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Dennis Burton

Research Profile

Living Beings

HIV-1

Chemicals & Drugs

Procedures

Neutralization Tests

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TOP 3
Joseph Jardine; Meaghan Jones; Jean-Philippe Julien; Oleksandr Kalyuzhniy; Skye MacPherson; John C Mathison; Andrew McGuire; Sergey Menis; David Nemazee; Travis Nieusma; Takayuki Ota; Devin Sok; Leonidas Stamatatos; Andrew B Ward; Ian A Wilson; David Baker; Dennis R Burton; Po-Ssu Huang; William R Schief
Rational HIV immunogen design to target specific germline B cell receptors.
Jean-Philippe Julien; Umesh Katpally; Reza Khayat; Jeong Hyun Lee; Andre J Marozsan; Ryan McBride; John P Moore; James C Paulson; Robert Pejchal; Pascal Poignard; Alejandra Ramos; Rogier W Sanders; Devin Sok; Robyn L Stanfield; Laura M Walker; Andrew B Ward; Dennis R Burton; Albert Cupo; Rafael S Depetris; Devan C Diwanji; Katie J Doores; Ian A Wilson
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
Julia Gavrilyuk; Avinash Oza; Karen Saye-Francisco; Michael S Seaman; Shannon J Sirk; Hisatoshi Uehara; Elise Zablowsky; Hitoshi Ban; Dennis R Burton; Angelica Cuevas; Carlos F Barbas
Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG.

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All Publications

2013: Joseph Jardine; Meaghan Jones; Jean-Philippe Julien; Oleksandr Kalyuzhniy; Skye MacPherson; John C Mathison; Andrew McGuire; Sergey Menis; David Nemazee; Travis Nieusma; Takayuki Ota; Devin Sok; Leonidas Stamatatos; Andrew B Ward; Ian A Wilson; David Baker; Dennis R Burton; Po-Ssu Huang; William R Schief
Rational HIV immunogen design to target specific germline B cell receptors.
Science (New York, N.Y.) 2013;340(6133):711-6.
2013: Jean-Philippe Julien; Umesh Katpally; Reza Khayat; Jeong Hyun Lee; Andre J Marozsan; Ryan McBride; John P Moore; James C Paulson; Robert Pejchal; Pascal Poignard; Alejandra Ramos; Rogier W Sanders; Devin Sok; Robyn L Stanfield; Laura M Walker; Andrew B Ward; Dennis R Burton; Albert Cupo; Rafael S Depetris; Devan C Diwanji; Katie J Doores; Ian A Wilson
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
PLoS pathogens 2013;9(5):e1003342.
2013: Julia Gavrilyuk; Avinash Oza; Karen Saye-Francisco; Michael S Seaman; Shannon J Sirk; Hisatoshi Uehara; Elise Zablowsky; Hitoshi Ban; Dennis R Burton; Angelica Cuevas; Carlos F Barbas
Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG.
Journal of virology 2013;87(9):4985-93.
2013: Katie J Doores; Colleen Doyle-Cooper; Michael Huber; Khoa M Le; David Nemazee; Ralph Pantophlet; Sheng-Kai Wang; Chi-Huey Wong; Anthony Cooper; Dennis R Burton
2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.
Journal of virology 2013;87(4):2234-41.
2013: Marie Pancera; Jonathan Stuckey; Yongping Yang; Jiang Zhu; Dennis R Burton; Jason Gorman; Wayne C Koff; Mark K Louder; Gabriel Lu; John R Mascola; Jason S McLellan; Peter D Kwong
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.
PloS one 2013;8(2):e55701.
2012: Takayuki Ota; Pascal Poignard; William R Schief; Devin Sok; Xueling Wu; Richard Wyatt; James M Binley; Dennis R Burton; Bimal K Chakrabarti; Anthony B Cooper; Katie J Doores; Colleen Doyle-Cooper; Emilia Falkowska; Lars Hangartner; Michael Huber; Joseph Jardine; Khoa Le; Jeffrey Lifson; John R Mascola; David Nemazee
Anti-HIV B Cell lines as candidate vaccine biosensors.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4816-24.
2012: Brian Moldt; Shari M Piaskowski; Pascal Poignard; Eva G Rakasz; Niccole Schultz; Kristine Swiderek; David I Watkins; Kimberly L Weisgrau; Zachary Bergman; Po-Ying Chan-Hui; Dennis R Burton
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(46):18921-5.
2012: Dennis R Burton; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Rafi Ahmed; Dan H Barouch; Richard Wyatt
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe 2012;12(4):396-407.
2012: Nicole A Doria-Rose; Ivelin Georgiev; Jason Gorman; Barton F Haynes; Wayne C Koff; Peter D Kwong; Jason S McLellan; Sijy O'Dell; Marie Pancera; Ryan P Staupe; Mattia Bonsignori; Dennis R Burton; Gwo-Yu Chuang; John R Mascola
A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
Journal of virology 2012;86(15):8319-23.
2012: Dennis R Burton; Pascal Poignard; Robyn L Stanfield; Ian A Wilson
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Science (New York, N.Y.) 2012;337(6091):183-6.
2012: Leopold Kong; Dennis R Burton; Erick Giang; Justin B Robbins; Robyn L Stanfield; Ian A Wilson; Mansun Law
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9499-504.
2012: Brian Moldt; Falk Nimmerjahn; Paul W H I Parren; Pascal Poignard; Eva G Rakasz; Jörn E Schmitz; Niccole Schultz; Mami Shibata-Koyama; David Watkins; Anne-Sophie Dugast; D Cameron Dunlop; David T Evans; Samantha L Finstad; Donald N Forthal; Ann J Hessell; Shigeru Iida; Chenggang Jin; Yutaka Kanda; Gary Landucci; Michael D Alpert; Galit Alter; Dennis R Burton
A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques.
Journal of virology 2012;86(11):6189-96.
2012: Erick Giang; Alexander Ploss; Jannick C Prentoe; Charles M Rice; Jens Bukh; Dennis R Burton; Marcus Dorner; Marlène Dreux; Matthew J Evans; Mansun Law
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6205-10.
2012: Jiang Zhu; Dennis R Burton; Wayne C Koff; John R Mascola; James C Mullikin; Sijy O'Dell; Gilad Ofek; Marie Pancera; Lawrence Shapiro; Melissa Simek; Xueling Wu; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics.
Frontiers in microbiology 2012;3():315.
2012: Pascal Poignard; Eva G Rakasz; David I Watkins; Noëlie Campos; Karla Maloveste; Brian Moldt; William C Olson; Dennis R Burton
Protection against high-dose highly pathogenic mucosal SIV challenge at very low serum neutralizing titers of the antibody-like molecule CD4-IgG2.
PloS one 2012;7(7):e42209.
2011: Victoria Wahl-Jensen; Lukas K Buehler; Dennis R Burton; Jean da Silva Correia; Victor DeFilippis; Friedericke Feldmann; Klaus Früh; Jason Kindrachuk; Jens H Kuhn; Sabine Kurz; Heinz Feldmann
Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.
PLoS neglected tropical diseases 2011;5(10):e1359.
2011: Brian Moldt; Pascal Poignard; Niccole Schultz; Michael D Alpert; D Cameron Dunlop; David T Evans; Jackson D Harvey; Ann J Hessell; Dennis R Burton
A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV.
Journal of virology 2011;85(20):10572-81.
2011: Laura M Walker; Sheng-Kai Wang; Ian A Wilson; Chi-Huey Wong; Terri Wrin; Alejandra Ramos; Melissa D Simek; Dennis R Burton; Po-Ying Chan-Hui; Katie J Doores; Emilia Falkowska; Steven Fling; Phillip W Hammond; Michael Huber; Jean-Philippe Julien; Wayne C Koff; Jennifer L Mitcham; Matthew Moyle; Ole A Olsen; Robert Pejchal; Sanjay Phogat; Pham Phung; Pascal Poignard
Broad neutralization coverage of HIV by multiple highly potent antibodies.
