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Ashley Bush

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Scott Ayton; Ashley I Bush; Robert A Cherny; Paul A Adlard; Jessica L George; David I Finkelstein
The effect of dopamine on MPTP-induced rotarod disability.
Mark A Greenough; James Camakaris; Ashley I Bush
Metal dyshomeostasis and oxidative stress in Alzheimer's disease.
James A Duce; D I Finkelstein; T J Kilpatrick; L Q Lam; L Leone; A A Miller; Jack T Rogers; A Tsatsanis; S Ayton; Kevin J Barnham; H Butzkueven; J E Corbin; Ashley I Bush
Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.

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All Publications

2013: Scott Ayton; Ashley I Bush; Robert A Cherny; Paul A Adlard; Jessica L George; David I Finkelstein
The effect of dopamine on MPTP-induced rotarod disability.
Neuroscience letters 2013;543():105-9.
2013: Mark A Greenough; James Camakaris; Ashley I Bush
Metal dyshomeostasis and oxidative stress in Alzheimer's disease.
Neurochemistry international 2013;62(5):540-55.
2013: James A Duce; D I Finkelstein; T J Kilpatrick; L Q Lam; L Leone; A A Miller; Jack T Rogers; A Tsatsanis; S Ayton; Kevin J Barnham; H Butzkueven; J E Corbin; Ashley I Bush
Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.
Molecular psychiatry 2013;18(2):245-54.
2013: Adam Southon; Richard Burke; Ashley I Bush; George Ganio; Mark A Greenough; James Camakaris
Presenilin promotes dietary copper uptake.
PloS one 2013;8(5):e62811.
2013: Kathryn A Ellis; Karra Harrington; Yen Ying Lim; Ralph N Martins; Paul Maruff; Colin L Masters; Christopher C Rowe; Greg Savage; Cassandra E I Szoeke; Victor L Villemagne; David Ames; Ashley I Bush; David Darby
Decline in cognitive function over 18 months in healthy older adults with high amyloid-β.
Journal of Alzheimer's disease : JAD 2013;34(4):861-71.
2013: Alan Rembach; Blaine R Roberts; Christopher C Rowe; Rebecca L Rumble; Brett O Trounson; Victor L Villemagne; Irene Volitakis; Andrew D Watt; William Wilson; James D Doecke; Kathryn A Ellis; Noel G Faux; Christopher J Fowler; Ralph N Martins; Colin L Masters; Kelly K Pertile; David Ames; Ashley I Bush
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;34(1):171-82.
2013: Yen Ying Lim; Ralph N Martins; David Ames; Ashley I Bush; David Darby; Kathryn A Ellis; Joanne Gale; Karra Harrington; Colin L Masters; Robert H Pietrzak; Christopher C Rowe; Greg Savage; Cassandra E I Szoeke; Victor L Villemagne; Paul Maruff
Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer's disease?
Journal of Alzheimer's disease : JAD 2013;33(4):1167-76.
2013: Yen Ying Lim; Ralph N Martins; David Ames; Tim Ashwood; Ashley I Bush; David Darby; Kathryn A Ellis; Karra Harrington; Judith Jaeger; Colin L Masters; Robert H Pietrzak; Christopher C Rowe; Cassandra E I Szoeke; Victor L Villemagne; Paul Maruff
Rapid decline in episodic memory in healthy older adults with high amyloid-β.
Journal of Alzheimer's disease : JAD 2013;33(3):675-9.
2013: Ashley I Bush
The metal theory of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S277-81.
2012: Yasmina Manso; Paul A Adlard; Ashley I Bush; Javier Carrasco; Gemma Comes; Juan Hidalgo
Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease.
Cellular and molecular life sciences : CMLS 2012;69(21):3665-81.
2012: Yasmina Manso; Gabriele Meloni; Milan Vašák; Paul A Adlard; Ashley I Bush; Javier Carrasco; Gemma Comes; Juan Hidalgo
Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease.
Cellular and molecular life sciences : CMLS 2012;69(21):3683-700.
2012: Olivia M Dean; Susan Jeavons; Kristy Kohlmann; Ian Schapkaitz; Murray Anderson-Hunt; Ashley I Bush; David L Copolov; Michael Berk
Effects of N-acetyl cysteine on cognitive function in bipolar disorder.
Psychiatry and clinical neurosciences 2012;66(6):514-7.
2012: James D Doecke; Kathryn A Ellis; Noel G Faux; Christopher Fowler; Veer B Gupta; Richard Head; Chiou-Peng Lam; Simon M Laws; S Lance Macaulay; Ralph N Martins; Colin L Masters; Alinda Mondal; Kelly Pertile; Alan Rembach; Mark Rodrigues; Christopher C Rowe; Rebecca Rumble; Cassandra Szoeke; Kevin Taddei; Tania Taddei; Brett Trounson; William Wilson; David Ames; Justin Bedo; Belinda Brown; Samantha C Burnham; Ashley I Bush; Karl De Ruyck
Blood-based protein biomarkers for diagnosis of Alzheimer disease.
Archives of neurology 2012;69(10):1318-25.
2012: Olivia M Dean; Ashley I Bush; Michael Berk
Translating the Rosetta Stone of N-acetylcysteine.
Biological psychiatry 2012;71(11):935-6.
2012: Ben J Gu; Steven Petrou; Valentina A Valova; Ashley I Bush; James A Duce; Bruce Wong; James S Wiley
P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid.
The Journal of biological chemistry 2012;287(21):17318-30.
2012: Hongyun Li; Ashley I Bush; Geneviève Evin; Andrew F Hill; Ya Hui Hung; Brett Garner
Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues.
Clinical science (London, England : 1979) 2012;122(9):409-19.
2012: Lin W Hung; Su Ling Leong; SinChun Lim; Xiang Liu; Colin L Masters; Graeme O'Keefe; Chi L L Pham; Andrew K Powell; Blaine R Roberts; David M Shackleford; Nicki A Sherratt; Victor L Villemagne; Anthony R White; Simon Wilkins; Ashley I Bush; Roberto Cappai; Lesley Cheng; Robert A Cherny; Francis C K Chiu; Peter J Crouch; Janetta G Culvenor; Paul S Donnelly; David I Finkelstein; Jessica George; Andrew F Hill; Scott Ayton; Kevin J Barnham
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.
The Journal of experimental medicine 2012;209(4):837-54.
2012: Peng Lei; Catriona A McLean; Blaine R Roberts; Loredana Spoerri; Irene Volitakis; Bruce X W Wong; David K Wright; Roberto Cappai; Robert A Cherny; Giuseppe D Ciccotosto; James A Duce; Gary F Egan; David I Finkelstein; Linh Q Lam; Paul A Adlard; Scott Ayton; Ashley I Bush
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
Nature medicine 2012;18(2):291-5.
2012: Gawain McColl; Tara L Pukala; Blaine R Roberts; Christine M Roberts; Timothy M Ryan; Kevin J Barnham; Ashley I Bush; Vijaya Kenche; Christopher D Link; Colin L Masters; Robert A Cherny
Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
Molecular neurodegeneration 2012;7():57.
