Ira Pastan

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Cereda Vittore; Poole Diane J; Palena Claudia; Das Sudipto; Bera Tapan K; Remondo Cinzia; Gulley James L; Arlen Philip M; Yokokawa Junko; Pastan Ira; Schlom Jeffrey; Tsang Kwong Y
New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy.
Kreitman Robert J; Fitzgerald David J P; Pastan Ira
Approach to the patient after relapse of hairy cell leukemia.
Liu Xiu Fen; Bera Tapan K; Liu Lisa J; Pastan Ira
A primate-specific POTE-actin fusion protein plays a role in apoptosis.

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All Publications

2010: Cereda Vittore; Poole Diane J; Palena Claudia; Das Sudipto; Bera Tapan K; Remondo Cinzia; Gulley James L; Arlen Philip M; Yokokawa Junko; Pastan Ira; Schlom Jeffrey; Tsang Kwong Y
New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2010;59(1):63-71.
2009: Kreitman Robert J; Fitzgerald David J P; Pastan Ira
Approach to the patient after relapse of hairy cell leukemia.
Leukemia & lymphoma 2009;50 Suppl 1():32-7.
2009: Liu Xiu Fen; Bera Tapan K; Liu Lisa J; Pastan Ira
A primate-specific POTE-actin fusion protein plays a role in apoptosis.
Apoptosis : an international journal on programmed cell death 2009;14(10):1237-44.
2009: Nagata Satoshi; Pastan Ira
Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics.
Advanced drug delivery reviews 2009;61(11):977-85.
2009: Kreitman Robert J; Hassan Raffit; Fitzgerald David J; Pastan Ira
Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5274-9.
2009: Hahn Yoonsoo; Kim Dong Seon; Pastan Ira H; Lee Byungkook
Anoctamin and transmembrane channel-like proteins are evolutionarily related.
International journal of molecular medicine 2009;24(1):51-5.
2009: Nagata Satoshi; Ise Tomoko; Pastan Ira
Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7518-26.
2009: Kreitman Robert J; Stetler-Stevenson Maryalice; Margulies Inger; Noel Pierre; Fitzgerald David J P; Wilson Wyndham H; Pastan Ira
Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):2983-90.
2009: Weldon John E; Xiang Laiman; Chertov Oleg; Margulies Inger; Kreitman Robert J; FitzGerald David J; Pastan Ira
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.
Blood 2009;113(16):3792-800.
2009: Anaganti Suresh; Hansen Johanna K; Ha Duc; Hahn Yoonsoo; Chertov Oleg; Pastan Ira; Bera Tapan K
Non-AUG translational initiation of a short CAPC transcript generating protein isoform.
Biochemical and biophysical research communications 2009;380(3):508-13.
2009: Carpenito Carmine; Milone Michael C; Hassan Raffit; Simonet Jacqueline C; Lakhal Mehdi; Suhoski Megan M; Varela-Rohena Angel; Haines Kathleen M; Heitjan Daniel F; Albelda Steven M; Carroll Richard G; Riley James L; Pastan Ira; June Carl H
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3360-5.
2009: Alderson Ralph F; Kreitman Robert J; Chen Tianling; Yeung Peter; Herbst Ronald; Fox Judy A; Pastan Ira
CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):832-9.
2009: Ho Mitchell; Pastan Ira
Display and selection of scFv antibodies on HEK-293T cells.
Methods in molecular biology (Clifton, N.J.) 2009;562():99-113.
2009: Ho Mitchell; Pastan Ira
In vitro antibody affinity maturation targeting germline hotspots.
Methods in molecular biology (Clifton, N.J.) 2009;525():293-308, xiv.
2009: Ho Mitchell; Pastan Ira
Mammalian cell display for antibody engineering.
Methods in molecular biology (Clifton, N.J.) 2009;525():337-52, xiv.
2009: Sathyanarayana Bangalore K; Hahn Yoonsoo; Patankar Manish S; Pastan Ira; Lee Byungkook
Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats.
BMC structural biology 2009;9():1.
2008: Zhang Yujian; Pastan Ira
High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(24):7981-6.
2008: Motoyoshi Yaeko; Matsusaka Taiji; Saito Akihiko; Pastan Ira; Willnow Thomas E; Mizutani Shuki; Ichikawa Iekuni
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Kidney international 2008;74(10):1262-9.
2008: Onda Masanori; Beers Richard; Xiang Laiman; Nagata Satoshi; Wang Qing-Cheng; Pastan Ira
An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11311-6.
2008: Das Sudipto; Hahn Yoonsoo; Walker Dawn A; Nagata Satoshi; Willingham Mark C; Peehl Donna M; Bera Tapan K; Lee Byungkook; Pastan Ira
Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.
Cancer research 2008;68(15):6306-12.
2008: Du Xing; Beers Richard; Fitzgerald David J; Pastan Ira
Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity.
Cancer research 2008;68(15):6300-5.
2008: Epel Malka; Carmi Irit; Soueid-Baumgarten Sharon; Oh Sang Kon; Bera Tapan; Pastan Ira; Berzofsky Jay; Reiter Yoram
Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.
European journal of immunology 2008;38(6):1706-20.
2008: Sampson John H; Akabani Gamal; Archer Gerald E; Berger Mitchel S; Coleman R Edward; Friedman Allan H; Friedman Henry S; Greer Kim; Herndon James E; Kunwar Sandeep; McLendon Roger E; Paolino Alison; Petry Neil A; Provenzale James M; Reardon David A; Wong Terence Z; Zalutsky Michael R; Pastan Ira; Bigner Darell D
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
Neuro-oncology 2008;10(3):320-9.
2008: Levitin Fiana; Weiss Mordechai; Hahn Yoonsoo; Stern Omer; Papke Roger L; Matusik Robert; Nandana Srinivas R; Ziv Ravit; Pichinuk Edward; Salame Sharbel; Bera Tapan; Vincent James; Lee Byungkook; Pastan Ira; Wreschner Daniel H
PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.
The Journal of biological chemistry 2008;283(24):16928-39.
2008: Hafkemeyer Peter; Brinkmann Ulrich; Brinkmann Elizabeth; Pastan Ira; Blum Hubert-E; Baumert Thomas-F
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
World journal of gastroenterology : WJG 2008;14(18):2810-7.
2008: Bera Tapan K; Saint Fleur Ashley; Ha Duc; Yamada Masanori; Lee Yoomi; Lee Byungkook; Hahn Yoonsoo; Kaufman Dan S; Pera Martin; Pastan Ira
Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.
Stem cells and development 2008;17(2):325-32.
2008: Khaibullina Alfia; Jang Beom-Su; Sun Haihao; Le Nhat; Yu Sarah; Frenkel Victor; Carrasquillo Jorge A; Pastan Ira; Li King C P; Paik Chang H
Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(2):295-302.
2008: Bera Tapan K; Liu Xiu-Fen; Yamada Masanori; Gavrilova Oksana; Mezey Eva; Tessarollo Lino; Anver Miriam; Hahn Yoonsoo; Lee Byungkook; Pastan Ira
A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):270-5.
2008: Ise Tomoko; Das Sudipto; Nagata Satoshi; Maeda Hiroshi; Lee Yoomi; Onda Masanori; Anver Miriam R; Bera Tapan K; Pastan Ira
Expression of POTE protein in human testis detected by novel monoclonal antibodies.
Biochemical and biophysical research communications 2008;365(4):603-8.
2008: Du Xing; Nagata Satoshi; Ise Tomoko; Stetler-Stevenson Maryalice; Pastan Ira
FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins.
Blood 2008;111(1):338-43.
2008: Ochiai Hidenobu; Archer Gary E; Herndon James E; Kuan Chien-Tsun; Mitchell Duane A; Bigner Darell D; Pastan Ira H; Sampson John H
EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.
Cancer immunology, immunotherapy : CII 2008;57(1):115-21.
2007: Das Sudipto; Ise Tomoko; Nagata Satoshi; Maeda Hiroshi; Bera Tapan K; Pastan Ira
Palmitoylation of POTE family proteins for plasma membrane targeting.
Biochemical and biophysical research communications 2007;363(3):751-6.
2007: Zhang Yujian; Xiang Laiman; Hassan Raffit; Pastan Ira
Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17099-104.
2007: Powell Daniel J; Felipe-Silva Aloisio; Merino Maria J; Ahmadzadeh Mojgan; Allen Tamika; Levy Catherine; White Donald E; Mavroukakis Sharon; Kreitman Robert J; Rosenberg Steven A; Pastan Ira
Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4919-28.
2007: Steinbach Daniel; Onda Masanori; Voigt Astrid; Dawczynski Kristin; Wittig Susan; Hassan Raffit; Gruhn Bernd; Pastan Ira
Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells.
European journal of haematology 2007;79(4):281-6.
2007: Hassan Raffit; Bullock Susie; Premkumar Ahalya; Kreitman Robert J; Kindler Hedy; Willingham Mark C; Pastan Ira
Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):5144-9.
2007: Du Xing; Ho Mitchell; Pastan Ira
New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(6):607-13.
2007: Sterman Daniel H; Recio Adri; Carroll Richard G; Gillespie Colin T; Haas Andrew; Vachani Anil; Kapoor Veena; Sun Jing; Hodinka Richard; Brown Jennifer L; Corbley Michael J; Parr Michael; Ho Mitchell; Pastan Ira; Machuzak Michael; Benedict William; Zhang Xin-qiao; Lord Elaina M; Litzky Leslie A; Heitjan Daniel F; June Carl H; Kaiser Larry R; Vonderheide Robert H; Albelda Steven M; Kanther Michelle
A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4456-66.
2007: Yokokawa Junko; Bera Tapan K; Palena Claudia; Cereda Vittore; Remondo Cinzia; Gulley James L; Arlen Philip M; Pastan Ira; Schlom Jeffrey; Tsang Kwong Y
Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).
International journal of cancer. Journal international du cancer 2007;121(3):595-605.
2007: Sampson John H; Raghavan Raghu; Brady Martin L; Provenzale James M; Herndon James E; Croteau David; Friedman Allan H; Reardon David A; Coleman R Edward; Wong Terence; Bigner Darell D; Pastan Ira; Rodríguez-Ponce María Inmaculada; Tanner Philipp; Puri Raj; Pedain Christoph
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
Neuro-oncology 2007;9(3):343-53.
2007: Filpula David; Yang Karen; Basu Amartya; Hassan Raffit; Xiang Laiman; Zhang Zhenfan; Wang Maoliang; Wang Qing-cheng; Ho Mitchell; Beers Richard; Zhao Hong; Peng Ping; Zhou John; Li Xiguang; Petti Gerald; Janjua Ahsen; Liu Jun; Wu Dechun; Yu Deshan; Zhang Zhihua; Longley Clifford; FitzGerald David; Kreitman Robert J; Pastan Ira
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Bioconjugate chemistry 2007;18(3):773-84.
2007: Ho Mitchell; Bera Tapan K; Willingham Mark C; Onda Masanori; Hassan Raffit; FitzGerald David; Pastan Ira
Mesothelin expression in human lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1571-5.
2007: Sampson John H; Raghavan Raghu; Provenzale James M; Croteau David; Reardon David A; Coleman R Edward; Rodríguez Ponce Inmaculada; Pastan Ira; Puri Raj K; Pedain Christoph
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
AJR. American journal of roentgenology 2007;188(3):703-9.
2007: Das Sudipto; Hahn Yoonsoo; Nagata Satoshi; Willingham Mark C; Bera Tapan K; Lee Byungkook; Pastan Ira
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.
Cancer research 2007;67(4):1594-601.
2007: Sampson John H; Brady Martin L; Petry Neil A; Croteau David; Friedman Allan H; Friedman Henry S; Wong Terence; Bigner Darell D; Pastan Ira; Puri Raj K; Pedain Christoph
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
Neurosurgery 2007;60(2 Suppl 1):ONS89-98; discussion ONS98-9.
2007: Ise T; Nagata S; Kreitman R J; Wilson W H; Wayne A S; Stetler-Stevenson M; Bishop M R; Scheinberg D A; Rassenti L; Kipps T J; Kyle R A; Jelinek D F; Pastan I
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(1):169-74.
2007: Hassan Raffit; Ebel Wolfgang; Routhier Eric L; Patel Rina; Kline J Bradford; Zhang Jingli; Chao Qimin; Jacob Sara; Turchin Howard; Gibbs Lester; Phillips Martin D; Mudali Shiyama; Iacobuzio-Donahue Christine; Jaffee Elizabeth M; Moreno Maria; Pastan Ira; Sass Philip M; Nicolaides Nicholas C; Grasso Luigi
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.
Cancer immunity : a journal of the Academy of Cancer Immunology 2007;7():20.
2007: Pastan Ira; Hassan Raffit; FitzGerald David J; Kreitman Robert J
Immunotoxin treatment of cancer.
Annual review of medicine 2007;58():221-37.
2006: Onda Masanori; Nagata Satoshi; FitzGerald David J; Beers Richard; Fisher Robert J; Vincent James J; Lee Byungkook; Nakamura Michihiro; Hwang Jaulang; Kreitman Robert J; Hassan Raffit; Pastan Ira
Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8822-34.
2006: Lee Yoomi; Ise Tomoko; Ha Duc; Saint Fleur Ashley; Hahn Yoonsoo; Liu Xiu-Fen; Nagata Satoshi; Lee Byungkook; Bera Tapan K; Pastan Ira
Evolution and expression of chimeric POTE-actin genes in the human genome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17885-90.
2006: Li Zhuqing; Mahesh Sankaranarayana P; Shen De Fen; Liu Baoying; Siu Willie O; Hwang Frank S; Wang Qing-Chen; Chan Chi-Chao; Pastan Ira; Nussenblatt Robert B
Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma.
Cancer research 2006;66(21):10586-93.
2006: Kennedy Paul E; Bera Tapan K; Wang Qing-Cheng; Gallo Maria; Wagner Wendeline; Lewis Mark G; Berger Edward A; Pastan Ira
Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.
Journal of leukocyte biology 2006;80(5):1175-82.
2006: Kreitman Robert J; Pastan Ira
Immunotoxins in the treatment of hematologic malignancies.
Current drug targets 2006;7(10):1301-11.
2006: Kreitman Robert J; Pastan Ira
Immunotoxins in the treatment of refractory hairy cell leukemia.
Hematology/oncology clinics of North America 2006;20(5):1137-51, viii.
2006: Ho Mitchell; Onda Masanori; Wang Qing-Cheng; Hassan Raffit; Pastan Ira; Lively Mark O
Mesothelin is shed from tumor cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(9):1751.
2006: Arons Evgeny; Sorbara Lynn; Raffeld Mark; Stetler-Stevenson Maryalice; Steinberg Seth M; Liewehr David J; Pastan Ira; Kreitman Robert J
Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy.
Cancer immunology, immunotherapy : CII 2006;55(9):1100-10.
2006: Zhang YuJian; Xiang Laiman; Hassan Raffit; Paik Chang H; Carrasquillo Jorge A; Jang Beom-Su; Le Nhat; Ho Mitchell; Pastan Ira
Synergistic antitumor activity of taxol and immunotoxin SS1P in tumor-bearing mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4695-701.
2006: Onda Masanori; Nagata Satoshi; Ho Mitchell; Bera Tapan K; Hassan Raffit; Alexander Richard H; Pastan Ira
Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4225-31.
2006: Pastan Ira; Hassan Raffit; Fitzgerald David J; Kreitman Robert J
Immunotoxin therapy of cancer.
Nature reviews. Cancer 2006;6(7):559-65.
2006: Ho Mitchell; Nagata Satoshi; Pastan Ira
Isolation of anti-CD22 Fv with high affinity by Fv display on human cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9637-42.
2006: Arons Evgeny; Margulies Inger; Sorbara Lynn; Raffeld Mark; Stetler-Stevenson Maryalice; Pastan Ira; Kreitman Robert J
Minimal residual disease in hairy cell leukemia patients assessed by clone-specific polymerase chain reaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2804-11.
2006: Steinbach Daniel; Schramm Alexander; Eggert Angelika; Onda Masanori; Dawczynski Kristin; Rump Andreas; Pastan Ira; Wittig Susann; Pfaffendorf Nadine; Voigt Astrid; Zintl Felix; Gruhn Bernd
Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2434-41.
2006: Egland Kristi A; Liu Xiu Fen; Squires Stephen; Nagata Satoshi; Man Yan-Gao; Bera Tapan K; Onda Masanori; Vincent James J; Strausberg Robert L; Lee Byungkook; Pastan Ira
High expression of a cytokeratin-associated protein in many cancers.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5929-34.
2006: Korherr Christian; Gille Hendrik; Schäfer Rolf; Koenig-Hoffmann Kerstin; Dixelius Johan; Egland Kristi A; Pastan Ira; Brinkmann Ulrich
Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4240-5.
2006: Attia Peter; Powell Daniel J; Maker Ajay V; Kreitman Robert J; Pastan Ira; Rosenberg Steven A
Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):208-14.
2006: Hahn Yoonsoo; Bera Tapan K; Pastan Ira H; Lee Byungkook
Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.
Gene 2006;366(2):238-45.
2006: Hassan Raffit; Remaley Alan T; Sampson Maureen L; Zhang Jingli; Cox Derrick D; Pingpank James; Alexander Richard; Willingham Mark; Pastan Ira; Onda Masanori
Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):447-53.
2006: Bera Tapan K; Saint Fleur Ashley; Lee Yoomi; Kydd Andre; Hahn Yoonsoo; Popescu Nicholas C; Zimonjic Drazen B; Lee Byungkook; Pastan Ira
POTE paralogs are induced and differentially expressed in many cancers.
Cancer research 2006;66(1):52-6.
2006: Gubbels Jennifer A A; Belisle Jennifer; Onda Masanori; Rancourt Claudine; Migneault Martine; Ho Mitchell; Bera Tapan K; Connor Joseph; Sathyanarayana Bangalore K; Lee Byungkook; Pastan Ira; Patankar Manish S
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.
Molecular cancer 2006;5(1):50.
2006: Kreitman Robert J; Pastan Ira
BL22 and lymphoid malignancies.
Best practice & research. Clinical haematology 2006;19(4):685-99.
2006: Ise Tomoko; Kreitman Robert J; Pastan Ira; Nagata Satoshi
Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(5):594-602.
2005: Yokokawa Junko; Palena Claudia; Arlen Philip; Hassan Raffit; Ho Mitchell; Pastan Ira; Schlom Jeffrey; Tsang Kwong Y
Identification of novel human CTL epitopes and their agonist epitopes of mesothelin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6342-51.
2005: Hassan Raffit; Kreitman Robert J; Pastan Ira; Willingham Mark C
Localization of mesothelin in epithelial ovarian cancer.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2005;13(3):243-7.
2005: Kreitman Robert J; Squires David R; Stetler-Stevenson Maryalice; Noel Pierre; FitzGerald David J P; Wilson Wyndham H; Pastan Ira
Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6719-29.
2005: Onda Masanori; Willingham Mark; Nagata Satoshi; Bera Tapan K; Beers Richard; Ho Mitchell; Hassan Raffit; Kreitman Robert J; Pastan Ira
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5840-6.
