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John O'Shea

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Physiology

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Mice

Phenomena

Phosphorylation

Anatomy

Disorders

Severe Combined Immunodeficiency

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Publications

TOP 3
Brydges Susannah D; Mueller James L; McGeough Matthew D; Pena Carla A; Misaghi Amirhossein; Gandhi Chhavi; Putnam Chris D; Boyle David L; Firestein Gary S; Horner Anthony A; Soroosh Pejman; Watford Wendy T; O'Shea John J; Kastner Daniel L; Hoffman Hal M
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
O'Shea John J; Steward-Tharp Scott M; Laurence Arian; Watford Wendy T; Wei Lai; Adamson Adewole S; Fan Samuel
Signal transduction and Th17 cell differentiation.
Adamson Adewole S; Collins Kalonji; Laurence Arian; O'Shea John J
The Current STATus of lymphocyte signaling: new roles for old players.

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All Publications

2009: Brydges Susannah D; Mueller James L; McGeough Matthew D; Pena Carla A; Misaghi Amirhossein; Gandhi Chhavi; Putnam Chris D; Boyle David L; Firestein Gary S; Horner Anthony A; Soroosh Pejman; Watford Wendy T; O'Shea John J; Kastner Daniel L; Hoffman Hal M
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Immunity 2009;30(6):875-87.
2009: O'Shea John J; Steward-Tharp Scott M; Laurence Arian; Watford Wendy T; Wei Lai; Adamson Adewole S; Fan Samuel
Signal transduction and Th17 cell differentiation.
Microbes and infection / Institut Pasteur 2009;11(5):599-611.
2009: Adamson Adewole S; Collins Kalonji; Laurence Arian; O'Shea John J
The Current STATus of lymphocyte signaling: new roles for old players.
Current opinion in immunology 2009;21(2):161-6.
2009: Charles Nicolas; Watford Wendy T; Ramos Haydeé L; Hellman Lars; Oettgen Hans C; Gomez Gregorio; Ryan John J; O'Shea John J; Rivera Juan
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.
Immunity 2009;30(4):533-43.
2009: Ghoreschi Kamran; Laurence Arian; O'Shea John J
Selectivity and therapeutic inhibition of kinases: to be or not to be?
Nature immunology 2009;10(4):356-60.
2009: Ghoreschi Kamran; Laurence Arian; O'Shea John J
Janus kinases in immune cell signaling.
Immunological reviews 2009;228(1):273-87.
2009: McGeachy Mandy J; Chen Yi; Tato Cristina M; Laurence Arian; Joyce-Shaikh Barbara; Blumenschein Wendy M; McClanahan Terrill K; O'Shea John J; Cua Daniel J
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
Nature immunology 2009;10(3):314-24.
2009: Wei Gang; Wei Lai; Zhu Jinfang; Zang Chongzhi; Hu-Li Jane; Yao Zhengju; Cui Kairong; Kanno Yuka; Roh Tae-Young; Watford Wendy T; Schones Dustin E; Peng Weiqun; Sun Hong-Wei; Paul William E; O'Shea John J; Zhao Keji
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.
Immunity 2009;30(1):155-67.
2009: Takatori Hiroaki; Kanno Yuka; Watford Wendy T; Tato Cristina M; Weiss Greta; Ivanov Ivaylo I; Littman Dan R; O'Shea John J
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine 2009;206(1):35-41.
2008: Jiang Jian-kang; Ghoreschi Kamran; Deflorian Francesca; Chen Zhi; Perreira Melissa; Pesu Marko; Smith Jeremy; Nguyen Dac-Trung; Liu Eric H; Leister William; Costanzi Stefano; O'Shea John J; Thomas Craig J
Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).
Journal of medicinal chemistry 2008;51(24):8012-8.
2008: Watford Wendy T; Hissong Bruce D; Durant Lydia R; Yamane Hidehiro; Muul Linda M; Kanno Yuka; Tato Cristina M; Ramos Haydeé L; Berger Alan E; Mielke Lisa; Pesu Marko; Solomon Benjamin; Frucht David M; Paul William E; Sher Alan; Jankovic Dragana; Tsichlis Philip N; O'Shea John J
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.
The Journal of experimental medicine 2008;205(12):2803-12.
2008: Andersson John; Tran Dat Q; Pesu Marko; Davidson Todd S; Ramsey Heather; O'Shea John J; Shevach Ethan M
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
The Journal of experimental medicine 2008;205(9):1975-81.
2008: Pesu Marko; Watford Wendy T; Wei Lai; Xu Lili; Fuss Ivan; Strober Warren; Andersson John; Shevach Ethan M; Quezado Martha; Bouladoux Nicolas; Roebroek Anton; Belkaid Yasmine; Creemers John; O'Shea John J
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Nature 2008;455(7210):246-50.
2008: Wei Lai; Laurence Arian; O'Shea John J
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation.
Seminars in cell & developmental biology 2008;19(4):394-400.
2008: Cecchinato V; Trindade C J; Laurence A; Heraud J M; Brenchley J M; Ferrari M G; Zaffiri L; Tryniszewska E; Tsai W P; Vaccari M; Parks R Washington; Venzon D; Douek D C; O'Shea J J; Franchini G
Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques.
Mucosal immunology 2008;1(4):279-88.
2008: Pesu Marko; Laurence Arian; Kishore Nandini; Zwillich Samuel H; Chan Gary; O'Shea John J
Therapeutic targeting of Janus kinases.
Immunological reviews 2008;223():132-42.
2008: Martin Roland; O'Shea John; Birnbaum Linda S; Luebke Robert
Community corner. Striking the balance in multiple sclerosis.
Nature medicine 2008;14(5):491.
2008: O'Shea John J; Hunter Christopher A; Germain Ronald N
T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
Nature immunology 2008;9(5):450-3.
2008: O'Shea John J; Murray Peter J
Cytokine signaling modules in inflammatory responses.
Immunity 2008;28(4):477-87.
