FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Douglas Losordo

Research Profile

Physiology

Chemicals & Drugs

Living Beings

Procedures

Genetic Therapy

Anatomy

Disorders

Devices

Gene Transfer Techniques

Co-author Network

Publications

TOP 3
Kentaro Jujo; Christine Kamide; Ekaterina Klyachko; Michio Asahi; Trevor Clarke; Nobuhisa Hagiwara; Masaaki Ii; Aiko Ito; Sol Misener; Gangjian Qin; Marie-Ange Renault; JEROME RONCALLI; Haruki Sekiguchi; Toshikazu Tanaka; Tina Thorne; Jörn Tongers; Yukio Tsurumi; Douglas Losordo
CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.
Haruki Sekiguchi; Yasuhiko Tabata; Tina Thorne; Michio Asahi; Nobuhisa Hagiwara; Hiromichi Hamada; Masaaki Ii; Aiko Ito; Kentaro Jujo; Masatoshi Kawana; John A Kessler; Ekaterina Klyachko; Douglas Losordo
Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve.
Haruki Sekiguchi; Yasuhiko Tabata; Toshikazu Tanaka; Tina Thorne; Trevor Clarke; Nobuhisa Hagiwara; Masaaki Ii; Aiko Ito; Kentaro Jujo; Ekaterina Klyachko; Marie-Ange Renault; Douglas Losordo
Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Douglas Losordo (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Kentaro Jujo; Christine Kamide; Ekaterina Klyachko; Michio Asahi; Trevor Clarke; Nobuhisa Hagiwara; Masaaki Ii; Aiko Ito; Sol Misener; Gangjian Qin; Marie-Ange Renault; JEROME RONCALLI; Haruki Sekiguchi; Toshikazu Tanaka; Tina Thorne; Jörn Tongers; Yukio Tsurumi; Douglas Losordo
CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.
Circulation 2013;127(1):63-73.
2013: Haruki Sekiguchi; Yasuhiko Tabata; Tina Thorne; Michio Asahi; Nobuhisa Hagiwara; Hiromichi Hamada; Masaaki Ii; Aiko Ito; Kentaro Jujo; Masatoshi Kawana; John A Kessler; Ekaterina Klyachko; Douglas Losordo
Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve.
Angiogenesis 2013;16(1):45-58.
2012: Haruki Sekiguchi; Yasuhiko Tabata; Toshikazu Tanaka; Tina Thorne; Trevor Clarke; Nobuhisa Hagiwara; Masaaki Ii; Aiko Ito; Kentaro Jujo; Ekaterina Klyachko; Marie-Ange Renault; Douglas Losordo
Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein.
Laboratory investigation; a journal of technical methods and pathology 2012;92(4):532-42.
2012: Yukihide Nishimura; Gangjian Qin; Marie-Ange Renault; Haruki Sekiguchi; Hideya Takenaka; Tina Thorne; Meredith Millay; Sol Misener; Jun Asai; Hiromichi Hamada; Masaaki Ii; Aiko Ito; Kentaro Jujo; Christine Kamide; Norito Katoh; John Kenny; Saburo Kishimoto; Douglas Losordo
CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice.
The Journal of investigative dermatology 2012;132(3 Pt 1):711-20.
2012: Gian Paolo Fadini; Douglas Losordo; Stefanie Dimmeler
Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use.
Circulation research 2012;110(4):624-37.
2012: Seungwoon Seo; Hardeep P Singh; anees fatima; Pedro M Lacal; Ordan J Lehmann; Ting Liu; Douglas Losordo; Amy Sasman; Kathryn M Schultz; Tsutomu Kume
Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):2015-20.
2011: Prasanna Krishnamurthy; Erin Lambers; Douglas Losordo; Gangjian Qin; Veronica Ramirez; Melissa Thal; Suresh Verma; Eneda Hoxha; Raj Kishore
Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium.
Circulation research 2011;109(11):1280-9.
2011: Stefanie Dimmeler; Douglas Losordo
Stem cells review series: an introduction.
Circulation research 2011;109(8):907-9.
2011: Matthew J Webber; Jörn Tongers; Johann Bauersachs; Douglas Losordo; Katja-Theres Marquardt; Christina J Newcomb; Samuel I Stupp
Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13438-43.
2011: JEROME RONCALLI; Toshikazu Tanaka; Tina Thorne; Jörn Tongers; Masaaki Ii; Kentaro Jujo; Christine Kamide; Ekaterina Klyachko; Sol Misener; M Renault; Douglas Losordo
Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization.
Journal of the American College of Cardiology 2011;57(24):2444-52.
2011: Mariangela Palladino; Ilaria Gatto; Valentina Neri; Stefania Straino; Marcy Silver; Alessandra Tritarelli; Andrea Piccioni; Roy Smith; Eleonora Gaetani; Douglas Losordo; Filippo Crea; Maurizio Capogrossi; Roberto Pola
Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):658-66.
2011: Raj Kishore; Tengiz Tkebuchava; Sharath P Sasi; Marcy Silver; Hu-Ya Gilbert; Young-Sup Yoon; Hee-Young Park; Tina Thorne; Douglas Losordo; David Goukassian
Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium.
Advances in experimental medicine and biology 2011;691():433-48.
2010: Min Cheng; Junlan Zhou; Min Wu; Chan Boriboun; Tina Thorne; Ting Liu; Zhifu Xiang; Qiutang Zeng; Toshikazu Tanaka; Yao Liang Tang; Raj Kishore; Michael H Tomasson; Richard J Miller; Douglas Losordo; Gangjian Qin
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity.
Circulation research 2010;107(9):1083-93.
2010: Nirat Beohar; Jonathan Rapp; Sanjay Pandya; Douglas Losordo
Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease.
Journal of the American College of Cardiology 2010;56(16):1287-97.
2010: Marie-Ange Renault; JEROME RONCALLI; Jörn Tongers; Tina Thorne; Ekaterina Klyachko; Sol Misener; Olga V Volpert; Shanu Mehta; Aaron Burg; Corinne Luedemann; Gangjian Qin; Raj Kishore; Douglas Losordo
Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.
Journal of molecular and cellular cardiology 2010;49(3):490-8.
2010: JEROME RONCALLI; Jörn Tongers; Douglas Losordo
Update on gene therapy for myocardial ischaemia and left ventricular systolic dysfunction or heart failure.