2005: Asano Takako; Niimura Fumio; Pastan Ira; Fogo Agnes B; Ichikawa Iekuni; Matsusaka Taiji
Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis.
Journal of the American Society of Nephrology : JASN 2005;16(8):2257-62.
2005: Sato Noriko; Hassan Raffit; Axworthy Donald B; Wong Karen J; Yu Sarah; Theodore Louis J; Lin Yukang; Park Luke; Brechbiel Martin W; Pastan Ira; Paik Chang H; Carrasquillo Jorge A
Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1201-9.
2005: Nagata Satoshi; Ise Tomoko; Onda Masanori; Nakamura Kazuyasu; Ho Mitchell; Raubitschek Andrew; Pastan Ira H
Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7946-51.
2005: Ho Mitchell; Hassan Raffit; Zhang Jingli; Wang Qing-Cheng; Onda Masanori; Bera Tapan; Pastan Ira
Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3814-20.
2005: Pastan Ira
An NIH career: from bedside to basic research and back.
The Journal of biological chemistry 2005;280(19):18553-7.
2005: Soler-García Angel A; Maitra Rangan; Kumar Vasantha; Ise Tomoko; Nagata Satoshi; Beers Richard; Bera Tapan K; Pastan Ira
The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein.
Reproduction (Cambridge, England) 2005;129(4):515-24.
2005: Matsusaka Taiji; Xin Jing; Niwa Suguri; Kobayashi Kazuto; Akatsuka Akira; Hashizume Hiroomi; Wang Qing-Cheng; Pastan Ira; Fogo Agnes B; Ichikawa Iekuni
Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.
Journal of the American Society of Nephrology : JASN 2005;16(4):1013-23.
2005: Bang Sookhee; Nagata Satoshi; Onda Masanori; Kreitman Robert J; Pastan Ira
HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(4):1545-50.
2005: Sampson John H; Reardon David A; Friedman Allan H; Friedman Henry S; Coleman R Edward; McLendon Roger E; Pastan Ira; Bigner Darell D
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
Neuro-oncology 2005;7(1):90-6.
2005: Ise Tomoko; Maeda Hiroshi; Santora Kenneth; Xiang Laiman; Kreitman Robert J; Pastan Ira; Nagata Satoshi
Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(1):87-96.
2005: Onda Masanori; Bruland Øyvind S; Pastan Ira
TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.
Clinical orthopaedics and related research 2005;(430):142-8.
2005: Ho Mitchell; Kreitman Robert J; Onda Masanori; Pastan Ira
In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin.
The Journal of biological chemistry 2005;280(1):607-17.
2004: Thomas Sufi M; Zeng Qing; Epperly Michael W; Gooding William E; Pastan Ira; Wang Qing Cheng; Greenberger Joel; Grandis Jennifer Rubin
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7079-87.
2004: Nagata Satoshi; Numata Yoshito; Onda Masanori; Ise Tomoko; Hahn Yoonsoo; Lee Byungkook; Pastan Ira
Rapid grouping of monoclonal antibodies based on their topographical epitopes by a label-free competitive immunoassay.
Journal of immunological methods 2004;292(1-2):141-55.
2004: Hahn Yoonsoo; Bera Tapan Kumar; Gehlhaus Kristen; Kirsch Ilan R; Pastan Ira H; Lee Byungkook
Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13257-61.
2004: Bera Tapan K; Huynh Nancy; Maeda Hiroshi; Sathyanarayana Bangalore K; Lee Byungkook; Pastan Ira
Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.
Gene 2004;337():45-53.
2004: Hassan Raffit; Bera Tapan; Pastan Ira
Mesothelin: a new target for immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):3937-42.
2004: Maeda Hiroshi; Nagata Satoshi; Wolfgang Curt D; Bratthauer Gary L; Bera Tapan K; Pastan Ira
The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria.
The Journal of biological chemistry 2004;279(23):24561-8.
2004: Yao Zhengsheng; Zhang Meili; Garmestani Kayhan; Axworthy Donald B; Mallett Robert W; Fritzberg Alan R; Theodore Lou J; Plascjak Paul S; Eckelman William C; Waldmann Thomas A; Pastan Ira; Paik Chang H; Brechbiel Martin W; Carrasquillo Jorge A
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3137-46.
2004: FitzGerald David J; Kreitman Robert; Wilson Wyndham; Squires David; Pastan Ira
Recombinant immunotoxins for treating cancer.
International journal of medical microbiology : IJMM 2004;293(7-8):577-82.
2004: Oh SangKon; Terabe Masaki; Pendleton C David; Bhattacharyya Anu; Bera Tapan K; Epel Malka; Reiter Yoram; Phillips John; Linehan W Marston; Kasten-Sportes Claude; Pastan Ira; Berzofsky Jay A
Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells.
Cancer research 2004;64(7):2610-8.
2004: Decker Thomas; Oelsner Madlene; Kreitman Robert J; Salvatore Giuliana; Wang Qing-cheng; Pastan Ira; Peschel Christian; Licht Thomas
Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins.
Blood 2004;103(7):2718-26.
2004: Bera Tapan K; Das Sudipto; Maeda Hiroshi; Beers Richard; Wolfgang Curt D; Kumar Vasantha; Hahn Yoonsoo; Lee Byungkook; Pastan Ira
NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3059-64.
2004: Onda Masanori; Wang Qing-cheng; Guo Hong-fen; Cheung Nai-Kong V; Pastan Ira
In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma.
Cancer research 2004;64(4):1419-24.
2004: Hassan Raffit; Williams-Gould Juanita; Watson Thelma; Pai-Scherf Lee; Pastan Ira
Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):16-8.
2004: Pastan Ira; Beers Richard; Bera Tapan K
Recombinant immunotoxins in the treatment of cancer.
Methods in molecular biology (Clifton, N.J.) 2004;248():503-18.
2003: Bera Tapan Kumar; Hahn Yoonsoo; Lee Byungkook; Pastan Ira H
TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates.
Biochemical and biophysical research communications 2003;312(4):1209-15.
2003: Gupta Amita; Onda Masanori; Pastan Ira; Adhya Sankar; Chaudhary Vijay K
High-density functional display of proteins on bacteriophage lambda.
Journal of molecular biology 2003;334(2):241-54.
2003: Sampson John H; Akabani Gamal; Archer Gary E; Bigner Darell D; Berger Mitchel S; Friedman Allan H; Friedman Henry S; Herndon James E; Kunwar Sandeep; Marcus Steve; McLendon Roger E; Paolino Alison; Penne Kara; Provenzale James; Quinn Jennifer; Reardon David A; Rich Jeremy; Stenzel Timothy; Tourt-Uhlig Sandra; Wikstrand Carol; Wong Terence; Williams Roger; Yuan Fan; Zalutsky Michael R; Pastan Ira
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.
Journal of neuro-oncology 2003;65(1):27-35.
2003: Sano Hiromi; Yasoshima Yasunobu; Matsushita Natsuki; Kaneko Takeshi; Kohno Kenji; Pastan Ira; Kobayashi Kazuto
Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9078-88.
2003: Nagata Satoshi; Salvatore Giuliana; Pastan Ira
DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins.
Journal of immunological methods 2003;280(1-2):59-72.
2003: Cheng Wing-Shing; Giandomenico Valeria; Pastan Ira; Essand Magnus
Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter.
Endocrinology 2003;144(8):3433-40.
2003: Soda Takeshi; Nakashima Ryo; Watanabe Dai; Nakajima Kazunori; Pastan Ira; Nakanishi Shigetada
Segregation and coactivation of developing neocortical layer 1 neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(15):6272-9.
2003: Olsson Pär; Motegi Akira; Bera Tapan K; Lee Byungkook; Pastan Ira
PRAC2: a new gene expressed in human prostate and prostate cancer.
The Prostate 2003;56(2):123-30.
2003: Kitabatake Yasuji; Hikida Takatoshi; Watanabe Dai; Pastan Ira; Nakanishi Shigetada
Impairment of reward-related learning by cholinergic cell ablation in the striatum.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7965-70.
2003: Lelong-Rebel Isabelle H; Rebel Gérard; Cardarelli Carol O; Pastan Ira; Gottesman Michael M
Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells.
Anticancer research 2003;23(3B):2363-75.
2003: Hikida Takatoshi; Kitabatake Yasuji; Pastan Ira; Nakanishi Shigetada
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6169-73.
2003: Pastan Ira
Immunotoxins containing Pseudomonas exotoxin A: a short history.
Cancer immunology, immunotherapy : CII 2003;52(5):338-41.
2003: Maitra Rangan; Grigoryev Dmitry N; Bera Tapan Kumar; Pastan Ira H; Lee Byungkook
Cloning, molecular characterization, and expression analysis of Copine 8.
Biochemical and biophysical research communications 2003;303(3):842-7.
2003: Kreitman Robert J; Pastan Ira
Immunobiological treatments of hairy-cell leukaemia.
Best practice & research. Clinical haematology 2003;16(1):117-33.
2003: Onda Masanori; Vincent James J; Lee Byungkook; Pastan Ira
Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules.
Bioconjugate chemistry 2003;14(2):480-7.
2003: Egland Kristi A; Vincent James J; Strausberg Robert; Lee Byungkook; Pastan Ira
Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1099-104.
2002: Hirano Tomoo; Watanabe Dai; Kawaguchi Shin-Ya; Pastan Ira; Nakanishi Shigetada
Roles of inhibitory interneurons in the cerebellar cortex.
Annals of the New York Academy of Sciences 2002;978():405-12.
2002: Bera Tapan K; Zimonjic Drazen B; Popescu Nicholas C; Sathyanarayana Bangalore K; Kumar Vasantha; Lee Byungkook; Pastan Ira
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16975-80.
2002: Kim Insook; Kobayashi Hisataka; Yoo Tae M; Kim Meyong-kon; Le Nhat; Han Eui-sik; Wang Q C; Pastan Ira; Carrasquillo Jorge A; Paik Chang H
Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.
Nuclear medicine and biology 2002;29(8):795-801.
2002: Hassan Raffit; Lerner Megan R; Benbrook Doris; Lightfoot Stan A; Brackett Daniel J; Wang Qing-Cheng; Pastan Ira
Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3520-6.
2002: Yao Zhengsheng; Zhang Meili; Axworthy Donald B; Wong Karen J; Garmestani Kayhan; Park Luke; Park Chang W; Mallett Robert W; Theodore Louis J; Yau Eric K; Waldmann Thomas A; Brechbiel Martin W; Paik Chang H; Pastan Ira; Carrasquillo Jorge A
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Cancer research 2002;62(20):5755-60.
2002: McHugh Louise; Hu Stella; Lee B K; Santora Kenneth; Kennedy Paul E; Berger Edward A; Pastan Ira; Hamer Dean H
Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis.
The Journal of biological chemistry 2002;277(37):34383-90.
2002: Pastan Ira; Kreitman Robert J
Immunotoxins in cancer therapy.
Current opinion in investigational drugs (London, England : 2000) 2002;3(7):1089-91.
2002: Nagata Satoshi; Onda Masanori; Numata Yoshito; Santora Kenneth; Beers Richard; Kreitman Robert J; Pastan Ira
Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2345-55.
2002: Fan Dominic; Yano Seiji; Shinohara Hisashi; Solorzano Carmen; Van Arsdall Melissa; Bucana Corazon D; Pathak Sen; Kruzel Ewa; Herbst Roy S; Onn Amir; Roach Jennifer S; Onda Masanori; Wang Qing-cheng; Pastan Ira; Fidler Isaiah J
Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.
Molecular cancer therapeutics 2002;1(8):595-600.
2002: Salvatore Giuliana; Nagata Satoshi; Billaud Marc; Santoro Massimo; Vecchio Giancarlo; Pastan Ira
Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase.
Biochemical and biophysical research communications 2002;294(4):813-7.
2002: Egland Kristi A; Kumar Vasantha; Duray Paul; Pastan Ira
Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers.
Molecular cancer therapeutics 2002;1(7):441-50.
2002: Bera Tapan K; Iavarone Carlo; Kumar Vasantha; Lee Sanghyuk; Lee Byungkook; Pastan Ira
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6997-7002.
2002: Hazama Masaaki; Watanabe Dai; Suzuki Misao; Mizoguchi Akira; Pastan Ira; Nakanishi Shigetada
Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice.
Brain research. Molecular brain research 2002;100(1-2):53-66.
2002: Salvatore Giuliana; Beers Richard; Margulies Inger; Kreitman Robert J; Pastan Ira
Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):995-1002.
2002: Iavarone Carlo; Wolfgang Curt; Kumar Vasantha; Duray Paul; Willingham Mark; Pastan Ira; Bera Tapan K
PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.
Molecular cancer therapeutics 2002;1(5):329-35.
2002: Bera Tapan K; Maitra Rangan; Iavarone Carlo; Salvatore Giuliana; Kumar Vasantha; Vincent James J; Sathyanarayana B K; Duray Paul; Lee B K; Pastan Ira
PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3058-63.
2002: Decker Thomas; Hipp Susanne; Kreitman Robert J; Pastan Ira; Peschel Christian; Licht Thomas
Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides.
Blood 2002;99(4):1320-6.
2002: Shinohara Hisashi; Morita Shinsho; Kawai Masaru; Miyamoto Akiko; Sonoda Toyooki; Pastan Ira; Tanigawa Nobuhiko
Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin.
The Journal of surgical research 2002;102(2):169-77.
2002: Joshi B H; Leland P; Silber J; Kreitman R J; Pastan I; Berger M; Puri R K
IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein.
British journal of cancer 2002;86(2):285-91.
2001: Bera T K; Williams-Gould J; Beers R; Chowdhury P; Pastan I
Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer.
Molecular cancer therapeutics 2001;1(2):79-84.
2001: Park J H; Kwon H W; Chung H K; Kim I H; Ahn K; Choi E J; Pastan I; Choe M
A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains.
Molecules and cells 2001;12(3):398-402.
2001: Wolfgang C D; Essand M; Lee B; Pastan I
T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin.
Cancer research 2001;61(22):8122-6.
2001: Hikida T; Kaneko S; Isobe T; Kitabatake Y; Watanabe D; Pastan I; Nakanishi S
Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13351-4.
2001: Bera T K; Bera J; Brinkmann U; Tessarollo L; Pastan I
Cse1l is essential for early embryonic growth and development.
Molecular and cellular biology 2001;21(20):7020-4.
2001: Kobayashi T; Kida Y; Kaneko T; Pastan I; Kobayashi K
Efficient ablation by immunotoxin-mediated cell targeting of the cell types that express human interleukin-2 receptor depending on the internal ribosome entry site.
The journal of gene medicine 2001;3(5):505-10.
2001: Olsson P; Bera T K; Essand M; Kumar V; Duray P; Vincent J; Lee B; Pastan I
GDEP, a new gene differentially expressed in normal prostate and prostate cancer.
The Prostate 2001;48(4):231-41.
2001: Bera T K; Lee S; Salvatore G; Lee B; Pastan I
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.
Molecular medicine (Cambridge, Mass.) 2001;7(8):509-16.
2001: Kreitman R J; Wilson W H; Bergeron K; Raggio M; Stetler-Stevenson M; FitzGerald D J; Pastan I
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia.
The New England journal of medicine 2001;345(4):241-7.
2001: Onda M; Nagata S; Tsutsumi Y; Vincent J J; Wang Q; Kreitman R J; Lee B; Pastan I
Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
Cancer research 2001;61(13):5070-7.
2001: Yoshida K; Watanabe D; Ishikane H; Tachibana M; Pastan I; Nakanishi S
A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.
Neuron 2001;30(3):771-80.
2001: Rozemuller H; Chowdhury P S; Pastan I; Kreitman R J
Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 2001;92(6):861-70.
2001: Garmestani K; Yao Z; Zhang M; Wong K; Park C W; Pastan I; Carrasquillo J A; Brechbiel M W
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.
Nuclear medicine and biology 2001;28(4):409-18.
2001: Lee C G; Vieira W D; Pastan I; Gottesman M M
An episomally maintained MDR1 gene for gene therapy.
Human gene therapy 2001;12(8):945-53.
2001: Liu X F; Olsson P; Wolfgang C D; Bera T K; Duray P; Lee B; Pastan I
PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon.
The Prostate 2001;47(2):125-31.
2001: Wellmann A; Flemming P; Behrens P; Wuppermann K; Lang H; Oldhafer K; Pastan I; Brinkmann U
High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression.
International journal of molecular medicine 2001;7(5):489-94.
2001: Moll J R; Ruvinov S B; Pastan I; Vinson C
Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10(-15) M.
Protein science : a publication of the Protein Society 2001;10(3):649-55.
2001: Onda M; Olafsen T; Tsutsumi Y; Bruland O S; Pastan I
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2001;24(2):144-50.
2001: Yerushalmi N; Keppler-Hafkemeyer A; Vasmatzis G; Liu X F; Olsson P; Bera T K; Duray P; Lee B; Pastan I
ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues.
Gene 2001;265(1-2):55-60.
2001: Chowdhury P S; Gallo M; Pastan I
Generation of high titer antisera in rabbits by DNA immunization.
Journal of immunological methods 2001;249(1-2):147-54.
2000: Onda M; Willingham M; Wang Q C; Kreitman R J; Tsutsumi Y; Nagata S; Pastan I
Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7150-6.
2000: Kuan C T; Wikstrand C J; Archer G; Beers R; Pastan I; Zalutsky M R; Bigner D D
Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv.
International journal of cancer. Journal international du cancer 2000;88(6):962-9.
2000: Shinohara H; Fan D; Ozawa S; Yano S; Van Arsdell M; Viner J L; Beers R; Pastan I; Fidler I J
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
International journal of oncology 2000;17(4):643-51.
2000: Liu X F; Helman L J; Yeung C; Bera T K; Lee B; Pastan I
XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.
Cancer research 2000;60(17):4752-5.
2000: Wolfgang C D; Essand M; Vincent J J; Lee B; Pastan I
TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9437-42.
2000: Hassan R; Viner J L; Wang Q C; Margulies I; Kreitman R J; Pastan I
Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):473-9.
2000: Kaneko S; Hikida T; Watanabe D; Ichinose H; Nagatsu T; Kreitman R J; Pastan I; Nakanishi S
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Science (New York, N.Y.) 2000;289(5479):633-7.
2000: Beers R; Chowdhury P; Bigner D; Pastan I
Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2835-43.
2000: Tsutsumi Y; Onda M; Nagata S; Lee B; Kreitman R J; Pastan I
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8548-53.
2000: Keppler-Hafkemeyer A; Kreitman R J; Pastan I
Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies.
International journal of cancer. Journal international du cancer 2000;87(1):86-94.
2000: Rand R W; Kreitman R J; Patronas N; Varricchio F; Pastan I; Puri R K
Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2157-65.
2000: Booth C L; Pulaski L; Gottesman M M; Pastan I
Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.
Biochemistry 2000;39(18):5518-26.
2000: Pai-Scherf L H; Carrasquillo J A; Paik C; Gansow O; Whatley M; Pearson D; Webber K; Hamilton M; Allegra C; Brechbiel M; Willingham M C; Pastan I
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1720-30.
2000: Kreitman R J; Margulies I; Stetler-Stevenson M; Wang Q C; FitzGerald D J; Pastan I
Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1476-87.