2008: Milner Joshua D; Brenchley Jason M; Laurence Arian; Freeman Alexandra F; Hill Brenna J; Elias Kevin M; Kanno Yuka; Spalding Christine; Elloumi Houda Z; Paulson Michelle L; Davis Joie; Hsu Amy; Asher Ava I; O'Shea John; Holland Steven M; Paul William E; Douek Daniel C
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Nature 2008;452(7188):773-6.
2008: Laurence Arian; O'Shea John J; Watford Wendy T
Interleukin-22: a sheep in wolf's clothing.
Nature medicine 2008;14(3):247-9.
2008: Chen Zhi; O'Shea John J
Regulation of IL-17 production in human lymphocytes.
Cytokine 2008;41(2):71-8.
2008: Elias Kevin M; Laurence Arian; Davidson Todd S; Stephens Geoffrey; Kanno Yuka; Shevach Ethan M; O'Shea John J
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
Blood 2008;111(3):1013-20.
2008: Foulds Kathryn E; Rotte Masashi J; Paley Michael A; Singh Babu; Douek Daniel C; Hill Brenna J; O'Shea John J; Watford Wendy T; Seder Robert A; Wu Chang-You
IFN-gamma mediates the death of Th1 cells in a paracrine manner.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):842-9.
2008: Takatori Hiroaki; Kanno Yuka; Chen Zhi; O'Shea John J
New complexities in helper T cell fate determination and the implications for autoimmune diseases.
Modern rheumatology / the Japan Rheumatism Association 2008;18(6):533-41.
2008: Chen Zhi; O'Shea John J
Th17 cells: a new fate for differentiating helper T cells.
Immunologic research 2008;41(2):87-102.
2007: Chen Zhi; Laurence Arian; O'Shea John J
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation.
Seminars in immunology 2007;19(6):400-8.
2007: Stumhofer Jason S; Silver Jonathan S; Laurence Arian; Porrett Paige M; Harris Tajie H; Turka Laurence A; Ernst Matthias; Saris Christiaan J M; O'Shea John J; Hunter Christopher A
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
Nature immunology 2007;8(12):1363-71.
2007: Wei Lai; Laurence Arian; Elias Kevin M; O'Shea John J
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
The Journal of biological chemistry 2007;282(48):34605-10.
2007: Chen Zhi; Tato Cristina M; Muul Linda; Laurence Arian; O'Shea John J
Distinct regulation of interleukin-17 in human T helper lymphocytes.
Arthritis and rheumatism 2007;56(9):2936-46.
2007: Laurence Arian; O'Shea John J
T(H)-17 differentiation: of mice and men.
Nature immunology 2007;8(9):903-5.
2007: Park Heiyoung; Teja Kabir; O'Shea John J; Siegel Richard M
The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6426-34.
2007: Ramos Haydeé L; O'Shea John J; Watford Wendy T
STAT5 isoforms: controversies and clarifications.
The Biochemical journal 2007;404(1):e1-2.
2007: Li Hongjie; Watford Wendy; Li Cuiling; Parmelee Alissa; Bryant Mark A; Deng Chuxia; O'Shea John; Lee Sean Bong
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.
The Journal of clinical investigation 2007;117(5):1314-23.
2007: Yao Zhengju; Kanno Yuka; Kerenyi Marc; Stephens Geoffrey; Durant Lydia; Watford Wendy T; Laurence Arian; Robinson Gertraud W; Shevach Ethan M; Moriggl Richard; Hennighausen Lothar; Wu Changyou; O'Shea John J
Nonredundant roles for Stat5a/b in directly regulating Foxp3.
Blood 2007;109(10):4368-75.
2007: Laurence Arian; Tato Cristina M; Davidson Todd S; Kanno Yuka; Chen Zhi; Yao Zhengju; Blank Rebecca B; Meylan Françoise; Siegel Richard; Hennighausen Lothar; Shevach Ethan M; O'shea John J
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Immunity 2007;26(3):371-81.
2007: Villarino Alejandro V; Tato Cristina M; Stumhofer Jason S; Yao Zhengju; Cui Yongzhi K; Hennighausen Lothar; O'Shea John J; Hunter Christopher A
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
The Journal of experimental medicine 2007;204(1):65-71.
2007: Liu Eric H; Siegel Richard M; Harlan David M; O'Shea John J
T cell-directed therapies: lessons learned and future prospects.
Nature immunology 2007;8(1):25-30.
2006: Watford Wendy T; O'Shea John J
Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.
Immunity 2006;25(5):695-7.
2006: Watford Wendy T; Li Denise; Agnello Davide; Durant Lydia; Yamaoka Kunihiro; Yao Zheng Ju; Ahn Hyun-Jong; Cheng Tammy P; Hofmann Sigrun R; Cogliati Tiziana; Chen Amy; Hissong Bruce D; Husa Matthew R; Schwartzberg Pamela; O'Shea John J; Gadina Massimo
Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.
Molecular and cellular biology 2006;26(17):6623-32.
2006: Stumhofer Jason S; Laurence Arian; Wilson Emma H; Huang Elaine; Tato Cristina M; Johnson Leanne M; Villarino Alejandro V; Huang Qiulong; Yoshimura Akihiko; Sehy David; Saris Christiaan J M; O'Shea John J; Hennighausen Lothar; Ernst Matthias; Hunter Christopher A
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Nature immunology 2006;7(9):937-45.
2006: Pesu Marko; Muul Linda; Kanno Yuka; O'Shea John J
Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.
Blood 2006;108(3):983-5.
2006: Chen Zhi; Laurence Arian; Kanno Yuka; Pacher-Zavisin Margit; Zhu Bing-Mei; Tato Cristina; Yoshimura Akihiko; Hennighausen Lothar; O'Shea John J
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8137-42.
2006: Tato Cristina M; O'Shea John J
Immunology: what does it mean to be just 17?
Nature 2006;441(7090):166-8.
2006: Tato Cristina M; Laurence Arian; O'Shea John J
Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
The Journal of experimental medicine 2006;203(4):809-12.
