host range and evaluation as a live-attenuated HRSV vaccine.
Journal of virology 2000;74(3):1187-99.
2000: T Tao; F Davoodi; C J Cho; Mario Skiadopoulos; Anna P Durbin; Peter L Collins; Brian Murphy
A live attenuated recombinant chimeric parainfluenza virus (PIV) candidate vaccine containing the hemagglutinin-neuraminidase and fusion glycoproteins of PIV1 and the remaining proteins from PIV3 induces resistance to PIV1 even in animals immune to PIV3.
Vaccine 2000;18(14):1359-66.
2000: JE Bailly; Josephine McAuliffe; Mario Skiadopoulos; Peter L Collins; Brian Murphy
Sequence determination and molecular analysis of two strains of bovine parainfluenza virus type 3 that are attenuated for primates.
Virus genes 2000;20(2):173-82.
1999: Stephen S Whitehead; M G Hill; Cai-Yen Firestone; Marisa St Claire; William R Elkins; Brian Murphy; Peter L Collins
Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates.
Journal of virology 1999;73(12):9773-80.
1999: Mario Skiadopoulos; T Tao; Sonja R Surman; Peter L Collins; Brian Murphy
Generation of a parainfluenza virus type 1 vaccine candidate by replacing the HN and F glycoproteins of the live-attenuated PIV3 cp45 vaccine virus with their PIV1 counterparts.
Vaccine 1999;18(5-6):503-10.
1999: Linda S Wyatt; S S Whitehead; K A Venanzi; Brian Murphy; Bernard Moss
Priming and boosting immunity to respiratory syncytial virus by recombinant replication-defective vaccinia virus MVA.
Vaccine 1999;18(5-6):392-7.
1999: Paul Auwaerter; P A Rota; W R Elkins; Robert J Adams; T DeLozier; Y Shi; William Joseph Bellini; Brian Murphy; Diane E Griffin
Measles virus infection in rhesus macaques: altered immune responses and comparison of the virulence of six different virus strains.
The Journal of infectious diseases 1999;180(4):950-8.
1999: Anna P Durbin; Josephine McAuliffe; Peter L Collins; Brian Murphy
Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates.
Virology 1999;261(2):319-30.
1999: Mario Skiadopoulos; Sonja R Surman; Marisa St Claire; William R Elkins; Peter L Collins; Brian Murphy
Attenuation of the recombinant human parainfluenza virus type 3 cp45 candidate vaccine virus is augmented by importation of the respiratory syncytial virus cpts530 L polymerase mutation.
Virology 1999;260(1):125-35.
1999: K Juhasz; Brian Murphy; Peter L Collins
The major attenuating mutations of the respiratory syncytial virus vaccine candidate cpts530/1009 specify temperature-sensitive defects in transcription and replication and a non-temperature-sensitive alteration in mRNA termination.
Journal of virology 1999;73(6):5176-80.
1999: Anna P Durbin; C J Cho; William R Elkins; LS Wyatt; Bernard Moss; Brian Murphy
Comparison of the immunogenicity and efficacy of a replication-defective vaccinia virus expressing antigens of human parainfluenza virus type 3 (HPIV3) with those of a live attenuated HPIV3 vaccine candidate in rhesus monkeys passively immunized with PIV3 antibodies.
The Journal of infectious diseases 1999;179(6):1345-51.
1999: Stephen S Whitehead; Alexander Bukreyev; Michael N Teng; Cai-Yen Firestone; Marisa St Claire; William R Elkins; Peter L Collins; Brian Murphy
Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees.
Journal of virology 1999;73(4):3438-42.
1999: K Juhasz; Stephen S Whitehead; C A Boulanger; Cai-Yen Firestone; Peter L Collins; Brian Murphy
The two amino acid substitutions in the L protein of cpts530/1009, a live-attenuated respiratory syncytial virus candidate vaccine, are independent temperature-sensitive and attenuation mutations.
Vaccine 1999;17(11-12):1416-24.
1999: T Tao; Mario Skiadopoulos; Anna P Durbin; F Davoodi; Peter L Collins; Brian Murphy
A live attenuated chimeric recombinant parainfluenza virus (PIV) encoding the internal proteins of PIV type 3 and the surface glycoproteins of PIV type 1 induces complete resistance to PIV1 challenge and partial resistance to PIV3 challenge.
Vaccine 1999;17(9-10):1100-8.
1999: Alexander Bukreyev; Stephen S Whitehead; N Bukreyeva; Brian Murphy; Peter L Collins
Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2367-72.
1999: Mario Skiadopoulos; Sonja R Surman; Joanne M Tatem; Maribel Paschalis; Shin-Lu Wu; S A Udem; Anna P Durbin; Peter L Collins; Brian Murphy
Identification of mutations contributing to the temperature-sensitive, cold-adapted, and attenuation phenotypes of the live-attenuated cold-passage 45 (cp45) human parainfluenza virus 3 candidate vaccine.
Journal of virology 1999;73(2):1374-81.
1999: Stephen S Whitehead; Cai-Yen Firestone; Ruth A Karron; James Crowe; William R Elkins; Peter L Collins; Brian Murphy
Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.
Journal of virology 1999;73(2):871-7.
1999: James Crowe; Valerie B Randolph; Brian Murphy
The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivo.
Virus research 1999;59(1):13-22.
1999: Peter L Collins; Stephen S Whitehead; Alexander Bukreyev; Rachel Fearns; Michael N Teng; K Juhasz; Robert M Chanock; Brian Murphy
Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics.
Advances in virus research 1999;54():423-51.
1998: James Crowe; Cai-Yen Firestone; Roberta L Crim; J A Beeler; Kathleen L Coelingh; C F Barbas; Dennis R Burton; Robert M Chanock; Brian Murphy
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.
Virology 1998;252(2):373-5.
1998: A L Reed; H Yamazaki; Joshua D Kaufman; Yaffa R Rubinstein; Brian Murphy; Alfred C Johnson
Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor.
The Journal of biological chemistry 1998;273(34):21594-602.
1998: Stephen S Whitehead; Cai-Yen Firestone; Peter L Collins; Brian Murphy
A single nucleotide substitution in the transcription start signal of the M2 gene of respiratory syncytial virus vaccine candidate cpts248/404 is the major determinant of the temperature-sensitive and attenuation phenotypes.
Virology 1998;247(2):232-9.
1998: Anna P Durbin; LS Wyatt; JW Siew; Bernard Moss; Brian Murphy
The immunogenicity and efficacy of intranasally or parenterally administered replication-deficient vaccinia-parainfluenza virus type 3 recombinants in rhesus monkeys.
Vaccine 1998;16(13):1324-30.
1998: Yaffa R Rubinstein; K N Proctor; Michael Bergel; Brian Murphy; Alfred C Johnson
Interferon regulatory factor-1 is a major regulator of epidermal growth factor receptor gene expression.
FEBS letters 1998;431(2):268-72.
1998: Stephen S Whitehead; K Juhasz; Cai-Yen Firestone; Peter L Collins; Brian Murphy
Recombinant respiratory syncytial virus (RSV) bearing a set of mutations from cold-passaged RSV is attenuated in chimpanzees.
Journal of virology 1998;72(5):4467-71.
1998: James Crowe; P S Gilmour; Brian Murphy; Robert M Chanock; L Duan; R J Pomerantz; Glenn Pilkington
Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo.
The Journal of infectious diseases 1998;177(4):1073-6.
1998: T Tao; Anna P Durbin; Stephen S Whitehead; F Davoodi; Peter L Collins; Brian Murphy
Recovery of a fully viable chimeric human parainfluenza virus (PIV) type 3 in which the hemagglutinin-neuraminidase and fusion glycoproteins have been replaced by those of PIV type 1.
Journal of virology 1998;72(4):2955-61.
1998: Mario Skiadopoulos; Anna P Durbin; Joanne M Tatem; Shin-Lu Wu; Maribel Paschalis; T Tao; Peter L Collins; Brian Murphy
Three amino acid substitutions in the L protein of the human parainfluenza virus type 3 cp45 live attenuated vaccine candidate contribute to its temperature-sensitive and attenuation phenotypes.
Journal of virology 1998;72(3):1762-8.
1997: Ruth A Karron; Deborah A Buonagurio; A F Georgiu; Stephen S Whitehead; J E Adamus; Mary Lou Clements-Mann; D O Harris; Valerie B Randolph; Stephen A Udem; Brian Murphy; Maninder Sidhu
Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13961-6.