2000: Kobayashi H; Kao C H; Kreitman R J; Le N; Kim M K; Brechbiel M W; Paik C H; Pastan I; Carrasquillo J A
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):755-62.
2000: Kreitman R J; Wilson W H; White J D; Stetler-Stevenson M; Jaffe E S; Giardina S; Waldmann T A; Pastan I
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(8):1622-36.
2000: Bera T K; Pastan I
Mesothelin is not required for normal mouse development or reproduction.
Molecular and cellular biology 2000;20(8):2902-6.
2000: Shen D W; Goldenberg S; Pastan I; Gottesman M M
Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake.
Journal of cellular physiology 2000;183(1):108-16.
2000: Leland P; Taguchi J; Husain S R; Kreitman R J; Pastan I; Puri R K
Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo.
Molecular medicine (Cambridge, Mass.) 2000;6(3):165-78.
2000: Hafkemeyer P; Licht T; Pastan I; Gottesman M M
Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers.
Human gene therapy 2000;11(4):555-65.
2000: Goldstein H; Pettoello-Mantovani M; Bera T K; Pastan I H; Berger E A
Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice.
The Journal of infectious diseases 2000;181(3):921-6.
2000: Lee C G; Ramachandra M; Jeang K T; Martin M A; Pastan I; Gottesman M M
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(3):516-22.
2000: Mariano A; Di Carlo A; Pastan I; Macchia V
Analysis of glycoproteins in cancers and normal tissues reactive with monoclonal antibodies B3 and B1.
International journal of oncology 2000;16(3):549-53.
2000: Licht T; Goldenberg S K; Vieira W D; Gottesman M M; Pastan I
Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice.
Gene therapy 2000;7(4):348-58.
2000: Yerushalmi N; Brinkmann U; Brinkmann E; Pai L; Pastan I
Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes.
Cancer gene therapy 2000;7(1):91-6.
1999: Chowdhury P S; Pastan I
Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations.
Journal of immunological methods 1999;231(1-2):83-91.
1999: Kobayashi H; Tagaya Y; Han E S; Kim I S; Le N; Paik C H; Pastan I; Nelson D L; Waldmann T A; Carrasquillo J A
Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.
Cytokine 1999;11(12):1065-75.
1999: Onda M; Kreitman R J; Vasmatzis G; Lee B; Pastan I
Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6072-7.
1999: Adobati E; Zacchetti A; Perico M E; Cremonesi F; Rasi G; Vallebona P S; Hagenaars M; Kuppen P J; Pastan I; Panza L; Russo G; Colnaghi M I; Canevari S
Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: implication for the development of human-derived cancer vaccines.
The Histochemical journal 1999;31(11):729-37.
1999: Kreitman R J; Wilson W H; Robbins D; Margulies I; Stetler-Stevenson M; Waldmann T A; Pastan I
Responses in refractory hairy cell leukemia to a recombinant immunotoxin.
Blood 1999;94(10):3340-8.
1999: Liu X F; Essand M; Vasmatzis G; Lee B; Pastan I
Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.
Biochemical and biophysical research communications 1999;264(3):833-9.
1999: Zhou Y; Gottesman M M; Pastan I
Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2).
Molecular pharmacology 1999;56(5):997-1004.
1999: Hrycyna C A; Ramachandra M; Germann U A; Cheng P W; Pastan I; Gottesman M M
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Biochemistry 1999;38(42):13887-99.
1999: Archer G E; Sampson J H; Lorimer I A; McLendon R E; Kuan C T; Friedman A H; Friedman H S; Pastan I H; Bigner D D
Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2646-52.
1999: Pai-Scherf L H; Villa J; Pearson D; Watson T; Liu E; Willingham M C; Pastan I
Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2311-5.
1999: Licht T; Aran J M; Goldenberg S K; Vieira W D; Gottesman M M; Pastan I
Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein.
Human gene therapy 1999;10(13):2173-85.
1999: Bera T K; Viner J; Brinkmann E; Pastan I
Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2.
Cancer research 1999;59(16):4018-22.
1999: Kobayashi H; Sun B F; Yoo T M; Le N; Kim M K; Paik C H; Pastan I; Waldmann T A; Carrasquillo J A
Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(8):1381-91.
1999: Essand M; Vasmatzis G; Brinkmann U; Duray P; Lee B; Pastan I
High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9287-92.
1999: Cowan K H; Moscow J A; Huang H; Zujewski J A; O'Shaughnessy J; Sorrentino B; Hines K; Carter C; Schneider E; Cusack G; Noone M; Dunbar C; Steinberg S; Wilson W; Goldspiel B; Read E J; Leitman S F; McDonagh K; Chow C; Abati A; Chiang Y; Chang Y N; Gottesman M M; Pastan I; Nienhuis A
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1619-28.
1999: Husain S R; Kreitman R J; Pastan I; Puri R K
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.
Nature medicine 1999;5(7):817-22.
1999: Moscow J A; Huang H; Carter C; Hines K; Zujewski J; Cusack G; Chow C; Venzon D; Sorrentino B; Chiang Y; Goldspiel B; Leitman S; Read E J; Abati A; Gottesman M M; Pastan I; Sellers S; Dunbar C; Cowan K H
Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.
Blood 1999;94(1):52-61.
1999: Zhou Y; Gottesman M M; Pastan I
The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2.
Archives of biochemistry and biophysics 1999;367(1):74-80.
1999: Kuan C T; Reist C J; Foulon C F; Lorimer I A; Archer G; Pegram C N; Pastan I; Zalutsky M R; Bigner D D
125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1539-49.
1999: Chowdhury P S; Pastan I
Improving antibody affinity by mimicking somatic hypermutation in vitro.
Nature biotechnology 1999;17(6):568-72.
1999: Dey S; Hafkemeyer P; Pastan I; Gottesman M M
A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.
Biochemistry 1999;38(20):6630-9.
1999: Kim I S; Yoo T M; Kobayashi H; Kim M K; Le N; Wang Q C; Pastan I; Carrasquillo J A; Paik C H
Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.
Bioconjugate chemistry 1999;10(3):447-53.
1999: Brinkmann U; Brinkmann E; Bera T K; Wellmann A; Pastan I
Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.
Genomics 1999;58(1):41-9.
1999: Hafkemeyer P; Brinkmann U; Gottesman M M; Pastan I
Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo.
Human gene therapy 1999;10(6):923-34.
1999: Brinkmann U; Vasmatzis G; Lee B; Pastan I
Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.
Cancer research 1999;59(7):1445-8.
1999: Lou Q; Pastan I
A Lewis(y) epitope mimicking peptide induces anti-Lewis(y) immune responses in rabbits and mice.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):252-60.
1999: Jwang B; Yerushalmi N; Kreitman R J; Engberg J; Pastan I
An scFv phage clone that binds to human beta2-microglobulin.
Immunotechnology : an international journal of immunological engineering 1999;4(3-4):231-6.
1999: Kreitman R J; Wang Q C; FitzGerald D J; Pastan I
Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys.
International journal of cancer. Journal international du cancer 1999;81(1):148-55.
1999: Friedrich K; Wietek S; Lischke A; Wellbrock C; Kreitman R J; Pastan I; Sebald W
A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors.
Analytical biochemistry 1999;268(2):179-86.
1999: Hassan R; Wu C; Brechbiel M W; Margulies I; Kreitman R J; Pastan I
111Indium-labeled monoclonal antibody K1: biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin.
International journal of cancer. Journal international du cancer 1999;80(4):559-63.
1999: Zhou Y; Gottesman M M; Pastan I
Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase.
Molecular and cellular biology 1999;19(2):1450-9.
1999: Harris D T; Sakiestewa D; Lyons C; Kreitman R J; Pastan I
Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor.
Bone marrow transplantation 1999;23(2):137-44.
1999: Aran J M; Pastan I; Gottesman M M
Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy.
Advances in pharmacology (San Diego, Calif.) 1999;46():1-42.
1999: Ambudkar S V; Dey S; Hrycyna C A; Ramachandra M; Pastan I; Gottesman M M
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annual review of pharmacology and toxicology 1999;39():361-98.
1998: Reiter Y; Pastan I
Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis.
Trends in biotechnology 1998;16(12):513-20.
1998: Keppler-Hafkemeyer A; Brinkmann U; Pastan I
Role of caspases in immunotoxin-induced apoptosis of cancer cells.
Biochemistry 1998;37(48):16934-42.
1998: Hafkemeyer P; Dey S; Ambudkar S V; Hrycyna C A; Pastan I; Gottesman M M
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.
Biochemistry 1998;37(46):16400-9.
1998: Bera T K; Pastan I
Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability.
Bioconjugate chemistry 1998;9(6):736-43.
1998: Russ G; Ramachandra M; Hrycyna C A; Gottesman M M; Pastan I; Bennink J R; Yewdell J W
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer research 1998;58(20):4688-93.
1998: Watanabe D; Inokawa H; Hashimoto K; Suzuki N; Kano M; Shigemoto R; Hirano T; Toyama K; Kaneko S; Yokoi M; Moriyoshi K; Suzuki M; Kobayashi K; Nagatsu T; Kreitman R J; Pastan I; Nakanishi S
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Cell 1998;95(1):17-27.
1998: Shoshani T; Zhang S; Dey S; Pastan I; Gottesman M M
Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.
Molecular pharmacology 1998;54(4):623-30.
1998: Scherf U; Kalab P; Dasso M; Pastan I; Brinkmann U
The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS.
Biochemical and biophysical research communications 1998;250(3):623-8.
1998: Hrycyna C A; Airan L E; Germann U A; Ambudkar S V; Pastan I; Gottesman M M
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Biochemistry 1998;37(39):13660-73.
1998: Berger E A; Moss B; Pastan I
Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11511-3.
1998: Brinkmann U; Vasmatzis G; Lee B; Yerushalmi N; Essand M; Pastan I
PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10757-62.
1998: Chowdhury P S; Vasmatzis G; Beers R; Lee B; Pastan I
Improved stability and yield of a Fv-toxin fusion protein by computer design and protein engineering of the Fv.
Journal of molecular biology 1998;281(5):917-28.
1998: Husain S R; Behari N; Kreitman R J; Pastan I; Puri R K
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
Cancer research 1998;58(16):3649-53.
1998: Seetharam S; Nodzenski E; Beckett M A; Heimann R; Cha A; Margulies I; Pastan I; Kufe D W; Weichselbaum R R
Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein.
Cancer research 1998;58(15):3215-20.
1998: Bera T K; Onda M; Brinkmann U; Pastan I
A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
Journal of molecular biology 1998;281(3):475-83.
1998: Culig Z; Hittmair A; Hobisch A; Bartsch G; Klocker H; Pai L H; Pastan I
Expression of Lewis carbohydrate antigens in metastatic lesions from human prostatic carcinoma.
The Prostate 1998;36(3):162-7.
1998: Aran J M; Gottesman M M; Pastan I
Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein.
Cancer gene therapy 1998;5(4):195-206.
1998: Hrycyna C A; Ramachandra M; Ambudkar S V; Ko Y H; Pedersen P L; Pastan I; Gottesman M M
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
The Journal of biological chemistry 1998;273(27):16631-4.
1998: Essand M; Pastan I
Anti-prostate immunotoxins: cytotoxicity of E4 antibody-Pseudomonas exotoxin constructs.
International journal of cancer. Journal international du cancer 1998;77(1):123-7.
1998: Bera T K; Kennedy P E; Berger E A; Barbas C F; Pastan I
Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein.
Molecular medicine (Cambridge, Mass.) 1998;4(6):384-91.
1998: Carrasquillo J A; Lang L; Whatley M; Herscovitch P; Wang Q C; Pastan I; Eckelman W C
Aminosyn II effectively blocks renal uptake of 18F-labeled anti-tac disulfide-stabilized Fv.
Cancer research 1998;58(12):2612-7.
1998: Kleiman S E; Pastan I; Puck J M; Gottesman M M
Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency.
Gene therapy 1998;5(5):671-6.
1998: Kobayashi H; Han E S; Kim I S; Le N; Rajagopal V; Kreitman R J; Pastan I; Paik C H; Carrasquillo J A
Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment.
Nuclear medicine and biology 1998;25(4):387-93.
1998: Almog O; Benhar I; Vasmatzis G; Tordova M; Lee B; Pastan I; Gilliland G L
Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond.
Proteins 1998;31(2):128-38.
1998: Kobayashi H; Wu C; Yoo T M; Sun B F; Drumm D; Pastan I; Paik C H; Gansow O A; Carrasquillo J A; Brechbiel M W
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(5):829-36.
1998: Kobayashi H; Sun B F; Han E S; Kim M K; Le N; Wang Q C; Nelson D L; Pastan I; Waldmann T A; Paik C H; Carrasquillo J A
Epitope blocking: positive and negative effects on the biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment of two antibodies against different epitopes of the circulating antigen.
Japanese journal of cancer research : Gann 1998;89(4):436-44.
1998: Yang D; Kuan C T; Payne J; Kihara A; Murray A; Wang L M; Alimandi M; Pierce J H; Pastan I; Lippman M E
Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):993-1004.
1998: Ramachandra M; Ambudkar S V; Chen D; Hrycyna C A; Dey S; Gottesman M M; Pastan I
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.
Biochemistry 1998;37(14):5010-9.
1998: Lee C G; Gottesman M M; Cardarelli C O; Ramachandra M; Jeang K T; Ambudkar S V; Pastan I; Dey S
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
Biochemistry 1998;37(11):3594-601.
1998: Kreitman R J; Pastan I
Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses.
Cancer research 1998;58(5):968-75.
1998: Zhou Y; Aran J; Gottesman M M; Pastan I
Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector.
Human gene therapy 1998;9(3):287-93.
1998: Sawada H; Nishii K; Suzuki T; Hasegawa K; Hata T; Nagatsu I; Kreitman R J; Pastan I; Nagatsu T; Kobayashi K
Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system.
Journal of neuroscience research 1998;51(2):162-73.
1998: Shen D; Pastan I; Gottesman M M
Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.
Cancer research 1998;58(2):268-75.
1998: Chowdhury P S; Viner J L; Beers R; Pastan I
Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):669-74.
1998: Vasmatzis G; Essand M; Brinkmann U; Lee B; Pastan I
Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):300-4.
1998: Lee C G; Pastan I; Gottesman M M
Retroviral transfer of human MDR1 gene into human T lymphocytes.
Methods in enzymology 1998;292():557-72.
1998: Licht T; Gottesman M M; Pastan I
Retroviral transfer of multidrug transporter to murine hematopoietic stem cells.
Methods in enzymology 1998;292():546-57.
1998: Sugimoto Y; Gottesman M M; Pastan I; Tsuruo T
Construction of MDR1 vectors for gene therapy.
Methods in enzymology 1998;292():523-37.
1998: Zhang S; Sugimoto Y; Shoshani T; Pastan I; Gottesman M M
pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein.
Methods in enzymology 1998;292():474-80.
1998: Hrycyna C A; Ramachandra M; Pastan I; Gottesman M M
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Methods in enzymology 1998;292():456-73.
1998: Ramachandra M; Gottesman M M; Pastan I
Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells.
Methods in enzymology 1998;292():441-55.
1998: Dey S; Ramachandra M; Pastan I; Gottesman M M; Ambudkar S V
Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.
Methods in enzymology 1998;292():318-28.
1998: Gottesman M M; Cardarelli C; Goldenberg S; Licht T; Pastan I
Selection and maintenance of multidrug-resistant cells.
Methods in enzymology 1998;292():248-58.
1998: Pai L H; Pastan I
Clinical trials with Pseudomonas exotoxin immunotoxins.
Current topics in microbiology and immunology 1998;234():83-96.
1998: FitzGerald D; Pastan I; Robertus J
Clinical applications of immunotoxins. Introduction.
Current topics in microbiology and immunology 1998;234():1-11.
1997: Rajagopal V; Pastan I; Kreitman R J
A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs.
Protein engineering 1997;10(12):1453-9.
1997: Pastan I
Targeted therapy of cancer with recombinant immunotoxins.
Biochimica et biophysica acta 1997;1333(2):C1-6.
1997: Wu C; Kobayashi H; Sun B; Yoo T M; Paik C H; Gansow O A; Carrasquillo J A; Pastan I; Brechbiel M W
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorganic & medicinal chemistry 1997;5(10):1925-34.
1997: Lee C G; Jeang K T; Martin M A; Pastan I; Gottesman M M
Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene.
Antisense & nucleic acid drug development 1997;7(5):511-22.
1997: Dey S; Ramachandra M; Pastan I; Gottesman M M; Ambudkar S V
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10594-9.
1997: Rozemuller H; Rombouts E J; Touw I P; FitzGerald D J; Kreitman R J; Pastan I; Hagenbeek A; Martens A C
Sensitivity of human acute myeloid leukaemia to diphtheria toxin-GM-CSF fusion protein.
British journal of haematology 1997;98(4):952-9.
1997: Mansfield E; Amlot P; Pastan I; FitzGerald D J
Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors.
Blood 1997;90(5):2020-6.
1997: Maini A; Hillman G; Haas G P; Wang C Y; Montecillo E; Hamzavi F; Pontes J E; Leland P; Pastan I; Debinski W; Puri R K
Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin.
The Journal of urology 1997;158(3 Pt 1):948-53.
1997: Ogryzko V V; Brinkmann E; Howard B H; Pastan I; Brinkmann U
Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells.
Biochemistry 1997;36(31):9493-500.
1997: Funatomi H; Itakura J; Ishiwata T; Pastan I; Thompson S A; Johnson G R; Korc M
Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.
International journal of cancer. Journal international du cancer 1997;72(3):512-7.
1997: Kreitman R J; Pastan I
Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells.
Blood 1997;90(1):252-9.
1997: Roscoe D M; Pai L H; Pastan I
Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins.
European journal of immunology 1997;27(6):1459-68.
1997: Lang L; Jagoda E; Wu C; Brechbiel M W; Gansow O A; Pastan I; Paik C H; Carrasquillo J A; Eckelman W C
Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):53-61.
1997: Husain S R; Gill P; Kreitman R J; Pastan I; Puri R K
Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
Molecular medicine (Cambridge, Mass.) 1997;3(5):327-38.
1997: Mansfield E; Chiron M F; Amlot P; Pastan I; FitzGerald D J
Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells.
Biochemical Society transactions 1997;25(2):709-14.
1997: Brinkmann U; Webber K; Di Carlo A; Beers R; Chowdhury P; Chang K; Chaudhary V; Gallo M; Pastan I
Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers.
International journal of cancer. Journal international du cancer 1997;71(4):638-44.
1997: Wu C; Jagoda E; Brechbiel M; Webber K O; Pastan I; Gansow O; Eckelman W C
Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.
Bioconjugate chemistry 1997;8(3):365-9.
1997: Kobayashi H; Yoo T M; Drumm D; Kim M K; Sun B F; Le N; Webber K O; Pastan I; Waldmann T A; Paik C H; Carrasquillo J A
Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
Cancer research 1997;57(10):1955-61.
1997: Brinkmann U; Di Carlo A; Vasmatzis G; Kurochkina N; Beers R; Lee B; Pastan I
Stabilization of a recombinant Fv fragment by base-loop interconnection and V(H)-V(L) permutation.
Journal of molecular biology 1997;268(1):107-17.
