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Ira Pastan

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Takashi Yamaguchi; Ira Pastan; Teruko Danjo; Takatoshi Hikida; Shigetada Nakanishi
Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear.
Hui Wei; Laiman Xiang; Alan S Wayne; Tapan K Bera; Oleg Chertov; Simona Colantonio; Ira Pastan
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene.
Xiu Fen Liu; David J FitzGerald; Ira Pastan
The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin.

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2013: Takashi Yamaguchi; Ira Pastan; Teruko Danjo; Takatoshi Hikida; Shigetada Nakanishi
Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear.
Neuron 2013;78(3):537-44.
2013: Hui Wei; Laiman Xiang; Alan S Wayne; Tapan K Bera; Oleg Chertov; Simona Colantonio; Ira Pastan
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene.
The Journal of biological chemistry 2013;288(17):12305-12.
2013: Xiu Fen Liu; David J FitzGerald; Ira Pastan
The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin.
Cancer research 2013;73(7):2281-8.
2013: Bryan D Choi; Patrick C Gedeon; Chien-Tsun Kuan; Duane A Mitchell; Ira Pastan; Gary E Archer; Darell D Bigner; Mingqing Cai; Luis Sanchez-Perez; John H Sampson
Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):270-5.
2013: John E Weldon; Laiman Xiang; Jingli Zhang; Dawn A Walker; Richard Beers; Raffit Hassan; Masanori Onda; Ira Pastan
A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity.
Molecular cancer therapeutics 2013;12(1):48-57.
2012: Ronit Mazor; Richard Beers; Itai Benhar; Jaime A Eberle; Kwong Y Tsang; Aaron N Vassall; David J Venzon; John E Weldon; Ira Pastan
Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):E3597-603.
2012: Jingli Zhang; Yujian Zhang; Maria Merino; Ira Pastan; Shuo Qiu; Itzhak Avital; Patricia A Fetsch; Armando C Filie; Raffit Hassan
Loss of mesothelin expression by mesothelioma cells grown in vitro determines sensitivity to anti-mesothelin immunotoxin SS1P.
Anticancer research 2012;32(12):5151-8.
2012: Ankit I Mehta; Ira Pastan; Raghu Raghavan; Divya Ajay; Darell D Bigner; Martin Brady; Bryan D Choi; Allan H Friedman; John H Sampson
Convection enhanced delivery of macromolecules for brain tumors.
Current drug discovery technologies 2012;9(4):305-10.
2012: Jichun Ma; Ira Pastan; Wai Kwan Tang; Lothar Esser; Di Xia
Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.
The Journal of biological chemistry 2012;287(40):33123-31.
2012: Shutao Wang; Vesna Zderic; Victor Frenkel; Hilary Hancock; Beom-Su Jang; Hyung-sub Kim; Sang Myung Lee; Chang H Paik; Ira Pastan; In Soo Shin; Matthew R Dreher
Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(1):218-24.
2012: Jichun Ma; Ira Pastan; Wai Kwan Tang; Lothar Esser; Di Xia
Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 8):950-3.
2012: Wenhai Liu; Masanori Onda; Raffit Hassan; Robert J Kreitman; Byungkook Lee; Laiman Xiang; Ira Pastan
Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(29):11782-7.
2012: Youngshang Pak; Ira Pastan; Yujian Zhang; Byungkook Lee
Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors.
Cancer research 2012;72(13):3143-52.
2012: Taiji Matsusaka; Fumio Niimura; Akira Nishiyama; Ira Pastan; Akihiko Saito; Akihiro Shimizu; Hiroyuki Kobori; Iekuni Ichikawa
Liver angiotensinogen is the primary source of renal angiotensin II.
Journal of the American Society of Nephrology : JASN 2012;23(7):1181-9.
2012: Robert J Kreitman; Robert Lechleider; Steven Coutre; David J Fitzgerald; Tadeusz Robak; Maryalice Stetler-Stevenson; Martin S Tallman; Wyndham H Wilson; Ira Pastan
Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(15):1822-8.
2012: Sivasubramanian Baskar; Ira Pastan; Adrian Wiestner; Wyndham H Wilson; Christoph Rader
Targeting malignant B cells with an immunotoxin against ROR1.
mAbs 2012;4(3):349-61.
2012: Hui Wei; Laiman Xiang; ALAN WAYNE; Tapan K Bera; Oleg Chertov; David J FitzGerald; Ira Pastan
Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):6898-903.
2012: Viola Biberacher; Christian Bogner; Thomas Decker; Robert J Kreitman; Christian Meyer Zum Büschenfelde; Madlene Oelsner; Ira Pastan; Christian Peschel; Burkhard Schmidt; Michaela Wagner; Ingo Ringshausen
The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.
Haematologica 2012;97(5):771-9.
2012: Beom-Su Jang; Hyung Sub Kim; Sang-Myung Lee; Ira Pastan; Faezeh Razjouyan; In Soo Shin; Shutao Wang; Zhengsheng Yao; Matthew R Dreher; Chang H Paik
Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab.
Nuclear medicine and biology 2012;39(4):472-83.
2012: Elad Sharon; Seth M Steinberg; Jingli Zhang; Jochen Gaedcke; B Michael Ghadimi; Kevin Hollevoet; Masanori Onda; Ira Pastan; Thomas Ried; Raffit Hassan
Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(4):721-5.
2012: Ronan J Kelly; Ira Pastan; Elad Sharon; Raffit Hassan
Mesothelin-targeted agents in clinical trials and in preclinical development.
Molecular cancer therapeutics 2012;11(3):517-25.
2012: Ira Pastan; Yujian Zhang
Modulating mesothelin shedding to improve therapy.
Oncotarget 2012;3(2):114-5.
2012: Tapan K Bera; Richard J Sherins; Dawn A Walker; Ira Pastan
POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells.
Biochemical and biophysical research communications 2012;417(4):1271-4.
2012: Lori L Tortorella; David Fitzgerald; Sushmita Mukherjee; Ira Pastan; Nina H Pipalia; Frederick R Maxfield
Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.
PloS one 2012;7(10):e47320.
2012: Xiu-Fen Liu; Gregory A Raciti; Tapan K Bera; Thelma Escobar; Zhaoliang Fei; Charissa Kahue; Ira Pastan
ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
PloS one 2012;7(5):e38130.
2012: Vidyalakshmi Chandramohan; Ira Pastan; John H Sampson; Darell D Bigner
Toxin-based targeted therapy for malignant brain tumors.
Clinical & developmental immunology 2012;2012():480429.
2011: John E Weldon; Ira Pastan
A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.
The FEBS journal 2011;278(23):4683-700.
2011: Margaret E Ackerman; Jennifer I Lai; Ira Pastan; K Dane Wittrup
Exploiting bias in a non-immune human antibody library to predict antigenicity.
Protein engineering, design & selection : PEDS 2011;24(11):845-53.
2011: G A Raciti; Tapan K Bera; Oksana Gavrilova; Ira Pastan
Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice.
Diabetologia 2011;54(11):2911-22.
2011: In Soo Shin; Zhengsheng Yao; Ira Pastan; Celeste Regino; Noriko Sato; Earl F Albone; Melissa F Campo; Kenneth T Cheng; Peter L Choyke; Raffit Hassan; Hyung Sub Kim; Sang-Myung Lee; Chang H Paik
Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody.
Nuclear medicine and biology 2011;38(8):1119-27.
2011: Robert J Kreitman; Ira Pastan
Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(20):6398-405.
2011: David J FitzGerald; Robert J Kreitman; ALAN WAYNE; Ira Pastan
Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.
Cancer research 2011;71(20):6300-9.
2011: Xing Du; CRYSTAL MACKALL; Laiman Xiang; Ira Pastan
Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(18):5926-34.
2011: Seiji Kawa; Robert J Kreitman; Masanori Onda; Tapan K Bera; Mitchell Ho; Ira Pastan
The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan.
mAbs 2011;3(5):479-86.
2011: Yujian Zhang; Jingli Zhang; Oleg Chertov; Raffit Hassan; Ira Pastan
Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding.
Cancer research 2011;71(17):5915-22.
2011: Koshi Murata; Shigetada Nakanishi; Tomoko Nihira; Ira Pastan; Dai Watanabe; Shuichi Yamada; Maki Imai; Kazuto Kobayashi; Hideki Mochizuki; Kensaku Mori; Masahiro Yamaguchi
Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(29):10540-57.
2011: Taiji Matsusaka; Ira Pastan; Eric Sandgren; Ayumi Shintani; Agnes B Fogo; Valentina Kon; Iekuni Ichikawa
Podocyte injury damages other podocytes.
Journal of the American Society of Nephrology : JASN 2011;22(7):1275-85.
2011: Chien-Tsun Kuan; Kenji Wakiya; Stephen T Keir; Jianjun Li; James E Herndon; Ira Pastan; Darell D Bigner
Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.
International journal of cancer. Journal international du cancer 2011;129(1):111-21.
2011: Robert J Kreitman; Evgeny Arons; Maryalice Stetler-Stevenson; David J P Fitzgerald; Wyndham H Wilson; Ira Pastan
Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia.
Leukemia & lymphoma 2011;52 Suppl 2():82-6.
2011: David J FitzGerald; Elizabeth Moskatel; Gal Ben-Josef; Roberta Traini; Tara Tendler; Ashima Sharma; Antonella Antignani; Francis Mussai; ALAN WAYNE; Robert J Kreitman; Ira Pastan
Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737.
Leukemia & lymphoma 2011;52 Suppl 2():79-81.
2011: Miriam Mossoba; Masanori Onda; Justin Taylor; Paul R Massey; Shirin Treadwell; Elad Sharon; Raffit Hassan; Ira Pastan; Daniel H Fowler
Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(11):3697-705.
2011: Ira Pastan; Masanori Onda; John Weldon; David FitzGerald; Robert J Kreitman
Immunotoxins with decreased immunogenicity and improved activity.
Leukemia & lymphoma 2011;52 Suppl 2():87-90.
2011: Mitchell Ho; Mingqian Feng; Robert J Fisher; Christoph Rader; Ira Pastan
A novel high-affinity human monoclonal antibody to mesothelin.
International journal of cancer. Journal international du cancer 2011;128(9):2020-30.
2011: Masanori Onda; Richard Beers; Laiman Xiang; Byungkook Lee; John E Weldon; Robert J Kreitman; Ira Pastan
Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5742-7.
2011: Ankit I Mehta; Ira Pastan; Raghu Raghavan; Darell D Bigner; Martin Brady; Bryan D Choi; Allan H Friedman; John H Sampson
Imaging of convection enhanced delivery of toxins in humans.
Toxins 2011;3(3):201-6.
2011: Taiji Matsusaka; Kazuto Kobayashi; Valentina Kon; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection.
American journal of physiology. Renal physiology 2011;300(3):F792-800.
2010: Raffit Hassan; Steven J Cohen; Martin Phillips; Ira Pastan; Elad Sharon; Ronan J Kelly; Charles Schweizer; Susan Weil; Daniel Laheru
Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(24):6132-8.
2010: Francis Mussai; Dario Campana; Deepa Bhojwani; Maryalice Stetler-Stevenson; Seth M Steinberg; ALAN WAYNE; Ira Pastan
Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia.
British journal of haematology 2010;150(3):352-8.
2010: Xing Du; Richard J Youle; David J FitzGerald; Ira Pastan
Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1.
Molecular and cellular biology 2010;30(14):3444-52.
2010: Raffit Hassan; Charles Schweizer; Kun F Lu; Barbara Schuler; Alan T Remaley; Susan C Weil; Ira Pastan
Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy.
Lung cancer (Amsterdam, Netherlands) 2010;68(3):455-9.
2010: Dale Ding; Charles W Kanaly; Darrell D Bigner; Thomas J Cummings; James E Herndon; Ira Pastan; Raghu Raghavan; John H Sampson
Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1.
Journal of neuro-oncology 2010;98(1):1-7.
2010: Johanna K Hansen; John E Weldon; Laiman Xiang; Richard Beers; Masanori Onda; Ira Pastan
A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(3):297-304.
2010: Neal Luther; Nai-Kong V Cheung; Eleni P Souliopoulos; Ioannis Karampelas; Ioannis Karempelas; Daniel Bassiri; Mark A Edgar; Hong-Fen Guo; Ira Pastan; Philip H Gutin; Mark M Souweidane
Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38.
Molecular cancer therapeutics 2010;9(4):1039-46.
2010: Taiji Matsusaka; Takako Asano; Fumio Niimura; Masaru Kinomura; Akihiro Shimizu; Ayumi Shintani; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.
Hypertension 2010;55(4):967-73.
2010: ALAN WAYNE; Robert J Kreitman; Harry W Findley; Glen Lew; Cynthia Delbrook; Seth M Steinberg; Maryalice Stetler-Stevenson; David J Fitzgerald; Ira Pastan
Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(6):1894-903.
2010: yujian zhang; Johanna K Hansen; Laiman Xiang; Seiji Kawa; Masanori Onda; Mitchell Ho; Raffit Hassan; Ira Pastan
A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake.
Cancer research 2010;70(3):1082-9.
2010: Edward A Berger; Ira Pastan
Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs.
PLoS pathogens 2010;6(6):e1000803.
2010: Christian Bogner; Tobias Dechow; Ingo Ringshausen; Michaela Wagner; Madlene Oelsner; Gloria Lutzny; Thomas Licht; Christian Peschel; Ira Pastan; Robert J Kreitman; Thomas Decker
Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression.
British journal of haematology 2010;148(1):99-109.
2010: Vittore Cereda; Diane J Poole; Claudia Palena; Sudipto Das; Tapan K Bera; Cinzia Remondo; James L Gulley; Philip M Arlen; Junko Yokokawa; Ira Pastan; Jeffrey Schlom; Kwong-Yok Tsang
New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2010;59(1):63-71.
2009: Robert J Kreitman; David J P Fitzgerald; Ira Pastan
Approach to the patient after relapse of hairy cell leukemia.
Leukemia & lymphoma 2009;50 Suppl 1():32-7.
2009: Xiu Fen Liu; Tapan K Bera; Lisa J Liu; Ira Pastan
A primate-specific POTE-actin fusion protein plays a role in apoptosis.
Apoptosis : an international journal on programmed cell death 2009;14(10):1237-44.
2009: Satoshi Nagata; Ira Pastan
Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics.
Advanced drug delivery reviews 2009;61(11):977-85.
2009: Robert J Kreitman; Raffit Hassan; David J FitzGerald; Ira Pastan
Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5274-9.
2009: Yoonsoo Hahn; Dong Seon Kim; Ira Pastan; Byungkook Lee
Anoctamin and transmembrane channel-like proteins are evolutionarily related.
International journal of molecular medicine 2009;24(1):51-5.
2009: Robert J Kreitman; Maryalice Stetler-Stevenson; Inger Margulies; Pierre Noel; David J P Fitzgerald; Wyndham H Wilson; Ira Pastan
Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(18):2983-90.
2009: Satoshi Nagata; Tomoko Ise; Ira Pastan
Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7518-26.
2009: Xiaodong Xiao; Mitchell Ho; Zhongyu Zhu; Ira Pastan; Dimiter S Dimitrov
Identification and characterization of fully human anti-CD22 monoclonal antibodies.
mAbs 2009;1(3):297-303.
2009: Yang Feng; Xiaodong Xiao; Zhongyu Zhu; Emily Streaker; Mitchell Ho; Ira Pastan; Dimiter S Dimitrov
A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity.
Molecular cancer therapeutics 2009;8(5):1113-8.
2009: John E Weldon; Laiman Xiang; Oleg Chertov; Inger Margulies; Robert J Kreitman; David J FitzGerald; Ira Pastan
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.
Blood 2009;113(16):3792-800.
2009: Suresh Anaganti; Johanna K Hansen; Duc Ha; Yoonsoo Hahn; Oleg Chertov; Ira Pastan; Tapan K Bera
Non-AUG translational initiation of a short CAPC transcript generating protein isoform.
Biochemical and biophysical research communications 2009;380(3):508-13.
2009: Carmine Carpenito; Michael C Milone; Raffit Hassan; Jacqueline C Simonet; Mehdi Lakhal; Megan M Suhoski; Angel Varela-Rohena; Kathleen M Haines; Daniel F Heitjan; Steven M Albelda; Richard G Carroll; James L Riley; Ira Pastan; Carl H June
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3360-5.
2009: Ralph Alderson; Robert J Kreitman; Tianling Chen; Peter Yeung; Ronald Herbst; Judy A Fox; Ira Pastan
CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):832-9.
2009: Mitchell Ho; Ira Pastan
Display and selection of scFv antibodies on HEK-293T cells.
Methods in molecular biology (Clifton, N.J.) 2009;562():99-113.
2009: Mitchell Ho; Ira Pastan
In vitro antibody affinity maturation targeting germline hotspots.
Methods in molecular biology (Clifton, N.J.) 2009;525():293-308, xiv.
2009: Mitchell Ho; Ira Pastan
Mammalian cell display for antibody engineering.
Methods in molecular biology (Clifton, N.J.) 2009;525():337-52, xiv.
2009: Bangalore K Sathyanarayana; Yoonsoo Hahn; Manish S Patankar; Ira Pastan; Byungkook Lee
Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats.
BMC structural biology 2009;9():1.
2008: yujian zhang; Ira Pastan
High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(24):7981-6.
2008: Yaeko Motoyoshi; Taiji Matsusaka; Akihiko Saito; Ira Pastan; Thomas E Willnow; Shuki Mizutani; Iekuni Ichikawa
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Kidney international 2008;74(10):1262-9.
2008: Masanori Onda; Richard Beers; Laiman Xiang; Satoshi Nagata; Qing-Cheng Wang; Ira Pastan
An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11311-6.
2008: Sudipto Das; Yoonsoo Hahn; Dawn A Walker; Satoshi Nagata; Mark C Willingham; Donna M Peehl; Tapan K Bera; Byungkook Lee; Ira Pastan
Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.
Cancer research 2008;68(15):6306-12.
2008: Xing Du; Richard Beers; David J FitzGerald; Ira Pastan
Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity.
Cancer research 2008;68(15):6300-5.
2008: Fiana Levitin; Mordechai Weiss; Yoonsoo Hahn; Omer Stern; Roger L Papke; Robert Matusik; Srinivas R Nandana; Ravit Ziv; Edward Pichinuk; Sharbel Salame; Tapan Bera; James Vincent; Byungkook Lee; Ira Pastan; Daniel H Wreschner
PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.
The Journal of biological chemistry 2008;283(24):16928-39.
2008: Malka Epel; Irit Carmi; Sharon Soueid-Baumgarten; Sang Kon Oh; Tapan Bera; Ira Pastan; Jay Berzofsky; Yoram Reiter
Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.
European journal of immunology 2008;38(6):1706-20.
2008: John H Sampson; Gamal Akabani; Gary E Archer; Mitchel S Berger; R Edward Coleman; Allan H Friedman; Henry S Friedman; Kim Greer; James E Herndon; Sandeep Kunwar; Roger E McLendon; Alison Paolino; Neil Petry; James M Provenzale; David A Reardon; Terence Z Wong; Michael R Zalutsky; Ira Pastan; Darell D Bigner
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
Neuro-oncology 2008;10(3):320-9.
2008: Peter Hafkemeyer; Ulrich Brinkmann; Elizabeth Brinkmann; Ira Pastan; Hubert E Blum; Thomas F Baumert
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
World journal of gastroenterology : WJG 2008;14(18):2810-7.
2008: Tapan K Bera; Ashley Saint Fleur; Duc Ha; Masanori Yamada; Yoomi Lee; Byungkook Lee; Yoonsoo Hahn; Dan S Kaufman; Martin Pera; Ira Pastan
Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.
Stem cells and development 2008;17(2):325-32.
2008: Alfia Khaibullina; Beom-Su Jang; Haihao Sun; Nhat Le; Sarah Yu; Victor Frenkel; Jorge Carrasquillo; Ira Pastan; King Li; Chang H Paik
Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(2):295-302.
2008: Tomoko Ise; Sudipto Das; Satoshi Nagata; Hiroshi Maeda; Yoomi Lee; Masanori Onda; Miriam R Anver; Tapan K Bera; Ira Pastan
Expression of POTE protein in human testis detected by novel monoclonal antibodies.
Biochemical and biophysical research communications 2008;365(4):603-8.
2008: Tapan K Bera; Xiu-Fen Liu; Masanori Yamada; Oksana Gavrilova; Eva Mezey; Lino Tessarollo; Miriam R Anver; Yoonsoo Hahn; Byungkook Lee; Ira Pastan
A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):270-5.
2008: Xing Du; Satoshi Nagata; Tomoko Ise; Maryalice Stetler-Stevenson; Ira Pastan
FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins.
Blood 2008;111(1):338-43.
2008: Hidenobu Ochiai; Gary E Archer; James E Herndon; Chien-Tsun Kuan; Duane A Mitchell; Darell D Bigner; Ira Pastan; John H Sampson
EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.
Cancer immunology, immunotherapy : CII 2008;57(1):115-21.
2007: Sudipto Das; Tomoko Ise; Satoshi Nagata; Hiroshi Maeda; Tapan K Bera; Ira Pastan
Palmitoylation of POTE family proteins for plasma membrane targeting.
Biochemical and biophysical research communications 2007;363(3):751-6.
2007: yujian zhang; Laiman Xiang; Raffit Hassan; Ira Pastan
Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17099-104.
2007: Daniel J Powell; Aloisio Felipe-Silva; Maria J Merino; Mojgan Ahmadzadeh; Tamika Allen; Catherine Levy; Donald E White; Sharon A Mavroukakis; Robert J Kreitman; STEVEN ROSENBERG; Ira Pastan
Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4919-28.
2007: Daniel Steinbach; Masanori Onda; Astrid Voigt; Kristin Dawczynski; Susan Wittig; Raffit Hassan; Bernd Gruhn; Ira Pastan
Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells.
European journal of haematology 2007;79(4):281-6.
2007: Raffit Hassan; Susie Bullock; Ahalya Premkumar; Robert J Kreitman; Hedy Kindler; Mark C Willingham; Ira Pastan
Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):5144-9.
2007: Xing Du; Mitchell Ho; Ira Pastan
New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(6):607-13.
2007: Daniel H Sterman; Adri Recio; Richard G Carroll; Colin T Gillespie; Andrew Haas; Anil Vachani; Veena Kapoor; Jing Sun; Richard L Hodinka; Jennifer L Brown; Michael J Corbley; Michael Parr; Mitchell Ho; Ira Pastan; Michael Machuzak; William Benedict; Xin-qiao Zhang; Elaina M Lord; Leslie A Litzky; Daniel F Heitjan; Carl H June; Larry R Kaiser; Robert H Vonderheide; Steven M Albelda; Michelle Kanther
A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4456-66.
2007: Junko Yokokawa; Tapan K Bera; Claudia Palena; Vittore Cereda; Cinzia Remondo; James L Gulley; Philip M Arlen; Ira Pastan; Jeffrey Schlom; Kwong-Yok Tsang
Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).
International journal of cancer. Journal international du cancer 2007;121(3):595-605.
2007: John H Sampson; Raghu Raghavan; Martin L Brady; James M Provenzale; James E Herndon; David Croteau; Allan H Friedman; David A Reardon; R Edward Coleman; Terence Wong; Darell D Bigner; Ira Pastan; María Inmaculada Rodríguez-Ponce; Philipp Tanner; Raj Puri; Christoph Pedain
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
Neuro-oncology 2007;9(3):343-53.
2007: David Filpula; Karen Yang; Amartya Basu; Raffit Hassan; Laiman Xiang; Zhihua Zhang; Maoliang Wang; Qing-Cheng Wang; Mitchell Ho; Richard Beers; Hong Zhao; Ping Peng; John Zhou; Xiguang Li; Gerald Petti; Ahsen Janjua; Jun Liu; Dechun Wu; Deshan Yu; Zhenfan Zhang; Clifford Longley; David FitzGerald; Robert J Kreitman; Ira Pastan
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Bioconjugate chemistry 2007;18(3):773-84.
