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Nils Billestrup

Research Profile

Chemicals & Drugs

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TOP 3
T N Haase; C A M Jaksch; Nils Billestrup; Louise Winkel Gaarn; C K Petersen; M Rasmussen; Jens H Nielsen
Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.
Jakob Bondo Hansen; R Scott Heller; Birgitte Holst; Allan E Karlsen; Andreas Nygaard Madsen; Anja Østergren Nielsen; Flemming Pociot; Klaus Qvortrup; Joachim Størling; Morten Fog Tonnesen; Mogens Aalund; Nancy C Andrews; Leeat Anker-Kitai; Luc Baeyens; Nils Billestrup; Luc Bouwens; Shimon Efrat; Josefine Friberg; Lars Groth Grunnet; Peter H Hagedorn; Thomas Mandrup-Poulsen
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Nils Billestrup
ID'ing a novel inhibitor of β-cell function, Id1.

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2013: T N Haase; C A M Jaksch; Nils Billestrup; Louise Winkel Gaarn; C K Petersen; M Rasmussen; Jens H Nielsen
Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell.
Diabetologia 2013;56(4):763-73.
2012: Jakob Bondo Hansen; R Scott Heller; Birgitte Holst; Allan E Karlsen; Andreas Nygaard Madsen; Anja Østergren Nielsen; Flemming Pociot; Klaus Qvortrup; Joachim Størling; Morten Fog Tonnesen; Mogens Aalund; Nancy C Andrews; Leeat Anker-Kitai; Luc Baeyens; Nils Billestrup; Luc Bouwens; Shimon Efrat; Josefine Friberg; Lars Groth Grunnet; Peter H Hagedorn; Thomas Mandrup-Poulsen
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Cell metabolism 2012;16(4):449-61.
2011: Nils Billestrup
ID'ing a novel inhibitor of β-cell function, Id1.
Diabetes 2011;60(10):2455-6.
2011: Dan P Christensen; Mattias Dahllöf; Lars G Grunnet; Morten Lundh; Mette D Nielsen; Daniel Noesgaard; Nils Billestrup; Thomas Mandrup-Poulsen
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):378-90.
2011: Nikolaj Kulahin; Lars Groth Grunnet; Morten Lundh; Dan Ploug Christensen; Rasmus Jorgensen; Anders Heding; Nils Billestrup; Vladimir Berezin; Elisabeth Bock; Thomas Mandrup-Poulsen
Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique.
FEBS letters 2011;585(1):58-64.
2011: Henrik Reinhard; Lise Tarnow; Anne Sofie Astrup; Nils Billestrup; Peter Karl Jacobsen; Won Yong Kim; Maria Lajer; Thomas Mandrup-Poulsen; Hans-Henrik Parving; Nadja Pedersen; Peter Rossing
Endothelial progenitor cells in long-standing asymptomatic type 1 diabetic patients with or without diabetic nephropathy.
Nephron. Clinical practice 2011;118(3):c309-14.
2010: M Lundh; D P Christensen; Daniel Noesgaard; P Mascagni; C A Dinarello; Nils Billestrup; L G Grunnet; Thomas Mandrup-Poulsen
Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines.
Diabetologia 2010;53(12):2569-78.
2010: Karsten Wessel Eriksen; Anders Woetmann; Lone Skov; Thorbjørn Krejsgaard; Lone F Bovin; Mikkel L Hansen; Kirsten Grønbaek; Nils Billestrup; Mogens H Nissen; Carsten Geisler; Mariusz A Wasik; Niels Ødum
Deficient SOCS3 and SHP-1 expression in psoriatic T cells.
The Journal of investigative dermatology 2010;130(6):1590-7.
2010: Mark Huising; Talitha van der Meulen; Joan M Vaughan; Masahito Max Matsumoto; Cynthia J Donaldson; Hannah Park; Nils Billestrup; Wylie W Vale
CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):912-7.
2010: Martin Friedrichsen; Rasmus Ribel-Madsen; Jørgen Wojtaszewski; Louise Grunnet; Erik A Richter; Nils Billestrup; Thorkil Ploug; Allan Vaag; Pernille Poulsen
Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins.
