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Ashley Bush
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Disorders
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49
Masters, Colin
37
Tanzi, Rudolph
36
Cherny, Robert
30
Huang, Xudong
27
Moir, Robert D.
25
Volitakis, Irene
24
Barnham, Kevin
24
Beyreuther, Konrad
20
Cappai, Roberto
17
Atwood, Craig
17
Li, Qiao-Xin
15
White, Anthony
11
Multhaup, Gerd
9
Curtain, Cyril
8
Goldstein, Lee
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All Publications
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2009: Sensi Stefano L; Paoletti Pierre; Bush Ashley I; Sekler Israel
Zinc in the physiology and pathology of the CNS.
Nature reviews. Neuroscience 2009;10(11):780-91.
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2009: McColl Gawain; Roberts Blaine R; Gunn Adam P; Perez Keyla A; Tew Deborah J; Masters Colin L; Barnham Kevin J; Cherny Robert A; Bush Ashley I
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.
The Journal of biological chemistry 2009;284(34):22697-702.
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2009: Hung Ya Hui; Robb Elysia L; Volitakis Irene; Ho Michael; Evin Genevieve; Li Qiao-Xin; Culvenor Janetta G; Masters Colin L; Cherny Robert A; Bush Ashley I
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.
The Journal of biological chemistry 2009;284(33):21899-907.
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2009: Ellis Kathryn A; Bush Ashley I; Darby David; De Fazio Daniela; Foster Jonathan; Hudson Peter; Lautenschlager Nicola T; Lenzo Nat; Martins Ralph N; Maruff Paul; Masters Colin; Milner Andrew; Pike Kerryn; Rowe Christopher; Savage Greg; Szoeke Cassandra; Taddei Kevin; Villemagne Victor; Woodward Michael; Ames David;
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease.
International psychogeriatrics / IPA 2009;21(4):672-87.
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2009: Maynard Christa J; Cappai Roberto; Volitakis Irene; Laughton Katrina M; Masters Colin L; Bush Ashley I; Li Qiao-Xin
Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice.
Cellular and molecular neurobiology 2009;29(5):757-67.
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2009: Strozyk Dorothea; Launer Lenore J; Adlard Paul A; Cherny Robert A; Tsatsanis Andrew; Volitakis Irene; Blennow Kaj; Petrovitch Helen; White Lon R; Bush Ashley I
Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.
Neurobiology of aging 2009;30(7):1069-77.
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2009: White Carine; Kambe Taiho; Fulcher Yan G; Sachdev Sherri W; Bush Ashley I; Fritsche Kevin; Lee Jaekwon; Quinn Thomas P; Petris Michael J
Copper transport into the secretory pathway is regulated by oxygen in macrophages.
Journal of cell science 2009;122(Pt 9):1315-21.
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2009: Adlard Paul A; James Simon A; Bush Ashley I; Masters Colin L
beta-Amyloid as a molecular therapeutic target in Alzheimer's disease.
Drugs of today (Barcelona, Spain : 1998) 2009;45(4):293-304.
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2009: Grasso Giuseppe; Bush Ashley I; D'Agata Roberta; Rizzarelli Enrico; Spoto Giuseppe
Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme.
European biophysics journal : EBJ 2009;38(4):407-14.
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2009: George J L; Mok S; Moses D; Wilkins S; Bush A I; Cherny R A; Finkelstein D I
Targeting the progression of Parkinson's disease.
Current neuropharmacology 2009;7(1):9-36.
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2009: Dean Olivia; Bush Ashley I; Berk Michael; Copolov David L; van den Buuse Maarten
Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice.
Behavioural brain research 2009;198(1):258-62.
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2009: Crouch Peter J; Hung Lin Wai; Adlard Paul A; Cortes Mikhalina; Lal Varsha; Filiz Gulay; Perez Keyla A; Nurjono Milawaty; Caragounis Aphrodite; Du Tai; Laughton Katrina; Volitakis Irene; Bush Ashley I; Li Qiao-Xin; Masters Colin L; Cappai Roberto; Cherny Robert A; Donnelly Paul S; White Anthony R; Barnham Kevin J
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):381-6.
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2009: Biran Yif'at; Masters Colin L; Barnham Kevin J; Bush Ashley I; Adlard Paul A
Pharmacotherapeutic targets in Alzheimer's disease.
Journal of cellular and molecular medicine 2009;13(1):61-86.