1997: Ruth A Karron; Peter F Wright; James Crowe; Mary Lou Clements-Mann; Juliette Thompson; M Makhene; Roberta Casey; Brian Murphy
Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children.
The Journal of infectious diseases 1997;176(6):1428-36.
1997: Alexander Bukreyev; Stephen S Whitehead; Brian Murphy; Peter L Collins
Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse.
Journal of virology 1997;71(12):8973-82.
1997: Anna P Durbin; S L Hall; JW Siew; Stephen S Whitehead; Peter L Collins; Brian Murphy
Recovery of infectious human parainfluenza virus type 3 from cDNA.
Virology 1997;235(2):323-32.
1997: Brian Murphy; E J Park; P Gottlieb; Kanta Subbarao
An influenza A live attenuated reassortant virus possessing three temperature-sensitive mutations in the PB2 polymerase gene rapidly loses temperature sensitivity following replication in hamsters.
Vaccine 1997;15(12-13):1372-8.
1997: K Juhasz; Stephen S Whitehead; P T Bui; J M Biggs; James Crowe; C A Boulanger; Peter L Collins; Brian Murphy
The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.
Journal of virology 1997;71(8):5814-9.
1997: Anna P Durbin; JW Siew; Brian Murphy; Peter L Collins
Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six.
Virology 1997;234(1):74-83.
1997: Brian Murphy; Peter L Collins
Current status of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccine development: memorandum from a joint WHO/NIAID meeting.
Bulletin of the World Health Organization 1997;75(4):307-13.
1996: Cai-Yen Firestone; Stephen S Whitehead; Peter L Collins; Brian Murphy; James Crowe
Nucleotide sequence analysis of the respiratory syncytial virus subgroup A cold-passaged (cp) temperature sensitive (ts) cpts-248/404 live attenuated virus vaccine candidate.
Virology 1996;225(2):419-22.
1996: Linda S Wyatt; S T Shors; Brian Murphy; Bernard Moss
Development of a replication-deficient recombinant vaccinia virus vaccine effective against parainfluenza virus 3 infection in an animal model.
Vaccine 1996;14(15):1451-8.
1996: Ruth A Karron; M Makhene; K Gay; Modena E H Wilson; M L Clements; Brian Murphy
Evaluation of a live attenuated bovine parainfluenza type 3 vaccine in two- to six-month-old infants.
The Pediatric infectious disease journal 1996;15(8):650-4.
1996: James Crowe; P T Bui; Cai-Yen Firestone; M Connors; W R Elkins; Robert M Chanock; Brian Murphy
Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates.
The Journal of infectious diseases 1996;173(4):829-39.
1996: Hong Jin; K Subbarao; S Bagai; George P Leser; Brian Murphy; Robert A Lamb
Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity.
Journal of virology 1996;70(3):1406-14.
1996: James Crowe; Cai-Yen Firestone; Stephen S Whitehead; Peter L Collins; Brian Murphy
Acquisition of the ts phenotype by a chemically mutagenized cold-passaged human respiratory syncytial virus vaccine candidate results from the acquisition of a single mutation in the polymerase (L) gene.
Virus genes 1996;13(3):269-73.
1996: M L Clements; M K Makhene; Ruth A Karron; Brian Murphy; mark steinhoff; K Subbarao; Modena E H Wilson; Peter F Wright
Effective immunization with live attenuated influenza A virus can be achieved in early infancy. Pediatric Care Center.
The Journal of infectious diseases 1996;173(1):44-51.
1995: Peter L Collins; M G Hill; E Camargo; H Grosfeld; Robert M Chanock; Brian Murphy
Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11563-7.
1995: K Subbarao; R G Webster; Y Kawaoka; Brian Murphy
Are there alternative avian influenza viruses for generation of stable attenuated avian-human influenza A reassortant viruses?
Virus research 1995;39(2-3):105-18.
1995: Ruth A Karron; Peter F Wright; F K Newman; M Makhene; J Thompson; R Samorodin; Modena E H Wilson; E L Anderson; M L Clements; Brian Murphy
A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in healthy infants and children.
The Journal of infectious diseases 1995;172(6):1445-50.
1995: E K Subbarao; E J Park; C M Lawson; A Y Chen; Brian Murphy
Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine.
Journal of virology 1995;69(10):5969-77.
1995: X L Sun; Brian Murphy; Q J Li; S Gullapalli; J Mackins; Hiremagalur N Jayaram; Arun Srivastava; A C Antony
Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo.
The Journal of clinical investigation 1995;96(3):1535-47.
1995: Zina Moldoveanu; M L Clements; S J Prince; Brian Murphy; Jiri Mestecky
Human immune responses to influenza virus vaccines administered by systemic or mucosal routes.
Vaccine 1995;13(11):1006-12.
1995: James Crowe; P T Bui; G R Siber; W R Elkins; Robert M Chanock; Brian Murphy
Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization.
Vaccine 1995;13(9):847-55.
1995: M Connors; James Crowe; Cai-Yen Firestone; Brian Murphy; Peter L Collins
A cold-passaged, attenuated strain of human respiratory syncytial virus contains mutations in the F and L genes.
Virology 1995;208(2):478-84.
1995: K H Hsu; James Crowe; M D Lubeck; A R Davis; P P Hung; Robert M Chanock; Brian Murphy
Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus.
Vaccine 1995;13(5):509-15.
1995: A B Kulkarni; Peter L Collins; Igor Bacik; jon yewdell; Jack R Bennink; James Crowe; Brian Murphy
Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus.
Journal of virology 1995;69(2):1261-4.
1995: Ruth A Karron; mark steinhoff; E K Subbarao; Modena E H Wilson; K Macleod; M L Clements; L F Fries; Brian Murphy
Safety and immunogenicity of a cold-adapted influenza A (H1N1) reassortant virus vaccine administered to infants less than six months of age.
The Pediatric infectious disease journal 1995;14(1):10-6.
1994: J Treanor; M Perkins; R Battaglia; Brian Murphy
Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.
Journal of virology 1994;68(12):7684-8.
1994: James Crowe; P Y Cheung; E F Wallace; Robert M Chanock; J W Larrick; Brian Murphy; K Fry
Isolation and characterization of a chimpanzee monoclonal antibody to the G glycoprotein of human respiratory syncytial virus.
Clinical and diagnostic laboratory immunology 1994;1(6):701-6.
1994: M Connors; N A Giese; A B Kulkarni; Cai-Yen Firestone; Herbert C Morse; Brian Murphy
Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10.
Journal of virology 1994;68(8):5321-5.
1994: James Crowe; P T Bui; A R Davis; Robert M Chanock; Brian Murphy
A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees.
Vaccine 1994;12(9):783-90.
1994: James Crowe; P T Bui; W T London; A R Davis; P P Hung; Robert M Chanock; Brian Murphy
Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis.
Vaccine 1994;12(8):691-9.
1994: C M Lawson; Jack R Bennink; Nicholas P Restifo; jon yewdell; Brian Murphy
Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge.
Journal of virology 1994;68(6):3505-11.
1994: Brian Murphy; S L Hall; A B Kulkarni; James Crowe; Peter L Collins; M Connors; Ruth A Karron; Robert M Chanock
An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines.
Virus research 1994;32(1):13-36.
1994: James Crowe; Brian Murphy; Robert M Chanock; R Anthony Williamson; Carlos F Barbas; Dennis R Burton
Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1386-90.
1993: E K Subbarao; Y Kawaoka; Brian Murphy
Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.
Journal of virology 1993;67(12):7223-8.
1993: James Crowe; Peter L Collins; W T London; Robert M Chanock; Brian Murphy
A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV.
Vaccine 1993;11(14):1395-404.
1993: A Stokes; E L Tierney; C M Sarris; Brian Murphy; S L Hall
The complete nucleotide sequence of two cold-adapted, temperature-sensitive attenuated mutant vaccine viruses (cp12 and cp45) derived from the JS strain of human parainfluenza virus type 3 (PIV3).
Virus research 1993;30(1):43-52.
1993: A B Kulkarni; Herbert C Morse; Jack R Bennink; jon yewdell; Brian Murphy
Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells.
Journal of virology 1993;67(7):4086-92.
1993: Suzanne L Epstein; Julia A Misplon; C M Lawson; E K Subbarao; M Connors; Brian Murphy
Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5484-93.