Nature 2011;477(7365):466-70.
2011: Johannes F Scheid; Michael S Seaman; Beatrix Ueberheide; Klara Velinzon; Bruce D Walker; Thiago Y K Oliveira; Florencia Pereyra; John Pietzsch; Pascal Poignard; Alexander Abadir; Pamela J Bjorkman; Farid Boulad; Dennis R Burton; Brian T Chait; Ron Diskin; David Fenyo; David D Ho; Arlene Hurley; Florian Klein; Hugo Mouquet; Sunnie Myung; Michel C Nussenzweig
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science (New York, N.Y.) 2011;333(6049):1633-7.
2011: B K Chakrabarti; A Ghobbeh; J F Guenaga; Pascal Poignard; L M Walker; Dennis R Burton; Richard Wyatt
Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity.
Journal of virology 2011;85(16):8217-26.
2011: Dennis R Burton; Lisa Cavacini; Lara A Doyle; D Cameron Dunlop; Ann J Hessell; Brandon F Keele; Thomas A Ketas; Per Johan Klasse; Brian Moldt; Pascal Poignard; Ronald S Veazey; John P Moore
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(27):11181-6.
2011: Marcus Dorner; Qian Feng; Joshua A Horwitz; Christopher T Jones; Mansun Law; Kathy Mu; Walter T Barry; Dennis R Burton; Maria Teresa Catanese; Charles M Rice; Justin B Robbins; John W Schoggins; Alexander Ploss
A genetically humanized mouse model for hepatitis C virus infection.
Nature 2011;474(7350):208-11.
2011: Kyriacos C Nicolaou; Silvano Sanchini; David Sarlah; Gang Lu; T Robert Wu; Daniel K. Nomura; Benjamin F Cravatt; Beatrice Cubitt; Juan Carlos de la Torre; Ann J Hessell; Dennis R Burton
Design, synthesis, and biological evaluation of a biyouyanagin compound library.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6715-20.
2011: Camille Bonomelli; Dennis R Burton; Max Crispin; Katie J Doores; D Cameron Dunlop; Raymond A Dwek; Victoria Thaney; Christopher N Scanlan
The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.
PloS one 2011;6(8):e23521.
2011: Nitish Agrawal; Junya Akagi; Katherine Bauer; Dennis R Burton; Sean X Du; Heather Kinkead; Daniel P Leaman; Raman Nohria; Eric Rowcliffe; Robert G Whalen; Michael B Zwick
Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1).
PloS one 2011;6(6):e21339.
2010: Dennis R Burton
Scaffolding to build a rational vaccine design strategy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):17859-60.
2010: Julia Gavrilyuk; Hisatoshi Uehara; Nobumasa Otsubo; Ann Hessell; Dennis R Burton; Carlos F Barbas
Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis.
Chembiochem : a European journal of chemical biology 2010;11(15):2113-8.
2010: Katie J Doores; Zara Fulton; Vu Hong; Mitul K Patel; Christopher N Scanlan; Mark R Wormald; M G Finn; Dennis R Burton; Ian A Wilson; Benjamin G Davis
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17107-12.
2010: Michael Huber; Khoa M Le; Katie J Doores; Zara Fulton; Robyn L Stanfield; Ian A Wilson; Dennis R Burton
Very few substitutions in a germ line antibody are required to initiate significant domain exchange.
Journal of virology 2010;84(20):10700-7.
2010: Katie J Doores; Zara Fulton; Michael Huber; Ian A Wilson; Dennis R Burton
Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged.
Journal of virology 2010;84(20):10690-9.
2010: Katie J Doores; Dennis R Burton
Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16.
Journal of virology 2010;84(20):10510-21.
2010: Dennis R Burton; Robin A Weiss
AIDS/HIV. A boost for HIV vaccine design.
Science (New York, N.Y.) 2010;329(5993):770-3.
2010: Katie J Doores; Camille Bonomelli; David Harvey; Snezana Vasiljevic; Raymond A Dwek; Dennis R Burton; Max Crispin; Christopher N Scanlan
Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(31):13800-5.
2010: Robert Pejchal; Laura M Walker; Robyn L Stanfield; Sanjay K Phogat; Wayne C Koff; Pascal Poignard; Dennis R Burton; Ian A Wilson
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11483-8.
2010: Laura M Walker; Dennis R Burton
Rational antibody-based HIV-1 vaccine design: current approaches and future directions.
Current opinion in immunology 2010;22(3):358-66.
2010: Rena D Astronomo; Eiton Kaltgrad; Andrew K Udit; Sheng-Kai Wang; Katie J Doores; Cheng-Yuan Huang; Ralph Pantophlet; James C Paulson; Chi-Huey Wong; MG Finn; Dennis R Burton
Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds.
Chemistry & biology 2010;17(4):357-70.
2010: Rena D Astronomo; Dennis R Burton
Carbohydrate vaccines: developing sweet solutions to sticky situations?
Nature reviews. Drug discovery 2010;9(4):308-24.
2010: Ann J Hessell; Eva G Rakasz; David M Tehrani; Michael Huber; Kimberly L Weisgrau; Gary Landucci; Donald N Forthal; Wayne C Koff; Pascal Poignard; David Ian Watkins; Dennis R Burton
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L.
Journal of virology 2010;84(3):1302-13.
2010: Laura M Walker; Melissa D Simek; Frances Priddy; Johannes S Gach; Denise Wagner; Michael B Zwick; Sanjay K Phogat; Pascal Poignard; Dennis R Burton
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals.
PLoS pathogens 2010;6(8):e1001028.
2009: Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Science (New York, N.Y.) 2009;326(5956):1123-7.
2009: Jeffrey E Lee; Marnie L Fusco; Dafna M Abelson; Ann J Hessell; Dennis R Burton; Erica Ollmann Saphire
Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 11):1162-80.
2009: Laura M Walker; Sanjay K Phogat; Po-Ying Chan-Hui; Denise Wagner; Pham Phung; Julie L Goss; Terri Wrin; Melissa D Simek; Steven Fling; Jennifer L Mitcham; Jennifer K Lehrman; Frances H Priddy; Ole A Olsen; Steven M Frey; Phillip W Hammond; Stephen Kaminsky; Timothy Zamb; Matthew Moyle; Wayne C Koff; Pascal Poignard; Dennis R Burton
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.
Science (New York, N.Y.) 2009;326(5950):285-9.
2009: Robert Pejchal; Johannes Gach; Florence Brunel; Rosa M F Cardoso; Robyn L Stanfield; Philip E Dawson; Dennis R Burton; Michael B Zwick; Ian A Wilson
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.
Journal of virology 2009;83(17):8451-62.
2009: Ann J Hessell; Pascal Poignard; Meredith Hunter; Lars Hangartner; David M Tehrani; Wim K Bleeker; Paul W H I Parren; Preston A Marx; Dennis R Burton
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.
Nature medicine 2009;15(8):951-4.
2009: Laura M Walker; Diana R Bowley; Dennis R Burton
Efficient recovery of high-affinity antibodies from a single-chain Fab yeast display library.
Journal of molecular biology 2009;389(2):365-75.
2009: Ann J Hessell; Eva G Rakasz; Pascal Poignard; Lars Hangartner; Gary Landucci; Donald N Forthal; Wayne C Koff; David Ian Watkins; Dennis R Burton
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers.
PLoS pathogens 2009;5(5):e1000433.
2009: Lan Wu; Tongqing Zhou; Zhi-Yong Yang; Krisha Svehla; Sijy O'Dell; Mark K Louder; Ling Xu; John R Mascola; Dennis R Burton; James A Hoxie; Robert W Doms; Peter D Kwong; Gary Nabel
Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
Journal of virology 2009;83(10):5077-86.
2009: Dennis R Burton; Pascal Poignard
HIV: Immune memory downloaded.
Nature 2009;458(7238):584-5.
2009: Diana R Bowley; Teresa M Jones; Dennis R Burton; Richard A Lerner
Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1380-5.