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2009: Smidt Kamille; Jessen Niels; Petersen Andreas Brønden; Larsen Agnete; Magnusson Nils; Jeppesen Johanne Bruun; Stoltenberg Meredin; Culvenor Janetta G; Tsatsanis Andrew; Brock Birgitte; Schmitz Ole; Wogensen Lise; Bush Ashley I; Rungby Jørgen
SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.
PloS one 2009;4(5):e5684.
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2008: Rogers Jack T; Bush Ashley I; Cho Hyan-Hee; Smith Deborah H; Thomson Andrew M; Friedlich Avi L; Lahiri Debomoy K; Leedman Peter J; Huang Xudong; Cahill Catherine M
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.
Biochemical Society transactions 2008;36(Pt 6):1282-7.
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2008: Wu Wei-hui; Lei Peng; Liu Qian; Hu Jia; Gunn Adam P; Chen Mei-sha; Rui Yan-fang; Su Xiao-yang; Xie Zuo-ping; Zhao Yu-Fen; Bush Ashley I; Li Yan-mei
Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents.
The Journal of biological chemistry 2008;283(46):31657-64.
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2008: Bush Ashley I
Drug development based on the metals hypothesis of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2008;15(2):223-40.
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2008: Lannfelt Lars; Blennow Kaj; Zetterberg Henrik; Batsman Stellan; Ames David; Harrison John; Masters Colin L; Targum Steve; Bush Ashley I; Murdoch Ross; Wilson Janet; Ritchie Craig W;
Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.
Lancet neurology 2008;7(9):779-86.
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2008: Berk Michael; Copolov David L; Dean Olivia; Lu Kristy; Jeavons Sue; Schapkaitz Ian; Anderson-Hunt Murray; Bush Ashley I
N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial.
Biological psychiatry 2008;64(6):468-75.
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2008: Berk Michael; Copolov David; Dean Olivia; Lu Kristy; Jeavons Sue; Schapkaitz Ian; Anderson-Hunt Murray; Judd Fiona; Katz Fiona; Katz Paul; Ording-Jespersen Sean; Little John; Conus Philippe; Cuenod Michel; Do Kim Q; Bush Ashley I
N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial.
Biological psychiatry 2008;64(5):361-8.
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2008: Ng Felicity; Berk Michael; Dean Olivia; Bush Ashley I
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2008;11(6):851-76.
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2008: Lavoie Suzie; Murray Micah M; Deppen Patricia; Knyazeva Maria G; Berk Michael; Boulat Olivier; Bovet Pierre; Bush Ashley I; Conus Philippe; Copolov David; Fornari Eleonora; Meuli Reto; Solida Alessandra; Vianin Pascal; Cuénod Michel; Buclin Thierry; Do Kim Q
Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(9):2187-99.
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2008: Bush Ashley I; Tanzi Rudolph E
Therapeutics for Alzheimer's disease based on the metal hypothesis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):421-32.
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2008: Adlard Paul A; Cherny Robert A; Finkelstein David I; Gautier Elisabeth; Robb Elysia; Cortes Mikhalina; Volitakis Irene; Liu Xiang; Smith Jeffrey P; Perez Keyla; Laughton Katrina; Li Qiao-Xin; Charman Susan A; Nicolazzo Joseph A; Wilkins Simon; Deleva Karolina; Lynch Toni; Kok Gaik; Ritchie Craig W; Tanzi Rudolph E; Cappai Roberto; Masters Colin L; Barnham Kevin J; Bush Ashley I
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Neuron 2008;59(1):43-55.
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2008: Berk Michael; Ng Felicity; Dean Olivia; Dodd Seetal; Bush Ashley I
Glutathione: a novel treatment target in psychiatry.
Trends in pharmacological sciences 2008;29(7):346-51.
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2008: Barnham Kevin J; Kenche Vijaya B; Ciccotosto Giuseppe D; Smith David P; Tew Deborah J; Liu Xiang; Perez Keyla; Cranston Greg A; Johanssen Timothy J; Volitakis Irene; Bush Ashley I; Masters Colin L; White Anthony R; Smith Jeffrey P; Cherny Robert A; Cappai Roberto
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6813-8.
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2008: Du Tai; La Fontaine Sharon L; Abdo Michael; Bellingham Shayne A; Greenough Mark; Volitakis Irene; Cherny Robert A; Bush Ashley I; Hudson Peter J; Camakaris James; Mercer Julian F; Crouch Peter J; Masters Colin L; Perreau Victoria M; White Anthony R
Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays.
Proteomics 2008;8(9):1819-31.