2006: Usui Takashi; Preiss Jan C; Kanno Yuka; Yao Zheng Ju; Bream Jay H; O'Shea John J; Strober Warren
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.
The Journal of experimental medicine 2006;203(3):755-66.
2006: Yao Zhengju; Cui Yongzhi; Watford Wendy T; Bream Jay H; Yamaoka Kunihiro; Hissong Bruce D; Li Denise; Durum Scott K; Jiang Qiong; Bhandoola Avinash; Hennighausen Lothar; O'Shea John J
Stat5a/b are essential for normal lymphoid development and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1000-5.
2005: Yamaoka Kunihiro; Min Booki; Zhou Yong-Jie; Paul William E; O'shea John J
Jak3 negatively regulates dendritic-cell cytokine production and survival.
Blood 2005;106(9):3227-33.
2005: Pesu Marko; O'Shea John; Hennighausen Lothar; Silvennoinen Olli
Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders.
Molecular interventions 2005;5(4):211-5.
2005: O'Shea John J; Park Heiyoung; Pesu Marko; Borie Dominic; Changelian Paul
New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.
Current opinion in rheumatology 2005;17(3):305-11.
2005: Moriguchi Masato; Hissong Bruce D; Gadina Massimo; Yamaoka Kunihiro; Tiffany H Lee; Murphy Philip M; Candotti Fabio; O'Shea John J
CXCL12 signaling is independent of Jak2 and Jak3.
The Journal of biological chemistry 2005;280(17):17408-14.
2005: Tamura Tomohiko; Tailor Prafullakumar; Yamaoka Kunihiro; Kong Hee Jeong; Tsujimura Hideki; O'Shea John J; Singh Harinder; Ozato Keiko
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2573-81.
2005: Pesu Marko; Candotti Fabio; Husa Matthew; Hofmann Sigrun R; Notarangelo Luigi D; O'Shea John J
Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.
Immunological reviews 2005;203():127-42.
2005: O'Shea John J; Kanno Yuka; Chen Xiaomin; Levy David E
Cell signaling. Stat acetylation--a key facet of cytokine signaling?
Science (New York, N.Y.) 2005;307(5707):217-8.
2004: Watford Wendy T; Hissong Bruce D; Bream Jay H; Kanno Yuka; Muul Linda; O'Shea John J
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Immunological reviews 2004;202():139-56.
2004: Borie Dominic C; O'Shea John J; Changelian Paul S
JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants.
Trends in molecular medicine 2004;10(11):532-41.
2004: O'shea J J
Targeting the Jak/STAT pathway for immunosuppression.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii67-ii71.
2004: O'Shea John J; Watford Wendy
A peek at PIAS.
Nature immunology 2004;5(9):875-6.
2004: Morinobu Akio; Kanno Yuka; O'Shea John J
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression.
The Journal of biological chemistry 2004;279(39):40640-6.
2004: Bream Jay H; Hodge Deborah L; Gonsky Rivkah; Spolski Rosanne; Leonard Warren J; Krebs Stephanie; Targan Stephan; Morinobu Akio; O'Shea John J; Young Howard A
A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
The Journal of biological chemistry 2004;279(39):41249-57.
2004: O'Shea John J; Pesu Marko; Borie Dominic C; Changelian Paul S
A new modality for immunosuppression: targeting the JAK/STAT pathway.
Nature reviews. Drug discovery 2004;3(7):555-64.
2004: O'Shea John J; Husa Matthew; Li Denise; Hofmann Sigrun R; Watford Wendy; Roberts Joseph L; Buckley Rebecca H; Changelian Paul; Candotti Fabio
Jak3 and the pathogenesis of severe combined immunodeficiency.
Molecular immunology 2004;41(6-7):727-37.
2004: Hofmann Sigrun R; Lam Albert Q; Frank Stephan; Zhou Yong-Jie; Ramos Haydeé L; Kanno Yuka; Agnello Davide; Youle Richard J; O'Shea John J
Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.
Molecular and cellular biology 2004;24(11):5039-49.
2004: Wu Zhengqi; Roberts Margaret; Porter Melissa; Walker Fabianne; Wherry E John; Kelly John; Gadina Massimo; Silva Elisabeth M; DosReis George A; Lopes Marcela F; O'Shea John; Leonard Warren J; Ahmed Rafi; Siegel Richard M
Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6313-23.
2004: Kurzer Jason H; Argetsinger Lawrence S; Zhou Yong-Jie; Kouadio Jean-Louis K; O'Shea John J; Carter-Su Christin
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Molecular and cellular biology 2004;24(10):4557-70.
2004: Roberts Joseph L; Lengi Andrea; Brown Stephanie M; Chen Min; Zhou Yong-Jie; O'Shea John J; Buckley Rebecca H
Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.
Blood 2004;103(6):2009-18.
2004: Yamaoka Kunihiro; Saharinen Pipsa; Pesu Marko; Holt Vance E T; Silvennoinen Olli; O'Shea John J
The Janus kinases (Jaks).
Genome biology 2004;5(12):253.
2003: Changelian Paul S; Flanagan Mark E; Ball Douglas J; Kent Craig R; Magnuson Kelly S; Martin William H; Rizzuti Bonnie J; Sawyer Perry S; Perry Bret D; Brissette William H; McCurdy Sandra P; Kudlacz Elizabeth M; Conklyn Maryrose J; Elliott Eileen A; Koslov Erika R; Fisher Michael B; Strelevitz Timothy J; Yoon Kwansik; Whipple David A; Sun Jianmin; Munchhof Michael J; Doty John L; Casavant Jeffrey M; Blumenkopf Todd A; Hines Michael; Brown Matthew F; Lillie Brett M; Subramanyam Chakrapani; Shang-Poa Chang; Milici Anthony J; Beckius Gretchen E; Moyer James D; Su Chunyan; Woodworth Thasia G; Gaweco Anderson S; Beals Chan R; Littman Bruce H; Fisher Douglas A; Smith James F; Zagouras Panayiotis; Magna Holly A; Saltarelli Mary J; Johnson Kimberly S; Nelms Linda F; Des Etages Shelley G; Hayes Lisa S; Kawabata Thomas T; Finco-Kent Deborah; Baker Deanna L; Larson Michael; Si Ming-Sing; Paniagua Ricardo; Higgins John; Holm Bari; Reitz Bruce; Zhou Yong-Jie; Morris Randall E; O'Shea John J; Borie Dominic C
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Science (New York, N.Y.) 2003;302(5646):875-8.