2009: Ralph Pantophlet; Meng Wang; Rowena O Aguilar-Sino; Dennis R Burton
The human immunodeficiency virus type 1 envelope spike of primary viruses can suppress antibody access to variable regions.
Journal of virology 2009;83(4):1649-59.
2008: Ralph Pantophlet; Terri Wrin; Lisa A Cavacini; James E Robinson; Dennis R Burton
Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity.
Virology 2008;381(2):251-60.
2008: D Cameron Dunlop; Alexander Ulrich; Ben J Appelmelk; Dennis R Burton; Raymond A Dwek; Nicole Zitzmann; Christopher N Scanlan
Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
AIDS (London, England) 2008;22(16):2214-7.
2008: Stephanie Pollock; Raymond A Dwek; Dennis R Burton; Nicole Zitzmann
N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
AIDS (London, England) 2008;22(15):1961-9.
2008: Kyriacos C Nicolaou; T Robert Wu; David Sarlah; David M Shaw; Eric Rowcliffe; Dennis R Burton
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof.
Journal of the American Chemical Society 2008;130(33):11114-21.
2008: Anthony Fauci; Margaret I Johnston; Carl W Dieffenbach; Dennis R Burton; Scott M Hammer; James A Hoxie; Malcolm Martin; Julie Overbaugh; David Ian Watkins; Adel Mahmoud; Warner Greene
HIV vaccine research: the way forward.
Science (New York, N.Y.) 2008;321(5888):530-2.
2008: Josh D Nelson; Heather Kinkead; Florence Brunel; Dan Leaman; Richard Jensen; John M Louis; Toshiaki Maruyama; Carole A Bewley; Katherine Bowdish; G Marius Clore; Philip E Dawson; Shana Frederickson; Rose G Mage; Douglas D Richman; Dennis R Burton; Michael B Zwick
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
Virology 2008;377(1):170-83.
2008: Jeffrey E Lee; Marnie L Fusco; Ann J Hessell; Wendelien B Oswald; Dennis R Burton; Erica Ollmann Saphire
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature 2008;454(7201):177-82.
2008: Rena D Astronomo; Hing-Ken Lee; Christopher N Scanlan; Ralph Pantophlet; Cheng-Yuan Huang; Ian A Wilson; Ola Blixt; Raymond A Dwek; Chi-Huey Wong; Dennis R Burton
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
Journal of virology 2008;82(13):6359-68.
2008: Alfredo Menendez; Daniel A Calarese; Robyn L Stanfield; Keith C Chow; Chris N Scanlan; Renate Kunert; Herman Katinger; Dennis R Burton; Ian A Wilson; jamie scott
A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1380-92.
2008: Christopher N Scanlan; Dennis R Burton; Raymond A Dwek
Making autoantibodies safe.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4081-2.
2008: Sheng-Kai Wang; Po-Huang Liang; Rena D Astronomo; Tsui-Ling Sherry Hsu; Shie-Liang Hsieh; Dennis R Burton; Chi-Huey Wong
Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3690-5.
2008: Suganya Selvarajah; Bridget A Puffer; Fang-Hua Lee; Ping Zhu; Yuxing Li; Richard Wyatt; Kenneth H Roux; Robert W Doms; Dennis R Burton
Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140.
AIDS research and human retroviruses 2008;24(2):301-14.
2008: Gunilla B Karlsson Hedestam; Ron A M Fouchier; Sanjay Phogat; Dennis R Burton; Joseph Sodroski; Richard Wyatt
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Nature reviews. Microbiology 2008;6(2):143-55.
2008: Christian H Bell; Ralph Pantophlet; André Schiefner; Lisa A Cavacini; Robyn L Stanfield; Dennis R Burton; Ian A Wilson
Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.
Journal of molecular biology 2008;375(4):969-78.
2008: Mansun Law; Toshiaki Maruyama; Jamie Lewis; Erick Giang; Alexander W Tarr; Zania Stamataki; Pablo Gastaminza; Francis V Chisari; Ian M Jones; Robert I Fox; Jonathan K Ball; Jane A McKeating; Norman M Kneteman; Dennis R Burton
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.
Nature medicine 2008;14(1):25-7.
2007: Michael B Zwick; Dennis R Burton
HIV-1 neutralization: mechanisms and relevance to vaccine design.
Current HIV research 2007;5(6):608-24.
2007: Erin M Scherer; Michael B Zwick; Luc Teyton; Dennis R Burton
Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity.
AIDS (London, England) 2007;21(16):2131-9.
2007: Emma T Crooks; Penny L Moore; Michael Franti; Charmagne S Cayanan; Ping Zhu; Pengfei Jiang; Robbert P de Vries; Cheryl Wiley; Irina Zharkikh; Norbert Schülke; Kenneth H Roux; David C Montefiori; Dennis R Burton; James M Binley
A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.
Virology 2007;366(2):245-62.
2007: Dennis R Burton; Ian A Wilson
Immunology. Square-dancing antibodies.
Science (New York, N.Y.) 2007;317(5844):1507-8.
2007: Christopher N Scanlan; Gayle E Ritchie; Kavitha Baruah; Max Crispin; David Harvey; Bernhard Singer; Lothar Lucka; Mark R Wormald; Paul Wentworth; Nicole Zitzmann; Pauline M Rudd; Dennis R Burton; Raymond A Dwek
Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
Journal of molecular biology 2007;372(1):16-22.
2007: Ann J Hessell; Lars Hangartner; Meredith Hunter; Carin E G Havenith; Frank J Beurskens; Joost M Bakker; Caroline Lanigan; Gary Landucci; Donald N Forthal; Paul W H I Parren; Preston A Marx; Dennis R Burton
Fc receptor but not complement binding is important in antibody protection against HIV.
Nature 2007;449(7158):101-4.
2007: Nicholas J Mantis; Jana Palaia; Ann J Hessell; Simren Mehta; Zhiyi Zhu; Blaise Corthésy; Marian R Neutra; Dennis R Burton; Edward janoff
Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3144-52.
2007: John V Williams; Zhifeng Chen; Gabriella Cseke; David W Wright; Christopher Jay Keefer; Sharon J Tollefson; Ann J Hessell; Amy Podsiad; Bryan E Shepherd; Pietro Paolo Sanna; Dennis R Burton; James Crowe; R Anthony Williamson
A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo.
Journal of virology 2007;81(15):8315-24.
2007: Ralph Pantophlet; Rowena O Aguilar-Sino; Terri Wrin; Lisa A Cavacini; Dennis R Burton
Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis.
Virology 2007;364(2):441-53.
2007: Erica Ollmann Saphire; Marinieve Montero; Alfredo Menendez; Nienke E van Houten; Melita B Irving; Ralph Pantophlet; Michael B Zwick; Paul W H I Parren; Dennis R Burton; jamie scott; Ian A Wilson
Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Journal of molecular biology 2007;369(3):696-709.
2007: Amandeep K Dhillon; Helen Donners; Ralph Pantophlet; Welkin E Johnson; Julie M Decker; George M Shaw; Fang-Hua Lee; Douglas D Richman; Robert W Doms; Guido Vanham; Dennis R Burton
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors.
Journal of virology 2007;81(12):6548-62.
2007: Josh D Nelson; Florence Brunel; Richard Jensen; Emma T Crooks; Rosa M F Cardoso; Meng Wang; Ann J Hessell; Ian A Wilson; James M Binley; Philip E Dawson; Dennis R Burton; Michael B Zwick
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
Journal of virology 2007;81(8):4033-43.
2007: Mansun Law; Rosa M F Cardoso; Ian A Wilson; Dennis R Burton
Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
Journal of virology 2007;81(8):4272-85.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2007: Rosa M F Cardoso; Florence Brunel; Sharon Ferguson; Michael B Zwick; Dennis R Burton; Philip E Dawson; Ian A Wilson
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
Journal of molecular biology 2007;365(5):1533-44.
2007: D R Bowley; Aran F Labrijn; Michael B Zwick; Dennis R Burton
Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.