2012: Michael Berk; Ashley I Bush; Heidi Cobb; Sue M Cotton; Olivia M Dean; Seetal Dodd; Brisa Fernandes; Clarissa S Gama; Karen Hewitt; Susan Jeavons; Flavio Kapczinski; Kristy Kohlmann; Kirsteen Moss; Ian Schapkaitz; Christine Allwang; Gin S Malhi
Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial.
BMC medicine 2012;10():91.
2012: Adam P Gunn; Blaine R Roberts; Ashley I Bush
Rapid generation of dityrosine cross-linked Aβ oligomers via Cu-redox cycling.
Methods in molecular biology (Clifton, N.J.) 2012;849():3-10.
2012: Gawain McColl; Gareth F Moorhead; David Paterson; Christopher G Ryan; Martin D de Jonge; Daryl L Howard; Simon A James; Robin Kirkham; Sheridan Mayo; Ashley I Bush
Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
PloS one 2012;7(2):e32685.
2011: Michael Berk; Ashley I Bush; Heidi Cobb; Sue M Cotton; Olivia Dean; Seetal Dodd; Brisa Fernandes; Clarissa S Gama; Karen Hewitt; Susan Jeavons; Flavio Kapczinski; Kristy Kohlmann; Christine Allwang; Ian Schapkaitz; Gin S Malhi
The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial.
Journal of affective disorders 2011;135(1-3):389-94.
2011: Peter J Crouch; Paul S Donnelly; Mark A Greenough; Lin W Hung; Colin L Masters; Alexandra I Mot; Sarah J Parker; Maria S Savva; Irene Volitakis; Paul A Adlard; Kevin J Barnham; Ashley I Bush; Robert A Cherny; Anthony R White
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
Journal of neurochemistry 2011;119(1):220-30.
2011: Olivia M Dean; Christine Mavros; Maarten van den Buuse; Michael Berk; David L Copolov; Ashley I Bush
N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder.
Neuroscience letters 2011;499(3):149-53.
2011: Michael Berk; Murray Anderson-Hunt; Philippe Conus; David L Copolov; Olivia Dean; Barbara Hanna; Sue Jeavons; Fiona Katz; Kristy Kohlmann; Gin S Malhi; Ahmed Munib; Felicity Ng; Renée Otmar; Ian Schapkaitz; Ashley I Bush
Qualitative methods in early-phase drug trials: broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia.
The Journal of clinical psychiatry 2011;72(7):909-13.
2011: Jonathan H Fox; Teal Connor; Megan Stiles; Jibrin Kama; Zhen Lu; Kathryn Dorsey; Gregory Liebermann; Ellen Sapp; Robert A Cherny; Mary Banks; Irene Volitakis; Marian DiFiglia; Oksana Berezovska; Ashley I Bush; Gregory Lieberman; Steven M Hersch
Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.
The Journal of biological chemistry 2011;286(20):18320-30.
2011: V B Gupta; Simon Laws; Victor L Villemagne; D Ames; Ashley I Bush; K A Ellis; J K Lui; Colin L Masters; Christopher C Rowe; C Szoeke; Kevin Taddei; Ralph N Martins
Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.
Neurology 2011;76(12):1091-8.
2011: Mark A Greenough; Irene Volitakis; Qiao-Xin Li; Katrina Laughton; Genevieve Evin; Michael Ho; Andrew H Dalziel; James Camakaris; Ashley I Bush
Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
The Journal of biological chemistry 2011;286(11):9776-86.
2011: Karla M Acevedo; Ya Hui Hung; Andrew H Dalziel; Qiao-Xin Li; Katrina Laughton; Krutika Wikhe; Alan Rembach; Blaine Roberts; Colin L Masters; Ashley I Bush; James Camakaris
Copper promotes the trafficking of the amyloid precursor protein.
The Journal of biological chemistry 2011;286(10):8252-62.
2011: P A Adlard; Ashley I Bush
The plasma membrane redox system in Alzheimer's disease.
Experimental neurology 2011;228(1):9-14.
2011: Daniela Kaden; Thomas A Bayer; Ashley I Bush; Ruth Danzeisen; Gerd Multhaup
Disturbed copper bioavailability in Alzheimer's disease.
International journal of Alzheimer's disease 2011;2011():345614.
2011: Ashley I Bush
A Copper Binding Site within the Pathological Conformer Epitope of Mutant SOD1.
Frontiers in neuroscience 2011;5():97.
2011: Yasmina Manso; Ashley I Bush; Gemma Comes; Juan Hidalgo; Paul A Adlard
Copper modulation as a therapy for Alzheimer's disease?
International journal of Alzheimer's disease 2011;2011():370345.
2011: Peng Lei; Scott Ayton; Ashley I Bush; Paul A Adlard
GSK-3 in Neurodegenerative Diseases.
International journal of Alzheimer's disease 2011;2011():189246.
2011: Paul A Adlard; Laura Bica; Anthony R White; Milawaty Nurjono; Gulay Filiz; Peter J Crouch; Paul S Donnelly; Roberto Cappai; David I Finkelstein; Ashley I Bush
Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.
PloS one 2011;6(3):e17669.
2011: Gobhathai Sittironnarit; David Ames; Ashley I Bush; Noel Faux; Leon Flicker; Jonathan Foster; Sarah Hilmer; Nicola T Lautenschlager; Paul Maruff; Colin L Masters; Ralph N Martins; Christopher C Rowe; Cassandra Szoeke; Kathryn A Ellis
Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study.
Dementia and geriatric cognitive disorders 2011;31(3):173-8.
2010: Kwok Ho Christopher Choy; Olivia Dean; Michael Berk; Ashley I Bush; Maarten van den Buuse
Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats.
European journal of pharmacology 2010;649(1-3):224-8.
2010: Olivia Dean; Ashley I Bush; Michael Berk; David L Copolov; Maarten van den Buuse
Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice.
Pharmacology, biochemistry, and behavior 2010;97(2):293-300.
2010: Joo-Yong Lee; Eunsil Cho; Tae-Youn Kim; Dong-Kyu Kim; Richard D Palmiter; Irene Volitakis; Jong S Kim; Ashley I Bush; Jae-Young Koh
Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2010;23(6):1085-95.
2010: Dominic J Hare; Jessica L George; Rudolf Grimm; Simon Wilkins; Paul A Adlard; Robert A Cherny; Ashley I Bush; David I Finkelstein; Philip Doble
Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain.
Metallomics : integrated biometal science 2010;2(11):745-53.
2010: Peng Lei; Scott Ayton; David I Finkelstein; Paul A Adlard; Colin L Masters; Ashley I Bush
Tau protein: relevance to Parkinson's disease.
The international journal of biochemistry & cell biology 2010;42(11):1775-8.
2010: James A Duce; Andrew Tsatsanis; Michael A Cater; Simon A James; Elysia Robb; Krutika Wikhe; Su Ling Leong; Keyla Perez; Timothy Johanssen; Mark A Greenough; Hyun-Hee Cho; Denise Galatis; Robert D. Moir; Colin L Masters; Catriona McLean; Rudolph E Tanzi; Roberto Cappai; Kevin J Barnham; Giuseppe D Ciccotosto; Jack T Rogers; Ashley I Bush
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Cell 2010;142(6):857-67.