1997: Reiter Y; Di Carlo A; Fugger L; Engberg J; Pastan I
Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4631-6.
1997: Ohshima T; Murray G J; Swaim W D; Longenecker G; Quirk J M; Cardarelli C O; Sugimoto Y; Pastan I; Gottesman M M; Brady R O; Kulkarni A B
alpha-Galactosidase A deficient mice: a model of Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2540-4.
1997: Husain S R; Obiri N I; Gill P; Zheng T; Pastan I; Debinski W; Puri R K
Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):151-6.
1997: Yoo T M; Chang H K; Choi C W; Webber K O; Le N; Kim I S; Eckelman W C; Pastan I; Carrasquillo J A; Paik C H
Technetium-99m labeling and biodistribution of anti-TAC disulfide-stabilized Fv fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(2):294-300.
1997: Chowdhury P S; Chang K; Pastan I
Isolation of anti-mesothelin antibodies from a phage display library.
Molecular immunology 1997;34(1):9-20.
1997: Sugimoto Y; Sato S; Tsukahara S; Suzuki M; Okochi E; Gottesman M M; Pastan I; Tsuruo T
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Cancer gene therapy 1997;4(1):51-8.
1997: Wellmann A; Krenacs L; Fest T; Scherf U; Pastan I; Raffeld M; Brinkmann U
Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms.
The American journal of pathology 1997;150(1):25-30.
1997: Brinkmann U; Mansfield E; Pastan I
Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins.
Apoptosis : an international journal on programmed cell death 1997;2(2):192-8.
1997: Licht T; Herrmann F; Gottesman M M; Pastan I
In vivo drug-selectable genes: a new concept in gene therapy.
Stem cells (Dayton, Ohio) 1997;15(2):104-11.
1996: Puri R K; Hoon D S; Leland P; Snoy P; Rand R W; Pastan I; Kreitman R J
Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.
Cancer research 1996;56(24):5631-7.
1996: Lorimer I A; Keppler-Hafkemeyer A; Beers R A; Pegram C N; Bigner D D; Pastan I
Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14815-20.
1996: Aran J M; Licht T; Gottesman M M; Pastan I
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
Human gene therapy 1996;7(17):2165-75.
1996: Rozemuller H; Rombouts W J; Touw I P; FitzGerald D J; Kreitman R J; Pastan I; Hagenbeek A; Martens A C
Treatment of acute myelocytic leukemia with interleukin-6 Pseudomonas exotoxin fusion protein in a rat leukemia model.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(11):1796-803.
1996: Reiter Y; Brinkmann U; Lee B; Pastan I
Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.
Nature biotechnology 1996;14(10):1239-45.
1996: Gottesman M M; Pastan I; Ambudkar S V
P-glycoprotein and multidrug resistance.
Current opinion in genetics & development 1996;6(5):610-7.
1996: Ramachandra M; Ambudkar S V; Gottesman M M; Pastan I; Hrycyna C A
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Molecular biology of the cell 1996;7(10):1485-98.
1996: Scherf U; Benhar I; Webber K O; Pastan I; Brinkmann U
Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1523-31.
1996: Mansfield E; Pastan I; FitzGerald D J
Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies.
Bioconjugate chemistry 1996;7(5):557-63.
1996: Kobayashi K; Ohye T; Pastan I; Nagatsu T
A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting.
Nucleic acids research 1996;24(18):3653-5.
1996: Kobayashi H; Yoo T M; Kim I S; Kim M K; Le N; Webber K O; Pastan I; Paik C H; Eckelman W C; Carrasquillo J A
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer research 1996;56(16):3788-95.
1996: Baudard M; Flotte T R; Aran J M; Thierry A R; Pastan I; Pang M G; Kearns W G; Gottesman M M
Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes.
Human gene therapy 1996;7(11):1309-22.
1996: Baldwin R L; Kobrin M S; Tran T; Pastan I; Korc M
Cytotoxic effects of TGF-alpha-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells.
Pancreas 1996;13(1):16-21.
1996: Li M; Dyda F; Benhar I; Pastan I; Davies D R
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6902-6.
1996: Reiter Y; Wright A F; Tonge D W; Pastan I
Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
International journal of cancer. Journal international du cancer 1996;67(1):113-23.
1996: Johnson S W; Shen D; Pastan I; Gottesman M M; Hamilton T C
Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines.
Experimental cell research 1996;226(1):133-9.
1996: Puri R K; Leland P; Obiri N I; Husain S R; Mule J; Pastan I; Kreitman R J
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity.
Cellular immunology 1996;171(1):80-6.
1996: Aksentijevich I; Cardarelli C O; Pastan I; Gottesman M M
Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):973-80.
1996: Aksentijevich I; Pastan I; Lunardi-Iskandar Y; Gallo R C; Gottesman M M; Thierry A R
In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells.
Human gene therapy 1996;7(9):1111-22.
1996: Baudard M; Pastan I; Gottesman M M
Transfer of the MDR1 gene into haematopoietic cells.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):1019-23.
1996: Mavroudis D A; Jiang Y Z; Hensel N; Lewalle P; Couriel D; Kreitman R J; Pastan I; Barrett A J
Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.
Bone marrow transplantation 1996;17(5):793-9.
1996: Puri R K; Leland P; Obiri N I; Husain S R; Kreitman R J; Haas G P; Pastan I; Debinski W
Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR).
Blood 1996;87(10):4333-9.
1996: Brinkmann U; Brinkmann E; Gallo M; Scherf U; Pastan I
Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis.
Biochemistry 1996;35(21):6891-9.
1996: King C R; Fischer P H; Rando R F; Pastan I
The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein.
Seminars in cancer biology 1996;7(2):79-86.
1996: Licht T; Pastan I; Gottesman M M; Herrmann F
The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders.
Annals of hematology 1996;72(4):184-93.
1996: Scherf U; Pastan I; Willingham M C; Brinkmann U
The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2670-4.
1996: Aran J M; Germann U A; Gottesman M M; Pastan I
Construction and characterization of a selectable multidrug resistance-glucocerebrosidase fusion gene.
Cytokines and molecular therapy 1996;2(1):47-57.
1996: Brinkmann U; Gallo M; Polymeropoulos M H; Pastan I
The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines.
Genome research 1996;6(3):187-94.
1996: Pai L H; Wittes R; Setser A; Willingham M C; Pastan I
Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin.
Nature medicine 1996;2(3):350-3.
1996: Kuan C T; Pastan I
Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
Biochemistry 1996;35(9):2872-7.
1996: Reiter Y; Pastan I
Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):245-52.
1996: Kuan C T; Pastan I
Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):974-8.
1996: Prior T I; Kunwar S; Pastan I
Studies on the activity of barnase toxins in vitro and in vivo.
Bioconjugate chemistry 1996;7(1):23-9.
1996: Germann U A; Chambers T C; Ambudkar S V; Licht T; Cardarelli C O; Pastan I; Gottesman M M
Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells.
The Journal of biological chemistry 1996;271(3):1708-16.
1996: Chang K; Pastan I
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):136-40.
1996: Pastan I; Pai L H; Brinkmann U; FitzGerald D
Recombinant immunotoxins.
Breast cancer research and treatment 1996;38(1):3-9.
1995: Kuan C T; Pai L H; Pastan I
Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1589-94.
1995: Bigner D D; Archer G E; McLendon R E; Friedman H S; Fuchs H E; Pai L H; Herndon J E; Pastan I H
Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1545-55.
1995: Reiter Y; Brinkmann U; Jung S H; Pastan I; Lee B
Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation.
Protein engineering 1995;8(12):1323-31.
1995: Debinski W; Obiri N I; Powers S K; Pastan I; Puri R K
Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1253-8.
1995: Campain J A; Slovak M L; Schoenlein P V; Popescu N C; Gottesman M M; Pastan I
Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines.
Somatic cell and molecular genetics 1995;21(6):451-71.
1995: Berger D P; Herbstritt L; Hellerich U; Schulzke S; Dengler W A; Gallo M; Pastan I; Mertelsmann R; Fiebig H H
Cytotoxicity of TGF alpha-PE40 and correlation to expression of epidermal growth factor receptor.
European journal of cancer (Oxford, England : 1990) 1995;31A(12):2067-72.
1995: Choi C W; Lang L; Lee J T; Webber K O; Yoo T M; Chang H K; Le N; Jagoda E; Paik C H; Pastan I
Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.
Cancer research 1995;55(22):5323-9.
1995: Kreitman R J; Pastan I
Targeting Pseudomonas exotoxin to hematologic malignancies.
Seminars in cancer biology 1995;6(5):297-306.
1995: Chambers T C; Germann U A; Gottesman M M; Pastan I; Kuo J F; Ambudkar S V
Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.
Biochemistry 1995;34(43):14156-62.
1995: Benhar I; Pastan I
Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
The Journal of biological chemistry 1995;270(40):23373-80.
1995: Brinkmann U; Brinkmann E; Gallo M; Pastan I
Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10427-31.
1995: Benhar I; Pastan I
Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(9):1023-9.
1995: Debinski W; Pastan I
Recombinant F(ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(9):1015-22.
1995: Li M; Dyda F; Benhar I; Pastan I; Davies D R
The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9308-12.
1995: Lorimer I A; Wikstrand C J; Batra S K; Bigner D D; Pastan I
Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):859-64.
1995: Lorimer I A; Pastan I
Random recombination of antibody single chain Fv sequences after fragmentation with DNaseI in the presence of Mn2+.
Nucleic acids research 1995;23(15):3067-8.
1995: Kreitman R J; Puri R K; Pastan I
Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.
Cancer research 1995;55(15):3357-63.
1995: Licht T; Aksentijevich I; Gottesman M M; Pastan I
Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells.
Blood 1995;86(1):111-21.
1995: Benhar I; Reiter Y; Pai L H; Pastan I
Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
International journal of cancer. Journal international du cancer 1995;62(3):351-5.
1995: Debinski W; Obiri N I; Pastan I; Puri R K
A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4.
The Journal of biological chemistry 1995;270(28):16775-80.
1995: Sugimoto Y; Aksentijevich I; Murray G J; Brady R O; Pastan I; Gottesman M M
Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease.
Human gene therapy 1995;6(7):905-15.
1995: Beguinot L; Yamazaki H; Pastan I; Johnson A C
Biochemical characterization of human GCF transcription factor in tumor cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(6):699-706.
1995: Pastan I H; Pai L H; Brinkmann U; Fitzgerald D J
Recombinant toxins: new therapeutic agents for cancer.
Annals of the New York Academy of Sciences 1995;758():345-54.
1995: Kreitman R J; Puri R K; McPhie P; Pastan I
Circularly permuted interleukin 4 retains proliferative and binding activity.
Cytokine 1995;7(4):311-8.
1995: Brinkmann U; Chowdhury P S; Roscoe D M; Pastan I
Phage display of disulfide-stabilized Fv fragments.
Journal of immunological methods 1995;182(1):41-50.
1995: Kreitman R J; Pastan I
Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor.
The Biochemical journal 1995;307 ( Pt 1)():29-37.
1995: Shen D W; Akiyama S; Schoenlein P; Pastan I; Gottesman M M
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.
British journal of cancer 1995;71(4):676-83.
1995: Licht T; Gottesman M M; Pastan I
Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo.
Cytokines and molecular therapy 1995;1(1):11-20.
1995: Cardarelli C O; Aksentijevich I; Pastan I; Gottesman M M
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Cancer research 1995;55(5):1086-91.
1995: Webber K O; Reiter Y; Brinkmann U; Kreitman R; Pastan I
Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog.
Molecular immunology 1995;32(4):249-58.
1995: Pastan I H; Archer G E; McLendon R E; Friedman H S; Fuchs H E; Wang Q C; Pai L H; Herndon J; Bigner D D
Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2765-9.
1995: Reiter Y; Kurucz I; Brinkmann U; Jung S H; Lee B; Segal D M; Pastan I
Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure.
Immunity 1995;2(3):281-7.
1995: Kobayashi K; Morita S; Sawada H; Mizuguchi T; Yamada K; Nagatsu I; Fujita K; Kreitman R J; Pastan I; Nagatsu T
Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1132-6.
1995: Germann U A; Chambers T C; Ambudkar S V; Pastan I; Gottesman M M
Effects of phosphorylation of P-glycoprotein on multidrug resistance.
Journal of bioenergetics and biomembranes 1995;27(1):53-61.
1995: Evans G L; Ni B; Hrycyna C A; Chen D; Ambudkar S V; Pastan I; Germann U A; Gottesman M M
Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.
Journal of bioenergetics and biomembranes 1995;27(1):43-52.
1995: Brinkmann U; Brinkmann E; Pastan I
Expression cloning of cDNAs that render cancer cells resistant to Pseudomonas and diphtheria toxin and immunotoxins.
Molecular medicine (Cambridge, Mass.) 1995;1(2):206-16.
1995: Webber K O; Kreitman R J; Pastan I
Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.
Cancer research 1995;55(2):318-23.
1995: Kihara A; Pastan I
Cytotoxic activity of chimeric toxins containing the epidermal growth factor-like domain of heregulins fused to PE38KDEL, a truncated recombinant form of Pseudomonas exotoxin.
Cancer research 1995;55(1):71-7.
1995: Gottesman M M; Hrycyna C A; Schoenlein P V; Germann U A; Pastan I
Genetic analysis of the multidrug transporter.
Annual review of genetics 1995;29():607-49.
1994: Benhar I; Padlan E A; Jung S H; Lee B; Pastan I
Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12051-5.
1994: Benhar I; Pastan I
Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.
Protein engineering 1994;7(12):1509-15.
1994: Roscoe D M; Jung S H; Benhar I; Pai L; Lee B K; Pastan I
Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin.
Infection and immunity 1994;62(11):5055-65.
1994: Kihara A; Pastan I
Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha.
Bioconjugate chemistry 1994;5(6):532-8.
1994: Licht T; Pastan I; Gottesman M; Herrmann F
P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells.
Annals of hematology 1994;69(4):159-71.
1994: Kihara A; Pastan I
Small chimeric toxins containing only transforming growth factor alpha and domain III of Pseudomonas exotoxin with good antitumor activity in mice.
Cancer research 1994;54(19):5154-9.
1994: Debinski W; Puri R K; Pastan I
Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 1994;58(5):744-8.
1994: Kreitman R J; Puri R K; Leland P; Lee B; Pastan I
Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity.
Biochemistry 1994;33(38):11637-44.
1994: Mesri E A; Ono M; Kreitman R J; Klagsbrun M; Pastan I
The heparin-binding domain of heparin-binding EGF-like growth factor can target Pseudomonas exotoxin to kill cells exclusively through heparan sulfate proteoglycans.
Journal of cell science 1994;107 ( Pt 9)():2599-608.
1994: Campain J A; Gottesman M M; Pastan I
A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.
Biochemistry 1994;33(37):11327-32.
1994: Puri R K; Leland P; Kreitman R J; Pastan I
Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein.
International journal of cancer. Journal international du cancer 1994;58(4):574-81.
1994: Morris D I; Greenberger L M; Bruggemann E P; Cardarelli C; Gottesman M M; Pastan I; Seamon K B
Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.
Molecular pharmacology 1994;46(2):329-37.
1994: Lelong I H; Cardarelli C O; Gottesman M M; Pastan I
GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells.
Biochemistry 1994;33(30):8921-9.
1994: Germann U A; Schoenlein P V; Zimonjic D B; Popescu N C; Pastan I; Gottesman M M
Putative "MDR enhancer" is located on human chromosome 20 and not linked to the MDR1 gene on chromosome 7.
Genes, chromosomes & cancer 1994;10(4):267-74.
1994: Kreitman R J; Puri R K; Pastan I
A circularly permuted recombinant interleukin 4 toxin with increased activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6889-93.
1994: Reiter Y; Kreitman R J; Brinkmann U; Pastan I
Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 1994;58(1):142-9.
1994: Choe M; Webber K O; Pastan I
B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.
Cancer research 1994;54(13):3460-7.
1994: Camera L; Kinuya S; Garmestani K; Brechbiel M W; Wu C; Pai L H; McMurry T J; Gansow O A; Pastan I; Paik C H
Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA).
European journal of nuclear medicine 1994;21(7):640-6.
1994: Benhar I; Brinkmann U; Webber K O; Pastan I
Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.
Bioconjugate chemistry 1994;5(4):321-6.
1994: Reiter Y; Brinkmann U; Jung S H; Lee B; Kasprzyk P G; King C R; Pastan I
Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
The Journal of biological chemistry 1994;269(28):18327-31.
1994: Sugimoto Y; Aksentijevich I; Gottesman M M; Pastan I
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
Bio/technology (Nature Publishing Company) 1994;12(7):694-8.
1994: Kreitman R J; Chang C N; Hudson D V; Queen C; Bailon P; Pastan I
Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model.
International journal of cancer. Journal international du cancer 1994;57(6):856-64.
1994: Brinkmann U; Pastan I
Immunotoxins against cancer.
Biochimica et biophysica acta 1994;1198(1):27-45.
1994: Theuer C; Kasturi S; Pastan I
Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes.
Biochemistry 1994;33(19):5894-900.
1994: Camera L; Kinuya S; Garmestani K; Wu C; Brechbiel M W; Pai L H; McMurry T J; Gansow O A; Pastan I; Paik C H
Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(5):882-9.
1994: Benhar I; Wang Q C; FitzGerald D; Pastan I
Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
The Journal of biological chemistry 1994;269(18):13398-404.
1994: Reiter Y; Pai L H; Brinkmann U; Wang Q C; Pastan I
Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Cancer research 1994;54(10):2714-8.
1994: Reiter Y; Brinkmann U; Webber K O; Jung S H; Lee B; Pastan I
Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
Protein engineering 1994;7(5):697-704.
1994: Jung S H; Pastan I; Lee B
Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3.
Proteins 1994;19(1):35-47.
1994: Gottesman M M; Germann U A; Aksentijevich I; Sugimoto Y; Cardarelli C O; Pastan I
Gene transfer of drug resistance genes. Implications for cancer therapy.
Annals of the New York Academy of Sciences 1994;716():126-38; discussion 138-43.
1994: Reiter Y; Brinkmann U; Kreitman R J; Jung S H; Lee B; Pastan I
Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
Biochemistry 1994;33(18):5451-9.
1994: Siegsmund M J; Yamazaki H; Pastan I
Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.
The Journal of urology 1994;151(5):1396-9.
1994: Chang K; Pastan I
Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line.
International journal of cancer. Journal international du cancer 1994;57(1):90-7.
1994: Puri R K; Mehrotra P T; Leland P; Kreitman R J; Siegel J P; Pastan I
A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3693-700.
1994: Puri R K; Debinski W; Obiri N; Kreitman R; Pastan I
Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin.
Cellular immunology 1994;154(1):369-79.
1994: Stein W D; Cardarelli C; Pastan I; Gottesman M M
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.
Molecular pharmacology 1994;45(4):763-72.
1994: Aran J M; Gottesman M M; Pastan I
Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3176-80.
1994: Kuan C T; Wang Q C; Pastan I
Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
The Journal of biological chemistry 1994;269(10):7610-6.
1994: Kreitman R J; Pastan I
Recombinant single-chain immunotoxins against T and B cell leukemias.
Leukemia & lymphoma 1994;13(1-2):1-10.