Protein engineering, design & selection : PEDS 2007;20(2):81-90.
2007: Wendelien B Oswald; Thomas W Geisbert; Kelly J Davis; Joan B Geisbert; Nancy J Sullivan; Peter B Jahrling; Paul W H I Parren; Dennis R Burton
Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.
PLoS pathogens 2007;3(1):e9.
2006: Estelle Leclerc; Hana Serban; Stanley B Prusiner; Dennis R Burton; R Anthony Williamson
Copper induces conformational changes in the N-terminal part of cell-surface PrPC.
Archives of virology 2006;151(11):2103-9.
2006: Béatrice Luginbühl; Zoltan F Kanyo; R Mark Jones; Robert J Fletterick; Stanley B Prusiner; Fred Cohen; R Anthony Williamson; Dennis R Burton; Andreas Plückthun
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Journal of molecular biology 2006;363(1):75-97.
2006: Dennis R Burton; Raymond A Dwek
Immunology. Sugar determines antibody activity.
Science (New York, N.Y.) 2006;313(5787):627-8.
2006: Eloisa Yuste; Hannah B Sanford; Jill Carmody; Jacqueline Bixby; Susan Little; Michael B Zwick; Tom Greenough; Dennis R Burton; Douglas D Richman; Ronald C Desrosiers; Welkin E Johnson
Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma.
Journal of virology 2006;80(6):3030-41.
2006: Penny L Moore; Emma T Crooks; Lauren Porter; Ping Zhu; Charmagne S Cayanan; Henry Grise; Paul corcoran; Michael B Zwick; Michael Franti; Lynn Morris; Kenneth H Roux; Dennis R Burton; James M Binley
Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.
Journal of virology 2006;80(5):2515-28.
2006: Florence Brunel; Michael B Zwick; Rosa M F Cardoso; Josh D Nelson; Ian A Wilson; Dennis R Burton; Philip E Dawson
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
Journal of virology 2006;80(4):1680-7.
2006: James M Binley; Stacie Ngo-Abdalla; Penny Moore; Michael D Bobardt; Udayan Chatterji; Philippe A Gallay; Dennis R Burton; Ian A Wilson; John H Elder; Aymeric de Parseval
Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120.
Retrovirology 2006;3():39.
2006: Ralph Pantophlet; Dennis R Burton
GP120: target for neutralizing HIV-1 antibodies.
Annual review of immunology 2006;24():739-69.
2006: Sara Venturini; Gina Allicotti; Yindong Zhao; Richard Simon; Dennis R Burton; Clemencia Pinilla; Pascal Poignard
Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone.
European journal of immunology 2006;36(1):27-36.
2005: Dennis R Burton; Robyn L Stanfield; Ian A Wilson
Antibody vs. HIV in a clash of evolutionary titans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):14943-8.
2005: Suganya Selvarajah; Bridget Puffer; Ralph Pantophlet; Mansun Law; Robert W Doms; Dennis R Burton
Comparing antigenicity and immunogenicity of engineered gp120.
Journal of virology 2005;79(19):12148-63.
2005: Daniel A Calarese; Hing-Ken Lee; Cheng-Yuan Huang; Michael D Best; Rena D Astronomo; Robyn L Stanfield; Hermann Katinger; Dennis R Burton; Chi-Huey Wong; Ian A Wilson
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13372-7.
2005: Brett D Lindenbach; Matthew J Evans; Andrew J Syder; Benno Wölk; Timothy L Tellinghuisen; Christopher C Liu; Toshiaki Maruyama; Richard O Hynes; Dennis R Burton; Jane A McKeating; Charles M Rice
Complete replication of hepatitis C virus in cell culture.
Science (New York, N.Y.) 2005;309(5734):623-6.
2005: Jin Zhong; Pablo Gastaminza; Guofeng Cheng; Sharookh B Kapadia; Takanobu Kato; Dennis R Burton; Stefan F Wieland; Susan L Uprichard; Takaji Wakita; Francis V Chisari
Robust hepatitis C virus infection in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9294-9.
2005: Klaus Koefoed; Lauge Farnaes; Meng Wang; Arne Svejgaard; Dennis R Burton; Henrik J Ditzel
Molecular characterization of the circulating anti-HIV-1 gp120-specific B cell repertoire using antibody phage display libraries generated from pre-selected HIV-1 gp120 binding PBLs.
Journal of immunological methods 2005;297(1-2):187-201.
2005: Rosa M F Cardoso; Michael B Zwick; Robyn L Stanfield; Renate Kunert; James M Binley; Hermann Katinger; Dennis R Burton; Ian A Wilson
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.
Immunity 2005;22(2):163-73.
2005: Michael B Zwick; Richard Jensen; Sarah Church; Meng Wang; Gabriela Stiegler; Renate Kunert; Hermann Katinger; Dennis R Burton
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.
Journal of virology 2005;79(2):1252-61.
2004: Ola Blixt; Steven R Head; Tony Mondala; Christopher N Scanlan; Margaret E Huflejt; Richard Alvarez; Marian C. Bryan; Fabio Fazio; Daniel A Calarese; James Stevens; Nahid Razi; David J Stevens; John J Skehel; Irma Van Die; Dennis R Burton; Ian A Wilson; Richard D Cummings; Nicolai Bovin; Chi-Huey Wong; James C Paulson
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17033-8.
2004: James M Binley; Terri Wrin; Bette Korber; Michael B Zwick; Meng Wang; Colombe Chappey; Gabriela Stiegler; Renate Kunert; Susan Zolla-Pazner; Hermann Katinger; Christos J Petropoulos; Dennis R Burton
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies.
Journal of virology 2004;78(23):13232-52.
2004: Ralph Pantophlet; Ian A Wilson; Dennis R Burton
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12.
Protein engineering, design & selection : PEDS 2004;17(10):749-58.
2004: Mei-Yun Zhang; Xiaodong Xiao; Igor A Sidorov; Vidita Choudhry; Fatim Cham; Peng Fei Zhang; Peter Bouma; Michael B Zwick; Anil Choudhary; David C Montefiori; Christopher C Broder; Dennis R Burton; Gerald V Quinnan; Dimiter S Dimitrov
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Journal of virology 2004;78(17):9233-42.
2004: John P Moore; Dennis R Burton
Urgently needed: a filter for the HIV-1 vaccine pipeline.
Nature medicine 2004;10(8):769-71.
2004: Gianluca Moroncini; Nnennaya Kanu; Laura Solforosi; Gil Abalos; Glenn C Telling; Mark W Head; James Ironside; Jeremy P Brockes; Dennis R Burton; R Anthony Williamson
Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10404-9.
2004: Toshiaki Maruyama; Ichiro Saito; Yoshio Hayashi; Elizabeth Kompfner; Robert I Fox; Dennis R Burton; Henrik J Ditzel
Molecular analysis of the human autoantibody response to alpha-fodrin in Sjögren's syndrome reveals novel apoptosis-induced specificity.
The American journal of pathology 2004;165(1):53-61.
2004: Michael B Zwick; H Kiyomi Komori; Robyn L Stanfield; Sarah Church; Meng Wang; Paul W H I Parren; Renate Kunert; Hermann Katinger; Ian A Wilson; Dennis R Burton
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.
Journal of virology 2004;78(6):3155-61.
2004: Dennis R Burton; Ronald C Desrosiers; Robert W Doms; Wayne C Koff; Peter D Kwong; John P Moore; Gary Nabel; Joseph Sodroski; Ian A Wilson; Richard Wyatt
HIV vaccine design and the neutralizing antibody problem.
Nature immunology 2004;5(3):233-6.
2004: Alyssa C Biorn; Simon Cocklin; Navid Madani; Zhihai Si; Tijana Ivanovic; James Samanen; Donald Van Ryk; Ralph Pantophlet; Dennis R Burton; Ernesto Freire; Joseph Sodroski; Irwin Chaiken
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.
Biochemistry 2004;43(7):1928-38.