2010: Gawain McColl; Aric N Rogers; Silvestre Alavez; Alan E Hubbard; Simon Melov; Christopher D Link; Ashley I Bush; pankaj kapahi; Gordon J Lithgow
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.
Cell metabolism 2010;12(3):260-72.
2010: Zhiqiang Zheng; Carine White; Jaekwon Lee; Troy S Peterson; Ashley I Bush; Grace Y Sun; Gary A Weisman; Michael J Petris
Altered microglial copper homeostasis in a mouse model of Alzheimer's disease.
Journal of neurochemistry 2010;114(6):1630-8.
2010: James A Duce; Ashley I Bush
Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics.
Progress in neurobiology 2010;92(1):1-18.
2010: Victoria M Perreau; Sandra Orchard; Paul A Adlard; Shayne A Bellingham; Roberto Cappai; Giuseppe D Ciccotosto; Tiffany F Cowie; Peter J Crouch; James A Duce; Geneviève Evin; Noel G Faux; Andrew Hill; Ya Hui Hung; Simon A James; Qiao-Xin Li; Su San Mok; Deborah J Tew; Anthony R White; Ashley I Bush; Henning Hermjakob; Colin L Masters
A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease.
Proteomics 2010;10(12):2377-95.
2010: Fredrik Haeffner; Kevin J Barnham; Ashley I Bush; Tore Brinck
Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study.
Journal of molecular modeling 2010;16(6):1103-8.
2010: Wah Chin Boon; Maarten van den Buuse; Nico Wegener; Sally Martin; Hui Kheng Chua; Ashley I Bush; Colin L Masters; Paul A Adlard; Qiao-Xin Li
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density.
Behavioural brain research 2010;209(1):27-35.
2010: Hitoshi Kishigami; Seiichi Nagano; Ashley I Bush; Saburo Sakoda
Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding.
Free radical biology & medicine 2010;48(7):945-52.
2010: Paul A Adlard; Jacqui M Parncutt; David Finkelstein; Ashley I Bush
Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(5):1631-6.
2010: Larry Baum; Iris H S Chan; Stanley Kwok-Kuen Cheung; William Goggins; Vincent Mok; Linda Lam; Vivian Leung; Elsie Hui; Chelsia Ng; Jean Woo; Helen Fung Kum Chiu; Benny Chung-Ying Zee; William Cheng; Ming-Houng Chan; Samuel Szeto; Victor W C Lui; Joshua Tsoh; Ashley I Bush; Christopher Wai-Kei Lam; Timothy Kwok
Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2010;23(1):173-9.
2010: Ashley I Bush
Kalzium ist nicht alles.
Neuron 2010;65(2):143-4.
2010: Melanie Norgate; Adam Southon; Mark Greenough; Michael Cater; Ashley Farlow; Philip Batterham; Ashley I Bush; V Nathan Subramaniam; Richard Burke; James Camakaris
Syntaxin 5 is required for copper homeostasis in Drosophila and mammals.
PloS one 2010;5(12):e14303.
2010: James K Lui; Simon Laws; Qiao-Xin Li; Victor L Villemagne; David Ames; Belinda Brown; Ashley I Bush; Karl De Ruyck; Jasmin Dromey; Kathryn A Ellis; Noel G Faux; Jonathan Foster; Christopher Fowler; Veer Gupta; Peter Hudson; Katrina Laughton; Colin L Masters; Kelly Pertile; Alan Rembach; Mira Rimajova; Mark Rodrigues; Christopher C Rowe; Rebecca Rumble; Cassandra Szoeke; Kevin Taddei; Tania Taddei; Brett Trounson; Vanessa Ward; Ralph N Martins
Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging.
Journal of Alzheimer's disease : JAD 2010;20(4):1233-42.
2010: Noel G Faux; Craig W Ritchie; Adam Gunn; Alan Rembach; Andrew Tsatsanis; Justin Bedo; John Edward Harrison; Lars Lannfelt; Kaj Blennow; Henrik Zetterberg; Martin Ingelsson; Colin L Masters; Rudolph E Tanzi; Jeffrey L Cummings; Caroline M Herd; Ashley I Bush
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses.
Journal of Alzheimer's disease : JAD 2010;20(2):509-16.
2010: Ya Hui Hung; Ashley I Bush; Robert Alan Cherny
Copper in the brain and Alzheimer's disease.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(1):61-76.
2009: Stefano L Sensi; Pierre Paoletti; Ashley I Bush; Israel Sekler
Zinc in the physiology and pathology of the CNS.
Nature reviews. Neuroscience 2009;10(11):780-91.
2009: Gawain McColl; Blaine R Roberts; Adam P Gunn; Keyla A Perez; Deborah J Tew; Colin L Masters; Kevin J Barnham; Robert A Cherny; Ashley I Bush
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.
The Journal of biological chemistry 2009;284(34):22697-702.
2009: Ya Hui Hung; Elysia L Robb; Irene Volitakis; Michael Ho; Genevieve Evin; Qiao-Xin Li; Janetta G Culvenor; Colin L Masters; Robert A Cherny; Ashley I Bush
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.
The Journal of biological chemistry 2009;284(33):21899-907.
2009: Kathryn A Ellis; Ashley I Bush; David Darby; Daniela De Fazio; Jonathan Foster; Peter Hudson; Nicola T Lautenschlager; Nat Lenzo; Ralph N Martins; Paul Maruff; Colin L Masters; Andrew Milner; Kerryn Pike; Christopher C Rowe; Greg Savage; Cassandra Szoeke; Kevin Taddei; Victor L Villemagne; Michael Woodward; David Ames
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease.
International psychogeriatrics / IPA 2009;21(4):672-87.
2009: Christa J Maynard; Roberto Cappai; Irene Volitakis; Katrina M Laughton; Colin L Masters; Ashley I Bush; Qiao-Xin Li
Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice.
Cellular and molecular neurobiology 2009;29(5):757-67.
2009: Dorothea Strozyk; Lenore J Launer; Paul A Adlard; Robert A Cherny; Andrew Tsatsanis; Irene Volitakis; Kaj Blennow; Helen Petrovitch; Lon R White; Ashley I Bush
Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.
Neurobiology of aging 2009;30(7):1069-77.
2009: Carine White; Taiho Kambe; Yan G Fulcher; Sherri W Sachdev; Ashley I Bush; Kevin Fritsche; Jaekwon Lee; Thomas P Quinn; Michael J Petris
Copper transport into the secretory pathway is regulated by oxygen in macrophages.
Journal of cell science 2009;122(Pt 9):1315-21.
2009: Paul A Adlard; Simon A James; Ashley I Bush; Colin L Masters
beta-Amyloid as a molecular therapeutic target in Alzheimer's disease.
Drugs of today (Barcelona, Spain : 1998) 2009;45(4):293-304.
2009: Giuseppe Grasso; Ashley I Bush; Roberta D'Agata; Enrico Rizzarelli; Giuseppe Spoto
Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme.
European biophysics journal : EBJ 2009;38(4):407-14.
