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T Akiyama

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T Ishidate; Akihiko Matsumine; K Toyoshima; T Akiyama
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.
Hidewaki Nakagawa; K Koyama; Yuji Murata; M Morito; T Akiyama; Yusuke Nakamura
EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.
Hidewaki Nakagawa; K Koyama; Yuji Murata; M Morito; T Akiyama; Yusuke Nakamura
APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.

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All Publications

2000: T Ishidate; Akihiko Matsumine; K Toyoshima; T Akiyama
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.
Oncogene 2000;19(3):365-72.
2000: Hidewaki Nakagawa; K Koyama; Yuji Murata; M Morito; T Akiyama; Yusuke Nakamura
EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue.
Oncogene 2000;19(2):210-6.
2000: Hidewaki Nakagawa; K Koyama; Yuji Murata; M Morito; T Akiyama; Yusuke Nakamura
APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.
Cancer research 2000;60(1):101-5.
1999: Takao Senda; A Matsumine; H Yanai; T Akiyama
Localization of MCC (mutated in colorectal cancer) in various tissues of mice and its involvement in cell differentiation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(9):1149-58.
1999: F Hamada; Yuji Murata; A Nishida; Fumiko Fujita; Y Tomoyasu; M Nakamura; K Toyoshima; T Tabata; N Ueno; T Akiyama
Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(8):465-74.
1999: F Hamada; Y Tomoyasu; Y Takatsu; M Nakamura; S Nagai; A Suzuki; Fumiko Fujita; H Shibuya; K Toyoshima; N Ueno; T Akiyama
Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.
Science (New York, N.Y.) 1999;283(5408):1739-42.
1998: Hidewaki Nakagawa; Yuji Murata; K Koyama; A Fujiyama; Yasuo Miyoshi; Morito Monden; T Akiyama; Yusuke Nakamura
Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.
Cancer research 1998;58(22):5176-81.
1998: Tadashi Nakamura; F Hamada; T Ishidate; K Anai; K Kawahara; K Toyoshima; T Akiyama
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(6):395-403.
1998: K Inoue; Hiroya Tamaki; Hiroyasu Ogawa; Yoshihiro Oka; Toshihiro Soma; Toyoshi Tatekawa; Yusuke Oji; Akihiro Tsuboi; Eui Ho Kim; Manabu Kawakami; T Akiyama; Tadamitsu Kishimoto; Haruo Sugiyama
Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.
Blood 1998;91(8):2969-76.
1998: Tamotsu Yamagami; Hiroyasu Ogawa; Hiroya Tamaki; Yusuke Oji; Toshihiro Soma; Yoshihiro Oka; Toyoshi Tatekawa; Akihiro Tsuboi; Eui Ho Kim; T Akiyama; Haruo Sugiyama
Suppression of Wilms' tumor gene (WT1) expression induces G2/M arrest in leukemic cells.
Leukemia research 1998;22(4):383-4.
1998: K Mori; Kyoko Iwao; Yasuo Miyoshi; A Nakagawara; K Kofu; T Akiyama; N Arita; T Hayakawa; Yusuke Nakamura
Identification of brain-specific splicing variants of the hDLG1 gene and altered splicing in neuroblastoma cell lines.
Journal of human genetics 1998;43(2):123-7.
1997: T Akiyama
[APC, beta-catenin, DLG].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1432-5.
1997: T Akiyama
[The Wilms' tumor suppressor gene WT1].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1612-7.
1997: T Ishidate; Satoshi Yoshihara; Y Kawasaki; B C Roy; K Toyoshima; T Akiyama
Identification of a novel nuclear localization signal in Sam68.
FEBS letters 1997;409(2):237-41.
1997: Yuji Murata; T Kudoh; Haruo Sugiyama; K Toyoshima; T Akiyama
The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells.
FEBS letters 1997;409(1):41-5.
1997: K Satoh; H Yanai; T Senda; K Kohu; Tadashi Nakamura; N Okumura; Akihiko Matsumine; Shouhei Kobayashi; K Toyoshima; T Akiyama
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.
Genes to cells : devoted to molecular & cellular mechanisms 1997;2(6):415-24.
1997: Y Dobashi; T Kudoh; T Ishidate; M Shoji; K Toyoshima; T Akiyama
The Wilms tumor protein is persistently associated with the nuclear matrix throughout the cell cycle.
Molecular and cellular biochemistry 1997;171(1-2):121-6.
1996: T Kudoh; T Ishidate; Tadashi Nakamura; K Toyoshima; T Akiyama
Constitutive expression of the Wilms tumor suppressor gene WT1 in F9 embryonal carcinoma cells induces apoptotic cell death in response to retinoic acid.
Oncogene 1996;13(7):1431-9.
1996: I Miyashiro; T Kaname; T Nakayama; S Nakamori; T Yagyu; Takushi Monden; N Kikkawa; I Nishisho; T Muramatsu; Morito Monden; T Akiyama
Expression of truncated midkine in human colorectal cancers.
Cancer letters 1996;106(2):287-91.
1996: Y Dobashi; R N Bhattacharjee; K Toyoshima; T Akiyama
Upregulation of the APC gene product during neuronal differentiation of rat pheochromocytoma PC12 cells.
