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Dirk Reinhardt

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R Beier; Arndt Borkhardt; U Creutzig; Karoline Ehlert; Matthias Eyrich; Johann Greil; Bernd Gruhn; Rupert Handgretinger; W Holter; Thomas Klingebiel; Bernhard Kremens; Peter Lang; C Mauz-Körholz; R Meisel; I Müller; Christina Peters; Dirk Reinhardt; André Schrauder; Ansgar Schulz; F R Schuster; Petr Sedlacek; Brigitte Strahm; Karl-Walter Sykora; Wilhelm Wössmann; Martin Zimmermann; Michael H Albert; Peter Bader; M G Sauer
Allo-SCT using BU, CY and melphalan for children with AML in second CR.
M C H Hermkens; Rob Pieters; Dirk Reinhardt; Jan Stary; Marry M van den Heuvel-Eibrink; M Zimmerman; S T C J M Arentsen-Peters; A Baruchel; V de Haas; Christian M Zwaan
The clinical relevance of BAALC and ERG expression levels in pediatric AML.
Basant Kumar Thakur; Annette Becker; Prakash Chandra; Tino Dittrich; Jan-Henning Klusmann; Wolfgang Kuehnau; Dirk Reinhardt; Karl Welte
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.

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2013: R Beier; Arndt Borkhardt; U Creutzig; Karoline Ehlert; Matthias Eyrich; Johann Greil; Bernd Gruhn; Rupert Handgretinger; W Holter; Thomas Klingebiel; Bernhard Kremens; Peter Lang; C Mauz-Körholz; R Meisel; I Müller; Christina Peters; Dirk Reinhardt; André Schrauder; Ansgar Schulz; F R Schuster; Petr Sedlacek; Brigitte Strahm; Karl-Walter Sykora; Wilhelm Wössmann; Martin Zimmermann; Michael H Albert; Peter Bader; M G Sauer
Allo-SCT using BU, CY and melphalan for children with AML in second CR.
Bone marrow transplantation 2013;48(5):651-6.
2013: M C H Hermkens; Rob Pieters; Dirk Reinhardt; Jan Stary; Marry M van den Heuvel-Eibrink; M Zimmerman; S T C J M Arentsen-Peters; A Baruchel; V de Haas; Christian M Zwaan
The clinical relevance of BAALC and ERG expression levels in pediatric AML.
Leukemia 2013;27(3):735-7.
2013: Basant Kumar Thakur; Annette Becker; Prakash Chandra; Tino Dittrich; Jan-Henning Klusmann; Wolfgang Kuehnau; Dirk Reinhardt; Karl Welte
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.
International journal of cancer. Journal international du cancer 2013;132(4):766-74.
2013: Gertjan J L Kaspers; Guy G Leverger; Alexei Maschan; Bassem I Razzouk; Dirk Reinhardt; Carmelo Rizzari; Petr Smisek; Owen Smith; Batia Stark; Rienk Y J Tamminga; Martin Zimmermann; Olga Aleinikova; Hortensia Armendariz; Yves Bertrand; Michael Dworzak; Brenda E S Gibson; Shau-Yin Ha; Henrik Hasle; Liisa Hovi; Ursula Creutzig
Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the International BFM Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(5):599-607.
2013: Anna M Aalbers; Andre Baruchel; Rodrigo T Calado; Valerie de Haas; Karin Geleijns; Sachiko Kajigaya; Gertjan J L Kaspers; Taco W Kuijpers; Rob Pieters; Dirk Reinhardt; Jan Trka; Vincent H J van der Velden; Neal S Young; C Michel Zwaan; Marry M van den Heuvel-Eibrink
Absence of SBDS mutations in sporadic paediatric acute myeloid leukaemia.
British journal of haematology 2013;160(4):559-61.
2013: Mahban Irandoust; G J L Kaspers; Pamela Kearns; Dirk Reinhardt; Karin Schornagel; Edwin Sonneveld; Peter J Valk; Ellen M van Beek; Arjan A van de Loosdrecht; Mercan Akyuz; Julian Alvarez Zarate; A J F Broekhuizen; Jacqueline Cloos; Eva A Coenen; Ursula Creutzig; Eveline S J M de Bont; Ruud Delwel; Isabelle Hubeek; Marry M van den Heuvel-Eibrink; Christian M Zwaan; Timo K van den Berg
Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
PloS one 2013;8(1):e52143.
2012: Eva A Coenen; Eveline S J M de Bont; Valerie de Haas; Emma M C Driessen; G J L Kaspers; Rolf Marschalek; Claus Meyer; Rob Pieters; Dirk Reinhardt; Ronald W Stam; Jan Stary; Susan T C J M Arentsen-Peters; Andre Baruchel; Christian M Zwaan; Marry M van den Heuvel-Eibrink
CBL mutations do not frequently occur in paediatric acute myeloid leukaemia.
British journal of haematology 2012;159(5):577-84.
2012: Stephan Emmrich; Jan Hegermann; Kerstin Henke; Matthias Ochs; Dirk Reinhardt; Jan-Henning Klusmann
miRNAs can increase the efficiency of ex vivo platelet generation.
Annals of hematology 2012;91(11):1673-84.
2012: Clarisse Thiollier; William Vainchenker; Qiang Wen; Arnaud Petit; Françoise Pflumio; Sandrine Poglio; Isabelle Radford; Dirk Reinhardt; Paola Rivera-Munoz; Paola Ballerini; Anne-Laure Bauchet; Olivier A Bernard; Olivier Bluteau; Beat Bornhauser; Jean-Pierre Bourquin; John D Crispino; Nicole Dastugue; Stéphane de Botton; Philippe Dessen; M'boyba Diop; Yannis Duffourd; Daniel Gautheret; Bastien Gerby; Justine Guégan; Cathy Ignacimouttou; Judith Landman-Parker; Yann Lecluse; Cécile K Lopez; Vinciane Mabialah; Thomas Mercher
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
The Journal of experimental medicine 2012;209(11):2017-31.
2012: Ursula Creutzig; Eveline S J M de Bont; Michael Dworzak; Brenda Gibson; Jochen Harbott; Henrik Hasle; Donna Johnston; G J L Kaspers; Akitoshi Kinoshita; Thomas Lehrnbecher; Guy Leverger; Ester Mejstrikova; Soheil Meshinchi; Andrea Pession; Susana C Raimondi; Dirk Reinhardt; Jan Stary; Lillian Sung; Marry M van den Heuvel-Eibrink; Christian M Zwaan; Souichi Adachi
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Blood 2012;120(16):3187-205.
2012: Dirk Reinhardt; A Sander; C Von Neuhoff; U Creutzig
[Genetic prognostic factors in childhood acute myeloid leukemia].
Klinische Pädiatrie 2012;224(6):372-6.