2009: Olivia Dean; Ashley I Bush; Michael Berk; David L Copolov; Maarten van den Buuse
Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice.
Behavioural brain research 2009;198(1):258-62.
2009: J L George; S Mok; David Moses; S Wilkins; Ashley I Bush; R A Cherny; David Finkelstein
Targeting the progression of Parkinson's disease.
Current neuropharmacology 2009;7(1):9-36.
2009: Peter J Crouch; Lin Wai Hung; Paul A Adlard; Mikhalina Cortes; Varsha Lal; Gulay Filiz; Keyla Perez; Milawaty Nurjono; Aphrodite Caragounis; Tai Du; Katrina Laughton; Irene Volitakis; Ashley I Bush; Qiao-Xin Li; Colin L Masters; Roberto Cappai; Robert A Cherny; Paul S Donnelly; Anthony R White; Kevin J Barnham
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):381-6.
2009: O M Dean; M van den Buuse; Ashley I Bush; D L Copolov; F Ng; S Dodd; Michael Berk
A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice.
Current medicinal chemistry 2009;16(23):2965-76.
2009: Kamille Smidt; Niels Jessen; Andreas Brønden Petersen; Agnete Larsen; Nils Magnusson; Johanne Bruun Jeppesen; Meredin Stoltenberg; Janetta G Culvenor; Andrew Tsatsanis; Birgitte Brock; Ole Schmitz; Lise Wogensen; Ashley I Bush; Jørgen Rungby
SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.
PloS one 2009;4(5):e5684.
2009: Alicia N Minniti; Carlos Opazo; Daniela L Rebolledo; Irene Volitakis; Rebeca Aldunate; Ashley I Bush; Robert A Cherny; Ricardo Fadic; Paula M Grez; Colin Masters; Nibaldo C Inestrosa
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.
Molecular neurodegeneration 2009;4():2.
2009: Yif'at Biran; Colin L Masters; Kevin J Barnham; Ashley I Bush; Paul A Adlard
Pharmacotherapeutic targets in Alzheimer's disease.
Journal of cellular and molecular medicine 2009;13(1):61-86.
2008: Jack T Rogers; Ashley I Bush; Hyan-Hee Cho; Deborah H Smith; Andrew M Thomson; Avi Friedlich; Debomoy K Lahiri; Peter J Leedman; Xudong Huang; Catherine M Cahill
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.
Biochemical Society transactions 2008;36(Pt 6):1282-7.
2008: Wei-Hui Wu; Peng Lei; Qian Liu; Jia Hu; Adam P Gunn; Mei-sha Chen; Yan-fang Rui; Xiao-Yang Su; Zuo-Ping Xie; Yu-Fen Zhao; Ashley I Bush; Yan-Mei Li
Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents.
The Journal of biological chemistry 2008;283(46):31657-64.
2008: Ashley I Bush
Drug development based on the metals hypothesis of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2008;15(2):223-40.
2008: Michael Berk; David Copolov; Olivia Dean; Kristy Lu; Sue Jeavons; Ian Schapkaitz; Murray Anderson-Hunt; Ashley I Bush
N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial.
Biological psychiatry 2008;64(6):468-75.
2008: Lars Lannfelt; Kaj Blennow; Henrik Zetterberg; Stellan Batsman; David Ames; John Edward Harrison; Colin L Masters; Steve Targum; Ashley I Bush; Ross Murdoch; Janet Wilson; Craig W Ritchie
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.
Lancet neurology 2008;7(9):779-86.
2008: Michael Berk; David Copolov; Olivia Dean; Kristy Lu; Sue Jeavons; Ian Schapkaitz; Murray Anderson-Hunt; Fiona Judd; Fiona Katz; Paul Katz; Sean Ording-Jespersen; John Little; Philippe Conus; Michel Cuenod; Kim Q Do; Ashley I Bush
N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial.
Biological psychiatry 2008;64(5):361-8.
2008: Felicity Ng; Michael Berk; Olivia Dean; Ashley I Bush
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2008;11(6):851-76.
2008: Suzie Lavoie; Micah M Murray; Patricia Deppen; Maria G Knyazeva; Michael Berk; Olivier Boulat; Pierre Bovet; Ashley I Bush; Philippe Conus; David Copolov; Eleonora Fornari; Reto Meuli; Alessandra Solida; Pascal Vianin; Michel Cuénod; Thierry Buclin; Kim Q Do
Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(9):2187-99.
2008: Paul A Adlard; Robert A Cherny; David Finkelstein; Elisabeth Gautier; Elysia Robb; Mikhalina Cortes; Irene Volitakis; Xiang Liu; Jeffrey P Smith; Keyla Perez; Katrina Laughton; Qiao-Xin Li; Susan A Charman; Joseph A Nicolazzo; Simon Wilkins; Karolina Deleva; Toni Lynch; Gaik Kok; Craig W Ritchie; Rudolph E Tanzi; Roberto Cappai; Colin L Masters; Kevin J Barnham; Ashley I Bush
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
2008: Ashley I Bush; Rudolph E Tanzi
Therapeutics for Alzheimer's disease based on the metal hypothesis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):421-32.
2008: Michael Berk; Felicity Ng; Olivia Dean; Seetal Dodd; Ashley I Bush
Glutathione: a novel treatment target in psychiatry.
Trends in pharmacological sciences 2008;29(7):346-51.
2008: Michael A Cater; Kelly T McInnes; Qiao-Xin Li; Irene Volitakis; Sharon La Fontaine; Julian F B Mercer; Ashley I Bush
Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
The Biochemical journal 2008;412(1):141-52.
2008: Kevin J Barnham; Vijaya Kenche; Giuseppe D Ciccotosto; David P Smith; Deborah J Tew; Xiang Liu; Keyla Perez; Greg A Cranston; Timothy J Johanssen; Irene Volitakis; Ashley I Bush; Colin L Masters; Anthony R White; Jeffrey P Smith; Robert A Cherny; Roberto Cappai
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6813-8.
2008: Tai Du; Sharon L La Fontaine; Michael Abdo; Shayne A Bellingham; Mark Greenough; Irene Volitakis; Robert A Cherny; Ashley I Bush; Peter J Hudson; James Camakaris; Julian F B Mercer; Peter J Crouch; Colin L Masters; Victoria M Perreau; Anthony R White
Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays.
Proteomics 2008;8(9):1819-31.
2008: Kevin J Barnham; Ashley I Bush
Metals in Alzheimer's and Parkinson's diseases.
Current opinion in chemical biology 2008;12(2):222-8.
2008: Robert A Colvin; Ashley I Bush; Irene Volitakis; Charles P Fontaine; Dustin Thomas; Kazuya Kikuchi; William R Holmes
Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.
American journal of physiology. Cell physiology 2008;294(3):C726-42.
2008: Ashley I Bush; Cyril C Curtain
Twenty years of metallo-neurobiology: where to now?
European biophysics journal : EBJ 2008;37(3):241-5.
2008: Seiichi Nagano; Ashley I Bush
Sensitive, selective, and irreversible inhibition of cyclooxygenase-2 activity by copper.
ChemMedChem 2008;3(2):223-5.