2004: Ramalakshmi Darbha; Sanjay Phogat; Aran F Labrijn; Yuuei Shu; Yijun Gu; Michelle Andrykovitch; Mei-Yun Zhang; Ralph Pantophlet; Loic MARTIN; Claudio Vita; Dennis R Burton; Dimiter S Dimitrov; Xinhua Ji
Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope.
Biochemistry 2004;43(6):1410-7.
2004: Hing-Ken Lee; Christopher N Scanlan; Cheng-Yuan Huang; Aileen Y Chang; Daniel A Calarese; Raymond A Dwek; Pauline M Rudd; Dennis R Burton; Ian A Wilson; Chi-Huey Wong
Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody.
Angewandte Chemie (International ed. in English) 2004;43(8):1000-3.
2004: Michael B Zwick; Erica Ollmann Saphire; Dennis R Burton
gp41: HIV's shy protein.
Nature medicine 2004;10(2):133-4.
2003: Ralph Pantophlet; Dennis R Burton
Immunofocusing: antigen engineering to promote the induction of HIV-neutralizing antibodies.
Trends in molecular medicine 2003;9(11):468-73.
2003: Aran F Labrijn; Pascal Poignard; Aarti Raja; Michael B Zwick; Karla Delgado; Michael Franti; James M Binley; Veronique Vivona; Christoph Grundner; Chih-Chin Huang; Miro Venturi; Christos J Petropoulos; Terri Wrin; Dimiter S Dimitrov; James Robinson; Peter D Kwong; Richard Wyatt; Joseph Sodroski; Dennis R Burton
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Journal of virology 2003;77(19):10557-65.
2003: John R Mascola; Mark G Lewis; Thomas C VanCott; Gabriela Stiegler; Hermann Katinger; Michael S Seaman; Kristin Beaudry; Dan H Barouch; Birgit Korioth-Schmitz; Georgia R Krivulka; Anna Sambor; Brent Welcher; Daniel C Douek; David C Montefiori; John W Shiver; Pascal Poignard; Dennis R Burton; Norman L Letvin
Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies.
Journal of virology 2003;77(19):10348-56.
2003: Welkin E Johnson; Hannah B Sanford; Linda Schwall; Dennis R Burton; Paul W H I Parren; James E Robinson; Ronald C Desrosiers
Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities.
Journal of virology 2003;77(18):9993-10003.
2003: Peter J Peters; Alexander Mironov; David Peretz; Elly van Donselaar; Estelle Leclerc; Susanne Erpel; Stephen J DeArmond; Dennis R Burton; R Anthony Williamson; Martin Vey; Stanley B Prusiner
Trafficking of prion proteins through a caveolae-mediated endosomal pathway.
The Journal of cell biology 2003;162(4):703-17.
2003: Hyeryun Choe; Wenhui Li; Paulette L Wright; Natalya Vasilieva; Miro Venturi; Chih-Chin Huang; Christoph Grundner; Tatyana Dorfman; Michael B Zwick; Liping Wang; Eric S Rosenberg; Peter D Kwong; Dennis R Burton; James E Robinson; Joseph Sodroski; Michael Farzan
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.
Cell 2003;114(2):161-70.
2003: Daniel A Calarese; Christopher N Scanlan; Michael B Zwick; Songpon Deechongkit; Yusuke Mimura; Renate Kunert; Ping Zhu; Mark R Wormald; Robyn L Stanfield; Kenneth H Roux; Jeffery W Kelly; Pauline M Rudd; Raymond A Dwek; Hermann Katinger; Dennis R Burton; Ian A Wilson
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science (New York, N.Y.) 2003;300(5628):2065-71.
2003: Michael B Zwick; Robert Kelleher; Richard Jensen; Aran F Labrijn; Meng Wang; Gerald V Quinnan; Paul W H I Parren; Dennis R Burton
A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.
Journal of virology 2003;77(12):6965-78.
2003: Ralph Pantophlet; Ian A Wilson; Dennis R Burton
Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.
Journal of virology 2003;77(10):5889-901.
2003: Michael B Zwick; Paul W H I Parren; Erica Ollmann Saphire; Sarah Church; Meng Wang; jamie scott; Philip E Dawson; Ian A Wilson; Dennis R Burton
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.
Journal of virology 2003;77(10):5863-76.
2003: James M Binley; Charmagne S Cayanan; Cheryl Wiley; Norbert Schülke; William C Olson; Dennis R Burton
Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions.
Journal of virology 2003;77(10):5678-84.
2003: Estelle Leclerc; David Peretz; Haydn Ball; Laura Solforosi; Giuseppe Legname; Jiri G Safar; Ana Serban; Stanley B Prusiner; Dennis R Burton; R Anthony Williamson
Conformation of PrP(C) on the cell surface as probed by antibodies.
Journal of molecular biology 2003;326(2):475-83.
2003: Christopher N Scanlan; Ralph Pantophlet; Mark R Wormald; Erica Ollmann Saphire; Daniel A Calarese; Robyn L Stanfield; Ian A Wilson; Hermann Katinger; Raymond A Dwek; Dennis R Burton; Pauline M Rudd
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
Advances in experimental medicine and biology 2003;535():205-18.
2003: Erica Ollmann Saphire; Robyn L Stanfield; Max Crispin; Garrett Morris; Michael B Zwick; Ralph Pantophlet; Paul W H I Parren; Pauline M Rudd; Raymond A Dwek; Dennis R Burton; Ian A Wilson
Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
Advances in experimental medicine and biology 2003;535():55-66.
2003: Carolina Herrera; Catherine Spenlehauer; Michael S Fung; Dennis R Burton; Simon Beddows; John P Moore
Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same site.
Journal of virology 2003;77(2):1084-91.
2003: Ralph Pantophlet; Erica Ollmann Saphire; Pascal Poignard; Paul W H I Parren; Ian A Wilson; Dennis R Burton
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.
Journal of virology 2003;77(1):642-58.
2003: Pascal Poignard; Maxime Moulard; Edwin Golez; Veronique Vivona; Michael Franti; Sara Venturini; Meng Wang; Paul W H I Parren; Dennis R Burton
Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies.
Journal of virology 2003;77(1):353-65.
2002: Peter D Kwong; Michael Doyle; David J Casper; Claudia Cicala; Stephanie A Leavitt; Shahzad Majeed; Tavis D Steenbeke; Miro Venturi; Irwin Chaiken; Michael Fung; Hermann Katinger; Paul W I H Parren; James Robinson; Donald Van Ryk; Liping Wang; Dennis R Burton; Ernesto Freire; Richard Wyatt; Joseph Sodroski; Wayne A Hendrickson; James Arthos
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature 2002;420(6916):678-82.
2002: Jiri G Safar; Michael Scott; Jeff Monaghan; Camille Deering; Svetlana Didorenko; Julie Vergara; Haydn Ball; Giuseppe Legname; Estelle Leclerc; Laura Solforosi; Hana Serban; Darlene Groth; Dennis R Burton; Stanley B Prusiner; R Anthony Williamson
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.
Nature biotechnology 2002;20(11):1147-50.
2002: Felix Meissner; Toshiaki Maruyama; Marco Frentsch; Ann J Hessell; Luis L Rodriguez; Thomas W Geisbert; Peter B Jahrling; Dennis R Burton; Paul W H I Parren
Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay.
Virology 2002;300(2):236-43.
2002: Dennis R Burton
Antibodies, viruses and vaccines.
Nature reviews. Immunology 2002;2(9):706-13.
2002: Christopher N Scanlan; Ralph Pantophlet; Mark R Wormald; Erica Ollmann Saphire; Robyn L Stanfield; Ian A Wilson; Hermann Katinger; Raymond A Dwek; Pauline M Rudd; Dennis R Burton
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
Journal of virology 2002;76(14):7306-21.
2002: Sara Venturini; Donald E Mosier; Dennis R Burton; Pascal Poignard
Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization.
Journal of virology 2002;76(14):6987-99.