Archives of cardiovascular diseases 2010;103(8-9):469-76.
2010: Arin B Aurora; Aryn B Aurora; Dauren Biyashev; Yelena Mirochnik; Tetiana A Zaichuk; Cristina Sánchez-Martinez; Marie-Ange Renault; Douglas Losordo; Olga V Volpert
NF-kappaB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement.
Blood 2010;116(3):475-84.
2010: Prasanna Krishnamurthy; Erin Lambers; Suresh Verma; Tina Thorne; Gangjian Qin; Douglas Losordo; Raj Kishore
Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2484-94.
2010: Kentaro Jujo; Hiromichi Hamada; Atsushi Iwakura; Tina Thorne; Haruki Sekiguchi; Trevor Clarke; Aiko Ito; Sol Misener; Toshikazu Tanaka; Ekaterina Klyachko; Koichi Kobayashi; Jörn Tongers; JEROME RONCALLI; Yukio Tsurumi; Nobuhisa Hagiwara; Douglas Losordo
CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):11008-13.
2010: Jörn Tongers; JEROME RONCALLI; Douglas Losordo
Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation.
Microvascular research 2010;79(3):200-6.
2010: Matthew J Webber; Jörn Tongers; Marie-Ange Renault; JEROME RONCALLI; Douglas Losordo; Samuel I Stupp
Development of bioactive peptide amphiphiles for therapeutic cell delivery.
Acta biomaterialia 2010;6(1):3-11.
2009: Rajesh Gupta; Jörn Tongers; Douglas Losordo
Human studies of angiogenic gene therapy.
Circulation research 2009;105(8):724-36.
2009: Marie-Ange Renault; JEROME RONCALLI; Jörn Tongers; Sol Misener; Tina Thorne; Kentaro Jujo; Aiko Ito; Trevor Clarke; Chris Fung; Meredith Millay; Christine Kamide; Andrew Scarpelli; Ekaterina Klyachko; Douglas Losordo
The Hedgehog transcription factor Gli3 modulates angiogenesis.
Circulation research 2009;105(8):818-26.
2009: Junlan Zhou; Yan Zhu; Min Cheng; Deepika Dinesh; Tina Thorne; Kian-Keong Poh; Dongxu Liu; Chantal Botros; Yao Liang Tang; Nichole Reisdorph; Raj Kishore; Douglas Losordo; Gangjian Qin
Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.
Circulation 2009;120(13):1213-21.
2009: Masaaki Ii; Masaaki Hoshiga; Nobuyuki Negoro; Ryosuke Fukui; Takahiro Nakakoji; Eiko Kohbayashi; N Shibata; Daisuke Furutama; Tadashi Ishihara; Toshiaki Hanafusa; Douglas Losordo; Nakaaki Ohsawa
Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury.
Atherosclerosis 2009;206(1):77-85.
2009: Yao Liang Tang; Wuqiang Zhu; Min Cheng; Lijuan Chen; John Zhang; Tao Sun; Raj Kishore; M Ian Phillips; Douglas Losordo; Gangjian Qin
Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression.
Circulation research 2009;104(10):1209-16.
2009: Haruki Sekiguchi; Masaaki Ii; Douglas Losordo
The relative potency and safety of endothelial progenitor cells and unselected mononuclear cells for recovery from myocardial infarction and ischemia.
Journal of cellular physiology 2009;219(2):235-42.
2009: Allan H Ropper; Kenneth C Gorson; Clifton L Gooch; David H Weinberg; Ann Pieczek; James H Ware; Joshua Kershen; Adam Rogers; Drasko Simovic; Peter Schratzberger; Rudolf Kirchmair; Douglas Losordo
Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial.
Annals of neurology 2009;65(4):386-93.
2009: Willem-Peter T Ruifrok; Rudolf A de Boer; Atsushi Iwakura; Marcy Silver; Kengo Kusano; Rene A Tio; Douglas Losordo
Estradiol-induced, endothelial progenitor cell-mediated neovascularization in male mice with hind-limb ischemia.
Vascular medicine (London, England) 2009;14(1):29-36.
2009: Prasanna Krishnamurthy; Rajasingh Johnson; Erin Lambers; Gangjian Qin; Douglas Losordo; Raj Kishore
IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR.
Circulation research 2009;104(2):e9-18.
2009: Douglas Losordo; Raj Kishore
A big promise from the very small identification of circulating embryonic stem-like pluripotent cells in patients with acute myocardial infarction.
Journal of the American College of Cardiology 2009;53(1):10-2.
2009: Jörn Tongers; Matthew J Webber; Douglas Losordo
Bioengineering to enhance progenitor cell therapeutics.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 2009;36(2):140-4.
2008: Kentaro Jujo; Masaaki Ii; Douglas Losordo
Endothelial progenitor cells in neovascularization of infarcted myocardium.
Journal of molecular and cellular cardiology 2008;45(4):530-44.
2008: JEROME RONCALLI; Didier Carrie; Jean-Marie Fauvel; Douglas Losordo
A "hawk's beak" to identify the new transient midventricular Tako-Tsubo syndrome.
International journal of cardiology 2008;127(3):e179-80.
2008: Jörn Tongers; JEROME RONCALLI; Douglas Losordo
Therapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age.
Circulation 2008;118(1):9-16.
2008: Rajasingh Johnson; Erin Lambers; Hiromichi Hamada; Evelyn Bord; Tina Thorne; Ilona Goukassian; Prasanna Krishnamurthy; Kenneth M Rosen; Deepali Ahluwalia; Yan Zhu; Gangjian Qin; Douglas Losordo; Raj Kishore
Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair.
Circulation research 2008;102(11):e107-17.
2008: JEROME RONCALLI; Jörn Tongers; Marie-Ange Renault; Douglas Losordo
Biological approaches to ischemic tissue repair: gene- and cell-based strategies.
Expert review of cardiovascular therapy 2008;6(5):653-68.
2008: JEROME RONCALLI; Jörn Tongers; Marie-Ange Renault; Douglas Losordo
Endothelial progenitor cells in regenerative medicine and cancer: a decade of research.
Trends in biotechnology 2008;26(5):276-83.
2008: Atsuhiko Kawamoto; Douglas Losordo
Endothelial progenitor cells for cardiovascular regeneration.
Trends in cardiovascular medicine 2008;18(1):33-7.