The Journal of clinical endocrinology and metabolism 2010;95(1):414-21.
2009: Christine Bruun; Peter E Heding; Sif G Rønn; Helle Frobøse; Christopher J Rhodes; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Molecular and cellular endocrinology 2009;311(1-2):32-8.
2009: Morten F Tonnesen; Lars G Grunnet; Josefine Friberg; Alessandra K Cardozo; Nils Billestrup; Décio L Eizirik; Joachim Størling; Thomas Mandrup-Poulsen
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
Endocrinology 2009;150(9):4094-103.
2009: Patrick Collombat; Xiaobo Xu; Philippe Ravassard; Beatriz Sosa-Pineda; Sébastien Dussaud; Nils Billestrup; Ole D Madsen; Palle Serup; Harry Heimberg; Ahmed Mansouri
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.
Cell 2009;138(3):449-62.
2009: Lars G Grunnet; Reid Aikin; Morten F Tonnesen; Steven Paraskevas; Lykke Blaabjerg; Joachim Størling; Lawrence Rosenberg; Nils Billestrup; Dusica Maysinger; Thomas Mandrup-Poulsen
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.
Diabetes 2009;58(8):1807-15.
2009: Louise Moller; Lisa Dalman; Helene Norrelund; Nils Billestrup; Jan Frystyk; Niels Moller; Jens Otto Lunde Jorgensen
Impact of fasting on growth hormone signaling and action in muscle and fat.
The Journal of clinical endocrinology and metabolism 2009;94(3):965-72.
2009: M L B Jacobsen; S G Rønn; C Bruun; C M Larsen; D L Eizirik; T Mandrup-Poulsen; Nils Billestrup
IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.
Diabetologia 2009;52(2):281-8.
2008: S G Rønn; A Börjesson; C Bruun; P E Heding; H Frobøse; T Mandrup-Poulsen; A E Karlsen; J Rasschaert; S Sandler; Nils Billestrup
Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.
Diabetologia 2008;51(10):1873-82.
2008: Nils Billestrup; Timo Otonkoski
Dedifferentiation for replication of human beta-cells: a division between mice and men?
Diabetes 2008;57(6):1457-8.
2008: Marc Y Donath; Joachim Størling; Lukas A Berchtold; Nils Billestrup; Thomas Mandrup-Poulsen
Cytokines and beta-cell biology: from concept to clinical translation.
Endocrine reviews 2008;29(3):334-50.
2008: Géraldine Parnaud; Domenico Bosco; Thierry Berney; F Pattou; J Kerr-Conte; Marc Y Donath; C Bruun; Thomas Mandrup-Poulsen; Nils Billestrup; Philippe A Halban
Proliferation of sorted human and rat beta cells.
Diabetologia 2008;51(1):91-100.
2007: L Larsen; Morten Tonnesen; S G Ronn; Joachim Størling; S Jørgensen; P Mascagni; C A Dinarello; Nils Billestrup; Thomas Mandrup-Poulsen
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells.
Diabetologia 2007;50(4):779-89.
2007: Jens Otto Lunde Jørgensen; Louise Møller; Morten Krag; Nils Billestrup; Jens Sandahl Christiansen
Effects of growth hormone on glucose and fat metabolism in human subjects.
Endocrinology and metabolism clinics of North America 2007;36(1):75-87.
2007: Sif G Rønn; Nils Billestrup; Thomas Mandrup-Poulsen
Diabetes and suppressors of cytokine signaling proteins.
Diabetes 2007;56(2):541-8.
2006: Jens Otto Lunde Jørgensen; Niels Jessen; Steen Pedersen; Esben Thyssen Vestergaard; Lars C Gormsen; Sten A Lund; Nils Billestrup
GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E899-905.
2006: L G Petersen; Joachim Størling; Peter E Heding; S Li; V Berezin; J Saldeen; Nils Billestrup; E Bock; Thomas Mandrup-Poulsen
IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.