2003: Watford Wendy T; Moriguchi Masato; Morinobu Akio; O'Shea John J
The biology of IL-12: coordinating innate and adaptive immune responses.
Cytokine & growth factor reviews 2003;14(5):361-8.
2003: Boulay Jean-Louis; O'Shea John J; Paul William E
Molecular phylogeny within type I cytokines and their cognate receptors.
Immunity 2003;19(2):159-63.
2003: O'Shea John J; Holland Steven; Candotti Fabio
Primary immunodeficiencies and the rheumatologist.
Current opinion in rheumatology 2003;15(4):413-6.
2003: Aringer Martin; Hofmann Sigrun R; Frucht David M; Chen Min; Centola Michael; Morinobu Akio; Visconti Roberta; Kastner Daniel L; Smolen Josef S; O'Shea John J
Characterization and analysis of the proximal Janus kinase 3 promoter.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6057-64.
2003: Johnston James A; O'Shea John J
Matching SOCS with function.
Nature immunology 2003;4(6):507-9.
2003: Agnello Davide; Lankford Carla S R; Bream Jay; Morinobu Akio; Gadina Massimo; O'Shea John J; Frucht David M
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights.
Journal of clinical immunology 2003;23(3):147-61.
2003: O'Shea John J; Shelbourne K Donald
Repair of locked bucket-handle meniscal tears in knees with chronic anterior cruciate ligament deficiency.
The American journal of sports medicine 2003;31(2):216-20.
2003: Watford Wendy T; O'Shea John J
Autoimmunity: A case of mistaken identity.
Nature 2003;421(6924):706-8.
2003: Moskal Joseph T; O'Shea John J
Intramedullary stabilization of distal-third femur fractures in octogenarians.
Journal of the Southern Orthopaedic Association 2003;12(1):3-8.
2002: Hofmann Sigrun R; Ettinger Rachel; Zhou Yong-Jie; Gadina Massimo; Lipsky Peter; Siegel Richard; Candotti Fabio; O'Shea John J
Cytokines and their role in lymphoid development, differentiation and homeostasis.
Current opinion in allergy and clinical immunology 2002;2(6):495-506.
2002: Aksentijevich Ivona; Nowak Miroslawa; Mallah Mustapha; Chae Jae Jin; Watford Wendy T; Hofmann Sigrun R; Stein Leonard; Russo Ricardo; Goldsmith Donald; Dent Peter; Rosenberg Helene F; Austin Frances; Remmers Elaine F; Balow James E; Rosenzweig Sergio; Komarow Hirsh; Shoham Nitza G; Wood Geryl; Jones Janet; Mangra Nadira; Carrero Hector; Adams Barbara S; Moore Terry L; Schikler Kenneth; Hoffman Hal; Lovell Daniel J; Lipnick Robert; Barron Karyl; O'Shea John J; Kastner Daniel L; Goldbach-Mansky Raphaela
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
Arthritis and rheumatism 2002;46(12):3340-8.
2002: Nishikomori Ryuta; Usui Takashi; Wu Chang-Yu; Morinobu Akio; O'Shea John J; Strober Warren
Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4388-98.
2002: Nguyen Khuong B; Watford Wendy T; Salomon Rachelle; Hofmann Sigrun R; Pien Gary C; Morinobu Akio; Gadina Massimo; O'Shea John J; Biron Christine A
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
Science (New York, N.Y.) 2002;297(5589):2063-6.
2002: Morinobu Akio; Gadina Massimo; Strober Warren; Visconti Roberta; Fornace Albert; Montagna Cristina; Feldman Gerald M; Nishikomori Ryuta; O'Shea John J
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12281-6.
2002: Parravicini Valentino; Gadina Massimo; Kovarova Martina; Odom Sandra; Gonzalez-Espinosa Claudia; Furumoto Yasuko; Saitoh Shinichiroh; Samelson Lawrence E; O'Shea John J; Rivera Juan
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Nature immunology 2002;3(8):741-8.
2002: O'Shea John J; Paul William E
Regulation of T(H)1 differentiation--controlling the controllers.
Nature immunology 2002;3(6):506-8.
2002: Candotti Fabio; Notarangelo Luigi; Visconti Roberta; O'Shea John
Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.
The Journal of clinical investigation 2002;109(10):1261-9.
2002: O'Shea John J; Gadina Massimo; Schreiber Robert D
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
Cell 2002;109 Suppl():S121-31.
2002: O'Shea John J; Shelbourne K Donald
Anterior cruciate ligament reconstruction with a reharvested bone-patellar tendon-bone graft.
The American journal of sports medicine 2002;30(2):208-13.
2002: Tang Pingtao; Cheng Tammy P; Agnello Davide; Wu Chang-You; Hissong Bruce D; Watford Wendy T; Ahn Hyun-Jong; Galon Jerome; Moss Joel; Vaughan Martha; O'Shea John J; Gadina Massimo
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2625-9.
2002: Franchimont Denis; Galon Jérôme; Vacchio Melanie S; Fan Samuel; Visconti Roberta; Frucht David M; Geenen Vincent; Chrousos George P; Ashwell Jonathan D; O'Shea John J
Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2212-8.
2002: O'Brien Karen B; O'Shea John J; Carter-Su Christin
SH2-B family members differentially regulate JAK family tyrosine kinases.
The Journal of biological chemistry 2002;277(10):8673-81.
2002: O'Shea John J; Ma Averil; Lipsky Peter
Cytokines and autoimmunity.
Nature reviews. Immunology 2002;2(1):37-45.