2007: Jörn Tongers; Douglas Losordo
Frontiers in nephrology: the evolving therapeutic applications of endothelial progenitor cells.
Journal of the American Society of Nephrology : JASN 2007;18(11):2843-52.
2007: Samar Farha; Kewal Asosingh; Daniel Laskowski; Lauren Licina; Haruki Sekiguchi; Haruki Sekigushi; Douglas Losordo; raed dweik; Herbert P Wiedemann; Serpil C Erzurum
Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(5):1789-95.
2007: Rajasingh Johnson; Evelyn Bord; Hiromichi Hamada; Erin Lambers; Gangjian Qin; Douglas Losordo; Raj Kishore
STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
Circulation research 2007;101(9):910-8.
2007: Marie-Ange Renault; Douglas Losordo
Therapeutic myocardial angiogenesis.
Microvascular research 2007;74(2-3):159-71.
2007: Margot Egger; Wilfried Schgoer; Arno G E Beer; Johannes Jeschke; Johannes Leierer; Markus Theurl; Silke Frauscher; Oren M Tepper; Andreas Niederwanger; Andreas Ritsch; Marianne Kearney; Julia Wanschitz; Geoffrey C Gurtner; Reiner Fischer-Colbrie; Günter Weiss; Hildegunde Piza-Katzer; Douglas Losordo; Josef R Patsch; Peter Schratzberger; Rudolf Kirchmair
Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2906-17.
2007: Rajasingh Johnson; Evelyn Bord; Gangjian Qin; Masaaki Ii; Marcy Silver; Hiromichi Hamada; Deepali Ahluwalia; David Goukassian; Yan Zhu; Douglas Losordo; Raj Kishore
Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice.
Endocrinology 2007;148(8):3618-24.
2007: Douglas Losordo; Richard A Schatz; Christopher J White; James E Udelson; Vimal Veereshwarayya; Michelle Durgin; Kian Keong Poh; Robert Weinstein; Marianne Kearney; Muqtada Chaudhry; Aaron Burg; Liz Eaton; Lindsay Heyd; Tina Thorne; Leon Shturman; Peter Hoffmeister; Ken Story; Victor Zak; Douglas Dowling; Jay H Traverse; Rachel E Olson; Janice Flanagan; Donata Sodano; Toshinori Murayama; Atsuhiko Kawamoto; Kengo Fukushima Kusano; Jill Wollins; Frederick Welt; Pinak Shah; Peter Soukas; Takayuki Asahara; Timothy D Henry
Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.
Circulation 2007;115(25):3165-72.
2007: Kazuichi Maruyama; Jun Asai; Masaaki Ii; Tina Thorne; Douglas Losordo; Patricia A D'Amore
Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.
The American journal of pathology 2007;170(4):1178-91.
2007: Marie-Ange Renault; Douglas Losordo
The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.
Circulation research 2007;100(6):749-50.
2007: Raj Kishore; Douglas Losordo
Gene therapy for restenosis: biological solution to a biological problem.
Journal of molecular and cellular cardiology 2007;42(3):461-8.
2007: David Goukassian; Gangjian Qin; Christine Dolan; Toshinori Murayama; Marcy Silver; Cynthia Curry; Elizabeth Eaton; Corinne Luedemann; Hong Ma; Takayuki Asahara; Victor Zak; Shanu Mehta; Aaron Burg; Tina Thorne; Raj Kishore; Douglas Losordo
Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization.
Circulation 2007;115(6):752-62.
2007: Kengo Kusano; Yoshiaki Tsutsumi; Jarrod Dean; Mary Gavin; Hong Ma; Marcy Silver; Tina Thorne; Yan Zhu; Douglas Losordo; Ryuichi Aikawa
Long-term stable expression of human growth hormone by rAAV promotes myocardial protection post-myocardial infarction.
Journal of molecular and cellular cardiology 2007;42(2):390-9.
2007: Kyosuke Takeshita; Minoru Satoh; Masaaki Ii; Marcy Silver; Florian P Limbourg; Yasushi Mukai; Yoshiyuki Rikitake; Freddy Radtke; Thomas Gridley; Douglas Losordo; James K Liao
Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
Circulation research 2007;100(1):70-8.
2007: A Quraishi; Douglas Losordo
Ischemic tissue repair by autologous bone marrow-derived stem cells: scientific basis and preclinical data.
Handbook of experimental pharmacology 2007;(180):167-79.
2007: Rudolf Kirchmair; Anne B Tietz; Eleftheria Panagiotou; Dirk H Walter; Marcy Silver; Young-sup Yoon; Peter Schratzberger; Alberto Weber; Kengo Kusano; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):69-75.
2007: Masaaki Ii; Douglas Losordo
Statins and the endothelium.
Vascular pharmacology 2007;46(1):1-9.
2006: Hiromichi Hamada; Myeong Kon Kim; Atsushi Iwakura; Masaaki Ii; Tina Thorne; Gangjian Qin; Jun Asai; Yoshiaki Tsutsumi; Haruki Sekiguchi; Marcy Silver; Andrea Wecker; Evelyn Bord; Yan Zhu; Raj Kishore; Douglas Losordo
Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.
Circulation 2006;114(21):2261-70.
2006: Atsuhiko Kawamoto; Hiroto Iwasaki; Kengo Kusano; Toshinori Murayama; Akira Oyamada; Marcy Silver; Christine Hulbert; Mary Gavin; Allison Hanley; Hong Ma; Marianne Kearney; Victor Zak; Takayuki Asahara; Douglas Losordo
CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells.
Circulation 2006;114(20):2163-9.
2006: Jiyoon Lee; Andrea Wecker; Douglas Losordo; Young-sup Yoon
Derivation and characterization of bone marrow-derived multipotent stem cells.
Experimental hematology 2006;34(11):1602-3.
2006: Rajasingh Johnson; Evelyn Bord; Corinne Luedemann; Jun Asai; Hiromichi Hamada; Tina Thorne; Gangjian Qin; David Goukassian; Yan Zhu; Douglas Losordo; Raj Kishore
IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2112-4.
2006: Brent D Wilson; Masaaki Ii; Kye Won Park; Arminda Suli; Lise K Sorensen; Fréderic Larrieu-Lahargue; Lisa D Urness; Wonhee Suh; Jun Asai; Gerhardus A H Kock; Tina Thorne; Marcy Silver; Kirk R Thomas; Chi-Bin Chien; Douglas Losordo; Dean Y Li
Netrins promote developmental and therapeutic angiogenesis.