2007: Mitchell Ho; Tapan K Bera; Mark C Willingham; Masanori Onda; Raffit Hassan; David FitzGerald; Ira Pastan
Mesothelin expression in human lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1571-5.
2007: John H Sampson; Raghu Raghavan; James M Provenzale; David Croteau; David A Reardon; R Edward Coleman; Inmaculada Rodríguez Ponce; Ira Pastan; Raj K Puri; Christoph Pedain
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin.
AJR. American journal of roentgenology 2007;188(3):703-9.
2007: Sudipto Das; Yoonsoo Hahn; Satoshi Nagata; Mark C Willingham; Tapan K Bera; Byungkook Lee; Ira Pastan
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.
Cancer research 2007;67(4):1594-601.
2007: John H Sampson; Martin L Brady; Neil Petry; David Croteau; Allan H Friedman; Henry S Friedman; Terence Wong; Darell D Bigner; Ira Pastan; Raj K Puri; Christoph Pedain
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
Neurosurgery 2007;60(2 Suppl 1):ONS89-98; discussion ONS98-9.
2007: Raffit Hassan; Wolfgang Ebel; Eric Routhier; Rina Patel; J Bradford Kline; Jingli Zhang; Qimin Chao; Sara Jacob; Howard Turchin; Lester Gibbs; Martin D Phillips; Shiyama Mudali; Christine A Iacobuzio-Donahue; Elizabeth M Jaffee; Maria Moreno; Ira Pastan; Philip M Sass; Nicholas C Nicolaides; Luigi Grasso
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.
Cancer immunity 2007;7():20.
2007: Ira Pastan; Raffit Hassan; David J FitzGerald; Robert J Kreitman
Immunotoxin treatment of cancer.
Annual review of medicine 2007;58():221-37.
2007: T Ise; Satoshi Nagata; Robert J Kreitman; Wyndham H Wilson; ALAN WAYNE; Maryalice Stetler-Stevenson; Michael Bishop; David A Scheinberg; Laura Rassenti; Thomas Kipps; R A Kyle; D F Jelinek; Ira Pastan
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma.
Leukemia 2007;21(1):169-74.
2006: Masanori Onda; Satoshi Nagata; David J FitzGerald; Richard Beers; Robert J Fisher; James J Vincent; Byungkook Lee; Michihiro Nakamura; Jaulang Hwang; Robert J Kreitman; Raffit Hassan; Ira Pastan
Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8822-34.
2006: Yoomi Lee; Tomoko Ise; Duc Ha; Ashley Saint Fleur; Yoonsoo Hahn; Xiu-Fen Liu; Satoshi Nagata; Byungkook Lee; Tapan K Bera; Ira Pastan
Evolution and expression of chimeric POTE-actin genes in the human genome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17885-90.
2006: Zhuqing Li; Sankaranarayana P Mahesh; De Fen Shen; Baoying Liu; Willie O Siu; Frank S Hwang; Qing-Cheng Wang; Chi-Chao Chan; Ira Pastan; Robert B Nussenblatt
Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma.
Cancer research 2006;66(21):10586-93.
2006: Paul E Kennedy; Tapan K Bera; Qing-Cheng Wang; Maria Gallo; Wendeline Wagner; Mark G Lewis; Edward A Berger; Ira Pastan
Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.
Journal of leukocyte biology 2006;80(5):1175-82.
2006: Robert J Kreitman; Ira Pastan
Immunotoxins in the treatment of hematologic malignancies.
Current drug targets 2006;7(10):1301-11.
2006: Robert J Kreitman; Ira Pastan
Immunotoxins in the treatment of refractory hairy cell leukemia.
Hematology/oncology clinics of North America 2006;20(5):1137-51, viii.
2006: Mitchell Ho; Masanori Onda; Qing-Cheng Wang; Raffit Hassan; Ira Pastan; Mark Lively
Mesothelin is shed from tumor cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(9):1751.
2006: Evgeny Arons; Lynn Sorbara; Mark Raffeld; Maryalice Stetler-Stevenson; Seth M Steinberg; David J Liewehr; Ira Pastan; Robert J Kreitman
Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy.
Cancer immunology, immunotherapy : CII 2006;55(9):1100-10.
2006: yujian zhang; Laiman Xiang; Raffit Hassan; Chang H Paik; Jorge Carrasquillo; Beom-Su Jang; Nhat Le; Mitchell Ho; Ira Pastan
Synergistic antitumor activity of taxol and immunotoxin SS1P in tumor-bearing mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4695-701.
2006: Masanori Onda; Satoshi Nagata; Mitchell Ho; Tapan K Bera; Raffit Hassan; H Richard Alexander; Ira Pastan
Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4225-31.
2006: Ira Pastan; Raffit Hassan; David J FitzGerald; Robert J Kreitman
Immunotoxin therapy of cancer.
Nature reviews. Cancer 2006;6(7):559-65.
2006: Mitchell Ho; Satoshi Nagata; Ira Pastan
Isolation of anti-CD22 Fv with high affinity by Fv display on human cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9637-42.
2006: Evgeny Arons; Inger Margulies; Lynn Sorbara; Mark Raffeld; Maryalice Stetler-Stevenson; Ira Pastan; Robert J Kreitman
Minimal residual disease in hairy cell leukemia patients assessed by clone-specific polymerase chain reaction.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2804-11.
2006: Daniel Steinbach; Alexander Schramm; Angelika Eggert; Masanori Onda; Kristin Dawczynski; Andreas Rump; Ira Pastan; Susann Wittig; Nadine Pfaffendorf; Astrid Voigt; Felix Zintl; Bernd Gruhn
Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2434-41.
2006: Kristi A Egland; Xiu Fen Liu; Stephen Squires; Satoshi Nagata; Yan-Gao Man; Tapan K Bera; Masanori Onda; James J Vincent; Robert L Strausberg; Byungkook Lee; Ira Pastan
High expression of a cytokeratin-associated protein in many cancers.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5929-34.
2006: Christian Korherr; Hendrik Gille; Rolf Schäfer; Kerstin Koenig-Hoffmann; Johan Dixelius; Kristi A Egland; Ira Pastan; Ulrich Brinkmann
Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4240-5.
2006: Peter Attia; Daniel J Powell; Ajay V Maker; Robert J Kreitman; Ira Pastan; STEVEN ROSENBERG
Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):208-14.
2006: Yoonsoo Hahn; Tapan K Bera; Ira Pastan; Byungkook Lee
Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.
Gene 2006;366(2):238-45.
2006: Raffit Hassan; Alan T Remaley; Maureen L Sampson; Jingli Zhang; Derrick D Cox; James F Pingpank; H Richard Alexander; Mark C Willingham; Ira Pastan; Masanori Onda
Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):447-53.
2006: Jennifer A A Gubbels; Jennifer A Belisle; Masanori Onda; Claudine Rancourt; Martine Migneault; Mitchell Ho; Tapan K Bera; Joseph Connor; Bangalore K Sathyanarayana; Byungkook Lee; Ira Pastan; Manish S Patankar
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.
Molecular cancer 2006;5(1):50.
2006: Robert J Kreitman; Ira Pastan
BL22 and lymphoid malignancies.
Best practice & research. Clinical haematology 2006;19(4):685-99.
2006: Tomoko Ise; Robert J Kreitman; Ira Pastan; Satoshi Nagata
Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(5):594-602.
2006: Tapan K Bera; Ashley Saint Fleur; Yoomi Lee; Andre Kydd; Yoonsoo Hahn; Nicholas C Popescu; Drazen Zimonjic; Byungkook Lee; Ira Pastan
POTE paralogs are induced and differentially expressed in many cancers.
Cancer research 2006;66(1):52-6.
2005: Robert J Kreitman; David R Squires; Maryalice Stetler-Stevenson; Pierre Noel; David J P FitzGerald; Wyndham H Wilson; Ira Pastan
Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6719-29.
2005: Junko Yokokawa; Claudia Palena; Philip M Arlen; Raffit Hassan; Mitchell Ho; Ira Pastan; Jeffrey Schlom; Kwong-Yok Tsang
Identification of novel human CTL epitopes and their agonist epitopes of mesothelin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6342-51.
2005: Raffit Hassan; Robert J Kreitman; Ira Pastan; Mark C Willingham
Localization of mesothelin in epithelial ovarian cancer.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2005;13(3):243-7.
2005: Masanori Onda; Mark C Willingham; Satoshi Nagata; Tapan K Bera; Richard Beers; Mitchell Ho; Raffit Hassan; Robert J Kreitman; Ira Pastan
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5840-6.
2005: Takako Asano; Fumio Niimura; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa; Taiji Matsusaka
Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis.
Journal of the American Society of Nephrology : JASN 2005;16(8):2257-62.
2005: Noriko Sato; Raffit Hassan; Axworthy Don; Karen J Wong; Sarah Yu; Louis J Theodore; Yukang Lin; Luke Park; Martin W Brechbiel; Ira Pastan; Chang H Paik; Jorge Carrasquillo
Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1201-9.
2005: Satoshi Nagata; Tomoko Ise; Masanori Onda; Kazuyasu Nakamura; Mitchell Ho; Andrew Raubitschek; Ira Pastan
Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7946-51.
2005: Mitchell Ho; Raffit Hassan; Jingli Zhang; Qing-Cheng Wang; Masanori Onda; Tapan K Bera; Ira Pastan
Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3814-20.
2005: Ira Pastan
An NIH career: from bedside to basic research and back.
The Journal of biological chemistry 2005;280(19):18553-7.
2005: Angel A Soler-García; Rangan Maitra; Vasantha Kumar; Tomoko Ise; Satoshi Nagata; Richard Beers; Tapan K Bera; Ira Pastan
The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein.
Reproduction (Cambridge, England) 2005;129(4):515-24.
2005: Taiji Matsusaka; Jing Xin; Suguri Niwa; Kazuto Kobayashi; Akira Akatsuka; Hiroomi Hashizume; Qing-Cheng Wang; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.
Journal of the American Society of Nephrology : JASN 2005;16(4):1013-23.
2005: Sookhee Bang; Satoshi Nagata; Masanori Onda; Robert J Kreitman; Ira Pastan
HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(4):1545-50.
2005: Mitchell Ho; Robert J Kreitman; Masanori Onda; Ira Pastan
In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin.
The Journal of biological chemistry 2005;280(1):607-17.
2005: John H Sampson; David A Reardon; Allan H Friedman; Henry S Friedman; R Edward Coleman; Roger E McLendon; Ira Pastan; Darell D Bigner
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
Neuro-oncology 2005;7(1):90-6.
2005: Tomoko Ise; Hiroshi Maeda; Kenneth Santora; Laiman Xiang; Robert J Kreitman; Ira Pastan; Satoshi Nagata
Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(1):87-96.
2005: Masanori Onda; Øyvind S Bruland; Ira Pastan
TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma.
Clinical orthopaedics and related research 2005;(430):142-8.
2004: Sufi Thomas; Qing Zeng; Michael W Epperly; William Gooding; Ira Pastan; Qing-Cheng Wang; Joel S Greenberger; Jennifer Rubin Grandis
Abrogation of head and neck squamous cell carcinoma growth by epidermal growth factor receptor ligand fused to pseudomonas exotoxin transforming growth factor alpha-PE38.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):7079-87.
2004: Yoonsoo Hahn; Tapan K Bera; Kristen S Gehlhaus; Ilan R Kirsch; Ira Pastan; Byungkook Lee
Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13257-61.
2004: Satoshi Nagata; Yoshito Numata; Masanori Onda; Tomoko Ise; Yoonsoo Hahn; Byungkook Lee; Ira Pastan
Rapid grouping of monoclonal antibodies based on their topographical epitopes by a label-free competitive immunoassay.
Journal of immunological methods 2004;292(1-2):141-55.
2004: Tapan K Bera; Nancy Huynh; Hiroshi Maeda; Bangalore K Sathyanarayana; Byungkook Lee; Ira Pastan
Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.
Gene 2004;337():45-53.
2004: Raffit Hassan; Tapan K Bera; Ira Pastan
Mesothelin: a new target for immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):3937-42.
2004: Hiroshi Maeda; Satoshi Nagata; Curt D Wolfgang; Gary L Bratthauer; Tapan K Bera; Ira Pastan
The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria.
The Journal of biological chemistry 2004;279(23):24561-8.
2004: Zhengsheng Yao; Meili Zhang; Kayhan Garmestani; Axworthy Don; Robert W Mallett; Alan R Fritzberg; Louis J Theodore; Paul S Plascjak; William Eckelman; Thomas Waldmann; Ira Pastan; Chang H Paik; Martin W Brechbiel; Jorge Carrasquillo
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3137-46.
2004: David J FitzGerald; Robert Kreitman; Wyndham Wilson; David Squires; Ira Pastan
Recombinant immunotoxins for treating cancer.
International journal of medical microbiology : IJMM 2004;293(7-8):577-82.
2004: SangKon Oh; Masaki Terabe; C David Pendleton; Anu Bhattacharyya; Tapan K Bera; Malka Epel; Yoram Reiter; John Phillips; W Marston Linehan; Claude Kasten-Sportes; Ira Pastan; Jay A Berzofsky
Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells.
Cancer research 2004;64(7):2610-8.
2004: Thomas Decker; Madlene Oelsner; Robert J Kreitman; Giuliana Salvatore; Qing-Cheng Wang; Ira Pastan; Christian Peschel; Thomas Licht
Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins.
Blood 2004;103(7):2718-26.
2004: Tapan K Bera; Sudipto Das; Hiroshi Maeda; Richard Beers; Curt D Wolfgang; Vasantha Kumar; Yoonsoo Hahn; Byungkook Lee; Ira Pastan
NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3059-64.
2004: Masanori Onda; Qing-Cheng Wang; Hong-fen Guo; Nai-Kong V Cheung; Ira Pastan
In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma.
Cancer research 2004;64(4):1419-24.
2004: Ira Pastan; Richard Beers; Tapan K Bera
Recombinant immunotoxins in the treatment of cancer.
Methods in molecular biology (Clifton, N.J.) 2004;248():503-18.
2004: Raffit Hassan; Juanita Williams-Gould; Thelma Watson; Lee Pai-Scherf; Ira Pastan
Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):16-8.
2003: Tapan K Bera; Yoonsoo Hahn; Byungkook Lee; Ira Pastan
TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates.
Biochemical and biophysical research communications 2003;312(4):1209-15.
2003: Amita Gupta; Masanori Onda; Ira Pastan; Sankar Adhya; Vijay K Chaudhary
High-density functional display of proteins on bacteriophage lambda.
Journal of molecular biology 2003;334(2):241-54.
2003: Hiromi Sano; Yasunobu Yasoshima; Natsuki Matsushita; Takeshi Kaneko; Kenji Kohno; Ira Pastan; Kazuto Kobayashi
Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9078-88.
2003: John H Sampson; Gamal Akabani; Gary E Archer; Darell D Bigner; Mitchel S Berger; Allan H Friedman; Henry S Friedman; James E Herndon; Sandeep Kunwar; Steve Marcus; Roger E McLendon; Alison Paolino; Kara Penne; James M Provenzale; Jennifer Quinn; David A Reardon; Jeremy Rich; Timothy T Stenzel; Sandra Tourt-Uhlig; Carol J Wikstrand; Terence Wong; Roger Williams; Fan Yuan; Michael R Zalutsky; Ira Pastan
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.
Journal of neuro-oncology 2003;65(1):27-35.
2003: Satoshi Nagata; Giuliana Salvatore; Ira Pastan
DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins.
Journal of immunological methods 2003;280(1-2):59-72.
2003: Wing-Shing Cheng; Valeria Giandomenico; Ira Pastan; Magnus Essand
Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter.
Endocrinology 2003;144(8):3433-40.
2003: Takeshi Soda; Ryo Nakashima; Dai Watanabe; Kazunori Nakajima; Ira Pastan; Shigetada Nakanishi
Segregation and coactivation of developing neocortical layer 1 neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(15):6272-9.
2003: Pär Olsson; Akira Motegi; Tapan K Bera; Byungkook Lee; Ira Pastan
PRAC2: a new gene expressed in human prostate and prostate cancer.
The Prostate 2003;56(2):123-30.
2003: Yasuji Kitabatake; Tsutomu Hikida; Dai Watanabe; Ira Pastan; Shigetada Nakanishi
Impairment of reward-related learning by cholinergic cell ablation in the striatum.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7965-70.
2003: Tsutomu Hikida; Yasuji Kitabatake; Ira Pastan; Shigetada Nakanishi
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6169-73.
2003: Isabelle H Lelong-Rebel; Gérard Rebel; Carol O Cardarelli; Ira Pastan; Michael M Gottesman
Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells.
Anticancer research 2003;23(3B):2363-75.
2003: Ira Pastan
Immunotoxins containing Pseudomonas exotoxin A: a short history.
Cancer immunology, immunotherapy : CII 2003;52(5):338-41.
2003: Rangan Maitra; Dmitry N Grigoryev; Tapan K Bera; Ira Pastan; Byungkook Lee
Cloning, molecular characterization, and expression analysis of Copine 8.
Biochemical and biophysical research communications 2003;303(3):842-7.
2003: Robert J Kreitman; Ira Pastan
Immunobiological treatments of hairy-cell leukaemia.
Best practice & research. Clinical haematology 2003;16(1):117-33.
2003: Masanori Onda; James J Vincent; Byungkook Lee; Ira Pastan
Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules.
Bioconjugate chemistry 2003;14(2):480-7.
2003: Kristi A Egland; James J Vincent; Robert L Strausberg; Byungkook Lee; Ira Pastan
Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1099-104.
2002: Tapan K Bera; Drazen Zimonjic; Nicholas C Popescu; Bangalore K Sathyanarayana; Vasantha Kumar; Byungkook Lee; Ira Pastan
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16975-80.
2002: Tomoo Hirano; Dai Watanabe; Shin-Ya Kawaguchi; Ira Pastan; Shigetada Nakanishi
Roles of inhibitory interneurons in the cerebellar cortex.
Annals of the New York Academy of Sciences 2002;978():405-12.
2002: Insook Kim; Hisataka Kobayashi; Tae M Yoo; Meyong-kon Kim; Nhat Le; Eui-sik Han; Qing-Cheng Wang; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.
Nuclear medicine and biology 2002;29(8):795-801.
2002: Raffit Hassan; Megan R Lerner; Doris M Benbrook; Stan A Lightfoot; Daniel J Brackett; Qing-Cheng Wang; Ira Pastan
Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3520-6.
2002: Zhengsheng Yao; Meili Zhang; Axworthy Don; Karen J Wong; Kayhan Garmestani; Luke Park; Chang W Park; Robert W Mallett; Louis J Theodore; Eric K Yau; Thomas Waldmann; Martin W Brechbiel; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Cancer research 2002;62(20):5755-60.
2002: Louise McHugh; Stella Hu; B K Lee; Kenneth Santora; Paul E Kennedy; Edward A Berger; Ira Pastan; Dean H Hamer
Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis.
The Journal of biological chemistry 2002;277(37):34383-90.
2002: Ira Pastan; Robert J Kreitman
Immunotoxins in cancer therapy.
Current opinion in investigational drugs (London, England : 2000) 2002;3(7):1089-91.
2002: Satoshi Nagata; Masanori Onda; Yoshito Numata; Kenneth Santora; Richard Beers; Robert J Kreitman; Ira Pastan
Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2345-55.
2002: Giuliana Salvatore; Satoshi Nagata; Marc Billaud; Massimo Santoro; Giancarlo Vecchio; Ira Pastan
Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase.
Biochemical and biophysical research communications 2002;294(4):813-7.
2002: Dominic Fan; Seiji Yano; Hisashi Shinohara; Carmen C Solorzano; Melissa Van Arsdall; Corazon D Bucana; Sen Pathak; Ewa Kruzel; Roy S Herbst; Amir Onn; Jennifer S Roach; Masanori Onda; Qing-Cheng Wang; Ira Pastan; Isaiah J Fidler
Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.
Molecular cancer therapeutics 2002;1(8):595-600.
2002: Tapan K Bera; Carlo Iavarone; Vasantha Kumar; Sanghyuk Lee; Byungkook Lee; Ira Pastan
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6997-7002.
2002: Kristi A Egland; Vasantha Kumar; Paul H Duray; Ira Pastan
Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers.
Molecular cancer therapeutics 2002;1(7):441-50.
2002: Masaaki Hazama; Dai Watanabe; Misao Suzuki; Akira Mizoguchi; Ira Pastan; Shigetada Nakanishi
Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice.
Brain research. Molecular brain research 2002;100(1-2):53-66.
2002: Giuliana Salvatore; Richard Beers; Inger Margulies; Robert J Kreitman; Ira Pastan
Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):995-1002.
2002: Tapan K Bera; Rangan Maitra; Carlo Iavarone; Giuliana Salvatore; Vasantha Kumar; James J Vincent; Bangalore K Sathyanarayana; Paul H Duray; B K Lee; Ira Pastan
PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3058-63.
2002: Carlo Iavarone; Curt D Wolfgang; Vasantha Kumar; Paul H Duray; Mark C Willingham; Ira Pastan; Tapan K Bera
PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.
Molecular cancer therapeutics 2002;1(5):329-35.
2002: Thomas Decker; Susanne Hipp; Robert J Kreitman; Ira Pastan; Christian Peschel; Thomas Licht
Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides.
Blood 2002;99(4):1320-6.
2002: Hisashi Shinohara; Shinsho Morita; Masaru Kawai; Akiko Miyamoto; Toyooki Sonoda; Ira Pastan; Nobuhiko Tanigawa
Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin.
The Journal of surgical research 2002;102(2):169-77.
2002: Bharat H Joshi; Pamela Leland; J Silber; Robert J Kreitman; Ira Pastan; M Berger; Raj K Puri
IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein.
British journal of cancer 2002;86(2):285-91.
2001: J H Park; H W Kwon; H K Chung; Ik-Hwan Kim; Kwangseog Ahn; Eui-Ju Choi; Ira Pastan; M Choe
A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains.
Molecules and cells 2001;12(3):398-402.
2001: Tapan K Bera; Juanita Williams-Gould; Richard Beers; Partha S Chowdhury; Ira Pastan
Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer.
Molecular cancer therapeutics 2001;1(2):79-84.
2001: Curt D Wolfgang; M Essand; Byungkook Lee; Ira Pastan
T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin.
Cancer research 2001;61(22):8122-6.
2001: Tsutomu Hikida; Shuji Kaneko; T Isobe; Yasuji Kitabatake; Dai Watanabe; Ira Pastan; Shigetada Nakanishi
Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13351-4.
2001: Tapan K Bera; J Bera; Ulrich Brinkmann; Lino Tessarollo; Ira Pastan
Cse1l is essential for early embryonic growth and development.
Molecular and cellular biology 2001;21(20):7020-4.
2001: Pär Olsson; Tapan K Bera; M Essand; V Kumar; Paul H Duray; J Vincent; Byungkook Lee; Ira Pastan
GDEP, a new gene differentially expressed in normal prostate and prostate cancer.
The Prostate 2001;48(4):231-41.
2001: T Kobayashi; Y Kida; T Kaneko; Ira Pastan; Kazuto Kobayashi
Efficient ablation by immunotoxin-mediated cell targeting of the cell types that express human interleukin-2 receptor depending on the internal ribosome entry site.
The journal of gene medicine 2001;3(5):505-10.
2001: Tapan K Bera; S Lee; G Salvatore; B Lee; Ira Pastan
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.
Molecular medicine (Cambridge, Mass.) 2001;7(8):509-16.
2001: Robert J Kreitman; Wyndham H Wilson; K Bergeron; M Raggio; Maryalice Stetler-Stevenson; David J FitzGerald; Ira Pastan
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia.
The New England journal of medicine 2001;345(4):241-7.