2012: Maaike Luesink; Dirk Reinhardt; Jan Trka; Marry M van den Heuvel-Eibrink; Bert A van der Reijden; Vincent H J van der Velden; C Michel Zwaan; Andre Baruchel; Jan B M Boezeman; Valérie de Haas; Iris H I M Hollink; Ruth H J N Knops; Joop H Jansen
High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia.
Blood 2012;120(10):2064-75.
2012: Benjamin Gross; Erik Pittermann; Dirk Reinhardt; Tobias Cantz; Jan-Henning Klusmann
Prospects and challenges of reprogrammed cells in hematology and oncology.
Pediatric hematology and oncology 2012;29(6):507-28.
2012: Marjolein Blink; Rodrigo T Calado; Valerie de Haas; Henrik Hasle; Iris H I M Hollink; Jan-Henning Klusmann; Jules P P Meijerink; Rob Pieters; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; V H J van der Velden; Anna M Aalbers; Brian Balgobind; Berna H Beverloo; Christian M Zwaan
High frequency of copy number alterations in myeloid leukaemia of Down syndrome.
British journal of haematology 2012;158(6):800-3.
2012: Basant Kumar Thakur; Annette Becker; Prakash Chandra; Tino Dittrich; Jan-Henning Klusmann; Yannick Lippka; Dirk Reinhardt; Divakarvel Selvakumar; Karl Welte
Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells.
Biochemical and biophysical research communications 2012;424(3):371-7.
2012: Felicitas Thol; Nils von neuhoff; Martijn H Brugman; Frederik Damm; Arnold Ganser; Jan-Henning Klusmann; Britta Kölking; Jürgen Krauter; Dirk Reinhardt; Katarina Reinhardt; Brigitte Schlegelberger; Sebastian Suerbaum; Michael Heuser
Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations.
Genes, chromosomes & cancer 2012;51(7):689-95.
2012: Astrid A Danen-van Oorschot; Valerie de Haas; Jenny E Kuipers; Rob Pieters; Dirk Reinhardt; Diana Schotte; Jan Trka; Susan Arentsen-Peters; André Baruchel; C Michel Zwaan; Marry M van den Heuvel-Eibrink
Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.
Pediatric blood & cancer 2012;58(5):715-21.
2012: Dirk Reinhardt; K Reinhardt; C Rössig; A Sander; A Sauerbrey; Arend von Stackelberg; Ursula Creutzig; Jan-Henning Klusmann; C Neuhoff; Arnulf Pekrun; A Kolenova
[GATA1-mutation associated leukemia in children with trisomy 21 mosaic].
Klinische Pädiatrie 2012;224(3):153-5.
2012: Susanne Haemmerling; S Hentze; Johannes W G Janssen; Anna Jauch; Karin A Koch; Jan O Korbel; Obul R Bandapalli; Claus R Bartram; Wolfgang Behnisch; Michael Bonin; Peer Bork; Tobias Doerks; Ute Grasshoff; Ute Moog; Dirk Reinhardt; Olaf Rieß; Andreas E Kulozik
A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL.
British journal of haematology 2012;157(2):180-7.
2012: Lan Dan; Olga Klimenkova; Maxim Klimiankou; Jan-Henning Klusman; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; Karl Welte; Julia Skokowa
The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Haematologica 2012;97(4):551-9.
2012: Ursula Creutzig; Michael Dworzak; Bernhard Kremens; T Lehrnbecher; J-P Bourquin; Annette Sander; I Schmid; J Starý; Daniel Steinbach; C von Neuhoff; Arend von Stackelberg; Josef Vormoor; Martin Zimmermann; Dirk Reinhardt
Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report.
Leukemia 2012;26(4):654-61.
2012: I H I M Hollink; Rob Pieters; Dirk Reinhardt; Jan Trka; Marry M van den Heuvel-Eibrink; L J Verboon; J Wang; P Zhang; S T C J M Arentsen-Peters; Ursula Creutzig; A A Danen-van Oorschot; V de Haas; Q Feng; Christian M Zwaan
Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model.
Leukemia 2012;26(2):371-3.
2012: Kerstin Kremeike; Nina Eulitz; Max Geraedts; Brigitte Sens; Dirk Reinhardt
[Quality management in implementing specialist pediatric palliative home care in Lower Saxony, Germany].
Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen 2012;106(8):584-94.
2012: Kerstin Kremeike; Nina Eulitz; Max Geraedts; Saskia Jünger; Annette Sander; Dirk Reinhardt
Paediatric palliative home care in areas of Germany with low population density and long distances: a questionnaire survey with general paediatricians.
BMC research notes 2012;5():498.
2012: Jan-Henning Klusmann; Bernhard Kremens; Ursula Creutzig; Josef Vormoor; Michael Dworzak; Martin Zimmermann; Dirk Reinhardt; Thomas Klingebiel
The role of matched sibling donor allogeneic stem cell transplantation in pediatric high-risk acute myeloid leukemia: results from the AML-BFM 98 study.
Haematologica 2012;97(1):21-9.
2012: Friederike Schneider; Annika Dufour; Christian Thiede; Michaela Feuring-Buske; Wolfgang E Berdel; Eva Hoster; Marry M van den Heuvel-Eibrink; Ursula Creutzig; Maria C Sauerland; Stefan K Bohlander; Bernhard J Woermann; Jan Braess; Tobias Benthaus; Purvi M Kakadia; Thomas Buechner; Achim Heinecke; Stephanie Schneider; Dirk Reinhardt; Michel C Zwaan; Christian Buske; Wolfgang Hiddemann; Karsten Spiekermann
Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).
Annals of hematology 2012;91(1):9-18.
2011: Ursula Creutzig; Michael N Dworzak; Gudrun Fleischhack; Joerg Ritter; Annette Sander; André Schrauder; Jan Starý; Christine von Neuhoff; Arend von Stackelberg; Martin Zimmermann; Jean-Pierre Bourquin; Dirk Reinhardt
CNS irradiation in pediatric acute myleoid leukemia: equal results by 12 or 18 Gy in studies AML-BFM98 and 2004.
Pediatric blood & cancer 2011;57(6):986-92.
2011: Ursula Creutzig; Michael Dworzak; Jean-Pierre Bourquin; Selim Corbacioglu; Annette Sander; André Schrauder; Jan Stary; Andrea Teigler-Schlegel; Christine von Neuhoff; Martin Zimmermann; Dirk Reinhardt
Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16).
Blood 2011;118(20):5409-15.
2011: Daniel Steinbach; Brigitte Strahm; Arend von Stackelberg; Bernhard Wilhelm; Martin Zimmermann; Ursula Creutzig; Klaus-Michael Debatin; Bernd Gruhn; Heribert Jürgens; Hans-Rudolf Kiermaier; Dirk Reinhardt; Martin Schrappe; Anja Möricke
Long term survival in children with acute leukaemia and complications requiring mechanical ventilation.