1993: Robert M Chanock; James Crowe; Brian Murphy; Dennis R Burton
Human monoclonal antibody Fab fragments cloned from combinatorial libraries: potential usefulness in prevention and/or treatment of major human viral diseases.
Infectious agents and disease 1993;2(3):118-31.
1993: T M de Sierra; Mary L Kumar; T E Wasser; Brian Murphy; E K Subbarao
Respiratory syncytial virus-specific immunoglobulins in preterm infants.
The Journal of pediatrics 1993;122(5 Pt 1):787-91.
1993: mark steinhoff; L F Fries; Ruth A Karron; M L Clements; Brian Murphy
Effect of heterosubtypic immunity on infection with attenuated influenza A virus vaccines in young children.
Journal of clinical microbiology 1993;31(4):836-8.
1993: E K Subbarao; W London; Brian Murphy
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.
Journal of virology 1993;67(4):1761-4.
1993: S L Hall; C M Sarris; E L Tierney; W T London; Brian Murphy
A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees.
The Journal of infectious diseases 1993;167(4):958-62.
1993: A B Kulkarni; M Connors; Cai-Yen Firestone; Herbert C Morse; Brian Murphy
The cytolytic activity of pulmonary CD8+ lymphocytes, induced by infection with a vaccinia virus recombinant expressing the M2 protein of respiratory syncytial virus (RSV), correlates with resistance to RSV infection in mice.
Journal of virology 1993;67(2):1044-9.
1992: M Connors; A B Kulkarni; Cai-Yen Firestone; K L Holmes; Herbert C Morse; A V Sotnikov; Brian Murphy
Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells.
Journal of virology 1992;66(12):7444-51.
1992: C M Lawson; E K Subbarao; Brian Murphy
Nucleotide sequence changes in the polymerase basic protein 2 gene of temperature-sensitive mutants of influenza A virus.
Virology 1992;191(1):506-10.
1992: Carlos F Barbas; James Crowe; D Cababa; T M Jones; S L Zebedee; Brian Murphy; Robert M Chanock; Dennis R Burton
Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10164-8.
1992: K H Hsu; M D Lubeck; A R Davis; Ramesh A Bhat; B H Selling; Bheem Bhat; S Mizutani; Brian Murphy; P L Collins; Robert M Chanock
Immunogenicity of recombinant adenovirus-respiratory syncytial virus vaccines with adenovirus types 4, 5, and 7 vectors in dogs and a chimpanzee.
The Journal of infectious diseases 1992;166(4):769-75.
1992: E K Subbarao; Mark Perkins; J J Treanor; Brian Murphy
The attenuation phenotype conferred by the M gene of the influenza A/Ann Arbor/6/60 cold-adapted virus (H2N2) on the A/Korea/82 (H3N2) reassortant virus results from a gene constellation effect.
Virus research 1992;25(1-2):37-50.
1992: A Stokes; E L Tierney; Brian Murphy; S L Hall
The complete nucleotide sequence of the JS strain of human parainfluenza virus type 3: comparison with the Wash/47885/57 prototype strain.
Virus research 1992;25(1-2):91-103.
1992: Robert M Chanock; R H Parrott; M Connors; Peter L Collins; Brian Murphy
Serious respiratory tract disease caused by respiratory syncytial virus: prospects for improved therapy and effective immunization.
Pediatrics 1992;90(1 Pt 2):137-43.
1992: E K Subbarao; Y Kawaoka; K Ryan-Poirier; M L Clements; Brian Murphy
Comparison of different approaches to measuring influenza A virus-specific hemagglutination inhibition antibodies in the presence of serum inhibitors.
Journal of clinical microbiology 1992;30(4):996-9.
1992: M L Clements; E K Subbarao; L F Fries; Ruth A Karron; W T London; Brian Murphy
Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.
Journal of clinical microbiology 1992;30(3):655-62.
1992: S L Hall; A Stokes; E L Tierney; W T London; Robert B Belshe; F C Newman; Brian Murphy
Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys.
Virus research 1992;22(3):173-84.
1992: D C Powers; Brian Murphy; L F Fries; W H Adler; M L Clements
Reduced infectivity of cold-adapted influenza A H1N1 viruses in the elderly: correlation with serum and local antibodies.
Journal of the American Geriatrics Society 1992;40(2):163-7.
1992: M Connors; A B Kulkarni; Peter L Collins; Cai-Yen Firestone; K L Holmes; Herbert C Morse; Brian Murphy
Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies.
Journal of virology 1992;66(2):1277-81.
1992: M Connors; Peter L Collins; Cai-Yen Firestone; A V Sotnikov; A Waitze; A R Davis; P P Hung; Robert M Chanock; Brian Murphy
Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia--RSV recombinants or RSV.
Vaccine 1992;10(7):475-84.
1992: E K Subbarao; Brian Murphy
A general overview of viral vaccine development.
Advances in experimental medicine and biology 1992;327():51-8.
1991: S L Hall; Brian Murphy; K L van Wyke Coelingh
Protection of cotton rats by immunization with the human parainfluenza virus type 3 fusion (F) glycoprotein expressed on the surface of insect cells infected with a recombinant baculovirus.
Vaccine 1991;9(9):659-67.
1991: John Treanor; R Buja; Brian Murphy
Intragenic suppression of a deletion mutation of the nonstructural gene of an influenza A virus.
Journal of virology 1991;65(8):4204-10.
1991: P M Muelenaer; Frederick W Henderson; Val G Hemming; E E Walsh; L J Anderson; G A Prince; Brian Murphy
Group-specific serum antibody responses in children with primary and recurrent respiratory syncytial virus infections.
The Journal of infectious diseases 1991;164(1):15-21.
1991: J J Treanor; E L Tierney; W T London; Brian Murphy
Characterization of the attenuating M and NP gene segments of the avian influenza A/Mallard/78 virus during in vitro production of avian-human reassortant vaccine viruses and after replication in humans and primates.
Vaccine 1991;9(7):495-501.
1991: Thomas Muster; E K Subbarao; M Enami; Brian Murphy; Peter Palese
An influenza A virus containing influenza B virus 5' and 3' noncoding regions on the neuraminidase gene is attenuated in mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5177-81.
1991: M L Clements; Robert B Belshe; James C King; F Newman; T U Westblom; E L Tierney; W T London; Brian Murphy
Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees.
Journal of clinical microbiology 1991;29(6):1175-82.
1991: mark steinhoff; Neal A Halsey; L F Fries; Modena E H Wilson; James C King; B A Burns; R K Samorodin; V Perkis; Brian Murphy; M L Clements
The A/Mallard/6750/78 avian-human, but not the A/Ann Arbor/6/60 cold-adapted, influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine retains partial virulence for infants and children.
The Journal of infectious diseases 1991;163(5):1023-8.
1991: Kathryn M Edwards; James C King; mark steinhoff; Juliette Thompson; M L Clements; Peter F Wright; Brian Murphy
Safety and immunogenicity of live attenuated cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in infants and children.
The Journal of infectious diseases 1991;163(4):740-5.
1991: Brian Murphy; G A Prince; Peter L Collins; S W Hildreth; Peter Paradiso
Effect of passive antibody on the immune response of cotton rats to purified F and G glycoproteins of respiratory syncytial virus (RSV).
Vaccine 1991;9(3):185-9.
1991: D C Powers; L F Fries; Brian Murphy; Bhagvanji Thumar; M L Clements
In elderly persons live attenuated influenza A virus vaccines do not offer an advantage over inactivated virus vaccine in inducing serum or secretory antibodies or local immunologic memory.
Journal of clinical microbiology 1991;29(3):498-505.
1991: M Connors; Peter L Collins; Cai-Yen Firestone; Brian Murphy
Respiratory syncytial virus (RSV) F, G, M2 (22K), and N proteins each induce resistance to RSV challenge, but resistance induced by M2 and N proteins is relatively short-lived.
Journal of virology 1991;65(3):1634-7.
1991: T Kanesaki; Brian Murphy; P L Collins; P L Ogra
Effectiveness of enteric immunization in the development of secretory immunoglobulin A response and the outcome of infection with respiratory syncytial virus.
Journal of virology 1991;65(2):657-63.
1990: Brian Murphy; A V Sotnikov; L A Lawrence; S M Banks; G A Prince
Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization.
Vaccine 1990;8(5):497-502.