2001: Masanori Onda; Satoshi Nagata; Y Tsutsumi; James J Vincent; Q Wang ; Robert J Kreitman; Byungkook Lee; Ira Pastan
Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
Cancer research 2001;61(13):5070-7.
2001: Henk Rozemuller; Partha S Chowdhury; Ira Pastan; Robert J Kreitman
Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 2001;92(6):861-70.
2001: K Yoshida; Dai Watanabe; Hiroshi Ishikane; M Tachibana; Ira Pastan; Shigetada Nakanishi
A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.
Neuron 2001;30(3):771-80.
2001: Caroline G L Lee; W D Vieira; Ira Pastan; Michael M Gottesman
An episomally maintained MDR1 gene for gene therapy.
Human gene therapy 2001;12(8):945-53.
2001: Kayhan Garmestani; Zhengsheng Yao; Meili Zhang; K Wong; Chang W Park; Ira Pastan; Jorge Carrasquillo; Martin W Brechbiel
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.
Nuclear medicine and biology 2001;28(4):409-18.
2001: X F Liu; Pär Olsson; Curt D Wolfgang; Tapan K Bera; Paul H Duray; Byungkook Lee; Ira Pastan
PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon.
The Prostate 2001;47(2):125-31.
2001: Axel Wellmann; P Flemming; Peter Behrens; K Wuppermann; H Lang; K Oldhafer; Ira Pastan; Ulrich Brinkmann
High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression.
International journal of molecular medicine 2001;7(5):489-94.
2001: N Yerushalmi; A Keppler-Hafkemeyer; George Vasmatzis; X F Liu; Pär Olsson; Tapan K Bera; Paul H Duray; Byungkook Lee; Ira Pastan
ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues.
Gene 2001;265(1-2):55-60.
2001: Jonathan R Moll; Sergei B Ruvinov; Ira Pastan; Charles Vinson
Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10(-15) M.
Protein science : a publication of the Protein Society 2001;10(3):649-55.
2001: Masanori Onda; T Olafsen; Y Tsutsumi; O S Bruland; Ira Pastan
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2001;24(2):144-50.
2001: Partha S Chowdhury; M Gallo; Ira Pastan
Generation of high titer antisera in rabbits by DNA immunization.
Journal of immunological methods 2001;249(1-2):147-54.
2000: Masanori Onda; Mark C Willingham; Qing-Cheng Wang; Robert J Kreitman; Y Tsutsumi; Satoshi Nagata; Ira Pastan
Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7150-6.
2000: Chien-Tsun Kuan; Carol J Wikstrand; Gary E Archer; R Beers; Ira Pastan; Michael R Zalutsky; Darell D Bigner
Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv.
International journal of cancer. Journal international du cancer 2000;88(6):962-9.
2000: Hisashi Shinohara; Dominic Fan; S Ozawa; Seiji Yano; M Van Arsdell; Jaye L Viner; Richard Beers; Ira Pastan; Isaiah J Fidler
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
International journal of oncology 2000;17(4):643-51.
2000: X F Liu; Lee Helman; Choh Yeung; Tapan K Bera; Byungkook Lee; Ira Pastan
XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.
Cancer research 2000;60(17):4752-5.
2000: Curt D Wolfgang; M Essand; James J Vincent; Byungkook Lee; Ira Pastan
TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9437-42.
2000: Shuji Kaneko; Tsutomu Hikida; Dai Watanabe; H Ichinose; Toshiharu Nagatsu; R J Kreitman; Ira Pastan; Shigetada Nakanishi
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Science (New York, N.Y.) 2000;289(5479):633-7.
2000: Y Tsutsumi; Masanori Onda; Satoshi Nagata; Byungkook Lee; Robert J Kreitman; Ira Pastan
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8548-53.
2000: Raffit Hassan; Jaye L Viner; Qing-Cheng Wang; Inger Margulies; Robert J Kreitman; Ira Pastan
Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):473-9.
2000: Richard Beers; Partha S Chowdhury; D Bigner; Ira Pastan
Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2835-43.
2000: A Keppler-Hafkemeyer; Robert J Kreitman; Ira Pastan
Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies.
International journal of cancer. Journal international du cancer 2000;87(1):86-94.
2000: R W Rand; R J Kreitman; N Patronas; F Varricchio; Ira Pastan; R K Puri
Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2157-65.
2000: C L Booth; Lukasz Pulaski; Michael M Gottesman; Ira Pastan
Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.
Biochemistry 2000;39(18):5518-26.
2000: Lee Pai-Scherf; Jorge Carrasquillo; Chang H Paik; Otto A Gansow; Millie Whatley; D Pearson; KO Webber; Michael Hamilton; Carmen J Allegra; Martin W Brechbiel; Mark C Willingham; Ira Pastan
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1720-30.
2000: Robert J Kreitman; Inger Margulies; Maryalice Stetler-Stevenson; Qing-Cheng Wang; David J FitzGerald; Ira Pastan
Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1476-87.
2000: Hisataka Kobayashi; C H Kao; Robert J Kreitman; Nhat Le; Meyoung-Kon Kim; Martin W Brechbiel; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):755-62.
2000: Robert J Kreitman; Wyndham H Wilson; Jeffrey D White; Maryalice Stetler-Stevenson; Elaine S Jaffe; S Giardina; Thomas Waldmann; Ira Pastan
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(8):1622-36.
2000: Tapan K Bera; Ira Pastan
Mesothelin is not required for normal mouse development or reproduction.
Molecular and cellular biology 2000;20(8):2902-6.
2000: Ding-Wu Shen; S Goldenberg; Ira Pastan; Michael M Gottesman
Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake.
Journal of cellular physiology 2000;183(1):108-16.
2000: Pamela Leland; J Taguchi; Syed R Husain; Robert J Kreitman; Ira Pastan; Raj K Puri
Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo.
Molecular medicine (Cambridge, Mass.) 2000;6(3):165-78.
2000: P Hafkemeyer; Thomas Licht; Ira Pastan; Michael M Gottesman
Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers.
Human gene therapy 2000;11(4):555-65.
2000: Harris Goldstein; Massimo Pettoello-Mantovani; T K Bera; Ira Pastan; Edward A Berger
Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice.
The Journal of infectious diseases 2000;181(3):921-6.
2000: C G Lee; M Ramachandra; K T Jeang; Malcolm Martin; Ira Pastan; Michael M Gottesman
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(3):516-22.
2000: Angela Mariano; Angelina Di Carlo; Ira Pastan; Vincenzo Macchia
Analysis of glycoproteins in cancers and normal tissues reactive with monoclonal antibodies B3 and B1.
International journal of oncology 2000;16(3):549-53.
2000: Thomas Licht; S K Goldenberg; Wilfred D Vieira; Michael M Gottesman; Ira Pastan
Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice.
Gene therapy 2000;7(4):348-58.
2000: N Yerushalmi; Ulrich Brinkmann; E Brinkmann; LH Pai; Ira Pastan
Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes.
Cancer gene therapy 2000;7(1):91-6.
1999: Partha S Chowdhury; Ira Pastan
Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations.
Journal of immunological methods 1999;231(1-2):83-91.
1999: H Kobayashi; Yutaka Tagaya; E S Han; I S Kim; N Le; Chang H Paik; Ira Pastan; D L Nelson; Thomas Waldmann; Jorge Carrasquillo
Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.
Cytokine 1999;11(12):1065-75.
1999: Masanori Onda; Robert J Kreitman; George Vasmatzis; Byungkook Lee; Ira Pastan
Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6072-7.
1999: Robert J Kreitman; Wyndham H Wilson; D Robbins; Inger Margulies; Maryalice Stetler-Stevenson; Thomas Waldmann; Ira Pastan
Responses in refractory hairy cell leukemia to a recombinant immunotoxin.
Blood 1999;94(10):3340-8.
1999: X F Liu; M Essand; George Vasmatzis; Byungkook Lee; Ira Pastan
Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing.
Biochemical and biophysical research communications 1999;264(3):833-9.
1999: E Adobati; A Zacchetti; ME Perico; Fausto Cremonesi; Guido Rasi; P S Vallebona; Muriel A Hagenaars; Peter Kuppen; Ira Pastan; L Panza; G Russo; MI Colnaghi; Silvana Canevari
Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: implication for the development of human-derived cancer vaccines.
The Histochemical journal 1999;31(11):729-37.
1999: Y Zhou; Michael M Gottesman; Ira Pastan
Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2).
Molecular pharmacology 1999;56(5):997-1004.
1999: CA Hrycyna; M Ramachandra; ursula germann; P W Cheng; Ira Pastan; Michael M Gottesman
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Biochemistry 1999;38(42):13887-99.
1999: Gary E Archer; John H Sampson; I A Lorimer; Roger E McLendon; Chien-Tsun Kuan; Allan H Friedman; Henry S Friedman; Ira Pastan; Darell D Bigner
Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2646-52.
1999: Lee Pai-Scherf; J Villa; D Pearson; T Watson; Edison Liu; Mark C Willingham; Ira Pastan
Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2311-5.
1999: Thomas Licht; JM Aran; S K Goldenberg; Wilfred D Vieira; Michael M Gottesman; Ira Pastan
Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein.
Human gene therapy 1999;10(13):2173-85.
1999: Tapan K Bera; Jaye L Viner; E Brinkmann; Ira Pastan
Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2.
Cancer research 1999;59(16):4018-22.
1999: M Essand; George Vasmatzis; Ulrich Brinkmann; Paul H Duray; Byungkook Lee; Ira Pastan
High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9287-92.
1999: Hisataka Kobayashi; BF Sun; Tae M Yoo; Nhat Le; Meyoung-Kon Kim; Chang H Paik; Ira Pastan; Thomas Waldmann; Jorge Carrasquillo
Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(8):1381-91.
1999: Kenneth H Cowan; Jeffrey A Moscow; H Huang; Jo Anne Zujewski; Joyce A O'Shaughnessy; Brian P Sorrentino; Kenneth Hines; Charles Carter; E Schneider; Georgia Cusack; MH Noone; Cynthia Dunbar; S Steinberg; Wyndham Wilson; Barry Goldspiel; Elizabeth J Read; Susan F Leitman; Kevin T McDonagh; Catherine Chow; Andrea Abati; Y Chiang; Y N Chang; Michael M Gottesman; Ira Pastan; Arthur W Nienhuis
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1619-28.
1999: Syed R Husain; Robert J Kreitman; Ira Pastan; Raj K Puri
Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.
Nature medicine 1999;5(7):817-22.
1999: Jeffrey A Moscow; H Huang; Charles Carter; Kenneth Hines; Jo Anne Zujewski; Georgia Cusack; Catherine Chow; David Venzon; Brian P Sorrentino; Y Chiang; Barry Goldspiel; Susan F Leitman; Elizabeth J Read; Andrea Abati; Michael M Gottesman; Ira Pastan; Stephanie Sellers; Cynthia Dunbar; Kenneth H Cowan
Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.
Blood 1999;94(1):52-61.
1999: Y Zhou; Michael M Gottesman; Ira Pastan
The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2.
Archives of biochemistry and biophysics 1999;367(1):74-80.
1999: Chien-Tsun Kuan; Craig J Reist; CF Foulon; I A Lorimer; Gary E Archer; Charles N Pegram; Ira Pastan; Michael R Zalutsky; Darell D Bigner
125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1539-49.
1999: Partha S Chowdhury; Ira Pastan
Improving antibody affinity by mimicking somatic hypermutation in vitro.
Nature biotechnology 1999;17(6):568-72.
1999: S Dey; P Hafkemeyer; Ira Pastan; Michael M Gottesman
A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.
Biochemistry 1999;38(20):6630-9.
1999: Ulrich Brinkmann; E Brinkmann; Tapan K Bera; Axel Wellmann; Ira Pastan
Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.
Genomics 1999;58(1):41-9.
1999: IS Kim; Tae M Yoo; Hisataka Kobayashi; Meyoung-Kon Kim; Nhat Le; Qing-Cheng Wang; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.
Bioconjugate chemistry 1999;10(3):447-53.
1999: P Hafkemeyer; Ulrich Brinkmann; Michael M Gottesman; Ira Pastan
Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo.
Human gene therapy 1999;10(6):923-34.
1999: Ulrich Brinkmann; George Vasmatzis; Byungkook Lee; Ira Pastan
Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.
Cancer research 1999;59(7):1445-8.
1999: Robert J Kreitman; Qing-Cheng Wang; David J FitzGerald; Ira Pastan
Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys.
International journal of cancer. Journal international du cancer 1999;81(1):148-55.
1999: Karlheinz Friedrich; S Wietek; A Lischke; Claudia Wellbrock; R J Kreitman; Ira Pastan; Walter Sebald
A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors.
Analytical biochemistry 1999;268(2):179-86.
1999: Q Lou; Ira Pastan
A Lewis(y) epitope mimicking peptide induces anti-Lewis(y) immune responses in rabbits and mice.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):252-60.
1999: B Jwang; N Yerushalmi; Robert J Kreitman; J Engberg; Ira Pastan
An scFv phage clone that binds to human beta2-microglobulin.
Immunotechnology : an international journal of immunological engineering 1999;4(3-4):231-6.
1999: R Hassan; C Wu; M W Brechbiel; Inger Margulies; Robert J Kreitman; Ira Pastan
111Indium-labeled monoclonal antibody K1: biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin.
International journal of cancer. Journal international du cancer 1999;80(4):559-63.
1999: Y Zhou; Michael M Gottesman; Ira Pastan
Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase.
Molecular and cellular biology 1999;19(2):1450-9.
1999: JM Aran; Ira Pastan; Michael M Gottesman
Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy.
Advances in pharmacology (San Diego, Calif.) 1999;46():1-42.
1999: Suresh V Ambudkar; S Dey; CA Hrycyna; M Ramachandra; Ira Pastan; Michael M Gottesman
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annual review of pharmacology and toxicology 1999;39():361-98.
1999: David T Harris; Debbie Sakiestewa; C Lyons; R J Kreitman; Ira Pastan
Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor.
Bone marrow transplantation 1999;23(2):137-44.
1998: Yoram Reiter; Ira Pastan
Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis.
Trends in biotechnology 1998;16(12):513-20.
1998: A Keppler-Hafkemeyer; Ulrich Brinkmann; Ira Pastan
Role of caspases in immunotoxin-induced apoptosis of cancer cells.
Biochemistry 1998;37(48):16934-42.
1998: P Hafkemeyer; S Dey; Suresh V Ambudkar; CA Hrycyna; Ira Pastan; Michael M Gottesman
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.
Biochemistry 1998;37(46):16400-9.
1998: Tapan K Bera; Ira Pastan
Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability.
Bioconjugate chemistry 1998;9(6):736-43.
1998: G Russ; M Ramachandra; CA Hrycyna; Michael M Gottesman; Ira Pastan; Jack R Bennink; jon yewdell
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer research 1998;58(20):4688-93.
1998: Dai Watanabe; H Inokawa; K Hashimoto; N Suzuki; M Kano; R Shigemoto; T Hirano; K Toyama; Shuji Kaneko; M Yokoi; Koki Moriyoshi; Misao Suzuki; K Kobayashi; Toshiharu Nagatsu; R J Kreitman; Ira Pastan; Shigetada Nakanishi
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Cell 1998;95(1):17-27.
1998: T Shoshani; S Zhang; S Dey; Ira Pastan; Michael M Gottesman
Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.
Molecular pharmacology 1998;54(4):623-30.
1998: U Scherf; Petr Kalab; Mary Dasso; Ira Pastan; Ulrich Brinkmann
The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS.
Biochemical and biophysical research communications 1998;250(3):623-8.
1998: CA Hrycyna; L E Airan; ursula germann; Suresh V Ambudkar; Ira Pastan; Michael M Gottesman
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Biochemistry 1998;37(39):13660-73.
1998: Edward A Berger; Bernard Moss; Ira Pastan
Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11511-3.
1998: Partha S Chowdhury; George Vasmatzis; Richard Beers; Byungkook Lee; Ira Pastan
Improved stability and yield of a Fv-toxin fusion protein by computer design and protein engineering of the Fv.
Journal of molecular biology 1998;281(5):917-28.
1998: Ulrich Brinkmann; George Vasmatzis; Byungkook Lee; N Yerushalmi; M Essand; Ira Pastan
PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10757-62.
1998: Tapan K Bera; Masanori Onda; Ulrich Brinkmann; Ira Pastan
A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
Journal of molecular biology 1998;281(3):475-83.
1998: Syed R Husain; N Behari; Robert J Kreitman; Ira Pastan; Raj K Puri
Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.
Cancer research 1998;58(16):3649-53.
1998: Saraswathy Seetharam; Edwardine Nodzenski; Michael A Beckett; Ruth Heimann; A Cha; I Margulies; Ira Pastan; Donald Kufe; Ralph R Weichselbaum
Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein.
Cancer research 1998;58(15):3215-20.
1998: Zoran Culig; Anton Hittmair; Alfred Hobisch; Georg Bartsch; Helmut Klocker; L H Pai; Ira Pastan
Expression of Lewis carbohydrate antigens in metastatic lesions from human prostatic carcinoma.
The Prostate 1998;36(3):162-7.
1998: CA Hrycyna; M Ramachandra; Suresh V Ambudkar; Y H Ko; Peter L Pedersen; Ira Pastan; Michael M Gottesman
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
The Journal of biological chemistry 1998;273(27):16631-4.
1998: M Essand; Ira Pastan
Anti-prostate immunotoxins: cytotoxicity of E4 antibody-Pseudomonas exotoxin constructs.
International journal of cancer. Journal international du cancer 1998;77(1):123-7.
1998: JM Aran; Michael M Gottesman; Ira Pastan
Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein.
Cancer gene therapy 1998;5(4):195-206.
1998: Jorge Carrasquillo; L Lang; Millie Whatley; P Herscovitch; Qing-Cheng Wang; Ira Pastan; William Eckelman
Aminosyn II effectively blocks renal uptake of 18F-labeled anti-tac disulfide-stabilized Fv.
Cancer research 1998;58(12):2612-7.
1998: Tapan K Bera; Paul E Kennedy; Edward A Berger; C F Barbas; Ira Pastan
Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein.
Molecular medicine (Cambridge, Mass.) 1998;4(6):384-91.
1998: Sandra E Kleiman; Ira Pastan; Jennifer M Puck; Michael M Gottesman
Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency.
Gene therapy 1998;5(5):671-6.
1998: Hisataka Kobayashi; Eui-sik Han; IS Kim; Nhat Le; V Rajagopal; Robert J Kreitman; Ira Pastan; Chang H Paik; Jorge Carrasquillo
Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment.
Nuclear medicine and biology 1998;25(4):387-93.
1998: Orna Almog; I Benhar; G Vasmatzis; Maria Tordova; B Lee; Ira Pastan; Gary L Gilliland
Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond.
Proteins 1998;31(2):128-38.
1998: Hisataka Kobayashi; Chuanchu Wu; Tae M Yoo; BF Sun; D Drumm; Ira Pastan; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Martin W Brechbiel
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(5):829-36.
1998: M Ramachandra; Suresh V Ambudkar; D Chen; CA Hrycyna; S Dey; Michael M Gottesman; Ira Pastan
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.
Biochemistry 1998;37(14):5010-9.
1998: Hisataka Kobayashi; BF Sun; Eui-sik Han; Meyoung-Kon Kim; Nhat Le; Qing-Cheng Wang; David L Nelson; Ira Pastan; Thomas Waldmann; Chang H Paik; Jorge Carrasquillo
Epitope blocking: positive and negative effects on the biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment of two antibodies against different epitopes of the circulating antigen.
Japanese journal of cancer research : Gann 1998;89(4):436-44.
1998: D Yang; C T Kuan; J Payne; A Kihara; A Murray; Ling Mei Wang; M Alimandi; JH Pierce; Ira Pastan; Marc Lippman
Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):993-1004.
1998: C G Lee; Michael M Gottesman; Carol Cardarelli; M Ramachandra; Kuan-Teh Jeang; Suresh V Ambudkar; Ira Pastan; S Dey
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
Biochemistry 1998;37(11):3594-601.
1998: Robert J Kreitman; Ira Pastan
Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses.
Cancer research 1998;58(5):968-75.
1998: Y Zhou; J Aran; Michael M Gottesman; Ira Pastan
Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector.
Human gene therapy 1998;9(3):287-93.
1998: Partha S Chowdhury; Jaye L Viner; Richard Beers; Ira Pastan
Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):669-74.
1998: Hirohide Sawada; Kazuhiro Nishii; T Suzuki; K Hasegawa; T Hata; I Nagatsu; R J Kreitman; Ira Pastan; Toshiharu Nagatsu; Kazuto Kobayashi
Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system.
Journal of neuroscience research 1998;51(2):162-73.
1998: D Shen; Ira Pastan; Michael M Gottesman
Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.
Cancer research 1998;58(2):268-75.
1998: George Vasmatzis; M Essand; Ulrich Brinkmann; Byungkook Lee; Ira Pastan
Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):300-4.
1998: C G Lee; Ira Pastan; Michael M Gottesman
Retroviral transfer of human MDR1 gene into human T lymphocytes.
Methods in enzymology 1998;292():557-72.
1998: Thomas Licht; Michael M Gottesman; Ira Pastan
Retroviral transfer of multidrug transporter to murine hematopoietic stem cells.
Methods in enzymology 1998;292():546-57.
1998: Y Sugimoto; Michael M Gottesman; Ira Pastan; Takashi Tsuruo
Construction of MDR1 vectors for gene therapy.
Methods in enzymology 1998;292():523-37.
1998: S Zhang; Y Sugimoto; T Shoshani; Ira Pastan; Michael M Gottesman
pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein.
Methods in enzymology 1998;292():474-80.
1998: CA Hrycyna; M Ramachandra; Ira Pastan; Michael M Gottesman
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Methods in enzymology 1998;292():456-73.
1998: M Ramachandra; Michael M Gottesman; Ira Pastan
Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells.
Methods in enzymology 1998;292():441-55.
1998: S Dey; M Ramachandra; Ira Pastan; Michael M Gottesman; Suresh V Ambudkar
Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.
Methods in enzymology 1998;292():318-28.
1998: Michael M Gottesman; Carol Cardarelli; S Goldenberg; Thomas Licht; Ira Pastan
Selection and maintenance of multidrug-resistant cells.
Methods in enzymology 1998;292():248-58.
1998: LH Pai; Ira Pastan
Clinical trials with Pseudomonas exotoxin immunotoxins.
Current topics in microbiology and immunology 1998;234():83-96.
1998: David FitzGerald; Ira Pastan; J Robertus
Clinical applications of immunotoxins. Introduction.
Current topics in microbiology and immunology 1998;234():1-11.
1997: V Rajagopal; Ira Pastan; Robert J Kreitman
A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs.
Protein engineering 1997;10(12):1453-9.
1997: Ira Pastan
Targeted therapy of cancer with recombinant immunotoxins.
Biochimica et biophysica acta 1997;1333(2):C1-6.
1997: Chuanchu Wu; Hisataka Kobayashi; B Sun; Tae M Yoo; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Ira Pastan; Martin W Brechbiel
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorganic & medicinal chemistry 1997;5(10):1925-34.
1997: C G Lee; Kuan-Teh Jeang; Malcolm Martin; Ira Pastan; Michael M Gottesman
Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene.
Antisense & nucleic acid drug development 1997;7(5):511-22.
1997: S Dey; M Ramachandra; Ira Pastan; Michael M Gottesman; Suresh V Ambudkar
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10594-9.
1997: Henk Rozemuller; Elwin J C Rombouts; Ivo P Touw; DJ FitzGerald; Robert J Kreitman; Ira Pastan; Anton Hagenbeek; Anton Martens
Sensitivity of human acute myeloid leukaemia to diphtheria toxin-GM-CSF fusion protein.
British journal of haematology 1997;98(4):952-9.
1997: E Mansfield; P Amlot; Ira Pastan; David J FitzGerald
Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors.
Blood 1997;90(5):2020-6.