Science (New York, N.Y.) 2006;313(5787):640-4.
2006: Gangjian Qin; Raj Kishore; Christine Dolan; Marcy Silver; Andrea Wecker; Corinne Luedemann; Tina Thorne; Allison Hanley; Cynthia Curry; Lindsay Heyd; Deepika Dinesh; Marianne Kearney; Fabio Martelli; Toshinori Murayama; David Goukassian; Yan Zhu; Douglas Losordo
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11015-20.
2006: Sudha Sinha; Kian-Keong Poh; Donata Sodano; Janice Flanagan; Cindy Ouilette; Marianne Kearney; Lindsay Heyd; Jill Wollins; Douglas Losordo; Robert Weinstein
Safety and efficacy of peripheral blood progenitor cell mobilization and collection in patients with advanced coronary heart disease.
Journal of clinical apheresis 2006;21(2):116-20.
2006: Jun Asai; Hideya Takenaka; Kengo Fukushima Kusano; Masaaki Ii; Corinne Luedemann; Cynthia Curry; Elizabeth Eaton; Atsushi Iwakura; Yoshiaki Tsutsumi; Hiromichi Hamada; Saburo Kishimoto; Tina Thorne; Raj Kishore; Douglas Losordo
Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling.
Circulation 2006;113(20):2413-24.
2006: Atsushi Iwakura; Shubha Shastry; Corinne Luedemann; Hiromichi Hamada; Atsuhiko Kawamoto; Raj Kishore; Yan Zhu; Gangjian Qin; Marcy Silver; Tina Thorne; Liz Eaton; Haruchika Masuda; Takayuki Asahara; Douglas Losordo
Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9.
Circulation 2006;113(12):1605-14.
2006: Masaaki Ii; Hideya Takenaka; Jun Asai; Kayoko Ibusuki; Yusuke Mizukami; Kazuichi Maruyama; Young-sup Yoon; Andrea Wecker; Corinne Luedemann; Elizabeth Eaton; Marcy Silver; Tina Thorne; Douglas Losordo
Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury.
Circulation research 2006;98(5):697-704.
2006: Frederick G P Welt; Douglas Losordo
Cell therapy for acute myocardial infarction: curb your enthusiasm?
Circulation 2006;113(10):1272-4.
2006: Satoshi Shintani; Kengo Kusano; Masaaki Ii; Atsushi Iwakura; Lindsay Heyd; Cynthia Curry; Andrea Wecker; Mary Gavin; Hong Ma; Marianne Kearney; Marcy Silver; Tina Thorne; Toyoaki Murohara; Douglas Losordo
Synergistic effect of combined intramyocardial CD34+ cells and VEGF2 gene therapy after MI.
Nature clinical practice. Cardiovascular medicine 2006;3 Suppl 1():S123-8.
2006: Gangjian Qin; Masaaki Ii; Marcy Silver; Andrea Wecker; Evelyn Bord; Hong Ma; Mary Gavin; David Goukassian; Young-sup Yoon; Thalia Papayannopoulou; Takayuki Asahara; Marianne Kearney; Tina Thorne; Cynthia Curry; Liz Eaton; Lindsay Heyd; Deepika Dinesh; Raj Kishore; Yan Zhu; Douglas Losordo
Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization.
The Journal of experimental medicine 2006;203(1):153-63.
2005: Pascal J Goldschmidt-Clermont; Mark A Creager; Douglas Losordo; Douglas W Lorsordo; Gregory K W Lam; Momtaz Wassef; Victor J Dzau
Atherosclerosis 2005: recent discoveries and novel hypotheses.
Circulation 2005;112(21):3348-53.
2005: Kengo Fukushima Kusano; Roberto Pola; Toshinori Murayama; Cynthia Curry; Atsuhiko Kawamoto; Atsushi Iwakura; Satoshi Shintani; Masaaki Ii; Jun Asai; Tengiz Tkebuchava; Tina Thorne; Hideya Takenaka; Ryuichi Aikawa; David Goukassian; Patrick Von Samson; Hiromichi Hamada; Young-sup Yoon; Marcy Silver; Elizabeth Eaton; Hong Ma; Lindsay Heyd; Marianne Kearney; William Munger; Jeffery A Porter; Raj Kishore; Douglas Losordo
Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling.
Nature medicine 2005;11(11):1197-204.
2005: Kazuichi Maruyama; Masaaki Ii; Claus Cursiefen; David G Jackson; Hiroshi Keino; Minoru Tomita; Nico van Rooijen; Hideya Takenaka; Patricia A D'Amore; Joan Stein-Streilein; Douglas Losordo; J Wayne Streilein
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.
The Journal of clinical investigation 2005;115(9):2363-72.
2005: Yoshiaki Tsutsumi; Douglas Losordo
Double face of VEGF.
Circulation 2005;112(9):1248-50.
2005: Masaaki Ii; Hiromi Nishimura; Kengo Fukushima Kusano; Gangjian Qin; Young-sup Yoon; Andrea Wecker; Takayuki Asahara; Douglas Losordo
Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy.
Circulation 2005;112(1):93-102.
2005: Namho Lee; Tina Thorne; Douglas Losordo; Young-sup Yoon
Repair of ischemic heart disease with novel bone marrow-derived multipotent stem cells.
Cell cycle (Georgetown, Tex.) 2005;4(7):861-4.
2005: Raj Kishore; Gangjian Qin; Corinne Luedemann; Evelyn Bord; Allison Hanley; Marcy Silver; Mary Gavin; Young-sup Yoon; David Goukassian; David Goukassain; Douglas Losordo
The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.
The Journal of clinical investigation 2005;115(7):1785-96.
2005: Corinne Luedemann; Evelyn Bord; Gangjian Qin; Yan Zhu; David Goukassian; Douglas Losordo; Raj Kishore
Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanol.
Alcoholism, clinical and experimental research 2005;29(6):930-8.
2005: Rudolf Kirchmair; Dirk H Walter; Masaaki Ii; Kilian Rittig; Anne B Tietz; Toshinori Murayama; Costanza Emanueli; Marcy Silver; Andrea Wecker; Carole Amant; Peter Schratzberger; Young-sup Yoon; Alberto Weber; Eleftheria Panagiotou; Kenneth M Rosen; Ferdinand H Bahlmann; Lester S Adelman; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Circulation 2005;111(20):2662-70.