1990: mark steinhoff; Neal A Halsey; Modena E H Wilson; B A Burns; R K Samorodin; L F Fries; Brian Murphy; M L Clements
Comparison of live attenuated cold-adapted and avian-human influenza A/Bethesda/85 (H3N2) reassortant virus vaccines in infants and children.
The Journal of infectious diseases 1990;162(2):394-401.
1990: K L van Wyke Coelingh; C C Winter; E L Tierney; S L Hall; W T London; H W Kim; Robert M Chanock; Brian Murphy
Antibody responses of humans and nonhuman primates to individual antigenic sites of the hemagglutinin-neuraminidase and fusion glycoproteins after primary infection or reinfection with parainfluenza type 3 virus.
Journal of virology 1990;64(8):3833-43.
1990: Brian Murphy; G A Prince; L A Lawrence; K D Croen; Peter L Collins
Detection of respiratory syncytial virus (RSV) infected cells by in situ hybridization in the lungs of cotton rats immunized with formalin-inactivated virus or purified RSV F and G glycoprotein subunit vaccine and challenged with RSV.
Virus research 1990;16(2):153-62.
1990: Gregory A Prince; Val G Hemming; R L Horswood; P A Baron; Brian Murphy; R M Chanock
Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats.
Journal of virology 1990;64(6):3091-2.
1990: M L Clements; M H Snyder; S D Sears; H F Maassab; Brian Murphy
Evaluation of the infectivity, immunogenicity, and efficacy of live cold-adapted influenza B/Ann Arbor/1/86 reassortant virus vaccine in adult volunteers.
The Journal of infectious diseases 1990;161(5):869-77.
1990: Peter L Collins; Robert Purcell; W T London; L A Lawrence; Robert M Chanock; Brian Murphy
Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus.
Vaccine 1990;8(2):164-8.
1990: J J Treanor; E L Tierney; S L Zebedee; R A Lamb; Brian Murphy
Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
Journal of virology 1990;64(3):1375-7.
1990: Charles Flexner; Bernard Moss; W T London; Brian Murphy
Attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2.
Vaccine 1990;8(1):17-21.
1990: M H Snyder; W T London; H F Maassab; Robert M Chanock; Brian Murphy
A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype.
Virus research 1990;15(1):69-83.
1989: Brian Murphy; A Sotnikov; Peter Paradiso; S W Hildreth; A B Jenson; R B Baggs; L Lawrence; J J Zubak; Robert M Chanock; J A Beeler
Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV disease.
Vaccine 1989;7(6):533-40.
1989: Brian Murphy; A J Buckler-White; W T London; M H Snyder
Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys.
Vaccine 1989;7(6):557-61.
1989: D C Powers; S D Sears; Brian Murphy; Bhagvanji Thumar; M L Clements
Systemic and local antibody responses in elderly subjects given live or inactivated influenza A virus vaccines.
Journal of clinical microbiology 1989;27(12):2666-71.
1989: M H Snyder; W T London; H F Maassab; Brian Murphy
Attenuation and phenotypic stability of influenza B/Texas/1/84 cold-adapted reassortant virus: studies in hamsters and chimpanzees.
The Journal of infectious diseases 1989;160(4):604-10.
1989: M W Wathen; R J Brideau; Darrell R Thomsen; Brian Murphy
Characterization of a novel human respiratory syncytial virus chimeric FG glycoprotein expressed using a baculovirus vector.
The Journal of general virology 1989;70 ( Pt 10)():2625-35.
1989: Brian Murphy; Peter L Collins; L Lawrence; J Zubak; Robert M Chanock; G A Prince
Immunosuppression of the antibody response to respiratory syncytial virus (RSV) by pre-existing serum antibodies: partial prevention by topical infection of the respiratory tract with vaccinia virus-RSV recombinants.
The Journal of general virology 1989;70 ( Pt 8)():2185-90.
1989: J J Treanor; M H Snyder; W T London; Brian Murphy
The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys.
Virology 1989;171(1):1-9.
1989: D K Wagner; P Muelenaer; Frederick W Henderson; M H Snyder; C B Reimer; E E Walsh; L J Anderson; David L Nelson; Brian Murphy
Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections.
Journal of clinical microbiology 1989;27(3):589-92.
1989: M L Clements; S D Sears; K Christina; Brian Murphy; M H Snyder
Comparison of the virologic and immunologic responses of volunteers to live avian-human influenza A H3N2 reassortant virus vaccines derived from two different avian influenza virus donors.
Journal of clinical microbiology 1989;27(1):219-22.
1989: Brian Murphy; M L Clements
The systemic and mucosal immune response of humans to influenza A virus.
Current topics in microbiology and immunology 1989;146():107-16.
1989: R A Olmsted; Brian Murphy; L A Lawrence; N Elango; Bernard Moss; Peter L Collins
Processing, surface expression, and immunogenicity of carboxy-terminally truncated mutants of G protein of human respiratory syncytial virus.
Journal of virology 1989;63(1):411-20.
1988: S D Sears; M L Clements; R F Betts; H F Maassab; Brian Murphy; M H Snyder
Comparison of live, attenuated H1N1 and H3N2 cold-adapted and avian-human influenza A reassortant viruses and inactivated virus vaccine in adults.
The Journal of infectious diseases 1988;158(6):1209-19.
1988: R A Olmsted; R M Buller; Peter L Collins; W T London; J A Beeler; G A Prince; Robert M Chanock; Brian Murphy
Evaluation in non-human primates of the safety, immunogenicity and efficacy of recombinant vaccinia viruses expressing the F or G glycoprotein of respiratory syncytial virus.
Vaccine 1988;6(6):519-24.
1988: S Vasantha; Kathleen L Coelingh; Brian Murphy; R R Dourmashkin; C H Hammer; Michael M Frank; L F Fries
Interactions of a nonneutralizing IgM antibody and complement in parainfluenza virus neutralization.
Virology 1988;167(2):433-41.
1988: Robert F Betts; R G Douglas; Hussein Maassab; D C DeBorde; M L Clements; Brian Murphy
Analysis of virus and host factors in a study of A/Peking/2/79 (H3N2) cold-adapted vaccine recombinant in which vaccine-associated illness occurred in normal volunteers.
Journal of medical virology 1988;26(2):175-83.
1988: M H Snyder; S Banks; Brian Murphy
Determination of antibody response to influenza virus surface glycoproteins by kinetic enzyme-linked immunosorbent assay.
Journal of clinical microbiology 1988;26(10):2034-40.
1988: Brian Murphy; R A Olmsted; Peter L Collins; Robert M Chanock; G A Prince
Passive transfer of respiratory syncytial virus (RSV) antiserum suppresses the immune response to the RSV fusion (F) and large (G) glycoproteins expressed by recombinant vaccinia viruses.
Journal of virology 1988;62(10):3907-10.
1988: Charles Flexner; Brian Murphy; J F Rooney; C Wohlenberg; V Yuferov; Abner Louis Notkins; Bernard Moss
Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen.
Nature 1988;335(6187):259-62.
1988: Brian Murphy; G A Prince; Peter L Collins; K Van Wyke Coelingh; R A Olmsted; M K Spriggs; R H Parrott; H W Kim; C D Brandt; Robert M Chanock
Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses.
Virus research 1988;11(1):1-15.
1988: Brian Murphy; E E Walsh
Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity.
Journal of clinical microbiology 1988;26(8):1595-7.
1988: Robert M Chanock; Brian Murphy; Peter L Collins; K V Coelingh; R A Olmsted; M H Snyder; M K Spriggs; G A Prince; Bernard Moss; J Flores
Live viral vaccines for respiratory and enteric tract diseases.
Vaccine 1988;6(2):129-33.
1988: M K Spriggs; Peter L Collins; E Tierney; W T London; Brian Murphy
Immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (PIV3) protects patas monkeys against PIV3 infection.
Journal of virology 1988;62(4):1293-6.
1988: K L van Wyke Coelingh; C C Winter; E L Tierney; W T London; Brian Murphy
Attenuation of bovine parainfluenza virus type 3 in nonhuman primates and its ability to confer immunity to human parainfluenza virus type 3 challenge.
The Journal of infectious diseases 1988;157(4):655-62.
1988: M H Snyder; R F Betts; D DeBorde; E L Tierney; M L Clements; D Herrington; S D Sears; R Dolin; H F Maassab; Brian Murphy
Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.
Journal of virology 1988;62(2):488-95.