1994: Saito T; Kreitman R J; Hanada S; Makino T; Utsunomiya A; Sumizawa T; Arima T; Chang C N; Hudson D; Pastan I
Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor.
Cancer research 1994;54(4):1059-64.
1994: Phillips P C; Levow C; Catterall M; Colvin O M; Pastan I; Brem H
Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.
Cancer research 1994;54(4):1008-15.
1994: Siegsmund M J; Cardarelli C; Aksentijevich I; Sugimoto Y; Pastan I; Gottesman M M
Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells.
The Journal of urology 1994;151(2):485-91.
1994: Kreitman R J; Bailon P; Chaudhary V K; FitzGerald D J; Pastan I
Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma.
Blood 1994;83(2):426-34.
1994: Debinski W; Pastan I
An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin.
Bioconjugate chemistry 1994;5(1):40-6.
1994: Siegall C B; Gawlak S L; Chace D F; Merwin J R; Pastan I
In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins.
Bioconjugate chemistry 1994;5(1):77-83.
1994: Draoui M; Siegall C B; FitzGerald D; Pastan I; Moody T W
TGF alpha-PE40 inhibits non-small cell lung cancer growth.
Life sciences 1994;54(7):445-53.
1994: Pai L H; Pastan I
Immunotoxins and recombinant toxins for cancer treatment.
Important advances in oncology 1994;():3-19.
1994: Kreitman R J; Pastan I
Recombinant toxins.
Advances in pharmacology (San Diego, Calif.) 1994;28():193-219.
1994: Kameyama S; Kawamata H; Pastan I; Oyasu R
Cytotoxic effect of a fusion protein from transforming growth factor alpha and Pseudomonas exotoxin on rat and human bladder carcinoma cells in vitro.
Journal of cancer research and clinical oncology 1994;120(9):507-12.
1994: Nguyen K T; Liu B; Ueda K; Gottesman M M; Pastan I; Chin K V
Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.
Oncology research 1994;6(2):71-7.
1994: Fischer P H; Bird R E; Kasprzyk P G; King C R; Turner N A; Pastan I; Kihara A; Batra J
In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein.
Advances in enzyme regulation 1994;34():119-28.
1994: Gottesman M M; Mickisch G H; Pastan I
In vivo models of P-glycoprotein-mediated multidrug resistance.
Cancer treatment and research 1994;73():107-28.
1994: Gottesman M M; Ambudkar S V; Ni B; Aran J M; Sugimoto Y; Cardarelli C O; Pastan I
Exploiting multidrug resistance to treat cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():677-83.
1993: Altuvia S; Stein W D; Goldenberg S; Kane S E; Pastan I; Gottesman M M
Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.
The Journal of biological chemistry 1993;268(36):27127-32.
1993: Kreitman R J; Pastan I
Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.
Bioconjugate chemistry 1993;4(6):581-5.
1993: Camera L; Kinuya S; Garmestani K; Pai L H; Brechbiel M W; Gansow O A; Paik C H; Pastan I; Carrasquillo J A
Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts.
Nuclear medicine and biology 1993;20(8):955-62.
1993: Leamon C P; Pastan I; Low P S
Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain.
The Journal of biological chemistry 1993;268(33):24847-54.
1993: Gawlak S L; Pastan I; Siegall C B
Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin.
Bioconjugate chemistry 1993;4(6):483-9.
1993: Zdanovsky A G; Chiron M; Pastan I; FitzGerald D J
Mechanism of action of Pseudomonas exotoxin. Identification of a rate-limiting step.
The Journal of biological chemistry 1993;268(29):21791-9.
1993: Wang Q C; Pai L H; Debinski W; FitzGerald D J; Pastan I
Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.
Cancer research 1993;53(19):4588-94.
1993: Homolya L; Holló Z; Germann U A; Pastan I; Gottesman M M; Sarkadi B
Fluorescent cellular indicators are extruded by the multidrug resistance protein.
The Journal of biological chemistry 1993;268(29):21493-6.
1993: Pastan I
c-erbB-2 and human cancer.
Japanese journal of cancer research : Gann 1993;84(10):inside front cover.
1993: Kunwar S; Pai L H; Pastan I
Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells.
Journal of neurosurgery 1993;79(4):569-76.
1993: Theuer C P; Pastan I
Immunotoxins and recombinant toxins in the treatment of solid carcinomas.
American journal of surgery 1993;166(3):284-8.
1993: Fu Y M; Mesri E A; Yu Z X; Kreitman R J; Pastan I; Epstein S E
Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin.
Cardiovascular research 1993;27(9):1691-7.
1993: Xu Y H; Peng S F; Jiang W L; Zhu Y; Chandhary V; FitzGerald D; Pastan I
[Gene cloning, expression of fusion protein TGF alpha-PE 40 and its inhibition activity on cancer cell growth]
Shi yan sheng wu xue bao 1993;26(3):289-95.
1993: Theuer C P; Buchner J; FitzGerald D; Pastan I
The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7774-8.
1993: Brinkmann U; Reiter Y; Jung S H; Lee B; Pastan I
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7538-42.
1993: Debinski W; Puri R K; Kreitman R J; Pastan I
A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin.
The Journal of biological chemistry 1993;268(19):14065-70.
1993: Pastan I; Lovelace E; Rutherford A V; Kunwar S; Willingham M C; Peehl D M
PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells.
Journal of the National Cancer Institute 1993;85(14):1149-54.
1993: Jhappan C; Stahle C; Wolff M; Merlino G; Pastan I
An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice.
Cellular immunology 1993;149(1):99-106.
1993: Camera L; Kinuya S; Pai L H; Garmestani K; Brechbiel M W; Gansow O A; Paik C H; Pastan I; Carrasquillo J A
Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts.
Cancer research 1993;53(12):2834-9.
1993: Theuer C P; FitzGerald D J; Pastan I
A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer.
The Journal of urology 1993;149(6):1626-32.
1993: Fitzgerald D; Pastan I
Pseudomonas exotoxin and recombinant immunotoxins derived from it.
Annals of the New York Academy of Sciences 1993;685():740-5.
1993: Hoess R; Brinkmann U; Handel T; Pastan I
Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3.
Gene 1993;128(1):43-9.
1993: Campain J A; Padmanabhan R; Hwang J; Gottesman M M; Pastan I
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.
Journal of cellular physiology 1993;155(2):414-25.
1993: Kitadai Y; Yamazaki H; Yasui W; Kyo E; Yokozaki H; Kajiyama G; Johnson A C; Pastan I; Tahara E
GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):291-6.
1993: Kreitman R J; Chaudhary V K; Waldmann T A; Hanchard B; Cranston B; FitzGerald D J; Pastan I
Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(4):553-62.
1993: Brinkmann U; Lee B K; Pastan I
Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2774-82.
1993: Batra J K; Kasturi S; Gallo M G; Voorman R L; Maio S M; Chaudhary V K; Pastan I
Insertion of constant region domains of human IgG1 into CD4-PE40 increases its plasma half-life.
Molecular immunology 1993;30(4):379-86.
1993: Mesri E A; Kreitman R J; Fu Y M; Epstein S E; Pastan I
Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells.
The Journal of biological chemistry 1993;268(7):4853-62.
1993: Fattom A; Schneerson R; Watson D C; Karakawa W W; Fitzgerald D; Pastan I; Li X; Shiloach J; Bryla D A; Robbins J B
Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A.
Infection and immunity 1993;61(3):1023-32.
1993: Kreitman R J; Batra J K; Seetharam S; Chaudhary V K; FitzGerald D J; Pastan I
Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.
Bioconjugate chemistry 1993;4(2):112-20.
1993: Kreitman R J; Hansen H J; Jones A L; FitzGerald D J; Goldenberg D M; Pastan I
Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice.
Cancer research 1993;53(4):819-25.
1993: Germann U A; Pastan I; Gottesman M M
P-glycoproteins: mediators of multidrug resistance.
Seminars in cell biology 1993;4(1):63-76.
1993: Spence C; Nachman M; Gately M K; Kreitman R J; Pastan I; Bailon P
Affinity purification and characterization of anti-Tac(Fv)-C3-PE38KDEL: A highly potent cytotoxic agent specific to cells bearing IL-2 receptors.
Bioconjugate chemistry 1993;4(1):63-8.
1993: Brinkmann U; Gallo M; Brinkmann E; Kunwar S; Pastan I
A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):547-51.
1993: Theuer C P; Kreitman R J; FitzGerald D J; Pastan I
Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity.
Cancer research 1993;53(2):340-7.
1993: Mickisch G H; Pai L H; Siegsmund M; Campain J; Gottesman M M; Pastan I
Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice.
The Journal of urology 1993;149(1):174-8.
1993: Pai L H; Pastan I
Immunotoxin therapy for cancer.
JAMA : the journal of the American Medical Association 1993;269(1):78-81.
1993: Chin K V; Pastan I; Gottesman M M
Function and regulation of the human multidrug resistance gene.
Advances in cancer research 1993;60():157-80.
1993: Pastan I H
Recombinant immunotoxins: new therapeutic agents for cancer treatment.
Cancer detection and prevention 1993;17(2):289-93.
1993: Pai L H; Pastan I
The use of immunotoxins for cancer therapy.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1606-9.
1993: Gottesman M M; Pastan I
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Annual review of biochemistry 1993;62():385-427.
1992: Ogata M; Fryling C M; Pastan I; FitzGerald D J
Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.
The Journal of biological chemistry 1992;267(35):25396-401.
1992: Currier S J; Kane S E; Willingham M C; Cardarelli C O; Pastan I; Gottesman M M
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
The Journal of biological chemistry 1992;267(35):25153-9.
1992: DelaFlor-Weiss E; Richardson C; Ward M; Himelstein A; Smith L; Podda S; Gottesman M; Pastan I; Bank A
Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.
Blood 1992;80(12):3106-11.
1992: FitzGerald D J; Pastan I
Pseudomonas exotoxin: recombinant conjugates as therapeutic agents.
Biochemical Society transactions 1992;20(4):731-4.
1992: Kasturi S; Kihara A; FitzGerald D; Pastan I
Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm.
The Journal of biological chemistry 1992;267(32):23427-33.
1992: Kreitman R J; Chaudhary V K; Kozak R W; FitzGerald D J; Waldman T A; Pastan I
Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.
Blood 1992;80(9):2344-52.
1992: Kreitman R J; Schneider W P; Queen C; Tsudo M; Fitzgerald D J; Waldmann T A; Pastan I
Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2810-5.
1992: Debinski W; Pastan I
Monovalent immunotoxin containing truncated form of Pseudomonas exotoxin as potent antitumor agent.
Cancer research 1992;52(19):5379-85.
1992: Podda S; Ward M; Himelstein A; Richardson C; de la Flor-Weiss E; Smith L; Gottesman M; Pastan I; Bank A
Transfer and expression of the human multiple drug resistance gene into live mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9676-80.
1992: Bruggemann E P; Currier S J; Gottesman M M; Pastan I
Characterization of the azidopine and vinblastine binding site of P-glycoprotein.
The Journal of biological chemistry 1992;267(29):21020-6.
1992: Puri R K; FitzGerald D; Leland P; Kozak R W; Pastan I
In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin.
Cellular immunology 1992;143(2):324-34.
1992: Merwin J R; Lynch M J; Madri J A; Pastan I; Siegall C B
Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.
Cancer research 1992;52(18):4995-5001.
1992: Ambudkar S V; Lelong I H; Zhang J; Cardarelli C O; Gottesman M M; Pastan I
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8472-6.
1992: Buchner J; Pastan I; Brinkmann U
A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.
Analytical biochemistry 1992;205(2):263-70.
1992: Biro S; Siegall C B; Fu Y M; Speir E; Pastan I; Epstein S E
In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells.
Circulation research 1992;71(3):640-5.
1992: Debinski W; Karlsson B; Lindholm L; Siegall C B; Willingham M C; FitzGerald D; Pastan I
Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice.
The Journal of clinical investigation 1992;90(2):405-11.
1992: Theuer C P; FitzGerald D; Pastan I
A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing.
The Journal of biological chemistry 1992;267(24):16872-7.
1992: Mickisch G H; Pai L H; Gottesman M M; Pastan I
Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.
Cancer research 1992;52(16):4427-32.
1992: Batra J K; Kasprzyk P G; Bird R E; Pastan I; King C R
Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5867-71.
1992: Sorrentino B P; Brandt S J; Bodine D; Gottesman M; Pastan I; Cline A; Nienhuis A W
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
Science (New York, N.Y.) 1992;257(5066):99-103.
1992: Chin K V; Chauhan S S; Abraham I; Sampson K E; Krolczyk A J; Wong M; Schimmer B; Pastan I; Gottesman M M
Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.
Journal of cellular physiology 1992;152(1):87-94.
1992: Pai L H; Batra J K; FitzGerald D J; Willingham M C; Pastan I
Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys.
Cancer research 1992;52(11):3189-93.
1992: Buchner J; Brinkmann U; Pastan I
Renaturation of a single-chain immunotoxin facilitated by chaperones and protein disulfide isomerase.
Bio/technology (Nature Publishing Company) 1992;10(6):682-5.
1992: Lelong I H; Padmanabhan R; Lovelace E; Pastan I; Gottesman M M
ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-V1 plasma membrane vesicles.
FEBS letters 1992;304(2-3):256-60.
1992: Chang K; Pastan I; Willingham M C
Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas.
International journal of cancer. Journal international du cancer 1992;51(4):548-54.
1992: Schoenlein P V; Shen D W; Barrett J T; Pastan I; Gottesman M M
Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.
Molecular biology of the cell 1992;3(5):507-20.
1992: Mickisch G H; Rahman A; Pastan I; Gottesman M M
Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin.
Journal of the National Cancer Institute 1992;84(10):804-5.
1992: Prior T I; FitzGerald D J; Pastan I
Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol.
Biochemistry 1992;31(14):3555-9.
1992: Kreitman R J; Siegall C B; FitzGerald D J; Epstein J; Barlogie B; Pastan I
Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma.
Blood 1992;79(7):1775-80.
1992: Brinkmann U; Buchner J; Pastan I
Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3075-9.
1992: Brinkmann U; Pai L H; FitzGerald D J; Pastan I
Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3065-9.
1992: Kreitman R J; FitzGerald D; Pastan I
Targeting growth factor receptors with fusion toxins.
International journal of immunopharmacology 1992;14(3):465-72.
1992: Chang K; Pai L H; Pass H; Pogrebniak H W; Tsao M S; Pastan I; Willingham M C
Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma.
The American journal of surgical pathology 1992;16(3):259-68.
1992: Mickisch G H; Aksentijevich I; Schoenlein P V; Goldstein L J; Galski H; Stahle C; Sachs D H; Pastan I; Gottesman M M
Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.
Blood 1992;79(4):1087-93.
1992: Chang K; Pastan I; Willingham M C
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium.
International journal of cancer. Journal international du cancer 1992;50(3):373-81.
1992: Fattom A; Shiloach J; Bryla D; Fitzgerald D; Pastan I; Karakawa W W; Robbins J B; Schneerson R
Comparative immunogenicity of conjugates composed of the Staphylococcus aureus type 8 capsular polysaccharide bound to carrier proteins by adipic acid dihydrazide or N-succinimidyl-3-(2-pyridyldithio)propionate.
Infection and immunity 1992;60(2):584-9.
1992: Waldmann T A; Pastan I H; Gansow O A; Junghans R P
The multichain interleukin-2 receptor: a target for immunotherapy.
Annals of internal medicine 1992;116(2):148-60.
1992: Chang K; Pai L H; Batra J K; Pastan I; Willingham M C
Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium.
Cancer research 1992;52(1):181-6.
1992: Kreitman R J; Siegall C B; Chaudhary V K; FitzGerald D J; Pastan I
Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin.
Bioconjugate chemistry 1992;3(1):63-8.
1992: Kreitman R J; Chaudhary V K; Siegall C B; FitzGerald D J; Pastan I
Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand.
Bioconjugate chemistry 1992;3(1):58-62.
1992: Johnson A C; Kageyama R; Popescu N C; Pastan I
Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.
The Journal of biological chemistry 1992;267(3):1689-94.
1992: Chin K V; Ueda K; Pastan I; Gottesman M M
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
Science (New York, N.Y.) 1992;255(5043):459-62.
1992: FitzGerald D; Chaudhary V K; Kreitman R J; Siegall C B; Pastan I
Generation of chimeric toxins.
Targeted diagnosis and therapy 1992;7():447-62.
1992: Pastan I; Chaudhary V; FitzGerald D J
Recombinant toxins as novel therapeutic agents.
Annual review of biochemistry 1992;61():331-54.
1992: Goldstein L J; Pastan I; Gottesman M M
Multidrug resistance in human cancer.
Critical reviews in oncology/hematology 1992;12(3):243-53.
1991: Pastan I; FitzGerald D
Recombinant toxins for cancer treatment.
Science (New York, N.Y.) 1991;254(5035):1173-7.
1991: Chaudhary V K; FitzGerald D J; Pastan I
A proper amino terminus of diphtheria toxin is important for cytotoxicity.
Biochemical and biophysical research communications 1991;180(2):545-51.
1991: Brinkmann U; Pai L H; FitzGerald D J; Willingham M; Pastan I
B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8616-20.
1991: Siegall C B; Epstein S; Speir E; Hla T; Forough R; Maciag T; Fitzgerald D J; Pastan I
Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(13):2843-9.
1991: Lelong I H; Guzikowski A P; Haugland R P; Pastan I; Gottesman M M; Willingham M C
Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.
Molecular pharmacology 1991;40(4):490-4.
1991: Mickisch G H; Licht T; Merlino G T; Gottesman M M; Pastan I
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Cancer research 1991;51(19):5417-24.
1991: Seetharam S; Chaudhary V K; FitzGerald D; Pastan I
Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.
The Journal of biological chemistry 1991;266(26):17376-81.
1991: Herbort C P; de Smet M D; Roberge F G; Nussenblatt R B; FitzGerald D; Lorberboum-Galski H; Pastan I
Treatment of corneal allograft rejection with the cytotoxin IL-2-PE40.
Transplantation 1991;52(3):470-4.
1991: Pastan I; Willingham M C; Gottesman M
Molecular manipulations of the multidrug transporter: a new role for transgenic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(11):2523-8.
1991: Epstein S E; Siegall C B; Biro S; Fu Y M; FitzGerald D; Pastan I
Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells.
Circulation 1991;84(2):778-87.
1991: Mickisch G H; Pastan I; Gottesman M M
Multidrug resistant transgenic mice as a novel pharmacologic tool.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(8):381-7.
1991: Mickisch G H; Merlino G T; Aiken P M; Gottesman M M; Pastan I
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
The Journal of urology 1991;146(2):447-53.
1991: Siegall C B; Ogata M; Pastan I; FitzGerald D J
Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation.
Biochemistry 1991;30(29):7154-9.
1991: Pastan I; Lovelace E T; Gallo M G; Rutherford A V; Magnani J L; Willingham M C
Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas.
Cancer research 1991;51(14):3781-7.
1991: Puri R K; Ogata M; Leland P; Feldman G M; FitzGerald D; Pastan I
Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin.
Cancer research 1991;51(11):3011-7.
1991: Pai L H; Gallo M G; FitzGerald D J; Pastan I
Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).