2002: Galon Jerome; Franchimont Denis; Hiroi Naoki; Frey Gregory; Boettner Antje; Ehrhart-Bornstein Monika; O'Shea John J; Chrousos George P; Bornstein Stefan R
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):61-71.
2002: Mittelstadt P R; Galon J; Franchimont D; O'Shea J J; Ashwell J D
Glucocorticoid-inducible genes that regulate T-cell function.
Ernst Schering Research Foundation workshop 2002;(40):319-39.
2002: Shelbourne K Donald; O'Shea John J
Revision anterior cruciate ligament reconstruction using the contralateral bone-patellar tendon-bone graft.
Instructional course lectures 2002;51():343-6.
2001: Frucht D M; Gadina M; Jagadeesh G J; Aksentijevich I; Takada K; Bleesing J J; Nelson J; Muul L M; Perham G; Morgan G; Gerritsen E J; Schumacher R F; Mella P; Veys P A; Fleisher T A; Kaminski E R; Notarangelo L D; O'Shea J J; Candotti F
Unexpected and variable phenotypes in a family with JAK3 deficiency.
Genes and immunity 2001;2(8):422-32.
2001: Lighvani A A; Frucht D M; Jankovic D; Yamane H; Aliberti J; Hissong B D; Nguyen B V; Gadina M; Sher A; Paul W E; O'Shea J J
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15137-42.
2001: O'Shea J J; Johnston J A; Kehrl J; Koretzky G; Samelson L E
Key molecules involved in receptor-mediated lymphocyte activation.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 11():Unit 11.9A.
2001: Zhou Y J; Chen M; Cusack N A; Kimmel L H; Magnuson K S; Boyd J G; Lin W; Roberts J L; Lengi A; Buckley R H; Geahlen R L; Candotti F; Gadina M; Changelian P S; O'Shea J J
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
Molecular cell 2001;8(5):959-69.
2001: Kastner D L; O'Shea J J
A fever gene comes in from the cold.
Nature genetics 2001;29(3):241-2.
2001: Frucht D M; Fukao T; Bogdan C; Schindler H; O'Shea J J; Koyasu S
IFN-gamma production by antigen-presenting cells: mechanisms emerge.
Trends in immunology 2001;22(10):556-60.
2001: Aksentijevich I; Galon J; Soares M; Mansfield E; Hull K; Oh H H; Goldbach-Mansky R; Dean J; Athreya B; Reginato A J; Henrickson M; Pons-Estel B; O'Shea J J; Kastner D L
The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.
American journal of human genetics 2001;69(2):301-14.
2001: Tomita K; Saijo K; Yamasaki S; Iida T; Nakatsu F; Arase H; Ohno H; Shirasawa T; Kuriyama T; O'Shea J J; Saito T
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex.
The Journal of biological chemistry 2001;276(27):25378-85.
2001: Gadina M; Hilton D; Johnston J A; Morinobu A; Lighvani A; Zhou Y J; Visconti R; O'Shea J J
Signaling by type I and II cytokine receptors: ten years after.
Current opinion in immunology 2001;13(3):363-73.
2001: Fukao T; Frucht D M; Yap G; Gadina M; O'Shea J J; Koyasu S
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4446-55.
2001: Monson N L; Fenske T J; Wei S; Okragly A J; de Jong J L; Haak-Frendscho M; O'Shea J; Djeu J; Sondel P M
A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2.
Journal of leukocyte biology 2001;69(3):419-25.
2000: Wu C; Wang X; Gadina M; O'Shea J J; Presky D H; Magram J
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6221-8.
2000: O'Shea J J; Visconti R; Cheng T P; Gadina M
Jaks and stats as therapeutic targets.
Annals of the rheumatic diseases 2000;59 Suppl 1():i115-8.
2000: Visconti R; Gadina M; Chiariello M; Chen E H; Stancato L F; Gutkind J S; O'Shea J J
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Blood 2000;96(5):1844-52.
2000: Gadina M; Sudarshan C; Visconti R; Zhou Y J; Gu H; Neel B G; O'Shea J J
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
The Journal of biological chemistry 2000;275(35):26959-66.
2000: Vihinen M; Villa A; Mella P; Schumacher R F; Savoldi G; O'Shea J J; Candotti F; Notarangelo L D
Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency.
Clinical immunology (Orlando, Fla.) 2000;96(2):108-18.
2000: Galon J; Aksentijevich I; McDermott M F; O'Shea J J; Kastner D L
TNFRSF1A mutations and autoinflammatory syndromes.
Current opinion in immunology 2000;12(4):479-86.
2000: Endo K; Takeshita T; Kasai H; Sasaki Y; Tanaka N; Asao H; Kikuchi K; Yamada M; Chenb M; O'Shea J J; Sugamura K
STAM2, a new member of the STAM family, binding to the Janus kinases.
FEBS letters 2000;477(1-2):55-61.
2000: O'Shea J J; Visconti R
Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge.
Nature immunology 2000;1(1):17-9.
2000: Zhou Y J; Magnuson K S; Cheng T P; Gadina M; Frucht D M; Galon J; Candotti F; Geahlen R L; Changelian P S; O'Shea J J
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
Molecular and cellular biology 2000;20(12):4371-80.
2000: Wu C Y; Gadina M; Wang K; O'Shea J; Seder R A
Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells.
European journal of immunology 2000;30(5):1364-74.
2000: Centola M; Wood G; Frucht D M; Galon J; Aringer M; Farrell C; Kingma D W; Horwitz M E; Mansfield E; Holland S M; O'Shea J J; Rosenberg H F; Malech H L; Kastner D L
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
Blood 2000;95(10):3223-31.
2000: Frucht D M; Aringer M; Galon J; Danning C; Brown M; Fan S; Centola M; Wu C Y; Yamada N; El Gabalawy H; O'Shea J J
Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4659-64.
2000: Otsu M; Anderson S M; Bodine D M; Puck J M; O'Shea J J; Candotti F
Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(2):145-53.
2000: Franchimont D; Galon J; Gadina M; Visconti R; Zhou Y; Aringer M; Frucht D M; Chrousos G P; O'Shea J J
Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1768-74.
