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Gregory Burrows

Research Profile

Chemicals & Drugs

Disorders

Autoimmune Experimental Encephalomyelitis

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Concepts & Ideas

Molecular Sequence Data

Physiology

Lymphocyte Activation

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Publications

TOP 3
Gil Benedek; Dennis Bourdette; Richard Bucala; Gregory G Burrows; Lin Leng; Roberto Meza-Romero; Halina Offner; Shayne Andrew; Arthur A Vandenbark
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects.
Arthur A Vandenbark; Shayne Andrew; Gil Benedek; Abigail C Buenafe; Yuan K Chou; Rony Dahan; Jianya Huan; Roberto Meza-Romero; Jeffery L Mooney; Halina Offner; Yoram Reiter; Gregory G Burrows
A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.
Gregory G Burrows; Jianya Huan; Roberto Meza-Romero; Jeffrey L Mooney; Sushmita Sinha; Arthur A Vandenbark; Halina Offner
Gilt required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis.

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All Publications

2013: Gil Benedek; Dennis Bourdette; Richard Bucala; Gregory G Burrows; Lin Leng; Roberto Meza-Romero; Halina Offner; Shayne Andrew; Arthur A Vandenbark
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects.
European journal of immunology 2013;43(5):1309-21.
2013: Arthur A Vandenbark; Shayne Andrew; Gil Benedek; Abigail C Buenafe; Yuan K Chou; Rony Dahan; Jianya Huan; Roberto Meza-Romero; Jeffery L Mooney; Halina Offner; Yoram Reiter; Gregory G Burrows
A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance.
Journal of autoimmunity 2013;40():96-110.
2012: Gregory G Burrows; Jianya Huan; Roberto Meza-Romero; Jeffrey L Mooney; Sushmita Sinha; Arthur A Vandenbark; Halina Offner
Gilt required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis.
Metabolic brain disease 2012;27(2):143-9.
2012: Vijayshree Yadav; Christopher Bever Jr; Dennis N Bourdette; James D Bowen; Gregory G Burrows; Al J Ferro; Andrew Goldstein; Sharon G Lynch; David Mattson; Halina Offner; Jana Preiningerova; Jack Simon; Arthur A Vandenbark
Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study.
Autoimmune diseases 2012;2012():954739.
2012: Grazyna Adamus; Shayne Andrew; Lori Brown; Gregory G Burrows; Roberto Meza-Romero; Arthur A Vandenbark
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice.
Investigative ophthalmology & visual science 2012;53(1):406-12.
2011: Suzan Dziennis; Paco S Herson; Patricia D Hurn; Sarah Mader; Kozaburo Akiyoshi; Patricia Ayala; Gregory G Burrows; Xuefang Ren; Arthur Vandenbark; Halina A Offner
Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice.
Metabolic brain disease 2011;26(2):123-33.
2011: Rony Dahan; Moran Tabul; Yuan K Chou; Roberto Meza-Romero; Shayne Andrew; Adolph J Ferro; Gregory G Burrows; Halina Offner; Arthur A Vandenbark; Yoram Reiter
TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes.
European journal of immunology 2011;41(5):1465-79.
2011: Halina Offner; Sushmita Sinha; Gregory G Burrows; Adolph J Ferro; Arthur A Vandenbark
RTL therapy for multiple sclerosis: a Phase I clinical study.
Journal of neuroimmunology 2011;231(1-2):7-14.
2011: Sushmita Sinha; Sandhya Subramanian; Arthur A Vandenbark; Gregory G Burrows; Lisa M Miller; Halina Offner
RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS.
PloS one 2011;6(7):e21868.
2011: Jianya Huan; Roberto Meza-Romero; Jeff Mooney; Arthur Vandenbark; Halina Offner; Gregory G Burrows
Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease.
Mucosal immunology 2011;4(1):112-20.
2010: Sushmita Sinha; Lisa Miller; Sandhya Subramanian; Owen J T McCarty; Thomas Proctor; Roberto Meza-Romero; Jianya Huan; Gregory G Burrows; Arthur Vandenbark; Halina Offner
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2010;225(1-2):52-61.
2010: Sushmita Sinha; Sandhya Subramanian; Ashley Emerson-Webber; Maren Lindner; Gregory G Burrows; Marjorie R Grafe; Christopher Linington; Arthur Vandenbark; Claude C A Bernard; Halina Offner
Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2010;5(2):231-9.
2010: Asako Itakura; Joseph E Aslan; Sushmita Sinha; Tara White; Ishan A Patel; Roberto Meza-Romero; Arthur Vandenbark; Gregory G Burrows; Halina Offner; Owen J T McCarty
Characterization of human platelet binding of recombinant T cell receptor ligand.
Journal of neuroinflammation 2010;7():75.
2010: Grazyna Adamus; Landon J Karren; Jeff Mooney; Gregory G Burrows
A promising therapeutic approach for treatment of posterior uveitis: recombinant T cell receptor ligand protects Lewis rats from acute and recurrent experimental autoimmune uveitis.
Ophthalmic research 2010;44(1):24-33.
2009: Sandhya Subramanian; Bing Zhang; Yasuharu Kosaka; Gregory G Burrows; Marjorie R Grafe; Arthur Vandenbark; Patricia D Hurn; Halina Offner
Recombinant T cell receptor ligand treats experimental stroke.
Stroke; a journal of cerebral circulation 2009;40(7):2539-45.
2009: Sushmita Sinha; Sandhya Subramanian; Lisa Miller; Thomas M Proctor; Chris Roberts; Gregory G Burrows; Arthur Vandenbark; Halina Offner
Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(12):3816-23.
2008: Jianya Huan; Laurie J Kaler; Jeff Mooney; Sandhya Subramanian; Corwyn Hopke; Arthur Vandenbark; Edward F Rosloniec; Gregory G Burrows; Halina Offner
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1249-57.
2008: Halina Offner; Sushmita Sinha; Chunhe Wang; Gregory G Burrows; Arthur Vandenbark
Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis.
Reviews in the neurosciences 2008;19(4-5):327-39.
2007: Sushmita Sinha; Sandhya Subramanian; Thomas M Proctor; Laurie J Kaler; Marjorie R Grafe; Rony Dahan; Jianya Huan; Arthur Vandenbark; Gregory G Burrows; Halina Offner
A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(46):12531-9.
2007: Jason Link; Cathleen Rich; Maya Korat; Gregory G Burrows; Halina Offner; Arthur Vandenbark
Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice.
Clinical immunology (Orlando, Fla.) 2007;123(1):95-104.
2006: Andrew P Fontenot; Timothy S Keizer; Mark McCleskey; Doug Mack; Roberto Meza-Romero; Jianya Huan; David M Edwards; Yuan K Chou; Arthur Vandenbark; Brian Scott; Gregory G Burrows
Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3874-83.
2006: Chunhe Wang; Bruce G Gold; Laurie J Kaler; Xiaolin Yu; Michael Afentoulis; Gregory G Burrows; Arthur Vandenbark; Dennis N Bourdette; Halina Offner
Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE.
Journal of neurochemistry 2006;98(6):1817-27.
2006: Grazyna Adamus; Gregory G Burrows; Arthur Vandenbark; Halina Offner
Treatment of autoimmune anterior uveitis with recombinant TCR ligands.
Investigative ophthalmology & visual science 2006;47(6):2555-61.
2006: Andrew P Fontenot; David M Edwards; Yuan K Chou; Doug Mack; Dorian LaTocha; Arthur Vandenbark; Gregory G Burrows
Self-presentation of beryllium by BAL CD4+ T cells: T cell-T cell interactions and their potential role in chronic beryllium disease.
