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John O'Shea

Research Profile

Chemicals & Drugs

Physiology

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Mouse

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Phosphorylation

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Severe Combined Immunodeficiency

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Publications

TOP 3
Arian Dominic John laurence; Marko Pesu; Olli Silvennoinen; John O'Shea
JAK Kinases in Health and Disease: An Update.
Kamran Ghoreschi; Arian Dominic John laurence; Xiang-Ping Yang; Cristina M Tato; Mandy J McGeachy; Joanne E Konkel; Haydeé L Ramos; Lai Wei; Todd S Davidson; Nicolas Bouladoux; John R Grainger; Qian Chen; Yuka Kanno; Wendy T Watford; Hong-Wei Sun; Gérard Eberl; Ethan M Shevach; Yasmine Belkaid; Daniel J Cua; Wanjun Chen; John O'Shea
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
Stefan Kuchen; Wolfgang Resch; Arito Yamane; Nan Kuo; Zhiyu Li; Tirtha Chakraborty; Lai Wei; Arian Dominic John laurence; Tomoharu Yasuda; Siying Peng; Jane Hu-Li; Kristina Lu; Wendy Dubois; Yoshiaki Kitamura; Nicolas Charles; Hong-Wei Sun; Stefan Muljo; Pamela L Schwartzberg; William E Paul; John O'Shea; Klaus Rajewsky; Rafael Casellas
Regulation of microRNA expression and abundance during lymphopoiesis.

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All Publications

2012: Arian Dominic John laurence; Marko Pesu; Olli Silvennoinen; John O'Shea
JAK Kinases in Health and Disease: An Update.
The open rheumatology journal 2012;6():232-44.
2010: Kamran Ghoreschi; Arian Dominic John laurence; Xiang-Ping Yang; Cristina M Tato; Mandy J McGeachy; Joanne E Konkel; Haydeé L Ramos; Lai Wei; Todd S Davidson; Nicolas Bouladoux; John R Grainger; Qian Chen; Yuka Kanno; Wendy T Watford; Hong-Wei Sun; Gérard Eberl; Ethan M Shevach; Yasmine Belkaid; Daniel J Cua; Wanjun Chen; John O'Shea
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
Nature 2010;467(7318):967-71.
2010: Stefan Kuchen; Wolfgang Resch; Arito Yamane; Nan Kuo; Zhiyu Li; Tirtha Chakraborty; Lai Wei; Arian Dominic John laurence; Tomoharu Yasuda; Siying Peng; Jane Hu-Li; Kristina Lu; Wendy Dubois; Yoshiaki Kitamura; Nicolas Charles; Hong-Wei Sun; Stefan Muljo; Pamela L Schwartzberg; William E Paul; John O'Shea; Klaus Rajewsky; Rafael Casellas
Regulation of microRNA expression and abundance during lymphopoiesis.
Immunity 2010;32(6):828-39.
2010: Wendy T Watford; Chun-Chi Wang; Christos Tsatsanis; Lisa A Mielke; Aristides G Eliopoulos; Constantine Daskalakis; Nicolas Charles; Sandra Odom; Juan Rivera; John O'Shea; Philip Tsichlis
Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(1):105-13.
2009: Akiko Kimura; Michael A Rieger; James M Simone; Weiping Chen; Mark C Wickre; Bing-Mei Zhu; Philipp S Hoppe; John O'Shea; Timm Schroeder; Lothar Hennighausen
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood 2009;114(21):4721-8.
2009: Susannah D Brydges; James L Mueller; Matthew D McGeough; Carla A Pena; Amirhossein Misaghi; Chhavi Gandhi; Chris D Putnam; David L Boyle; Gary S Firestein; Anthony A Horner; pejman Soroosh; Wendy T Watford; John O'Shea; Daniel Kastner; Hal M Hoffman
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Immunity 2009;30(6):875-87.
2009: Nicolas Charles; Wendy T Watford; Haydeé L Ramos; Lars Hellman; Hans C Oettgen; Gregorio Gomez; John J Ryan; John O'Shea; Juan Rivera
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.
Immunity 2009;30(4):533-43.
2009: John O'Shea; Scott M Steward-Tharp; Arian Dominic John laurence; Wendy T Watford; Lai Wei; Adewole S Adamson; Samuel Fan
Signal transduction and Th17 cell differentiation.
Microbes and infection / Institut Pasteur 2009;11(5):599-611.
2009: Adewole S Adamson; Kalonji Collins; Arian Dominic John laurence; John O'Shea
The Current STATus of lymphocyte signaling: new roles for old players.
Current opinion in immunology 2009;21(2):161-6.
2009: Kamran Ghoreschi; Arian Dominic John laurence; John O'Shea
Selectivity and therapeutic inhibition of kinases: to be or not to be?
Nature immunology 2009;10(4):356-60.
2009: Kamran Ghoreschi; Arian Dominic John laurence; John O'Shea
Janus kinases in immune cell signaling.
Immunological reviews 2009;228(1):273-87.
2009: Mandy J McGeachy; Yi Chen; Cristina M Tato; Arian Dominic John laurence; Barbara Joyce-Shaikh; Wendy M Blumenschein; Terrill McClanahan; John O'Shea; Daniel J Cua
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
Nature immunology 2009;10(3):314-24.
2009: Gang Wei; Lai Wei; Jinfang Zhu; Chongzhi Zang; Jane Hu-Li; Zhengju Yao; Kairong Cui; Yuka Kanno; Tae-Young Roh; Wendy T Watford; Dustin E Schones; Weiqun Peng; Hong-Wei Sun; William Paul; John O'Shea; Keji Zhao
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.
Immunity 2009;30(1):155-67.
2009: Hiroaki Takatori; Yuka Kanno; Wendy T Watford; Cristina M Tato; Greta Weiss; Ivaylo I Ivanov; Dan R Littman; John O'Shea
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine 2009;206(1):35-41.
2008: Jian-kang Jiang; Kamran Ghoreschi; Francesca Deflorian; Zhi Chen; Melissa Perreira; Marko Pesu; Jeremy Smith; Dac-Trung Nguyen; Eric H Liu; William Leister; Stefano Costanzi; John O'Shea; Craig J Thomas
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
Journal of medicinal chemistry 2008;51(24):8012-8.
2008: Wendy T Watford; Bruce D Hissong; Lydia Durant; Hidehiro Yamane; Linda Muul; Yuka Kanno; Cristina M Tato; Haydeé L Ramos; Alan E Berger; Lisa Mielke; Marko Pesu; Benjamin Solomon; David M Frucht; William Paul; Alan Sher; Dragana Jankovic; Philip Tsichlis; John O'Shea
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
The Journal of experimental medicine 2008;205(12):2803-12.