2000: Chen M; Cheng A; Candotti F; Zhou Y J; Hymel A; Fasth A; Notarangelo L D; O'Shea J J
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.
Molecular and cellular biology 2000;20(3):947-56.
2000: Schumacher R F; Mella P; Badolato R; Fiorini M; Savoldi G; Giliani S; Villa A; Candotti F; Tampalini A; O'Shea J J; Notarangelo L D
Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism.
Human genetics 2000;106(1):73-9.
2000: Contursi C; Wang I M; Gabriele L; Gadina M; O'Shea J; Morse H C; Ozato K
IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):91-6.
2000: Ortmann R A; Cheng T; Visconti R; Frucht D M; O'Shea J J
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.
Arthritis research 2000;2(1):16-32.
2000: O'Shea J J
Something happens; a brief history of TCR signal transduction.
Methods in molecular biology (Clifton, N.J.) 2000;134():197-207.
1999: Galon J; Sudarshan C; Ito S; Finbloom D; O'Shea J J
IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7256-62.
1999: Chen E; Gadina M; Chen M; O'Shea J J
Advances in cytokine signaling: the role of Jaks and STATs.
Transplantation proceedings 1999;31(3):1482-7.
1999: McDermott M F; Aksentijevich I; Galon J; McDermott E M; Ogunkolade B W; Centola M; Mansfield E; Gadina M; Karenko L; Pettersson T; McCarthy J; Frucht D M; Aringer M; Torosyan Y; Teppo A M; Wilson M; Karaarslan H M; Wan Y; Todd I; Wood G; Schlimgen R; Kumarajeewa T R; Cooper S M; Vella J P; Amos C I; Mulley J; Quane K A; Molloy M G; Ranki A; Powell R J; Hitman G A; O'Shea J J; Kastner D L
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.
Cell 1999;97(1):133-44.
1999: Kolenko V; Rayman P; Roy B; Cathcart M K; O'Shea J; Tubbs R; Rybicki L; Bukowski R; Finke J
Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway.
Blood 1999;93(7):2308-18.
1999: Cacalano N A; Migone T S; Bazan F; Hanson E P; Chen M; Candotti F; O'Shea J J; Johnston J A
Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
The EMBO journal 1999;18(6):1549-58.
1999: Sudarshan C; Galon J; Zhou Y; O'Shea J J
TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2974-81.
1999: Gadina M; Sudarshan C; O'Shea J J
IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2081-6.
1999: Aringer M; Cheng A; Nelson J W; Chen M; Sudarshan C; Zhou Y J; O'Shea J J
Janus kinases and their role in growth and disease.
Life sciences 1999;64(24):2173-86.
1998: Waldmann T A; O'Shea J
The use of antibodies against the IL-2 receptor in transplantation.
Current opinion in immunology 1998;10(5):507-12.
1998: Bozzi F; Lefranc G; Villa A; Badolato R; Schumacher R F; Khalil G; Loiselet J; Bresciani S; O'Shea J J; Vezzoni P; Notarangelo L D; Candotti F
Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment.
British journal of haematology 1998;102(5):1363-6.
1998: Chen E H; Gadina M; Galon J; Chen M; O'Shea J J
Not just another meeting: the coming of age of JAKs and STATs.
Immunology today 1998;19(8):338-41.
1998: Gadina M; Stancato L M; Bacon C M; Larner A C; O'Shea J J
Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4657-61.
1998: Candotti F; O'Shea J J; Villa A
Severe combined immune deficiencies due to defects of the common gamma chain-JAK3 signaling pathway.
Springer seminars in immunopathology 1998;19(4):401-15.
1998: Leonard W J; O'Shea J J
Jaks and STATs: biological implications.
Annual review of immunology 1998;16():293-322.
1997: Zhou Y J; Hanson E P; Chen Y Q; Magnuson K; Chen M; Swann P G; Wange R L; Changelian P S; O'Shea J J
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13850-5.
1997: O'Shea J J; Notarangelo L D; Johnston J A; Candotti F
Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.
Journal of clinical immunology 1997;17(6):431-47.
1997: Candotti F; Oakes S A; Johnston J A; Giliani S; Schumacher R F; Mella P; Fiorini M; Ugazio A G; Badolato R; Notarangelo L D; Bozzi F; Macchi P; Strina D; Vezzoni P; Blaese R M; O'Shea J J; Villa A
Structural and functional basis for JAK3-deficient severe combined immunodeficiency.
Blood 1997;90(10):3996-4003.
1997: Kolenko V; Wang Q; Riedy M C; O'Shea J; Ritz J; Cathcart M K; Rayman P; Tubbs R; Edinger M; Novick A; Bukowski R; Finke J
Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):3057-67.
1997: O'Shea J J
Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?
Immunity 1997;7(1):1-11.
1997: Chen M; Cheng A; Chen Y Q; Hymel A; Hanson E P; Kimmel L; Minami Y; Taniguchi T; Changelian P S; O'Shea J J
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6910-5.
1997: Sharfe N; Dadi H K; O'Shea J J; Roifman C M
Jak3 activation in human lymphocyte precursor cells.
Clinical and experimental immunology 1997;108(3):552-6.
1997: Taylor N; Candotti F; Smith S; Oakes S A; Jahn T; Isakov J; Puck J M; O'Shea J J; Weinberg K; Johnston J A
Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency.
The Journal of biological chemistry 1997;272(11):7314-9.
1996: Oakes S A; Candotti F; Johnston J A; Chen Y Q; Ryan J J; Taylor N; Liu X; Hennighausen L; Notarangelo L D; Paul W E; Blaese R M; O'Shea J J
Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.
Immunity 1996;5(6):605-15.
1996: Cho S S; Bacon C M; Sudarshan C; Rees R C; Finbloom D; Pine R; O'Shea J J
Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):4781-9.
1996: Bacon C M; Cho S S; O'Shea J J
Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast.
Annals of the New York Academy of Sciences 1996;795():41-59.