1997: Atul Maini; Gilda G Hillman; Gabriel P Haas; Ching Y Wang; EJ Montecillo; Fasahat H Hamzavi; J Edson Pontes; Pamela Leland; Ira Pastan; Waldemar Debinski; Raj K Puri
Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin.
The Journal of urology 1997;158(3 Pt 1):948-53.
1997: Vasily Ogryzko; E Brinkmann; Bruce H Howard; Ira Pastan; Ulrich Brinkmann
Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells.
Biochemistry 1997;36(31):9493-500.
1997: H Funatomi; Jun Itakura; Toshiyuki Ishiwata; Ira Pastan; S A Thompson; G R Johnson; Murray Korc
Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.
International journal of cancer. Journal international du cancer 1997;72(3):512-7.
1997: Robert J Kreitman; Ira Pastan
Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells.
Blood 1997;90(1):252-9.
1997: D M Roscoe; LH Pai; Ira Pastan
Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins.
European journal of immunology 1997;27(6):1459-68.
1997: Lixin Lang; Elaine M Jagoda; Chuanchu Wu; Martin W Brechbiel; Otto A Gansow; Ira Pastan; Chang H Paik; Jorge Carrasquillo; William Eckelman
Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):53-61.
1997: Ulrich Brinkmann; KO Webber; A Di Carlo; Richard Beers; Partha S Chowdhury; K Chang; V Chaudhary; M Gallo; Ira Pastan
Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers.
International journal of cancer. Journal international du cancer 1997;71(4):638-44.
1997: Hisataka Kobayashi; Tae M Yoo; D Drumm; Meyoung-Kon Kim; BF Sun; Nhat Le; KO Webber; Ira Pastan; Thomas Waldmann; Chang H Paik; Jorge Carrasquillo
Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
Cancer research 1997;57(10):1955-61.
1997: Syed R Husain; P Gill; Robert J Kreitman; Ira Pastan; Raj K Puri
Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
Molecular medicine (Cambridge, Mass.) 1997;3(5):327-38.
1997: E Mansfield; M F Chiron; P Amlot; Ira Pastan; David J FitzGerald
Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells.
Biochemical Society transactions 1997;25(2):709-14.
1997: Chuanchu Wu; E Jagoda; Martin W Brechbiel; KO Webber; Ira Pastan; Otto A Gansow; William Eckelman
Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.
Bioconjugate chemistry 1997;8(3):365-9.
1997: Yoram Reiter; A Di Carlo; L Fugger; J Engberg; Ira Pastan
Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4631-6.
1997: Ulrich Brinkmann; A Di Carlo; George Vasmatzis; N Kurochkina; Richard Beers; Byungkook Lee; Ira Pastan
Stabilization of a recombinant Fv fragment by base-loop interconnection and V(H)-V(L) permutation.
Journal of molecular biology 1997;268(1):107-17.
1997: Toshio Ohshima; Gary J Murray; William D Swaim; Glenn Longenecker; Jane M Quirk; C O Cardarelli; Y Sugimoto; Ira Pastan; Michael M Gottesman; Roscoe O Brady; Ashok Kulkarni
alpha-Galactosidase A deficient mice: a model of Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2540-4.
1997: Syed R Husain; NI Obiri; P Gill; T Zheng; Ira Pastan; Waldemar Debinski; Raj K Puri
Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(2):151-6.
1997: Tae M Yoo; H K Chang; C W Choi; KO Webber; Nhat Le; IS Kim; William Eckelman; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Technetium-99m labeling and biodistribution of anti-TAC disulfide-stabilized Fv fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(2):294-300.
1997: Ulrich Brinkmann; E Mansfield; Ira Pastan
Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins.
Apoptosis : an international journal on programmed cell death 1997;2(2):192-8.
1997: Partha S Chowdhury; K Chang; Ira Pastan
Isolation of anti-mesothelin antibodies from a phage display library.
Molecular immunology 1997;34(1):9-20.
1997: Thomas Licht; F Herrmann; Michael M Gottesman; Ira Pastan
In vivo drug-selectable genes: a new concept in gene therapy.
Stem cells (Dayton, Ohio) 1997;15(2):104-11.
1997: Y Sugimoto; S Sato; S Tsukahara; M Suzuki; E Okochi; Michael M Gottesman; Ira Pastan; Takashi Tsuruo
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Cancer gene therapy 1997;4(1):51-8.
1997: Axel Wellmann; Laszlo Krenacs; T Fest; U Scherf; Ira Pastan; Mark Raffeld; Ulrich Brinkmann
Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms.
The American journal of pathology 1997;150(1):25-30.
1996: Raj K Puri; D S Hoon; Pamela Leland; P Snoy; R W Rand; Ira Pastan; Robert J Kreitman
Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.
Cancer research 1996;56(24):5631-7.
1996: I A Lorimer; A Keppler-Hafkemeyer; Richard Beers; Charles N Pegram; Darell D Bigner; Ira Pastan
Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14815-20.
1996: J M Aran; Thomas Licht; Michael M Gottesman; Ira Pastan
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
Human gene therapy 1996;7(17):2165-75.
1996: Henk Rozemuller; W J Rombouts; Ivo P Touw; DJ FitzGerald; Robert J Kreitman; Ira Pastan; Anton Hagenbeek; Anton Martens
Treatment of acute myelocytic leukemia with interleukin-6 Pseudomonas exotoxin fusion protein in a rat leukemia model.
Leukemia 1996;10(11):1796-803.
1996: Yoram Reiter; Ulrich Brinkmann; Byungkook Lee; Ira Pastan
Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.
Nature biotechnology 1996;14(10):1239-45.
1996: Michael M Gottesman; Ira Pastan; Suresh V Ambudkar
P-glycoprotein and multidrug resistance.
Current opinion in genetics & development 1996;6(5):610-7.
1996: M Ramachandra; Suresh V Ambudkar; Michael M Gottesman; Ira Pastan; CA Hrycyna
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Molecular biology of the cell 1996;7(10):1485-98.
1996: Kazuto Kobayashi; Tamae Ohye; Ira Pastan; Toshiharu Nagatsu
A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting.
Nucleic acids research 1996;24(18):3653-5.
1996: U Scherf; I Benhar; KO Webber; Ira Pastan; Ulrich Brinkmann
Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1523-31.
1996: E Mansfield; Ira Pastan; David J FitzGerald
Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies.
Bioconjugate chemistry 1996;7(5):557-63.
1996: Hisataka Kobayashi; Tae M Yoo; IS Kim; Meyoung-Kon Kim; Nhat Le; KO Webber; Ira Pastan; Chang H Paik; William Eckelman; Jorge Carrasquillo
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer research 1996;56(16):3788-95.
1996: M Baudard; Terence R Flotte; J M Aran; Alain THIERRY; Ira Pastan; M G Pang; William G Kearns; Michael M Gottesman
Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes.
Human gene therapy 1996;7(11):1309-22.
1996: S W Johnson; D Shen; Ira Pastan; Michael M Gottesman; Thomas C Hamilton
Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines.
Experimental cell research 1996;226(1):133-9.
1996: Raj K Puri; Pamela Leland; NI Obiri; Syed R Husain; J Mule; Ira Pastan; Robert J Kreitman
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity.
Cellular immunology 1996;171(1):80-6.
1996: M Li; Fred Dyda; I Benhar; Ira Pastan; David Davies
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):6902-6.
1996: Yoram Reiter; A F Wright; D W Tonge; Ira Pastan
Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
International journal of cancer. Journal international du cancer 1996;67(1):113-23.
1996: R L Baldwin; M S Kobrin; T Tran; Ira Pastan; Murray Korc
Cytotoxic effects of TGF-alpha-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells.
Pancreas 1996;13(1):16-21.
1996: I Aksentijevich; Ira Pastan; Y Lunardi-Iskandar; Robert C Gallo; Michael M Gottesman; Alain THIERRY
In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells.
Human gene therapy 1996;7(9):1111-22.
1996: I Aksentijevich; Carol Cardarelli; Ira Pastan; Michael M Gottesman
Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):973-80.
1996: M Baudard; Ira Pastan; Michael M Gottesman
Transfer of the MDR1 gene into haematopoietic cells.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):1019-23.
1996: Ulrich Brinkmann; E Brinkmann; M Gallo; U Scherf; Ira Pastan
Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis.
Biochemistry 1996;35(21):6891-9.
1996: Raj K Puri; Pamela Leland; NI Obiri; Syed R Husain; Robert J Kreitman; Gabriel P Haas; Ira Pastan; Waldemar Debinski
Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR).
Blood 1996;87(10):4333-9.
1996: DA Mavroudis; YZ Jiang; Nancy Hensel; P Lewalle; Daniel Couriel; Robert J Kreitman; Ira Pastan; A John Barrett
Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.
Bone marrow transplantation 1996;17(5):793-9.
1996: U Scherf; Ira Pastan; M C Willingham; Ulrich Brinkmann
The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2670-4.
1996: CR King; P H Fischer; R F Rando; Ira Pastan
The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein.
Seminars in cancer biology 1996;7(2):79-86.
1996: T Licht; Ira Pastan; Michael M Gottesman; F Herrmann
The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders.
Annals of hematology 1996;72(4):184-93.
1996: C T Kuan; Ira Pastan
Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
Biochemistry 1996;35(9):2872-7.
1996: J M Aran; ursula germann; Michael M Gottesman; Ira Pastan
Construction and characterization of a selectable multidrug resistance-glucocerebrosidase fusion gene.
Cytokines and molecular therapy 1996;2(1):47-57.
1996: Ulrich Brinkmann; M Gallo; Mihael H Polymeropoulos; Ira Pastan
The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines.
Genome research 1996;6(3):187-94.
1996: L H Pai; Robert Wittes; A Setser; M C Willingham; Ira Pastan
Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin.
Nature medicine 1996;2(3):350-3.
1996: C T Kuan; Ira Pastan
Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):974-8.
1996: Yoram Reiter; Ira Pastan
Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):245-52.
1996: ursula germann; Timothy C Chambers; Suresh V Ambudkar; Thomas Licht; Carol Cardarelli; Ira Pastan; Michael M Gottesman
Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells.
The Journal of biological chemistry 1996;271(3):1708-16.
1996: K Chang; Ira Pastan
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):136-40.
1996: Ira Pastan; L H Pai; Ulrich Brinkmann; D FitzGerald
Recombinant immunotoxins.
Breast cancer research and treatment 1996;38(1):3-9.
1996: T I Prior; S Kunwar; Ira Pastan
Studies on the activity of barnase toxins in vitro and in vivo.
Bioconjugate chemistry 1996;7(1):23-9.
1995: C T Kuan; L H Pai; Ira Pastan
Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1589-94.
1995: Darell D Bigner; Gary E Archer; Roger E McLendon; Henry S Friedman; Herbert E Fuchs; L H Pai; J E Herndon; Ira Pastan
Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1545-55.
1995: Yoram Reiter; Ulrich Brinkmann; S H Jung; Ira Pastan; Byungkook Lee
Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation.
Protein engineering 1995;8(12):1323-31.
1995: C W Choi; Lixin Lang; J T Lee; KO Webber; Tae M Yoo; H K Chang; Nhat Le; Elaine M Jagoda; Chang H Paik; Ira Pastan
Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.
Cancer research 1995;55(22):5323-9.
1995: Waldemar Debinski; NI Obiri; S K Powers; Ira Pastan; Raj K Puri
Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1253-8.
1995: J A Campain; M L Slovak; Patricia V Schoenlein; N C Popescu; Michael M Gottesman; Ira Pastan
Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines.
Somatic cell and molecular genetics 1995;21(6):451-71.
1995: Dietmar P Berger; L Herbstritt; U Hellerich; S Schulzke; WA Dengler; M Gallo; Ira Pastan; Roland Mertelsmann; Heinz-Herbert Fiebig
Cytotoxicity of TGF alpha-PE40 and correlation to expression of epidermal growth factor receptor.
European journal of cancer (Oxford, England : 1990) 1995;31A(12):2067-72.
1995: Timothy C Chambers; ursula germann; Michael M Gottesman; Ira Pastan; J F Kuo; Suresh V Ambudkar
Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.
Biochemistry 1995;34(43):14156-62.
1995: Ulrich Brinkmann; E Brinkmann; M Gallo; Ira Pastan
Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10427-31.
1995: I Benhar; Ira Pastan
Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
The Journal of biological chemistry 1995;270(40):23373-80.
1995: Robert J Kreitman; Ira Pastan
Targeting Pseudomonas exotoxin to hematologic malignancies.
Seminars in cancer biology 1995;6(5):297-306.
1995: M Li; Fred Dyda; I Benhar; Ira Pastan; David Davies
The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9308-12.
1995: I Benhar; Ira Pastan
Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(9):1023-9.
1995: W Debinski; Ira Pastan
Recombinant F(ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(9):1015-22.
1995: I A Lorimer; Ira Pastan
Random recombination of antibody single chain Fv sequences after fragmentation with DNaseI in the presence of Mn2+.
Nucleic acids research 1995;23(15):3067-8.
1995: I A Lorimer; C J Wikstrand; Surinder Batra; Darell D Bigner; Ira Pastan
Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):859-64.
1995: Robert J Kreitman; Raj K Puri; Ira Pastan
Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.
Cancer research 1995;55(15):3357-63.
1995: I Benhar; Yoram Reiter; L H Pai; Ira Pastan
Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice.
International journal of cancer. Journal international du cancer 1995;62(3):351-5.
1995: Waldemar Debinski; NI Obiri; Ira Pastan; Raj K Puri
A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4.
The Journal of biological chemistry 1995;270(28):16775-80.
1995: Thomas Licht; I Aksentijevich; Michael M Gottesman; Ira Pastan
Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells.
Blood 1995;86(1):111-21.
1995: Y Sugimoto; I Aksentijevich; G J Murray; R O Brady; Ira Pastan; Michael M Gottesman
Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease.
Human gene therapy 1995;6(7):905-15.
1995: Ira Pastan; L H Pai; Ulrich Brinkmann; David J FitzGerald
Recombinant toxins: new therapeutic agents for cancer.
Annals of the New York Academy of Sciences 1995;758():345-54.
1995: L Beguinot; H Yamazaki; Ira Pastan; A C Johnson
Biochemical characterization of human GCF transcription factor in tumor cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(6):699-706.
1995: Ulrich Brinkmann; Partha S Chowdhury; D M Roscoe; Ira Pastan
Phage display of disulfide-stabilized Fv fragments.
Journal of immunological methods 1995;182(1):41-50.
1995: Robert J Kreitman; R K Puri; P McPhie; Ira Pastan
Circularly permuted interleukin 4 retains proliferative and binding activity.
Cytokine 1995;7(4):311-8.
1995: Robert J Kreitman; Ira Pastan
Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor.
The Biochemical journal 1995;307 ( Pt 1)():29-37.
1995: D W Shen; S Akiyama; Patricia V Schoenlein; Ira Pastan; Michael M Gottesman
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.
British journal of cancer 1995;71(4):676-83.
1995: Ira Pastan; Gary E Archer; Roger E McLendon; H S Friedman; Herbert E Fuchs; Qing-Cheng Wang; L H Pai; J Herndon; Darell D Bigner
Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2765-9.
1995: Thomas Licht; Michael M Gottesman; Ira Pastan
Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo.
Cytokines and molecular therapy 1995;1(1):11-20.
1995: Carol Cardarelli; I Aksentijevich; Ira Pastan; Michael M Gottesman
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Cancer research 1995;55(5):1086-91.
1995: KO Webber; Yoram Reiter; Ulrich Brinkmann; Robert J Kreitman; Ira Pastan
Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog.
Molecular immunology 1995;32(4):249-58.
1995: Yoram Reiter; I Kurucz; Ulrich Brinkmann; S H Jung; Byungkook Lee; David M Segal; Ira Pastan
Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure.
Immunity 1995;2(3):281-7.
1995: Kazuto Kobayashi; S Morita; Hirohide Sawada; T Mizuguchi; K Yamada; I Nagatsu; K Fujita; R J Kreitman; Ira Pastan; Toshiharu Nagatsu
Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):1132-6.
1995: ursula germann; Timothy C Chambers; Suresh V Ambudkar; Ira Pastan; Michael M Gottesman
Effects of phosphorylation of P-glycoprotein on multidrug resistance.
Journal of bioenergetics and biomembranes 1995;27(1):53-61.
1995: G L Evans; B Ni; CA Hrycyna; D Chen; Suresh V Ambudkar; Ira Pastan; ursula germann; Michael M Gottesman
Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.
Journal of bioenergetics and biomembranes 1995;27(1):43-52.
1995: KO Webber; Robert J Kreitman; Ira Pastan
Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors.
Cancer research 1995;55(2):318-23.
1995: Michael M Gottesman; CA Hrycyna; Patricia V Schoenlein; ursula germann; Ira Pastan
Genetic analysis of the multidrug transporter.
Annual review of genetics 1995;29():607-49.
1995: Ulrich Brinkmann; E Brinkmann; Ira Pastan
Expression cloning of cDNAs that render cancer cells resistant to Pseudomonas and diphtheria toxin and immunotoxins.
Molecular medicine (Cambridge, Mass.) 1995;1(2):206-16.
1995: A Kihara; Ira Pastan
Cytotoxic activity of chimeric toxins containing the epidermal growth factor-like domain of heregulins fused to PE38KDEL, a truncated recombinant form of Pseudomonas exotoxin.
Cancer research 1995;55(1):71-7.
1994: I Benhar; E A Padlan; S H Jung; Byungkook Lee; Ira Pastan
Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12051-5.
1994: I Benhar; Ira Pastan
Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.
Protein engineering 1994;7(12):1509-15.
1994: D M Roscoe; S H Jung; I Benhar; L Pai; B K Lee; Ira Pastan
Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin.
Infection and immunity 1994;62(11):5055-65.
1994: A Kihara; Ira Pastan
Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha.
Bioconjugate chemistry 1994;5(6):532-8.
1994: Thomas Licht; Ira Pastan; Michael M Gottesman; F Herrmann
P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells.
Annals of hematology 1994;69(4):159-71.
1994: A Kihara; Ira Pastan
Small chimeric toxins containing only transforming growth factor alpha and domain III of Pseudomonas exotoxin with good antitumor activity in mice.
Cancer research 1994;54(19):5154-9.
1994: Robert J Kreitman; Raj K Puri; Pamela Leland; Byungkook Lee; Ira Pastan
Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity.
Biochemistry 1994;33(38):11637-44.
1994: J A Campain; Michael M Gottesman; Ira Pastan
A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.
Biochemistry 1994;33(37):11327-32.
1994: W Debinski; R K Puri; Ira Pastan
Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 1994;58(5):744-8.
1994: Enrique Mesri; M Ono; Robert J Kreitman; M Klagsbrun; Ira Pastan
The heparin-binding domain of heparin-binding EGF-like growth factor can target Pseudomonas exotoxin to kill cells exclusively through heparan sulfate proteoglycans.
Journal of cell science 1994;107 ( Pt 9)():2599-608.
1994: Raj K Puri; Pamela Leland; Robert J Kreitman; Ira Pastan
Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein.
International journal of cancer. Journal international du cancer 1994;58(4):574-81.
1994: I H Lelong; Carol Cardarelli; Michael M Gottesman; Ira Pastan
GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells.
Biochemistry 1994;33(30):8921-9.
1994: D I Morris; L M Greenberger; E P Bruggemann; C Cardarelli; Michael M Gottesman; Ira Pastan; K B Seamon
Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.
Molecular pharmacology 1994;46(2):329-37.
1994: ursula germann; Patricia V Schoenlein; Drazen Zimonjic; N C Popescu; Ira Pastan; Michael M Gottesman
Putative "MDR enhancer" is located on human chromosome 20 and not linked to the MDR1 gene on chromosome 7.
Genes, chromosomes & cancer 1994;10(4):267-74.
1994: Robert J Kreitman; Raj K Puri; Ira Pastan
A circularly permuted recombinant interleukin 4 toxin with increased activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6889-93.
1994: Yoram Reiter; Ulrich Brinkmann; S H Jung; Byungkook Lee; P G Kasprzyk; CR King; Ira Pastan
Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
The Journal of biological chemistry 1994;269(28):18327-31.
1994: Yoram Reiter; Robert J Kreitman; Ulrich Brinkmann; Ira Pastan
Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
International journal of cancer. Journal international du cancer 1994;58(1):142-9.
1994: M Choe; KO Webber; Ira Pastan
B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.
Cancer research 1994;54(13):3460-7.
1994: L Camera; S Kinuya; Kayhan Garmestani; Martin W Brechbiel; Chuanchu Wu; L H Pai; T J McMurry; Otto A Gansow; Ira Pastan; Chang H Paik
Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA).
European journal of nuclear medicine 1994;21(7):640-6.
1994: I Benhar; Ulrich Brinkmann; KO Webber; Ira Pastan
Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.
Bioconjugate chemistry 1994;5(4):321-6.
1994: Y Sugimoto; I Aksentijevich; Michael M Gottesman; Ira Pastan
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
Bio/technology (Nature Publishing Company) 1994;12(7):694-8.
1994: Robert J Kreitman; C N Chang; D V Hudson; C Queen; P Bailon; Ira Pastan
Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model.
International journal of cancer. Journal international du cancer 1994;57(6):856-64.
1994: Michael M Gottesman; ursula germann; I Aksentijevich; Y Sugimoto; Carol Cardarelli; Ira Pastan
Gene transfer of drug resistance genes. Implications for cancer therapy.
Annals of the New York Academy of Sciences 1994;716():126-38; discussion 138-43.
1994: Ulrich Brinkmann; Ira Pastan
Immunotoxins against cancer.
Biochimica et biophysica acta 1994;1198(1):27-45.
1994: C Theuer; S Kasturi; Ira Pastan
Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes.
Biochemistry 1994;33(19):5894-900.
1994: Yoram Reiter; L H Pai; Ulrich Brinkmann; Qing-Cheng Wang; Ira Pastan
Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Cancer research 1994;54(10):2714-8.
1994: Yoram Reiter; Ulrich Brinkmann; Robert J Kreitman; S H Jung; Byungkook Lee; Ira Pastan
Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
Biochemistry 1994;33(18):5451-9.
1994: I Benhar; Qing-Cheng Wang; D FitzGerald; Ira Pastan
Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
The Journal of biological chemistry 1994;269(18):13398-404.
1994: L Camera; S Kinuya; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel; L H Pai; T J McMurry; Otto A Gansow; Ira Pastan; Chang H Paik
Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(5):882-9.
1994: Yoram Reiter; Ulrich Brinkmann; KO Webber; S H Jung; Byungkook Lee; Ira Pastan
Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
Protein engineering 1994;7(5):697-704.
1994: S H Jung; Ira Pastan; Byungkook Lee
Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3.
Proteins 1994;19(1):35-47.
1994: Michael Siegsmund; H Yamazaki; Ira Pastan
Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.
The Journal of urology 1994;151(5):1396-9.
1994: J M Aran; Michael M Gottesman; Ira Pastan
Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3176-80.
1994: K Chang; Ira Pastan
Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line.
International journal of cancer. Journal international du cancer 1994;57(1):90-7.
1994: Raj K Puri; P T Mehrotra; Pamela Leland; Robert J Kreitman; J P Siegel; Ira Pastan
A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3693-700.
1994: Raj K Puri; Waldemar Debinski; NI Obiri; Robert J Kreitman; Ira Pastan
Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin.
Cellular immunology 1994;154(1):369-79.
1994: Wilfred D Stein; Carol Cardarelli; Ira Pastan; Michael M Gottesman
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.
Molecular pharmacology 1994;45(4):763-72.
1994: C T Kuan; Qing-Cheng Wang; Ira Pastan
Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.
The Journal of biological chemistry 1994;269(10):7610-6.
1994: Robert J Kreitman; Ira Pastan
Recombinant single-chain immunotoxins against T and B cell leukemias.
Leukemia & lymphoma 1994;13(1-2):1-10.