2008: Marko Pesu; Wendy T Watford; Lai Wei; Lili Xu; Ivan J Fuss; Warren Strober; John Andersson; Ethan M Shevach; Martha Quezado; Nicolas Bouladoux; Anton Roebroek; Yasmine Belkaid; John Creemers; John O'Shea
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Nature 2008;455(7210):246-50.
2008: John Andersson; Dat Q Tran; Marko Pesu; Todd S Davidson; Heather Ramsey; John O'Shea; Ethan M Shevach
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
The Journal of experimental medicine 2008;205(9):1975-81.
2008: Lai Wei; Arian Dominic John laurence; John O'Shea
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation.
Seminars in cell & developmental biology 2008;19(4):394-400.
2008: V Cecchinato; C J Trindade; Arian Dominic John laurence; J M Heraud; J M Brenchley; M G Ferrari; L Zaffiri; E Tryniszewska; W P Tsai; M Vaccari; R Washington Parks; D Venzon; D C Douek; John O'Shea; G Franchini
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques.
Mucosal immunology 2008;1(4):279-88.
2008: Marko Pesu; Arian Dominic John laurence; Nandini Kishore; Samuel H Zwillich; Gary Chan; John O'Shea
Therapeutic targeting of Janus kinases.
Immunological reviews 2008;223():132-42.
2008: Roland Martin; John O'Shea; Linda S Birnbaum; Robert Luebke
Community corner. Striking the balance in multiple sclerosis.
Nature medicine 2008;14(5):491.
2008: John O'Shea; Christopher A Hunter; Ronald N Germain
T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
Nature immunology 2008;9(5):450-3.
2008: Joshua D Milner; Jason M Brenchley; Arian Dominic John laurence; Alexandra F Freeman; Brenna J Hill; Kevin M Elias; Yuka Kanno; Christine Spalding; Houda Z Elloumi; Michelle L Paulson; Joie Davis; Amy Hsu; Ava I Asher; John O'Shea; Steven M Holland; William Paul; Daniel C Douek
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Nature 2008;452(7188):773-6.
2008: John O'Shea; Peter J Murray
Cytokine signaling modules in inflammatory responses.
Immunity 2008;28(4):477-87.
2008: Arian Dominic John laurence; John O'Shea; Wendy T Watford
Interleukin-22: a sheep in wolf's clothing.
Nature medicine 2008;14(3):247-9.
2008: Zhi Chen; John O'Shea
Regulation of IL-17 production in human lymphocytes.
Cytokine 2008;41(2):71-8.
2008: Kevin M Elias; Arian Dominic John laurence; Todd S Davidson; Geoffrey Stephens; Yuka Kanno; Ethan M Shevach; John O'Shea
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
Blood 2008;111(3):1013-20.
2008: Kathryn E Foulds; Masashi J Rotte; Michael A Paley; Babu Singh; Daniel C Douek; Brenna J Hill; John O'Shea; Wendy T Watford; Robert A Seder; Chang-You Wu
IFN-gamma mediates the death of Th1 cells in a paracrine manner.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):842-9.
2008: Hiroaki Takatori; Yuka Kanno; Zhi Chen; John O'Shea
New complexities in helper T cell fate determination and the implications for autoimmune diseases.
Modern rheumatology / the Japan Rheumatism Association 2008;18(6):533-41.
2008: Zhi Chen; John O'Shea
Th17 cells: a new fate for differentiating helper T cells.
Immunologic research 2008;41(2):87-102.
2007: Zhi Chen; Arian Dominic John laurence; John O'Shea
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation.
Seminars in immunology 2007;19(6):400-8.
2007: Jason S Stumhofer; Jonathan S Silver; Arian Dominic John laurence; Paige M Porrett; Tajie Harris; Laurence A Turka; Matthias Ernst; Christiaan J M Saris; John O'Shea; Christopher A Hunter
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
Nature immunology 2007;8(12):1363-71.
2007: Lai Wei; Arian Dominic John laurence; Kevin M Elias; John O'Shea
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
The Journal of biological chemistry 2007;282(48):34605-10.
2007: Zhi Chen; Cristina M Tato; Linda Muul; Arian Dominic John laurence; John O'Shea
Distinct regulation of interleukin-17 in human T helper lymphocytes.
Arthritis and rheumatism 2007;56(9):2936-46.
2007: Arian Dominic John laurence; John O'Shea
T(H)-17 differentiation: of mice and men.
Nature immunology 2007;8(9):903-5.
2007: Heiyoung Park; Kabir Teja; John O'Shea; Richard Siegel
The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6426-34.
2007: Haydeé L Ramos; John O'Shea; Wendy T Watford
STAT5 isoforms: controversies and clarifications.
The Biochemical journal 2007;404(1):e1-2.
2007: Zhengju Yao; Yuka Kanno; Marc Kerenyi; Geoffrey Stephens; Lydia Durant; Wendy T Watford; Arian Dominic John laurence; Gertraud W Robinson; Ethan M Shevach; Richard Moriggl; Lothar Hennighausen; Changyou Wu; John O'Shea
Nonredundant roles for Stat5a/b in directly regulating Foxp3.
Blood 2007;109(10):4368-75.
2007: Hongjie Li; Wendy Watford; Cuiling Li; Alissa Parmelee; Mark A Bryant; Chuxia Deng; John O'Shea; Sean Bong Lee
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.
The Journal of clinical investigation 2007;117(5):1314-23.
2007: Arian Dominic John laurence; Cristina M Tato; Todd S Davidson; Yuka Kanno; Zhi Chen; Zhengju Yao; Rebecca B Blank; Françoise Meylan; Richard Siegel; Lothar Hennighausen; Ethan M Shevach; John O'Shea
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Immunity 2007;26(3):371-81.
2007: Alejandro V Villarino; Cristina M Tato; Jason S Stumhofer; Zhengju Yao; Yongzhi K Cui; Lothar Hennighausen; John O'Shea; Christopher A Hunter
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
The Journal of experimental medicine 2007;204(1):65-71.
2007: Eric H Liu; Richard Siegel; David M Harlan; John O'Shea
T cell-directed therapies: lessons learned and future prospects.
Nature immunology 2007;8(1):25-30.
2006: Wendy T Watford; John O'Shea
Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.
Immunity 2006;25(5):695-7.