Biochemical and biophysical research communications 1996;224(2):479-83.
1996: Takao Senda; I Miyashiro; A Matsumine; G H Baeg; T Monden; S Kobayashil; Morito Monden; K Toyoshima; T Akiyama
The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells.
Biochemical and biophysical research communications 1996;223(2):329-34.
1996: A Matsumine; A Ogai; Takao Senda; N Okumura; K Satoh; G H Baeg; T Kawahara; S Kobayashi; M Okada; K Toyoshima; T Akiyama
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.
Science (New York, N.Y.) 1996;272(5264):1020-3.
1996: A Matsumine; Takao Senda; G H Baeg; B C Roy; Y Nakamura; M Noda; K Toyoshima; T Akiyama
MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase.
The Journal of biological chemistry 1996;271(17):10341-6.
1996: Y Dobashi; T Kudoh; K Toyoshima; T Akiyama
Persistent activation of CDK4 during neuronal differentiation of rat pheochromocytoma PC12 cells.
Biochemical and biophysical research communications 1996;221(2):351-5.
1996: T Akiyama
[The APC gene].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(4):955-9.
1996: Tamotsu Yamagami; Haruo Sugiyama; K Inoue; Hiroyasu Ogawa; Toyoshi Tatekawa; M Hirata; T Kudoh; T Akiyama; A Murakami; T Maekawa
Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis.
Blood 1996;87(7):2878-84.
1996: R N Bhattacharjee; F Hamada; K Toyoshima; T Akiyama
The tumor suppressor gene product APC is hyperphosphorylated during the M phase.
Biochemical and biophysical research communications 1996;220(1):192-5.
1995: G H Baeg; A Matsumine; T Kuroda; R N Bhattacharjee; I Miyashiro; K Toyoshima; T Akiyama
The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.
The EMBO journal 1995;14(22):5618-25.
1995: T Akiyama
[Structure and function of tumor suppressor genes].
Nihon rinsho. Japanese journal of clinical medicine 1995;53(11):2654-9.
1995: Y Dobashi; T Kudoh; A Matsumine; K Toyoshima; T Akiyama
Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells.
The Journal of biological chemistry 1995;270(39):23031-7.
1995: T Kudoh; T Ishidate; M Moriyama; K Toyoshima; T Akiyama
G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4517-21.
1994: T Akiyama
[Cell cycle regulation by anti-oncogene].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(12):2158-62.
1994: S Kamada; K Toyoshima; T Akiyama
Serum-independent phosphorylation of c-Jun and alterations in AP-1 components by transformation with various oncogenes.
The Journal of biological chemistry 1994;269(6):4565-70.
1993: M Aoki; F Hamada; T Sugimoto; S Sumida; T Akiyama; K Toyoshima
The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation.
The Journal of biological chemistry 1993;268(30):22723-32.
1993: T Akiyama
[Functions of antioncogene products].
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(10):1429-34.
1993: F Hamada; M Aoki; T Akiyama; K Toyoshima
Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6305-9.
1993: E Savoysky; Motoshi Suzuki; C Simbulan; K Tamai; T Ohuchi; T Akiyama; Shonen Yoshida
Immunopurified Rb protein inhibits SV40 T antigen-dependent stimulation of DNA polymerase alpha.
Oncogene 1993;8(2):319-25.
1992: T Akiyama; T Ohuchi; S Sumida; S Q Xu; K Toyoshima
Phosphorylation of the anti-oncogene products and control of the cell cycle.
The Tohoku journal of experimental medicine 1992;168(2):153-7.
1992: E Savoysky; Motoshi Suzuki; K Tamai; T Sakurai; T Ohuchi; T Akiyama; K Kojima; Shonen Yoshida
Efficient purification of a full length and biochemically active p110Rb, the retinoblastoma gene product.
Biochemical and biophysical research communications 1992;187(2):697-702.
1992: T Akiyama; T Ohuchi; S Sumida; K Matsumoto; K Toyoshima
Phosphorylation of the retinoblastoma protein by cdk2.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7900-4.
1992: K Toyoshima; T Akiyama
[Progress in oncogene and antioncogene research].
Gan to kagaku ryoho. Cancer & chemotherapy 1992;19(6):751-6.
1992: K Toyoshima; Y Yamanashi; K Inoue; K Semba; T Yamamoto; T Akiyama
Protein tyrosine kinases belonging to the src family.
Ciba Foundation symposium 1992;164():240-8; discussion 248-53.
1991: K Inoue; B Wongsasant; T Akiyama; K Toyoshima
Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells.
Molecular and cellular biology 1991;11(12):6279-85.
1991: M Aoki; T Akiyama; J Miyoshi; K Toyoshima
Identification and characterization of protein products of the cot oncogene with serine kinase activity.
Oncogene 1991;6(9):1515-9.
1991: T Akiyama; S Matsuda; Y Namba; T Saito; K Toyoshima; T Yamamoto
The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.
Molecular and cellular biology 1991;11(2):833-42.