Archives of disease in childhood 2011;96(11):1026-32.
2011: F Damm; V de Haas; Arnold Ganser; Michael Heuser; I Hollink; Jan-Henning Klusmann; J Krauter; Dirk Reinhardt; K Reinhardt; F Thol; Marry M van den Heuvel-Eibrink; Martin Zimmermann; Christian M Zwaan; Ursula Creutzig; C Thiede
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups.
Leukemia 2011;25(11):1704-10.
2011: Brian Balgobind; Andre Baruchel; Berna Beverloo; Jean-Michel Cayuela; Jacqueline Cloos; Ursula Creutzig; Valerie de Haas; Jochen Harbott; Iris H I M Hollink; G J L Kaspers; Rob Pieters; Dirk Reinhardt; Jan Stary; Anne R M von Bergh; Zuzana Zemanova; Martin Zimmermann; Christian M Zwaan; Susan T C J M Arentsen-Peters; Marry M van den Heuvel-Eibrink
Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia.
Haematologica 2011;96(10):1478-87.
2011: M Malaisé; M Neumeier; Dirk Reinhardt; Brigitte Schlegelberger; Klaus-Michael Debatin; K Döhner; G Göhring; Bernd Gruhn; Catherine Botteron; Selim Corbacioglu
Stable and reproducible engraftment of primary adult and pediatric acute myeloid leukemia in NSG mice.
Leukemia 2011;25(10):1635-9.
2011: Iris H I M Hollink; Gert-Jan J L Kaspers; Jenny E Kuipers; Rob Pieters; Marta Pratcorona; Dirk Reinhardt; Edwin Sonneveld; Jan Trka; Peter J M Valk; Marry M van den Heuvel-Eibrink; Janneke F van Galen; Martin Zimmermann; Saman Abbas; Susan T C J M Arentsen-Peters; Andre Baruchel; Berna Beverloo; Ursula Creutzig; Christian M Zwaan
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.
Blood 2011;118(13):3645-56.
2011: Kate A Alford; Katarina Böhmer; Catherine Garnett; Henrik Hasle; Jan-Henning Klusmann; Alexandra Kolenova; Emanuele Marchi; Alice Norton; Dirk Reinhardt; Katarina Reinhardt; Irene Roberts; Christine von Neuhoff; Paresh Vyas
Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia.
Blood 2011;118(8):2222-38.
2011: Felicitas Thol; Katarina Reinhardt; Frederik Damm; Michael Heuser; Jan-Henning Klusmann; Dirk Reinhardt
DNMT3A mutations are rare in childhood acute myeloid leukemia.
Haematologica 2011;96(8):1238-40.
2011: M Blink; T D Buitenkamp; A J Carroll; A A Danen-van Oorschot; V de Haas; Meenakshi Devidas; H Hasle; S Izraeli; Jan-Henning Klusmann; A Pession; Rob Pieters; Karen Rabin; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; Martin Zimmermann; G Basso; Christian M Zwaan
Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.
Leukemia 2011;25(8):1365-8.
2011: Carolin Hartmann; Christin Linderkamp; Lorenz Grigull; Anette Sander; Hansjörg Schmid; Peter Weinel; Karl Welte; Dirk Reinhardt
Oxaliplatin, irinotecan, and gemcitabine: a novel combination in the therapy of progressed, relapsed, or refractory tumors in children.
Journal of pediatric hematology/oncology 2011;33(5):344-9.
2011: Eva A Coenen; Ursula Creutzig; Michael N Dworzak; Erik Forestier; Brenda Gibson; Jochen Harbott; Christine J Harrison; Henrik Hasle; Nyla A Heerema; Gertjan J L Kaspers; Anna Leszl; Nathalia Litvinko; Luca Lo Nigro; Akira Morimoto; Christine Perot; Rob Pieters; Susana C Raimondi; Dirk Reinhardt; Jeffrey E Rubnitz; Franklin O Smith; Jan Stary; Irina Stasevich; Sabine Strehl; Takashi Taga; Daisuke Tomizawa; Todd A Alonzo; Anne Auvrignon; H Berna Beverloo; Myron Chang; David Webb; Zuzana Zemanova; Martin Zimmermann; C Michel Zwaan; Marry M van den Heuvel-Eibrink
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study.
Blood 2011;117(26):7102-11.
2011: Iris H I M Hollink; Marry M van den Heuvel-Eibrink; Susan T C J M Arentsen-Peters; Martin Zimmermann; Justine K Peeters; Peter J M Valk; Brian Balgobind; Edwin Sonneveld; Gertjan J L Kaspers; Eveline S J M de Bont; Jan Trka; Andre Baruchel; Ursula Creutzig; Rob Pieters; Dirk Reinhardt; Christian M Zwaan
Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.
Haematologica 2011;96(3):384-92.
2011: Brian Balgobind; Marry M van den Heuvel-Eibrink; Renee X De Menezes; Dirk Reinhardt; Iris H I M Hollink; Susan T J C M Arentsen-Peters; Elisabeth R van Wering; Gertjan J L Kaspers; Jacqueline Cloos; Eveline S J M de Bont; Jean-Michel Cayuela; Andre Baruchel; Claus Meyer; Rolf Marschalek; Jan Trka; Jan Stary; Berna Beverloo; Rob Pieters; Christian M Zwaan; Monique L den Boer
Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.
Haematologica 2011;96(2):221-30.
2011: Jenny E Kuipers; Eva A Coenen; Brian Balgobind; Jan Stary; Andre Baruchel; Valerie de Haas; Eveline S J M de Bont; Dirk Reinhardt; G J L Kaspers; Jacqueline Cloos; Astrid A Danen-van Oorschot; Monique L den Boer; Rolf Marschalek; Claus Meyer; Rob Pieters; Christian M Zwaan; Marry M van den Heuvel-Eibrink
High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23).
Blood 2011;117(3):928-35.
2010: Brian Balgobind; Christian M Zwaan; Dirk Reinhardt; T J C M Arentsen-Peters; I H I M Hollink; V de Haas; G J L Kaspers; Eveline S J M de Bont; A Baruchel; Jan Stary; Claus Meyer; Rolf Marschalek; Ursula Creutzig; Monique L den Boer; Rob Pieters; Marry M van den Heuvel-Eibrink
High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome.
Leukemia 2010;24(12):2048-55.
2010: Costa Bachas; Gerrit Jan Schuurhuis; Iris H I M Hollink; Zinia J Kwidama; Bianca F Goemans; Christian M Zwaan; Marry M van den Heuvel-Eibrink; Eveline S J M de Bont; Dirk Reinhardt; Ursula Creutzig; Valerie de Haas; Yehuda G Assaraf; Gertjan J L Kaspers; Jacqueline Cloos
High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine.