2006: Wendy T Watford; Denise Li; Davide Agnello; Lydia Durant; Kunihiro Yamaoka; Zheng Ju Yao; Hyun-Jong Ahn; Tammy P Cheng; Sigrun Hofmann; Tiziana Cogliati; Amy Chen; Bruce D Hissong; Matthew R Husa; Pamela Schwartzberg; John O'Shea; Massimo Gadina
Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.
Molecular and cellular biology 2006;26(17):6623-32.
2006: Jason S Stumhofer; Arian Dominic John laurence; Emma H Wilson; Elaine Huang; Cristina M Tato; Leanne M Johnson; Alejandro V Villarino; Qiulong Huang; Akihiko Yoshimura; David Sehy; Christiaan J M Saris; John O'Shea; Lothar Hennighausen; Matthias Ernst; Christopher A Hunter
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Nature immunology 2006;7(9):937-45.
2006: Marko Pesu; Linda Muul; Yuka Kanno; John O'Shea
Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.
Blood 2006;108(3):983-5.
2006: Zhi Chen; Arian Dominic John laurence; Yuka Kanno; Margit Pacher-Zavisin; Bing-Mei Zhu; Cristina M Tato; Akihiko Yoshimura; Lothar Hennighausen; John O'Shea
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8137-42.
2006: Cristina M Tato; John O'Shea
Immunology: what does it mean to be just 17?
Nature 2006;441(7090):166-8.
2006: Cristina M Tato; Arian Dominic John laurence; John O'Shea
Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
The Journal of experimental medicine 2006;203(4):809-12.
2006: Takashi Usui; Jan C Preiss; Yuka Kanno; Zheng Ju Yao; Jay H Bream; John O'Shea; Warren Strober
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.
The Journal of experimental medicine 2006;203(3):755-66.
2006: Zhengju Yao; Yongzhi Cui; Wendy T Watford; Jay H Bream; Kunihiro Yamaoka; Bruce D Hissong; Denise Li; Scott K Durum; Qiong Jiang; Avinash Bhandoola; Lothar Hennighausen; John O'Shea
Stat5a/b are essential for normal lymphoid development and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1000-5.
2005: Kunihiro Yamaoka; Booki Min; Yong-Jie Zhou; William Paul; John O'Shea
Jak3 negatively regulates dendritic-cell cytokine production and survival.
Blood 2005;106(9):3227-33.
2005: Marko Pesu; John O'Shea; Lothar Hennighausen; Olli Silvennoinen
Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders.
Molecular interventions 2005;5(4):211-5.
2005: John O'Shea; Heiyoung Park; Marko Pesu; Dominic C Borie; Paul Changelian
New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.
Current opinion in rheumatology 2005;17(3):305-11.
2005: Masato Moriguchi; Bruce D Hissong; Massimo Gadina; Kunihiro Yamaoka; H Lee Tiffany; Philip M Murphy; Fabio Candotti; John O'Shea
CXCL12 signaling is independent of Jak2 and Jak3.
The Journal of biological chemistry 2005;280(17):17408-14.
2005: Tomohiko Tamura; Prafullakumar Tailor; Kunihiro Yamaoka; Hee Jeong Kong; Hideki Tsujimura; John O'Shea; Harinder Singh; Keiko Ozato
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2573-81.
2005: Marko Pesu; Fabio Candotti; Matthew Husa; Sigrun Hofmann; Luigi D Notarangelo; John O'Shea
Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.
Immunological reviews 2005;203():127-42.
2005: John O'Shea; Yuka Kanno; Xiaomin Chen; David E Levy
Cell signaling. Stat acetylation--a key facet of cytokine signaling?
Science (New York, N.Y.) 2005;307(5707):217-8.
2004: Wendy T Watford; Bruce D Hissong; Jay H Bream; Yuka Kanno; Linda Muul; John O'Shea
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Immunological reviews 2004;202():139-56.
2004: Dominic C Borie; John O'Shea; Paul Changelian
JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants.
Trends in molecular medicine 2004;10(11):532-41.
2004: John O'Shea
Targeting the Jak/STAT pathway for immunosuppression.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii67-ii71.
2004: Akio Morinobu; Yuka Kanno; John O'Shea
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression.
The Journal of biological chemistry 2004;279(39):40640-6.
2004: Jay H Bream; Deborah L Hodge; Rivkah Gonsky; Rosanne Spolski; Warren J Leonard; Stephanie Krebs; Stephan R Targan; Akio Morinobu; John O'Shea; Howard A Young
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
The Journal of biological chemistry 2004;279(39):41249-57.
2004: John O'Shea; Wendy Watford
A peek at PIAS.
Nature immunology 2004;5(9):875-6.
2004: John O'Shea; Marko Pesu; Dominic C Borie; Paul Changelian
A new modality for immunosuppression: targeting the JAK/STAT pathway.
Nature reviews. Drug discovery 2004;3(7):555-64.
2004: John O'Shea; Matthew Husa; Denise Li; Sigrun Hofmann; Wendy T Watford; Joseph L Roberts; Rebecca H Buckley; Paul Changelian; Fabio Candotti
Jak3 and the pathogenesis of severe combined immunodeficiency.
Molecular immunology 2004;41(6-7):727-37.
2004: Sigrun Hofmann; Albert Q Lam; Stephan Frank; Yong-Jie Zhou; Haydeé L Ramos; Yuka Kanno; Davide Agnello; Richard J Youle; John O'Shea
Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.
Molecular and cellular biology 2004;24(11):5039-49.
2004: Zhengqi Wu; Margaret Roberts; Melissa Porter; Fabianne Walker; E John Wherry; John Kelly; Massimo Gadina; Elisabeth M Silva; George A DosReis; Marcela F Lopes; John O'Shea; Warren J Leonard; Rafi Ahmed; Richard Siegel
Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6313-23.
2004: Jason H Kurzer; Lawrence S Argetsinger; Yong-Jie Zhou; Jean-Louis K Kouadio; John O'Shea; Christin Carter-Su
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Molecular and cellular biology 2004;24(10):4557-70.
2004: Joseph L Roberts; Andrea J Lengi; Stephanie M Brown; Min Chen; Yong-Jie Zhou; John O'Shea; Rebecca H Buckley
Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.
Blood 2004;103(6):2009-18.
2004: Kunihiro Yamaoka; Pipsa Saharinen; Marko Pesu; Vance E T Holt; Olli Silvennoinen; John O'Shea
The Janus kinases (Jaks).
Genome biology 2004;5(12):253.