2005: Shin-ichiro Hayashi; Takayuki Asahara; Haruchika Masuda; Jeffrey M Isner; Douglas Losordo
Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization.
Circulation 2005;111(17):2210-8.
2005: Atsushi Iwakura; Jarrod Dean; Hiromichi Hamada; Elizabeth Eaton; Giangjin Qin; Douglas Losordo; Ryuichi Aikawa
Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells.
Journal of molecular and cellular cardiology 2005;38(5):799-802.
2005: Young-sup Yoon; Shigeki Uchida; Osamu Masuo; Manfred Cejna; Jong-Seon Park; Hyeon-Cheol Gwon; Rudolf Kirchmair; Ferdinand Bahlman; Dirk Walter; Cynthia Curry; Allison Hanley; Jeffrey M Isner; Douglas Losordo
Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor.
Circulation 2005;111(16):2073-85.
2005: Masaaki Ii; Hiromi Nishimura; Atsushi Iwakura; Andrea Wecker; Elizabeth Eaton; Takayuki Asahara; Douglas Losordo
Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity.
Circulation 2005;111(9):1114-20.
2005: MARTA BOSCH; Roberto Pola; Andrea Wecker; Marcy Silver; Alberto Weber; Corinne Luedemann; Cynthia Curry; Toshinori Murayama; Marianne Kearney; Young-sup Yoon; M Rene Malinow; Takayuki Asahara; Jeffrey M Isner; Douglas Losordo
Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia.
Vascular medicine (London, England) 2005;10(1):15-22.
2005: John P Reilly; Mark A Grise; F David Fortuin; Peter Vale; Gary L Schaer; John Lopez; Joseph R VAN Camp; Timothy Henry; Wayne Richenbacher; Douglas Losordo; Richard A Schatz; Jeffrey M Isner
Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients.
Journal of interventional cardiology 2005;18(1):27-31.
2005: Young-sup Yoon; Andrea Wecker; Lindsay Heyd; Jong-Seon Park; Tengiz Tkebuchava; Kengo Kusano; Allison Hanley; Heather Scadova; Gangjian Qin; Dong-Hyun Cha; Kirby L Johnson; Ryuichi Aikawa; Takayuki Asahara; Douglas Losordo
Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.
The Journal of clinical investigation 2005;115(2):326-38.
2005: Pinak B Shah; Douglas Losordo
Non-viral vectors for gene therapy: clinical trials in cardiovascular disease.
Advances in genetics 2005;54():339-61.
2004: Roberto Pola; Tamar R Aprahamian; MARTA BOSCH; Cynthia Curry; Eleonora Gaetani; Andrea Flex; Roy Smith; Jeffrey M Isner; Douglas Losordo
Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves.
Neurobiology of aging 2004;25(10):1361-8.
2004: Kengo Fukushima Kusano; Karen L Allendoerfer; William Munger; Roberto Pola; MARTA BOSCH; Rudolf Kirchmair; Young-sup Yoon; Cynthia Curry; Marcy Silver; Marianne Kearney; Takayuki Asahara; Douglas Losordo
Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):2102-7.
2004: Atsuhiko Kawamoto; Toshinori Murayama; Kengo Kusano; Masaaki Ii; Tengiz Tkebuchava; Satoshi Shintani; Atsushi Iwakura; Ingrid Johnson; Patrick Von Samson; Allison Hanley; Mary Gavin; Cynthia Curry; Marcy Silver; Hong Ma; Marianne Kearney; Douglas Losordo
Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia.
Circulation 2004;110(11):1398-405.
2004: Young-sup Yoon; Ingrid A Johnson; Jong-Seon Park; Larry Diaz; Douglas Losordo
Therapeutic myocardial angiogenesis with vascular endothelial growth factors.
Molecular and cellular biochemistry 2004;264(1-2):63-74.
2004: Rudolf Kirchmair; Margot Egger; Dirk H Walter; Wolfgang Eisterer; Andreas Niederwanger; Ewald Woell; Markus Nagl; Michael T Pedrini; Toshinori Murayama; Silke Frauscher; Allison Hanley; Marcy Silver; Marianne Brodmann; Wolfgang Sturm; Reiner Fischer-Colbrie; Douglas Losordo; Josef R Patsch; Peter Schratzberger
Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.
Circulation 2004;110(9):1121-7.
2004: Dirk H Walter; Manfred Cejna; Larry J Diaz-Sandoval; Sean Willis; Laura Kirkwood; Peter W Stratford; Anne B Tietz; Rudolf Kirchmair; Marcy Silver; Cynthia Curry; Andrea Wecker; Young-sup Yoon; Regina Heidenreich; Allison Hanley; Marianne Kearney; Fermin O Tio; Patrik Kuenzler; Jeffrey M Isner; Douglas Losordo
Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.
Circulation 2004;110(1):36-45.
2004: Raj Kishore; Douglas Losordo
Mending the broken heart: ischemic preconditioning-stimulated myocardial angiogenesis.
Journal of molecular and cellular cardiology 2004;37(1):1-3.
2004: Alberto Weber; Ivan Pedrosa; Atsuhiko Kawamoto; Nathan Himes; Jeeva Munasinghe; Takayuki Asahara; Neil M Rofsky; Douglas Losordo
Magnetic resonance mapping of transplanted endothelial progenitor cells for therapeutic neovascularization in ischemic heart disease.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;26(1):137-43.
2004: Young-sup Yoon; Jong-Seon Park; Tengiz Tkebuchava; Corinne Luedeman; Douglas Losordo
Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction.
Circulation 2004;109(25):3154-7.
2004: Douglas Losordo; Stefanie Dimmeler
Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies.
Circulation 2004;109(22):2692-7.
2004: Peter Moyer; James Feldman; Jon Levine; Joni Beshansky; Harry P Selker; Brien Barnewolt; David F M Brown; Joseph P Cardoza; Shamai A Grossman; Alice Jacobs; Benjamin J Kerman; Carey Kimmelstiel; Richard Larson; Douglas Losordo; Mark Pearlmutter; Charles Pozner; Alberto Ramirez; Kenneth Rosenfield; Thomas Ryan; Richard D Zane; Christopher P Cannon
Implications of the mechanical (PCI) vs thrombolytic controversy for ST segment elevation myocardial infarction on the organization of emergency medical services: the Boston EMS experience.