1988: Brian Murphy
Current approaches to the development of vaccines effective against parainfluenza viruses.
Bulletin of the World Health Organization 1988;66(3):391-7.
1988: K L van Wyke Coelingh; C C Winter; Brian Murphy
Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983.
Virology 1988;162(1):137-43.
1987: M K Spriggs; Brian Murphy; G A Prince; R A Olmsted; Peter L Collins
Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity.
Journal of virology 1987;61(11):3416-23.
1987: P R Johnson; R A Olmsted; G A Prince; Brian Murphy; D W Alling; E E Walsh; Peter L Collins
Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity.
Journal of virology 1987;61(10):3163-6.
1987: K L van Wyke Coelingh; Brian Murphy; Peter L Collins; A M Lebacq-Verheyden; James F Battey
Expression of biologically active and antigenically authentic parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein by a recombinant baculovirus.
Virology 1987;160(2):465-72.
1987: M H Snyder; A J Buckler-White; W T London; E L Tierney; Brian Murphy
The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys.
Journal of virology 1987;61(9):2857-63.
1987: R G Paterson; R A Lamb; Bernard Moss; Brian Murphy
Comparison of the relative roles of the F and HN surface glycoproteins of the paramyxovirus simian virus 5 in inducing protective immunity.
Journal of virology 1987;61(6):1972-7.
1987: K L van Wyke Coelingh; C C Winter; E D Jorgensen; Brian Murphy
Antigenic and structural properties of the hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3: sequence analysis of variants selected with monoclonal antibodies which inhibit infectivity, hemagglutination, and neuraminidase activities.
Journal of virology 1987;61(5):1473-7.
1987: D K Wagner; David L Nelson; E E Walsh; C B Reimer; Frederick W Henderson; Brian Murphy
Differential immunoglobulin G subclass antibody titers to respiratory syncytial virus F and G glycoproteins in adults.
Journal of clinical microbiology 1987;25(4):748-50.
1987: D K Wagner; M L Clements; C B Reimer; M Snyder; David L Nelson; Brian Murphy
Analysis of immunoglobulin G antibody responses after administration of live and inactivated influenza A vaccine indicates that nasal wash immunoglobulin G is a transudate from serum.
Journal of clinical microbiology 1987;25(3):559-62.
1987: T A Brown; M L Clements; Brian Murphy; J Radl; J J Haaijman; J Mestecky
Molecular form and subclass distribution of IgA antibodies after immunization with live and inactivated influenza A vaccines.
Advances in experimental medicine and biology 1987;216B():1691-700.
1986: A J Buckler-White; Brian Murphy
Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins.
Virology 1986;155(2):345-55.
1986: Brian Murphy; D W Alling; M H Snyder; E E Walsh; G A Prince; Robert M Chanock; Val G Hemming; W J Rodriguez; H W Kim; B S Graham
Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection.
Journal of clinical microbiology 1986;24(5):894-8.
1986: M H Snyder; E H Stephenson; H Young; C G York; E L Tierney; W T London; Robert M Chanock; Brian Murphy
Infectivity and antigenicity of live avian-human influenza A reassortant virus: comparison of intranasal and aerosol routes in squirrel monkeys.
The Journal of infectious diseases 1986;154(4):709-11.
1986: R A Olmsted; N Elango; G A Prince; Brian Murphy; P R Johnson; Bernard Moss; Robert M Chanock; Peter L Collins
Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7462-6.
1986: K J Coelingh; C C Winter; Brian Murphy; J M Rice; P C Kimball; R A Olmsted; P L Collins
Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies.
Journal of virology 1986;60(1):90-6.
1986: M H Snyder; M L Clements; D Herrington; W T London; E L Tierney; Brian Murphy
Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors.
Journal of clinical microbiology 1986;24(3):467-9.
1986: D K Wagner; B S Graham; P F Wright; E E Walsh; H W Kim; C B Reimer; David L Nelson; Robert M Chanock; Brian Murphy
Serum immunoglobulin G antibody subclass responses to respiratory syncytial virus F and G glycoproteins after primary infection.
Journal of clinical microbiology 1986;24(2):304-6.
1986: Brian Murphy; G A Prince; E E Walsh; H W Kim; R H Parrott; Val G Hemming; WJ Rodriguez; R M Chanock
Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine.
Journal of clinical microbiology 1986;24(2):197-202.
1986: M H Snyder; W T London; E L Tierney; H F Maassab; Brian Murphy
Restricted replication of a cold-adapted reassortant influenza A virus in the lower respiratory tract of chimpanzees.
The Journal of infectious diseases 1986;154(2):370-1.
1986: M L Clements; M H Snyder; A J Buckler-White; E L Tierney; W T London; Brian Murphy
Evaluation of avian-human reassortant influenza A/Washington/897/80 x A/Pintail/119/79 virus in monkeys and adult volunteers.
Journal of clinical microbiology 1986;24(1):47-51.
1986: M L Clements; R F Betts; E L Tierney; Brian Murphy
Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus.
Journal of clinical microbiology 1986;24(1):157-60.
1986: Brian Murphy; B S Graham; G A Prince; E E Walsh; R M Chanock; D T Karzon; P F Wright
Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection.
Journal of clinical microbiology 1986;23(6):1009-14.
1986: M H Snyder; M L Clements; R F Betts; R Dolin; A J Buckler-White; E L Tierney; Brian Murphy
Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers.
Journal of clinical microbiology 1986;23(5):852-7.
1986: N Elango; G A Prince; Brian Murphy; S Venkatesan; Robert M Chanock; Bernard Moss
Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1906-10.
1986: Gregory A Prince; A B Jenson; Val G Hemming; Brian Murphy; E E Walsh; R L Horswood; R M Chanock
Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus.
Journal of virology 1986;57(3):721-8.
1986: A J Buckler-White; C W Naeve; Brian Murphy
Characterization of a gene coding for M proteins which is involved in host range restriction of an avian influenza A virus in monkeys.
Journal of virology 1986;57(2):697-700.
1986: S F Tian; A J Buckler-White; W T London; L J Reck; Robert M Chanock; Brian Murphy
[Nucleoprotein and membrane protein genes responsible for restriction of replication of influenza A/Mallard/NY/78 virus and its reassortants in the respiratory tract of squirrel monkeys].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 1986;8(1):1-6.
1986: M L Clements; R F Betts; E L Tierney; Brian Murphy
Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine.
Journal of clinical microbiology 1986;23(1):73-6.
1986: M L Clements; Brian Murphy
Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine.
Journal of clinical microbiology 1986;23(1):66-72.
1985: M H Snyder; M L Clements; D De Borde; H F Maassab; Brian Murphy
Attenuation of wild-type human influenza A virus by acquisition of the PA polymerase and matrix protein genes of influenza A/Ann Arbor/6/60 cold-adapted donor virus.
Journal of clinical microbiology 1985;22(5):719-25.
1985: Val G Hemming; Gregory A Prince; R L Horswood; W J London; Brian Murphy; E E Walsh; G W Fischer; L E Weisman; P A Baron; R M Chanock
Studies of passive immunotherapy for infections of respiratory syncytial virus in the respiratory tract of a primate model.
The Journal of infectious diseases 1985;152(5):1083-7.
1985: T A Brown; Brian Murphy; J Radl; J J Haaijman; J Mestecky
Subclass distribution and molecular form of immunoglobulin A hemagglutinin antibodies in sera and nasal secretions after experimental secondary infection with influenza A virus in humans.
Journal of clinical microbiology 1985;22(2):259-64.
1985: L P Van Voris; Robert F Betts; M A Menegus; Brian Murphy; F K Roth; R G Douglas
Serological diagnosis of influenza A/USSR/77 H1N1 infection: value of ELISA compared to other antibody techniques.
Journal of medical virology 1985;16(4):315-20.
1985: Brian Murphy; M L Clements; E L Tierney; Robert E Black; J Stienberg; R M Chanock
Dose response of influenza A/Washington/897/80 (H3N2) avian-human reassortant virus in adult volunteers.
The Journal of infectious diseases 1985;152(1):225-9.
1985: M L Clements; E L Tierney; Brian Murphy
Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine.
Journal of clinical microbiology 1985;21(6):997-9.
1985: K L van Wyke Coelingh; C Winter; Brian Murphy
Antigenic variation in the hemagglutinin-neuraminidase protein of human parainfluenza type 3 virus.
Virology 1985;143(2):569-82.
