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Alejandro Buschiazzo

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Amino Acid Sequences

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Publications

TOP 3
Agustin Correa; Guillermo Dighiero; Gonzalo Obal; Pablo Oppezzo; Otto Pritsch; Felipe Trajtenberg; Alejandro Buschiazzo
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
Daniela Albanesi; Alejandro Buschiazzo; Diego de Mendoza; Michel Debarbouille; Marcelo E Guerin; Georgina Reh; Francis Schaeffer; Gustavo Schujman; Pedro Alzari
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.
Sofía Horjales; Olivier Leclercq; Ramiro Rodriguez Limardo; Gonzalo Obal; Eric Prina; Dirk Schmidt-Arras; GF Späth; Adrian G Turjanski; Alejandro Buschiazzo
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.

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All Publications

2013: Agustin Correa; Guillermo Dighiero; Gonzalo Obal; Pablo Oppezzo; Otto Pritsch; Felipe Trajtenberg; Alejandro Buschiazzo
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
Acta crystallographica. Section D, Biological crystallography 2013;69(Pt 3):388-97.
2013: Daniela Albanesi; Alejandro Buschiazzo; Diego de Mendoza; Michel Debarbouille; Marcelo E Guerin; Georgina Reh; Francis Schaeffer; Gustavo Schujman; Pedro Alzari
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.
PLoS pathogens 2013;9(1):e1003108.
2012: Sofía Horjales; Olivier Leclercq; Ramiro Rodriguez Limardo; Gonzalo Obal; Eric Prina; Dirk Schmidt-Arras; GF Späth; Adrian G Turjanski; Alejandro Buschiazzo
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Structure (London, England : 1993) 2012;20(10):1649-60.
2011: Cecilia Ortíz; Horacio Botti; Marcelo Comini; Nicole Larrieux; Andrea Medeiros; Alejandro Buschiazzo
Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 11):1457-61.
2011: Pablo Oppezzo; Otto Pritsch; Pedro Alzari; Martín Baraibar; Gonzalo Obal; Alejandro Buschiazzo
Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity.
Biochimica et biophysica acta 2011;1814(9):1154-61.
2011: Matías A Musumeci; Horacio Botti; Alejandro Buschiazzo; Eduardo A Ceccarelli
Swapping FAD binding motifs between plastidic and bacterial ferredoxin-NADP(H) reductases.
Biochemistry 2011;50(12):2111-22.
2010: Javier M González; Alejandro Buschiazzo; Alejandro J Vila
Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases .
Biochemistry 2010;49(36):7930-8.
2010: Martin Graña; Marco Bellinzoni; Jacques Bellalou; Ahmed Haouz; Isabelle Miras; Alejandro Buschiazzo; Nathalie Winter; Pedro Alzari
Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.
Proteins 2010;78(3):769-72.
2009: Martin Graña; Marco Bellinzoni; Isabelle Miras; Cedric Fiez-Vandal; Ahmed Haouz; William Shepard; Alejandro Buschiazzo; Pedro Alzari
Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 10):972-7.
2009: Daniela Albanesi; Mariana Martín; Felipe Trajtenberg; María C Mansilla; Ahmed Haouz; Pedro Alzari; Diego de Mendoza; Alejandro Buschiazzo
Structural plasticity and catalysis regulation of a thermosensor histidine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16185-90.
2009: João Neres; Mark L Brewer; Laura Ratier; Horacio Botti; Alejandro Buschiazzo; Philip N Edwards; Paul N Mortenson; Michael H Charlton; Pedro Alzari; Alberto C Frasch; Richard A Bryce; Kenneth T Douglas
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.
Bioorganic & medicinal chemistry letters 2009;19(3):589-96.
2008: Alejandro Buschiazzo; Pedro Alzari
Structural insights into sialic acid enzymology.
Current opinion in chemical biology 2008;12(5):565-72.
2008: Iben Damager; Sabrina Buchini; Maria F Amaya; Alejandro Buschiazzo; Pedro Alzari; Alberto C C Frasch; Andrew Watts; Stephen G Withers
Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis.
Biochemistry 2008;47(11):3507-12.
2008: Sabrina Buchini; Alejandro Buschiazzo; Stephen G Withers
A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors.
Angewandte Chemie (International ed. in English) 2008;47(14):2700-3.
2007: Martin Graña; Ahmed Haouz; Alejandro Buschiazzo; Isabelle Miras; Annemarie Wehenkel; Vincent Bondet; William Shepard; Francis Schaeffer; Stewart T Cole; Pedro Alzari