Blood 2010;116(15):2752-8.
2010: Kerstin Kremeike; Annette Sander; Nina Eulitz; Dirk Reinhardt
[Specialized ambulatory pediatric palliative care (SAPPV) - a concept for implementing comprehensive care in Lower Saxony].
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft für Sozialpädiatrie und Deutsche Gesellschaft für Kinderheilkunde 2010;29(10):419-23.
2010: Iris H I M Hollink; Marry M van den Heuvel-Eibrink; Martin Zimmermann; Brian Balgobind; Susan T C J M Arentsen-Peters; Marielle Alders; Andre Willasch; Gert-Jan J L Kaspers; Jan Trka; Andre Baruchel; Ursula Creutzig; Rob Pieters; Dirk Reinhardt; C Michel Zwaan
No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(28):e523-6; author reply e527-e528.
2010: Bianca F Goemans; Christian M Zwaan; Jacqueline Cloos; Desiree de Lange; Anne H Loonen; Dirk Reinhardt; Karel Hählen; Brenda E S Gibson; Ursula Creutzig; G J L Kaspers
FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657.
Leukemia research 2010;34(10):1302-7.
2010: Jan-Henning Klusmann; Frank J Godinho; Kirsten Heitmann; Aliaksandra Maroz; Mia Lee Koch; Dirk Reinhardt; Stuart H Orkin; Zhe Li
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis.
Genes & development 2010;24(15):1659-72.
2010: Annette Sander; Martin Zimmermann; Michael Dworzak; Gudrun Fleischhack; C von Neuhoff; Dirk Reinhardt; G J L Kaspers; Ursula Creutzig
Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials.
Leukemia 2010;24(8):1422-8.
2010: Brian Balgobind; Iris H I M Hollink; Dirk Reinhardt; Elisabeth R van Wering; Siebold S N de Graaf; Andre Baruchel; Jan Stary; Berna Beverloo; Georgine E De Greef; Rob Pieters; Christian M Zwaan; Marry M van den Heuvel-Eibrink
Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique.
European journal of cancer (Oxford, England : 1990) 2010;46(10):1892-9.
2010: Christine von Neuhoff; Dirk Reinhardt; Annette Sander; Martin Zimmermann; Jutta Bradtke; David R Betts; Zuzana Zemanova; Jan Stary; Jean-Pierre Bourquin; Oskar A Haas; Michael Dworzak; Ursula Creutzig
Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(16):2682-9.
2010: Stephanie Ehlers; Christin Herbst; Martin Zimmermann; Nicole Scharn; Manuela Germeshausen; Nils von neuhoff; Christian Michel Zwaan; Katarina Reinhardt; Iris H Hollink; Jan-Henning Klusmann; Thomas Lehrnbecher; Silja Roettgers; Jan Stary; Michael Dworzak; Karl Welte; Ursula Creutzig; Dirk Reinhardt
Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(15):2591-7.
2010: Brian Balgobind; S Lugthart; I H Hollink; S T J C M Arentsen-Peters; Elisabeth R van Wering; Siebold S N de Graaf; Dirk Reinhardt; Ursula Creutzig; G J L Kaspers; E S J M de Bont; Jan Stary; Jan Trka; M Zimmermann; Berna Beverloo; Rob Pieters; Ruud Delwel; Christian M Zwaan; Marry M van den Heuvel-Eibrink
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia.
Leukemia 2010;24(5):942-9.
2010: Ursula Creutzig; Martin Zimmermann; Michael Dworzak; Christian Urban; Günter Henze; Bernhard Kremens; Max Lakomek; Jean-Pierre Bourquin; Jan Stary; Dirk Reinhardt
Favourable outcome of patients with childhood acute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses.
British journal of haematology 2010;149(3):399-409.
2010: Heidrun Gerr; Martin Zimmermann; Martin Schrappe; Michael Dworzak; Wolf-Dieter Ludwig; Jutta Bradtke; Anja Moericke; Richard Schabath; Ursula Creutzig; Dirk Reinhardt
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
British journal of haematology 2010;149(1):84-92.
2010: Jan-Henning Klusmann; Zhe Li; Katarina Böhmer; Aliaksandra Maroz; Mia Lee Koch; Stephan Emmrich; Frank J Godinho; Stuart H Orkin; Dirk Reinhardt
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.
Genes & development 2010;24(5):478-90.
2010: Christian M Zwaan; Dirk Reinhardt; Martin Zimmerman; Henrik Hasle; Jan Stary; Batia Stark; Michael Dworzak; Ursula Creutzig; G J L Kaspers
Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study.
British journal of haematology 2010;148(5):768-76.
2010: C Michel Zwaan; Dirk Reinhardt; Johann Hitzler; Paresh Vyas
Acute leukemias in children with Down syndrome.
Hematology/oncology clinics of North America 2010;24(1):19-34.
2009: Thomas Lehrnbecher; Marie-Chantal Ethier; Theoklis Zaoutis; Ursula Creutzig; Alan Gamis; Dirk Reinhardt; Richard Aplenc; Lillian Sung
International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia.
British journal of haematology 2009;147(1):125-8.
2009: Brian Balgobind; Susana C Raimondi; Jochen Harbott; Martin Zimmermann; Todd A Alonzo; Anne Auvrignon; Berna Beverloo; Myron Chang; Ursula Creutzig; Michael N Dworzak; Erik Forestier; Brenda Gibson; Henrik Hasle; Christine J Harrison; Nyla A Heerema; Gertjan J L Kaspers; Anna Leszl; Nathalia Litvinko; Luca Lo Nigro; Akira Morimoto; Christine Perot; Rob Pieters; Dirk Reinhardt; Jeffrey E Rubnitz; Franklin O Smith; Jan Stary; Irina Stasevich; Sabine Strehl; Takashi Taga; Daisuke Tomizawa; David Webb; Zuzana Zemanova; C Michel Zwaan; Marry M van den Heuvel-Eibrink
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.
Blood 2009;114(12):2489-96.
2009: A M Willasch; B Gruhn; T Coliva; M Kalinova; G Schneider; Hermann Kreyenberg; D Steinbach; G Weber; I H I M Hollink; Christian M Zwaan; A Biondi; V H J van der Velden; Dirk Reinhardt; G Cazzaniga; Peter Bader; Jan Trka
Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study.
Leukemia 2009;23(8):1472-9.
2009: Iris H I M Hollink; Marry M van den Heuvel-Eibrink; Martin Zimmermann; Brian Balgobind; Susan T C J M Arentsen-Peters; Marielle Alders; Andre Willasch; G J L Kaspers; Jan Trka; Andre Baruchel; Siebold S N de Graaf; Ursula Creutzig; Rob Pieters; Dirk Reinhardt; Christian M Zwaan
Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia.