1985: D B Burlington; P F Wright; K L van Wyke; M A Phelan; R E Mayner; Brian Murphy
Development of subtype-specific and heterosubtypic antibodies to the influenza A virus hemagglutinin after primary infection in children.
Journal of clinical microbiology 1985;21(5):847-9.
1985: R F Betts; R G Douglas; Brian Murphy
Resistance to challenge with influenza A/Hong Kong/123/77 (H1N1) wild-type virus induced by live attenuated A/Hong Kong/123/77 (H1N1) cold-adapted reassortant virus.
The Journal of infectious diseases 1985;151(4):744-5.
1985: S F Tian; A J Buckler-White; W T London; L J Reck; Robert M Chanock; Brian Murphy
Nucleoprotein and membrane protein genes are associated with restriction of replication of influenza A/Mallard/NY/78 virus and its reassortants in squirrel monkey respiratory tract.
Journal of virology 1985;53(3):771-5.
1984: Brian Murphy; A J Buckler-White; W T London; J Harper; E L Tierney; N T Miller; L J Reck; Robert M Chanock; V S Hinshaw
Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses.
The Journal of infectious diseases 1984;150(6):841-50.
1984: S F Tian; L X Zhang; Brian Murphy
Characterization of the genotype and level of attenuation of an influenza A reassortant virus produced by mating the Xia-ts donor virus with A/Beijing/70 (H1N1) wild type virus.
Vaccine 1984;2(3):189-92.
1984: Brian Murphy; M L Clements; H P Madore; J Steinberg; S O'Donnell; R Betts; D Demico; R C Reichman; R Dolin; H F Maassab
Dose response of cold-adapted, reassortant influenza A/California/10/78 virus (H1N1) in adult volunteers.
The Journal of infectious diseases 1984;149(5):816.
1984: M L Clements; R F Betts; H F Maassab; Brian Murphy
Dose response of influenza A/Washington/897/80 (H3N2) cold-adapted reassortant virus in adult volunteers.
The Journal of infectious diseases 1984;149(5):814-5.
1984: M L Clements; R F Betts; Brian Murphy
Advantage of live attenuated cold-adapted influenza A virus over inactivated vaccine for A/Washington/80 (H3N2) wild-type virus infection.
Lancet 1984;1(8379):705-8.
1984: K L van Wyke; jon yewdell; L J Reck; Brian Murphy
Antigenic characterization of influenza A virus matrix protein with monoclonal antibodies.
Journal of virology 1984;49(1):248-52.
1983: G L Smith; Brian Murphy; Bernard Moss
Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7155-9.
1983: Brian Murphy; J Harper; D L Sly; W T London; N T Miller; R G Webster
Evaluation of the A/Seal/Mass/1/80 virus in squirrel monkeys.
Infection and immunity 1983;42(1):424-6.
1983: D B Burlington; M L Clements; G Meiklejohn; M Phelan; Brian Murphy
Hemagglutinin-specific antibody responses in immunoglobulin G, A, and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus.
Infection and immunity 1983;41(2):540-5.
1983: V S Hinshaw; R G Webster; C W Naeve; Brian Murphy
Altered tissue tropism of human-avian reassortant influenza viruses.
Virology 1983;128(1):260-3.
1983: P F Wright; Brian Murphy; M Kervina; E M Lawrence; M A Phelan; D T Karzon
Secretory immunological response after intranasal inactivated influenza A virus vaccinations: evidence for immunoglobulin A memory.
Infection and immunity 1983;40(3):1092-5.
1983: M L Clements; S O'Donnell; Myron M Levine; R M Chanock; Brian Murphy
Dose response of A/Alaska/6/77 (H3N2) cold-adapted reassortant vaccine virus in adult volunteers: role of local antibody in resistance to infection with vaccine virus.
Infection and immunity 1983;40(3):1044-51.
1983: K Shimizu; M G Mullinix; R M Chanock; Brian Murphy
Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. III. Genetic analysis of temperature-dependent host range mutants.
Virology 1983;124(1):35-44.
1982: Brian Murphy; D L Sly; E L Tierney; N T Hosier; J G Massicot; W T London; R M Chanock; R G Webster; V S Hinshaw
Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys.
Science (New York, N.Y.) 1982;218(4579):1330-2.
1982: T E Hobbins; T P Hughes; Margaret B Rennels; Brian Murphy; Myron M Levine
Bronchial reactivity in experimental infections with influenza virus.
The Journal of infectious diseases 1982;146(4):468-71.
1982: Brian Murphy; V S Hinshaw; D L Sly; W T London; N T Hosier; F T Wood; R G Webster; R M Chanock
Virulence of avian influenza A viruses for squirrel monkeys.
Infection and immunity 1982;37(3):1119-26.
1982: Brian Murphy; L J Markoff; N T Hosier; J G Massicot; R M Chanock
Production and level of genetic stability of an influenza A virus temperature-sensitive mutant containing two genes with ts mutations.
Infection and immunity 1982;37(1):235-42.
1982: Brian Murphy; D L Nelson; P F Wright; E L Tierney; M A Phelan; R M Chanock
Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines.
Infection and immunity 1982;36(3):1102-8.
1982: L J Brundage-Anguish; D F Holmes; N T Hosier; Brian Murphy; J G Massicott; G Appleyard; L Coggins
Live temperature-sensitive equine influenza virus vaccine: generation of the virus and efficacy in hamsters.
American journal of veterinary research 1982;43(5):869-74.
1982: M D Tolpin; M L Clements; Myron M Levine; Robert E Black; A J Saah; WILLIAM ANTHONY; L Cisneros; R M Chanock; Brian Murphy
Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant viruses.
Infection and immunity 1982;36(2):645-50.
1982: J G Massicot; K Van Wyke; R M Chanock; Brian Murphy
Evidence for intrasegmental complementation between two influenza A viruses having ts mutations on their P1 genes.
Virology 1982;117(2):496-500.
1982: K Shimizu; M G Mullinix; R M Chanock; Brian Murphy
Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. II. Genetic analysis and demonstration of intrasegmental complementation.
Virology 1982;117(1):45-61.
1982: K Shimizu; M G Mullinix; R M Chanock; Brian Murphy
Temperature-sensitive mutants of influenza A/Udorn/72 (H3N2) virus. I. Isolation of temperature-sensitive mutants some of which exhibit host-dependent temperature sensitivity.
Virology 1982;117(1):38-44.
1981: R Yarchoan; Brian Murphy; W Strober; H S Schneider; D L Nelson
Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(6):2588-94.
1981: R Yarchoan; Brian Murphy; W Strober; M L Clements; D L Nelson
In vitro production of anti-influenza virus antibody after intranasal inoculation with cold-adapted influenza virus.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(5):1958-63.
1981: M D Tolpin; J G Massicot; M G Mullinix; H W Kim; R H Parrott; R M Chanock; Brian Murphy
Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-ts-1A2 recombinant during growth in vivo.
Virology 1981;112(2):505-17.
1981: Brian Murphy; H F Maassab; F T Wood; R M Chanock
Characterization of the temperature sensitive phenotype of the A/Ann Arbor/6/60 cold-adapted virus and its recombinants.
Infection and immunity 1981;32(2):960-3.
1981: Brian Murphy; R M Chanock; M L Clements; WILLIAM ANTHONY; A J Sear; L A Cisneros; Margaret B Rennels; E H Miller; Robert E Black; Myron M Levine; R F Betts; R G Douglas; H F Maassab; N J Cox; A P Kendal
Evaluation of A/Alaska/6/77 (H3N2) cold-adapted recombinant viruses derived from A/Ann Arbor/6/60 cold-adapted donor virus in adult seronegative volunteers.
Infection and immunity 1981;32(2):693-7.
1981: Brian Murphy; M A Phelan; D L Nelson; R Yarchoan; E L Tierney; D W Alling; R M Chanock
Hemagglutinin-specific enzyme-linked immunosorbent assay for antibodies to influenza A and B viruses.
Journal of clinical microbiology 1981;13(3):554-60.
1980: J G Massicot; Brian Murphy; K van Wyke; K Y Huang; R M Chanock
ts P1 and P3 genes are responsible for satisfactory level of attenuation of ts-1A2 recombinants bearing H1N1 or H3N2 surface antigens of influenza A virus.
Virology 1980;106(1):187-90.