1994: T Saito; R J Kreitman; Shuichi Hanada; T Makino; Atae Utsunomiya; Tomoyuki Sumizawa; Terukatsu Arima; C N Chang; D Hudson; Ira Pastan
Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor.
Cancer research 1994;54(4):1059-64.
1994: Peter C Phillips; C Levow; M Catterall; O M Colvin; Ira Pastan; Henry Brem
Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.
Cancer research 1994;54(4):1008-15.
1994: Michael Siegsmund; Carol Cardarelli; I Aksentijevich; Y Sugimoto; Ira Pastan; Michael M Gottesman
Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells.
The Journal of urology 1994;151(2):485-91.
1994: Robert J Kreitman; P Bailon; V K Chaudhary; David J FitzGerald; Ira Pastan
Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma.
Blood 1994;83(2):426-34.
1994: M Draoui; C B Siegall; D FitzGerald; Ira Pastan; Terry W Moody
TGF alpha-PE40 inhibits non-small cell lung cancer growth.
Life sciences 1994;54(7):445-53.
1994: L H Pai; Ira Pastan
Immunotoxins and recombinant toxins for cancer treatment.
Important advances in oncology 1994;():3-19.
1994: W Debinski; Ira Pastan
An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin.
Bioconjugate chemistry 1994;5(1):40-6.
1994: Robert J Kreitman; Ira Pastan
Recombinant toxins.
Advances in pharmacology (San Diego, Calif.) 1994;28():193-219.
1994: S Kameyama; H Kawamata; Ira Pastan; Ryoichi Oyasu
Cytotoxic effect of a fusion protein from transforming growth factor alpha and Pseudomonas exotoxin on rat and human bladder carcinoma cells in vitro.
Journal of cancer research and clinical oncology 1994;120(9):507-12.
1994: K T Nguyen; B Liu; K Ueda; Michael M Gottesman; Ira Pastan; K V Chin
Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.
Oncology research 1994;6(2):71-7.
1994: P H Fischer; R E Bird; P G Kasprzyk; CR King; N A Turner; Ira Pastan; A Kihara; J Batra
In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein.
Advances in enzyme regulation 1994;34():119-28.
1994: Michael M Gottesman; G H Mickisch; Ira Pastan
In vivo models of P-glycoprotein-mediated multidrug resistance.
Cancer treatment and research 1994;73():107-28.
1994: Michael M Gottesman; Suresh V Ambudkar; B Ni; J M Aran; Y Sugimoto; Carol Cardarelli; Ira Pastan
Exploiting multidrug resistance to treat cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():677-83.
1994: Clay B Siegall; SL Gawlak; Dana F Chace; J R Merwin; Ira Pastan
In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins.
Bioconjugate chemistry 1994;5(1):77-83.
1993: S Altuvia; Wilfred D Stein; S Goldenberg; S E Kane; Ira Pastan; Michael M Gottesman
Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.
The Journal of biological chemistry 1993;268(36):27127-32.
1993: C P Leamon; Ira Pastan; Philip S Low
Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain.
The Journal of biological chemistry 1993;268(33):24847-54.
1993: Robert J Kreitman; Ira Pastan
Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.
Bioconjugate chemistry 1993;4(6):581-5.
1993: L Camera; S Kinuya; Kayhan Garmestani; L H Pai; Martin W Brechbiel; Otto A Gansow; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts.
Nuclear medicine and biology 1993;20(8):955-62.
1993: SL Gawlak; Ira Pastan; Clay B Siegall
Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin.
Bioconjugate chemistry 1993;4(6):483-9.
1993: Alexey G Zdanovsky; M Chiron; Ira Pastan; David J FitzGerald
Mechanism of action of Pseudomonas exotoxin. Identification of a rate-limiting step.
The Journal of biological chemistry 1993;268(29):21791-9.
1993: L Homolya; Z Holló; ursula germann; Ira Pastan; Michael M Gottesman; Balázs Sarkadi
Fluorescent cellular indicators are extruded by the multidrug resistance protein.
The Journal of biological chemistry 1993;268(29):21493-6.
1993: Qing-Cheng Wang; L H Pai; W Debinski; David J FitzGerald; Ira Pastan
Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.
Cancer research 1993;53(19):4588-94.
1993: Ira Pastan
c-erbB-2 and human cancer.
Japanese journal of cancer research : Gann 1993;84(10):inside front cover.
1993: S Kunwar; L H Pai; Ira Pastan
Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells.
Journal of neurosurgery 1993;79(4):569-76.
1993: C P Theuer; Ira Pastan
Immunotoxins and recombinant toxins in the treatment of solid carcinomas.
American journal of surgery 1993;166(3):284-8.
1993: Ya-Min Fu; Enrique Mesri; Zu-Xi Yu; Robert J Kreitman; Ira Pastan; Stephen E Epstein
Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin.
Cardiovascular research 1993;27(9):1691-7.
1993: Y H Xu; S F Peng; W L Jiang; Y Zhu; V Chandhary; D FitzGerald; Ira Pastan
[Gene cloning, expression of fusion protein TGF alpha-PE 40 and its inhibition activity on cancer cell growth].
Shi yan sheng wu xue bao 1993;26(3):289-95.
1993: C P Theuer; J Buchner; D FitzGerald; Ira Pastan
The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7774-8.
1993: Ulrich Brinkmann; Yoram Reiter; S H Jung; Byungkook Lee; Ira Pastan
A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7538-42.
1993: Ira Pastan; E Lovelace; A V Rutherford; S Kunwar; M C Willingham; D M Peehl
PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells.
Journal of the National Cancer Institute 1993;85(14):1149-54.
1993: W Debinski; Raj K Puri; Robert J Kreitman; Ira Pastan
A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin.
The Journal of biological chemistry 1993;268(19):14065-70.
1993: D Fitzgerald; Ira Pastan
Pseudomonas exotoxin and recombinant immunotoxins derived from it.
Annals of the New York Academy of Sciences 1993;685():740-5.
1993: L Camera; S Kinuya; L H Pai; Kayhan Garmestani; Martin W Brechbiel; Otto A Gansow; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts.
Cancer research 1993;53(12):2834-9.
1993: R Hoess; U Brinkmann; T Handel; Ira Pastan
Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3.
Gene 1993;128(1):43-9.
1993: C Jhappan; C Stahle; M Wolff; Glenn Merlino; Ira Pastan
An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice.
Cellular immunology 1993;149(1):99-106.
1993: C P Theuer; David J FitzGerald; Ira Pastan
A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer.
The Journal of urology 1993;149(6):1626-32.
1993: J A Campain; R Padmanabhan; J Hwang; Michael M Gottesman; Ira Pastan
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.
Journal of cellular physiology 1993;155(2):414-25.
1993: Yasuhiko Kitadai; H Yamazaki; Wataru Yasui; E Kyo; Hiroshi Yokozaki; Goro Kajiyama; A C Johnson; Ira Pastan; Eiichi Tahara
GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(4):291-6.
1993: Robert J Kreitman; V K Chaudhary; Thomas Waldmann; Barrie Hanchard; Beverley Cranston; David J FitzGerald; Ira Pastan
Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia.
Leukemia 1993;7(4):553-62.
1993: Ulrich Brinkmann; B K Lee; Ira Pastan
Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2774-82.
1993: Enrique Mesri; Robert J Kreitman; Ya-Min Fu; Stephen E Epstein; Ira Pastan
Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells.
The Journal of biological chemistry 1993;268(7):4853-62.
1993: Janendra Batra; S Kasturi; M G Gallo; Richard Voorman; S M Maio; V K Chaudhary; Ira Pastan
Insertion of constant region domains of human IgG1 into CD4-PE40 increases its plasma half-life.
Molecular immunology 1993;30(4):379-86.
1993: Ali I Fattom; Rachel Schneerson; D C Watson; W W Karakawa; D Fitzgerald; Ira Pastan; X Li; Joseph Shiloach; Dolores A Bryla; John B Robbins
Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A.
Infection and immunity 1993;61(3):1023-32.
1993: Robert J Kreitman; Janendra Batra; S Seetharam; V K Chaudhary; David J FitzGerald; Ira Pastan
Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.
Bioconjugate chemistry 1993;4(2):112-20.
1993: Robert J Kreitman; H J Hansen; A L Jones; David J FitzGerald; D M Goldenberg; Ira Pastan
Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice.
Cancer research 1993;53(4):819-25.
1993: ursula germann; Ira Pastan; Michael M Gottesman
P-glycoproteins: mediators of multidrug resistance.
Seminars in cell biology 1993;4(1):63-76.
1993: Ulrich Brinkmann; M Gallo; E Brinkmann; S Kunwar; Ira Pastan
A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):547-51.
1993: C P Theuer; Robert J Kreitman; David J FitzGerald; Ira Pastan
Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity.
Cancer research 1993;53(2):340-7.
1993: L H Pai; Ira Pastan
Immunotoxin therapy for cancer.
JAMA : the journal of the American Medical Association 1993;269(1):78-81.
1993: C Spence; M Nachman; M K Gately; Robert J Kreitman; Ira Pastan; P Bailon
Affinity purification and characterization of anti-Tac(Fv)-C3-PE38KDEL: A highly potent cytotoxic agent specific to cells bearing IL-2 receptors.
Bioconjugate chemistry 1993;4(1):63-8.
1993: K V Chin; Ira Pastan; Michael M Gottesman
Function and regulation of the human multidrug resistance gene.
Advances in cancer research 1993;60():157-80.
1993: G H Mickisch; L H Pai; Michael Siegsmund; J Campain; Michael M Gottesman; Ira Pastan
Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice.
The Journal of urology 1993;149(1):174-8.
1993: Ira Pastan
Recombinant immunotoxins: new therapeutic agents for cancer treatment.
Cancer detection and prevention 1993;17(2):289-93.
1993: L H Pai; Ira Pastan
The use of immunotoxins for cancer therapy.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1606-9.
1993: Michael M Gottesman; Ira Pastan
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Annual review of biochemistry 1993;62():385-427.
1992: M Ogata; C M Fryling; Ira Pastan; David J FitzGerald
Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.
The Journal of biological chemistry 1992;267(35):25396-401.
1992: S J Currier; S E Kane; M C Willingham; Carol Cardarelli; Ira Pastan; Michael M Gottesman
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
The Journal of biological chemistry 1992;267(35):25153-9.
1992: E DelaFlor-Weiss; Christine Richardson; Maureen Ward; A Himelstein; L Smith; S Podda; Michael M Gottesman; Ira Pastan; Arthur Bank
Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.
Blood 1992;80(12):3106-11.
1992: S Kasturi; A Kihara; D FitzGerald; Ira Pastan
Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm.
The Journal of biological chemistry 1992;267(32):23427-33.
1992: David J FitzGerald; Ira Pastan
Pseudomonas exotoxin: recombinant conjugates as therapeutic agents.
Biochemical Society transactions 1992;20(4):731-4.
1992: Robert J Kreitman; V K Chaudhary; R W Kozak; David J FitzGerald; T A Waldman; Ira Pastan
Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.
Blood 1992;80(9):2344-52.
1992: Robert J Kreitman; W P Schneider; C Queen; M Tsudo; David J FitzGerald; Thomas Waldmann; Ira Pastan
Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2810-5.
1992: S Podda; Maureen Ward; A Himelstein; Christine Richardson; E de la Flor-Weiss; L Smith; Michael M Gottesman; Ira Pastan; Arthur Bank
Transfer and expression of the human multiple drug resistance gene into live mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9676-80.
1992: E P Bruggemann; S J Currier; Michael M Gottesman; Ira Pastan
Characterization of the azidopine and vinblastine binding site of P-glycoprotein.
The Journal of biological chemistry 1992;267(29):21020-6.
1992: W Debinski; Ira Pastan
Monovalent immunotoxin containing truncated form of Pseudomonas exotoxin as potent antitumor agent.
Cancer research 1992;52(19):5379-85.
1992: J R Merwin; M J Lynch; J A Madri; Ira Pastan; Clay B Siegall
Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.
Cancer research 1992;52(18):4995-5001.
1992: Suresh V Ambudkar; I H Lelong; Jin Zhang; Carol Cardarelli; Michael M Gottesman; Ira Pastan
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8472-6.
1992: Raj K Puri; D FitzGerald; Pamela Leland; R W Kozak; Ira Pastan
In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin.
Cellular immunology 1992;143(2):324-34.
1992: J Buchner; Ira Pastan; Ulrich Brinkmann
A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.
Analytical biochemistry 1992;205(2):263-70.
1992: Sadatoshi Biro; C B Siegall; Ya-Min Fu; E Speir; Ira Pastan; Stephen E Epstein
In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells.
Circulation research 1992;71(3):640-5.
1992: C P Theuer; D FitzGerald; Ira Pastan
A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing.
The Journal of biological chemistry 1992;267(24):16872-7.
1992: G H Mickisch; L H Pai; Michael M Gottesman; Ira Pastan
Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.
Cancer research 1992;52(16):4427-32.
1992: W Debinski; B Karlsson; L Lindholm; C B Siegall; M C Willingham; D FitzGerald; Ira Pastan
Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice.
The Journal of clinical investigation 1992;90(2):405-11.
1992: Brian P Sorrentino; S J Brandt; David M Bodine; Michael M Gottesman; Ira Pastan; Amanda P Cline; A W Nienhuis
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
Science (New York, N.Y.) 1992;257(5066):99-103.
1992: Janendra Batra; P G Kasprzyk; R E Bird; Ira Pastan; CR King
Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5867-71.
1992: K V Chin; S S Chauhan; I Abraham; K E Sampson; A J Krolczyk; M Wong; Bernard P Schimmer; Ira Pastan; Michael M Gottesman
Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.
Journal of cellular physiology 1992;152(1):87-94.
1992: K Chang; Ira Pastan; M C Willingham
Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas.
International journal of cancer. Journal international du cancer 1992;51(4):548-54.
1992: I H Lelong; R Padmanabhan; E Lovelace; Ira Pastan; Michael M Gottesman
ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-V1 plasma membrane vesicles.
FEBS letters 1992;304(2-3):256-60.
1992: L H Pai; Janendra Batra; David J FitzGerald; M C Willingham; Ira Pastan
Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys.
Cancer research 1992;52(11):3189-93.
1992: J Buchner; Ulrich Brinkmann; Ira Pastan
Renaturation of a single-chain immunotoxin facilitated by chaperones and protein disulfide isomerase.
Bio/technology (Nature Publishing Company) 1992;10(6):682-5.
1992: G H Mickisch; A Rahman; Ira Pastan; Michael M Gottesman
Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin.
Journal of the National Cancer Institute 1992;84(10):804-5.
1992: Patricia V Schoenlein; D W Shen; John T Barrett; Ira Pastan; Michael M Gottesman
Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.
Molecular biology of the cell 1992;3(5):507-20.
1992: T I Prior; David J FitzGerald; Ira Pastan
Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol.
Biochemistry 1992;31(14):3555-9.
1992: Robert J Kreitman; C B Siegall; David J FitzGerald; Joshua Epstein; Bart Barlogie; Ira Pastan
Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma.
Blood 1992;79(7):1775-80.
1992: Ulrich Brinkmann; J Buchner; Ira Pastan
Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3075-9.
1992: Ulrich Brinkmann; L H Pai; David J FitzGerald; Ira Pastan
Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3065-9.
1992: Robert J Kreitman; D FitzGerald; Ira Pastan
Targeting growth factor receptors with fusion toxins.
International journal of immunopharmacology 1992;14(3):465-72.
1992: K Chang; L H Pai; Harvey I Pass; H W Pogrebniak; Ming Tsao; Ira Pastan; M C Willingham
Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma.
The American journal of surgical pathology 1992;16(3):259-68.
1992: G H Mickisch; I Aksentijevich; Patricia V Schoenlein; L J Goldstein; H Galski; C Stahle; D H Sachs; Ira Pastan; Michael M Gottesman
Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.
Blood 1992;79(4):1087-93.
1992: K Chang; Ira Pastan; M C Willingham
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium.
International journal of cancer. Journal international du cancer 1992;50(3):373-81.
1992: Ali I Fattom; Joseph Shiloach; D Bryla; D Fitzgerald; Ira Pastan; W W Karakawa; John B Robbins; Rachel Schneerson
Comparative immunogenicity of conjugates composed of the Staphylococcus aureus type 8 capsular polysaccharide bound to carrier proteins by adipic acid dihydrazide or N-succinimidyl-3-(2-pyridyldithio)propionate.
Infection and immunity 1992;60(2):584-9.
1992: A C Johnson; R Kageyama; N C Popescu; Ira Pastan
Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.
The Journal of biological chemistry 1992;267(3):1689-94.
1992: K V Chin; K Ueda; Ira Pastan; Michael M Gottesman
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
Science (New York, N.Y.) 1992;255(5043):459-62.
1992: Thomas Waldmann; Ira Pastan; Otto A Gansow; Richard P. Junghans
The multichain interleukin-2 receptor: a target for immunotherapy.
Annals of internal medicine 1992;116(2):148-60.
1992: K Chang; L H Pai; Janendra Batra; Ira Pastan; M C Willingham
Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium.
Cancer research 1992;52(1):181-6.
1992: D FitzGerald; V K Chaudhary; Robert J Kreitman; C B Siegall; Ira Pastan
Generation of chimeric toxins.
Targeted diagnosis and therapy 1992;7():447-62.
1992: Robert J Kreitman; C B Siegall; V K Chaudhary; David J FitzGerald; Ira Pastan
Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin.
Bioconjugate chemistry 1992;3(1):63-8.
1992: Robert J Kreitman; V K Chaudhary; C B Siegall; David J FitzGerald; Ira Pastan
Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand.
Bioconjugate chemistry 1992;3(1):58-62.
1992: Ira Pastan; V Chaudhary; David J FitzGerald
Recombinant toxins as novel therapeutic agents.
Annual review of biochemistry 1992;61():331-54.
1992: Lori J Goldstein; Ira Pastan; Michael M Gottesman
Multidrug resistance in human cancer.
Critical reviews in oncology/hematology 1992;12(3):243-53.
1991: Ira Pastan; D FitzGerald
Recombinant toxins for cancer treatment.
Science (New York, N.Y.) 1991;254(5035):1173-7.
1991: V K Chaudhary; David J FitzGerald; Ira Pastan
A proper amino terminus of diphtheria toxin is important for cytotoxicity.
Biochemical and biophysical research communications 1991;180(2):545-51.
1991: Ulrich Brinkmann; L H Pai; David J FitzGerald; M Willingham; Ira Pastan
B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8616-20.
1991: C B Siegall; S Epstein; E Speir; timothy hla; R Forough; Thomas Maciag; David J FitzGerald; Ira Pastan
Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(13):2843-9.
1991: I H Lelong; A P Guzikowski; R P Haugland; Ira Pastan; Michael M Gottesman; M C Willingham
Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.
Molecular pharmacology 1991;40(4):490-4.
1991: G H Mickisch; Thomas Licht; G T Merlino; Michael M Gottesman; Ira Pastan
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Cancer research 1991;51(19):5417-24.
1991: S Seetharam; V K Chaudhary; D FitzGerald; Ira Pastan
Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.
The Journal of biological chemistry 1991;266(26):17376-81.
1991: C P Herbort; MD de Smet; FG Roberge; Robert B Nussenblatt; D FitzGerald; Haya Lorberboum-Galski; Ira Pastan
Treatment of corneal allograft rejection with the cytotoxin IL-2-PE40.
Transplantation 1991;52(3):470-4.
1991: Ira Pastan; M C Willingham; Michael M Gottesman
Molecular manipulations of the multidrug transporter: a new role for transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(11):2523-8.
1991: Stephen E Epstein; C B Siegall; Sadatoshi Biro; Ya-Min Fu; D FitzGerald; Ira Pastan
Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells.
Circulation 1991;84(2):778-87.
1991: G H Mickisch; Ira Pastan; Michael M Gottesman
Multidrug resistant transgenic mice as a novel pharmacologic tool.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(8):381-7.
1991: G H Mickisch; G T Merlino; P M Aiken; Michael M Gottesman; Ira Pastan
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
The Journal of urology 1991;146(2):447-53.
1991: C B Siegall; M Ogata; Ira Pastan; David J FitzGerald
Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation.
Biochemistry 1991;30(29):7154-9.
1991: Ira Pastan; E T Lovelace; M G Gallo; A V Rutherford; J L Magnani; M C Willingham
Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas.
Cancer research 1991;51(14):3781-7.
1991: Raj K Puri; M Ogata; P Leland; G M Feldman; D FitzGerald; Ira Pastan
Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin.
Cancer research 1991;51(11):3011-7.
1991: L H Pai; M G Gallo; David J FitzGerald; Ira Pastan
Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).
Cancer research 1991;51(11):2808-12.
1991: C B Siegall; Robert J Kreitman; David J FitzGerald; Ira Pastan
Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.
Cancer research 1991;51(11):2831-6.
1991: John W Rose; H Lorberboum-Galski; D Fitzgerald; R McCarron; Kenneth E Hill; Jeannette J Townsend; Ira Pastan
Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis.
Journal of neuroimmunology 1991;32(3):209-17.
1991: R Padmanabhan; T Tsuruo; S E Kane; M C Willingham; B H Howard; Michael M Gottesman; Ira Pastan
Magnetic-affinity cell sorting of human multidrug-resistant cells.
Journal of the National Cancer Institute 1991;83(8):565-9.
1991: L H Pai; Janendra Batra; David J FitzGerald; M C Willingham; Ira Pastan
Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3358-62.
1991: Janendra Batra; David J FitzGerald; V K Chaudhary; Ira Pastan
Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).
Molecular and cellular biology 1991;11(4):2200-5.
1991: E Beraud; Haya Lorberboum-Galski; Chi-Chao Chan; D FitzGerald; Ira Pastan; Robert B Nussenblatt
Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40.
Cellular immunology 1991;133(2):379-89.
1991: David C Heimbrook; S M Stirdivant; J D Ahern; N L Balishin; D R Patrick; G M Edwards; D Defeo-Jones; D J FitzGerald; Ira Pastan; Allen Oliff
Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo.
Journal of industrial microbiology 1991;7(3):203-7.
1991: T I Prior; David J FitzGerald; Ira Pastan
Barnase toxin: a new chimeric toxin composed of pseudomonas exotoxin A and barnase.
Cell 1991;64(5):1017-23.
1991: D W Shen; Y G Lu; K V Chin; Ira Pastan; Michael M Gottesman
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
Journal of cell science 1991;98 ( Pt 3)():317-22.
1991: W Debinski; C B Siegall; D Fitzgerald; Ira Pastan
Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.
Molecular and cellular biology 1991;11(3):1751-3.
1991: D FitzGerald; Ira Pastan
Redirecting Pseudomonas exotoxin.
Seminars in cell biology 1991;2(1):31-7.
1991: E P Bruggemann; V Chaudhary; Michael M Gottesman; Ira Pastan
Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein.
BioTechniques 1991;10(2):202-4, 206, 208-9.
1991: G H Mickisch; G T Merlino; H Galski; Michael M Gottesman; Ira Pastan
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):547-51.
1991: M Horio; E Lovelace; Ira Pastan; Michael M Gottesman
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Biochimica et biophysica acta 1991;1061(1):106-10.
1991: Haya Lorberboum-Galski; Robert Lafyatis; J P Case; D FitzGerald; Ronald L Wilder; Ira Pastan
Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion.
International journal of immunopharmacology 1991;13(2-3):305-15.
1991: Ira Pastan; Michael M Gottesman
Multidrug resistance.
Annual review of medicine 1991;42():277-86.
1991: H Galski; G T Merlino; Michael M Gottesman; Ira Pastan
Expression of a human multidrug-resistance cDNA (MDR1) under the control of a beta-actin promoter in transgenic mice.
Biotechnology (Reading, Mass.) 1991;16():103-24.
1991: T I Prior; Lee Helman; David J FitzGerald; Ira Pastan
Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin.
Cancer research 1991;51(1):174-80.
1991: M Ogata; Ira Pastan; D FitzGerald
Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes.