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2008: Cater Michael A; McInnes Kelly T; Li Qiao-Xin; Volitakis Irene; La Fontaine Sharon; Mercer Julian F B; Bush Ashley I
Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
The Biochemical journal 2008;412(1):141-52.
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2008: Barnham Kevin J; Bush Ashley I
Metals in Alzheimer's and Parkinson's diseases.
Current opinion in chemical biology 2008;12(2):222-8.
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2008: Colvin Robert A; Bush Ashley I; Volitakis Irene; Fontaine Charles P; Thomas Dustin; Kikuchi Kazuya; Holmes William R
Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.
American journal of physiology. Cell physiology 2008;294(3):C726-42.
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2008: Bush Ashley I; Curtain Cyril C
Twenty years of metallo-neurobiology: where to now?
European biophysics journal : EBJ 2008;37(3):241-5.
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2008: Nagano Seiichi; Bush Ashley I
Sensitive, selective, and irreversible inhibition of cyclooxygenase-2 activity by copper.
ChemMedChem 2008;3(2):223-5.
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2008: Crouch Peter J; Harding Susan-Marie E; White Anthony R; Camakaris James; Bush Ashley I; Masters Colin L
Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease.
The international journal of biochemistry & cell biology 2008;40(2):181-98.
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2007: Stoltenberg M; Bush A I; Bach G; Smidt K; Larsen A; Rungby J; Lund S; Doering P; Danscher G
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency.
Neuroscience 2007;150(2):357-69.
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2007: Crouch P J; Cimdins K; Duce J A; Bush A I; Trounce I A
Mitochondria in aging and Alzheimer's disease.
Rejuvenation research 2007;10(3):349-57.
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2007: Crouch Peter J; White Anthony R; Bush Ashley I
The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
The FEBS journal 2007;274(15):3775-83.
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2007: Watanabe Shohei; Nagano Seiichi; Duce James; Kiaei Mahmoud; Li Qiao-Xin; Tucker Stephanie M; Tiwari Ashutosh; Brown Robert H; Beal M Flint; Hayward Lawrence J; Culotta Valeria C; Yoshihara Satoshi; Sakoda Saburo; Bush Ashley I
Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.
Free radical biology & medicine 2007;42(10):1534-42.
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2007: Melov Simon; Adlard Paul A; Morten Karl; Johnson Felicity; Golden Tamara R; Hinerfeld Doug; Schilling Birgit; Mavros Christine; Masters Colin L; Volitakis Irene; Li Qiao-Xin; Laughton Katrina; Hubbard Alan; Cherny Robert A; Gibson Brad; Bush Ashley I
Mitochondrial oxidative stress causes hyperphosphorylation of tau.
PloS one 2007;2(6):e536.
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2007: Fox Jonathan H; Kama Jibrin A; Lieberman Gregory; Chopra Raman; Dorsey Kate; Chopra Vanita; Volitakis Irene; Cherny Robert A; Bush Ashley I; Hersch Steven
Mechanisms of copper ion mediated Huntington's disease progression.
PloS one 2007;2(3):e334.
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2006: Adlard Paul A; Bush Ashley I
Metals and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;10(2-3):145-63.
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2006: Crouch Peter J; Barnham Kevin J; Bush Ashley I; White Anthony R
Therapeutic treatments for Alzheimer's disease based on metal bioavailability.
Drug news & perspectives 2006;19(8):469-74.
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2006: Tucker Stephanie; Ahl Michelle; Cho Hyun-Hee; Bandyopadhyay Sanghamitra; Cuny Gregory D; Bush Ashley I; Goldstein Lee E; Westaway David; Huang Xudong; Rogers Jack T
RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.
Current Alzheimer research 2006;3(3):221-7.
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2006: Religa D; Strozyk D; Cherny R A; Volitakis I; Haroutunian V; Winblad B; Naslund J; Bush A I
Elevated cortical zinc in Alzheimer disease.
Neurology 2006;67(1):69-75.
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2006: White Anthony R; Du Tai; Laughton Katrina M; Volitakis Irene; Sharples Robyn A; Xilinas Michel E; Hoke David E; Holsinger R M Damian; Evin Geneviève; Cherny Robert A; Hill Andrew F; Barnham Kevin J; Li Qiao-Xin; Bush Ashley I; Masters Colin L
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
The Journal of biological chemistry 2006;281(26):17670-80.