Critical pathways in cardiology 2004;3(2):53-61.
2004: Douglas Losordo; Stefanie Dimmeler
Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines.
Circulation 2004;109(21):2487-91.
2004: Sara Weis; Satoshi Shintani; Alberto Weber; Rudolf Kirchmair; Malcolm Wood; Adrianna Cravens; Heather McSharry; Atsushi Iwakura; Young-Sup Yoon; Nathan Himes; Deborah Burstein; John Doukas; Richard Soll; Douglas Losordo; David A Cheresh
Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction.
The Journal of clinical investigation 2004;113(6):885-94.
2004: Roberto Pola; Eleonora Gaetani; Andrea Flex; Tamar R Aprahamian; MARTA BOSCH; Douglas Losordo; Roy Smith; Paolo Pola
Comparative analysis of the in vivo angiogenic properties of stable prostacyclin analogs: a possible role for peroxisome proliferator-activated receptors.
Journal of molecular and cellular cardiology 2004;36(3):363-70.
2004: Rudolf Kirchmair; Roland Gander; Margot Egger; Allison Hanley; Marcy Silver; Andreas Ritsch; Toshinori Murayama; Nicole Kaneider; Wolfgang Sturm; Marianne Kearny; Reiner Fischer-Colbrie; Brigitte Kircher; Hannes Gaenzer; Christian Wiedermann; Allan H Ropper; Douglas Losordo; Josef R Patsch; Peter Schratzberger
The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo.
Circulation 2004;109(6):777-83.
2003: Masaaki Ii; Douglas Losordo
Transplant graft vasculopathy: a dark side of bone marrow stem cells?
Circulation 2003;108(25):3056-8.
2003: Atsushi Iwakura; Corinne Luedemann; Shubha Shastry; Allison Hanley; Marianne Kearney; Ryuichi Aikawa; Jeffrey M Isner; Takayuki Asahara; Douglas Losordo
Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury.
Circulation 2003;108(25):3115-21.
2003: Raj Kishore; Corinne Luedemann; Evelyn Bord; David Goukassian; Douglas Losordo
Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways.
Circulation research 2003;93(10):932-40.
2003: F David Fortuin; Peter Vale; Douglas Losordo; James Symes; Giacomo A DeLaria; J Jeffrey Tyner; Gary L Schaer; Robert March; R Jeffrey Snell; Timothy D Henry; Joseph Van Camp; John J Lopez; Wayne Richenbacher; Jeffrey M Isner; Richard A Schatz
One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients.
The American journal of cardiology 2003;92(4):436-9.
2003: Roberto Pola; Leona E Ling; Tamar R Aprahamian; Elena Barban; MARTA BOSCH; Cynthia Curry; Michael Corbley; Marianne Kearney; Jeffrey M Isner; Douglas Losordo
Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.
Circulation 2003;108(4):479-85.
2003: Young-sup Yoon; Douglas Losordo
All in the family: VEGF-B joins the ranks of proangiogenic cytokines.
Circulation research 2003;93(2):87-90.
2003: David Goukassian; Raj Kishore; Kevin Krasinski; Christine Dolan; Corinne Luedemann; Young-sup Yoon; Marianne Kearney; Allison Hanley; Hong Ma; Takayuki Asahara; Jeffrey M Isner; Douglas Losordo
Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth.
Circulation research 2003;93(2):162-9.
2003: Larry J Diaz-Sandoval; Douglas Losordo
Gene therapy for cardiovascular angiogenesis.
Expert opinion on biological therapy 2003;3(4):599-616.
2003: Douglas Losordo; Jeffrey M Isner; Larry J Diaz-Sandoval
Endothelial recovery: the next target in restenosis prevention.
Circulation 2003;107(21):2635-7.
2003: Jun-ichi Yamaguchi; Kengo Fukushima Kusano; Osamu Masuo; Atsuhiko Kawamoto; Marcy Silver; Satoshi Murasawa; MARTA BOSCH; Haruchika Masuda; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.
Circulation 2003;107(9):1322-8.
2003: Young-sup Yoon; Toshinori Murayama; Edwin Gravereaux; Tengiz Tkebuchava; Marcy Silver; Cynthia Curry; Andrea Wecker; Rudolf Kirchmair; Chun Song Hu; Marianne Kearney; Alan Ashare; David G Jackson; Hajime Kubo; Jeffrey M Isner; Douglas Losordo
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.
The Journal of clinical investigation 2003;111(5):717-25.
2003: Atsuhiko Kawamoto; Tengiz Tkebuchava; Jun-ichi Yamaguchi; Hiromi Nishimura; Young-sup Yoon; Charles E Milliken; Shigeki Uchida; Osamu Masuo; Hideki Iwaguro; Hong Ma; Allison Hanley; Marcy Silver; Marianne Kearney; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.
Circulation 2003;107(3):461-8.
2003: Peter Schratzberger; Rudolf Kirchmair; Peter Vale; Douglas Losordo
Therapeutic angiogenesis by gene transfer in critical limb and myocardial ischemia.
Current pharmaceutical design 2003;9(13):1041-7.
2002: Douglas Losordo; Atsuhiko Kawamoto
Biological revascularization and the interventional molecular cardiologist: bypass for the next generation.
Circulation 2002;106(24):3002-5.
2002: Peter Schratzberger; Joseph G Krainin; Gabriele Schratzberger; Marcy Silver; Hong Ma; Marianne Kearney; Robert F Zuk; Axel F Brisken; Douglas Losordo; Jeffrey M Isner
Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):576-83.
2002: Saul B Freedman; Peter Vale; Christoph Kalka; Marianne Kearney; Anne Pieczek; James Symes; Douglas Losordo; Jeffrey M Isner
Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA.
Human gene therapy 2002;13(13):1595-603.
2002: Satoshi Murasawa; Joan Llevadot; Marcy Silver; Jeffrey M Isner; Douglas Losordo; Takayuki Asahara
Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells.
Circulation 2002;106(9):1133-9.
2002: Raj Kishore; Ioakim Spyridopoulos; Corinne Luedemann; Douglas Losordo
Functionally novel tumor necrosis factor-alpha-modulated CHR-binding protein mediates cyclin A transcriptional repression in vascular endothelial cells.