European journal of immunology 2006;36(4):930-9.
2005: Halina Offner; Sandhya Subramanian; Chunhe Wang; Michael Afentoulis; Arthur Vandenbark; Jianya Huan; Gregory G Burrows
Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):4103-11.
2005: Jianya Huan; Nicole Culbertson; Leslie Spencer; Richard Bartholomew; Gregory G Burrows; Yuan K Chou; Dennis N Bourdette; Steven F Ziegler; Halina Offner; Arthur Vandenbark
Decreased FOXP3 levels in multiple sclerosis patients.
Journal of neuroscience research 2005;81(1):45-52.
2005: Gregory G Burrows
Systemic immunomodulation of autoimmune disease using MHC-derived recombinant TCR ligands.
Current drug targets. Inflammation and allergy 2005;4(2):185-93.
2005: Yuan K Chou; David M Edwards; Andrew D Weinberg; Arthur Vandenbark; Brian L Kotzin; Andrew P Fontenot; Gregory G Burrows
Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4316-24.
2004: Yuan K Chou; Nicole Culbertson; Cathleen Rich; Dorian LaTocha; Abigail C Buenafe; Jianya Huan; Jason Link; J M Wands; Willi K Born; Halina Offner; Dennis N Bourdette; Gregory G Burrows; Arthur Vandenbark
T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice.
Journal of neuroscience research 2004;77(5):670-80.
2004: Cathleen Rich; Jason Link; Alex Zamora; Helle Jacobsen; Roberto Meza-Romero; Halina Offner; Richard Jones; Gregory G Burrows; Lars Fugger; Arthur Vandenbark
Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.
European journal of immunology 2004;34(5):1251-61.
2004: Abigail C Buenafe; Laura Tsaknaridis; Leslie Spencer; Kevin S Hicks; Rachel H McMahan; Lisa Watson; Nicole Culbertson; Dorian LaTocha; Keith Wegmann; Tom Finn; Richard Bartholomew; Gregory G Burrows; Ruth H Whitham; Dennis N Bourdette; Richard Jones; Halina Offner; Yuan K Chou; Arthur Vandenbark
Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants.
Journal of neuroscience research 2004;76(1):129-40.
2004: Jianya Huan; Sandhya Subramanian; Richard Jones; Cathleen Rich; Jason Link; Jeff Mooney; Dennis N Bourdette; Arthur Vandenbark; Gregory G Burrows; Halina Offner
Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4556-66.
2004: Yuan K Chou; Gregory G Burrows; Dorian LaTocha; Chunhe Wang; Sandhya Subramanian; Dennis N Bourdette; Arthur Vandenbark
CD4 T-cell epitopes of human alpha B-crystallin.
Journal of neuroscience research 2004;75(4):516-23.
2003: Chunhe Wang; Jeff Mooney; Roberto Meza-Romero; Yuan K Chou; Jianya Huan; Arthur Vandenbark; Halina Offner; Gregory G Burrows
Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1934-40.
2003: Rachel H McMahan; Lisa Watson; Roberto Meza-Romero; Gregory G Burrows; Dennis N Bourdette; Abigail C Buenafe
Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide.
The Journal of biological chemistry 2003;278(33):30961-70.
2003: Arthur Vandenbark; Cathleen Rich; Jeff Mooney; Alex Zamora; Chunhe Wang; Jianya Huan; Lars Fugger; Halina Offner; Richard Jones; Gregory G Burrows
Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):127-33.
2001: Gregory G Burrows; Yuan K Chou; Chunhe Wang; J W Chang; Tom Finn; Nicole Culbertson; J Kim; Dennis N Bourdette; Deborah A Lewinsohn; David M Lewinsohn; M Ikeda; T Yoshioka; Charles N Allen; Halina Offner; Arthur Vandenbark
Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4386-95.
2001: J W Chang; DE Mechling; Hans Peter Bächinger; Gregory G Burrows
Design, engineering, and production of human recombinant t cell receptor ligands derived from human leukocyte antigen DR2.