2003: Paul Changelian; Mark E Flanagan; Douglas J Ball; Craig R Kent; Kelly S Magnuson; William Martin; Bonnie J Rizzuti; Perry S Sawyer; Bret Daren Perry; William H Brissette; Sandra P McCurdy; Elizabeth M Kudlacz; Maryrose J Conklyn; Eileen A Elliott; Erika R Koslov; Michael B Fisher; Timothy J Strelevitz; Kwansik Yoon; David A Whipple; Jianmin Sun; Michael J Munchhof; John L Doty; Jeffrey M Casavant; Todd A Blumenkopf; Michael Hines; Matthew F Brown; Brett M Lillie; Chakrapani Subramanyam; Chang Shang-Poa; Anthony J Milici; Gretchen E Beckius; James D Moyer; Chunyan Su; Thasia G Woodworth; Anderson S Gaweco; Chan R Beals; Bruce H Littman; Douglas A Fisher; James F Smith; Panayiotis Zagouras; Holly A Magna; Mary Saltarelli; Kimberly S Johnson; Linda F Nelms; Shelley G Des Etages; Lisa S Hayes; Thomas T Kawabata; Deborah Finco-Kent; Deanna L Baker; Michael Larson; Ming-Sing Si; Ricardo Paniagua; John Higgins; Bari Holm Nazario; Bruce Reitz; Yong-Jie Zhou; randall morris; John O'Shea; Dominic C Borie
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Science (New York, N.Y.) 2003;302(5646):875-8.
2003: Wendy T Watford; Masato Moriguchi; Akio Morinobu; John O'Shea
The biology of IL-12: coordinating innate and adaptive immune responses.
Cytokine & growth factor reviews 2003;14(5):361-8.
2003: Jean-Louis Boulay; John O'Shea; William Paul
Molecular phylogeny within type I cytokines and their cognate receptors.
Immunity 2003;19(2):159-63.
2003: John O'Shea; Steven Holland; Fabio Candotti
Primary immunodeficiencies and the rheumatologist.
Current opinion in rheumatology 2003;15(4):413-6.
2003: Martin Aringer; Sigrun Hofmann; David M Frucht; Min Chen; Michael Centola; Akio Morinobu; Roberta Visconti; Daniel Kastner; Josef S Smolen; John O'Shea
Characterization and analysis of the proximal Janus kinase 3 promoter.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6057-64.
2003: James A Johnston; John O'Shea
Matching SOCS with function.
Nature immunology 2003;4(6):507-9.
2003: Davide Agnello; Carla S R Lankford; Jay H Bream; Akio Morinobu; Massimo Gadina; John O'Shea; David M Frucht
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.
Journal of clinical immunology 2003;23(3):147-61.
2003: John O'Shea; K Donald Shelbourne
Repair of locked bucket-handle meniscal tears in knees with chronic anterior cruciate ligament deficiency.
The American journal of sports medicine 2003;31(2):216-20.
2003: Wendy T Watford; John O'Shea
Autoimmunity: A case of mistaken identity.
Nature 2003;421(6924):706-8.
2003: Joseph T Moskal; John O'Shea
Intramedullary stabilization of distal-third femur fractures in octogenarians.
Journal of the Southern Orthopaedic Association 2003;12(1):3-8.
2002: Sigrun Hofmann; Catherine Rachel Ettinger; Yong-Jie Zhou; Massimo Gadina; Peter E Lipsky; Richard Siegel; Fabio Candotti; John O'Shea
Cytokines and their role in lymphoid development, differentiation and homeostasis.
Current opinion in allergy and clinical immunology 2002;2(6):495-506.
2002: Ivona Aksentijevich; Miroslawa Nowak; Mustapha Mallah; Jae Jin Chae; Wendy T Watford; Sigrun Hofmann; Leonard Stein; Ricardo Russo; Donald Goldsmith; Peter Dent; Helene F Rosenberg; Frances Austin; Elaine F Remmers; James E Balow; Sergio Rosenzweig; Hirsh Komarow; Nitza G Shoham; Geryl Wood; Janet Jones; Nadira Mangra; Hector Carrero; Barbara S Adams; Terry L Moore; Kenneth Schikler; Hal Hoffman; Daniel J Lovell; Robert Lipnick; Karyl Barron; John O'Shea; Daniel Kastner; Raphaela Goldbach-Mansky
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
Arthritis and rheumatism 2002;46(12):3340-8.
2002: Ryuta Nishikomori; Takashi Usui; Chang-Yu Wu; Akio Morinobu; John O'Shea; Warren Strober
Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4388-98.
2002: Khuong B Nguyen; Wendy T Watford; Rachelle Salomon; Sigrun Hofmann; Gary C Pien; Akio Morinobu; Massimo Gadina; John O'Shea; Christine A Biron
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
Science (New York, N.Y.) 2002;297(5589):2063-6.
2002: Akio Morinobu; Massimo Gadina; Warren Strober; Roberta Visconti; Albert J Fornace; Cristina Montagna; Gerald M Feldman; Ryuta Nishikomori; John O'Shea
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12281-6.
2002: Valentino Parravicini; Massimo Gadina; Martina Kovarova; Sandra Odom; Claudia Gonzalez-Espinosa; Yasuko Furumoto; Shinichiroh Saitoh; Lawrence E Samelson; John O'Shea; Juan Rivera
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Nature immunology 2002;3(8):741-8.
2002: John O'Shea; William Paul
Regulation of T(H)1 differentiation--controlling the controllers.
Nature immunology 2002;3(6):506-8.
2002: Fabio Candotti; Luigi D Notarangelo; Roberta Visconti; John O'Shea
Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.
The Journal of clinical investigation 2002;109(10):1261-9.
2002: John O'Shea; Massimo Gadina; Robert D Schreiber
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
Cell 2002;109 Suppl():S121-31.
2002: Karen B O'Brien; John O'Shea; Christin Carter-Su
SH2-B family members differentially regulate JAK family tyrosine kinases.
The Journal of biological chemistry 2002;277(10):8673-81.
2002: Pingtao Tang; Tammy P Cheng; Davide Agnello; Chang-You Wu; Bruce D Hissong; Wendy T Watford; Hyun-Jong Ahn; Jérôme Galon; Joel Moss; Martha Vaughan; John O'Shea; Massimo Gadina
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2625-9.
2002: John O'Shea; K Donald Shelbourne
Anterior cruciate ligament reconstruction with a reharvested bone-patellar tendon-bone graft.
The American journal of sports medicine 2002;30(2):208-13.
2002: Denis Franchimont; Jérôme Galon; Melanie S Vacchio; Samuel Fan; Roberta Visconti; David M Frucht; Vincent Geenen; George Chrousos; Jonathan D Ashwell; John O'Shea
Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2212-8.