The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria.
Protein science : a publication of the Protein Society 2007;16(9):1896-904.
2007: Marcelo E Guerin; Jana Kordulakova; Francis Schaeffer; Zuzana Svetlikova; Alejandro Buschiazzo; David Giganti; Brigitte Gicquel; Katarina Mikusova; Mary Jackson; Pedro Alzari
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.
The Journal of biological chemistry 2007;282(28):20705-14.
2007: João Neres; Pascal Bonnet; Philip N Edwards; Pravin L Kotian; Alejandro Buschiazzo; Pedro Alzari; Richard A Bryce; Kenneth T Douglas
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.
Bioorganic & medicinal chemistry 2007;15(5):2106-19.
2007: William Shepard; Ahmed Haouz; Martin Graña; Alejandro Buschiazzo; Jean-Michel Betton; Stewart T Cole; Pedro Alzari
The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.
Journal of bacteriology 2007;189(5):1899-904.
2006: João Neres; Alejandro Buschiazzo; Pedro Alzari; Lindsey Walsh; Kenneth T Douglas
Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi.
Analytical biochemistry 2006;357(2):302-4.
2006: Gustavo Schujman; Marcelo E Guerin; Alejandro Buschiazzo; Francis Schaeffer; Leticia I Llarrull; Georgina Reh; Alejandro J Vila; Pedro Alzari; Diego de Mendoza
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.
The EMBO journal 2006;25(17):4074-83.
2006: Andrew G Watts; Pablo Oppezzo; Stephen G Withers; Pedro Alzari; Alejandro Buschiazzo
Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase.
The Journal of biological chemistry 2006;281(7):4149-55.
2006: Alejandro Buschiazzo; Maira Goytia; Francis Schaeffer; Wim Degrave; William Shepard; Christophe Grégoire; Nathalie Chamond; Alain Cosson; Armand Berneman; Nicolas Coatnoan; Pedro Alzari; Paola Minoprio
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1705-10.
2005: Marcelo E Guerin; Alejandro Buschiazzo; Jana Korduláková; Mary Jackson; Pedro Alzari
Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 5):518-20.
2004: Alejandro Buschiazzo; Juan E Ugalde; Marcelo E Guerin; William Shepard; Rodolfo A Ugalde; Pedro Alzari
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation.
The EMBO journal 2004;23(16):3196-205.
2004: María Fernanda Amaya; Andrew G Watts; Iben Damager; Annemarie Wehenkel; Tong Nguyen; Alejandro Buschiazzo; Gaston Paris; Alberto C C Frasch; Stephen G Withers; Pedro Alzari
Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase.
Structure (London, England : 1993) 2004;12(5):775-84.
2003: Andrew G Watts; Iben Damager; Maria L Amaya; Alejandro Buschiazzo; Pedro Alzari; Alberto C C Frasch; Stephen G Withers
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile.
Journal of the American Chemical Society 2003;125(25):7532-3.
2003: Marcelo E Guerin; Alejandro Buschiazzo; Juan E Ugalde; Rodolfo A Ugalde; Pedro Alzari
Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 3):526-8.
2003: María Fernanda Amaya; Alejandro Buschiazzo; Tong Nguyen; Pedro Alzari
The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase.
Journal of molecular biology 2003;325(4):773-84.
2002: Alejandro Buschiazzo; María Fernanda Amaya; Maria Laura Cremona; Alberto C C Frasch; Pedro Alzari
The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis.
Molecular cell 2002;10(4):757-68.
2002: Georgina Montagna; Maria Laura Cremona; Gaston Paris; María Fernanda Amaya; Alejandro Buschiazzo; Pedro Alzari; Alberto C C Frasch
The trans-sialidase from the african trypanosome Trypanosoma brucei.
European journal of biochemistry / FEBS 2002;269(12):2941-50.
2001: Gaston Paris; Maria Laura Cremona; María Fernanda Amaya; Alejandro Buschiazzo; S Giambiagi; Alberto C C Frasch; Pedro Alzari
Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity.
Glycobiology 2001;11(4):305-11.
2000: Alejandro Buschiazzo; GA Tavares; Oscar Campetella; S Spinelli; Maria Laura Cremona; G París; María Fernanda Amaya; Alberto C C Frasch; Pedro Alzari
Structural basis of sialyltransferase activity in trypanosomal sialidases.
The EMBO journal 2000;19(1):16-24.
1997: Alejandro Buschiazzo; Oscar Campetella; Alberto C C Frasch
Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase.
Glycobiology 1997;7(8):1167-73.