2002: David Peretz; R Anthony Williamson; Giuseppe Legname; Yoichi Matsunaga; Julie Vergara; Dennis R Burton; Stephen J DeArmond; Stanley B Prusiner; Michael R Scott
A change in the conformation of prions accompanies the emergence of a new prion strain.
Neuron 2002;34(6):921-32.
2002: Paul W H I Parren; Thomas W Geisbert; Toshiaki Maruyama; Peter B Jahrling; Dennis R Burton
Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody.
Journal of virology 2002;76(12):6408-12.
2002: Erica Ollmann Saphire; Robyn L Stanfield; Max Crispin; Paul W H I Parren; Pauline M Rudd; Raymond A Dwek; Dennis R Burton; Ian A Wilson
Contrasting IgG structures reveal extreme asymmetry and flexibility.
Journal of molecular biology 2002;319(1):9-18.
2002: Maxime Moulard; Sanjay Phogat; Yuuei Shu; Aran F Labrijn; Xiaodong Xiao; James M Binley; Mei-Yun Zhang; Igor A Sidorov; Christopher C Broder; James Robinson; Paul W H I Parren; Dennis R Burton; Dimiter S Dimitrov
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6913-8.
2002: James M Binley; Rogier W Sanders; Aditi Master; Charmagne S Cayanan; Cheryl Wiley; Linnea Schiffner; Bruce Travis; Shawn E Kuhmann; Dennis R Burton; Shiu-Lok Hu; William C Olson; John P Moore
Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.
Journal of virology 2002;76(6):2606-16.
2001: Michael B Zwick; Meng Wang; Pascal Poignard; Gabriela Stiegler; Hermann Katinger; Dennis R Burton; Paul W H I Parren
Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.
Journal of virology 2001;75(24):12198-208.
2001: Michael B Zwick; Aran F Labrijn; Meng Wang; C Spenlehauer; Erica Ollmann Saphire; James M Binley; John P Moore; Gabriela Stiegler; Hermann Katinger; Dennis R Burton; Paul W H I Parren
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.
Journal of virology 2001;75(22):10892-905.
2001: Paul W H I Parren; Preston A Marx; Ann J Hessell; Amara Luckay; Janet M Harouse; Cecilia Cheng-Mayer; John P Moore; Dennis R Burton
Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro.
Journal of virology 2001;75(17):8340-7.
2001: David Peretz; R Anthony Williamson; Kiyotoshi Kaneko; Julie Vergara; Estelle Leclerc; Gerold Schmitt-Ulms; IR Mehlhorn; Giuseppe Legname; M R Wormald; P M Rudd; R A Dwek; Dennis R Burton; Stanley B Prusiner
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity.
Nature 2001;412(6848):739-43.
2001: Erica Ollmann Saphire; Paul W H I Parren; Ralph Pantophlet; Michael B Zwick; G M Morris; Pauline M Rudd; Raymond A Dwek; Robyn L Stanfield; Dennis R Burton; Ian A Wilson
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science (New York, N.Y.) 2001;293(5532):1155-9.
2001: Monica Schaller; Dennis R Burton; Henrik J Ditzel
Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease.
Nature immunology 2001;2(8):746-53.
2001: Michael B Zwick; LL Bonnycastle; Alfredo Menendez; M B Irving; C F Barbas; Paul W H I Parren; Dennis R Burton; jamie scott
Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12.
Journal of virology 2001;75(14):6692-9.
2001: John P Moore; P W Parren; Dennis R Burton
Genetic subtypes, humoral immunity, and human immunodeficiency virus type 1 vaccine development.
Journal of virology 2001;75(13):5721-9.
2001: Estelle Leclerc; David Peretz; Haydn Ball; H Sakurai; Giuseppe Legname; Ana Serban; Stanley B Prusiner; Dennis R Burton; R Anthony Williamson
Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form.
The EMBO journal 2001;20(7):1547-54.
2001: David Peretz; Michael R Scott; Darlene Groth; R Anthony Williamson; Dennis R Burton; Fred Cohen; Stanley B Prusiner
Strain-specified relative conformational stability of the scrapie prion protein.
Protein science : a publication of the Protein Society 2001;10(4):854-63.
2001: R Anthony Williamson; Mark P Burgoon; Gregory P Owens; O Ghausi; Estelle Leclerc; L Firme; S Carlson; John R Corboy; Paul W H I Parren; Pietro Paolo Sanna; Donald H Gilden; Dennis R Burton
Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1793-8.
2001: Dennis R Burton; Erica Ollmann Saphire; Paul W H I Parren
A model for neutralization of viruses based on antibody coating of the virion surface.
Current topics in microbiology and immunology 2001;260():109-43.
2001: Paul W H I Parren; Dennis R Burton
The antiviral activity of antibodies in vitro and in vivo.
Advances in immunology 2001;77():195-262.
2001: Pascal Poignard; Erica Ollmann Saphire; Paul W H I Parren; Dennis R Burton
gp120: Biologic aspects of structural features.
Annual review of immunology 2001;19():253-74.
2001: Donald H Gilden; Mark P Burgoon; Bette K Kleinschmidt-DeMasters; R Anthony Williamson; O Ghausi; Dennis R Burton; Gregory P Owens
Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis.
Archives of neurology 2001;58(1):43-8.
2001: Erica Ollmann Saphire; Paul W H I Parren; C F Barbas; Dennis R Burton; Ian A Wilson
Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):168-71.
2000: P P Sanna; Dennis R Burton
Role of antibodies in controlling viral disease: lessons from experiments of nature and gene knockouts.
Journal of virology 2000;74(21):9813-7.
2000: Henrik J Ditzel; Y Masaki; H Nielsen; Lauge Farnaes; Dennis R Burton
Cloning and expression of a novel human antibody-antigen pair associated with Felty's syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9234-9.
2000: Lucy Dorrell; Ann J Hessell; Meng Wang; Hilton Whittle; Saihou Sabally; Sarah Rowland-Jones; Dennis R Burton; Paul W H I Parren
Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia.
AIDS (London, England) 2000;14(9):1117-22.
2000: Dennis R Burton; R Anthony Williamson; Paul W H I Parren
Antibody and virus: binding and neutralization.
Virology 2000;270(1):1-3.
2000: Dennis R Burton; Paul W H I Parren
Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?
Nature medicine 2000;6(2):123-5.
2000: Gregory P Owens; R Anthony Williamson; Mark P Burgoon; O Ghausi; Dennis R Burton; Donald H Gilden
Cloning the antibody response in humans with chronic inflammatory disease: immunopanning of subacute sclerosing panencephalitis (SSPE) brain sections with antibody phage libraries prepared from SSPE brain enriches for antibody recognizing measles virus antigens in situ.
Journal of virology 2000;74(3):1533-7.
2000: H Wang; M N Griffiths; Dennis R Burton; Peter Ghazal
Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):847-52.
2000: Paul W H I Parren; Pascal Poignard; Henrik J Ditzel; R Anthony Williamson; Dennis R Burton
Antibodies in human infectious disease.
Immunologic research 2000;21(2-3):265-78.
1999: Zoltan F Kanyo; K M Pan; R Anthony Williamson; Dennis R Burton; Stanley B Prusiner; Robert J Fletterick; Fred Cohen
Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
Journal of molecular biology 1999;293(4):855-63.
1999: Toshiaki Maruyama; Luis L Rodriguez; Peter B Jahrling; A Sanchez; A S Khan; S T Nichol; Clarence Peters; Paul W H I Parren; Dennis R Burton
Ebola virus can be effectively neutralized by antibody produced in natural human infection.
Journal of virology 1999;73(7):6024-30.
1999: Pascal Poignard; RE Sabbe; Gastón R Picchio; Meng Wang; Rick gulizia; Hermann Katinger; Paul W H I Parren; Donald E Mosier; Dennis R Burton
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.
Immunity 1999;10(4):431-8.
1999: H Sakurai; R Anthony Williamson; James Crowe; J A Beeler; Pascal Poignard; RB Bastidas; Robert M Chanock; Dennis R Burton
Human antibody responses to mature and immature forms of viral envelope in respiratory syncytial virus infection: significance for subunit vaccines.