Infection and immunity 1991;59(1):407-14.
1991: M Horio; Masahiro Kakihara; H Nakahama; Y Fukuhara; N Ueda; Yoshimasa Orita; T Kamada; Ira Pastan; J Handler
Kidney-derived cells show multidrug secretory transport.
Contributions to nephrology 1991;95():143-8.
1991: L J Goldstein; Michael M Gottesman; Ira Pastan
Expression of the MDR1 gene in human cancers.
Cancer treatment and research 1991;57():101-19.
1990: C B Siegall; G Schwab; R P Nordan; David J FitzGerald; Ira Pastan
Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.
Cancer research 1990;50(24):7786-8.
1990: L H Pai; David J FitzGerald; Mark Tepper; B Schacter; G Spitalny; Ira Pastan
Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice.
Cancer research 1990;50(24):7750-3.
1990: V K Chaudhary; M G Gallo; David J FitzGerald; Ira Pastan
A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9491-4.
1990: M Ogata; V K Chaudhary; Ira Pastan; David J FitzGerald
Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol.
The Journal of biological chemistry 1990;265(33):20678-85.
1990: Robert J Kreitman; V K Chaudhary; Thomas Waldmann; M C Willingham; David J FitzGerald; Ira Pastan
The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8291-5.
1990: P Ashorn; Bernard Moss; John N Weinstein; V K Chaudhary; David J FitzGerald; Ira Pastan; Edward A Berger
Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8889-93.
1990: R W Kozak; Haya Lorberboum-Galski; L Jones; Raj K Puri; M C Willingham; T Malek; David J FitzGerald; Thomas Waldmann; Ira Pastan
IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2766-71.
1990: C B Siegall; David J FitzGerald; Ira Pastan
Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules.
Seminars in cancer biology 1990;1(5):345-50.
1990: C B Siegall; David J FitzGerald; Ira Pastan
Cytotoxicity of IL6-PE40 and derivatives on tumor cells expressing a range of interleukin 6 receptor levels.
The Journal of biological chemistry 1990;265(27):16318-23.
1990: V K Chaudhary; Y Jinno; M G Gallo; D FitzGerald; Ira Pastan
Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity.
The Journal of biological chemistry 1990;265(27):16306-10.
1990: Haya Lorberboum-Galski; R J Garsia; M Gately; P S Brown; R E Clark; Thomas Waldmann; V K Chaudhary; David J FitzGerald; Ira Pastan
IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.
The Journal of biological chemistry 1990;265(27):16311-7.
1990: Janendra Batra; D FitzGerald; M Gately; V K Chaudhary; Ira Pastan
Anti-Tac(Fv)-PE40, a single chain antibody Pseudomonas fusion protein directed at interleukin 2 receptor bearing cells.
The Journal of biological chemistry 1990;265(25):15198-202.
1990: I Sugawara; T Koji; K Ueda; Ira Pastan; Michael M Gottesman; P K Nakane; S Mori
In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA.
Japanese journal of cancer research : Gann 1990;81(9):949-55.
1990: Janendra Batra; V K Chaudhary; D FitzGerald; Ira Pastan
TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors.
Biochemical and biophysical research communications 1990;171(1):1-6.
1990: M Horio; Ira Pastan; Michael M Gottesman; J S Handler
Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.
Biochimica et biophysica acta 1990;1027(2):116-22.
1990: J R McLachlin; M A Eglitis; K Ueda; Philip W Kantoff; Ira Pastan; W French Anderson; Michael M Gottesman
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.
Journal of the National Cancer Institute 1990;82(15):1260-3.
1990: S E Kane; Ira Pastan; Michael M Gottesman
Genetic basis of multidrug resistance of tumor cells.
Journal of bioenergetics and biomembranes 1990;22(4):593-618.
1990: K V Chin; S S Chauhan; Ira Pastan; Michael M Gottesman
Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(8):361-5.
1990: Alfredo G Tomasselli; J O Hui; T K Sawyer; D J Staples; C A Bannow; I M Reardon; V K Chaudhary; C M Fryling; Ira Pastan; D J Fitzgerald
Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates.
Journal of virology 1990;64(7):3157-61.
1990: D FitzGerald; T Idziorek; Janendra Batra; M Willingham; Ira Pastan
Antitumor activity of a thioether-linked immunotoxin: OVB3-PE.
Bioconjugate chemistry 1990;1(4):264-8.
1990: David C Heimbrook; S M Stirdivant; J D Ahern; N L Balishin; D R Patrick; G M Edwards; D Defeo-Jones; D J FitzGerald; Ira Pastan; Allen Oliff
Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4697-701.
1990: J S Tyagi; Ira Pastan
Purification of calf thymus RNA polymerase II for in vitro transcription studies.
Journal of biochemical and biophysical methods 1990;21(1):1-8.
1990: C B Siegall; R P Nordan; David J FitzGerald; Ira Pastan
Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells.
Molecular and cellular biology 1990;10(6):2443-7.
1990: Edward A Berger; V K Chaudhary; K A Clouse; D Jaraquemada; J A Nicholas; K L Rubino; D J Fitzgerald; Ira Pastan; Bernard Moss
Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions.
AIDS research and human retroviruses 1990;6(6):795-804.
1990: R W Kozak; D P Fitzgerald; R W Atcher; Carolyn K Goldman; D L Nelson; Otto A Gansow; Ira Pastan; Thomas Waldmann
Selective elimination in vitro of alloresponsive T cells to human transplantation antigens by toxin or radionuclide conjugated anti-IL-2 receptor (Tac) monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3417-23.
1990: T Idziorek; D FitzGerald; Ira Pastan
Low pH-induced changes in Pseudomonas exotoxin and its domains: increased binding of Triton X-114.
Infection and immunity 1990;58(5):1415-20.
1990: F Thiebaut; S J Currier; J Whitaker; Richard P Haugland; Michael M Gottesman; Ira Pastan; M C Willingham
Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(5):685-90.
1990: J M Ford; E P Bruggemann; Ira Pastan; Michael M Gottesman; W N Hait
Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.
Cancer research 1990;50(6):1748-56.
1990: ursula germann; M C Willingham; Ira Pastan; Michael M Gottesman
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus.
Biochemistry 1990;29(9):2295-303.
1990: Y Raviv; Harvey B Pollard; E P Bruggemann; Ira Pastan; Michael M Gottesman
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.
The Journal of biological chemistry 1990;265(7):3975-80.
1990: M C Willingham; Ira Pastan
A reversible multi-well chamber for incubation of cultured cells with small volumes: application to screening of hybridoma fusions using immunofluorescence microscopy.
BioTechniques 1990;8(3):320-4.
1990: ursula germann; K V Chin; Ira Pastan; Michael M Gottesman
Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(5):1501-7.
1990: V K Chaudhary; Janendra Batra; M G Gallo; M C Willingham; David J FitzGerald; Ira Pastan
A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1066-70.
1990: P A Marino; Michael M Gottesman; Ira Pastan
Regulation of the multidrug resistance gene in regenerating rat liver.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(2):57-62.
1990: S Tanaka; S J Currier; E P Bruggemann; K Ueda; ursula germann; Ira Pastan; Michael M Gottesman
Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.
Biochemical and biophysical research communications 1990;166(1):180-6.
1990: Alfredo G Tomasselli; J O Hui; T K Sawyer; D J Staples; D J FitzGerald; V K Chaudhary; Ira Pastan; Robert L Heinrikson
Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease.
The Journal of biological chemistry 1990;265(1):408-13.
1990: C J Chen; Douglas P Clark; K Ueda; Ira Pastan; Michael M Gottesman; I B Roninson
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
The Journal of biological chemistry 1990;265(1):506-14.
1990: K V Chin; S Tanaka; G Darlington; Ira Pastan; Michael M Gottesman
Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.
The Journal of biological chemistry 1990;265(1):221-6.
1990: H Sato; Michael M Gottesman; L J Goldstein; Ira Pastan; A M Block; A A Sandberg; H D Preisler
Expression of the multidrug resistance gene in myeloid leukemias.
Leukemia research 1990;14(1):11-21.
1990: L J Goldstein; Antonio Tito Fojo; K Ueda; William M Crist; A Green; G Brodeur; Ira Pastan; Michael M Gottesman
Expression of the multidrug resistance, MDR1, gene in neuroblastomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(1):128-36.
1990: C B Siegall; David J FitzGerald; Ira Pastan
Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin.
Current topics in microbiology and immunology 1990;166():63-9.
1990: V K Chaudhary; Y Jinno; D FitzGerald; Ira Pastan
Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):308-12.
1989: S E Kane; D H Reinhard; C M Fordis; Ira Pastan; Michael M Gottesman
A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells.
Gene 1989;84(2):439-46.
1989: C B Siegall; Y H Xu; V K Chaudhary; Sankar Adhya; D Fitzgerald; Ira Pastan
Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(14):2647-52.
1989: R Kageyama; Ira Pastan
Molecular cloning and characterization of a human DNA binding factor that represses transcription.
Cell 1989;59(5):815-25.
1989: FG Roberge; Haya Lorberboum-Galski; P Le Hoang; MD de Smet; Chi-Chao Chan; D Fitzgerald; Ira Pastan
Selective immunosuppression of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3498-502.
1989: Edward A Berger; K A Clouse; V K Chaudhary; S Chakrabarti; D J FitzGerald; Ira Pastan; Bernard Moss
CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9539-43.
1989: Janendra Batra; Y Jinno; V K Chaudhary; T Kondo; M C Willingham; David J FitzGerald; Ira Pastan
Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8545-9.
1989: K Ueda; Y Yamano; Noriyuki Kioka; Yoshiyuki Kakehi; O Yoshida; Michael M Gottesman; Ira Pastan; Tohru Komano
Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay.
Japanese journal of cancer research : Gann 1989;80(11):1127-32.
1989: D FitzGerald; Ira Pastan
Targeted toxin therapy for the treatment of cancer.
Journal of the National Cancer Institute 1989;81(19):1455-63.
1989: H Galski; M Sullivan; M C Willingham; K V Chin; Michael M Gottesman; Ira Pastan; G T Merlino
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.
Molecular and cellular biology 1989;9(10):4357-63.
1989: Y Jinno; M Ogata; V K Chaudhary; M C Willingham; Sankar Adhya; D FitzGerald; Ira Pastan
Domain II mutants of Pseudomonas exotoxin deficient in translocation.
The Journal of biological chemistry 1989;264(27):15953-9.
1989: R Kageyama; G T Merlino; Ira Pastan
Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box.
The Journal of biological chemistry 1989;264(26):15508-14.
1989: J Bourhis; L J Goldstein; G Riou; Ira Pastan; Michael M Gottesman; Jean Bénard
Expression of a human multidrug resistance gene in ovarian carcinomas.
Cancer research 1989;49(18):5062-5.
1989: Ira Pastan; D FitzGerald
Pseudomonas exotoxin: chimeric toxins.
The Journal of biological chemistry 1989;264(26):15157-60.
1989: E P Bruggemann; ursula germann; Michael M Gottesman; Ira Pastan
Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.
The Journal of biological chemistry 1989;264(26):15483-8.
1989: M Horio; K V Chin; S J Currier; S Goldenberg; C Williams; Ira Pastan; Michael M Gottesman; J Handler
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.
The Journal of biological chemistry 1989;264(25):14880-4.
1989: Robert Pirker; David J FitzGerald; M Raschack; Z Frank; M C Willingham; Ira Pastan
Enhancement of the activity of immunotoxins by analogues of verapamil.
Cancer research 1989;49(17):4791-5.
1989: S J Currier; K Ueda; M C Willingham; Ira Pastan; Michael M Gottesman
Deletion and insertion mutants of the multidrug transporter.
The Journal of biological chemistry 1989;264(24):14376-81.
1989: C B Siegall; V K Chaudhary; David J FitzGerald; Ira Pastan
Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin.
The Journal of biological chemistry 1989;264(24):14256-61.
1989: S L Lai; L J Goldstein; Michael M Gottesman; Ira Pastan; C M Tsai; Bruce E Johnson; James L Mulshine; D C Ihde; K Kayser; Adi F Gazdar
MDR1 gene expression in lung cancer.
Journal of the National Cancer Institute 1989;81(15):1144-50.
1989: Noriyuki Kioka; J Tsubota; Yoshiyuki Kakehi; Tohru Komano; Michael M Gottesman; Ira Pastan; K Ueda
P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.
Biochemical and biophysical research communications 1989;162(1):224-31.
1989: P L Konen; S J Currier; A V Rutherford; Michael M Gottesman; Ira Pastan; M C Willingham
The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(7):1141-5.
1989: J W Pearson; D J FitzGerald; M C Willingham; Robert Wiltrout; Ira Pastan; Dan Longo
Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice.
Cancer research 1989;49(13):3562-7.
1989: H Kanamaru; Yoshiyuki Kakehi; O Yoshida; S Nakanishi; Ira Pastan; Michael M Gottesman
MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants.
Journal of the National Cancer Institute 1989;81(11):844-9.
1989: M Ogata; V K Chaudhary; David J FitzGerald; Ira Pastan
Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4215-9.
1989: V K Chaudhary; C Queen; Richard P. Junghans; Thomas Waldmann; David J FitzGerald; Ira Pastan
A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.
Nature 1989;339(6223):394-7.
1989: ursula germann; Michael M Gottesman; Ira Pastan
Expression of a multidrug resistance-adenosine deaminase fusion gene.
The Journal of biological chemistry 1989;264(13):7418-24.
1989: T Maekawa; F Imamoto; G T Merlino; Ira Pastan; Shunsuke Ishii
Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene.
The Journal of biological chemistry 1989;264(10):5488-94.
1989: Michael M Gottesman; Ira Pastan
Clinical trials of agents that reverse multidrug-resistance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(4):409-11.
1989: D E Banker; Ira Pastan; Michael M Gottesman; Harvey R Herschman
An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes.
Journal of cellular physiology 1989;139(1):51-7.
1989: H Lorberboum-Galski; L V Barrett; R L Kirkman; M Ogata; M C Willingham; David J FitzGerald; Ira Pastan
Cardiac allograft survival in mice treated with IL-2-PE40.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):1008-12.
1989: T J Velu; L Beguinot; William C Vass; K Zhang; Ira Pastan; Douglas Lowy
Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay.
Journal of cellular biochemistry 1989;39(2):153-66.
1989: I Nogae; Kimitoshi Kohno; J Kikuchi; Michihiko Kuwano; S Akiyama; A Kiue; K Suzuki; Y Yoshida; M M Cornwell; Ira Pastan
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein.
Biochemical pharmacology 1989;38(3):519-27.
1989: F Thiebaut; T Tsuruo; H Hamada; Michael M Gottesman; Ira Pastan; M C Willingham
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(2):159-64.
1989: Robert Pirker; L J Goldstein; H Ludwig; Werner Linkesch; C Lechner; Michael M Gottesman; Ira Pastan
Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.
Cancer communications 1989;1(2):141-4.
1989: J P Case; Haya Lorberboum-Galski; Robert Lafyatis; D FitzGerald; Ronald L Wilder; Ira Pastan
Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):287-91.
1989: R H Kurrasch; A V Rutherford; M E Rick; M G Gallo; E T Lovelace; Ira Pastan; M C Willingham
Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(1):57-67.
1988: Katsuhiko Yoshimoto; Hiroyuki Iwahana; Y Yokogoshi; S Saito; M Shiraishi; T Sekiya; Michael M Gottesman; Ira Pastan
A polymorphic HindIII site within the human multidrug resistance gene 1 (MDR1).
Nucleic acids research 1988;16(24):11850.
1988: M Ogata; Haya Lorberboum-Galski; D FitzGerald; Ira Pastan
IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4224-8.
1988: Haya Lorberboum-Galski; R W Kozak; Thomas Waldmann; P Bailon; David J FitzGerald; Ira Pastan
Interleukin 2 (IL2) PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor.
The Journal of biological chemistry 1988;263(35):18650-6.
1988: C B Siegall; V K Chaudhary; David J FitzGerald; Ira Pastan
Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9738-42.
1988: N D Richert; L Aldwin; D Nitecki; Michael M Gottesman; Ira Pastan
Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells.
Biochemistry 1988;27(20):7607-13.
1988: V K Chaudhary; T Mizukami; Thomas R Fuerst; David J FitzGerald; Bernard Moss; Ira Pastan; Edward A Berger
Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein.
Nature 1988;335(6188):369-72.
1988: Y Jinno; V K Chaudhary; T Kondo; Sankar Adhya; David J FitzGerald; Ira Pastan
Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity.
The Journal of biological chemistry 1988;263(26):13203-7.
1988: Michael M Gottesman; Ira Pastan
The multidrug transporter, a double-edged sword.
The Journal of biological chemistry 1988;263(25):12163-6.
1988: D W Shen; Ira Pastan; Michael M Gottesman
In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.
Cancer research 1988;48(15):4334-9.
1988: M G Gallo; V K Chaudhary; David J FitzGerald; M C Willingham; Ira Pastan
Cloning and expression of the H chain V region of antibody OVB3 that reacts with human ovarian cancer.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):1034-40.
1988: S E Kane; Bruce R Troen; S Gal; K Ueda; Ira Pastan; Michael M Gottesman
Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.
Molecular and cellular biology 1988;8(8):3316-21.
1988: Robert Pirker; David J FitzGerald; M C Willingham; Ira Pastan
Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines.
Cancer research 1988;48(14):3919-23.
1988: T Kondo; D FitzGerald; V K Chaudhary; Sankar Adhya; Ira Pastan
Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.
The Journal of biological chemistry 1988;263(19):9470-5.
1988: R Kageyama; G T Merlino; Ira Pastan
A transcription factor active on the epidermal growth factor receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5016-20.
1988: Y Jinno; G T Merlino; Ira Pastan
A novel effect of EGF on mRNA stability.
Nucleic acids research 1988;16(11):4957-66.
1988: F Amano; Michael M Gottesman; Ira Pastan
Epidermal growth factor-dependent growth of human KB cells in a defined medium and altered growth factor requirements of KB mutants resistant to EGF-Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):502-8.
1988: F Amano; Ira Pastan; Michael M Gottesman
Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):527-32.
1988: Ira Pastan; Michael M Gottesman; K Ueda; E Lovelace; A V Rutherford; M C Willingham
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4486-90.
1988: R Kageyama; G T Merlino; Ira Pastan
Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor.
The Journal of biological chemistry 1988;263(13):6329-36.
1988: M Horio; Michael M Gottesman; Ira Pastan
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3580-4.
1988: V K Chaudhary; Y H Xu; D FitzGerald; Sankar Adhya; Ira Pastan
Role of domain II of Pseudomonas exotoxin in the secretion of proteins into the periplasm and medium by Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):2939-43.
1988: A C Johnson; S Ishii; Y Jinno; Ira Pastan; G T Merlino
Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.
The Journal of biological chemistry 1988;263(12):5693-9.
1988: Yoshiyuki Kakehi; Hiroshi Kanamaru; O Yoshida; H Ohkubo; S Nakanishi; Michael M Gottesman; Ira Pastan
Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance.
The Journal of urology 1988;139(4):862-5.
1988: N C Popescu; Sheue-Yann Cheng; Ira Pastan
Chromosomal localization of the gene for a human thyroid hormone-binding protein.
American journal of human genetics 1988;42(4):560-4.
1988: K L Goldenthal; K Hedman; J W Chen; Thomas August; P Vihko; Ira Pastan; M C Willingham
Pre-lysosomal divergence of alpha 2-macroglobulin and transferrin: a kinetic study using a monoclonal antibody against a lysosomal membrane glycoprotein (LAMP-1).
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988;36(4):391-400.
1988: Haya Lorberboum-Galski; D FitzGerald; V Chaudhary; Sankar Adhya; Ira Pastan
Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1922-6.
1988: Michael M Gottesman; Ira Pastan
Resistance to multiple chemotherapeutic agents in human cancer cells.
Trends in pharmacological sciences 1988;9(2):54-8.
1988: S Akiyama; M M Cornwell; Michihiko Kuwano; Ira Pastan; Michael M Gottesman
Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.
Molecular pharmacology 1988;33(2):144-7.
1988: A C Johnson; Susan H Garfield; G T Merlino; Ira Pastan
Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver.
Biochemical and biophysical research communications 1988;150(1):412-8.
1988: T Obata; S Kitagawa; Q H Gong; Ira Pastan; Sheue-Yann Cheng
Thyroid hormone down-regulates p55, a thyroid hormone-binding protein that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase.
The Journal of biological chemistry 1988;263(2):782-5.
1988: Ira Pastan; Michael M Gottesman
Molecular biology of multidrug resistance in human cells.
Important advances in oncology 1988;():3-16.
1988: D J FitzGerald; M C Willingham; Ira Pastan
Pseudomonas exotoxin--immunotoxins.
Cancer treatment and research 1988;37():161-73.
1987: K Ueda; Ira Pastan; Michael M Gottesman
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.
The Journal of biological chemistry 1987;262(36):17432-6.
1987: T J Velu; L Beguinot; William C Vass; M C Willingham; G T Merlino; Ira Pastan; Douglas Lowy
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.
Science (New York, N.Y.) 1987;238(4832):1408-10.
1987: Antonio Tito Fojo; D W Shen; Lyn A Mickley; Ira Pastan; Michael M Gottesman
Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(12):1922-7.
1987: M C Willingham; N D Richert; M M Cornwell; T Tsuruo; H Hamada; Michael M Gottesman; Ira Pastan
Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(12):1451-6.
1987: F Thiebaut; T Tsuruo; H Hamada; Michael M Gottesman; Ira Pastan; M C Willingham
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7735-8.
1987: J Hwang; N Richert; Ira Pastan; Michael M Gottesman
Mutant KB cells with decreased EGF receptor expression: biochemical characterization.
Journal of cellular physiology 1987;133(1):127-34.
1987: Stanley J Cryz; Emil Fürer; J C Sadoff; R Germanier; Ira Pastan; M C Willingham; D J FitzGerald
Use of Pseudomonas aeruginosa toxin A in the construction of conjugate vaccines and immunotoxins.
Reviews of infectious diseases 1987;9 Suppl 5():S644-9.
1987: Sheue-Yann Cheng; Q H Gong; C Parkison; E A Robinson; E Appella; G T Merlino; Ira Pastan
The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.
The Journal of biological chemistry 1987;262(23):11221-7.
1987: V K Chaudhary; D J FitzGerald; S Adhya; Ira Pastan
Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(13):4538-42.
1987: M M Cornwell; T Tsuruo; Michael M Gottesman; Ira Pastan
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(1):51-4.
1987: D J FitzGerald; M C Willingham; C O Cardarelli; H Hamada; T Tsuruo; Michael M Gottesman; Ira Pastan
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4288-92.
1987: R M Lyall; J L Hwang; C Cardarelli; D FitzGerald; S Akiyama; Michael M Gottesman; Ira Pastan
Isolation of human KB cell lines resistant to epidermal growth factor-Pseudomonas exotoxin conjugates.
Cancer research 1987;47(11):2961-6.
1987: S S Thorgeirsson; B E Huber; S Sorrell; A Fojo; Ira Pastan; Michael M Gottesman
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
Science (New York, N.Y.) 1987;236(4805):1120-2.
1987: Ira Pastan; Michael M Gottesman
Multiple-drug resistance in human cancer.
The New England journal of medicine 1987;316(22):1388-93.
1987: S Gamou; J Hunts; H Harigai; S Hirohashi; Y Shimosato; Ira Pastan; N Shimizu
Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells.
Cancer research 1987;47(10):2668-73.
1987: K Ueda; C Cardarelli; Michael M Gottesman; Ira Pastan
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):3004-8.
1987: M C Willingham; D J FitzGerald; Ira Pastan
Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2474-8.
1987: S Kitagawa; T Obata; S Hasumura; Ira Pastan; S Y Cheng
A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization.
The Journal of biological chemistry 1987;262(8):3903-8.