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2006: Smith David P; Smith Danielle G; Curtain Cyril C; Boas John F; Pilbrow John R; Ciccotosto Giuseppe D; Lau Tong-Lay; Tew Deborah J; Perez Keyla; Wade John D; Bush Ashley I; Drew Simon C; Separovic Frances; Masters Colin L; Cappai Roberto; Barnham Kevin J
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
The Journal of biological chemistry 2006;281(22):15145-54.
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2006: White Anthony R; Barnham Kevin J; Bush Ashley I
Metal homeostasis in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(5):711-22.
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2006: Maynard Christa J; Cappai Roberto; Volitakis Irene; Cherny Robert A; Masters Colin L; Li Qiao-Xin; Bush Ashley I
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.
Journal of inorganic biochemistry 2006;100(5-6):952-62.
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2006: Opazo Carlos; Luza Sandra; Villemagne Victor L; Volitakis Irene; Rowe Christopher; Barnham Kevin J; Strozyk Dorothea; Masters Colin L; Cherny Robert A; Bush Ashley I
Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
Aging cell 2006;5(1):69-79.
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2005: Haeffner Fredrik; Smith Danielle G; Barnham Kevin J; Bush Ashley I
Model studies of cholesterol and ascorbate oxidation by copper complexes: relevance to Alzheimer's disease beta-amyloid metallochemistry.
Journal of inorganic biochemistry 2005;99(12):2403-22.
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2005: Siddiq Ambreena; Ayoub Issam A; Chavez Juan C; Aminova Leila; Shah Sapan; LaManna Joseph C; Patton Stephanie M; Connor James R; Cherny Robert A; Volitakis Irene; Bush Ashley I; Langsetmo Ingrid; Seeley Todd; Gunzler Volkmar; Ratan Rajiv R
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
The Journal of biological chemistry 2005;280(50):41732-43.
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2005: Puglielli Luigi; Friedlich Avi L; Setchell Kenneth D R; Nagano Seiichi; Opazo Carlos; Cherny Robert A; Barnham Kevin J; Wade John D; Melov Simon; Kovacs Dora M; Bush Ashley I
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
The Journal of clinical investigation 2005;115(9):2556-63.
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2005: Maynard Christa J; Bush Ashley I; Masters Colin L; Cappai Roberto; Li Qiao-Xin
Metals and amyloid-beta in Alzheimer's disease.
International journal of experimental pathology 2005;86(3):147-59.
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2005: Frederickson Christopher J; Koh Jae-Young; Bush Ashley I
The neurobiology of zinc in health and disease.
Nature reviews. Neuroscience 2005;6(6):449-62.
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2005: Ali Feda E; Separovic Frances; Barrow Colin J; Cherny Robert A; Fraser Fiona; Bush Ashley I; Masters Colin L; Barnham Kevin J
Methionine regulates copper/hydrogen peroxide oxidation products of Abeta.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(6):353-60.
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2005: Tucker Stephanie; Ahl Michelle; Bush Ashley; Westaway David; Huang Xudong; Rogers Jack T
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.
Current Alzheimer research 2005;2(2):249-54.
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2005: Tickler Anna K; Smith Danielle G; Ciccotosto Giuseppe D; Tew Deborah J; Curtain Cyril C; Carrington Darryl; Masters Colin L; Bush Ashley I; Cherny Robert A; Cappai Roberto; Wade John D; Barnham Kevin J
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
The Journal of biological chemistry 2005;280(14):13355-63.
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2005: Melov Simon; Wolf Norman; Strozyk Dorothea; Doctrow Susan R; Bush Ashley I
Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.
Free radical biology & medicine 2005;38(2):258-61.
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2005: Cuajungco Math P; Frederickson Christopher J; Bush Ashley I
Amyloid-beta metal interaction and metal chelation.
Sub-cellular biochemistry 2005;38():235-54.
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2004: Venti Amanda; Giordano Tony; Eder Paul; Bush Ashley I; Lahiri Debomoy K; Greig Nigel H; Rogers Jack T
The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region.
Annals of the New York Academy of Sciences 2004;1035():34-48.
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2004: Huang Xudong; Atwood Craig S; Moir Robert D; Hartshorn Mariana A; Tanzi Rudolph E; Bush Ashley I
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):954-60.
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2004: Ritchie Craig W; Bush Ashley I; Masters Colin L
Metal-protein attenuating compounds and Alzheimer's disease.
Expert opinion on investigational drugs 2004;13(12):1585-92.