Blood 2009;113(23):5951-60.
2009: I H I M Hollink; Christian M Zwaan; M Zimmermann; T C J M Arentsen-Peters; Rob Pieters; J Cloos; G J L Kaspers; Siebold S N de Graaf; J Harbott; U Creutzig; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; C Thiede
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML.
Leukemia 2009;23(2):262-70.
2009: N Scharn; Matthias Ballmaier; K Reinhardt; S Ehlers; M Zimmermann; K Welte; Dirk Reinhardt; M Germeshausen
CSF3R mutations in paediatric acute myeloid leukaemia.
British journal of haematology 2009;144(1):140-2.
2008: B F Goemans; C M Zwaan; S J H Vijverberg; A H Loonen; U Creutzig; K Hählen; Dirk Reinhardt; B E S Gibson; J Cloos; G J L Kaspers
Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia.
Leukemia 2008;22(12):2284-5.
2008: Sebastien Malinge; Christine Ragu; Véronique Della Valle; Didier F Pisani; Stefan N Constantinescu; Christelle Perez; Jean-Luc Villeval; Dirk Reinhardt; Judith Landman-Parker; Lucienne Michaux; Nicole Dastugue; André Baruchel; William Vainchenker; Jean-Pierre Bourquin; Virginie Penard-Lacronique; Olivier A Bernard
Activating mutations in human acute megakaryoblastic leukemia.
Blood 2008;112(10):4220-6.
2008: Thomas Klingebiel; Dirk Reinhardt; Peter Bader
Place of HSCT in treatment of childhood AML.
Bone marrow transplantation 2008;42 Suppl 2():S7-9.
2008: Bjoern Chapuy; R Koch; U Radunski; S Corsham; N Cheong; N Inagaki; N Ban; Dirk Wenzel; Dirk Reinhardt; A Zapf; Stefan Schweyer; F Kosari; W Klapper; Lorenz Truemper; Gerald G Wulf
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration.
Leukemia 2008;22(8):1576-86.
2008: H Hasle; J Abrahamsson; M Arola; A Karow; A O'Marcaigh; Dirk Reinhardt; D K H Webb; E van Wering; B Zeller; C M Zwaan; P Vyas
Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML.
Leukemia 2008;22(7):1428-30.
2008: Brian Balgobind; Pieter Van Vlierberghe; Ans M W van den Ouweland; Berna Beverloo; Joan N R Terlouw-Kromosoeto; Elisabeth R van Wering; Dirk Reinhardt; Martin Horstmann; G J L Kaspers; Rob Pieters; Christian M Zwaan; Marry M van den Heuvel-Eibrink; Jules P P Meijerink
Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis.
Blood 2008;111(8):4322-8.
2008: Jan-Henning Klusmann; Ursula Creutzig; Martin Zimmermann; Michael Dworzak; Norbert Jorch; Claudia Langebrake; Arnulf Pekrun; Katarina Macakova-Reinhardt; Dirk Reinhardt
Treatment and prognostic impact of transient leukemia in neonates with Down syndrome.
Blood 2008;111(6):2991-8.
2008: Lüder Hinrich Meyer; Manon Queudeville; Sarah M Eckhoff; Ursula Creutzig; Dirk Reinhardt; Leonid Karawajew; Wolf-Dieter Ludwig; Karsten Stahnke; Klaus-Michael Debatin
Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.
Blood 2008;111(5):2899-903.
2008: Michel C Zwaan; Dirk Reinhardt; Johann Hitzler; Paresh Vyas
Acute leukemias in children with Down syndrome.
Pediatric clinics of North America 2008;55(1):53-70, x.
2008: Ursula Creutzig; Thomas Büchner; Maria C Sauerland; Martin Zimmermann; Dirk Reinhardt; Hartmut Döhner; Richard F Schlenk
Significance of age in acute myeloid leukemia patients younger than 30 years: a common analysis of the pediatric trials AML-BFM 93/98 and the adult trials AMLCG 92/99 and AMLSG HD93/98A.
Cancer 2008;112(3):562-71.
2008: Corine J Hess; Najim Ameziane; Gerrit J Schuurhuis; a Errami; Fedor Denkers; G J L Kaspers; Jacqueline Cloos; Hans Joenje; Dirk Reinhardt; Gert Ossenkoppele; Christian M Zwaan; Quinten Waisfisz
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(4):299-306.
2007: Stefan Gattenloehner; Sergei Chuvpilo; Claudia Langebrake; Dirk Reinhardt; Hans Konrad Müller-Hermelink; Edgar Serfling; Angela Vincent; Alexander Marx
Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression.
Blood 2007;110(6):2027-33.
2007: Jan-Henning Klusmann; Dirk Reinhardt; Henrik Hasle; G J Kaspers; U Creutzig; K Hahlen; Marry M van den Heuvel-Eibrink; C M Zwaan
Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome.
Leukemia 2007;21(7):1584-7.
2007: Ursula Creutzig; Sylke Diekamp; Martin Zimmermann; Dirk Reinhardt
Longitudinal evaluation of early and late anthracycline cardiotoxicity in children with AML.
Pediatric blood & cancer 2007;48(7):651-62.
2007: Henrik Hasle; Todd A Alonzo; Anne Auvrignon; Catherine Behar; Myron Chang; Ursula Creutzig; Alexandra Fischer; Erik Forestier; Alcira Fynn; Oskar A Haas; Jochen Harbott; Christine J Harrison; Nyla A Heerema; Marry M van den Heuvel-Eibrink; Gertjan J L Kaspers; Franco Locatelli; Peter Noellke; Sophia Polychronopoulou; Yaddanapudi Ravindranath; Bassem Razzouk; Dirk Reinhardt; Natalia N Savva; Batia Stark; Stefan Suciu; Ichiro Tsukimoto; David K Webb; Dorora Wojcik; William G Woods; Martin Zimmermann; Charlotte M Niemeyer; Susana C Raimondi
Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.
Blood 2007;109(11):4641-7.
2007: Claudia Langebrake; Kalle Günther; Jürgen Lauber; Dirk Reinhardt
Preanalytical mRNA stabilization of whole bone marrow samples.
Clinical chemistry 2007;53(4):587-93.
2007: Christian Thiede; Eva Creutzig; Dirk Reinhardt; Gerhard Ehninger; U Creutzig
Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12.
Leukemia 2007;21(2):366-7.
2007: Thomas Lehrnbecher; Martin Zimmermann; Dirk Reinhardt; Michael Dworzak; Jan Stary; Ursula Creutzig
Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia.
Blood 2007;109(3):936-43.
2006: Soheil Meshinchi; Todd A Alonzo; Derek L Stirewalt; Michel Zwaan; Martin Zimmerman; Dirk Reinhardt; G J L Kaspers; Nyla A Heerema; Robert B Gerbing; Beverly J Lange; Jerald P Radich
Clinical implications of FLT3 mutations in pediatric AML.