1987: D J FitzGerald; M J Bjorn; R J Ferris; J L Winkelhake; A E Frankel; T C Hamilton; R F Ozols; M C Willingham; Ira Pastan
Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.
Cancer research 1987;47(5):1407-10.
1987: P Seth; Ira Pastan; M C Willingham
Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase.
Journal of virology 1987;61(3):883-8.
1987: M M Cornwell; Ira Pastan; Michael M Gottesman
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
The Journal of biological chemistry 1987;262(5):2166-70.
1987: K Hedman; K L Goldenthal; A V Rutherford; Ira Pastan; M C Willingham
Comparison of the intracellular pathways of transferrin recycling and vesicular stomatitis virus membrane glycoprotein exocytosis by ultrastructural double-label cytochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(2):233-43.
1987: J Hwang; D J Fitzgerald; S Adhya; Ira Pastan
Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.
Cell 1987;48(1):129-36.
1987: K Ueda; Douglas P Clark; C J Chen; I B Roninson; Michael M Gottesman; Ira Pastan
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.
The Journal of biological chemistry 1987;262(2):505-8.
1987: Antonio Tito Fojo; M Cornwell; C Cardarelli; Douglas P Clark; N Richert; D W Shen; K Ueda; M Willingham; Michael M Gottesman; Ira Pastan
Molecular biology of drug resistance.
Breast cancer research and treatment 1987;9(1):5-16.
1987: A T Fojo; K Ueda; Dennis J Slamon; David G Poplack; Michael M Gottesman; Ira Pastan
Expression of a multidrug-resistance gene in human tumors and tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):265-9.
1986: K Ueda; M M Cornwell; Michael M Gottesman; Ira Pastan; I B Roninson; V Ling; John R Riordan
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
Biochemical and biophysical research communications 1986;141(3):956-62.
1986: John Hanover; P D'Souza; Thomas J August; Ira Pastan; M C Willingham
Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit alpha 2-macroglobulin binding and uptake.
The Journal of biological chemistry 1986;261(35):16732-7.
1986: Ira Pastan; M C Willingham; D J FitzGerald
Immunotoxins.
Cell 1986;47(5):641-8.
1986: S Hasumura; S Kitagawa; E Lovelace; M C Willingham; Ira Pastan; S Cheng
Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies.
Biochemistry 1986;25(24):7881-8.
1986: C J Chen; J E Chin; K Ueda; Douglas P Clark; Ira Pastan; Michael M Gottesman; I B Roninson
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
Cell 1986;47(3):381-9.
1986: D W Shen; Antonio Tito Fojo; Igor B Roninson; J E Chin; R Soffir; Ira Pastan; Michael M Gottesman
Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
Molecular and cellular biology 1986;6(11):4039-45.
1986: M C Willingham; M M Cornwell; C O Cardarelli; Michael M Gottesman; Ira Pastan
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Cancer research 1986;46(11):5941-6.
1986: J Hunts; G Merlino; Ira Pastan; N Shimizu
Reduction of EGF receptor synthesis by antisense RNA vectors.
FEBS letters 1986;206(2):319-22.
1986: D J FitzGerald; M C Willingham; Ira Pastan
Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6627-30.
1986: A J Clark; L Beguinot; S Ishii; D P Ma; B A Roe; G T Merlino; Ira Pastan
Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA.
Biochimica et biophysica acta 1986;867(4):244-51.
1986: K Hedman; Ira Pastan; M C Willingham
The organelles of the trans domain of the cell. Ultrastructural localization of sialoglycoconjugates using Limax flavus agglutinin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1986;34(8):1069-77.
1986: A Fojo; R Lebo; N Shimizu; J E Chin; Igor B Roninson; G T Merlino; Michael M Gottesman; Ira Pastan
Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
Somatic cell and molecular genetics 1986;12(4):415-20.
1986: J Hwang; J Pouyssegur; M C Willingham; Ira Pastan
The role of intracellular pH in ligand internalization.
Journal of cellular physiology 1986;128(1):18-22.
1986: M M Cornwell; Michael M Gottesman; Ira Pastan
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.
The Journal of biological chemistry 1986;261(17):7921-8.
1986: D W Shen; C Cardarelli; J Hwang; M Cornwell; N Richert; S Ishii; Ira Pastan; Michael M Gottesman
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
The Journal of biological chemistry 1986;261(17):7762-70.
1986: S Ishii; J T Kadonaga; Robert Tjian; J N Brady; G T Merlino; Ira Pastan
Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter.
Science (New York, N.Y.) 1986;232(4756):1410-3.
1986: Igor B Roninson; J E Chin; K G Choi; P Gros; D E Housman; Antonio Tito Fojo; D W Shen; Michael M Gottesman; Ira Pastan
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4538-42.
1986: M M Cornwell; A R Safa; R L Felsted; Michael M Gottesman; Ira Pastan
Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3847-50.
1986: D W Shen; Antonio Tito Fojo; J E Chin; Igor B Roninson; N Richert; Ira Pastan; Michael M Gottesman
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
Science (New York, N.Y.) 1986;232(4750):643-5.
1986: R Blumenthal; P Seth; M C Willingham; Ira Pastan
pH-dependent lysis of liposomes by adenovirus.
Biochemistry 1986;25(8):2231-7.
1986: A Levitzki; J Rudick; Ira Pastan; W C Vass; Douglas Lowy
Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes.
FEBS letters 1986;197(1-2):134-8.
1986: L Beguinot; D Werth; S Ito; N Richert; M C Willingham; Ira Pastan
Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor.
The Journal of biological chemistry 1986;261(4):1801-7.
1986: S Y Cheng; S Hasumura; M C Willingham; Ira Pastan
Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):947-51.
1986: T Yamamoto; N Kamata; H Kawano; S Shimizu; T Kuroki; K Toyoshima; K Rikimaru; N Nomura; R Ishizaki; Ira Pastan
High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.
Cancer research 1986;46(1):414-6.
1985: S Hasumura; S Kitagawa; Ira Pastan; S Y Cheng
Solubilization and characterization of a membrane 3, 3', 5-triiodo-L-thyronine binding protein from rat pituitary tumor GH3 cells.
Biochemical and biophysical research communications 1985;133(3):837-43.
1985: S Ishii; G T Merlino; Ira Pastan
Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter.
Science (New York, N.Y.) 1985;230(4732):1378-81.
1985: John Hanover; L Beguinot; M C Willingham; Ira Pastan
Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.
The Journal of biological chemistry 1985;260(29):15938-45.
1985: C R King; M H Kraus; L T Williams; G T Merlino; Ira Pastan; S A Aaronson
Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs.
Nucleic acids research 1985;13(23):8477-86.
1985: A J Clark; S Ishii; N Richert; G T Merlino; Ira Pastan
Epidermal growth factor regulates the expression of its own receptor.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8374-8.
1985: K L Goldenthal; Ira Pastan; M C Willingham
Serial section analysis of clathrin-coated pits in rat liver sinusoidal endothelial cells.
Experimental cell research 1985;161(2):342-52.
1985: Prem Seth; M C Willingham; Ira Pastan
Binding of adenovirus and its external proteins to Triton X-114. Dependence on pH.
The Journal of biological chemistry 1985;260(27):14431-4.
1985: J S Tyagi; H Hirano; Ira Pastan
Modulation of fibronectin gene activity in chick embryo fibroblasts transformed by a temperature-sensitive strain (ts68) of Rous sarcoma virus.
Nucleic acids research 1985;13(22):8275-84.
1985: T J Singh; J Hochman; Roberto Verna; M Chapman; I Abraham; Ira Pastan; Michael M Gottesman
Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase.
The Journal of biological chemistry 1985;260(26):13927-33.
1985: A T Fojo; J Whang-Peng; Michael M Gottesman; Ira Pastan
Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7661-5.
1985: R Pirker; D J FitzGerald; T C Hamilton; R F Ozols; W Laird; A E Frankel; M C Willingham; Ira Pastan
Characterization of immunotoxins active against ovarian cancer cell lines.
The Journal of clinical investigation 1985;76(3):1261-7.
1985: J H Hunts; N Shimizu; T Yamamoto; K Toyoshima; G T Merlino; Y H Xu; Ira Pastan
Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA.
Somatic cell and molecular genetics 1985;11(5):477-84.
1985: J Le Pendu; P Fredman; N D Richter; J L Magnani; M C Willingham; Ira Pastan; R Oriol; V Ginsburg
Monoclonal antibody 101 that precipitates the glycoprotein receptor for epidermal growth factor is directed against the Y antigen, not the H type 1 antigen.
Carbohydrate research 1985;141(2):347-9.
1985: Prem Seth; Ira Pastan; M C Willingham
Adenovirus-dependent increase in cell membrane permeability.
The Journal of biological chemistry 1985;260(17):9598-602.
1985: J Hunts; M Ueda; S Ozawa; O Abe; Ira Pastan; N Shimizu
Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomas.
Japanese journal of cancer research : Gann 1985;76(8):663-6.
1985: S Ishii; Y H Xu; R H Stratton; B A Roe; G T Merlino; Ira Pastan
Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(15):4920-4.
1985: A Fojo; S Akiyama; Michael M Gottesman; Ira Pastan
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.
Cancer research 1985;45(7):3002-7.
1985: J W Chen; T L Murphy; M C Willingham; Ira Pastan; Thomas J August
Identification of two lysosomal membrane glycoproteins.
The Journal of cell biology 1985;101(1):85-95.
1985: Ralph Alderson; Ira Pastan; S Cheng
Characterization of the 3,3',5-triiodo-L-thyronine-binding site on plasma membranes from human placenta.
Endocrinology 1985;116(6):2621-30.
1985: K T Yu; D K Werth; Ira Pastan; M P Czech
src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.
The Journal of biological chemistry 1985;260(9):5838-46.
1985: L Beguinot; John Hanover; S Ito; N D Richert; M C Willingham; Ira Pastan
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2774-8.
1985: N Richert; S Akiyama; D Shen; Michael M Gottesman; Ira Pastan
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2330-3.
1985: John Hanover; Ira Pastan; M C Willingham
Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts.
Experimental cell research 1985;157(1):276-81.
1985: S Akiyama; A Fojo; John Hanover; Ira Pastan; Michael M Gottesman
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somatic cell and molecular genetics 1985;11(2):117-26.
1985: G T Merlino; Y H Xu; N Richert; A J Clark; S Ishii; S Banks-Schlegel; Ira Pastan
Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line.
The Journal of clinical investigation 1985;75(3):1077-9.
1985: S Akiyama; Prem Seth; R Pirker; D FitzGerald; Michael M Gottesman; Ira Pastan
Potentiation of cytotoxic activity of immunotoxins on cultured human cells.
Cancer research 1985;45(3):1005-7.
1985: N Perrotti; S I Taylor; N D Richert; U R Rapp; Ira Pastan; J Roth
Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.
Science (New York, N.Y.) 1985;227(4688):761-3.
1985: R Pirker; D J FitzGerald; T C Hamilton; R F Ozols; M C Willingham; Ira Pastan
Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.
Cancer research 1985;45(2):751-7.
1985: Ira Pastan; J Hanover; M Willingham
The cellular entry of EGF and transferrin: a problem in intracellular sorting.
Current topics in cellular regulation 1985;26():17-25.
1985: R M Lyall; Ira Pastan; M C Willingham
EGF induces receptor down-regulation with no receptor recycling in KB cells.
Journal of cellular physiology 1985;122(1):166-70.
1985: R B Dickson; John Hanover; Ira Pastan; M C Willingham
Isolation of receptosomes (endosomes) from human KB cells.
Methods in enzymology 1985;109():257-71.
1985: M C Willingham; Ira Pastan
Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1985;33(1):59-64.
1984: P Seth; M C Willingham; Ira Pastan
Adenovirus-dependent release of 51Cr from KB cells at an acidic pH.
The Journal of biological chemistry 1984;259(23):14350-3.
1984: John Hanover; M C Willingham; Ira Pastan
Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes.
Cell 1984;39(2 Pt 1):283-93.
1984: Michael M Gottesman; C Roth; G Vlahakis; Ira Pastan
Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.
Molecular and cellular biology 1984;4(12):2639-42.
1984: Y H Xu; N Richert; S Ito; G T Merlino; Ira Pastan
Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7308-12.
1984: S Hasumura; B Rossi; Ralph Alderson; Ira Pastan; S Cheng
Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity.
Biochemical and biophysical research communications 1984;124(3):956-62.
1984: T Akiyama; Y Yamada; H Ogawara; N Richert; Ira Pastan; T Yamamoto; M Kasuga
Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor.
Biochemical and biophysical research communications 1984;123(2):797-802.
1984: D J FitzGerald; Thomas Waldmann; M C Willingham; Ira Pastan
Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.
The Journal of clinical investigation 1984;74(3):966-71.
1984: Prem Seth; D J Fitzgerald; M C Willingham; Ira Pastan
Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate.
Journal of virology 1984;51(3):650-5.
1984: S Akiyama; Michael M Gottesman; John Hanover; D J Fitzgerald; M C Willingham; Ira Pastan
Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin.
Journal of cellular physiology 1984;120(3):271-9.
1984: Prem Seth; D Fitzgerald; H Ginsberg; M Willingham; Ira Pastan
Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor.
Molecular and cellular biology 1984;4(8):1528-33.
1984: Y H Xu; S Ishii; A J Clark; M Sullivan; R K Wilson; D P Ma; B A Roe; G T Merlino; Ira Pastan
Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.
Nature 1984;309(5971):806-10.
1984: K L Goldenthal; Ira Pastan; M C Willingham
Initial steps in receptor-mediated endocytosis. The influence of temperature on the shape and distribution of plasma membrane clathrin-coated pits in cultured mammalian cells.
Experimental cell research 1984;152(2):558-64.
1984: G T Merlino; Y H Xu; S Ishii; A J Clark; K Semba; K Toyoshima; T Yamamoto; Ira Pastan
Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.
Science (New York, N.Y.) 1984;224(4647):417-9.
1984: C McKeon; Ira Pastan; B de Crombrugghe
DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern.
Nucleic acids research 1984;12(8):3491-502.
1984: D K Werth; Ira Pastan
Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.
The Journal of biological chemistry 1984;259(8):5264-70.
1984: L Beguinot; R M Lyall; M C Willingham; Ira Pastan
Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(8):2384-8.
1984: M C Willingham; C D Strader; R J Lefkowitz; Ira Pastan
Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes.
Experimental cell research 1984;151(2):573-7.
1984: M C Willingham; Ira Pastan
Endocytosis and membrane traffic in cultured cells.
Recent progress in hormone research 1984;40():569-87.
1984: M C Willingham; Ira Pastan
Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells.
International review of cytology 1984;92():51-92.
1984: M C Willingham; John Hanover; R B Dickson; Ira Pastan
Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(1):175-9.
1984: M F White; D K Werth; Ira Pastan; C R Kahn
Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src.
Journal of cellular biochemistry 1984;26(3):169-79.
1983: S Ito; D K Werth; N D Richert; Ira Pastan
Vinculin phosphorylation by the src kinase. Interaction of vinculin with phospholipid vesicles.
The Journal of biological chemistry 1983;258(23):14626-31.
1983: John Hanover; J E Rudick; M C Willingham; Ira Pastan
Alpha 2-macroglobulin binding to cultured fibroblasts: identification by affinity chromatography of high-affinity binding sites.
Archives of biochemistry and biophysics 1983;227(2):570-9.
1983: R B Dickson; John Hanover; M C Willingham; Ira Pastan
Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis.
Biochemistry 1983;22(24):5667-74.
1983: M C Willingham; S P Banks-Schlegel; Ira Pastan
Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of murine sarcoma virus.
Experimental cell research 1983;149(1):141-9.
1983: D K Werth; J E Niedel; Ira Pastan
Vinculin, a cytoskeletal substrate of protein kinase C.
The Journal of biological chemistry 1983;258(19):11423-6.
1983: P Fredman; N D Richert; J L Magnani; M C Willingham; Ira Pastan; V Ginsburg
A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen.
The Journal of biological chemistry 1983;258(18):11206-10.
1983: C W Roth; N D Richert; Ira Pastan; Michael M Gottesman
Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.
The Journal of biological chemistry 1983;258(17):10768-73.
1983: R B Dickson; L Beguinot; John Hanover; N D Richert; M C Willingham; Ira Pastan
Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(17):5335-9.
1983: M C Willingham; Ira Pastan
Formation of receptosomes from plasma membrane coated pits during endocytosis: analysis by serial sections with improved membrane labeling and preservation techniques.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5617-21.
1983: G T Merlino; C McKeon; B de Crombrugghe; Ira Pastan
Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development.
The Journal of biological chemistry 1983;258(16):10041-8.
1983: N D Richert; M C Willingham; Ira Pastan
Epidermal growth factor receptor. Characterization of a monoclonal antibody specific for the receptor of A431 cells.
The Journal of biological chemistry 1983;258(14):8902-7.
1983: D J FitzGerald; I S Trowbridge; Ira Pastan; M C Willingham
Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4134-8.
1983: M C Willingham; H T Haigler; David J FitzGerald; M G Gallo; A V Rutherford; Ira Pastan
The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling.
Experimental cell research 1983;146(1):163-75.
1983: J S Tyagi; H Hirano; G T Merlino; Ira Pastan
Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.
The Journal of biological chemistry 1983;258(9):5787-93.
1983: J M Mato; D Pencev; G Vasanthakumar; E Schiffmann; Ira Pastan
Inhibitors of endocytosis perturb phospholipid metabolism in rabbit neutrophils and other cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(7):1929-32.
1983: M C Willingham; J Wehland; C B Klee; N D Richert; A V Rutherford; Ira Pastan
Ultrastructural immunocytochemical localization of calmodulin in cultured cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(4):445-61.
1983: S Cheng; G T Merlino; Ira Pastan
A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates.
Nucleic acids research 1983;11(3):659-69.
1983: R Schlegel; T S Tralka; M C Willingham; Ira Pastan
Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site?
Cell 1983;32(2):639-46.
1983: D J FitzGerald; R Padmanabhan; Ira Pastan; M C Willingham
Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis.
Cell 1983;32(2):607-17.
1983: John Hanover; S Cheng; M C Willingham; Ira Pastan
alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites.
The Journal of biological chemistry 1983;258(1):370-7.
1983: M C Willingham; Ira Pastan
Image intensification techniques for detection of proteins in cultured cells.
Methods in enzymology 1983;98():266-83, 635.
1983: H Hirano; Y Yamada; M Sullivan; B de Crombrugghe; Ira Pastan; K M Yamada
Isolation of genomic DNA clones spanning the entire fibronectin gene.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(1):46-50.
1983: M C Willingham; Ira Pastan; G G Sahagian
Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1983;31(1):1-11.
1983: John Hanover; M C Willingham; Ira Pastan
Receptor-mediated endocytosis of alpha 2-macroglobulin: solubilization and partial purification of the fibroblast alpha 2-macroglobulin receptor.
Annals of the New York Academy of Sciences 1983;421():410-23.
1982: R B Dickson; R Schlegel; M C Willingham; Ira Pastan
Involvement of Na+ and HCO-3 in receptor-mediated endocytosis of alpha 2-macroglobulin, epidermal growth factor, and vesicular stomatitis virus.
Journal of cellular physiology 1982;113(3):353-8.
1982: J S Tyagi; G T Merlino; B de Crombrugghe; Ira Pastan
Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.
The Journal of biological chemistry 1982;257(21):13001-8.
1982: C M Gorman; G T Merlino; M C Willingham; Ira Pastan; B H Howard
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(22):6777-81.
1982: R B Dickson; R Schlegel; M C Willingham; Ira Pastan
Binding and internalization of alpha 2-microglobulin by cultured fibroblasts. Effects of monovalent ionophores.
Experimental cell research 1982;142(1):127-40.
1982: R Schlegel; M C Willingham; Ira Pastan
Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells.
Journal of virology 1982;43(3):871-5.
1982: R Horiuchi; M L Johnson; M C Willingham; Ira Pastan; S Cheng
Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5527-31.
1982: D P Via; M C Willingham; Ira Pastan; A M Gotto; Louis C Smith
Co-clustering and internalization of low-density lipoproteins and alpha 2-macroglobulin in human skin fibroblasts.
Experimental cell research 1982;141(1):15-22.
1982: S Ito; N Richert; Ira Pastan
Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4628-31.
1982: S Ito; N Richert; Ira Pastan
Vinculin phosphorylation by the src kinase: inhibition by chlorpromazine, imipramine and local anesthetics.
Biochemical and biophysical research communications 1982;107(2):670-5.
1982: M C Willingham; Ira Pastan
Transit of epidermal growth factor through coated pits of the Golgi system.
The Journal of cell biology 1982;94(1):207-12.
1982: R B Dickson; R Schlegel; M C Willingham; Ira Pastan
Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts.
Experimental cell research 1982;140(1):215-25.
1982: G T Merlino; J S Tyagi; B de Crombrugghe; Ira Pastan
Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts.
The Journal of biological chemistry 1982;257(12):7254-61.
1982: N D Richert; D L Blithe; Ira Pastan
Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors.
The Journal of biological chemistry 1982;257(12):7143-50.
1982: D L Blithe; N D Richert; Ira Pastan
Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor.
The Journal of biological chemistry 1982;257(12):7135-42.
1982: C McKeon; H Ohkubo; Ira Pastan; B de Crombrugghe
Unusual methylation pattern of the alpha 2 (l) collagen gene.
Cell 1982;29(1):203-10.
1982: J Wehland; M C Willingham; M G Gallo; Ira Pastan
The morphologic pathway of exocytosis of the vesicular stomatitis virus G protein in cultured fibroblasts.
Cell 1982;28(4):831-41.
1982: C W Roth; T Singh; Ira Pastan; Michael M Gottesman
Rous sarcoma virus transformed cells are resistant to cyclic AMP.
Journal of cellular physiology 1982;111(1):42-8.
1982: R Schlegel; R B Dickson; M C Willingham; Ira Pastan
Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2291-5.
1982: R Horiuchi; S Y Cheng; M Willingham; Ira Pastan
Inhibition of the nuclear entry of 3,3',5'-triiodo-L-thyronine by monodansylcadaverine in GH3 cells.
The Journal of biological chemistry 1982;257(6):3139-44.
1982: P J Davies; Y Shizuta; Ira Pastan
Purification and properties of avian and mammalian filamins.
Methods in enzymology 1982;85 Pt B():322-8.
1982: J Wehland; M C Willingham; M G Gallo; A V Rutherford; J Rudick; R B Dickson; Ira Pastan
Microinjection of anticlathrin antibodies into cultured fibroblasts: clathrin-coated structures in receptor-mediated endocytosis and in exocytosis.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 2():743-53.
1982: Ira Pastan; M Willingham; B de Crombrugghe; Michael M Gottesman
Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity.
National Cancer Institute monograph 1982;60():7-15.
1982: R B Dickson; M C Willingham; Ira Pastan
Receptor-mediated endocytosis of alpha 2-macroglobulin: inhibition by ionophores and stimulation by Na+ and HCO3(-).
Annals of the New York Academy of Sciences 1982;401():38-49.
1981: G T Merlino; G Vogeli; T Yamamoto; B de Crombrugghe; Ira Pastan
Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene.
The Journal of biological chemistry 1981;256(21):11251-8.
1981: M C Willingham; S S Yamada; P J Bechtel; A V Rutherford; Ira Pastan
Ultrastructural immunocytochemical localization of myosin in cultured fibroblastic cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(11):1289-301.
1981: M C Willingham; Ira Pastan; G G Sahagian; George W Jourdian; Elizabeth F Neufeld
Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6967-71.
1981: Ira Pastan; M C Willingham
Journey to the center of the cell: role of the receptosome.
Science (New York, N.Y.) 1981;214(4520):504-9.
1981: R Schlegel; M Willingham; Ira Pastan
Monensin blocks endocytosis of vesicular stomatitis virus.
Biochemical and biophysical research communications 1981;102(3):992-8.