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2004: Dedeoglu Alpaslan; Cormier Kerry; Payton Sandra; Tseitlin Katya A; Kremsky Jonathan N; Lai Li; Li Xiaohua; Moir Robert D; Tanzi Rudolph E; Bush Ashley I; Kowall Neil W; Rogers Jack T; Huang Xudong
Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.
Experimental gerontology 2004;39(11-12):1641-9.
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2004: Cerpa Waldo F; Barría María I; Chacón Marcelo A; Suazo Miriam; González Mauricio; Opazo Carlos; Bush Ashley I; Inestrosa Nibaldo C
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1701-3.
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2004: Ciccotosto Giuseppe D; Tew Deborah; Curtain Cyril C; Smith Danielle; Carrington Darryl; Masters Colin L; Bush Ashley I; Cherny Robert A; Cappai Roberto; Barnham Kevin J
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
The Journal of biological chemistry 2004;279(41):42528-34.
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2004: Kiaei Mahmoud; Bush Ashley I; Morrison Brett M; Morrison John H; Cherny Robert A; Volitakis Irene; Beal M Flint; Gordon Jon W
Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7945-50.
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2004: Barnham Kevin J; Haeffner Fredrik; Ciccotosto Giuseppe D; Curtain Cyril C; Tew Deborah; Mavros Christine; Beyreuther Konrad; Carrington Darryl; Masters Colin L; Cherny Robert A; Cappai Roberto; Bush Ashley I
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1427-9.
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2004: Butterfield D Allan; Bush Ashley I
Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide.
Neurobiology of aging 2004;25(5):563-8.
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2004: Bush Ashley I; Strozyk Dorothea
Serum copper: a biomarker for Alzheimer disease?
Archives of neurology 2004;61(5):631-2.
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2004: Yao Shenggen; Cherny Robert A; Bush Ashley I; Masters Colin L; Barnham Kevin J
Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(4):210-7.
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2004: White Anthony R; Barnham Kevin J; Huang Xudong; Voltakis Irene; Beyreuther Konrad; Masters Colin L; Cherny Robert A; Bush Ashley I; Cappai Roberto
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):269-80.
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2004: Nagano Seiichi; Huang Xudong; Moir Robert D; Payton Sandra M; Tanzi Rudolph E; Bush Ashley I
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
The Journal of biological chemistry 2004;279(15):14673-8.
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2004: Huang Xudong; Moir Robert D; Tanzi Rudolph E; Bush Ashley I; Rogers Jack T
Redox-active metals, oxidative stress, and Alzheimer's disease pathology.
Annals of the New York Academy of Sciences 2004;1012():153-63.
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2004: Friedlich Avi L; Lee Joo-Yong; van Groen Thomas; Cherny Robert A; Volitakis Irene; Cole Toby B; Palmiter Richard D; Koh Jae-Young; Bush Ashley I
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(13):3453-9.
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2004: Barnham Kevin J; Masters Colin L; Bush Ashley I
Neurodegenerative diseases and oxidative stress.
Nature reviews. Drug discovery 2004;3(3):205-14.
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2004: Lee Joo-Yong; Kim Jung-Hwan; Hong Seok Ho; Lee Ji Yoon; Cherny Robert A; Bush Ashley I; Palmiter Richard D; Koh Jae-Young
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain.
The Journal of biological chemistry 2004;279(10):8602-7.
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2004: Atwood Craig S; Perry George; Zeng Hong; Kato Yoji; Jones Walton D; Ling Ke-Qing; Huang Xudong; Moir Robert D; Wang Dandan; Sayre Lawrence M; Smith Mark A; Chen Shu G; Bush Ashley I
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.
Biochemistry 2004;43(2):560-8.
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2003: Ritchie Craig W; Bush Ashley I; Mackinnon Andrew; Macfarlane Steve; Mastwyk Maree; MacGregor Lachlan; Kiers Lyn; Cherny Robert; Li Qiao-Xin; Tammer Amanda; Carrington Darryl; Mavros Christine; Volitakis Irene; Xilinas Michel; Ames David; Davis Stephen; Beyreuther Konrad; Tanzi Rudolph E; Masters Colin L
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Archives of neurology 2003;60(12):1685-91.
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2003: Barnham Kevin J; Ciccotosto Giuseppe D; Tickler Anna K; Ali Feda E; Smith Danielle G; Williamson Nicholas A; Lam Yuen-Han; Carrington Darryl; Tew Deborah; Kocak Gulcan; Volitakis Irene; Separovic Frances; Barrow Colin J; Wade John D; Masters Colin L; Cherny Robert A; Curtain Cyril C; Bush Ashley I; Cappai Roberto
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
The Journal of biological chemistry 2003;278(44):42959-65.