1980: Robert H Yolken; V M Torsch; R Berg; Brian Murphy; Y C Lee
Fluorometric assay for measurement of viral neuraminidase--application to the rapid detection of influenza virus in nasal wash specimens.
The Journal of infectious diseases 1980;142(4):516-23.
1980: Brian Murphy; Margaret B Rennels; R G Douglas; R F Betts; Robert B Couch; Thomas R Cate; R M Chanock; A P Kendal; H F Maassab; S Suwanagool; S B Sotman; L A Cisneros; WILLIAM ANTHONY; D R Nalin; Myron M Levine
Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers.
Infection and immunity 1980;29(2):348-55.
1980: Brian Murphy; E L Tierney; B A Barbour; Robert H Yolken; D W Alling; H P Holley; R E Mayner; R M Chanock
Use of the enzyme-linked immunosorbent assay to detect serum antibody responses of volunteers who received attenuated influenza A virus vaccines.
Infection and immunity 1980;29(2):342-7.
1980: Brian Murphy; N T Hosier; R M Chanock
Temperature-sensitive mutants of influenza A virus: transfer of the two temperature-sensitive lesions in the Udorn/72-ts-1A2 virus to the A2Hong Kong/123/77 (H1N1) wild-type virus.
Infection and immunity 1980;28(3):792-8.
1980: Brian Murphy; D L Sly; N T Hosier; W T London; R M Chanock
Evaluation of three strains of influenza A virus in humans and in owl, cebus, and squirrel monkeys.
Infection and immunity 1980;28(3):688-91.
1980: R M Chanock; Brian Murphy
Use of temperature-sensitive and cold-adapted mutant viruses in immunoprophylaxis of acute respiratory tract disease.
Reviews of infectious diseases 1980;2(3):421-32.
1980: R A Berg; Robert H Yolken; S I Rennard; R Dolin; Brian Murphy; S E Straus
New enzyme immunoassays for measurement of influenza A/Victoria/3/75 virus in nasal washes.
Lancet 1980;1(8173):851-3.
1980: Brian Murphy; L J Markoff; R M Chanock; S B Spring; H F Maassab; A P Kendal; N J Cox; Myron M Levine; R G Douglas; R F Betts; Robert B Couch; Thomas R Cate
Genetic approaches to attenuation of influenza A viruses for man.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1980;288(1029):401-15.
1980: J G Massicot; Brian Murphy; Francoise THIERRY; L Markoff; K Y Huang; R M Chanock
Temperature-sensitive mutants of influenza virus. Identification of the loci of the two ts lesions in the Udorn-ts-1A2 donor virus and the correlation of the presence of these two ts lesions with a predictable level of attenuation.
Virology 1980;101(1):242-9.
1980: Brian Murphy; F T Wood; J G Massicot; R M Chanock
Temperature-sensitive mutants of influenza A virus. Transfer of the two ts-1A2 ts lesions present in the Udorn/72-ts-1A2 donor virus to the influenza A/Alaska/6/77 (H3N2) wild type virus.
Archives of virology 1980;65(2):175-86.
1980: Brian Murphy; R M Chanock; R G Douglas; R F Betts; D H Waterman; H P Holley; D L Hoover; S Suwanagool; D R Nalin; Myron M Levine
Temperature-sensitive mutants of influenza A virus: evaluation of the Alaska/77-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.
Archives of virology 1980;65(2):169-73.
1980: Brian Murphy; M D Tolpin; J G Massicot; H Y Kim; R H Parrott; R M Chanock
Escape of a highly defective influenza A virus mutant from its temperature sensitive phenotype by extragenic suppression and other types of mutation.
Annals of the New York Academy of Sciences 1980;354():172-82.
1979: L J Markoff; Francoise THIERRY; Brian Murphy; R M Chanock
Relationship of genotype of recombinants of influenza A/Hong Kong/68-ts-1[E]virus used as live virus vaccines to virulence in humans.
Infection and immunity 1979;26(1):280-6.
1979: R G Douglas; L J Markoff; Brian Murphy; R M Chanock; R F Betts; F G Hayden; Myron M Levine; G A Van Blerk; S B Sotman; D R Nalin
Live Victoria/75-ts-1[E] influenza A virus vaccines in adult volunteers: role of hemagglutinin immunity in protection against illness and infection caused by influenza A virus.
Infection and immunity 1979;26(1):274-9.
1979: D D Richman; Brian Murphy
The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines.
Reviews of infectious diseases 1979;1(3):413-33.
1979: Brian Murphy; H P Holley; E J Berquist; Myron M Levine; S B Spring; H F Maassab; A P Kendal; R M Chanock
Cold-adapted variants of influenza A virus: evaluation in adult seronegative volunteers of A/Scotland/840/74 and A/Victoria/3/75 cold-adapted recombinants derived from the cold-adapted A/Ann Arbor/6/60 strain.
Infection and immunity 1979;23(2):253-9.
1979: Brian Murphy; R M Chanock; Myron M Levine; G A van Blerk; E J Berquist; R G Douglas; R F Betts; R B Couch; T R Cate
Temperature-sensitive mutants of influenza A virus: evaluation of the A/Victoria/75-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.
Infection and immunity 1979;23(2):249-52.
1979: L J Markoff; Brian Murphy; A J Kendal; R M Chanock
Probable association of plaque size with neuraminidase subtype among H3N2 influenza A viruses. Brief report.
Archives of virology 1979;62(3):277-80.
1979: R M Chanock; Brian Murphy
Genetic approaches to control of influenza.
Perspectives in biology and medicine 1979;22(2 Pt 2):S37-S48.
1979: Brian Murphy; R M Chanock
Present status of live influenza A virus vaccine.
Monographs in paediatrics 1979;11():1-20.
1979: R C Reichman; V G Pons; Brian Murphy; E A Caplan; R Dolin
Cell-mediated cytotoxicity following influenza infection and vaccination in humans.
Journal of medical virology 1979;4(1):1-14.
1978: Brian Murphy; F T Wood; J G Massicot; R M Chanock
Temperature-sensitive mutants of influenza virus. XVI. Transfer of the two ts lesions present in the Udorn/72-ts-1A2 donor virus to the Victoria/3/75 wild-type virus.
Virology 1978;88(2):244-51.
1978: Brian Murphy; F T Wood; J G Massicot; S B Spring; R M Chanock
Temperature-sensitive mutants of influenza virus. XV. The genetic and biological characterization of a recombinant influenza virus containing two ts lesions produced by mating two complementing, single lesion ts mutants.
Virology 1978;88(2):231-43.
1978: M B Grizzard; W T London; D L Sly; Brian Murphy; W D James; W P Parnell; R M Chanock
Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus.
Infection and immunity 1978;21(1):201-5.
1978: Brian Murphy; L J Markoff; N T Hosier; H M Rusten; R M Chanock; A P Kendal; R G Douglas; R F Betts; T R Cate; R B Couch; Myron M Levine; D H Waterman; H P Holley
Temperature-sensitive mutants of influenza A virus: evaluation of A/Victoria/3/75-ts-1[E] recombinant viruses in volunteers.
Infection and immunity 1978;20(3):671-7.
1978: Brian Murphy; N T Hosier; S B Spring; S R Mostow; R M Chanock
Temperature-sensitive mutants of influenza A virus: production and characterization of A/Victoria/3/75-ts-1[E] recombinants.
Infection and immunity 1978;20(3):665-70.
1978: R Dolin; Brian Murphy; E A Caplan
Lymphocyte blastogenic responses to influenza virus antigens after influenza infection and vaccination in humans.
Infection and immunity 1978;19(3):867-74.
1978: C Scholtissek; Brian Murphy
Host range mutants of an influenza A virus.
Archives of virology 1978;58(4):323-33.
1977: D D Richman; Brian Murphy; R M Chanock
Demonstration of a non-temperature-sensitive growth-restricting mutation in a ts mutant of influenza A virus: implications for live virus vaccine development.
Virology 1977;83(2):356-64.
1977: B C Easterday; Brian Murphy; S McGregor
Infection and vaccination of pigs with influenza A/New Jersey/8/76 (Hsw1N1) virus.
The Journal of infectious diseases 1977;136 Suppl():S699-702.
1977: J Massicot; Brian Murphy
Comparison of the hemagglutination-inhibiting and neutralizing antibody responses of volunteers given 400 chick cell-agglutinating units of influenza A/New Jersey/76 split-virus vaccine.
The Journal of infectious diseases 1977;136 Suppl():S472-4.