2008: Peter J Crouch; Susan-Marie E Harding; Anthony R White; James Camakaris; Ashley I Bush; Colin L Masters
Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease.
The international journal of biochemistry & cell biology 2008;40(2):181-98.
2007: Meredin Stoltenberg; Ashley I Bush; G Bach; Kamille Smidt; Agnete Larsen; Jørgen Rungby; S Lund; Peter Doering; Gorm Danscher
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency.
Neuroscience 2007;150(2):357-69.
2007: Peter J Crouch; K Cimdins; James A Duce; Ashley I Bush; Ian A Trounce
Mitochondria in aging and Alzheimer's disease.
Rejuvenation research 2007;10(3):349-57.
2007: Peter J Crouch; Anthony R White; Ashley I Bush
The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
The FEBS journal 2007;274(15):3775-83.
2007: Shohei Watanabe; Seiichi Nagano; James Duce; Mahmoud Kiaei; Qiao-Xin Li; Stephanie M Tucker; Ashutosh Tiwari; Robert H Brown; M Flint Beal; Lawrence J Hayward; Valeria Cizewski Culotta; Satoshi Yoshihara; Saburo Sakoda; Ashley I Bush
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
Free radical biology & medicine 2007;42(10):1534-42.
2007: Simon Melov; Paul A Adlard; Karl J Morten; Felicity Johnson; Tamara R Golden; Douglas Hinerfeld; Birgit Schilling; Christine Mavros; Colin L Masters; Irene Volitakis; Qiao-Xin Li; Katrina Laughton; Alan Hubbard; Robert A Cherny; Bradford Gibson; Ashley I Bush
Mitochondrial oxidative stress causes hyperphosphorylation of tau.
PloS one 2007;2(6):e536.
2007: Jonathan H Fox; Jibrin A Kama; Gregory Lieberman; Raman Chopra; Kate Dorsey; Vanita Chopra; Irene Volitakis; Robert A Cherny; Ashley I Bush; Steven M Hersch
Mechanisms of copper ion mediated Huntington's disease progression.
PloS one 2007;2(3):e334.
2006: Paul A Adlard; Ashley I Bush
Metals and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;10(2-3):145-63.
2006: Peter J Crouch; Kevin J Barnham; Ashley I Bush; Anthony R White
Therapeutic treatments for Alzheimer's disease based on metal bioavailability.
Drug news & perspectives 2006;19(8):469-74.
2006: D Religa; Dorothea Strozyk; Robert A Cherny; Irene Volitakis; Vahram Haroutunian; Bengt Winblad; J Naslund; Ashley I Bush
Elevated cortical zinc in Alzheimer disease.
Neurology 2006;67(1):69-75.
2006: Stephanie Tucker; Michelle Ahl; Hyun-Hee Cho; Sanghamitra Bandyopadhyay; Gregory D Cuny; Ashley I Bush; Lee E Goldstein; David Westaway; Xudong Huang; Jack T Rogers
RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.
Current Alzheimer research 2006;3(3):221-7.
2006: Anthony R White; Tai Du; Katrina M Laughton; Irene Volitakis; Robyn A Sharples; Michel E Xilinas; David E Hoke; R. M. Damian Holsinger; Geneviève Evin; Robert A Cherny; Andrew Hill; Kevin J Barnham; Qiao-Xin Li; Ashley I Bush; Colin L Masters
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
The Journal of biological chemistry 2006;281(26):17670-80.
2006: David P Smith; Danielle G Smith; Cyril C Curtain; John F Boas; John R Pilbrow; Giuseppe D Ciccotosto; Tong-Lay Crystal Lau; Deborah J Tew; Keyla Perez; John D Wade; Ashley I Bush; Simon C Drew; Frances Separovic; Colin L Masters; Roberto Cappai; Kevin J Barnham
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
The Journal of biological chemistry 2006;281(22):15145-54.
2006: Anthony R White; Kevin J Barnham; Ashley I Bush
Metal homeostasis in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(5):711-22.
2006: Christa Maynard; Roberto Cappai; Irene Volitakis; Robert A Cherny; Colin L Masters; Qiao-Xin Li; Ashley I Bush
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.
Journal of inorganic biochemistry 2006;100(5-6):952-62.
2006: Carlos Opazo; Sandra Luza; Victor L Villemagne; Irene Volitakis; Christopher C Rowe; Kevin J Barnham; Dorothea Strozyk; Colin L Masters; Robert A Cherny; Ashley I Bush
Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
Aging cell 2006;5(1):69-79.
2005: Ambreena Siddiq; Issam Ayoub; Juan C Chavez; Leila Aminova; Sapan Shah; Joseph C LaManna; Stephanie M Patton; James Connor; Robert A Cherny; Irene Volitakis; Ashley I Bush; Ingrid Langsetmo; Todd Seeley; Volkmar Gunzler; Rajiv R Ratan
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
The Journal of biological chemistry 2005;280(50):41732-43.
2005: Fredrik Haeffner; Danielle G Smith; Kevin J Barnham; Ashley I Bush
Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry.
Journal of inorganic biochemistry 2005;99(12):2403-22.
2005: Luigi Puglielli; Avi Friedlich; Kenneth D R Setchell; Seiichi Nagano; Carlos Opazo; Robert A Cherny; Kevin J Barnham; John D Wade; Simon Melov; Dora M. Kovacs; Ashley I Bush
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
The Journal of clinical investigation 2005;115(9):2556-63.
2005: Christa Maynard; Ashley I Bush; Colin L Masters; Roberto Cappai; Qiao-Xin Li
Metals and amyloid-beta in Alzheimer's disease.
International journal of experimental pathology 2005;86(3):147-59.
2005: Chris Frederickson; Jae-Young Koh; Ashley I Bush
The neurobiology of zinc in health and disease.
Nature reviews. Neuroscience 2005;6(6):449-62.
2005: Feda E Ali; Frances Separovic; Colin J Barrow; Robert A Cherny; Fiona Fraser; Ashley I Bush; Colin L Masters; Kevin J Barnham
Methionine regulates copper/hydrogen peroxide oxidation products of Abeta.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(6):353-60.
2005: Anna K Tickler; Danielle G Smith; Giuseppe D Ciccotosto; Deborah J Tew; Cyril C Curtain; Darryl Carrington; Colin L Masters; Ashley I Bush; Robert A Cherny; Roberto Cappai; John D Wade; Kevin J Barnham
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
The Journal of biological chemistry 2005;280(14):13355-63.
2005: Stephanie Tucker; Michelle Ahl; Ashley I Bush; David Westaway; Xudong Huang; Jack T Rogers
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.
Current Alzheimer research 2005;2(2):249-54.
2005: Simon Melov; Norman Wolf; Dorothea Strozyk; Susan R Doctrow; Ashley I Bush
Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.
Free radical biology & medicine 2005;38(2):258-61.
2005: Math P Cuajungco; Christopher J Frederickson; Ashley I Bush
Amyloid-beta metal interaction and metal chelation.
Sub-cellular biochemistry 2005;38():235-54.
2004: Amanda Venti; Tony Giordano; Paul S Eder; Ashley I Bush; Debomoy K Lahiri; Nigel H Greig; Jack T Rogers
The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region.