Cancer research 1991;51(11):2808-12.
1991: Siegall C B; Kreitman R J; FitzGerald D J; Pastan I
Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.
Cancer research 1991;51(11):2831-6.
1991: Rose J W; Lorberboum-Galski H; Fitzgerald D; McCarron R; Hill K E; Townsend J J; Pastan I
Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis.
Journal of neuroimmunology 1991;32(3):209-17.
1991: Pai L H; Batra J K; FitzGerald D J; Willingham M C; Pastan I
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3358-62.
1991: Batra J K; Fitzgerald D J; Chaudhary V K; Pastan I
Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).
Molecular and cellular biology 1991;11(4):2200-5.
1991: Beraud E; Lorberboum-Galski H; Chan C C; FitzGerald D; Pastan I; Nussenblatt R B
Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40.
Cellular immunology 1991;133(2):379-89.
1991: Padmanabhan R; Tsuruo T; Kane S E; Willingham M C; Howard B H; Gottesman M M; Pastan I
Magnetic-affinity cell sorting of human multidrug-resistant cells.
Journal of the National Cancer Institute 1991;83(8):565-9.
1991: Heimbrook D C; Stirdivant S M; Ahern J D; Balishin N L; Patrick D R; Edwards G M; Defeo-Jones D; FitzGerald D J; Pastan I; Oliff A
Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo.
Journal of industrial microbiology 1991;7(3):203-7.
1991: Prior T I; FitzGerald D J; Pastan I
Barnase toxin: a new chimeric toxin composed of pseudomonas exotoxin A and barnase.
Cell 1991;64(5):1017-23.
1991: Shen D W; Lu Y G; Chin K V; Pastan I; Gottesman M M
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
Journal of cell science 1991;98 ( Pt 3)():317-22.
1991: Debinski W; Siegall C B; Fitzgerald D; Pastan I
Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.
Molecular and cellular biology 1991;11(3):1751-3.
1991: FitzGerald D; Pastan I
Redirecting Pseudomonas exotoxin.
Seminars in cell biology 1991;2(1):31-7.
1991: Bruggemann E P; Chaudhary V; Gottesman M M; Pastan I
Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein.
BioTechniques 1991;10(2):202-4, 206, 208-9.
1991: Prior T I; Helman L J; FitzGerald D J; Pastan I
Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin.
Cancer research 1991;51(1):174-80.
1991: Ogata M; Pastan I; FitzGerald D
Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes.
Infection and immunity 1991;59(1):407-14.
1991: Horio M; Lovelace E; Pastan I; Gottesman M M
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Biochimica et biophysica acta 1991;1061(1):106-10.
1991: Mickisch G H; Merlino G T; Galski H; Gottesman M M; Pastan I
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):547-51.
1991: Lorberboum-Galski H; Lafyatis R; Case J P; FitzGerald D; Wilder R L; Pastan I
Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion.
International journal of immunopharmacology 1991;13(2-3):305-15.
1991: Pastan I; Gottesman M M
Multidrug resistance.
Annual review of medicine 1991;42():277-86.
1991: Galski H; Merlino G T; Gottesman M M; Pastan I
Expression of a human multidrug-resistance cDNA (MDR1) under the control of a beta-actin promoter in transgenic mice.
Biotechnology (Reading, Mass.) 1991;16():103-24.
1991: Horio M; Kakihara M; Nakahama H; Fukuhara Y; Ueda N; Orita Y; Kamada T; Pastan I; Handler J
Kidney-derived cells show multidrug secretory transport.
Contributions to nephrology 1991;95():143-8.
1991: Goldstein L J; Gottesman M M; Pastan I
Expression of the MDR1 gene in human cancers.
Cancer treatment and research 1991;57():101-19.
1990: Siegall C B; Schwab G; Nordan R P; FitzGerald D J; Pastan I
Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.
Cancer research 1990;50(24):7786-8.
1990: Pai L H; FitzGerald D J; Tepper M; Schacter B; Spitalny G; Pastan I
Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.
Cancer research 1990;50(24):7750-3.
1990: Chaudhary V K; Gallo M G; FitzGerald D J; Pastan I
A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9491-4.
1990: Kreitman R J; Chaudhary V K; Waldmann T; Willingham M C; FitzGerald D J; Pastan I
The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8291-5.
1990: Ogata M; Chaudhary V K; Pastan I; FitzGerald D J
Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol.
The Journal of biological chemistry 1990;265(33):20678-85.
1990: Ashorn P; Moss B; Weinstein J N; Chaudhary V K; FitzGerald D J; Pastan I; Berger E A
Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8889-93.
1990: Kozak R W; Lorberboum-Galski H; Jones L; Puri R K; Willingham M C; Malek T; Fitzgerald D J; Waldmann T A; Pastan I
IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2766-71.
1990: Siegall C B; FitzGerald D J; Pastan I
Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules.
Seminars in cancer biology 1990;1(5):345-50.
1990: Siegall C B; FitzGerald D J; Pastan I
Cytotoxicity of IL6-PE40 and derivatives on tumor cells expressing a range of interleukin 6 receptor levels.
The Journal of biological chemistry 1990;265(27):16318-23.
1990: Chaudhary V K; Jinno Y; Gallo M G; FitzGerald D; Pastan I
Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity.
The Journal of biological chemistry 1990;265(27):16306-10.
1990: Batra J K; FitzGerald D; Gately M; Chaudhary V K; Pastan I
Anti-Tac(Fv)-PE40, a single chain antibody Pseudomonas fusion protein directed at interleukin 2 receptor bearing cells.
The Journal of biological chemistry 1990;265(25):15198-202.
1990: Sugawara I; Koji T; Ueda K; Pastan I; Gottesman M M; Nakane P K; Mori S
In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA.
Japanese journal of cancer research : Gann 1990;81(9):949-55.
1990: Lorberboum-Galski H; Garsia R J; Gately M; Brown P S; Clark R E; Waldmann T A; Chaudhary V K; FitzGerald D J; Pastan I
IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.
The Journal of biological chemistry 1990;265(27):16311-7.
1990: Batra J K; Chaudhary V K; FitzGerald D; Pastan I
TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors.
Biochemical and biophysical research communications 1990;171(1):1-6.
1990: McLachlin J R; Eglitis M A; Ueda K; Kantoff P W; Pastan I H; Anderson W F; Gottesman M M
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.
Journal of the National Cancer Institute 1990;82(15):1260-3.
1990: Horio M; Pastan I; Gottesman M M; Handler J S
Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.
Biochimica et biophysica acta 1990;1027(2):116-22.
1990: Kane S E; Pastan I; Gottesman M M
Genetic basis of multidrug resistance of tumor cells.
Journal of bioenergetics and biomembranes 1990;22(4):593-618.
1990: Chin K V; Chauhan S S; Pastan I; Gottesman M M
Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(8):361-5.
1990: Tomasselli A G; Hui J O; Sawyer T K; Staples D J; Bannow C A; Reardon I M; Chaudhary V K; Fryling C M; Pastan I; Fitzgerald D J
Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates.
Journal of virology 1990;64(7):3157-61.
1990: FitzGerald D; Idziorek T; Batra J K; Willingham M; Pastan I
Antitumor activity of a thioether-linked immunotoxin: OVB3-PE.
Bioconjugate chemistry 1990;1(4):264-8.
1990: Heimbrook D C; Stirdivant S M; Ahern J D; Balishin N L; Patrick D R; Edwards G M; Defeo-Jones D; FitzGerald D J; Pastan I; Oliff A
Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4697-701.
1990: Tyagi J S; Pastan I
Purification of calf thymus RNA polymerase II for in vitro transcription studies.
Journal of biochemical and biophysical methods 1990;21(1):1-8.
1990: Siegall C B; Nordan R P; FitzGerald D J; Pastan I
Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells.
Molecular and cellular biology 1990;10(6):2443-7.
1990: Berger E A; Chaudhary V K; Clouse K A; Jaraquemada D; Nicholas J A; Rubino K L; Fitzgerald D J; Pastan I; Moss B
Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions.
AIDS research and human retroviruses 1990;6(6):795-804.
1990: Kozak R W; Fitzgerald D P; Atcher R W; Goldman C K; Nelson D L; Gansow O A; Pastan I; Waldmann T A
Selective elimination in vitro of alloresponsive T cells to human transplantation antigens by toxin or radionuclide conjugated anti-IL-2 receptor (Tac) monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3417-23.
1990: Idziorek T; FitzGerald D; Pastan I
Low pH-induced changes in Pseudomonas exotoxin and its domains: increased binding of Triton X-114.
Infection and immunity 1990;58(5):1415-20.
1990: Thiebaut F; Currier S J; Whitaker J; Haugland R P; Gottesman M M; Pastan I; Willingham M C
Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(5):685-90.
1990: Willingham M C; Pastan I
A reversible multi-well chamber for incubation of cultured cells with small volumes: application to screening of hybridoma fusions using immunofluorescence microscopy.
BioTechniques 1990;8(3):320-4.
1990: Germann U A; Willingham M C; Pastan I; Gottesman M M
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus.
Biochemistry 1990;29(9):2295-303.
1990: Germann U A; Chin K V; Pastan I; Gottesman M M
Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(5):1501-7.
1990: Ford J M; Bruggemann E P; Pastan I; Gottesman M M; Hait W N
Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.
Cancer research 1990;50(6):1748-56.
1990: Raviv Y; Pollard H B; Bruggemann E P; Pastan I; Gottesman M M
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.
The Journal of biological chemistry 1990;265(7):3975-80.
1990: Chaudhary V K; Batra J K; Gallo M G; Willingham M C; FitzGerald D J; Pastan I
A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1066-70.
1990: Marino P A; Gottesman M M; Pastan I
Regulation of the multidrug resistance gene in regenerating rat liver.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(2):57-62.
1990: Goldstein L J; Fojo A T; Ueda K; Crist W; Green A; Brodeur G; Pastan I; Gottesman M M
Expression of the multidrug resistance, MDR1, gene in neuroblastomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(1):128-36.
1990: Chaudhary V K; Jinno Y; FitzGerald D; Pastan I
Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):308-12.
1990: Tomasselli A G; Hui J O; Sawyer T K; Staples D J; FitzGerald D J; Chaudhary V K; Pastan I; Heinrikson R L
Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease.
The Journal of biological chemistry 1990;265(1):408-13.
1990: Tanaka S; Currier S J; Bruggemann E P; Ueda K; Germann U A; Pastan I; Gottesman M M
Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.
Biochemical and biophysical research communications 1990;166(1):180-6.
1990: Chen C J; Clark D; Ueda K; Pastan I; Gottesman M M; Roninson I B
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
The Journal of biological chemistry 1990;265(1):506-14.
1990: Chin K V; Tanaka S; Darlington G; Pastan I; Gottesman M M
Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.
The Journal of biological chemistry 1990;265(1):221-6.
1990: Sato H; Gottesman M M; Goldstein L J; Pastan I; Block A M; Sandberg A A; Preisler H D
Expression of the multidrug resistance gene in myeloid leukemias.
Leukemia research 1990;14(1):11-21.
1990: Siegall C B; FitzGerald D J; Pastan I
Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin.
Current topics in microbiology and immunology 1990;166():63-9.
1989: Kane S E; Reinhard D H; Fordis C M; Pastan I; Gottesman M M
A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells.
Gene 1989;84(2):439-46.
1989: Siegall C B; Xu Y H; Chaudhary V K; Adhya S; Fitzgerald D; Pastan I
Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(14):2647-52.
1989: Kageyama R; Pastan I
Molecular cloning and characterization of a human DNA binding factor that represses transcription.
Cell 1989;59(5):815-25.
1989: Roberge F G; Lorberboum-Galski H; Le Hoang P; de Smet M; Chan C C; Fitzgerald D; Pastan I
Selective immunosuppression of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3498-502.
1989: Berger E A; Clouse K A; Chaudhary V K; Chakrabarti S; FitzGerald D J; Pastan I; Moss B
CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9539-43.
1989: Batra J K; Jinno Y; Chaudhary V K; Kondo T; Willingham M C; FitzGerald D J; Pastan I
Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8545-9.
1989: Ueda K; Yamano Y; Kioka N; Kakehi Y; Yoshida O; Gottesman M M; Pastan I; Komano T
Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay.
Japanese journal of cancer research : Gann 1989;80(11):1127-32.
1989: Galski H; Sullivan M; Willingham M C; Chin K V; Gottesman M M; Pastan I; Merlino G T
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.
Molecular and cellular biology 1989;9(10):4357-63.
1989: FitzGerald D; Pastan I
Targeted toxin therapy for the treatment of cancer.
Journal of the National Cancer Institute 1989;81(19):1455-63.
1989: Pirker R; FitzGerald D J; Raschack M; Frank Z; Willingham M C; Pastan I
Enhancement of the activity of immunotoxins by analogues of verapamil.
Cancer research 1989;49(17):4791-5.
1989: Kageyama R; Merlino G T; Pastan I
Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box.
The Journal of biological chemistry 1989;264(26):15508-14.
1989: Bourhis J; Goldstein L J; Riou G; Pastan I; Gottesman M M; Bénard J
Expression of a human multidrug resistance gene in ovarian carcinomas.
Cancer research 1989;49(18):5062-5.
1989: Horio M; Chin K V; Currier S J; Goldenberg S; Williams C; Pastan I; Gottesman M M; Handler J
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.
The Journal of biological chemistry 1989;264(25):14880-4.
1989: Jinno Y; Ogata M; Chaudhary V K; Willingham M C; Adhya S; FitzGerald D; Pastan I
Domain II mutants of Pseudomonas exotoxin deficient in translocation.
The Journal of biological chemistry 1989;264(27):15953-9.
1989: Pastan I; FitzGerald D
Pseudomonas exotoxin: chimeric toxins.
The Journal of biological chemistry 1989;264(26):15157-60.
1989: Bruggemann E P; Germann U A; Gottesman M M; Pastan I
Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.
The Journal of biological chemistry 1989;264(26):15483-8.
1989: Lai S L; Goldstein L J; Gottesman M M; Pastan I; Tsai C M; Johnson B E; Mulshine J L; Ihde D C; Kayser K; Gazdar A F
MDR1 gene expression in lung cancer.
Journal of the National Cancer Institute 1989;81(15):1144-50.
1989: Currier S J; Ueda K; Willingham M C; Pastan I; Gottesman M M
Deletion and insertion mutants of the multidrug transporter.
The Journal of biological chemistry 1989;264(24):14376-81.
1989: Siegall C B; Chaudhary V K; FitzGerald D J; Pastan I
Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin.
The Journal of biological chemistry 1989;264(24):14256-61.
1989: Kioka N; Tsubota J; Kakehi Y; Komano T; Gottesman M M; Pastan I; Ueda K
P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.
Biochemical and biophysical research communications 1989;162(1):224-31.
1989: Konen P L; Currier S J; Rutherford A V; Gottesman M M; Pastan I; Willingham M C
The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(7):1141-5.
1989: Pearson J W; FitzGerald D J; Willingham M C; Wiltrout R H; Pastan I; Longo D L
Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice.
Cancer research 1989;49(13):3562-7.
1989: Kanamaru H; Kakehi Y; Yoshida O; Nakanishi S; Pastan I; Gottesman M M
MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants.
Journal of the National Cancer Institute 1989;81(11):844-9.
1989: Ogata M; Chaudhary V K; FitzGerald D J; Pastan I
Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4215-9.
1989: Chaudhary V K; Queen C; Junghans R P; Waldmann T A; FitzGerald D J; Pastan I
A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.
Nature 1989;339(6223):394-7.
1989: Germann U A; Gottesman M M; Pastan I
Expression of a multidrug resistance-adenosine deaminase fusion gene.
The Journal of biological chemistry 1989;264(13):7418-24.
1989: Maekawa T; Imamoto F; Merlino G T; Pastan I; Ishii S
Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene.
The Journal of biological chemistry 1989;264(10):5488-94.
1989: Gottesman M M; Pastan I
Clinical trials of agents that reverse multidrug-resistance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(4):409-11.
1989: Banker D E; Pastan I; Gottesman M M; Herschman H R
An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes.
Journal of cellular physiology 1989;139(1):51-7.
1989: Lorberboum-Galski H; Barrett L V; Kirkman R L; Ogata M; Willingham M C; FitzGerald D J; Pastan I
Cardiac allograft survival in mice treated with IL-2-PE40.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):1008-12.
1989: Velu T J; Beguinot L; Vass W C; Zhang K; Pastan I; Lowy D R
Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay.
Journal of cellular biochemistry 1989;39(2):153-66.
1989: Nogae I; Kohno K; Kikuchi J; Kuwano M; Akiyama S; Kiue A; Suzuki K; Yoshida Y; Cornwell M M; Pastan I
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein.
Biochemical pharmacology 1989;38(3):519-27.
1989: Thiebaut F; Tsuruo T; Hamada H; Gottesman M M; Pastan I; Willingham M C
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(2):159-64.
1989: Case J P; Lorberboum-Galski H; Lafyatis R; FitzGerald D; Wilder R L; Pastan I
Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):287-91.
1989: Kurrasch R H; Rutherford A V; Rick M E; Gallo M G; Lovelace E T; Pastan I; Willingham M C
Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(1):57-67.
1989: Pirker R; Goldstein L J; Ludwig H; Linkesch W; Lechner C; Gottesman M M; Pastan I
Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.
Cancer communications 1989;1(2):141-4.
1988: Siegall C B; Chaudhary V K; FitzGerald D J; Pastan I
Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9738-42.
1988: Ogata M; Lorberboum-Galski H; FitzGerald D; Pastan I
IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4224-8.
1988: Lorberboum-Galski H; Kozak R W; Waldmann T A; Bailon P; FitzGerald D J; Pastan I
Interleukin 2 (IL2) PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor.
The Journal of biological chemistry 1988;263(35):18650-6.
1988: Yoshimoto K; Iwahana H; Yokogoshi Y; Saito S; Shiraishi M; Sekiya T; Gottesman M M; Pastan I
A polymorphic HindIII site within the human multidrug resistance gene 1 (MDR1).
Nucleic acids research 1988;16(24):11850.
1988: Richert N D; Aldwin L; Nitecki D; Gottesman M M; Pastan I
Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells.
Biochemistry 1988;27(20):7607-13.
1988: Jinno Y; Chaudhary V K; Kondo T; Adhya S; FitzGerald D J; Pastan I
Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity.
The Journal of biological chemistry 1988;263(26):13203-7.
1988: Gottesman M M; Pastan I
The multidrug transporter, a double-edged sword.
The Journal of biological chemistry 1988;263(25):12163-6.
1988: Chaudhary V K; Mizukami T; Fuerst T R; FitzGerald D J; Moss B; Pastan I; Berger E A
Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein.
Nature 1988;335(6188):369-72.
1988: Shen D W; Pastan I; Gottesman M M
In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.
Cancer research 1988;48(15):4334-9.
1988: Gallo M G; Chaudhary V K; Fitzgerald D J; Willingham M C; Pastan I
Cloning and expression of the H chain V region of antibody OVB3 that reacts with human ovarian cancer.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):1034-40.
1988: Kane S E; Troen B R; Gal S; Ueda K; Pastan I; Gottesman M M
Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.
Molecular and cellular biology 1988;8(8):3316-21.