Blood 2006;108(12):3654-61.
2006: Mehtap Kilic; Mehtap Kilic; Mike-Andrew Westhoff; Dirk Reinhardt; Simone Fulda; Klaus-Michael Debatin
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin.
Blood 2006;108(10):3504-13.
2006: Bianca Goemans; Christian M Zwaan; Dirk Reinhardt; Brenda E S Gibson; Karel Hählen; G J L Kaspers
A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia.
Haematologica 2006;91(11):1573-4.
2006: Claudia Langebrake; Jan-Henning Klusmann; Kristina Wortmann; Miriam Kolar; Ulrike Puhlmann; Dirk Reinhardt
Concomitant aberrant overexpression of RUNX1 and NCAM in regenerating bone marrow of myeloid leukemia of Down's syndrome.
Haematologica 2006;91(11):1473-80.
2006: G J L Kaspers; Dirk Reinhardt; Gudrun Fleischhack; H Armendariz; Batia Stark; Christian M Zwaan; Martin Zimmermann; Ursula Creutzig
Low efficacy of methotrexate in childhood acute myeloid leukemia (AML): single-agent therapeutic window study in relapsed AML.
Pediatric blood & cancer 2006;47(5):539-42.
2006: Ursula Creutzig; Martin Zimmermann; Thomas Lehrnbecher; Norbert Graf; Johann Hermann; Charlotte M Niemeyer; Alfred Reiter; Jörg Ritter; Michael Dworzak; Jan Stary; Dirk Reinhardt
Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(27):4499-506.
2006: Claudia Langebrake; Ursula Creutzig; Michael Dworzak; Ondrej Hrusak; Ester Mejstrikova; Frank Griesinger; Martin Zimmermann; Dirk Reinhardt
Residual disease monitoring in childhood acute myeloid leukemia by multiparameter flow cytometry: the MRD-AML-BFM Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(22):3686-92.
2006: Jacqueline Cloos; Bianca Goemans; Corine J Hess; Johan W van Oostveen; Quinten Waisfisz; S Corthals; Desiree de Lange; N Boeckx; Karel Hählen; Dirk Reinhardt; Ursula Creutzig; Gerrit J Schuurhuis; Ch M Zwaan; G J L Kaspers
Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples.
Leukemia 2006;20(7):1217-20.
2006: Christian M Zwaan; Monique L den Boer; Karin M Kazemier; Karel Hählen; Anne H Loonen; Dirk Reinhardt; Ursula Creutzig; G J L Kaspers; Rob Pieters
Does modulation of P-glycoprotein have clinical relevance in pediatric acute myeloid leukemia?
Blood 2006;107(12):4975-6; author reply 4976-7.
2006: J Neudenberger; Marc Hotfilder; Annegret Rosemann; Claudia Langebrake; Dirk Reinhardt; Rob Pieters; André Schrauder; Martin Schrappe; Silja Röttgers; Jochen Harbott; Josef Vormoor
Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell populations in paediatric acute myeloid leukaemia/abn(11q23) and acute lymphoblastic leukaemia/t(4;11).
British journal of haematology 2006;133(3):337-44.
2006: Dirk Reinhardt; Ralf Surber; H Kuehnert; Matthias Heinke; Hans R Figulla
[Implantation of a re-synchronization device in a patient with persistent left superior vena cava-a case report].
Herzschrittmachertherapie & Elektrophysiologie 2006;17(1):35-9.
2006: Jean-Pierre Bourquin; Aravind Subramanian; Claudia Langebrake; Dirk Reinhardt; Olivier Bernard; Paola Ballerini; André Baruchel; Hélène Cavé; Nicole Dastugue; Henrik Hasle; Gertjan L Kaspers; michel lessard; Lucienne Michaux; Paresh Vyas; Elisabeth R van Wering; Christian M Zwaan; Todd R Golub; Stuart H Orkin
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3339-44.
2005: Ursula Creutzig; M Zimmermann; J Ritter; Dirk Reinhardt; J Hermann; Günter Henze; H Jürgens; H Kabisch; Alfred Reiter; Hansjörg Riehm; Helmut Gadner; Günther Schellong
Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials.
Leukemia 2005;19(12):2030-42.
2005: Bianca Goemans; Christian M Zwaan; Amy Harlow; Anne H Loonen; Brenda E S Gibson; Karel Hählen; Dirk Reinhardt; Ursula Creutzig; Michael C Heinrich; G J L Kaspers
In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets.
Blood 2005;106(10):3532-7.
2005: Carl Friedrich Classen; A Teigler-Schlegel; S Röttgers; Dirk Reinhardt; K Döhner; Klaus-Michael Debatin
AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid.
Annals of hematology 2005;84(12):774-80.
2005: Katja Masjosthusmann; Stefan S Bielack; Gabriele Köhler; Annekathrein Florax; Manfred Schiborr; Jochen Bruch; Dirk Reinhardt; Nanna Kuhn; Michael Paulussen; Heribert Jürgens
Concomitant Ewing sarcoma and acute lymphoblastic leukemia in a 5-year-old girl.
Pediatric blood & cancer 2005;45(6):846-9.
2005: Thomas Lehrnbecher; Toralf Bernig; Mitra Hanisch; Ulrike Koehl; M Behl; Dirk Reinhardt; Ursula Creutzig; Thomas Klingebiel; STEPHEN CHANOCK; Dirk Schwabe
Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia.
Leukemia 2005;19(10):1745-50.
2005: Bianca Goemans; Christian M Zwaan; Simone Martinelli; Patina Harrell; Desiree de Lange; Claudio Carta; Dirk Reinhardt; Karel Hählen; Ursula Creutzig; Marco Tartaglia; Michael C Heinrich; G J L Kaspers
Differences in the prevalence of PTPN11 mutations in FAB M5 paediatric acute myeloid leukaemia.
British journal of haematology 2005;130(5):801-3.
2005: Bianca Goemans; Christian M Zwaan; M Miller; Martin Zimmermann; Amy Harlow; Soheil Meshinchi; Anne H Loonen; Karel Hählen; Dirk Reinhardt; Ursula Creutzig; G J L Kaspers; Michael C Heinrich
Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia.
Leukemia 2005;19(9):1536-42.
2005: Ursula Creutzig; Dirk Reinhardt; Sylke Diekamp; Michael Dworzak; Jan Stary; Martin Zimmermann
AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity.
Leukemia 2005;19(8):1355-60.
2005: Dirk Reinhardt; Sylke Diekamp; Claudia Langebrake; J Ritter; Jan Stary; Michael Dworzak; André Schrauder; Martin Zimmermann; Gudrun Fleischhack; W-D Ludwig; Jochen Harbott; Ursula Creutzig
Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment.