1981: G Vogeli; H Ohkubo; M E Sobel; Y Yamada; Ira Pastan; B de Crombrugghe
Structure of the promoter for chicken alpha 2 type I collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5334-8.
1981: F R Maxfield; M C Willingham; H T Haigler; P Dragsten; Ira Pastan
Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin.
Biochemistry 1981;20(18):5353-8.
1981: M C Willingham; A V Rutherford; M G Gallo; J Wehland; R B Dickson; R Schlegel; Ira Pastan
Receptor-mediated endocytosis in cultured fibroblasts: cryptic coated pits and the formation of receptosomes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(9):1003-13.
1981: V Macchia; G Caputo; E Mandato; A Rocino; S Adhya; Ira Pastan
Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase.
Journal of bacteriology 1981;147(3):931-4.
1981: L A Dickson; Y Ninomiya; M P Bernard; D M Pesciotta; J Parsons; G Green; E F Eikenberry; B de Crombrugghe; G Vogeli; Ira Pastan; P P Fietzek; B R Olsen
The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene.
The Journal of biological chemistry 1981;256(16):8407-15.
1981: J Wehland; M C Willingham; R Dickson; Ira Pastan
Microinjection of anticlathrin antibodies into fibroblasts does not interfere with the receptor-mediated endocytosis of alpha2-macroglobulin.
Cell 1981;25(1):105-19.
1981: A LeCam; Michael M Gottesman; Ira Pastan
Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1981;675(1):94-100.
1981: H T Pretorius; P K Nandi; R E Lippoldt; M L Johnson; J H Keen; Ira Pastan; H Edelhoch
Molecular characterization of human clathrin.
Biochemistry 1981;20(10):2777-82.
1981: M R Sobel; T Yamamoto; B de Crombrugghe; Ira Pastan
Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts.
Biochemistry 1981;20(9):2678-84.
1981: R B Dickson; M C Willingham; M Gallo; Ira Pastan
Inhibition by bacitracin of high affinity binding of 125I-alpha 2M to plasma membranes.
FEBS letters 1981;126(2):265-8.
1981: R B Dickson; M C Willingham; Ira Pastan
Binding and internalization of 125I-alpha 2-macroglobulin by cultured fibroblasts.
The Journal of biological chemistry 1981;256(7):3454-9.
1981: M C Willingham; J H Keen; Ira Pastan
Ultrastructural immunocytochemical localization of clathrin in cultured fibroblasts.
Experimental cell research 1981;132(2):329-38.
1981: R B Dickson; M C Willingham; Ira Pastan
alpha 2-macroglobulin adsorbed to colloidal gold: a new probe in the study of receptor-mediated endocytosis.
The Journal of cell biology 1981;89(1):29-34.
1981: R B Dickson; J C Nicolas; M C Willingham; Ira Pastan
Internalization of alpha 2 macroglobulin in receptosomes. Studies with monovalent electron microscopic markers.
Experimental cell research 1981;132(2):488-93.
1981: enrico vittorio avvedimento; Y Yamada; E Lovelace; G Vogeli; B de Crombrugghe; Ira Pastan
Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts.
Nucleic acids research 1981;9(5):1123-31.
1981: J H Keen; M C Willingham; Ira Pastan
Clathrin and coated vesicle proteins Immunological characterization.
The Journal of biological chemistry 1981;256(5):2538-44.
1981: A LeCam; J C Nicolas; T J Singh; F Cabral; Ira Pastan; Michael M Gottesman
Cyclic AMP-dependent phosphorylation in intact cells and in cell-free extracts from Chinese hamster ovary cells. Studies with wild type and cyclic AMP-resistant mutants.
The Journal of biological chemistry 1981;256(2):933-41.
1981: T J Singh; C Roth; Michael M Gottesman; Ira Pastan
Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.
The Journal of biological chemistry 1981;256(2):926-32.
1981: J B Fagan; M E Sobel; K M Yamada; B de Crombrugghe; Ira Pastan
Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA.
The Journal of biological chemistry 1981;256(1):520-5.
1981: F R Maxfield; M C Willingham; Ira Pastan; P Dragsten; S Y Cheng
Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine.
Science (New York, N.Y.) 1981;211(4477):63-5.
1981: M C Willingham; S S Yamada; P J Davies; A V Rutherford; M G Gallo; Ira Pastan
Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(1):17-37.
1981: Ira Pastan; M C Willingham
The internalization of insulin and other hormones by fibroblastic cells.
Diabetes care 1981;4(1):33-7.
1981: G Vogeli; H Ohkubo; enrico vittorio avvedimento; M Sullivan; Y Yamada; maria mudryj; Ira Pastan; B de Crombrugghe
A repetitive structure in the chick alpha 2-collagen gene.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 2():777-83.
1981: Ira Pastan; M C Willingham
Receptor-mediated endocytosis of hormones in cultured cells.
Annual review of physiology 1981;43():239-50.
1980: Y Yamada; enrico vittorio avvedimento; maria mudryj; H Ohkubo; G Vogeli; M Irani; Ira Pastan; B de Crombrugghe
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp.
Cell 1980;22(3):887-92.
1980: H Ohkubo; G Vogeli; maria mudryj; enrico vittorio avvedimento; M Sullivan; Ira Pastan; B de Crombrugghe
Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(12):7059-63.
1980: T Yamamoto; B de Crombrugghe; Ira Pastan
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
Cell 1980;22(3):787-97.
1980: enrico vittorio avvedimento; G Vogeli; Y Yamada; J V Maizel; Ira Pastan; B de Crombrugghe
Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA.
Cell 1980;21(3):689-96.
1980: A LeCam; Michael M Gottesman; Ira Pastan
Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach.
The Journal of biological chemistry 1980;255(17):8103-8.
1980: T Yamamoto; J S Tyagi; J B Fagan; G Jay; B deCrombrugghe; Ira Pastan
Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones.
Journal of virology 1980;35(2):436-43.
1980: M C Willingham; F R Maxfield; Ira Pastan
Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1980;28(8):818-23.
1980: M C Willingham; Ira Pastan
The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts.
Cell 1980;21(1):67-77.
1980: P G Milhaud; P J Davies; Ira Pastan; Michael M Gottesman
Regulation of transglutaminase activity in Chinese hamster ovary cells.
Biochimica et biophysica acta 1980;630(4):476-84.
1980: J B Fagan; Ira Pastan; B de Crombrugghe
Sequence rearrangement and duplication of double stranded fibronectin cDNA probably occurring during cDNA synthesis by AMV reverse transcriptase and Escherichia coli DNA polymerase I.
Nucleic acids research 1980;8(13):3055-64.
1980: S Y Cheng; F R Maxfield; J Robbins; M C Willingham; Ira Pastan
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3425-9.
1980: H T Haigler; M C Willingham; Ira Pastan
Inhibitors of 125I-epidermal growth factor internalization.
Biochemical and biophysical research communications 1980;94(2):630-7.
1980: P J Davies; R Chabay; L Zech; M Berman; Ira Pastan
Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts.
Biochimica et biophysica acta 1980;629(2):282-91.
1980: M C Willingham; S S Yamada; Ira Pastan
Ultrastructural localization of tubulin in cultured fibroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1980;28(5):453-61.
1980: A Levitzki; M Willingham; Ira Pastan
Evidence for participation of transglutaminase in receptor-mediated endocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(5):2706-10.
1980: G Vogeli; enrico vittorio avvedimento; M Sullivan; J V Maizel; G Lozano; S L Adams; Ira Pastan; B de Crombrugghe
Isolation and characterization of genomic DNA coding for alpha 2 type I collagen.
Nucleic acids research 1980;8(8):1823-37.
1980: P J Davies; David Wallach; M Willingham; Ira Pastan; M S Lewis
Self-association of chicken gizzard filamin and heavy merofilamin.
Biochemistry 1980;19(7):1366-72.
1980: M C Willingham; Ira Pastan; T Y Shih; E M Scolnick
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry.
Cell 1980;19(4):1005-14.
1980: T Yamamoto; M E Sobel; S L Adams; enrico vittorio avvedimento; R DiLauro; Ira Pastan; B de Crombrugghe; A Showalter; D Pesciotta; P Fietzek; B Olsen
Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.
The Journal of biological chemistry 1980;255(6):2612-5.
1980: A M Showalter; D M Pesciotta; E F Eikenberry; T Yamamoto; Ira Pastan; B DeCrombrugghe; P P Fietzek; B R Olsen
Nucleotide sequence of a collagen cDNA-fragment coding for the carboxyl end of pro alpha 1(I)-chains.
FEBS letters 1980;111(1):61-5.
1980: H T Haigler; F R Maxfield; M C Willingham; Ira Pastan
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.
The Journal of biological chemistry 1980;255(4):1239-41.
1980: P J Davies; D R Davies; A Levitzki; F R Maxfield; P Milhaud; M C Willingham; Ira Pastan
Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.
Nature 1980;283(5743):162-7.
1980: Ira Pastan; G Jay; N Richert; P J Davies; M Willingham
Nature and intracellular location of the product of the src gene of avian sarcoma virus.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1023-9.
1980: Michael M Gottesman; A LeCam; M Bukowski; Ira Pastan
Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP.
Somatic cell genetics 1980;6(1):45-61.
1980: T Yamamoto; G Jay; Ira Pastan
Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):176-80.
1979: F R Maxfield; P J Davies; L Klempner; M C Willingham; Ira Pastan
Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5731-5.
1979: N Richert; P J Davies; G Jay; Ira Pastan
Inhibition of the transformation-specific kinase in ASV-transformed cells by N-alpha-tosyl-L-lysyl chloromethyl ketone.
Cell 1979;18(2):369-74.
1979: L Moore; Ira Pastan
A calcium requirement for movement of cultured cells.
Journal of cellular physiology 1979;101(1):101-8.
1979: L Moore; Ira Pastan
Effect of cell density on energy-dependent calcium uptake by Balb/c 3T3 membranes is independent of protein synthesis and attachment to substratum.
Journal of cellular physiology 1979;101(1):109-16.
1979: M C Willingham; G Jay; Ira Pastan
Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry.
Cell 1979;18(1):125-34.
1979: M C Willingham; F R Maxfield; Ira Pastan
alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions.
The Journal of cell biology 1979;82(3):614-25.
1979: N D Richert; P J Davies; G Jay; Ira Pastan
Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts.
Journal of virology 1979;31(3):696-706.
1979: J B Fagan; K M Yamada; B de Crombrugghe; Ira Pastan
Partial purification and characterization of the messenger RNA for cell fibronectin.
Nucleic acids research 1979;6(11):3471-80.
1979: D Evain; Michael M Gottesman; Ira Pastan; W B Anderson
A mutation affecting the catalytic subunit of cyclic AMP-dependent protein kinase in CHO cells.
The Journal of biological chemistry 1979;254(15):6931-7.
1979: J Pouysségur; Ira Pastan
The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness.
Experimental cell research 1979;121(2):373-82.
1979: S L Adams; J C Alwine; B de Crombrugghe; Ira Pastan
Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts.
The Journal of biological chemistry 1979;254(12):4935-8.
1979: W B Anderson; M Gallo; J Wilson; E Lovelace; Ira Pastan
Effect of epidermal growth factor on prostaglandin E1-stimulated accumulation of cyclic AMP in fibroblastic cells.
FEBS letters 1979;102(2):329-32.
1979: A LeCam; F Maxfield; M Willingham; Ira Pastan
Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization.
Biochemical and biophysical research communications 1979;88(3):873-81.
1979: S Cheng; N L Eberhardt; J Robbins; J D Baxter; Ira Pastan
Fluorescent rhodamine-labeled thyroid hormone derivatives: synthesis and binding to the thyroid hormone nuclear receptor.
FEBS letters 1979;100(1):113-6.
1979: F R Maxfield; M C Willingham; P J Davies; Ira Pastan
Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface.
Nature 1979;277(5698):661-3.
1979: J H Keen; M C Willingham; Ira Pastan
Clathrin-coated vesicles: isolation, dissociation and factor-dependent reassociation of clathrin baskets.
Cell 1979;16(2):303-12.
1979: R P Shiu; Ira Pastan
Properties and purification of a glucose-regulated protein from chick embryo fibroblasts.
Biochimica et biophysica acta 1979;576(1):141-50.
1979: Ira Pastan
Cell transformation.
Methods in enzymology 1979;58():368-70.
1978: M E Sobel; T Yamamoto; S L Adams; R DiLauro; enrico vittorio avvedimento; B de Crombrugghe; Ira Pastan
Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(12):5846-50.
1978: Giovanni Colonna; S S Alexander; K M Yamada; Ira Pastan; H Edelhoch
The stability of cell surface protein to surfactants and denaturants.
The Journal of biological chemistry 1978;253(21):7787-90.
1978: J Schlessinger; Y Shechter; P Cuatrecasas; M C Willingham; Ira Pastan
Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(11):5353-7.
1978: P Thomopoulos; M C Willingham; Ira Pastan
Studies on the regulation of insulin receptors in cultured BALB/3T3 fibroblasts.
Experimental cell research 1978;116(2):478-81.
1978: W B Anderson; C J Jaworski; M Gallo; Ira Pastan; J Pouysségur
Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis.
Nature 1978;275(5677):223-4.
1978: M C Willingham; S S Yamada; Ira Pastan
Ultrastructural antibody localization of alpha2-macroglobulin in membrane-limited vesicles in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(9):4359-63.
1978: B H Howard; S L Adams; M E Sobel; Ira Pastan; B de Crombrugghe
Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts.
The Journal of biological chemistry 1978;253(16):5869-74.
1978: S S Alexander; Giovanni Colonna; K M Yamada; Ira Pastan; H Edelhoch
Molecular properties of a major cell surface protein from chick embryo fibroblasts.
The Journal of biological chemistry 1978;253(16):5820-4.
1978: Ira Pastan; M Willingham
Cellular transformation and the 'morphologic phenotype' of transformed cells.
Nature 1978;274(5672):645-50.
1978: F R Maxfield; J Schlessinger; Y Shechter; Ira Pastan; M C Willingham
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization.
Cell 1978;14(4):805-10.
1978: David Wallach; P J Davies; Ira Pastan
Cyclic AMP-dependent phosphorylation of filamin in mammalian smooth muscle.
The Journal of biological chemistry 1978;253(13):4739-45.
1978: K M Yamada; K Olden; Ira Pastan
Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion.
Annals of the New York Academy of Sciences 1978;312():256-77.
1978: P J Davies; David Wallach; M C Willingham; Ira Pastan; M Yamaguchi; R M Robson
Filamin-actin interaction. Dissociation of binding from gelation by Ca2+-activated proteolysis.
The Journal of biological chemistry 1978;253(11):4036-42.
1978: E J Neufeld; Ira Pastan
A mutant fibroblast cell line defective in glycoprotein synthesis due to a deficiency of glucosamine phosphate acetyltransferase.
Archives of biochemistry and biophysics 1978;188(2):323-7.
1978: I Klein; M Willingham; Ira Pastan
A high molecular weight phosphoprotein in cultured fibroblasts that associates with polymerized tubulin.
Experimental cell research 1978;114(1):229-38.
1978: J Schlessinger; Y Shechter; M C Willingham; Ira Pastan
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(6):2659-63.
1978: David Wallach; P J Davies; Ira Pastan
Purification of mammalian filamin. Similarity to high molecular weight actin-binding protein in macrophages, platelets, fibroblasts, and other tissues.
The Journal of biological chemistry 1978;253(9):3228-35.
1978: L Moore; Ira Pastan
Energy-dependent calcium uptake by fibroblast microsomes.
Annals of the New York Academy of Sciences 1978;307():177-94.
1978: R M Pratt; Ira Pastan
Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis.
Nature 1978;272(5648):68-70.
1978: G Jay; R P Shiu; F T Jay; A S Levine; Ira Pastan
Identification of a transformation-specific protein induced by a Rous sarcoma virus.
Cell 1978;13(3):527-34.
1978: M C Willingham; Ira Pastan
The visualization of fluorescent proteins in living cells by video intensification microscopy (VIM).
Cell 1978;13(3):501-7.
1978: David Wallach; W Anderson; Ira Pastan
Activation of adenylate cyclase in cultured fibroblasts by trypsin.
The Journal of biological chemistry 1978;253(1):24-6.
1978: I Klein; L Moore; Ira Pastan
Effect of liposomes containing cholesterol on adenylate cyclase activity of cultured mammalian fibroblasts.
Biochimica et biophysica acta 1978;506(1):42-53.
1978: David Wallach; P Davies; P Bechtel; M Willingham; Ira Pastan
Cyclic AMP-dependent phosphorylation of the actin-binding protein filamin.
Advances in cyclic nucleotide research 1978;9():371-9.
1977: K M Yamada; D H Schlesinger; D W Kennedy; Ira Pastan
Characterization of a major fibroblast cell surface glycoprotein.
Biochemistry 1977;16(25):5552-9.
1977: Ira Pastan; M Willingham; W Anderson; M Gallo
Localization of serum-derived alpha 2 macroglobulin in cultured cells and decrease after Moloney sarcoma virus transformation.
Cell 1977;12(3):609-17.
1977: L Moore; Ira Pastan
Energy-dependent calcium uptake activity in cultured mouse fibroblast microsomes. Regulation of the uptake system by cell density.
The Journal of biological chemistry 1977;252(18):6304-9.
1977: R P Shiu; J Pouyssegur; Ira Pastan
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(9):3840-4.
1977: K M Yamada; S S Yamada; Ira Pastan
Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines.
The Journal of cell biology 1977;74(2):649-54.
1977: S L Adams; M E Sobel; B H Howard; K Olden; K M Yamada; B de Crombrugghe; Ira Pastan
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(8):3399-403.
1977: J Pouysségur; R P Shiu; Ira Pastan
Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation.
Cell 1977;11(4):941-7.
1977: J Schlessinger; L S Barak; G G Hammes; K M Yamada; Ira Pastan; W W Webb; E L Elson
Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(7):2909-13.
1977: P Davies; P Bechtel; Ira Pastan
Filamin inhibits actin activation of heavy meromyosin ATPase.
FEBS letters 1977;77(2):228-32.
1977: L Moore; Ira Pastan
Regulation of intracellular calcium in chick embryo fibroblast: calcium uptake by the microsomal fraction.
Journal of cellular physiology 1977;91(2):289-96.
1977: P Thomopoulos; F C Kosmakos; Ira Pastan; E Lovelace
Cyclic AMP increases the concentration of insulin receptors in cultured fibroblasts and lymphocytes.
Biochemical and biophysical research communications 1977;75(2):246-52.
1977: J Pouysségur; Ira Pastan
Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate.
The Journal of biological chemistry 1977;252(5):1639-46.
1977: M C Willingham; K M Yamada; S S Yamada; J Pouysségur; Ira Pastan
Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts.
Cell 1977;10(3):375-80.
1977: P Davies; Y Shizuta; K Olden; M Gallo; Ira Pastan
Phosphorylation of filamin and other proteins in cultured fibroblasts.
Biochemical and biophysical research communications 1977;74(1):300-7.
1977: J Pouysségur; M Willingham; Ira Pastan
Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(1):243-7.
1976: K M Yamada; Ira Pastan
The relationship between cell surface protein and glucose and alpha-aminoisobutyrate transport in transformed chick and mouse cells.
Journal of cellular physiology 1976;89(4):827-9.
1976: R E Ostlund; Ira Pastan
The purification and quantitation of myosin from cultured cells.
Biochimica et biophysica acta 1976;453(1):37-47.
1976: Y Shizuta; H Shizuta; M Gallo; P Davies; Ira Pastan
Purification and properties of filamin, and actin binding protein from chicken gizzard.
The Journal of biological chemistry 1976;251(21):6562-7.
1976: David Wallach; Ira Pastan
Stimulation of membranous guanylate cyclase by concentrations of calcium that are in the physiological range.
Biochemical and biophysical research communications 1976;72(3):859-65.
1976: K M Yamada; S H Ohanian; Ira Pastan
Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells.
Cell 1976;9(2):241-5.
1976: David Wallach; Ira Pastan
Stimulation of guanylate cyclase of fibroblasts by free fatty acids.
The Journal of biological chemistry 1976;251(18):5802-9.
1976: Ira Pastan; S Adhya
Cyclic adenosine 5'-monophosphate in Escherichia coli.
Bacteriological reviews 1976;40(3):527-51.
1976: P Thomopoulos; J Roth; E Lovelace; Ira Pastan
Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation.
Cell 1976;8(3):417-23.
1976: K Olden; M Willingham; Ira Pastan
Cell surface myosin in cultured fibroblasts.
Cell 1976;8(3):383-90.
1976: Y Shizuta; P J Davies; K Olden; Ira Pastan
Diminished content of plasma membrane-associated myosin in transformed fibroblasts.
Nature 1976;261(5559):414-5.
1976: J A Nesbitt; W B Anderson; Z Miller; Ira Pastan; T R Russell; D Gospodarowicz
Guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities and cyclic guanosine 3':5'-monophosphate levels in normal and transformed fibroblasts in culture.
The Journal of biological chemistry 1976;251(8):2344-52.
1976: K M Yamada; S S Yamada; Ira Pastan
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(4):1217-21.
1976: J M Pouysségur; Ira Pastan
Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):544-8.
1975: Z Miller; E Lovelace; M Gallo; Ira Pastan
Cyclic guanosine monophosphate and cellular growth.
Science (New York, N.Y.) 1975;190(4220):1213-5.
1975: S Nakanishi; S Adhya; Michael M Gottesman; Ira Pastan
Selective effects of MgCl2 and temperature on the initiation of transcription at lac, gal, and lambda promoters.
The Journal of biological chemistry 1975;250(20):8202-8.
1975: M C Willingham; Ira Pastan
Cyclic amp and cell morphology in cultured fibroblasts. Effects on cell shape, microfilament and microtubule distribution, and orientation to substratum.
The Journal of cell biology 1975;67(1):146-59.
1975: K M Yamada; S S Yamada; Ira Pastan
The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(8):3158-62.
1975: Ira Pastan
The role of cyclic AMP in malignant transformation.
American journal of clinical pathology 1975;63(5):669-70.
1975: M C Willingham; Ira Pastan
Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(4):1263-7.
1975: M Aboud; Ira Pastan
Activation of transcription by guanosine 5'-diphosphate,3'-diphosphate, transfer ribonucleic acid, and novel protein from Escherichia coli.
The Journal of biological chemistry 1975;250(6):2189-95.
1975: Ira Pastan
Regulation of cellular growth.
Advances in metabolic disorders 1975;8():7-16.
1975: Ira Pastan
Cyclic AMP and the malignant transformation of cells.
Advances in metabolic disorders 1975;8():377-83.
1975: Ira Pastan; G S Johnson; W B Anderson
Role of cyclic nucleotides in growth control.
Annual review of biochemistry 1975;44():491-522.
1975: W B Anderson; Ira Pastan
Altered adenylate cyclase activity: its role in growth regulation and malignant transformation of fibroblasts.
Advances in cyclic nucleotide research 1975;5():681-98.
1974: T R Russell; Ira Pastan
Cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities are under separate genetic control.
The Journal of biological chemistry 1974;249(24):7764-9.
1974: R E Musso; B de Crombrugghe; Ira Pastan; J Sklar; P Yot; S Weissman
The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(12):4940-4.
1974: W B Anderson; M Gallo; Ira Pastan
Adenylate cyclase activity in fibroblasts transformed by Kirsten or Moloney sarcoma viruses. Decreased activity and loss of response to prostaglandin E1.
The Journal of biological chemistry 1974;249(22):7041-8.
1974: M C Willingham; R E Ostlund; Ira Pastan
Myosin is a component of the cell surface of cultured cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(10):4144-8.
1974: M C Willingham; Ira Pastan
Cyclic AMP mediates the concanavalin A agglutinability of mouse fibroblasts.
The Journal of cell biology 1974;63(1):288-94.
1974: S Nakanishi; S Adhya; Michael M Gottesman; Ira Pastan
Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo.
Cell 1974;3(1):39-46.