2002: Paul R Mittelstadt; Jérôme Galon; Denis Franchimont; John O'Shea; Jonathan D Ashwell
Glucocorticoid-inducible genes that regulate T-cell function.
Ernst Schering Research Foundation workshop 2002;(40):319-39.
2002: K Donald Shelbourne; John O'Shea
Revision anterior cruciate ligament reconstruction using the contralateral bone-patellar tendon-bone graft.
Instructional course lectures 2002;51():343-6.
2002: John O'Shea; Averil Ma; Peter E Lipsky
Cytokines and autoimmunity.
Nature reviews. Immunology 2002;2(1):37-45.
2002: Jérôme Galon; Denis Franchimont; Naoki Hiroi; Gregory Frey; Antje Boettner; Monika Ehrhart-Bornstein; John O'Shea; George Chrousos; Stefan R Bornstein
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):61-71.
2001: A A Lighvani; David M Frucht; Dragana Jankovic; H Yamane; Julio Aliberti; Bruce D Hissong; B V Nguyen; Massimo Gadina; A Sher; William Paul; John O'Shea
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15137-42.
2001: David M Frucht; Massimo Gadina; G Jayashree Jagadeesh; Ivona Aksentijevich; K Takada; Jack J H Bleesing; J Nelson; Linda Muul; G Perham; G Morgan; E J Gerritsen; R Fabian Schumacher; Patrizia Mella; P A Veys; Thomas A Fleisher; E R Kaminski; Luigi D Notarangelo; John O'Shea; Fabio Candotti
Unexpected and variable phenotypes in a family with JAK3 deficiency.
Genes and immunity 2001;2(8):422-32.
2001: John O'Shea; JA Johnston; J Kehrl; G Koretzky; L E Samelson
Key molecules involved in receptor-mediated lymphocyte activation.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 11():Unit 11.9A.
2001: Yong-Jie Zhou; Min Chen; N A Cusack; L H Kimmel; KS Magnuson; J G Boyd; W Lin; Joseph L Roberts; Andrea J Lengi; Rebecca H Buckley; R L Geahlen; Fabio Candotti; Massimo Gadina; Paul Changelian; John O'Shea
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
Molecular cell 2001;8(5):959-69.
2001: Daniel Kastner; John O'Shea
A fever gene comes in from the cold.
Nature genetics 2001;29(3):241-2.
2001: David M Frucht; Taro Fukao; C Bogdan; H Schindler; John O'Shea; Shigeo Koyasu
IFN-gamma production by antigen-presenting cells: mechanisms emerge.
Trends in immunology 2001;22(10):556-60.
2001: Ivona Aksentijevich; Jérôme Galon; M Soares; Elizabeth Mansfield; Keith M Hull; H H Oh; Raphaela Goldbach-Mansky; Jurrien Dean; B Athreya; A J Reginato; M Henrickson; Bernardo A Pons-Estel; John O'Shea; Daniel Kastner
The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.
American journal of human genetics 2001;69(2):301-14.
2001: K Tomita; Saijo Keiichi; Sho Yamasaki; T Iida; Fubito Nakatsu; Hisashi Arase; Hiroshi Ohno; Takuji Shirasawa; Takayuki Kuriyama; John O'Shea; Takashi Saito
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex.
The Journal of biological chemistry 2001;276(27):25378-85.
2001: Massimo Gadina; D Hilton; J A Johnston; Akio Morinobu; A Lighvani; Yong-Jie Zhou; Roberta Visconti; John O'Shea
Signaling by type I and II cytokine receptors: ten years after.
Current opinion in immunology 2001;13(3):363-73.
2001: Taro Fukao; David M Frucht; G Yap; Massimo Gadina; John O'Shea; Shigeo Koyasu
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4446-55.
2001: N L Monson; T J Fenske; S Wei; AJ Okragly; JL de Jong; Mary Haak-Frendscho; John O'Shea; J Djeu; Paul M Sondel
A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2.
Journal of leukocyte biology 2001;69(3):419-25.
2000: C Wu; X Wang; M Gadina; John O'Shea; DH Presky; Jeanne Magram
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6221-8.
2000: John O'Shea; Roberta Visconti; Tammy P Cheng; Massimo Gadina
Jaks and stats as therapeutic targets.
Annals of the rheumatic diseases 2000;59 Suppl 1():i115-8.
2000: Roberta Visconti; Massimo Gadina; M Chiariello; E H Chen; L F Stancato; J Silvio Gutkind; John O'Shea
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Blood 2000;96(5):1844-52.
2000: Massimo Gadina; C Sudarshan; Roberta Visconti; Yong-Jie Zhou; H Gu; B G Neel; John O'Shea
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
The Journal of biological chemistry 2000;275(35):26959-66.
2000: Mauno Vihinen; Anna Villa; Patrizia Mella; R Fabian Schumacher; Gianfranco Savoldi; John O'Shea; Fabio Candotti; Luigi D Notarangelo
Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency.
Clinical immunology (Orlando, Fla.) 2000;96(2):108-18.
2000: Jérôme Galon; Ivona Aksentijevich; Michael F McDermott; John O'Shea; Daniel Kastner
TNFRSF1A mutations and autoinflammatory syndromes.
Current opinion in immunology 2000;12(4):479-86.
2000: K Endo; T Takeshita; H Kasai; Y Sasaki; Nobuyuki Tanaka; Hironobu Asao; K Kikuchi; M Yamada; M Chenb; John O'Shea; Kazuo Sugamura
STAM2, a new member of the STAM family, binding to the Janus kinases.
FEBS letters 2000;477(1-2):55-61.
2000: John O'Shea; R Visconti
Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge.
Nature immunology 2000;1(1):17-9.
2000: Yong-Jie Zhou; KS Magnuson; Tammy P Cheng; Massimo Gadina; David M Frucht; Jérôme Galon; Fabio Candotti; R L Geahlen; Paul Changelian; John O'Shea
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
Molecular and cellular biology 2000;20(12):4371-80.
2000: Michael Centola; Geryl Wood; David M Frucht; Jérôme Galon; Martin Aringer; C Farrell; Douglas W Kingma; Mitchell E Horwitz; Elizabeth Mansfield; Steven M Holland; John O'Shea; H F Rosenberg; Harry L Malech; Daniel Kastner
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
Blood 2000;95(10):3223-31.
2000: Chang-You Wu; Massimo Gadina; K Wang; John O'Shea; Robert A Seder
Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells.
European journal of immunology 2000;30(5):1364-74.
