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Isabelle Hubeek

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Disorders

Procedures

Drug Screening Assays, Antitumor

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Publications

TOP 3
Mahban Irandoust; G J L Kaspers; Pamela Kearns; Dirk Reinhardt; Karin Schornagel; Edwin Sonneveld; Peter J Valk; Ellen M van Beek; Arjan A van de Loosdrecht; Mercan Akyuz; Julian Alvarez Zarate; A J F Broekhuizen; Jacqueline Cloos; Eva A Coenen; Ursula Creutzig; Eveline S J M de Bont; Ruud Delwel; Isabelle Hubeek; Marry M van den Heuvel-Eibrink; Christian M Zwaan; Timo K van den Berg
Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
Isabelle Hubeek; Alferso C Abrahams; Michiel de Bruin; Hans Kemperman
Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®).
Godefridus J Peters; J Hodzic; B Ortega; Elisa Giovannetti; Auke D Adema; Richard Broekhuizen; G J L Kaspers; Isabelle Hubeek
Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase.

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All Publications

2013: Mahban Irandoust; G J L Kaspers; Pamela Kearns; Dirk Reinhardt; Karin Schornagel; Edwin Sonneveld; Peter J Valk; Ellen M van Beek; Arjan A van de Loosdrecht; Mercan Akyuz; Julian Alvarez Zarate; A J F Broekhuizen; Jacqueline Cloos; Eva A Coenen; Ursula Creutzig; Eveline S J M de Bont; Ruud Delwel; Isabelle Hubeek; Marry M van den Heuvel-Eibrink; Christian M Zwaan; Timo K van den Berg
Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
PloS one 2013;8(1):e52143.
2012: Isabelle Hubeek; Alferso C Abrahams; Michiel de Bruin; Hans Kemperman
Falsely decreased ionized calcium results due to analytical interference by teriflunomide, the active metabolite of leflunomide (Arava®).
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(4):755-6.
2010: Godefridus J Peters; J Hodzic; B Ortega; Elisa Giovannetti; Auke D Adema; Richard Broekhuizen; G J L Kaspers; Isabelle Hubeek
Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):408-13.
2008: Isabelle Hubeek; Elisa Giovannetti; A J F Broekhuizen; M Pastor-Anglada; G J L Kaspers; Godefridus J Peters
Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.
Nucleosides, nucleotides & nucleic acids 2008;27(6):787-93.
2008: Isabelle Hubeek; Elizabeth M Comijn; Clasina L Van der Wilt; Ronald L Merriman; Jose Padron; G J L Kaspers; Godefridus J Peters
CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo.
Oncology reports 2008;19(6):1517-23.
2006: Auke D Adema; L Zuurbier; Karijn Floor; Isabelle Hubeek; G J L Kaspers; F Albertoni; Godefridus J Peters
Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):981-6.
2006: Isabelle Hubeek; Godefridus J Peters; Richard Broekhuizen; Christian M Zwaan; Patricia Kaaijk; Elisabeth S van Wering; Brenda E S Gibson; Ursula Creutzig; Gritta E Janka-Schaub; Monique L den Boer; Rob Pieters; G J L Kaspers
In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia.
Haematologica 2006;91(1):17-23.
2006: Ronald W Stam; Isabelle Hubeek; Monique L den Boer; J G C A M Buijs-Gladdines; Ursula Creutzig; G J L Kaspers; Rob Pieters
MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia.
Leukemia 2006;20(1):179-82.
2005: Isabelle Hubeek; Ronald W Stam; Godefridus J Peters; Richard Broekhuizen; Jules P P Meijerink; Elisabeth R van Wering; Brenda E S Gibson; Ursula Creutzig; Christian M Zwaan; Jacqueline Cloos; Dirk J Kuik; Rob Pieters; G J L Kaspers
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia.
British journal of cancer 2005;93(12):1388-94.
2005: André Bergman; Paul P Eijk; Veronique Ruiz van Haperen; Kees Smid; Gijsbert Veerman; Isabelle Hubeek; Paul van den IJssel; Bauke Ylstra; Godefridus J Peters
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.
Cancer research 2005;65(20):9510-6.
2005: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; J Sargent; Brenda E S Gibson; Ursula Creutzig; G J L Kaspers
Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia.
British journal of haematology 2005;131(2):219-22.
2005: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; Iannis Talianidis; Jennifer Sigmond; Brenda E S Gibson; Ursula Creutzig; G Giaccone; G J L Kaspers
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours.
Journal of clinical pathology 2005;58(7):695-9.
2004: Isabelle Hubeek; Elena Litvinova; Godefridus J Peters; Richard Broekhuizen; Eric G Haarman; Dieuwke R Huismans; Jacqueline Cloos; Christian M Zwaan; Gudrun Fleischhack; Ursula Creutzig; G J L Kaspers
The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia.
International journal of oncology 2004;25(6):1823-9.
2004: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; G J L Kaspers
Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1513-6.
2004: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; Iannis Talianidis; Antoinette Y N Schouten-Van Meeteren; Elisabeth R van Wering; B Gibson; Ursula Creutzig; G J L Kaspers
Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1351-6.
2003: Jean M Sargent; Christine J Williamson; Isabelle Hubeek; Alena W Elgie; Colin G Taylor; Monique L den Boer; Godefridus J Peters; Gertjan L Kaspers
Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia.
Oncology reports 2003;10(6):2027-31.
2001: Isabelle Hubeek; NL Ramakers-van Woerden; Rob Pieters; Rosalyn Slater; Berna Beverloo; Elisabeth R van Wering; Willem A Kamps; Karel Hählen; Anjo J P Veerman
TEL/AML1 fusion is not a prognostic factor in Dutch childhood acute lymphoblastic leukaemia.
British journal of haematology 2001;113(1):254-5.
2000: NL Ramakers-van Woerden; Rob Pieters; Anne H Loonen; Isabelle Hubeek; Ellen van Drunen; Berna Beverloo; Rosalyn M Slater; Jochen Harbott; Jeanette Seyfarth; Elisabeth R van Wering; Karel Hählen; Kjeld Schmiegelow; Gritta E Janka-Schaub; Anjo J P Veerman
TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.
Blood 2000;96(3):1094-9.