Diabetologia 2006;49(8):1864-75.
2006: Helle Frobøse; Sif G Rønn; Peter E Heding; Heidi Mendoza; Philip Cohen; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1587-96.
2006: Claus Morten Larsen; Morten Graugaard Døssing; S Papa; G Franzoso; Nils Billestrup; Thomas Mandrup-Poulsen
Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells.
Diabetologia 2006;49(5):980-9.
2005: L Larsen; Joachim Størling; Martine I Darville; Decio L Eizirik; Christophe Bonny; Nils Billestrup; Thomas Mandrup-Poulsen
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Karen Lindberg; Sif G Rønn; D Tornehave; H Richter; Johnny A Hansen; J Rømer; M Jackerott; Nils Billestrup
Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.
Journal of molecular endocrinology 2005;35(2):231-43.
2005: Joachim Størling; J Binzer; Annika K Andersson; R A Züllig; Morten Tonnesen; R Lehmann; Giatgen A Spinas; Stellan Sandler; Nils Billestrup; Thomas Mandrup-Poulsen
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.
Diabetologia 2005;48(10):2039-50.
2005: Joachim Størling; Sergei V Zaitsev; Iouri L Kapelioukh; Allan E Karlsen; Nils Billestrup; Per-Olof Berggren; Thomas Mandrup-Poulsen
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Endocrinology 2005;146(7):3026-36.
2005: Ida Katrine Lund; J A Hansen; Henrik Sune Andersen; N P H Møller; Nils Billestrup
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling.
Journal of molecular endocrinology 2005;34(2):339-51.
2005: Joachim Størling; Nathalie Allaman-Pillet; Allan E Karlsen; Nils Billestrup; Christophe Bonny; Thomas Mandrup-Poulsen
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Endocrinology 2005;146(4):1718-26.
2004: Allan E Karlsen; Peter E Heding; H Frobøse; Sif G Rønn; Mogens Kruhøffer; T F Orntoft; Martine I Darville; Decio L Eizirik; Flemming Pociot; Jørn Nerup; Thomas Mandrup-Poulsen; Nils Billestrup
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Diabetologia 2004;47(11):1998-2011.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Lene R Clausen; Mikkel T Kristiansen; Lars Melholt Rasmussen; Nils Billestrup; Ole Blaabjerg; Thomas Ledet; Jens Otto Lunde Jørgensen
Growth hormone receptor expression and function in pituitary adenomas.
Clinical endocrinology 2004;60(5):576-83.
2003: Hichem C Mertani; Mireille Raccurt; Aude Abbate; Jon Kindblom; Jan Törnell; Nils Billestrup; Yves Usson; Gérard Morel; Peter E Lobie
Nuclear translocation and retention of growth hormone.
Endocrinology 2003;144(7):3182-95.
2003: Birgitte N Friedrichsen; Henrijette E Richter; Johnny A Hansen; Christopher J Rhodes; Jens H Nielsen; Nils Billestrup; Annette Møldrup
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):945-58.
2003: H E Richter; Tatjana Albrektsen; Nils Billestrup
The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation.
Journal of molecular endocrinology 2003;30(2):139-50.
2003: Martin Ridderstråle; J Amstrup; D J Hilton; Nils Billestrup; Hans Tornqvist
SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(3):169-77.
2002: Christopher J Greenhalgh; Donald Metcalf; Anne L Thaus; Jason E Corbin; Rachel Uren; Phillip O Morgan; Louis J Fabri; Jian-Guo Zhang; Helene M Martin; Tracy A Willson; Nils Billestrup; Nicos A Nicola; Manuel Baca; Warren S Alexander; Douglas J Hilton
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
The Journal of biological chemistry 2002;277(43):40181-4.
2002: Sif G Rønn; Johnny A Hansen; Karen Lindberg; Allan E Karlsen; Nils Billestrup
The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2124-34.
2001: Allan E Karlsen; Sif G Rønn; Karen Lindberg; Jesper Johannesen; Elisabeth D Galsgaard; Flemming Pociot; Jens H Nielsen; Thomas Mandrup-Poulsen; Jørn Nerup; Nils Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12191-6.