2000: David M Frucht; Martin Aringer; Jérôme Galon; Carol L Danning; M Brown; S Fan; Michael Centola; C Y Wu; N Yamada; Hani El-Gabalawy; John O'Shea
Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4659-64.
2000: Denis Franchimont; Jérôme Galon; Massimo Gadina; Roberta Visconti; Y Zhou; Martin Aringer; David M Frucht; George Chrousos; John O'Shea
Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1768-74.
2000: Makoto Otsu; Stacie M Anderson; David M Bodine; Jennifer M Puck; John O'Shea; Fabio Candotti
Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):145-53.
2000: Min Chen; A Cheng; Fabio Candotti; Yong-Jie Zhou; A Hymel; A Fasth; Luigi D Notarangelo; John O'Shea
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.
Molecular and cellular biology 2000;20(3):947-56.
2000: C Contursi; I Ming Wang; Lucia Gabriele; Massimo Gadina; John O'Shea; Herbert C Morse; Keiko Ozato
IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):91-6.
2000: R A Ortmann; T Cheng; Roberta Visconti; David M Frucht; John O'Shea
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.
Arthritis research 2000;2(1):16-32.
2000: R Fabian Schumacher; Patrizia Mella; Raffaele Badolato; Maurilia Fiorini; Gianfranco Savoldi; Silvia Giliani; Anna Villa; Fabio Candotti; A Tampalini; John O'Shea; Luigi D Notarangelo
Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism.
Human genetics 2000;106(1):73-9.
2000: John O'Shea
Something happens; a brief history of TCR signal transduction.
Methods in molecular biology (Clifton, N.J.) 2000;134():197-207.
1999: Jérôme Galon; C Sudarshan; S Ito; D Finbloom; John O'Shea
IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7256-62.
1999: E Chen; Massimo Gadina; M Chen; John O'Shea
Advances in cytokine signaling: the role of Jaks and STATs.
Transplantation proceedings 1999;31(3):1482-7.
1999: M F McDermott; I Aksentijevich; J Galon; E M McDermott; B W Ogunkolade; M Centola; E Mansfield; M Gadina; L Karenko; T Pettersson; J McCarthy; D M Frucht; M Aringer; YELIZAVETA TOROSYAN; A M Teppo; M Wilson; H M Karaarslan; Y Wan; I Todd; G Wood; R Schlimgen; T R Kumarajeewa; S M Cooper; J P Vella; C I Amos; J Mulley; K A Quane; M G Molloy; A Ranki; R J Powell; G A Hitman; John O'Shea; Daniel Kastner
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.
Cell 1999;97(1):133-44.
1999: Vladimir Kolenko; Patricia Rayman; B Roy; Martha K Cathcart; John O'Shea; Raymond Tubbs; Lisa Rybicki; Ronald Bukowski; James Finke
Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway.
Blood 1999;93(7):2308-18.
1999: NA Cacalano; TS Migone; J. Fernando Bazan; E P Hanson; M Chen; F Candotti; John O'Shea; JA Johnston
Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
The EMBO journal 1999;18(6):1549-58.
1999: C Sudarshan; Jérôme Galon; Y Zhou; John O'Shea
TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2974-81.
1999: Massimo Gadina; C Sudarshan; John O'Shea
IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2081-6.
1999: Martin Aringer; A Cheng; J W Nelson; M Chen; C Sudarshan; Yong-Jie Zhou; John O'Shea
Janus kinases and their role in growth and disease.
Life sciences 1999;64(24):2173-86.
1998: Thomas Waldmann; John O'Shea
The use of antibodies against the IL-2 receptor in transplantation.
Current opinion in immunology 1998;10(5):507-12.
1998: F Bozzi; Gérard Lefranc; Anna Villa; Raffaele Badolato; R Fabian Schumacher; G Khalil; Jacques Loiselet; S Bresciani; John O'Shea; Paolo Vezzoni; Luigi D Notarangelo; Fabio Candotti
Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment.
British journal of haematology 1998;102(5):1363-6.
1998: E H Chen; Massimo Gadina; Jérôme Galon; M Chen; John O'Shea
Not just another meeting: the coming of age of JAKs and STATs.
Immunology today 1998;19(8):338-41.
1998: Massimo Gadina; L M Stancato; C M Bacon; A C Larner; John O'Shea
Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4657-61.
1998: Fabio Candotti; John O'Shea; A Villa
Severe combined immune deficiencies due to defects of the common gamma chain-JAK3 signaling pathway.
Springer seminars in immunopathology 1998;19(4):401-15.
1998: Warren J Leonard; John O'Shea
Jaks and STATs: biological implications.
Annual review of immunology 1998;16():293-322.
1997: Yong-Jie Zhou; E P Hanson; Y Q Chen; KS Magnuson; Min Chen; P G Swann; R L Wange; Paul Changelian; John O'Shea
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13850-5.
1997: Fabio Candotti; S A Oakes; J A Johnston; Silvia Giliani; R Fabian Schumacher; Patrizia Mella; Maurilia Fiorini; Alberto G Ugazio; Raffaele Badolato; Luigi D Notarangelo; F Bozzi; P Macchi; D Strina; Paolo Vezzoni; R. Michael Blaese; John O'Shea; Anna Villa
Structural and functional basis for JAK3-deficient severe combined immunodeficiency.
Blood 1997;90(10):3996-4003.
1997: John O'Shea; Luigi D Notarangelo; J A Johnston; Fabio Candotti
Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.
Journal of clinical immunology 1997;17(6):431-47.
1997: Vladimir Kolenko; Q Wang; M C Riedy; John O'Shea; Jerome Ritz; Martha K Cathcart; Patricia Rayman; Raymond Tubbs; MG Edinger; Andrew C Novick; Ronald Bukowski; James Finke
Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):3057-67.
1997: John O'Shea
Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?
Immunity 1997;7(1):1-11.
1997: Min Chen; A Cheng; Y Q Chen; A Hymel; E P Hanson; L Kimmel; Y Minami; T Taniguchi; Paul Changelian; John O'Shea
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6910-5.
1997: Nigel Sharfe; Harjit Dadi; John O'Shea; Chaim M Roifman
Jak3 activation in human lymphocyte precursor cells.
Clinical and experimental immunology 1997;108(3):552-6.
1997: N Taylor; Fabio Candotti; S Smith; S A Oakes; Thomas Jahn; J Isakov; J M Puck; John O'Shea; Kenneth I Weinberg; J A Johnston
Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.
The Journal of biological chemistry 1997;272(11):7314-9.