1988: Kageyama R; Merlino G T; Pastan I
A transcription factor active on the epidermal growth factor receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5016-20.
1988: Pirker R; FitzGerald D J; Willingham M C; Pastan I
Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines.
Cancer research 1988;48(14):3919-23.
1988: Kondo T; FitzGerald D; Chaudhary V K; Adhya S; Pastan I
Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.
The Journal of biological chemistry 1988;263(19):9470-5.
1988: Amano F; Gottesman M M; Pastan I
Epidermal growth factor-dependent growth of human KB cells in a defined medium and altered growth factor requirements of KB mutants resistant to EGF-Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):502-8.
1988: Amano F; Pastan I; Gottesman M M
Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):527-32.
1988: Jinno Y; Merlino G T; Pastan I
A novel effect of EGF on mRNA stability.
Nucleic acids research 1988;16(11):4957-66.
1988: Pastan I; Gottesman M M; Ueda K; Lovelace E; Rutherford A V; Willingham M C
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4486-90.
1988: Horio M; Gottesman M M; Pastan I
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3580-4.
1988: Chaudhary V K; Xu Y H; FitzGerald D; Adhya S; Pastan I
Role of domain II of Pseudomonas exotoxin in the secretion of proteins into the periplasm and medium by Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):2939-43.
1988: Kageyama R; Merlino G T; Pastan I
Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.
The Journal of biological chemistry 1988;263(13):6329-36.
1988: Kakehi Y; Kanamaru H; Yoshida O; Ohkubo H; Nakanishi S; Gottesman M M; Pastan I
Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance.
The Journal of urology 1988;139(4):862-5.
1988: Johnson A C; Ishii S; Jinno Y; Pastan I; Merlino G T
Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.
The Journal of biological chemistry 1988;263(12):5693-9.
1988: Popescu N C; Cheng S Y; Pastan I
Chromosomal localization of the gene for a human thyroid hormone-binding protein.
American journal of human genetics 1988;42(4):560-4.
1988: Goldenthal K L; Hedman K; Chen J W; August J T; Vihko P; Pastan I; Willingham M C
Pre-lysosomal divergence of alpha 2-macroglobulin and transferrin: a kinetic study using a monoclonal antibody against a lysosomal membrane glycoprotein (LAMP-1).
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988;36(4):391-400.
1988: Lorberboum-Galski H; FitzGerald D; Chaudhary V; Adhya S; Pastan I
Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1922-6.
1988: Gottesman M M; Pastan I
Resistance to multiple chemotherapeutic agents in human cancer cells.
Trends in pharmacological sciences 1988;9(2):54-8.
1988: Akiyama S; Cornwell M M; Kuwano M; Pastan I; Gottesman M M
Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.
Molecular pharmacology 1988;33(2):144-7.
1988: Johnson A C; Garfield S H; Merlino G T; Pastan I
Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver.
Biochemical and biophysical research communications 1988;150(1):412-8.
1988: Obata T; Kitagawa S; Gong Q H; Pastan I; Cheng S Y
Thyroid hormone down-regulates p55, a thyroid hormone-binding protein that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase.
The Journal of biological chemistry 1988;263(2):782-5.
1988: Pastan I H; Gottesman M M
Molecular biology of multidrug resistance in human cells.
Important advances in oncology 1988;():3-16.
1988: FitzGerald D J; Willingham M C; Pastan I
Pseudomonas exotoxin--immunotoxins.
Cancer treatment and research 1988;37():161-73.
1987: Fojo A T; Shen D W; Mickley L A; Pastan I; Gottesman M M
Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(12):1922-7.
1987: Velu T J; Beguinot L; Vass W C; Willingham M C; Merlino G T; Pastan I; Lowy D R
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.
Science (New York, N.Y.) 1987;238(4832):1408-10.
1987: Ueda K; Pastan I; Gottesman M M
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.
The Journal of biological chemistry 1987;262(36):17432-6.
1987: Willingham M C; Richert N D; Cornwell M M; Tsuruo T; Hamada H; Gottesman M M; Pastan I H
Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(12):1451-6.
1987: Thiebaut F; Tsuruo T; Hamada H; Gottesman M M; Pastan I; Willingham M C
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7735-8.
1987: Hwang J; Richert N; Pastan I; Gottesman M M
Mutant KB cells with decreased EGF receptor expression: biochemical characterization.
Journal of cellular physiology 1987;133(1):127-34.
1987: Cryz S J; Fürer E; Sadoff J C; Germanier R; Pastan I; Willingham M C; FitzGerald D J
Use of Pseudomonas aeruginosa toxin A in the construction of conjugate vaccines and immunotoxins.
Reviews of infectious diseases 1987;9 Suppl 5():S644-9.
1987: Cheng S Y; Gong Q H; Parkison C; Robinson E A; Appella E; Merlino G T; Pastan I
The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.
The Journal of biological chemistry 1987;262(23):11221-7.
1987: Chaudhary V K; FitzGerald D J; Adhya S; Pastan I
Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(13):4538-42.
1987: Cornwell M M; Tsuruo T; Gottesman M M; Pastan I
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(1):51-4.
1987: FitzGerald D J; Willingham M C; Cardarelli C O; Hamada H; Tsuruo T; Gottesman M M; Pastan I
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4288-92.
1987: Lyall R M; Hwang J L; Cardarelli C; FitzGerald D; Akiyama S; Gottesman M M; Pastan I
Isolation of human KB cell lines resistant to epidermal growth factor-Pseudomonas exotoxin conjugates.
Cancer research 1987;47(11):2961-6.
1987: Thorgeirsson S S; Huber B E; Sorrell S; Fojo A; Pastan I; Gottesman M M
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
Science (New York, N.Y.) 1987;236(4805):1120-2.
1987: Pastan I; Gottesman M
Multiple-drug resistance in human cancer.
The New England journal of medicine 1987;316(22):1388-93.
1987: Ueda K; Cardarelli C; Gottesman M M; Pastan I
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):3004-8.
1987: Gamou S; Hunts J; Harigai H; Hirohashi S; Shimosato Y; Pastan I; Shimizu N
Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells.
Cancer research 1987;47(10):2668-73.
1987: Willingham M C; FitzGerald D J; Pastan I
Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2474-8.
1987: Kitagawa S; Obata T; Hasumura S; Pastan I; Cheng S Y
A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization.
The Journal of biological chemistry 1987;262(8):3903-8.
1987: FitzGerald D J; Bjorn M J; Ferris R J; Winkelhake J L; Frankel A E; Hamilton T C; Ozols R F; Willingham M C; Pastan I
Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.
Cancer research 1987;47(5):1407-10.
1987: Seth P; Pastan I; Willingham M C
Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase.
Journal of virology 1987;61(3):883-8.
1987: Hedman K; Goldenthal K L; Rutherford A V; Pastan I; Willingham M C
Comparison of the intracellular pathways of transferrin recycling and vesicular stomatitis virus membrane glycoprotein exocytosis by ultrastructural double-label cytochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(2):233-43.
1987: Cornwell M M; Pastan I; Gottesman M M
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
The Journal of biological chemistry 1987;262(5):2166-70.
1987: Hwang J; Fitzgerald D J; Adhya S; Pastan I
Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.
Cell 1987;48(1):129-36.
1987: Ueda K; Clark D P; Chen C J; Roninson I B; Gottesman M M; Pastan I
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.
The Journal of biological chemistry 1987;262(2):505-8.
1987: Fojo A T; Ueda K; Slamon D J; Poplack D G; Gottesman M M; Pastan I
Expression of a multidrug-resistance gene in human tumors and tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):265-9.
1987: Fojo A; Cornwell M; Cardarelli C; Clark D P; Richert N; Shen D W; Ueda K; Willingham M; Gottesman M M; Pastan I
Molecular biology of drug resistance.
Breast cancer research and treatment 1987;9(1):5-16.
1986: Hasumura S; Kitagawa S; Lovelace E; Willingham M C; Pastan I; Cheng S
Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies.
Biochemistry 1986;25(24):7881-8.
1986: Pastan I; Willingham M C; FitzGerald D J
Immunotoxins.
Cell 1986;47(5):641-8.
1986: Ueda K; Cornwell M M; Gottesman M M; Pastan I; Roninson I B; Ling V; Riordan J R
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
Biochemical and biophysical research communications 1986;141(3):956-62.
1986: Hanover J A; D'Souza P; August T; Pastan I; Willingham M C
Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit alpha 2-macroglobulin binding and uptake.
The Journal of biological chemistry 1986;261(35):16732-7.
1986: Shen D W; Fojo A; Roninson I B; Chin J E; Soffir R; Pastan I; Gottesman M M
Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
Molecular and cellular biology 1986;6(11):4039-45.
1986: Willingham M C; Cornwell M M; Cardarelli C O; Gottesman M M; Pastan I
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Cancer research 1986;46(11):5941-6.
1986: Chen C J; Chin J E; Ueda K; Clark D P; Pastan I; Gottesman M M; Roninson I B
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
Cell 1986;47(3):381-9.
1986: Hunts J; Merlino G; Pastan I; Shimizu N
Reduction of EGF receptor synthesis by antisense RNA vectors.
FEBS letters 1986;206(2):319-22.
1986: FitzGerald D J; Willingham M C; Pastan I
Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6627-30.
1986: Hedman K; Pastan I; Willingham M C
The organelles of the trans domain of the cell. Ultrastructural localization of sialoglycoconjugates using Limax flavus agglutinin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1986;34(8):1069-77.
1986: Clark A J; Beguinot L; Ishii S; Ma D P; Roe B A; Merlino G T; Pastan I
Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA.
Biochimica et biophysica acta 1986;867(4):244-51.
1986: Fojo A; Lebo R; Shimizu N; Chin J E; Roninson I B; Merlino G T; Gottesman M M; Pastan I
Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
Somatic cell and molecular genetics 1986;12(4):415-20.
1986: Hwang J; Pouyssegur J; Willingham M C; Pastan I
The role of intracellular pH in ligand internalization.
Journal of cellular physiology 1986;128(1):18-22.
1986: Cornwell M M; Gottesman M M; Pastan I H
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.
The Journal of biological chemistry 1986;261(17):7921-8.
1986: Shen D W; Cardarelli C; Hwang J; Cornwell M; Richert N; Ishii S; Pastan I; Gottesman M M
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
The Journal of biological chemistry 1986;261(17):7762-70.
1986: Roninson I B; Chin J E; Choi K G; Gros P; Housman D E; Fojo A; Shen D W; Gottesman M M; Pastan I
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4538-42.
1986: Cornwell M M; Safa A R; Felsted R L; Gottesman M M; Pastan I
Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3847-50.
1986: Ishii S; Kadonaga J T; Tjian R; Brady J N; Merlino G T; Pastan I
Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter.
Science (New York, N.Y.) 1986;232(4756):1410-3.
1986: Shen D W; Fojo A; Chin J E; Roninson I B; Richert N; Pastan I; Gottesman M M
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
Science (New York, N.Y.) 1986;232(4750):643-5.
1986: Blumenthal R; Seth P; Willingham M C; Pastan I
pH-dependent lysis of liposomes by adenovirus.
Biochemistry 1986;25(8):2231-7.
1986: Levitzki A; Rudick J; Pastan I; Vass W C; Lowy D R
Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes.
FEBS letters 1986;197(1-2):134-8.
1986: Cheng S Y; Hasumura S; Willingham M C; Pastan I
Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):947-51.
1986: Beguinot L; Werth D; Ito S; Richert N; Willingham M C; Pastan I
Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor.
The Journal of biological chemistry 1986;261(4):1801-7.
1986: Yamamoto T; Kamata N; Kawano H; Shimizu S; Kuroki T; Toyoshima K; Rikimaru K; Nomura N; Ishizaki R; Pastan I
High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.
Cancer research 1986;46(1):414-6.
1985: Hasumura S; Kitagawa S; Pastan I; Cheng S Y
Solubilization and characterization of a membrane 3, 3', 5-triiodo-L-thyronine binding protein from rat pituitary tumor GH3 cells.
Biochemical and biophysical research communications 1985;133(3):837-43.
1985: Clark A J; Ishii S; Richert N; Merlino G T; Pastan I
Epidermal growth factor regulates the expression of its own receptor.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8374-8.
1985: King C R; Kraus M H; Williams L T; Merlino G T; Pastan I H; Aaronson S A
Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs.
Nucleic acids research 1985;13(23):8477-86.
1985: Ishii S; Merlino G T; Pastan I
Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter.
Science (New York, N.Y.) 1985;230(4732):1378-81.
1985: Hanover J A; Beguinot L; Willingham M C; Pastan I H
Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.
The Journal of biological chemistry 1985;260(29):15938-45.
1985: Goldenthal K L; Pastan I; Willingham M C
Serial section analysis of clathrin-coated pits in rat liver sinusoidal endothelial cells.
Experimental cell research 1985;161(2):342-52.
1985: Seth P; Willingham M C; Pastan I
Binding of adenovirus and its external proteins to Triton X-114. Dependence on pH.
The Journal of biological chemistry 1985;260(27):14431-4.
1985: Fojo A T; Whang-Peng J; Gottesman M M; Pastan I
Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7661-5.
1985: Tyagi J S; Hirano H; Pastan I
Modulation of fibronectin gene activity in chick embryo fibroblasts transformed by a temperature-sensitive strain (ts68) of Rous sarcoma virus.
Nucleic acids research 1985;13(22):8275-84.
1985: Singh T J; Hochman J; Verna R; Chapman M; Abraham I; Pastan I H; Gottesman M M
Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase.
The Journal of biological chemistry 1985;260(26):13927-33.
1985: Pirker R; FitzGerald D J; Hamilton T C; Ozols R F; Laird W; Frankel A E; Willingham M C; Pastan I
Characterization of immunotoxins active against ovarian cancer cell lines.
The Journal of clinical investigation 1985;76(3):1261-7.
1985: Hunts J H; Shimizu N; Yamamoto T; Toyoshima K; Merlino G T; Xu Y H; Pastan I
Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA.
Somatic cell and molecular genetics 1985;11(5):477-84.
1985: Le Pendu J; Fredman P; Richter N D; Magnani J L; Willingham M C; Pastan I; Oriol R; Ginsburg V
Monoclonal antibody 101 that precipitates the glycoprotein receptor for epidermal growth factor is directed against the Y antigen, not the H type 1 antigen.
Carbohydrate research 1985;141(2):347-9.
1985: Seth P; Pastan I; Willingham M C
Adenovirus-dependent increase in cell membrane permeability.
The Journal of biological chemistry 1985;260(17):9598-602.
1985: Hunts J; Ueda M; Ozawa S; Abe O; Pastan I; Shimizu N
Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomas.
Japanese journal of cancer research : Gann 1985;76(8):663-6.
1985: Ishii S; Xu Y H; Stratton R H; Roe B A; Merlino G T; Pastan I
Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(15):4920-4.
1985: Fojo A; Akiyama S; Gottesman M M; Pastan I
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.
Cancer research 1985;45(7):3002-7.
1985: Chen J W; Murphy T L; Willingham M C; Pastan I; August J T
Identification of two lysosomal membrane glycoproteins.
The Journal of cell biology 1985;101(1):85-95.
1985: Alderson R; Pastan I; Cheng S
Characterization of the 3,3',5-triiodo-L-thyronine-binding site on plasma membranes from human placenta.
Endocrinology 1985;116(6):2621-30.
1985: Yu K T; Werth D K; Pastan I H; Czech M P
src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.
The Journal of biological chemistry 1985;260(9):5838-46.
1985: Beguinot L; Hanover J A; Ito S; Richert N D; Willingham M C; Pastan I
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2774-8.
1985: Richert N; Akiyama S; Shen D; Gottesman M M; Pastan I
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2330-3.
1985: Hanover J A; Pastan I; Willingham M C
Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts.
Experimental cell research 1985;157(1):276-81.
1985: Akiyama S; Fojo A; Hanover J A; Pastan I; Gottesman M M
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somatic cell and molecular genetics 1985;11(2):117-26.
1985: Merlino G T; Xu Y H; Richert N; Clark A J; Ishii S; Banks-Schlegel S; Pastan I
Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line.
The Journal of clinical investigation 1985;75(3):1077-9.
1985: Akiyama S; Seth P; Pirker R; FitzGerald D; Gottesman M M; Pastan I
Potentiation of cytotoxic activity of immunotoxins on cultured human cells.
Cancer research 1985;45(3):1005-7.
1985: Perrotti N; Taylor S I; Richert N D; Rapp U R; Pastan I H; Roth J
Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.
Science (New York, N.Y.) 1985;227(4688):761-3.
1985: Pirker R; FitzGerald D J; Hamilton T C; Ozols R F; Willingham M C; Pastan I
Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.
Cancer research 1985;45(2):751-7.
1985: Lyall R M; Pastan I; Willingham M C
EGF induces receptor down-regulation with no receptor recycling in KB cells.
Journal of cellular physiology 1985;122(1):166-70.
1985: Willingham M C; Pastan I
Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(1):59-64.
1985: Pastan I; Hanover J; Willingham M
The cellular entry of EGF and transferrin: a problem in intracellular sorting.
Current topics in cellular regulation 1985;26():17-25.
1985: Dickson R B; Hanover J A; Pastan I; Willingham M C
Isolation of receptosomes (endosomes) from human KB cells.
Methods in enzymology 1985;109():257-71.
1984: Seth P; Willingham M C; Pastan I
Adenovirus-dependent release of 51Cr from KB cells at an acidic pH.
The Journal of biological chemistry 1984;259(23):14350-3.
1984: Hanover J A; Willingham M C; Pastan I
Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes.
Cell 1984;39(2 Pt 1):283-93.
1984: Gottesman M M; Roth C; Vlahakis G; Pastan I
Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.
Molecular and cellular biology 1984;4(12):2639-42.
1984: Xu Y H; Richert N; Ito S; Merlino G T; Pastan I
Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7308-12.
1984: Hasumura S; Rossi B; Alderson R; Pastan I; Cheng S
Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity.
Biochemical and biophysical research communications 1984;124(3):956-62.
1984: FitzGerald D J; Waldmann T A; Willingham M C; Pastan I
Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.
The Journal of clinical investigation 1984;74(3):966-71.
1984: Seth P; Fitzgerald D J; Willingham M C; Pastan I
Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate.
Journal of virology 1984;51(3):650-5.
1984: Akiyama T; Yamada Y; Ogawara H; Richert N; Pastan I; Yamamoto T; Kasuga M
Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor.
Biochemical and biophysical research communications 1984;123(2):797-802.
1984: Akiyama S; Gottesman M M; Hanover J A; Fitzgerald D J; Willingham M C; Pastan I
Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin.
Journal of cellular physiology 1984;120(3):271-9.
1984: Seth P; Fitzgerald D; Ginsberg H; Willingham M; Pastan I
Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor.
Molecular and cellular biology 1984;4(8):1528-33.
1984: Xu Y H; Ishii S; Clark A J; Sullivan M; Wilson R K; Ma D P; Roe B A; Merlino G T; Pastan I
Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.
Nature 1984;309(5971):806-10.
1984: Goldenthal K L; Pastan I; Willingham M C
Initial steps in receptor-mediated endocytosis. The influence of temperature on the shape and distribution of plasma membrane clathrin-coated pits in cultured mammalian cells.