The Journal of biological chemistry 2001;276(26):24170-6.
2000: Gregory G Burrows; KL Adlard; Bruce F Bebo; J W Chang; K Tenditnyy; Arthur Vandenbark; Halina Offner
Regulation of encephalitogenic T cells with recombinant TCR ligands.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6366-71.
2000: Agata Matejuk; Arthur Vandenbark; Gregory G Burrows; Bruce F Bebo; Halina Offner
Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3924-31.
2000: Arthur Vandenbark; Nicole Culbertson; Tom Finn; D Barnes; Abigail C Buenafe; Gregory G Burrows; S Law; Yuan K Chou; Halina Offner
Human TCR as antigen: homologies and potentially cross-reactive HLA-DR2-restricted epitopes within the AV and BV CDR2 loops.
Critical reviews in immunology 2000;20(1):57-83.
1999: Gregory G Burrows; J W Chang; Hans Peter Bächinger; Dennis N Bourdette; Halina Offner; Arthur Vandenbark
Design, engineering and production of functional single-chain T cell receptor ligands.
Protein engineering 1999;12(9):771-8.
1998: Gregory G Burrows; Bruce F Bebo; KL Adlard; Arthur Vandenbark; Halina Offner
Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5987-96.
1998: Halina Offner; KL Adlard; Bruce F Bebo; JC Schuster; Gregory G Burrows; Abigail C Buenafe; Arthur Vandenbark
Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2178-86.
1998: K S Ariail; Bruce F Bebo; KL Adlard; I Robey; Gregory G Burrows; MJ Newman; Charles W Todd; Arthur Vandenbark; Halina Offner
Novel adjuvants for induction of T-cell and antibody responses to encephalitogenic and regulatory determinants in Lewis rats.
Vaccine 1998;16(1):99-108.
1997: Gregory G Burrows; K Ariail; B Celnik; J E Gambee; Halina Offner; Arthur Vandenbark
Multiple class I motifs revealed by sequencing naturally processed peptides eluted from rat T cell MHC molecules.
Journal of neuroscience research 1997;49(1):107-16.
1996: Gregory G Burrows; K Ariail; B Celnik; J E Gambee; Bruce F Bebo; Halina Offner; Arthur Vandenbark
Variation in H-2K(k) peptide motif revealed by sequencing naturally processed peptides from T-cell hybridoma class I molecules.
Journal of neuroscience research 1996;45(6):803-11.
1996: M Vainiene; Gregory G Burrows; K Ariail; I Robey; Arthur Vandenbark; Halina Offner
Neonatal injection of Lewis rats with recombinant V beta 8.2 induces T cell but not B cell tolerance and increased severity of experimental autoimmune encephalomyelitis.
Journal of neuroscience research 1996;45(4):475-86.
1994: G F Lee; Gregory G Burrows; M R Lebert; D P Dutton; Gerald L Hazelbauer
Deducing the organization of a transmembrane domain by disulfide cross-linking. The bacterial chemoreceptor Trg.
The Journal of biological chemistry 1994;269(47):29920-7.
1993: Fabian F Moebius; Gregory G Burrows; Markus Hanner; E Schmid; Jörg Striessnig; Hartmut Glossmann
Identification of a 27-kDa high affinity phenylalkylamine-binding polypeptide as the sigma 1 binding site by photoaffinity labeling and ligand-directed antibodies.
Molecular pharmacology 1993;44(5):966-71.
1993: Fabian F Moebius; Gregory G Burrows; Jörg Striessnig; Hartmut Glossmann
Biochemical characterization of a 22-kDa high affinity antiischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for antiischemic drug action.
Molecular pharmacology 1993;43(2):139-48.
1989: Gregory G Burrows; M E Newcomer; Gerald L Hazelbauer
Purification of receptor protein Trg by exploiting a property common to chemotactic transducers of Escherichia coli.
The Journal of biological chemistry 1989;264(29):17309-15.