Circulation research 2002;91(4):307-14.
2002: Toshinori Murayama; Oren M Tepper; Marcy Silver; Hong Ma; Douglas Losordo; Jeffery M Isner; Takayuki Asahara; Christoph Kalka
Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo.
Experimental hematology 2002;30(8):967-72.
2002: Atsuhiko Kawamoto; Takayuki Asahara; Douglas Losordo
Transplantation of endothelial progenitor cells for therapeutic neovascularization.
Cardiovascular radiation medicine 2002;3(3-4):221-5.
2002: Dirk H Walter; Kilian Rittig; Ferdinand H Bahlmann; Rudolf Kirchmair; Marcy Silver; Toshinori Murayama; Hiromi Nishimura; Douglas Losordo; Takayuki Asahara; Jeffrey M Isner
Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.
Circulation 2002;105(25):3017-24.
2002: Ioakim Spyridopoulos; Corinne Luedemann; Donghui Chen; Marianne Kearney; Dongfen Chen; Toyoaki Murohara; Nicole Principe; Jeffrey M Isner; Douglas Losordo
Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):901-6.
2002: john cooke; Douglas Losordo
Nitric oxide and angiogenesis.
Circulation 2002;105(18):2133-5.
2002: Douglas Losordo; Peter Vale; Robert Charles Hendel; Charles E Milliken; F David Fortuin; Nancie Cummings; Richard A Schatz; Takayuki Asahara; Jeffrey M Isner; Richard E Kuntz
Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
Circulation 2002;105(17):2012-8.
2002: Ioakim Spyridopoulos; Jeffrey M Isner; Douglas Losordo
Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1).
Basic research in cardiology 2002;97(2):117-24.
2002: Larry J Diaz-Sandoval; Bernard D Kosowsky; Douglas Losordo
Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial).
The American journal of cardiology 2002;89(3):356-8.
2002: Riyaz Bashir; Peter Vale; Jeffrey M Isner; Douglas Losordo
Angiogenic gene therapy: pre-clinical studies and phase I clinical data.
Kidney international 2002;61(1 Suppl):S110-4.
2001: Sharon C Francis; Mohan K Raizada; Abeel A Mangi; Luis G Melo; Victor J Dzau; Peter Vale; J M Isner; Douglas Losordo; Julie Chao; Michael J Katovich; Kathleen H Berecek
Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb?
Physiological genomics 2001;7(2):79-94.
2001: C Amant; P Holm; S H Xu Sh; N Tritman; M Kearney; Douglas Losordo
Estrogen receptor-mediated, nitric oxide-dependent modulation of the immunologic barrier function of the endothelium: regulation of fas ligand expression by estradiol.
Circulation 2001;104(21):2576-81.
2001: Timothy D Henry; Krishna Rocha-Singh; Jeffrey M Isner; D J Kereiakes; Frank J Giordano; M Simons; Douglas Losordo; Robert Charles Hendel; R O Bonow; S M Eppler; Thomas F Zioncheck; E B Holmgren; Ted McCluskey
Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.
American heart journal 2001;142(5):872-80.
2001: Kevin Krasinski; I Spyridopoulos; Marianne Kearney; Douglas Losordo
In vivo blockade of tumor necrosis factor-alpha accelerates functional endothelial recovery after balloon angioplasty.
Circulation 2001;104(15):1754-6.
2001: Peter Vale; Douglas Losordo; James Symes; Jeffrey M Isner
[Growth factors for therapeutic angiogenesis in cardiovascular diseases].
Revista española de cardiología 2001;54(10):1210-24.
2001: Jeffrey M Isner; Peter Vale; James Symes; Douglas Losordo
Assessment of risks associated with cardiovascular gene therapy in human subjects.
Circulation research 2001;89(5):389-400.
2001: Douglas Losordo; J M Isner
Vascular endothelial growth factor-induced angiogenesis: crouching tiger or hidden dragon?
Journal of the American College of Cardiology 2001;37(8):2131-5.
2001: Peter Vale; Douglas Losordo; Charles E Milliken; M C McDonald; L M Gravelin; C M Curry; DD Esakof; M Maysky; James Symes; Jeffrey M Isner
Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.
Circulation 2001;103(17):2138-43.
2001: Douglas Losordo; J M Isner
Estrogen and angiogenesis: A review.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(1):6-12.
2001: KG Lathi; Peter Vale; Douglas Losordo; R M Cespedes; James Symes; DD Esakof; M Maysky; J M Isner
Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease: anesthetic management and results.
Anesthesia and analgesia 2001;92(1):19-25.
2000: Peter Vale; Douglas Losordo; Charles E Milliken; M Maysky; DD Esakof; James Symes; Jeffrey M Isner
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia.
Circulation 2000;102(9):965-74.
1999: Peter Vale; Douglas Losordo; Charles E Milliken; DD Esakof; Jeffrey M Isner
Images in Cardiovascular Medicine: Percutaneous myocardial gene transfer of phVEGF-2.
Circulation 1999;100(24):2462-3.
1999: DD Esakof; M Maysky; Douglas Losordo; Peter Vale; KG Lathi; J O Pastore; James Symes; Jeffrey M Isner
Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris.
Human gene therapy 1999;10(14):2307-14.
1999: James Symes; Douglas Losordo; Peter Vale; KG Lathi; DD Esakof; M Mayskiy; Jeffrey M Isner
Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease.
The Annals of thoracic surgery 1999;68(3):830-6; discussion 836-7.
1999: Douglas Losordo; Peter Vale; Jeffrey M Isner
Gene therapy for myocardial angiogenesis.
American heart journal 1999;138(2 Pt 2):S132-41.
1999: Peter Vale; Douglas Losordo; Tengiz Tkebuchava; D Chen; Charles E Milliken; Jeffrey M Isner
Catheter-based myocardial gene transfer utilizing nonfluoroscopic electromechanical left ventricular mapping.
Journal of the American College of Cardiology 1999;34(1):246-54.
1999: Ik-Kyung Jang; David F M Brown; Robert P Giugliano; H V Anderson; Douglas Losordo; José Carlos Nicolau; O P Dutra; O Bazzino; V M Viamonte; R Norbady; A S Liprandi; T J Massey; Robert Dinsmore; R P Schwarz
A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study.
Journal of the American College of Cardiology 1999;33(7):1879-85.