2001: Christine Brender; Morten Nielsen; Keld Kaltoft; Gerd Just Mikkelsen; Qian Zhang; Mariusz A Wasik; Nils Billestrup; Niels Odum
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
Blood 2001;97(4):1056-62.
2001: Jens H Nielsen; Elisabeth D Galsgaard; Annette Møldrup; Birgitte N Friedrichsen; Nils Billestrup; J A Hansen; Ying C Lee; C Carlsson
Regulation of beta-cell mass by hormones and growth factors.
Diabetes 2001;50 Suppl 1():S25-9.
2001: Christine Brender; Morten Nielsen; Carsten Röpke; Mogens H Nissen; Arne Svejgaard; Nils Billestrup; Carsten Geisler; Niels Ødum
Interferon-alpha induces transient suppressors of cytokine signalling expression in human T cells.
Experimental and clinical immunogenetics 2001;18(2):80-5.
2000: MR Stofega; James Herrington; Nils Billestrup; Christin Carter-Su
Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.
Molecular endocrinology (Baltimore, Md.) 2000;14(9):1338-50.
2000: SN Behncken; Nils Billestrup; Richard Brown; J Amstrup; Becky L Conway-Campbell; Michael J Waters
Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation.
The Journal of biological chemistry 2000;275(22):17000-7.
1999: Johnny A Hansen; Karen Lindberg; D J Hilton; Jens H Nielsen; Nils Billestrup
Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins.
Molecular endocrinology (Baltimore, Md.) 1999;13(11):1832-43.
1999: Y C Lee; AB Damholt; Nils Billestrup; T Kisbye; P Galante; Birgitte K Michelsen; Hans Kofod; Jens H Nielsen
Developmental expression of proprotein convertase 1/3 in the rat.
Molecular and cellular endocrinology 1999;155(1-2):27-35.
1999: Jens H Nielsen; C Svensson; Elisabeth D Galsgaard; Annette Møldrup; Nils Billestrup
Beta cell proliferation and growth factors.
Journal of molecular medicine (Berlin, Germany) 1999;77(1):62-6.
1998: LH Hansen; B Madsen; Børge Teisner; Jens H Nielsen; Nils Billestrup
Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation.
Molecular endocrinology (Baltimore, Md.) 1998;12(8):1140-9.
1998: Nils Billestrup; Johnny A Hansen; LH Hansen; Annette Møldrup; Elisabeth D Galsgaard; Jens H Nielsen
Molecular mechanism of growth hormone signalling.
Endocrine journal 1998;45 Suppl():S41-5.
1998: Tzy-Wen L Gong; D J Meyer; J Liao; Christina L Hodge; GS Campbell; X Wang; Nils Billestrup; Christin Carter-Su; Jessica Schwartz
Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors.
Endocrinology 1998;139(4):1863-71.
1998: T E Adams; J A Hansen; Robyn Starr; Nicos A Nicola; Douglas J Hilton; Nils Billestrup
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling.
The Journal of biological chemistry 1998;273(3):1285-7.
1997: C Carlsson; D Tornehave; Karen Lindberg; P Galante; Nils Billestrup; Birgitte K Michelsen; Lars-Inge Larsson; Jens H Nielsen
Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas.
Endocrinology 1997;138(9):3940-8.
1997: Johnny A Hansen; LH Hansen; X Wang; J J Kopchick; Fabrice Gouilleux; Bernd Groner; Jens H Nielsen; Annette Møldrup; Elisabeth D Galsgaard; Nils Billestrup
The role of GH receptor tyrosine phosphorylation in Stat5 activation.
Journal of molecular endocrinology 1997;18(3):213-21.
1996: Lawrence S Argetsinger; Gunnar Norstedt; Nils Billestrup; M F White; Christin Carter-Su
Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling.
The Journal of biological chemistry 1996;271(46):29415-21.
1996: Anthony King; M J Tseng; Craig D Logsdon; Nils Billestrup; Christin Carter-Su
Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization.