1996: Riedy M C; Dutra A S; Blake T B; Modi W; Lal B K; Davis J; Bosse A; O'Shea J J; Johnston J A
Genomic sequence, organization, and chromosomal localization of human JAK3.
Genomics 1996;37(1):57-61.
1996: Johnston J A; Bacon C M; Riedy M C; O'Shea J J
Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency.
Journal of leukocyte biology 1996;60(4):441-52.
1996: Candotti F; Oakes S A; Johnston J A; Notarangelo L D; O'Shea J J; Blaese R M
In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.
The Journal of experimental medicine 1996;183(6):2687-92.
1996: McVicar D W; Blake T B; Burns C M; Conlon K C; Ortaldo J R; O'Shea J J
Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells: a biochemical correlate of lymphoid functional activity.
Cellular immunology 1996;169(2):302-8.
1996: Candotti F; Johnston J A; Puck J M; Sugamura K; O'Shea J J; Blaese R M
Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.
Blood 1996;87(8):3097-102.
1995: Tortolani P J; Lal B K; Riva A; Johnston J A; Chen Y Q; Reaman G H; Beckwith M; Longo D; Ortaldo J R; Bhatia K; McGrath I; Kehrl J; Tuscano J; McVicar D W; O'Shea J J
Regulation of JAK3 expression and activation in human B cells and B cell malignancies.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5220-6.
1995: Evans G A; Goldsmith M A; Johnston J A; Xu W; Weiler S R; Erwin R; Howard O M; Abraham R T; O'Shea J J; Greene W C
Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association.
The Journal of biological chemistry 1995;270(48):28858-63.
1995: Johnston J A; Wang L M; Hanson E P; Sun X J; White M F; Oakes S A; Pierce J H; O'Shea J J
Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
The Journal of biological chemistry 1995;270(48):28527-30.
1995: Zea A H; Curti B D; Longo D L; Alvord W G; Strobl S L; Mizoguchi H; Creekmore S P; O'Shea J J; Powers G C; Urba W J
Alterations in T cell receptor and signal transduction molecules in melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1327-35.
1995: Russell S M; Tayebi N; Nakajima H; Riedy M C; Roberts J L; Aman M J; Migone T S; Noguchi M; Markert M L; Buckley R H; O'Shea J J; Leonard W J
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
Science (New York, N.Y.) 1995;270(5237):797-800.
1995: Kirken R A; Rui H; Malabarba M G; Howard O M; Kawamura M; O'Shea J J; Farrar W L
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
Cytokine 1995;7(7):689-700.
1995: Macchi P; Villa A; Giliani S; Sacco M G; Frattini A; Porta F; Ugazio A G; Johnston J A; Candotti F; O'Shea J J
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).
Nature 1995;377(6544):65-8.
1995: Xu X; Kang S H; Heidenreich O; Okerholm M; O'Shea J J; Nerenberg M I
Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.
The Journal of clinical investigation 1995;96(3):1548-55.
1995: Bacon C M; Petricoin E F; Ortaldo J R; Rees R C; Larner A C; Johnston J A; O'Shea J J
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7307-11.
1995: Bacon C M; Tortolani P J; Shimosaka A; Rees R C; Longo D L; O'Shea J J
Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3.
FEBS letters 1995;370(1-2):63-8.
1995: Keegan A D; Johnston J A; Tortolani P J; McReynolds L J; Kinzer C; O'Shea J J; Paul W E
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7681-5.
1995: Migone T S; Lin J X; Cereseto A; Mulloy J C; O'Shea J J; Franchini G; Leonard W J
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
Science (New York, N.Y.) 1995;269(5220):79-81.
1995: Tortolani P J; Johnston J A; Bacon C M; McVicar D W; Shimosaka A; Linnekin D; Longo D L; O'Shea J J
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Blood 1995;85(12):3444-51.
1995: Malabarba M G; Kirken R A; Rui H; Koettnitz K; Kawamura M; O'Shea J J; Kalthoff F S; Farrar W L
Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
The Journal of biological chemistry 1995;270(16):9630-7.
1995: Musso T; Johnston J A; Linnekin D; Varesio L; Rowe T K; O'Shea J J; McVicar D W
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.
The Journal of experimental medicine 1995;181(4):1425-31.
1995: Bacon C M; McVicar D W; Ortaldo J R; Rees R C; O'Shea J J; Johnston J A
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
The Journal of experimental medicine 1995;181(1):399-404.
1995: Ortaldo J R; Mason A T; O'Shea J J
Receptor-induced death in human natural killer cells: involvement of CD16.
The Journal of experimental medicine 1995;181(1):339-44.
1994: Musso T; Varesio L; Zhang X; Rowe T K; Ferrara P; Ortaldo J R; O'Shea J J; McVicar D W
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.
The Journal of experimental medicine 1994;180(6):2383-8.
1994: Murphy W J; Durum S K; Anver M R; Ferris D K; McVicar D W; O'Shea J J; Ruscetti S K; Smith M R; Young H A; Longo D L
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1004-14.
1994: Johnston J A; Kawamura M; Kirken R A; Chen Y Q; Blake T B; Shibuya K; Ortaldo J R; McVicar D W; O'Shea J J
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Nature 1994;370(6485):151-3.
1994: McVicar D W; Lal B K; Lloyd A; Kawamura M; Chen Y Q; Zhang X; Staples J E; Ortaldo J R; O'Shea J J
Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.
Oncogene 1994;9(7):2037-44.
1994: Eicher D M; Tan T H; Rice N R; O'Shea J J; Kennedy I C
Expression of v-src in T cells correlates with nuclear expression of NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2710-9.
1993: Finke J H; Zea A H; Stanley J; Longo D L; Mizoguchi H; Tubbs R R; Wiltrout R H; O'Shea J J; Kudoh S; Klein E
Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.
Cancer research 1993;53(23):5613-6.
1992: Mizoguchi H; O'Shea J J; Longo D L; Loeffler C M; McVicar D W; Ochoa A C
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Science (New York, N.Y.) 1992;258(5089):1795-8.
1992: O'Shea J J; McVicar D W; Bailey T L; Burns C; Smyth M J
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10306-10.