Experimental cell research 1984;152(2):558-64.
1984: McKeon C; Pastan I; de Crombrugghe B
DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern.
Nucleic acids research 1984;12(8):3491-502.
1984: Beguinot L; Lyall R M; Willingham M C; Pastan I
Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(8):2384-8.
1984: Werth D K; Pastan I
Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.
The Journal of biological chemistry 1984;259(8):5264-70.
1984: Merlino G T; Xu Y H; Ishii S; Clark A J; Semba K; Toyoshima K; Yamamoto T; Pastan I
Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.
Science (New York, N.Y.) 1984;224(4647):417-9.
1984: Willingham M C; Strader C D; Lefkowitz R J; Pastan I
Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes.
Experimental cell research 1984;151(2):573-7.
1984: Willingham M C; Hanover J A; Dickson R B; Pastan I
Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(1):175-9.
1984: Willingham M C; Pastan I
Endocytosis and membrane traffic in cultured cells.
Recent progress in hormone research 1984;40():569-87.
1984: Willingham M C; Pastan I
Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells.
International review of cytology 1984;92():51-92.
1984: White M F; Werth D K; Pastan I; Kahn C R
Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src.
Journal of cellular biochemistry 1984;26(3):169-79.
1983: Hanover J A; Rudick J E; Willingham M C; Pastan I
Alpha 2-macroglobulin binding to cultured fibroblasts: identification by affinity chromatography of high-affinity binding sites.
Archives of biochemistry and biophysics 1983;227(2):570-9.
1983: Ito S; Werth D K; Richert N D; Pastan I
Vinculin phosphorylation by the src kinase. Interaction of vinculin with phospholipid vesicles.
The Journal of biological chemistry 1983;258(23):14626-31.
1983: Willingham M C; Banks-Schlegel S P; Pastan I H
Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of murine sarcoma virus.
Experimental cell research 1983;149(1):141-9.
1983: Dickson R B; Hanover J A; Willingham M C; Pastan I
Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis.
Biochemistry 1983;22(24):5667-74.
1983: Werth D K; Niedel J E; Pastan I
Vinculin, a cytoskeletal substrate of protein kinase C.
The Journal of biological chemistry 1983;258(19):11423-6.
1983: Dickson R B; Beguinot L; Hanover J A; Richert N D; Willingham M C; Pastan I
Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(17):5335-9.
1983: Fredman P; Richert N D; Magnani J L; Willingham M C; Pastan I; Ginsburg V
A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen.
The Journal of biological chemistry 1983;258(18):11206-10.
1983: Roth C W; Richert N D; Pastan I; Gottesman M M
Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.
The Journal of biological chemistry 1983;258(17):10768-73.
1983: Willingham M C; Pastan I
Formation of receptosomes from plasma membrane coated pits during endocytosis: analysis by serial sections with improved membrane labeling and preservation techniques.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5617-21.
1983: Merlino G T; McKeon C; de Crombrugghe B; Pastan I
Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development.
The Journal of biological chemistry 1983;258(16):10041-8.
1983: FitzGerald D J; Trowbridge I S; Pastan I; Willingham M C
Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4134-8.
1983: Richert N D; Willingham M C; Pastan I
Epidermal growth factor receptor. Characterization of a monoclonal antibody specific for the receptor of A431 cells.
The Journal of biological chemistry 1983;258(14):8902-7.
1983: Willingham M C; Haigler H T; Fitzgerald D J; Gallo M G; Rutherford A V; Pastan I H
The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling.
Experimental cell research 1983;146(1):163-75.
1983: Tyagi J S; Hirano H; Merlino G T; Pastan I
Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.
The Journal of biological chemistry 1983;258(9):5787-93.
1983: Mato J M; Pencev D; Vasanthakumar G; Schiffmann E; Pastan I
Inhibitors of endocytosis perturb phospholipid metabolism in rabbit neutrophils and other cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(7):1929-32.
1983: Willingham M C; Wehland J; Klee C B; Richert N D; Rutherford A V; Pastan I H
Ultrastructural immunocytochemical localization of calmodulin in cultured cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(4):445-61.
1983: Schlegel R; Tralka T S; Willingham M C; Pastan I
Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site?
Cell 1983;32(2):639-46.
1983: Cheng S; Merlino G T; Pastan I H
A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates.
Nucleic acids research 1983;11(3):659-69.
1983: FitzGerald D J; Padmanabhan R; Pastan I; Willingham M C
Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis.
Cell 1983;32(2):607-17.
1983: Hirano H; Yamada Y; Sullivan M; de Crombrugghe B; Pastan I; Yamada K M
Isolation of genomic DNA clones spanning the entire fibronectin gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(1):46-50.
1983: Willingham M C; Pastan I H; Sahagian G G
Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(1):1-11.
1983: Hanover J A; Cheng S; Willingham M C; Pastan I H
alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites.
The Journal of biological chemistry 1983;258(1):370-7.
1983: Willingham M C; Pastan I H
Image intensification techniques for detection of proteins in cultured cells.
Methods in enzymology 1983;98():266-83, 635.
1983: Hanover J A; Willingham M C; Pastan I
Receptor-mediated endocytosis of alpha 2-macroglobulin: solubilization and partial purification of the fibroblast alpha 2-macroglobulin receptor.
Annals of the New York Academy of Sciences 1983;421():410-23.
1982: Dickson R B; Schlegel R; Willingham M C; Pastan I H
Involvement of Na+ and HCO-3 in receptor-mediated endocytosis of alpha 2-macroglobulin, epidermal growth factor, and vesicular stomatitis virus.
Journal of cellular physiology 1982;113(3):353-8.
1982: Tyagi J S; Merlino G T; de Crombrugghe B; Pastan I
Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.
The Journal of biological chemistry 1982;257(21):13001-8.
1982: Gorman C M; Merlino G T; Willingham M C; Pastan I; Howard B H
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(22):6777-81.
1982: Dickson R B; Schlegel R; Willingham M C; Pastan I
Binding and internalization of alpha 2-microglobulin by cultured fibroblasts. Effects of monovalent ionophores.
Experimental cell research 1982;142(1):127-40.
1982: Schlegel R; Willingham M C; Pastan I H
Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells.
Journal of virology 1982;43(3):871-5.
1982: Horiuchi R; Johnson M L; Willingham M C; Pastan I; Cheng S
Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5527-31.
1982: Via D P; Willingham M C; Pastan I; Gotto A M; Smith L C
Co-clustering and internalization of low-density lipoproteins and alpha 2-macroglobulin in human skin fibroblasts.
Experimental cell research 1982;141(1):15-22.
1982: Ito S; Richert N; Pastan I
Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4628-31.
1982: Ito S; Richert N; Pastan I
Vinculin phosphorylation by the src kinase: inhibition by chlorpromazine, imipramine and local anesthetics.
Biochemical and biophysical research communications 1982;107(2):670-5.
1982: Willingham M C; Pastan I H
Transit of epidermal growth factor through coated pits of the Golgi system.
The Journal of cell biology 1982;94(1):207-12.
1982: Dickson R B; Schlegel R; Willingham M C; Pastan I H
Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts.
Experimental cell research 1982;140(1):215-25.
1982: Merlino G T; Tyagi J S; de Crombrugghe B; Pastan I
Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts.
The Journal of biological chemistry 1982;257(12):7254-61.
1982: Richert N D; Blithe D L; Pastan I
Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors.
The Journal of biological chemistry 1982;257(12):7143-50.
1982: Blithe D L; Richert N D; Pastan I H
Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor.
The Journal of biological chemistry 1982;257(12):7135-42.
1982: McKeon C; Ohkubo H; Pastan I; de Crombrugghe B
Unusual methylation pattern of the alpha 2 (l) collagen gene.
Cell 1982;29(1):203-10.
1982: Wehland J; Willingham M C; Gallo M G; Pastan I
The morphologic pathway of exocytosis of the vesicular stomatitis virus G protein in cultured fibroblasts.
Cell 1982;28(4):831-41.
1982: Roth C W; Singh T; Pastan I; Gottesman M M
Rous sarcoma virus transformed cells are resistant to cyclic AMP.
Journal of cellular physiology 1982;111(1):42-8.
1982: Schlegel R; Dickson R B; Willingham M C; Pastan I H
Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2291-5.
1982: Horiuchi R; Cheng S Y; Willingham M; Pastan I
Inhibition of the nuclear entry of 3,3',5'-triiodo-L-thyronine by monodansylcadaverine in GH3 cells.
The Journal of biological chemistry 1982;257(6):3139-44.
1982: Davies P J; Shizuta Y; Pastan I
Purification and properties of avian and mammalian filamins.
Methods in enzymology 1982;85 Pt B():322-8.
1982: Wehland J; Willingham M C; Gallo M G; Rutherford A V; Rudick J; Dickson R B; Pastan I
Microinjection of anticlathrin antibodies into cultured fibroblasts: clathrin-coated structures in receptor-mediated endocytosis and in exocytosis.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 2():743-53.
1982: Pastan I H; Willingham M; de Crombrugghe B; Gottesman M M
Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity.
National Cancer Institute monograph 1982;60():7-15.
1982: Dickson R B; Willingham M C; Pastan I H
Receptor-mediated endocytosis of alpha 2-macroglobulin: inhibition by ionophores and stimulation by Na+ and HCO3(-).
Annals of the New York Academy of Sciences 1982;401():38-49.
1981: Willingham M C; Yamada S S; Bechtel P J; Rutherford A V; Pastan I H
Ultrastructural immunocytochemical localization of myosin in cultured fibroblastic cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(11):1289-301.
1981: Willingham M C; Pastan I H; Sahagian G G; Jourdian G W; Neufeld E F
Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6967-71.
1981: Merlino G T; Vogeli G; Yamamoto T; de Crombrugghe B; Pastan I
Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene.
The Journal of biological chemistry 1981;256(21):11251-8.
1981: Schlegel R; Willingham M; Pastan I
Monensin blocks endocytosis of vesicular stomatitis virus.
Biochemical and biophysical research communications 1981;102(3):992-8.
1981: Pastan I H; Willingham M C
Journey to the center of the cell: role of the receptosome.
Science (New York, N.Y.) 1981;214(4520):504-9.
1981: Vogeli G; Ohkubo H; Sobel M E; Yamada Y; Pastan I; de Crombrugghe B
Structure of the promoter for chicken alpha 2 type I collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5334-8.
1981: Maxfield F R; Willingham M C; Haigler H T; Dragsten P; Pastan I H
Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin.
Biochemistry 1981;20(18):5353-8.
1981: Willingham M C; Rutherford A V; Gallo M G; Wehland J; Dickson R B; Schlegel R; Pastan I H
Receptor-mediated endocytosis in cultured fibroblasts: cryptic coated pits and the formation of receptosomes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(9):1003-13.
1981: Macchia V; Caputo G; Mandato E; Rocino A; Adhya S; Pastan I
Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase.
Journal of bacteriology 1981;147(3):931-4.
1981: Dickson L A; Ninomiya Y; Bernard M P; Pesciotta D M; Parsons J; Green G; Eikenberry E F; de Crombrugghe B; Vogeli G; Pastan I; Fietzek P P; Olsen B R
The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene.
The Journal of biological chemistry 1981;256(16):8407-15.
1981: Wehland J; Willingham M C; Dickson R; Pastan I
Microinjection of anticlathrin antibodies into fibroblasts does not interfere with the receptor-mediated endocytosis of alpha2-macroglobulin.
Cell 1981;25(1):105-19.
1981: LeCam A; Gottesman M M; Pastan I
Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1981;675(1):94-100.
1981: Pretorius H T; Nandi P K; Lippoldt R E; Johnson M L; Keen J H; Pastan I; Edelhoch H
Molecular characterization of human clathrin.
Biochemistry 1981;20(10):2777-82.
1981: Willingham M C; Keen J H; Pastan I H
Ultrastructural immunocytochemical localization of clathrin in cultured fibroblasts.
Experimental cell research 1981;132(2):329-38.
1981: Sobel M R; Yamamoto T; de Crombrugghe B; Pastan I
Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts.
Biochemistry 1981;20(9):2678-84.
1981: Dickson R B; Willingham M C; Gallo M; Pastan I
Inhibition by bacitracin of high affinity binding of 125I-alpha 2M to plasma membranes.
FEBS letters 1981;126(2):265-8.
1981: Dickson R B; Willingham M C; Pastan I
alpha 2-macroglobulin adsorbed to colloidal gold: a new probe in the study of receptor-mediated endocytosis.
The Journal of cell biology 1981;89(1):29-34.
1981: Dickson R B; Nicolas J C; Willingham M C; Pastan I
Internalization of alpha 2 macroglobulin in receptosomes. Studies with monovalent electron microscopic markers.
Experimental cell research 1981;132(2):488-93.
1981: Dickson R B; Willingham M C; Pastan I
Binding and internalization of 125I-alpha 2-macroglobulin by cultured fibroblasts.
The Journal of biological chemistry 1981;256(7):3454-9.
1981: Keen J H; Willingham M C; Pastan I
Clathrin and coated vesicle proteins Immunological characterization.
The Journal of biological chemistry 1981;256(5):2538-44.
1981: Avvedimento E; Yamada Y; Lovelace E; Vogeli G; de Crombrugghe B; Pastan I
Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts.
Nucleic acids research 1981;9(5):1123-31.
1981: Willingham M C; Yamada S S; Davies P J; Rutherford A V; Gallo M G; Pastan I
Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(1):17-37.
1981: Pastan I H; Willingham M C
The internalization of insulin and other hormones by fibroblastic cells.
Diabetes care 1981;4(1):33-7.
1981: LeCam A; Nicolas J C; Singh T J; Cabral F; Pastan I; Gottesman M M
Cyclic AMP-dependent phosphorylation in intact cells and in cell-free extracts from Chinese hamster ovary cells. Studies with wild type and cyclic AMP-resistant mutants.
The Journal of biological chemistry 1981;256(2):933-41.
1981: Singh T J; Roth C; Gottesman M M; Pastan I H
Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.
The Journal of biological chemistry 1981;256(2):926-32.
1981: Fagan J B; Sobel M E; Yamada K M; de Crombrugghe B; Pastan I
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA.
The Journal of biological chemistry 1981;256(1):520-5.
1981: Maxfield F R; Willingham M C; Pastan I; Dragsten P; Cheng S Y
Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine.
Science (New York, N.Y.) 1981;211(4477):63-5.
1981: Vogeli G; Ohkubo H; Avvedimento V E; Sullivan M; Yamada Y; Mudryj M; Pastan I; de Crombrugghe B
A repetitive structure in the chick alpha 2-collagen gene.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():777-83.
1981: Pastan I H; Willingham M C
Receptor-mediated endocytosis of hormones in cultured cells.
Annual review of physiology 1981;43():239-50.
1980: Yamada Y; Avvedimento V E; Mudryj M; Ohkubo H; Vogeli G; Irani M; Pastan I; de Crombrugghe B
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp.
Cell 1980;22(3):887-92.
1980: Ohkubo H; Vogeli G; Mudryj M; Avvedimento V E; Sullivan M; Pastan I; de Crombrugghe B
Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(12):7059-63.
1980: Yamamoto T; de Crombrugghe B; Pastan I
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
Cell 1980;22(3):787-97.
1980: Avvedimento V E; Vogeli G; Yamada Y; Maizel J V; Pastan I; de Crombrugghe B
Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA.
Cell 1980;21(3):689-96.
1980: LeCam A; Gottesman M M; Pastan I
Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach.
The Journal of biological chemistry 1980;255(17):8103-8.
1980: Yamamoto T; Tyagi J S; Fagan J B; Jay G; deCrombrugghe B; Pastan I
Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones.
Journal of virology 1980;35(2):436-43.
1980: Willingham M C; Maxfield F R; Pastan I
Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1980;28(8):818-23.
1980: Willingham M C; Pastan I
The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts.
Cell 1980;21(1):67-77.
1980: Fagan J B; Pastan I; de Crombrugghe B
Sequence rearrangement and duplication of double stranded fibronectin cDNA probably occurring during cDNA synthesis by AMV reverse transcriptase and Escherichia coli DNA polymerase I.
Nucleic acids research 1980;8(13):3055-64.
1980: Milhaud P G; Davies P J; Pastan I; Gottesman M M
Regulation of transglutaminase activity in Chinese hamster ovary cells.
Biochimica et biophysica acta 1980;630(4):476-84.
1980: Cheng S Y; Maxfield F R; Robbins J; Willingham M C; Pastan I H
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3425-9.
1980: Willingham M C; Yamada S S; Pastan I
Ultrastructural localization of tubulin in cultured fibroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1980;28(5):453-61.
1980: Haigler H T; Willingham M C; Pastan I
Inhibitors of 125I-epidermal growth factor internalization.
Biochemical and biophysical research communications 1980;94(2):630-7.
1980: Davies P J; Chabay R; Zech L; Berman M; Pastan I
Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts.
Biochimica et biophysica acta 1980;629(2):282-91.
1980: Levitzki A; Willingham M; Pastan I
Evidence for participation of transglutaminase in receptor-mediated endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(5):2706-10.
1980: Vogeli G; Avvedimento E V; Sullivan M; Maizel J V; Lozano G; Adams S L; Pastan I; de Crombrugghe B
Isolation and characterization of genomic DNA coding for alpha 2 type I collagen.
Nucleic acids research 1980;8(8):1823-37.
1980: Davies P J; Wallach D; Willingham M; Pastan I; Lewis M S
Self-association of chicken gizzard filamin and heavy merofilamin.
Biochemistry 1980;19(7):1366-72.
1980: Willingham M C; Pastan I; Shih T Y; Scolnick E M
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry.
Cell 1980;19(4):1005-14.
1980: Yamamoto T; Sobel M E; Adams S L; Avvedimento V E; DiLauro R; Pastan I; de Crombrugghe B; Showalter A; Pesciotta D; Fietzek P; Olsen B
Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.
The Journal of biological chemistry 1980;255(6):2612-5.
1980: Showalter A M; Pesciotta D M; Eikenberry E F; Yamamoto T; Pastan I; DeCrombrugghe B; Fietzek P P; Olsen B R
Nucleotide sequence of a collagen cDNA-fragment coding for the carboxyl end of pro alpha 1(I)-chains.
FEBS letters 1980;111(1):61-5.
1980: Haigler H T; Maxfield F R; Willingham M C; Pastan I
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
The Journal of biological chemistry 1980;255(4):1239-41.
1980: Gottesman M M; LeCam A; Bukowski M; Pastan I
Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP.
Somatic cell genetics 1980;6(1):45-61.
1980: Yamamoto T; Jay G; Pastan I
Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):176-80.
1980: Davies P J; Davies D R; Levitzki A; Maxfield F R; Milhaud P; Willingham M C; Pastan I H
Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.
Nature 1980;283(5743):162-7.
1980: Pastan I; Jay G; Richert N; Davies P J; Willingham M
Nature and intracellular location of the product of the src gene of avian sarcoma virus.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1023-9.
1979: Maxfield F R; Davies P J; Klempner L; Willingham M C; Pastan I
Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5731-5.
1979: Richert N; Davies P J; Jay G; Pastan I
Inhibition of the transformation-specific kinase in ASV-transformed cells by N-alpha-t

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