The Journal of biological chemistry 1996;271(30):18088-94.
1996: Elisabeth D Galsgaard; F Gouilleux; B Groner; Palle Serup; Jens H Nielsen; Nils Billestrup
Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.
Molecular endocrinology (Baltimore, Md.) 1996;10(6):652-60.
1996: L H Hansen; X Wang; J J Kopchick; P Bouchelouche; Jens H Nielsen; Elisabeth D Galsgaard; Nils Billestrup
Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation.
The Journal of biological chemistry 1996;271(21):12669-73.
1996: L S Smit; D J Meyer; Nils Billestrup; Gunnar Norstedt; Jessica Schwartz; Christin Carter-Su
The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.
Molecular endocrinology (Baltimore, Md.) 1996;10(5):519-33.
1995: Peter E Lobie; G Allevato; Jens H Nielsen; Gunnar Norstedt; Nils Billestrup
Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function.
The Journal of biological chemistry 1995;270(37):21745-50.
1995: J A VanderKuur; X Wang; Lizhi Zhang; G Allevato; Nils Billestrup; Christin Carter-Su
Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor.
The Journal of biological chemistry 1995;270(37):21738-44.
1995: Jens H Nielsen; Nils Billestrup; G Allevato; Annette Møldrup; E D Petersen; J Amstrup; Johnny A Hansen; C Svensson
Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways.
Annals of the New York Academy of Sciences 1995;766():481-3.
1995: G Allevato; Nils Billestrup; L Goujon; Elisabeth D Galsgaard; Gunnar Norstedt; Marie Catherine Postel-Vinay; Paul A Kelly; Jens H Nielsen
Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation.
The Journal of biological chemistry 1995;270(29):17210-4.
1995: Lawrence S Argetsinger; G W Hsu; Martin G Myers Jr; Nils Billestrup; M F White; Christin Carter-Su
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.
The Journal of biological chemistry 1995;270(24):14685-92.
1995: J VanderKuur; G Allevato; Nils Billestrup; Gunnar Norstedt; Christin Carter-Su
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
The Journal of biological chemistry 1995;270(13):7587-93.
1995: Nils Billestrup; P Bouchelouche; G Allevato; M Ilondo; Jens H Nielsen
Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2725-9.
1994: Peter E Lobie; Timothy J J Wood; D Sliva; Nils Billestrup; M J Waters; B Enberg; Gunnar Norstedt
The cellular mechanism of growth hormone signal transduction.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1994;406():39-46; discussion 47.
1994: J A VanderKuur; X Wang; Lizhi Zhang; G S Campbell; G Allevato; Nils Billestrup; Gunnar Norstedt; Christin Carter-Su
Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.
The Journal of biological chemistry 1994;269(34):21709-17.
1994: Nils Billestrup; G Allevato; Gunnar Norstedt; Annette Møldrup; Jens H Nielsen
Identification of intracellular domains in the growth hormone receptor involved in signal transduction.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):205-9.
1994: Gunnar Norstedt; B Enberg; S Francis; A Hansson; A Hulthén; Peter E Lobie; D Sliva; Timothy J J Wood; Nils Billestrup
Cell transfection as a tool to study growth hormone action.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):181-4.
1993: Jens H Nielsen; Nils Billestrup; Annette Møldrup; G Allevato; E D Petersen; J A Pedersen; Johnny A Hansen
Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors.
Biochemical Society transactions 1993;21(1):146-9.
1992: Sylvia Asa; K Kovacs; L Stefaneanu; Eva Horvath; Nils Billestrup; C Gonzalez-Manchon; W Vale
Pituitary adenomas in mice transgenic for growth hormone-releasing hormone.
Endocrinology 1992;131(5):2083-9.
1992: X Wang; Michael D Uhler; Nils Billestrup; Gunnar Norstedt; F Talamantes; Jens H Nielsen; Christin Carter-Su
Evidence for association of the cloned liver growth hormone receptor with a tyrosine kinase.
The Journal of biological chemistry 1992;267(24):17390-6.