Annals of the New York Academy of Sciences 2004;1035():34-48.
2004: Xudong Huang; Craig S Atwood; Robert D. Moir; Mariana A Hartshorn; Rudolph E Tanzi; Ashley I Bush
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):954-60.
2004: Craig W Ritchie; Ashley I Bush; Colin L Masters
Metal-protein attenuating compounds and Alzheimer's disease.
Expert opinion on investigational drugs 2004;13(12):1585-92.
2004: Alpaslan Dedeoglu; Kerry Cormier; Sandra M Payton; Katya A Tseitlin; Jonathan N Kremsky; Li Lai; Xiaohua Li; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush; Neil W Kowall; Jack T Rogers; Xudong Huang
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.
Experimental gerontology 2004;39(11-12):1641-9.
2004: Waldo Cerpa; María Inés Barría; Marcelo A Chacón; Miriam Suazo; Mauricio González; Carlos Opazo; Ashley I Bush; Nibaldo C Inestrosa
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1701-3.
2004: Giuseppe D Ciccotosto; Deborah J Tew; Cyril C Curtain; Danielle Smith; Darryl Carrington; Colin L Masters; Ashley I Bush; Robert A Cherny; Roberto Cappai; Kevin J Barnham
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
The Journal of biological chemistry 2004;279(41):42528-34.
2004: Mahmoud Kiaei; Ashley I Bush; BRETT MORRISON; John H Morrison; Robert A Cherny; Irene Volitakis; M Flint Beal; Jon W Gordon
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7945-50.
2004: Kevin J Barnham; Fredrik Haeffner; Giuseppe D Ciccotosto; Cyril C Curtain; Deborah J Tew; Christine Mavros; Konrad Beyreuther; Darryl Carrington; Colin L Masters; Robert A Cherny; Roberto Cappai; Ashley I Bush
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1427-9.
2004: D Allan Butterfield; Ashley I Bush
Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide.
Neurobiology of aging 2004;25(5):563-8.
2004: Ashley I Bush; Dorothea Strozyk
Serum copper: a biomarker for Alzheimer disease?
Archives of neurology 2004;61(5):631-2.
2004: Seiichi Nagano; Xudong Huang; Robert D. Moir; Sandra M Payton; Rudolph E Tanzi; Ashley I Bush
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
The Journal of biological chemistry 2004;279(15):14673-8.
2004: Shenggen Yao; Robert A Cherny; Ashley I Bush; Colin L Masters; Kevin J Barnham
Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(4):210-7.
2004: Anthony R White; Kevin J Barnham; Xudong Huang; Irene Voltakis; Konrad Beyreuther; Colin L Masters; Robert A Cherny; Ashley I Bush; Roberto Cappai
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):269-80.
2004: Avi Friedlich; Joo-Yong Lee; Thomas van Groen; Robert A Cherny; Irene Volitakis; Toby B Cole; Richard D Palmiter; Jae-Young Koh; Ashley I Bush
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(13):3453-9.
2004: Joo-Yong Lee; Jung-Hwan Kim; Seok Ho Hong; Ji Yoon Lee; Robert A Cherny; Ashley I Bush; Richard D Palmiter; Jae-Young Koh
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain.
The Journal of biological chemistry 2004;279(10):8602-7.
2004: Xudong Huang; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush; Jack T Rogers
Redox-active metals, oxidative stress, and Alzheimer's disease pathology.
Annals of the New York Academy of Sciences 2004;1012():153-63.
2004: Kevin J Barnham; Colin L Masters; Ashley I Bush
Neurodegenerative diseases and oxidative stress.
Nature reviews. Drug discovery 2004;3(3):205-14.
2004: Craig S Atwood; George Perry; Hong Zeng; Yoji Kato; Walton D Jones; Ke-Qing Ling; Xudong Huang; Robert D. Moir; Dandan Wang; Lawrence M Sayre; Mark A. Smith; Shu G Chen; Ashley I Bush
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.
Biochemistry 2004;43(2):560-8.
2003: Craig W Ritchie; Ashley I Bush; Andrew Mackinnon; Stephen Macfarlane; Maree Mastwyk; Lachlan MacGregor; Lyn Kiers; Robert A Cherny; Qiao-Xin Li; Amanda Tammer; Darryl Carrington; Christine Mavros; Irene Volitakis; Michel E Xilinas; David Ames; Stephen Davis; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
2003: Kevin J Barnham; Giuseppe D Ciccotosto; Anna K Tickler; Feda E Ali; Danielle G Smith; Nicholas A Williamson; Yuen-Han Lam; Darryl Carrington; Deborah J Tew; Gulcan Kocak; Irene Volitakis; Frances Separovic; Colin J Barrow; John D Wade; Colin L Masters; Robert A Cherny; Cyril C Curtain; Ashley I Bush; Roberto Cappai
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
The Journal of biological chemistry 2003;278(44):42959-65.
2003: Ashley I Bush; Colin L Masters; Rudolph E Tanzi
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11193-4.
2003: Anne E Finefrock; Ashley I Bush; P Murali Doraiswamy
Current status of metals as therapeutic targets in Alzheimer's disease.
Journal of the American Geriatrics Society 2003;51(8):1143-8.
2003: Ashley I Bush
Copper, zinc, and the metallobiology of Alzheimer disease.
Alzheimer disease and associated disorders 2003;17(3):147-50.
2003: Lee E Goldstein; Julien A Muffat; Robert A Cherny; Robert D. Moir; Maria H Ericsson; Xudong Huang; Christine Mavros; Jennifer A Coccia; Kyle Y Faget; Karlotta A Fitch; Colin L Masters; Rudolph E Tanzi; Leo T Chylack; Ashley I Bush
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet 2003;361(9365):1258-65.
2003: Ashley I Bush
The metallobiology of Alzheimer's disease.
Trends in neurosciences 2003;26(4):207-14.
2003: Deepinder Kaur; Ferda Yantiri; Subramanian Rajagopalan; jyothi mallajosyula; Jun Qin Mo; Rapee Boonplueang; Veena Viswanath; Russell Jacobs; Lichuan Yang; M Flint Beal; Dino DiMonte; Irene Volitaskis; Lisa M Ellerby; Robert A Cherny; Ashley I Bush; Julie K Andersen
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.
Neuron 2003;37(6):899-909.
2003: Cyril C Curtain; Feda E Ali; Danielle G Smith; Ashley I Bush; Colin L Masters; Kevin J Barnham
Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid.
The Journal of biological chemistry 2003;278(5):2977-82.
2002: Christa Maynard; Roberto Cappai; Irene Volitakis; Robert A Cherny; Anthony R White; Konrad Beyreuther; Colin L Masters; Ashley I Bush; Qiao-Xin Li
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.
The Journal of biological chemistry 2002;277(47):44670-6.
2002: Jack T Rogers; Jeffrey D Randall; Catherine M Cahill; Paul S Eder; Xudong Huang; Hiromi Gunshin; Lorene Leiter; Jay McPhee; Satinder S Sarang; Tada Utsuki; Nigel H Greig; Debomoy K Lahiri; Rudolph E Tanzi; Ashley I Bush; Tony Giordano; Steven R Gullans
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
The Journal of biological chemistry 2002;277(47):45518-28.