1999: Toyoaki Murohara; B Witzenbichler; Ioakim Spyridopoulos; Takayuki Asahara; B Ding; A Sullivan; Douglas Losordo; Jeffrey M Isner
Role of endothelial nitric oxide synthase in endothelial cell migration.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1156-61.
1999: J M Isner; Douglas Losordo
Therapeutic angiogenesis for heart failure.
Nature medicine 1999;5(5):491-2.
1998: Ioakim Spyridopoulos; Nicole Principe; Kevin Krasinski; Sh Xu; Marianne Kearney; M Magner; Jeffrey M Isner; Douglas Losordo
Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis.
Circulation 1998;98(25):2883-90.
1998: Douglas Losordo; Peter Vale; James Symes; C H Dunnington; DD Esakof; M Maysky; A B Ashare; KG Lathi; Jeffrey M Isner
Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.
Circulation 1998;98(25):2800-4.
1997: Ioakim Spyridopoulos; Edi Brogi; Marianne Kearney; A B Sullivan; C Cetrulo; Jeffrey M Isner; Douglas Losordo
Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.
Journal of molecular and cellular cardiology 1997;29(5):1321-30.
1997: thierry couffinhal; Marianne Kearney; B Witzenbichler; D Chen; Toyoaki Murohara; Douglas Losordo; James Symes; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.
The American journal of pathology 1997;150(5):1673-85.
1997: Marianne Kearney; Anne Pieczek; L Haley; Douglas Losordo; V Andres; Robert M Schainfeld; Kenneth Rosenfield; Jeffrey M Isner
Histopathology of in-stent restenosis in patients with peripheral artery disease.
Circulation 1997;95(8):1998-2002.
1997: Kevin Krasinski; I Spyridopoulos; Takayuki Asahara; R van der Zee; Jeffrey M Isner; Douglas Losordo
Estradiol accelerates functional endothelial recovery after arterial injury.
Circulation 1997;95(7):1768-72.
1997: I Spyridopoulos; A B Sullivan; Marianne Kearney; Jeffrey M Isner; Douglas Losordo
Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor.
Circulation 1997;95(6):1505-14.
1996: K Baysal; Douglas Losordo
Oestrogen receptors and cardiovascular disease.
Clinical and experimental pharmacology & physiology 1996;23(6-7):537-48.
1996: J Geoffrey Pickering; S Takeshita; L Feldman; Douglas Losordo; Jeffrey M Isner
Vascular applications of human gene therapy.
Seminars in interventional cardiology : SIIC 1996;1(1):84-8.
1994: S Takeshita; Douglas Losordo; Marianne Kearney; S T Rossow; Jeffrey M Isner
Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model.
Laboratory investigation; a journal of technical methods and pathology 1994;71(3):387-91.
1994: Douglas Losordo; Kenneth Rosenfield; J Kaufman; Anne Pieczek; Jeffrey M Isner
Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound.
Circulation 1994;89(6):2570-7.
1994: Douglas Losordo; Marianne Kearney; E A Kim; J Jekanowski; Jeffrey M Isner
Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.
Circulation 1994;89(4):1501-10.
1994: Douglas Losordo; J Geoffrey Pickering; S Takeshita; G Leclerc; D Gal; L Weir; Marianne Kearney; J Jekanowski; Jeffrey M Isner
Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression.
Circulation 1994;89(2):785-92.
1994: J Geoffrey Pickering; J Jekanowski; L Weir; S Takeshita; Douglas Losordo; Jeffrey M Isner
Liposome-mediated gene transfer into human vascular smooth muscle cells.
Circulation 1994;89(1):13-21.
1994: K Hogan; K Ramaswamy; Douglas Losordo; Jeffrey M Isner
Pathology of mitral commissurotomy performed with the Inoue catheter: implications for mechanisms and complications.
Catheterization and cardiovascular diagnosis 1994;Suppl 2():42-51.
1993: Douglas Losordo; J O Pastore; D Coletta; D Kenny; Jeffrey M Isner
Limitations of color flow Doppler imaging in the quantification of valvular regurgitation: velocity of regurgitant jet, rather than volume, determines size of color Doppler image.
American heart journal 1993;126(1):168-76.
1992: Douglas Losordo; Kenneth Rosenfield; Anne Pieczek; K Baker; M Harding; Jeffrey M Isner
How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound.
Circulation 1992;86(6):1845-58.
1991: Kenneth Rosenfield; Douglas Losordo; K Ramaswamy; J O Pastore; R E Langevin; S Razvi; B D Kosowsky; Jeffrey M Isner
Three-dimensional reconstruction of human coronary and peripheral arteries from images recorded during two-dimensional intravascular ultrasound examination.
Circulation 1991;84(5):1938-56.
1991: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo; L Rose; R E Langevin; S Razvi; B D Kosowsky
Combination balloon-ultrasound imaging catheter for percutaneous transluminal angioplasty. Validation of imaging, analysis of recoil, and identification of plaque fracture.
Circulation 1991;84(2):739-54.
1990: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo
Excimer laser atherectomy. The greening of Sisyphus.
Circulation 1990;81(6):2018-21.
1990: Jeffrey M Isner; Douglas Losordo; Kenneth Rosenfield; K Ramaswamy; S Kelly; J O Pastore; B D Kosowsky
Catheter-based intravascular ultrasound discriminates bicuspid from tricuspid valves in adults with calcific aortic stenosis.
Journal of the American College of Cardiology 1990;15(6):1310-7.
1990: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo; S Kelly; P Palefski; R E Langevin; S Razvi; J O Pastore; B D Kosowsky
Percutaneous intravascular US as adjunct to catheter-based interventions: preliminary experience in patients with peripheral vascular disease.
Radiology 1990;175(1):61-70.
1989: Douglas Losordo; K Ramaswamy; Kenneth Rosenfield; Jeffrey M Isner
Use of emergency balloon dilation to reverse acute hemodynamic decompensation developing during diagnostic catheterization for aortic stenosis (bailout valvuloplasty).
The American journal of cardiology 1989;63(5):388-9.
1987: I Lipinska; V Gurewich; C M Meriam; B D Kosowsky; K Ramaswamy; Edward F Philbin; Douglas Losordo
Lipids, lipoproteins, fibrinogen and fibrinolytic activity in angiographically assessed coronary heart disease.
Artery 1987;15(1):44-60.