1992: Jens H Nielsen; Annette Møldrup; Nils Billestrup; E D Petersen; G Allevato; M Stahl
The role of growth hormone and prolactin in beta cell growth and regeneration.
Advances in experimental medicine and biology 1992;321():9-17; discussion 19-20.
1991: Annette Møldrup; G Allevato; Thomas Dyrberg; Jens H Nielsen; Nils Billestrup
Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors.
The Journal of biological chemistry 1991;266(26):17441-5.
1991: Nils Billestrup; Jens H Nielsen
The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I.
Endocrinology 1991;129(2):883-8.
1990: Nils Billestrup; Annette Møldrup; Palle Serup; L S Mathews; Gunnar Norstedt; Jens H Nielsen
Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):7210-4.
1990: Annette Møldrup; Nils Billestrup; Jens H Nielsen
Rat insulinoma cells express both a 115-kDa growth hormone receptor and a 95-kDa prolactin receptor structurally related to the hepatic receptors.
The Journal of biological chemistry 1990;265(15):8686-90.
1990: Sylvia Asa; K Kovacs; L Stefaneanu; Eva Horvath; Nils Billestrup; C Gonzalez-Manchon; W Vale
Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1990;193(3):232-5.
1990: Nils Billestrup; C González-Manchón; E Potter; Wylie Vale
Inhibition of somatotroph growth and growth hormone biosynthesis by activin in vitro.
Molecular endocrinology (Baltimore, Md.) 1990;4(2):356-62.
1990: E D Petersen; Nils Billestrup; Jens H Nielsen
Effect of growth hormone and serum on the expression of the proto-oncogenes c-jun and c-fos in insulin producing cells.
Biomedica biochimica acta 1990;49(12):1171-5.
1990: Jens H Nielsen; Annette Møldrup; Nils Billestrup
Expression of the growth hormone receptor gene in insulin producing cells.
Biomedica biochimica acta 1990;49(12):1151-5.
1989: L Stefaneanu; K Kovacs; Eva Horvath; Sylvia Asa; N E Losinski; Nils Billestrup; J Price; W Vale
Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation.
Endocrinology 1989;125(5):2710-8.
1989: Annette Møldrup; Nils Billestrup; N A Thorn; Ake Lernmark; Jens H Nielsen
Multiple growth hormone-binding proteins are expressed on insulin-producing cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1173-82.
1989: Jens H Nielsen; S Linde; B S Welinder; Nils Billestrup; Ole D Madsen
Growth hormone is a growth factor for the differentiated pancreatic beta-cell.
Molecular endocrinology (Baltimore, Md.) 1989;3(1):165-73.
1987: E Nishimura; Nils Billestrup; M Perrin; Wylie Vale
Identification and characterization of a pituitary corticotropin-releasing factor binding protein by chemical cross-linking.
The Journal of biological chemistry 1987;262(27):12893-6.
1987: Nils Billestrup; R L Mitchell; Wylie Vale; Inder M Verma
Growth hormone-releasing factor induces c-fos expression in cultured primary pituitary cells.
Molecular endocrinology (Baltimore, Md.) 1987;1(4):300-5.
1986: Jessica Schwartz; Nils Billestrup; M Perrin; J Rivier; W Vale
Identification of corticotropin-releasing factor (CRF) target cells and effects of dexamethasone on binding in anterior pituitary using a fluorescent analog of CRF.
Endocrinology 1986;119(5):2376-82.
1986: Nils Billestrup; L W Swanson; W Vale
Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6854-7.
1985: Nils Billestrup; J M Martin
Growth hormone binding to specific receptors stimulates growth and function of cloned insulin-producing rat insulinoma RIN-5AH cells.
Endocrinology 1985;116(3):1175-81.
1985: Nils Billestrup
Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells.
Biomedica biochimica acta 1985;44(1):85-7.
1984: Thomas Dyrberg; Nils Billestrup
Preparation of 125I-protein A usable for up to 10 months in immunoassays.
Journal of immunological methods 1984;71(2):193-201.