2002: Ashley I Bush
Metal complexing agents as therapies for Alzheimer's disease.
Neurobiology of aging 2002;23(6):1031-8.
2002: Carlos Opazo; Xudong Huang; Robert A Cherny; Robert D. Moir; Alex Roher; Anthony R White; Roberto Cappai; Colin L Masters; Rudolph E Tanzi; Nibaldo C Inestrosa; Ashley I Bush
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
The Journal of biological chemistry 2002;277(43):40302-8.
2002: Ashley I Bush
Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
Nature neuroscience 2002;5(10):919; author reply 919-20.
2002: Jack T Rogers; Jeffrey D Randall; Paul S Eder; Xudong Huang; Ashley I Bush; Rudolph E Tanzi; Amanda Venti; Sandra M Payton; Tony Giordano; Seiichi Nagano; Catherine M Cahill; Robert D. Moir; Debomoy K Lahiri; Nigel H Greig; Satinder S Sarang; Steven R Gullans
Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.
Journal of molecular neuroscience : MN 2002;19(1-2):77-82.
2002: Ashley I Bush; Rudolph E Tanzi
The galvanization of beta-amyloid in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7317-9.
2001: Michael Makdissi; Alexander Collie; Paul Maruff; David G Darby; Ashley I Bush; Paul McCrory; Kim Bennell
Computerised cognitive assessment of concussed Australian Rules footballers.
British journal of sports medicine 2001;35(5):354-60.
2001: Christopher J Frederickson; Ashley I Bush
Synaptically released zinc: physiological functions and pathological effects.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2001;14(3-4):353-66.
2001: Michael F Jobling; Xudong Huang; Leanne R Stewart; Kevin J Barnham; Cyril C Curtain; Irene Volitakis; Matthew A Perugini; Anthony R White; Robert A Cherny; Colin L Masters; Colin J Barrow; Steven J Collins; Ashley I Bush; Roberto Cappai
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
Biochemistry 2001;40(27):8073-84.
2001: Cyril C Curtain; F Ali; Irene Volitakis; Robert A Cherny; Raymond S Norton; Konrad Beyreuther; Colin J Barrow; Colin L Masters; Ashley I Bush; Kevin J Barnham
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
The Journal of biological chemistry 2001;276(23):20466-73.
2001: Robert A Cherny; Craig S Atwood; Michel E Xilinas; D N Gray; Walton D Jones; Catriona A McLean; Kevin J Barnham; Irene Volitakis; Fiona Fraser; Y Kim; Xudong Huang; Lee E Goldstein; Robert D. Moir; JT Lim; Konrad Beyreuther; Hui Zheng; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2001: Anthony R White; Xudong Huang; Michael F Jobling; Colin J Barrow; Konrad Beyreuther; Colin L Masters; Ashley I Bush; Roberto Cappai
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways.
Journal of neurochemistry 2001;76(5):1509-20.
2001: Catherine A Rottkamp; Arun K Raina; Xiongwei Zhu; E Gaier; Ashley I Bush; Craig S Atwood; M Chevion; George Perry; Mark A. Smith
Redox-active iron mediates amyloid-beta toxicity.
Free radical biology & medicine 2001;30(4):447-50.
2001: Ashley I Bush; Lee E Goldstein
Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts.
Novartis Foundation symposium 2001;235():26-38; discussion 38-43.
2000: Craig S Atwood; RC Scarpa; Xudong Huang; Robert D. Moir; Walton D Jones; D P Fairlie; Rudolph E Tanzi; Ashley I Bush
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42.
Journal of neurochemistry 2000;75(3):1219-33.
2000: Ole A Andreassen; Alpaslan Dedeoglu; Peter Klivenyi; M Flint Beal; Ashley I Bush
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis.
Neuroreport 2000;11(11):2491-3.
2000: T Lynch; Robert A Cherny; Ashley I Bush
Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions.
Experimental gerontology 2000;35(4):445-51.
2000: Math P Cuajungco; Lee E Goldstein; Akihiko Nunomura; Mark A. Smith; JT Lim; Craig S Atwood; Xudong Huang; Y W Farrag; George Perry; Ashley I Bush
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.
The Journal of biological chemistry 2000;275(26):19439-42.
2000: Lee E Goldstein; M C Leopold; Xudong Huang; Craig S Atwood; Aleister J Saunders; Mariana A Hartshorn; JT Lim; K Y Faget; J A Muffat; RC Scarpa; Leo T Chylack; E F Bowden; Rudolph E Tanzi; Ashley I Bush
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Biochemistry 2000;39(24):7266-75.
2000: Robert A Cherny; Kevin J Barnham; T Lynch; Irene Volitakis; Qiao-Xin Li; Catriona A McLean; Gerd Multhaup; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
2000: Craig S Atwood; Xudong Huang; Ashok Khatri; RC Scarpa; Y S Kim; Robert D. Moir; Rudolph E Tanzi; Alex Roher; Ashley I Bush
Copper catalyzed oxidation of Alzheimer Abeta.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):777-83.
2000: Xudong Huang; Math P Cuajungco; Craig S Atwood; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
Alzheimer's disease, beta-amyloid protein and zinc.
The Journal of nutrition 2000;130(5S Suppl):1488S-92S.
2000: Ashley I Bush
Metals and neuroscience.
Current opinion in chemical biology 2000;4(2):184-91.
2000: Math P Cuajungco; K Y Fagét; Xudong Huang; Rudolph E Tanzi; Ashley I Bush
Metal chelation as a potential therapy for Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;920():292-304.
1999: Xudong Huang; Math P Cuajungco; Craig S Atwood; Mariana A Hartshorn; J D Tyndall; G R Hanson; K C Stokes; M Leopold; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Aleister J Saunders; J Lim; Robert D. Moir; C Glabe; E F Bowden; Colin L Masters; D P Fairlie; Rudolph E Tanzi; Ashley I Bush
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
The Journal of biological chemistry 1999;274(52):37111-6.
1999: Catriona A McLean; Robert A Cherny; Fiona Fraser; Stephanie J Fuller; M J Smith; Konrad Beyreuther; Ashley I Bush; Colin L Masters
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
Annals of neurology 1999;46(6):860-6.
1999: Anthony R White; Gerd Multhaup; Fran Maher; Shayne A Bellingham; James Camakaris; Hui Zheng; Ashley I Bush; Konrad Beyreuther; Colin L Masters; Roberto Cappai
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9170-9.
1999: Anthony R White; R Reyes; Julian F B Mercer; James Camakaris; Hui Zheng; Ashley I Bush; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
Brain research 1999;842(2):439-44.
1999: Robert A Cherny; J T Legg; Catriona A McLean; D P Fairlie; Xudong Huang; Craig S Atwood; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
The Journal of biological chemistry 1999;274(33):23223-8.
1999: Robert D. Moir; Craig S Atwood; Xudong Huang; Rudolph E Tanzi; Ashley I Bush
Mounting evidence for the involvement of zinc and copper in Alzheimer's disease.
European journal of clinical investigation 1999;29(7):569-70.