Leukemia 2005;19(8):1495-6.
2005: Claudia Langebrake; Ursula Creutzig; Dirk Reinhardt
Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts.
Klinische Pädiatrie 2005;217(3):126-34.
2005: Carl Friedrich Classen; Wolfgang Behnisch; Dirk Reinhardt; Margit Koenig; Peter Möller; Klaus-Michael Debatin
Spontaneous complete and sustained remission of a rearrangement CBP (16p13)-positive disseminated congenital myelosarcoma.
Annals of hematology 2005;84(4):274-5.
2005: Claudia Langebrake; Iris Brinkmann; Andrea Teigler-Schlegel; Ursula Creutzig; Frank Griesinger; Ulrike Puhlmann; Dirk Reinhardt
Immunophenotypic differences between diagnosis and relapse in childhood AML: Implications for MRD monitoring.
Cytometry. Part B, Clinical cytometry 2005;63(1):1-9.
2005: Ulrike Puhlmann; Christina Ziemann; Gudrun Ruedell; Hagen Vorwerk; Dirk Schaefer; Claudia Langebrake; Peter Schuermann; Ursula Creutzig; Dirk Reinhardt
Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells.
The Journal of pharmacology and experimental therapeutics 2005;312(1):346-54.
2004: Gerald G Wulf; Simon Modlich; Nobuya Inagaki; Dirk Reinhardt; Roland Schroers; Frank Griesinger; Lorenz Trümper
ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport.
Haematologica 2004;89(11):1395-7.
2004: Ursula Creutzig; Martin Zimmermann; Dirk Reinhardt; Michael Dworzak; Jan Stary; Thomas Lehrnbecher
Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(21):4384-93.
2004: Markus Metzler; Pamela L Strissel; Reiner Strick; Charlotte Niemeyer; Silja Roettgers; Arndt Borkhardt; Jochen Harbott; Wolf D Ludwig; Martin Stanulla; Martin Schrappe; Dirk Reinhardt; Ursula Creutzig; Jörn D Beck; Wolfgang Rascher; Roland Repp; Thorsten Langer
Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia.
Genes, chromosomes & cancer 2004;41(3):291-6.
2004: Dirk Reinhardt; Sylke Diekamp; Gudrun Fleischhack; C Corbacioglu; H Jürgens; Michael Dworzak; G J L Kaspers; Ursula Creutzig; Christian M Zwaan
Gemtuzumab ozogamicin (Mylotarg) in children with refractory or relapsed acute myeloid leukemia.
Onkologie 2004;27(3):269-72.
2004: Anja Gastmann; Holger H Sigusch; Andreas Henke; Dirk Reinhardt; Ralf Surber; Oliver Gastmann; Hans R Figulla
Role of adenosine monophosphate deaminase-1 gene polymorphism in patients with congestive heart failure (influence on tumor necrosis factor-alpha level and outcome).
The American journal of cardiology 2004;93(10):1260-4.
2004: Peter Bader; Hermann Kreyenberg; Walter Hoelle; Gregor Dueckers; Bernhard Kremens; Dagmar Dilloo; Karl-Walter Sykora; Charlotte Niemeyer; Dirk Reinhardt; Josef Vormoor; Bernd Gruhn; Peter Lang; Johann Greil; Rupert Handgretinger; Dietrich Niethammer; Thomas Klingebiel; James F Beck
Increasing mixed chimerism defines a high-risk group of childhood acute myelogenous leukemia patients after allogeneic stem cell transplantation where pre-emptive immunotherapy may be effective.
Bone marrow transplantation 2004;33(8):815-21.
2004: U Creutzig; Dirk Reinhardt; M Zimmermann
Prognostic relevance of risk groups in the pediatric AML-BFM trials 93 and 98.
Annals of hematology 2004;83 Suppl 1():S112-6.
2004: Thomas Lehrnbecher; Domenica Varwig; J Kaiser; Dirk Reinhardt; Thomas Klingebiel; Ursula Creutzig
Infectious complications in pediatric acute myeloid leukemia: analysis of the prospective multi-institutional clinical trial AML-BFM 93.
Leukemia 2004;18(1):72-7.
2003: Georg Hempel; Dirk Reinhardt; Ursula Creutzig; Joachim Boos
Population pharmacokinetics of liposomal daunorubicin in children.
British journal of clinical pharmacology 2003;56(4):370-7.
2003: Christian M Zwaan; Soheil Meshinchi; Jerald P Radich; Anjo J P Veerman; Dieuwke R Huismans; Leonhard Munske; Martina Podleschny; Karel Hählen; Rob Pieters; Martin Zimmermann; Dirk Reinhardt; Jochen Harbott; Ursula Creutzig; G J L Kaspers; Frank Griesinger
FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance.
Blood 2003;102(7):2387-94.
2003: Susanne Viehmann; Andrea Teigler-Schlegel; Jochen Bruch; Claudia Langebrake; Dirk Reinhardt; Jochen Harbott
Monitoring of minimal residual disease (MRD) by real-time quantitative reverse transcription PCR (RQ-RT-PCR) in childhood acute myeloid leukemia with AML1/ETO rearrangement.
Leukemia 2003;17(6):1130-6.
2003: Christian M Zwaan; Dirk Reinhardt; Selim Corbacioglu; Elisabeth R van Wering; Jos P M Bökkerink; Wim J E Tissing; Ulf Samuelsson; Jay Feingold; Ursula Creutzig; G J L Kaspers
Gemtuzumab ozogamicin: first clinical experiences in children with relapsed/refractory acute myeloid leukemia treated on compassionate-use basis.
Blood 2003;101(10):3868-71.
2003: Ursula Creutzig; M Zimmermann; Dirk Reinhardt; T Lehrnbecher
[Analysis of causes of death during intensive chemotherapy according to treatment protocol AML-BFM 93].
Klinische Pädiatrie 2003;215(3):151-8.
2003: Claudia Lanvers; Dirk Reinhardt; Angelika Dübbers; Alexandra Wagner-Bohn; Ursula Creutzig; Joerg Ritter; Joachim Boos
Pharmacology of all-trans-retinoic acid in children with acute promyelocytic leukemia.
Medical and pediatric oncology 2003;40(5):293-301.
2003: Thorsten Langer; Markus Metzler; Dirk Reinhardt; Susanne Viehmann; Arndt Borkhardt; Martin Reichel; Martin Stanulla; Martin Schrappe; Ursula Creutzig; Jörg Ritter; Thomas Leis; Ulla Jacobs; Jochen Harbott; Jörn D Beck; Wolfgang Rascher; Roland Repp
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.
Genes, chromosomes & cancer 2003;36(4):393-401.
