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Amanda McClerren

Research Profile

Chemicals & Drugs

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Nuclear Magnetic Resonance, Biomolecular

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Publications

TOP 3
M Violet Lee; Leigh Anne Furgerson Ihnken; Young Ok You; Amanda McClerren; Wilfred Adrianus van der Donk; Neil L Kelleher
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.
Lisa E Cooper; Amanda McClerren; Anita Chary; Wilfred Adrianus van der Donk
Structure-activity relationship studies of the two-component lantibiotic haloduracin.
Adam W Barb; Amanda McClerren; Karnem Snehelatha; C Michael Reynolds; Pei Zhou; Christian R H Raetz
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.

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All Publications

2009: M Violet Lee; Leigh Anne Furgerson Ihnken; Young Ok You; Amanda McClerren; Wilfred Adrianus van der Donk; Neil L Kelleher
Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.
Journal of the American Chemical Society 2009;131(34):12258-64.
2008: Lisa E Cooper; Amanda McClerren; Anita Chary; Wilfred Adrianus van der Donk
Structure-activity relationship studies of the two-component lantibiotic haloduracin.
Chemistry & biology 2008;15(10):1035-45.
2007: Adam W Barb; Amanda McClerren; Karnem Snehelatha; C Michael Reynolds; Pei Zhou; Christian R H Raetz
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
Biochemistry 2007;46(12):3793-802.
2006: Amanda McClerren; Lisa E Cooper; Chao Quan; Paul M Thomas; Neil L Kelleher; Wilfred Adrianus van der Donk
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17243-8.
2006: Khisimuzi Mdluli; Pamela R Witte; Toni Kline; Adam W Barb; Alice L Erwin; Bryce E Mansfield; Amanda McClerren; Michael C Pirrung; L Nathan Tumey; Paul Warrener; Christian R H Raetz; C Kendall Stover
Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2006;50(6):2178-84.
2005: Amanda McClerren; Stephanie Endsley; Jason L Bowman; Niels H Andersen; Ziqiang Guan; Johannes Rudolph; Christian R H Raetz
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
Biochemistry 2005;44(50):16574-83.
2005: Steven D Breazeale; Anthony A Ribeiro; Amanda McClerren; Christian R H Raetz
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
The Journal of biological chemistry 2005;280(14):14154-67.
2005: Brian E Coggins; Amanda McClerren; Ling Jiang; Xuechen Li; Johannes Rudolph; Ole Hindsgaul; Christian R H Raetz; Pei Zhou
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
Biochemistry 2005;44(4):1114-26.
2005: Amanda McClerren; Pei Zhou; Ziqiang Guan; Christian R H Raetz; Johannes Rudolph
Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
Biochemistry 2005;44(4):1106-13.
2003: Brian E Coggins; Xuechen Li; Amanda McClerren; Ole Hindsgaul; Christian R H Raetz; Pei Zhou
Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
Nature structural biology 2003;10(8):645-51.
2003: Michael C Pirrung; L Nathan Tumey; Amanda McClerren; Christian R H Raetz
High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties.
Journal of the American Chemical Society 2003;125(6):1575-86.
2002: Michael C Pirrung; L Nathan Tumey; Christian R H Raetz; Jane E Jackman; Karnem Snehalatha; Amanda McClerren; Carol A Fierke; Stephanie L Gantt; Kristin M Rusche
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.
Journal of medicinal chemistry 2002;45(19):4359-70.