1977: A P Kendal; N J Cox; Brian Murphy; S B Spring; H F Maassab
Comparative studies of wild-type and 'cold-mutant' (temperature sensitive) influenza viruses: geneology of the matrix (M) and non-structural (NS) proteins in recombinant cold-adapted H3N2 viruses.
The Journal of general virology 1977;37(1):145-59.
1977: D D Richman; Brian Murphy; R B Belshe; H M Rusten; R M Chanock; N R Blacklow; Thomas Parrino; F B Rose; Myron M Levine; Ellis Caplan
Temperature-sensitive mutants of influenza A virus. XIV. Production and evaluation of influenza A/Georgia/74-ts-1[E] recombinant viruses in human adults.
The Journal of infectious diseases 1977;136(2):256-62.
1977: S R Mostow; S Flatauer; M Paler; Brian Murphy
Temperature-sensitive mutants of influenza virus. XIII. Evaluation of influenza A/Hong Kong/68 and A/Udorn/72 ts and wild-type viruses in tracheal organ culture at permissive and restrictive temperatures.
The Journal of infectious diseases 1977;136(1):1-6.
1977: Brian Murphy; L J Markoff; R M Chanock; R G Douglas; R F Betts; T R Cate; R B Couch
An evaluation of influenza A/Victoria/3/75-ts-1 [E] recombinant viruses for attenuation and immunogenicity in adult seronegative volunteers.
Developments in biological standardization 1977;39():47-52.
1977: H F Maassab; N J Cox; Brian Murphy; A P Kendal
Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers.
Developments in biological standardization 1977;39():25-31.
1977: R Dolin; D D Richman; Brian Murphy; Anthony Fauci
Cell-mediated immune responses in humans after induced infection with influenza A virus.
The Journal of infectious diseases 1977;135(5):714-9.
1977: S B Spring; H F Maassab; A P Kendal; Brian Murphy; R M Chanock
Cold-adapted variants of influenza virus A. I. Comparison of the genetic properties of ts mutants and five cold-adapted variants of influenza virus A.
Virology 1977;77(1):337-43.
1977: S B Spring; H F Maassab; A P Kendal; Brian Murphy; R M Chanock
Cold adapted variants of influenza A. II. Comparison of the genetic and biological properties of ts mutants and recombinants of the cold adapted A/AA/6/60 strain.
Archives of virology 1977;55(3):233-46.
1976: D D Richman; Brian Murphy; R M Chanock; J M Gwaltney; R G Douglas; R F Betts; N R Blacklow; F B Rose; Thomas Parrino; Myron M Levine; Ellis Caplan
Temperature-sensitive mutants of influenza A virus. XII. Safety, antigenicity, transmissibility, and efficacy of influenza A/Udorn/72-ts-1[E] recombinant viruses in human adults.
The Journal of infectious diseases 1976;134(6):585-94.
1976: Brian Murphy; E L Tierney; S B Spring; R M Chanock
Temperature-sensitive mutants of influenza A virus. XI. Transfer of ts lesions in the Hong Kong/68-ts-1 [a] virus to the influenza A/Udorn/72 wild type.
The Journal of infectious diseases 1976;134(6):577-84.
1976: Brian Murphy; D D Richman; S B Spring; R M Chanock
Use of temperature-sensitive mutants of influenza A virus as live virus vaccine strains. Evaluation in laboratory animals, adults and children.
Postgraduate medical journal 1976;52(608):381-8.
1976: H W Kim; J O Arrobio; C D Brandt; R H Parrott; Brian Murphy; D D Richman; R M Chanock
Temperature-sensitive mutants of influenza A virus: response of children to the influenza A/Hong Kong/68-ts-1(E) (H3N2) and influenza A/Udorn/72-ts-1(E) (H3N2) candidate vaccine viruses and significance of immunity to neuraminidase antigen.
Pediatric research 1976;10(4):238-42.
1976: D D Richman; Brian Murphy; S Baron; C Uhlendorf
Three strains of influenza A virus (H3N2): interferon sensitivity in vitro and interferon production in volunteers.
Journal of clinical microbiology 1976;3(3):223-6.
1976: R G Douglas; D W Bentley; R F Betts; D A Zaky; F K Roth; Brian Murphy
Evaluation of a temperature-sensitive influenza virus in elderly and chronically ill subjects.
The American review of respiratory disease 1976;113(3):293-300.
1976: W H Hall; R G Douglas; D A Zaky; R W Hyde; D Richman; Brian Murphy
Attenuated influenza virus in normal adults: role of pulmonary function studies in vaccine trials.
The Journal of infectious diseases 1976;133(2):145-52.
1975: Brian Murphy; S B Spring; D D Richman; E L Tierney; J Kasel; R M Chanock
Temperature-Sensitive mutants of influenza virus. VII. Transfer of the TS-1[E] lesions to a wild-type influenza A virus with the HON1 surface antigens.
Virology 1975;66(2):533-41.
1975: S B Spring; S R Nusinoff; J Mills; D D Richman; E L Tierney; Brian Murphy; R M Chanock
Temperature-sensitive mutants of influenza virus. VI. Transfer of TS lesions from the Asian subtype of influenza A virus (H2N2) to the Hong Kong subtype (H3N2).
Virology 1975;66(2):522-32.
1975: D D Richman; Brian Murphy; S B Spring; M T Coleman; R M Chanock
Temperature sensitive mutants of influenza virus. IX. Genetic and biological characterization of TS-1[E] lesions when transferred to a 1972 (H3N2) influenza A virus.
Virology 1975;66(2):551-62.
1975: S B Spring; S R Nusinoff; E L Tierney; D D Richman; Brian Murphy; R M Chanock
Temperature-sensitive mutants of influenza. VIII. Genetic and biological characterization of TS mutants of influenza virus A (H3N2) and their assignment to complementation groups.
Virology 1975;66(2):542-50.
1975: Brian Murphy; D D Richman; E G Chalhub; C P Uhlendorf; S Baron; R M Chanock
Failure of attenuated temperature-sensitive influenza A (H3N2) virus to induce heterologous interference in humans to parainfluenza type 1 virus.
Infection and immunity 1975;12(1):62-8.
1975: D D Richman; Brian Murphy; W L Cline; D W Alling
Determination of influenzavirus neuraminidase inhibition titres.
Bulletin of the World Health Organization 1975;52(2):233-4.
1974: D D Richman; Brian Murphy; E L Tierney; R M Chanock
Specificity of the local secretory antibody to influenza A virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1974;113(5):1654-6.
1974: Brian Murphy; D S Hodes; S R Nusinoff; S Spring-Stewart; E L Tierney; R M Chanock
Temperature-sensitive mutants of influenza virus. V. Evaluation in man of an additional ts recombinant virus with a 39 C shutoff temperature.
The Journal of infectious diseases 1974;130(2):144-9.
1973: Brian Murphy; S Baron; E G Chalhub; C P Uhlendorf; R M Chanock
Temperature-sensitive mutants of influenza virus. IV. Induction of interferon in the nasopharynx by wild-type and a temperature-sensitive recombinant virus.
The Journal of infectious diseases 1973;128(4):488-93.
1973: Brian Murphy; E G Chalhub; S R Nusinoff; J Kasel; R M Chanock
Temperature-sensitive mutants of influenza virus. 3. Further characterization of the ts-1(E) influenza A recombinant (H3N2) virus in man.
The Journal of infectious diseases 1973;128(4):479-87.
1973: R H Parrott; H W Kim; J O Arrobio; D S Hodes; Brian Murphy; C D Brandt; E Camargo; R M Chanock
Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex.
American journal of epidemiology 1973;98(4):289-300.
1972: Brian Murphy; E G Chalhub; S R Nusinoff; R M Chanock
Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man.
The Journal of infectious diseases 1972;126(2):170-8.
1972: Brian Murphy; J A Kasel; R M Chanock
Association of serum anti-neuraminidase antibody with resistance to influenza in man.
The New England journal of medicine 1972;286(25):1329-32.
1968: Brian Murphy; L A Glasgow
Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice.
The Journal of experimental medicine 1968;127(5):1035-52.
1967: Brian Murphy; L A Glasgow
Factors modifying host resistance to viral infection. I. Effect of immunosuppressive drugs on experimental infection of mice with encephalomyocarditis virus.
Antimicrobial agents and chemotherapy 1967;7():661-7.