1992: Niklinska B B; Yamada H; O'Shea J J; June C H; Ashwell J D
Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells.
The Journal of biological chemistry 1992;267(10):7154-9.
1992: O'Shea J J; McVicar D W; Kuhns D B; Ortaldo J R
A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2497-502.
1992: Kennedy I C; June C H; O'Shea J J
Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor.
The Journal of biological chemistry 1992;267(7):4924-9.
1991: Letourneur O; Kennedy I C; Brini A T; Ortaldo J R; O'Shea J J; Kinet J P
Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII).
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2652-6.
1991: Ortaldo J R; Mason A T; O'Shea J J; Smyth M J; Falk L A; Kennedy I C; Longo D L; Ruscetti F W
Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3791-8.
1991: O'Shea J J; Ashwell J D; Bailey T L; Cross S L; Samelson L E; Klausner R D
Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1741-5.
1991: O'Shea J J; Weissman A M; Kennedy I C; Ortaldo J R
Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):350-4.
1990: O'Shea J J; Ortaldo J R
Killer T's, macrophages, and NK's. The Fourth International Cell-Mediated Cytotoxicity Workshop, sponsored by the Pittsburgh CancerInstitute, and the University of Pittsburgh Medical Health Care Division, Oglebay Park, WV, USA, June 10-13, 1990.
The New biologist 1990;2(9):779-82.
1989: Weissman A M; Bonifacino J S; Klausner R D; Samelson L E; O'Shea J J
T cell antigen receptor: structure, assembly and function.
The Year in immunology 1989;4():74-93.
1987: O'Shea J J; Urdahl K B; Luong H T; Chused T M; Samelson L E; Klausner R D
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3463-9.
1987: Samelson L E; O'Shea J J; Luong H; Ross P; Urdahl K B; Klausner R D; Bluestone J
T cell antigen receptor phosphorylation induced by an anti-receptor antibody.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2708-14.
1987: Klausner R D; O'Shea J J; Luong H; Ross P; Bluestone J A; Samelson L E
T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.
The Journal of biological chemistry 1987;262(26):12654-9.
1987: O'Shea J J; Suárez-Quian C A; Swank R A; Klausner R D
The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase.
Biochemical and biophysical research communications 1987;146(2):561-7.
1987: Brown E J; Bohnsack J F; O'Shea J J; McGarr J
Evidence for a conformational change in human fibronectin which occurs between 4 and 37 degrees C.
Molecular immunology 1987;24(3):221-30.
1987: O'Shea J J; Jaffe E S; Lane H C; MacDermott R P; Fauci A S
Peripheral T cell lymphoma presenting as hypereosinophilia with vasculitis. Clinical, pathologic, and immunologic features.
The American journal of medicine 1987;82(3):539-45.
1987: Suárez-Quian C A; O'Shea J J; Klausner R D
Partially purified phosphatidylinositol kinase does not catalyze the formation of phosphatidylinositol-4,5-bisphosphate.
Biochemical and biophysical research communications 1987;143(2):512-6.
1987: Kubota Y; Gaither T A; Cason J; O'Shea J J; Lawley T J
Characterization of the C3 receptor induced by herpes simplex virus type 1 infection of human epidermal, endothelial, and A431 cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(4):1137-42.
1987: Klausner R D; Patel M D; O'Shea J J; Samelson L E
Phosphorylation of the T cell antigen receptor: multiple signal transduction pathways.
Journal of cellular physiology. Supplement 1987;Suppl 5():49-51.
1986: Edwards J E; Gaither T A; O'Shea J J; Rotrosen D; Lawley T J; Wright S A; Frank M M; Green I
Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(11):3577-83.
1986: Tanaka K; O'Shea J J; Finocchiaro G; Ikeda Y; Aberhart D J; Ghoshal P K
Substrate stereochemistry of 2-methyl-branched-chain acyl-CoA dehydrogenase: elimination of one hydrogen each from (pro-2S)-methyl and alpha-methine of isobutyryl-CoA.
Biochimica et biophysica acta 1986;873(2):308-11.
1986: O'Shea J J; Harford J B; Klausner R D
Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(3):971-6.
1986: Fries L F; O'Shea J J; Frank M M
Inherited deficiencies of complement and complement-related proteins.
Clinical immunology and immunopathology 1986;40(1):37-49.
1986: Holers V M; Seya T; Brown E; O'Shea J J; Atkinson J P
Structural and functional studies on the human C3b/C4b receptor (CR1) purified by affinity chromatography using a monoclonal antibody.
Complement (Basel, Switzerland) 1986;3(2):63-78.
1985: O'Shea J J; Siwik S A; Gaither T A; Frank M M
Activation of the C3b receptor: effect of diacylglycerols and calcium mobilization.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(5):3381-7.
1985: Bohnsack J F; O'Shea J J; Takahashi T; Brown E J
Fibronectin-enhanced phagocytosis of an alternative pathway activator by human culture-derived macrophages is mediated by the C4b/C3b complement receptor (CR1).
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2680-6.
1985: Berger M; Birx D L; Wetzler E M; O'Shea J J; Brown E J; Cross A S
Calcium requirements for increased complement receptor expression during neutrophil activation.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1342-8.
1985: O'Shea J J; Brown E J; Gaither T A; Takahashi T; Frank M M
Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1325-30.
1985: Takahashi T; Inada S; Pommier C G; O'Shea J J; Brown E J
Osmotic stress and the freeze-thaw cycle cause shedding of Fc and C3b receptors by human polymorphonuclear leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(6):4062-8.
1985: Bohnsack J F; Kleinman H K; Takahashi T; O'Shea J J; Brown E J
Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages.
The Journal of experimental medicine 1985;161(5):912-23.
1985: O'Shea J J; Brown E J; Seligmann B E; Metcalf J A; Frank M M; Gallin J I
Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2580-7.
1984: Pommier C G; O'Shea J; Chused T; Yancey K; Frank M M; Takahashi T; Brown E J
Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.
The Journal of experimental medicine 1984;159(1):137-51.

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