Journal of virology 1999;73(4):2956-62.
1999: PP Sanna; M E Samson; J S Moon; R Rozenshteyn; A De Logu; R Anthony Williamson; Dennis R Burton
pFab-CMV, a single vector system for the rapid conversion of recombinant Fabs into whole IgG1 antibodies.
Immunotechnology : an international journal of immunological engineering 1999;4(3-4):185-8.
1999: Mark P Burgoon; R Anthony Williamson; Gregory P Owens; O Ghausi; RB Bastidas; Dennis R Burton; Donald H Gilden
Cloning the antibody response in humans with inflammatory CNS disease: isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain.
Journal of neuroimmunology 1999;94(1-2):204-11.
1999: Toshiaki Maruyama; Paul W H I Parren; A Sanchez; I Rensink; Luis L Rodriguez; A S Khan; Clarence Peters; Dennis R Burton
Recombinant human monoclonal antibodies to Ebola virus.
The Journal of infectious diseases 1999;179 Suppl 1():S235-9.
1999: Paul W H I Parren; John P Moore; Dennis R Burton; Quentin J Sattentau
The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity.
AIDS (London, England) 1999;13 Suppl A():S137-62.
1998: James Crowe; Cai-Yen Firestone; Roberta L Crim; J A Beeler; Kathleen L Coelingh; C F Barbas; Dennis R Burton; Robert M Chanock; Brian Murphy
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.
Virology 1998;252(2):373-5.
1998: Paul W H I Parren; Meng Wang; Alexandra Trkola; James M Binley; M Purtscher; Hermann Katinger; John P Moore; Dennis R Burton
Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1.
Journal of virology 1998;72(12):10270-4.
1998: A De Logu; R Anthony Williamson; R Rozenshteyn; F Ramiro-Ibañez; C D Simpson; Dennis R Burton; PP Sanna
Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential.
Journal of clinical microbiology 1998;36(11):3198-204.
1998: R Anthony Williamson; David Peretz; Clemencia Pinilla; Haydn Ball; RB Bastidas; R Rozenshteyn; R A Houghten; Stanley B Prusiner; Dennis R Burton
Mapping the prion protein using recombinant antibodies.
Journal of virology 1998;72(11):9413-8.
1998: YF Graus; Marc H De Baets; Dennis R Burton
Antiacetylcholine receptor Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.
Annals of the New York Academy of Sciences 1998;841():414-7.
1998: Dennis R Burton; John P Moore
Why do we not have an HIV vaccine and how can we make one? .
Nature medicine 1998;4(5 Suppl):495-8.
1998: Paul W H I Parren; I Mondor; Denise Naniche; Henrik J Ditzel; Per Johan Klasse; Dennis R Burton; Quentin J Sattentau
Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity.
Journal of virology 1998;72(5):3512-9.
1998: Henrik J Ditzel; M M Rosenkilde; Peter Garred; M Wang; Klaus Koefoed; C Pedersen; Dennis R Burton; T W Schwartz
The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5241-5.
1998: J F LeBlanc; K E McLane; Paul W H I Parren; Dennis R Burton; Peter Ghazal
Recognition properties of a sequence-specific DNA binding antibody.
Biochemistry 1998;37(17):6015-22.
1998: E M Salonen; Paul W H I Parren; YF Graus; Ake Lundkvist; P Fisicaro; Olli Vapalahti; Hannimari Kallio-Kokko; Antti Vaheri; Dennis R Burton
Human recombinant Puumala virus antibodies: cross-reaction with other hantaviruses and use in diagnostics.
The Journal of general virology 1998;79 ( Pt 4)():659-65.
1998: YF Graus; Jan J Verschuuren; A Degenhardt; Peter J C van Breda Vriesman; Marc H De Baets; Jerome B Posner; Dennis R Burton; Josep Dalmau
Selection of recombinant anti-HuD Fab fragments from a phage display antibody library of a lung cancer patient with paraneoplastic encephalomyelitis.
Journal of neuroimmunology 1998;82(2):200-9.
1998: J Glamann; Dennis R Burton; Paul W H I Parren; Henrik J Ditzel; K A Kent; C Arnold; David Montefiori; Vanessa M Hirsch
Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque.
Journal of virology 1998;72(1):585-92.
1997: Marie-Claire E Gauduin; Paul W H I Parren; R Weir; C F Barbas; Dennis R Burton; RA Koup
Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1.
Nature medicine 1997;3(12):1389-93.
1997: David Peretz; R Anthony Williamson; Yoichi Matsunaga; Hana Serban; Clemencia Pinilla; RB Bastidas; R Rozenshteyn; Tom L James; R A Houghten; Fred Cohen; Stanley B Prusiner; Dennis R Burton
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
Journal of molecular biology 1997;273(3):614-22.
1997: S Ugolini; I Mondor; Paul W H I Parren; Dennis R Burton; S A Tilley; Per Johan Klasse; Quentin J Sattentau
Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization.
The Journal of experimental medicine 1997;186(8):1287-98.
1997: Dennis R Burton
A vaccine for HIV type 1: the antibody perspective.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10018-23.
1997: H Mo; Leonidas Stamatatos; JE Ip; C F Barbas; Paul W H I Parren; Dennis R Burton; John P Moore; David D Ho
Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off.
Journal of virology 1997;71(9):6869-74.
1997: R Anthony Williamson; Tiziana Lazzarotto; PP Sanna; RB Bastidas; B Dalla Casa; G Campisi; R Burioni; M P Landini; Dennis R Burton
Use of recombinant human antibody fragments for detection of cytomegalovirus antigenemia.
Journal of clinical microbiology 1997;35(8):2047-50.
1997: Paul W H I Parren; Marie-Claire E Gauduin; RA Koup; Pascal Poignard; Quentin J Sattentau; P Fisicaro; Dennis R Burton
Erratum to "Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design".
Immunology letters 1997;58(2):125-32.
1997: Paul W H I Parren; Marie-Claire E Gauduin; RA Koup; Pascal Poignard; P Fisicaro; Dennis R Burton; Quentin J Sattentau
Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design.
Immunology letters 1997;57(1-3):105-12.
1997: YF Graus; Marc H De Baets; Peter J C van Breda Vriesman; Dennis R Burton
Anti-acetylcholine receptor Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.
Immunology letters 1997;57(1-3):59-62.
1997: Henrik J Ditzel; Paul W H I Parren; James M Binley; Joseph Sodroski; John P Moore; Carlos F Barbas; Dennis R Burton
Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries.
Journal of molecular biology 1997;267(3):684-95.
1997: YF Graus; Marc H De Baets; Paul W H I Parren; Sonia Berrih-Aknin; J Wokke; Peter J C van Breda Vriesman; Dennis R Burton
Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1919-29.
1997: Dennis R Burton; D C Montefiori
The antibody response in HIV-1 infection.
AIDS (London, England) 1997;11 Suppl A():S87-98.
1996: Paul W H I Parren; P Fisicaro; A F Labrijn; James M Binley; W P Yang; Henrik J Ditzel; Carlos F Barbas; Dennis R Burton
In vitro antigen challenge of human antibody libraries for vaccine evaluation: the human immunodeficiency virus type 1 envelope.
Journal of virology 1996;70(12):9046-50.
1996: Larry Zeitlin; Kevin J Whaley; PP Sanna; Thomas R Moench; RB Bastidas; A De Logu; R Anthony Williamson; Dennis R Burton; Richard A Cone
Topically applied human recombinant monoclonal IgG1 antibody and its Fab and F(ab')2 fragments protect mice from vaginal transmission of HSV-2.
Virology 1996;225(1):213-5.
1996: Henrik J Ditzel; K Itoh; Dennis R Burton
Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):739-49.
1996: R Anthony Williamson; David Peretz; N Smorodinsky; RB Bastidas; Hana Serban; IR Mehlhorn; Stephen J DeArmond; Stanley B Prusiner; Dennis R Burton
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7279-82.