1999: Xudong Huang; Craig S Atwood; Mariana A Hartshorn; Gerd Multhaup; Lee E Goldstein; RC Scarpa; Math P Cuajungco; D N Gray; J Lim; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Biochemistry 1999;38(24):7609-16.
1999: Qiao-Xin Li; C Maynard; Roberto Cappai; Catriona A McLean; Robert A Cherny; T Lynch; Janetta G Culvenor; J Trevaskis; JE Tanner; K A Bailey; C Czech; Ashley I Bush; Konrad Beyreuther; Colin L Masters
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.
Journal of neurochemistry 1999;72(6):2479-87.
1999: Anthony R White; Ashley I Bush; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.
Journal of neurochemistry 1999;72(5):2092-8.
1999: Robert D. Moir; Craig S Atwood; Donna M Romano; M H Laurans; Xudong Huang; Ashley I Bush; Jonathan D. Smith; Rudolph E Tanzi
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
Biochemistry 1999;38(14):4595-603.
1999: Craig S Atwood; Xudong Huang; Robert D. Moir; Rudolph E Tanzi; Ashley I Bush
Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease.
Metal ions in biological systems 1999;36():309-64.
1998: Benjamin Wolozin; S Maheshwari; C Jones; RA Dukoff; W Wallace; Marco Racchi; S Nagula; N R Shulman; Trey Sunderland; Ashley I Bush
Beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants.
Molecular psychiatry 1998;3(6):500-7.
1998: Ashley I Bush; Rudolph E Tanzi
Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery?
Archives of neurology 1998;55(9):1179-80.
1998: Craig S Atwood; Robert D. Moir; Xudong Huang; RC Scarpa; N M Bacarra; Donna M Romano; Mariana A Hartshorn; Rudolph E Tanzi; Ashley I Bush
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
The Journal of biological chemistry 1998;273(21):12817-26.
1998: Robert D. Moir; T Lynch; Ashley I Bush; S Whyte; A Henry; S Portbury; Gerd Multhaup; David Small; Rudolph E Tanzi; Konrad Beyreuther; Colin L Masters
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
1998: Christoph Hock; S Golombowski; Franz Müller-Spahn; W Naser; Konrad Beyreuther; U Mönning; Dale Schenk; C Vigo-Pelfrey; Ashley I Bush; Robert D. Moir; Rudolph E Tanzi; John H Growdon; Roger M Nitsch
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
European neurology 1998;39(2):111-8.
1997: Xudong Huang; Craig S Atwood; Robert D. Moir; Mariana A Hartshorn; J P Vonsattel; Rudolph E Tanzi; Ashley I Bush
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.
The Journal of biological chemistry 1997;272(42):26464-70.
1997: Michael Aschner; M G Cherian; C D Klaassen; R D Palmiter; J C Erickson; Ashley I Bush
Metallothioneins in brain--the role in physiology and pathology.
Toxicology and applied pharmacology 1997;142(2):229-42.
1995: M Z Kounnas; Robert D. Moir; G. William Rebeck; Ashley I Bush; Scott Argraves; Rudolph E Tanzi; Bradley T Hyman; Dudley K Strickland
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
1995: Ashley I Bush; R D Moir; K M Rosenkranz; Rudolph E Tanzi
Response.
Science (New York, N.Y.) 1995;268(5219):1921-3.
1994: Gerd Multhaup; Ashley I Bush; P Pollwein; Colin L Masters
Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).
FEBS letters 1994;355(2):151-4.
1994: Ashley I Bush; Warren H Pettingell; M de Paradis; Rudolph E Tanzi; Wilma Wasco
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.
The Journal of biological chemistry 1994;269(43):26618-21.
1994: Ashley I Bush; Warren H Pettingell; Gerd Multhaup; M d Paradis; J P Vonsattel; James Gusella; Konrad Beyreuther; Colin L Masters; Rudolph E Tanzi
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
1994: Qiao-Xin Li; M C Berndt; Ashley I Bush; B Rumble; I Mackenzie; Anna Friedhuber; Konrad Beyreuther; Colin L Masters
Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet.
Blood 1994;84(1):133-42.
1994: Ashley I Bush; Warren H Pettingell; M D Paradis; Rudolph E Tanzi
Modulation of A beta adhesiveness and secretase site cleavage by zinc.
The Journal of biological chemistry 1994;269(16):12152-8.
1994: Rudolph E Tanzi; Ashley I Bush; Wilma Wasco
Genetic studies of Alzheimer's disease: lessons learned and future imperatives.
Neurobiology of aging 1994;15 Suppl 2():S145-8.
1993: Ashley I Bush; Konrad Beyreuther; Colin L Masters
The beta A4 amyloid protein precursor in human circulation.
Annals of the New York Academy of Sciences 1993;695():175-82.
1993: Ashley I Bush; Gerd Multhaup; Robert D. Moir; T G Williamson; David Small; B Rumble; P Pollwein; Konrad Beyreuther; Colin L Masters
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
The Journal of biological chemistry 1993;268(22):16109-12.
1993: Rudolph E Tanzi; S Gaston; Ashley I Bush; Donna M Romano; W Pettingell; J Peppercorn; M Paradis; S Gurubhagavatula; B Jenkins; Wilma Wasco
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.
Genetica 1993;91(1-3):255-63.
1992: Robert D. Moir; Ralph N Martins; Ashley I Bush; David Small; E A Milward; B A Rumble; Gerd Multhaup; Konrad Beyreuther; Colin L Masters
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.
Journal of neurochemistry 1992;59(4):1490-8.
1992: Ashley I Bush; S Whyte; L D Thomas; T G Williamson; C J Van Tiggelen; Jon Currie; David Small; Robert D. Moir; Qiao-Xin Li; B Rumble
An abnormality of plasma amyloid protein precursor in Alzheimer's disease.
Annals of neurology 1992;32(1):57-65.
1992: Ashley I Bush; Konrad Beyreuther; Colin L Masters
Beta A4 amyloid protein and its precursor in Alzheimer's disease.
Pharmacology & therapeutics 1992;56(1):97-117.
1991: David Small; Robert D. Moir; S J Fuller; S Michaelson; Ashley I Bush; Qiao-Xin Li; E Milward; C Hilbich; A Weidemann; Konrad Beyreuther
A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease.
Biochemistry 1991;30(44):10795-9.
1991: Konrad Beyreuther; Ashley I Bush; T Dyrks; C Hilbich; G König; U Mönning; Gerd Multhaup; R Prior; B Rumble; W Schubert
Mechanisms of amyloid deposition in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():129-39.
1990: Ashley I Bush; Ralph N Martins; B Rumble; Robert D. Moir; S Fuller; E Milward; Jon Currie; D Ames; A Weidemann; P Fischer
The amyloid precursor protein of Alzheimer's disease is released by human platelets.
The Journal of biological chemistry 1990;265(26):15977-83.
1990: Ashley I Bush; W Huang; D L Copolov; A T Lim
Hypothalamic atrial natriuretic peptide secretion plasticity: differential modulation of alpha and beta adrenoceptors.
Neuroendocrinology 1990;52(1):65-9.