1996: S A Oakes; Fabio Candotti; JA Johnston; Y Q Chen; John J Ryan; N Taylor; Xibao Liu; Lothar Hennighausen; Luigi D Notarangelo; William Paul; R. Michael Blaese; John O'Shea
Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.
Immunity 1996;5(6):605-15.
1996: S S Cho; C M Bacon; C Sudarshan; R C Rees; D Finbloom; R Pine; John O'Shea
Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):4781-9.
1996: C M Bacon; S S Cho; John O'Shea
Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast.
Annals of the New York Academy of Sciences 1996;795():41-59.
1996: M C Riedy; A S Dutra; T B Blake; W Modi; Brajesh Lal; J Davis; A Bosse; John O'Shea; JA Johnston
Genomic sequence, organization, and chromosomal localization of human JAK3.
Genomics 1996;37(1):57-61.
1996: JA Johnston; C M Bacon; M C Riedy; John O'Shea
Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency.
Journal of leukocyte biology 1996;60(4):441-52.
1996: Fabio Candotti; S A Oakes; JA Johnston; Luigi D Notarangelo; John O'Shea; R. Michael Blaese
In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.
The Journal of experimental medicine 1996;183(6):2687-92.
1996: Daniel W McVicar; T B Blake; C M Burns; K C Conlon; John R Ortaldo; John O'Shea
Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells: a biochemical correlate of lymphoid functional activity.
Cellular immunology 1996;169(2):302-8.
1996: Fabio Candotti; JA Johnston; Jennifer M Puck; K Sugamura; John O'Shea; R. Michael Blaese
Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.
Blood 1996;87(8):3097-102.
1995: P J Tortolani; Brajesh Lal; A Riva; JA Johnston; Y Q Chen; G H Reaman; M Beckwith; Dan Longo; John R Ortaldo; K Bhatia; I McGrath; J Kehrl; Joseph M Tuscano; Daniel W McVicar; John O'Shea
Regulation of JAK3 expression and activation in human B cells and B cell malignancies.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5220-6.
1995: GA Evans; M A Goldsmith; JA Johnston; W Xu; S R Weiler; RA Erwin; O M Zack Howard; R T Abraham; John O'Shea; Warner Greene
Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association.
The Journal of biological chemistry 1995;270(48):28858-63.
1995: JA Johnston; L M Wang; E P Hanson; Xiao Jian Sun; M F White; S A Oakes; J H Pierce; John O'Shea
Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
The Journal of biological chemistry 1995;270(48):28527-30.
1995: S M Russell; N Tayebi; Hiroshi Nakajima; M C Riedy; J L Roberts; M J Aman; TS Migone; M Noguchi; M L Markert; R H Buckley; John O'Shea; Warren J Leonard
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
Science (New York, N.Y.) 1995;270(5237):797-800.
1995: Arnold H Zea; B D Curti; Dan Longo; W Gregory Alvord; S L Strobl; H Mizoguchi; Stephen Creekmore; John O'Shea; G C Powers; W J Urba
Alterations in T cell receptor and signal transduction molecules in melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1327-35.
1995: Robert A Kirken; Hallgeir Rui; Maria Grazia Malabarba; O M Zack Howard; M Kawamura; John O'Shea; William L Farrar
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
Cytokine 1995;7(7):689-700.
1995: P Macchi; A Villa; Silvia Giliani; Maria Grazia Sacco; Annalisa Frattini; F Porta; Alberto G Ugazio; JA Johnston; Fabio Candotti; John O'Shea
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).
Nature 1995;377(6544):65-8.
1995: X Xu; S H Kang; Olaf Heidenreich; M Okerholm; John O'Shea; M I Nerenberg
Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.
The Journal of clinical investigation 1995;96(3):1548-55.
1995: Achsah D Keegan; JA Johnston; P J Tortolani; L J McReynolds; C Kinzer; John O'Shea; William Paul
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7681-5.
1995: C M Bacon; P J Tortolani; A Shimosaka; R C Rees; Dan Longo; John O'Shea
Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3.
FEBS letters 1995;370(1-2):63-8.
1995: C M Bacon; Emanuel F Petricoin; John R Ortaldo; R C Rees; Andrew C Larner; JA Johnston; John O'Shea
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7307-11.
1995: TS Migone; J X Lin; A Cereseto; JC Mulloy; John O'Shea; Genoveffa Franchini; Warren J Leonard
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
Science (New York, N.Y.) 1995;269(5220):79-81.
1995: P J Tortolani; JA Johnston; C M Bacon; Daniel W McVicar; A Shimosaka; Diana Linnekin; Dan Longo; John O'Shea
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Blood 1995;85(12):3444-51.
1995: Maria Grazia Malabarba; Robert A Kirken; Hallgeir Rui; K Koettnitz; M Kawamura; John O'Shea; F S Kalthoff; William L Farrar
Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
The Journal of biological chemistry 1995;270(16):9630-7.
1995: Tiziana Musso; JA Johnston; Diana Linnekin; Luigi Varesio; T K Rowe; John O'Shea; Daniel W McVicar
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.
The Journal of experimental medicine 1995;181(4):1425-31.
1995: C M Bacon; Daniel W McVicar; John R Ortaldo; R C Rees; John O'Shea; JA Johnston
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
The Journal of experimental medicine 1995;181(1):399-404.
1995: John R Ortaldo; Anna T Mason; John O'Shea
Receptor-induced death in human natural killer cells: involvement of CD16.
The Journal of experimental medicine 1995;181(1):339-44.
1994: Tiziana Musso; Luigi Varesio; X Zhang; T K Rowe; Pascual Ferrara; John R Ortaldo; John O'Shea; Daniel W McVicar
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.
The Journal of experimental medicine 1994;180(6):2383-8.
1994: William Murphy; Scott K Durum; M R Anver; Douglass K Ferris; Daniel W McVicar; John O'Shea; S K Ruscetti; M R Smith; Howard A Young; Dan Longo
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1004-14.
1994: JA Johnston; M Kawamura; Robert A Kirken; Y Q Chen; T B Blake; K Shibuya; John R Ortaldo; Daniel W McVicar; John O'Shea
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Nature 1994;370(6485):151-3.
1994: Daniel W McVicar; Brajesh Lal; A Lloyd; M Kawamura; Y Q Chen; X Zhang; J E Staples; J R Ortaldo; John O'Shea
Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.
Oncogene 1994;9(7):2037-44.
1994: D M Eicher; T H Tan; N R Rice; John O'Shea; I C Kennedy
Expression of v-src in T cells correlates with nuclear expression of NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2710-9.