1996: James M Binley; Henrik J Ditzel; Carlos F Barbas; N Sullivan; Joseph Sodroski; Paul W H I Parren; Dennis R Burton
Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding.
AIDS research and human retroviruses 1996;12(10):911-24.
1996: Carlos F Barbas; Dennis R Burton
Selection and evolution of high-affinity human anti-viral antibodies.
Trends in biotechnology 1996;14(7):230-4.
1996: Marie-Claire E Gauduin; G P Allaway; Paul J Maddon; Carlos F Barbas; Dennis R Burton; RA Koup
Effective ex vivo neutralization of human immunodeficiency virus type 1 in plasma by recombinant immunoglobulin molecules.
Journal of virology 1996;70(4):2586-92.
1996: PP Sanna; A De Logu; R Anthony Williamson; Y L Hom; S E Straus; F E Bloom; Dennis R Burton
Protection of nude mice by passive immunization with a type-common human recombinant monoclonal antibody against HSV.
Virology 1996;215(1):101-6.
1995: W P Yang; K Green; S Pinz-Sweeney; A T Briones; Dennis R Burton; Carlos F Barbas
CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range.
Journal of molecular biology 1995;254(3):392-403.
1995: PP Sanna; A De Logu; R Anthony Williamson; M E Samson; D C Altieri; F E Bloom; Dennis R Burton
Rapid assay of phage-derived recombinant human fabs as bispecific antibodies.
Bio/technology (Nature Publishing Company) 1995;13(11):1221-4.
1995: Alexandra Trkola; A B Pomales; H Yuan; B Korber; Paul J Maddon; G P Allaway; Hermann Katinger; Carlos F Barbas; Dennis R Burton; David D Ho
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
Journal of virology 1995;69(11):6609-17.
1995: Gregg J Silverman; S Barbas; P Roben; Dennis R Burton
Repertoire cloning of human lupus autoantibodies.
Annals of the New York Academy of Sciences 1995;764():565-6.
1995: Dennis R Burton
Phage display.
Immunotechnology : an international journal of immunological engineering 1995;1(2):87-94.
1995: PP Sanna; R Anthony Williamson; A De Logu; F E Bloom; Dennis R Burton
Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6439-43.
1995: Paul W H I Parren; Henrik J Ditzel; Rick gulizia; James M Binley; Carlos F Barbas; Dennis R Burton; Donald E Mosier
Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site.
AIDS (London, England) 1995;9(6):F1-6.
1995: K E McLane; Dennis R Burton; Peter Ghazal
Transplantation of a 17-amino acid alpha-helical DNA-binding domain into an antibody molecule confers sequence-dependent DNA recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5214-8.
1995: I Moreno de Alborán; C Martínéz-alonso; Carlos F Barbas; Dennis R Burton; Henrik J Ditzel
Human monoclonal Fab fragments specific for viral antigens from combinatorial IgA libraries.
Immunotechnology : an international journal of immunological engineering 1995;1(1):21-8.
1995: S M Barbas; Henrik J Ditzel; E M Salonen; W P Yang; Gregg J Silverman; Dennis R Burton
Human autoantibody recognition of DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2529-33.
1995: Henrik J Ditzel; James M Binley; J P Moore; Joseph Sodroski; N Sullivan; L S Sawyer; R M Hendry; W P Yang; Carlos F Barbas; Dennis R Burton
Neutralizing recombinant human antibodies to a conformational V2- and CD4-binding site-sensitive epitope of HIV-1 gp120 isolated by using an epitope-masking procedure.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):893-906.
1995: J P Moore; Y Cao; L Qing; Quentin J Sattentau; J Pyati; R Koduri; J Robinson; Carlos F Barbas; Dennis R Burton; David D Ho
Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
Journal of virology 1995;69(1):101-9.
1994: Dennis R Burton; Carlos F Barbas
Human monoclonal antibodies: recent achievements.
Hospital practice (Office ed.) 1994;29(11):111, 114-6, 119 passim.
1994: Dennis R Burton; J Pyati; R Koduri; S J Sharp; george thornton; Paul W H I Parren; L S Sawyer; R M Hendry; N Dunlop; P L Nara
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.
Science (New York, N.Y.) 1994;266(5187):1024-7.
1994: P Roben; J P Moore; M Thali; Joseph Sodroski; Carlos F Barbas; Dennis R Burton
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
Journal of virology 1994;68(8):4821-8.
1994: Carlos F Barbas; D Hu; N Dunlop; L Sawyer; D Cababa; R M Hendry; P L Nara; Dennis R Burton
In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3809-13.
1994: Henrik J Ditzel; S M Barbas; Carlos F Barbas; Dennis R Burton
The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3710-4.
1994: James Crowe; Brian Murphy; Robert M Chanock; R Anthony Williamson; Carlos F Barbas; Dennis R Burton
Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1386-90.
1994: R Burioni; R Anthony Williamson; PP Sanna; F E Bloom; Dennis R Burton
Recombinant human Fab to glycoprotein D neutralizes infectivity and prevents cell-to-cell transmission of herpes simplex viruses 1 and 2 in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):355-9.
1994: Dennis R Burton; Carlos F Barbas
Human antibodies from combinatorial libraries.
Advances in immunology 1994;57():191-280.
1994: E Bender; Glenn Pilkington; Dennis R Burton
Human monoclonal Fab fragments from a combinatorial library prepared from an individual with a low serum titer to a virus.
Human antibodies and hybridomas 1994;5(1-2):3-8.
1993: M Sasano; Dennis R Burton; Gregg J Silverman
Molecular selection of human antibodies with an unconventional bacterial B cell antigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5822-39.
1993: Robert M Chanock; James Crowe; Brian Murphy; Dennis R Burton
Human monoclonal antibody Fab fragments cloned from combinatorial libraries: potential usefulness in prevention and/or treatment of major human viral diseases.
Infectious agents and disease 1993;2(3):118-31.
1993: R Anthony Williamson; R Burioni; PP Sanna; L J Partridge; Carlos F Barbas; Dennis R Burton
Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4141-5.
1993: Dennis R Burton; Carlos F Barbas
Human antibodies to HIV-1 by recombinant DNA methods.
Chemical immunology 1993;56():112-26.
1992: Richard A Lerner; Angray S Kang; J D Bain; Dennis R Burton; Carlos F Barbas
Antibodies without immunization.
Science (New York, N.Y.) 1992;258(5086):1313-4.
1992: T A Collet; P Roben; R O'Kennedy; Carlos F Barbas; Dennis R Burton; Richard A Lerner
A binary plasmid system for shuffling combinatorial antibody libraries.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10026-30.
1992: Carlos F Barbas; James Crowe; D Cababa; T M Jones; S L Zebedee; Brian Murphy; Robert M Chanock; Dennis R Burton
Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10164-8.
1992: Dennis R Burton
Human monoclonal antibodies: achievement and potential.
Hospital practice (Office ed.) 1992;27(8):67-74.
1992: S L Zebedee; Carlos F Barbas; Y L Hom; R H Caothien; R Graff; J DeGraw; J Pyati; R LaPolla; Dennis R Burton; R A Lerner
Human combinatorial antibody libraries to hepatitis B surface antigen.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3175-9.
1992: Michel A Duchosal; S A Eming; P Fischer; D Leturcq; Carlos F Barbas; P J McConahey; R H Caothien; george thornton; F J Dixon; Dennis R Burton
Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries.
Nature 1992;355(6357):258-62.
1992: Dennis R Burton; J M Woof
Human antibody effector function.
Advances in immunology 1992;51():1-84.
1991: Angray S Kang; T M Jones; Dennis R Burton
Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11120-3.
1991: Dennis R Burton; Carlos F Barbas; Mats A A Persson; Scott Koenig; Robert M Chanock; Richard A Lerner
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10134-7.
1991: Richard A Lerner; Carlos F Barbas; Angray S Kang; Dennis R Burton
On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9705-6.