2003: Olaf Witt; Sven Monkemeyer; Gabi Rönndahl; Bernhard Erdlenbruch; Dirk Reinhardt; Katrin Kanbach; Arnulf Pekrun
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
Blood 2003;101(5):2001-7.
2003: Christian M Zwaan; Dirk Reinhardt; H Jürgens; Dieuwke R Huismans; Karel Hählen; O P Smith; A Biondi; E R van Wering; J Feingold; G J L Kaspers
Gemtuzumab ozogamicin in pediatric CD33-positive acute lymphoblastic leukemia: first clinical experiences and relation with cellular sensitivity to single agent calicheamicin.
Leukemia 2003;17(2):468-70.
2003: Dirk Reinhardt; Katharina Houliara; Arnulf Pekrun; Max Lakomek; Bernd Krone
Impact of conventional chemotherapy on levels of antibodies against vaccine-preventable diseases in children treated for cancer.
Scandinavian journal of infectious diseases 2003;35(11-12):851-7.
2002: Ursula Creutzig; Dirk Reinhardt
Current controversies: which patients with acute myeloid leukaemia should receive a bone marrow transplantation?--a European view.
British journal of haematology 2002;118(2):365-77.
2002: Dirk Reinhardt; Georg Hempel; Gudrun Fleischhack; A Schulz; Joachim Boos; Ursula Creutzig
[Liposomal daunorubicine combined with cytarabine in the treatment of relapsed/refractory acute myeloid leukemia in children].
Klinische Pädiatrie 2002;214(4):188-94.
2002: Dirk Reinhardt; Claudia Langebrake; Ursula Creutzig; Josef Vormoor; C Brune; M Thorwesten; P Ingiliz; Ondrej Hrusak; Michael Dworzak; Frank Griesinger
[Minimal residual disease in acute myeloid leukemia in children--standardization and evaluation of immunophenotyping in the AML-BFM-98 study].
Klinische Pädiatrie 2002;214(4):179-87.
2002: B Selle; C Bär; S Hecker; U Schmidt-Rohr; S Viehmann; K-M Debatin; Dirk Reinhardt
ABL-specific tyrosine kinase inhibitor imatinib as salvage therapy in a child with Philadelphia chromosome-positive acute mixed lineage leukemia (AMLL).
Leukemia 2002;16(7):1393-5.
2002: Dirk Reinhardt; U Creutzig
Isolated myelosarcoma in children--update and review.
Leukemia & lymphoma 2002;43(3):565-74.
2002: Claudia Langebrake; Dirk Reinhardt; Jörg Ritter
Minimising the long-term adverse effects of childhood leukaemia therapy.
Drug safety : an international journal of medical toxicology and drug experience 2002;25(15):1057-77.
2002: Dirk Reinhardt; C Thiele; Ursula Creutzig
[Neuropsychological sequelae in children with AML treated with or without prophylactic CNS-irradiation].
Klinische Pädiatrie 2002;214(1):22-9.
2001: Dirk Reinhardt; R Ridder; Wilfried Kugler; Arnulf Pekrun
Post-transcriptional effects of interleukin-3, interferon-gamma, erythropoietin and butyrate on in vitro hemoglobin chain synthesis in congenital hemolytic anemia.
Haematologica 2001;86(8):791-800.
2001: G Mann; Dirk Reinhardt; J Ritter; J Hermann; K Schmitt; Helmut Gadner; U Creutzig
Treatment with all-trans retinoic acid in acute promyelocytic leukemia reduces early deaths in children.
Annals of hematology 2001;80(7):417-22.
2001: Ursula Creutzig; F Berthold; Joachim Boos; G Fleischhack; H Gadner; A Gnekow; Ulrike B Graubner; G Henze; Johann Hermann; P Imbach; Heribert Jürgens; Hartmut Kabisch; Dieter Körholz; Charlotte M Niemeyer; Dirk Reinhardt; Alfred Reiter; Jörg Ritter; Hans J Spaar; Martin Zimmermann
[Improved treatment results in children with AML: Results of study AML-BFM 93].
Klinische Pädiatrie 2001;213(4):175-85.
2001: U Creutzig; Dirk Reinhardt; M Zimmermann; T Klingebiel; H Gadner
Intensive chemotherapy versus bone marrow transplantation in pediatric acute myeloid leukemia: a matter of controversies.
Blood 2001;97(11):3671-2; author reply 3674-5.
2001: Ursula Creutzig; J Ritter; Martin Zimmermann; Dirk Reinhardt; J Hermann; F Berthold; Günter Henze; Heribert Jürgens; H Kabisch; Werner Havers; Alfred Reiter; U Kluba; F Niggli; H Gadner
Improved treatment results in high-risk pediatric acute myeloid leukemia patients after intensification with high-dose cytarabine and mitoxantrone: results of Study Acute Myeloid Leukemia-Berlin-Frankfurt-Münster 93.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(10):2705-13.
2001: Dirk Reinhardt; Olaf Witt; Nicolai Miosge; Rainer Herken; Arnulf Pekrun
Increase in band 3 density and aggregation in hereditary spherocytosis.
Blood cells, molecules & diseases 2001;27(2):399-406.
2000: Dirk Reinhardt; Arnulf Pekrun; Max Lakomek; M Zimmermann; J Ritter; U Creutzig
Primary myelosarcomas are associated with a high rate of relapse: report on 34 children from the acute myeloid leukaemia-Berlin-Frankfurt-Münster studies.
British journal of haematology 2000;110(4):863-6.
2000: Dirk Reinhardt; Julianne Behnke-Mursch; Elisabeth Weiss; HJ Christen; J Kühl; Max Lakomek; Arnulf Pekrun
Rhabdoid tumors of the central nervous system.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2000;16(4):228-34.
2000: Dirk Reinhardt; Holger H Sigusch; SF Vogt; C Zeiss; Katrin Farker; Annemarie Hoffmann; S Müller
A common variant of the angiotensinogen gene and the risk of coronary artery disease in a German population.
Die Pharmazie 2000;55(1):69-71.
1999: A Iglauer; Dirk Reinhardt; W Schröter; Arnulf Pekrun
Cryohemolysis test as a diagnostic tool for hereditary spherocytosis.
Annals of hematology 1999;78(12):555-7.
1999: Stefan W Eber; C M Langendörfer; M Ditzig; Dirk Reinhardt; G Stöhr; W Soldan; W Schröter; G Tchernia
Frequency of very late fatal sepsis after splenectomy for hereditary spherocytosis: impact of insufficient antibody response to pneumococcal infection.
Annals of hematology 1999;78(11):524-8.
1999: Dirk Reinhardt; Arnulf Pekrun; Max Lakomek; J Ritter; U Creutzig
[Primary isolated myeolosarcoma in childhood].
Klinische Pädiatrie 1999;211(4):245-9.
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