1993: James H Finke; Arnold H Zea; J Stanley; Dan Longo; H Mizoguchi; Raymond R Tubbs; Robert Wiltrout; John O'Shea; S Kudoh; E Klein
Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.
Cancer research 1993;53(23):5613-6.
1992: H Mizoguchi; John O'Shea; Dan Longo; C M Loeffler; D W McVicar; Augusto C Ochoa
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Science (New York, N.Y.) 1992;258(5089):1795-8.
1992: John O'Shea; D W McVicar; T L Bailey; C Burns; M J Smyth
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10306-10.
1992: John O'Shea; Daniel W McVicar; D B Kuhns; John R Ortaldo
A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2497-502.
1992: B B Niklinska; H Yamada; John O'Shea; Carl H June; Jonathan D Ashwell
Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells.
The Journal of biological chemistry 1992;267(10):7154-9.
1992: I C Kennedy; C H June; John O'Shea
Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor.
The Journal of biological chemistry 1992;267(7):4924-9.
1991: O Letourneur; I C Kennedy; A T Brini; John R Ortaldo; John O'Shea; Jean-Pierre Kinet
Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII).
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2652-6.
1991: John R Ortaldo; Anna T Mason; John O'Shea; M J Smyth; L A Falk; I C Kennedy; Dan Longo; F W Ruscetti
Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3791-8.
1991: John O'Shea; J D Ashwell; T L Bailey; S L Cross; L E Samelson; R D Klausner
Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1741-5.
1991: John O'Shea; A M Weissman; I C Kennedy; John R Ortaldo
Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):350-4.
1990: John O'Shea; John R Ortaldo
Killer T's, macrophages, and NK's. The Fourth International Cell-Mediated Cytotoxicity Workshop, sponsored by the Pittsburgh CancerInstitute, and the University of Pittsburgh Medical Health Care Division, Oglebay Park, WV, USA, June 10-13, 1990.
The New biologist 1990;2(9):779-82.
1989: Allan M Weissman; Juan Bonifacino; Richard D Klausner; Lawrence E Samelson; John O'Shea
T cell antigen receptor: structure, assembly and function.
The Year in immunology 1989;4():74-93.
1987: John O'Shea; K B Urdahl; H T Luong; T M Chused; Lawrence E Samelson; Richard D Klausner
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3463-9.
1987: Lawrence E Samelson; John O'Shea; H Luong; P Ross; K B Urdahl; Richard D Klausner; J Bluestone
T cell antigen receptor phosphorylation induced by an anti-receptor antibody.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2708-14.
1987: Richard D Klausner; John O'Shea; H Luong; P Ross; J A Bluestone; Lawrence E Samelson
T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.
The Journal of biological chemistry 1987;262(26):12654-9.
1987: John O'Shea; C A Suárez-Quian; R A Swank; R D Klausner
The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase.
Biochemical and biophysical research communications 1987;146(2):561-7.
1987: C A Suárez-Quian; John O'Shea; R D Klausner
Partially purified phosphatidylinositol kinase does not catalyze the formation of phosphatidylinositol-4,5-bisphosphate.
Biochemical and biophysical research communications 1987;143(2):512-6.
1987: E J Brown; J F Bohnsack; John O'Shea; J McGarr
Evidence for a conformational change in human fibronectin which occurs between 4 and 37 degrees C.
Molecular immunology 1987;24(3):221-30.
1987: John O'Shea; E S Jaffe; H Clifford Lane; R P MacDermott; Anthony Fauci
Peripheral T cell lymphoma presenting as hypereosinophilia with vasculitis. Clinical, pathologic, and immunologic features.
The American journal of medicine 1987;82(3):539-45.
1987: Y Kubota; T A Gaither; J Cason; John O'Shea; T J Lawley
Characterization of the C3 receptor induced by herpes simplex virus type 1 infection of human epidermal, endothelial, and A431 cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(4):1137-42.
1987: R D Klausner; M D Patel; John O'Shea; L E Samelson
Phosphorylation of the T cell antigen receptor: multiple signal transduction pathways.
Journal of cellular physiology. Supplement 1987;Suppl 5():49-51.
1986: John Edwards; T A Gaither; John O'Shea; Daniel Rotrosen; T J Lawley; S A Wright; M M Frank; I Green
Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(11):3577-83.
1986: K Tanaka; John O'Shea; G Finocchiaro; Y Ikeda; D J Aberhart; P K Ghoshal
Substrate stereochemistry of 2-methyl-branched-chain acyl-CoA dehydrogenase: elimination of one hydrogen each from (pro-2S)-methyl and alpha-methine of isobutyryl-CoA.
Biochimica et biophysica acta 1986;873(2):308-11.
1986: John O'Shea; J B Harford; R D Klausner
Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(3):971-6.
1986: L F Fries; John O'Shea; M M Frank
Inherited deficiencies of complement and complement-related proteins.
Clinical immunology and immunopathology 1986;40(1):37-49.
1986: V M Holers; T Seya; E Brown; John O'Shea; J P Atkinson
Structural and functional studies on the human C3b/C4b receptor (CR1) purified by affinity chromatography using a monoclonal antibody.
Complement (Basel, Switzerland) 1986;3(2):63-78.
1985: John O'Shea; S A Siwik; T A Gaither; M M Frank
Activation of the C3b receptor: effect of diacylglycerols and calcium mobilization.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(5):3381-7.
1985: J F Bohnsack; John O'Shea; T Takahashi; E J Brown
Fibronectin-enhanced phagocytosis of an alternative pathway activator by human culture-derived macrophages is mediated by the C4b/C3b complement receptor (CR1).
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2680-6.
1985: M Berger; D L Birx; E M Wetzler; John O'Shea; E J Brown; Alan S Cross
Calcium requirements for increased complement receptor expression during neutrophil activation.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1342-8.
1985: John O'Shea; E J Brown; T A Gaither; T Takahashi; M M Frank
Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1325-30.
1985: T Takahashi; S Inada; C G Pommier; John O'Shea; E J Brown
Osmotic stress and the freeze-thaw cycle cause shedding of Fc and C3b receptors by human polymorphonuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(6):4062-8.
1985: J F Bohnsack; H K Kleinman; T Takahashi; John O'Shea; E J Brown
Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages.
The Journal of experimental medicine 1985;161(5):912-23.
1985: John O'Shea; E J Brown; B E Seligmann; J A Metcalf; M M Frank; John Gallin
Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2580-7.
1984: C G Pommier; John O'Shea; T Chused; K Yancey; M M Frank; T Takahashi; E J Brown
Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.
The Journal of experimental medicine 1984;159(1):137-51.