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2003: Bush Ashley I; Masters Colin L; Tanzi Rudolph E
Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11193-4.
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2003: Finefrock Anne E; Bush Ashley I; Doraiswamy P Murali
Current status of metals as therapeutic targets in Alzheimer's disease.
Journal of the American Geriatrics Society 2003;51(8):1143-8.
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2003: Bush Ashley I
Copper, zinc, and the metallobiology of Alzheimer disease.
Alzheimer disease and associated disorders 2003;17(3):147-50.
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2003: Goldstein Lee E; Muffat Julien A; Cherny Robert A; Moir Robert D; Ericsson Maria H; Huang Xudong; Mavros Christine; Coccia Jennifer A; Faget Kyle Y; Fitch Karlotta A; Masters Colin L; Tanzi Rudolph E; Chylack Leo T; Bush Ashley I
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet 2003;361(9365):1258-65.
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2003: Bush Ashley I
The metallobiology of Alzheimer's disease.
Trends in neurosciences 2003;26(4):207-14.
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2003: Kaur Deepinder; Yantiri Ferda; Rajagopalan Subramanian; Kumar Jyothi; Mo Jun Qin; Boonplueang Rapee; Viswanath Veena; Jacobs Russell; Yang Lichuan; Beal M Flint; DiMonte Dino; Volitaskis Irene; Ellerby Lisa; Cherny Robert A; Bush Ashley I; Andersen Julie K
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.
Neuron 2003;37(6):899-909.
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2003: Curtain Cyril C; Ali Fedá E; Smith Danielle G; Bush Ashley I; Masters Colin L; Barnham Kevin J
Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid.
The Journal of biological chemistry 2003;278(5):2977-82.
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2002: Bush Ashley I
Metal complexing agents as therapies for Alzheimer's disease.
Neurobiology of aging 2002;23(6):1031-8.
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2002: Maynard Christa J; Cappai Roberto; Volitakis Irene; Cherny Robert A; White Anthony R; Beyreuther Konrad; Masters Colin L; Bush Ashley I; Li Qiao-Xin
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.
The Journal of biological chemistry 2002;277(47):44670-6.
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2002: Rogers Jack T; Randall Jeffrey D; Cahill Catherine M; Eder Paul S; Huang Xudong; Gunshin Hiromi; Leiter Lorene; McPhee Jay; Sarang Satinder S; Utsuki Tada; Greig Nigel H; Lahiri Debomoy K; Tanzi Rudolph E; Bush Ashley I; Giordano Tony; Gullans Steve R
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
The Journal of biological chemistry 2002;277(47):45518-28.
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2002: Bush Ashley I
Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?
Nature neuroscience 2002;5(10):919; author reply 919-20.
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2002: Opazo Carlos; Huang Xudong; Cherny Robert A; Moir Robert D; Roher Alex E; White Anthony R; Cappai Roberto; Masters Colin L; Tanzi Rudolph E; Inestrosa Nibaldo C; Bush Ashley I
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
The Journal of biological chemistry 2002;277(43):40302-8.
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2002: Rogers Jack T; Randall Jeffrey D; Eder Paul S; Huang Xudong; Bush Ashley I; Tanzi Rudolph E; Venti Amanda; Payton Sandra M; Giordano Tony; Nagano Seiichi; Cahill Catherine M; Moir Robert; Lahiri Debomoy K; Greig Nigel; Sarang Satinder Singh; Gullans Steven R
Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.
Journal of molecular neuroscience : MN 2002;19(1-2):77-82.
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2002: Bush Ashley I; Tanzi Rudolph E
The galvanization of beta-amyloid in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7317-9.
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2001: Frederickson C J; Bush A I
Synaptically released zinc: physiological functions and pathological effects.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2001;14(3-4):353-66.
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2001: Jobling M F; Huang X; Stewart L R; Barnham K J; Curtain C; Volitakis I; Perugini M; White A R; Cherny R A; Masters C L; Barrow C J; Collins S J; Bush A I; Cappai R
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
Biochemistry 2001;40(27):8073-84.
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2001: Cherny R A; Atwood C S; Xilinas M E; Gray D N; Jones W D; McLean C A; Barnham K J; Volitakis I; Fraser F W; Kim Y; Huang X; Goldstein L E; Moir R D; Lim J T; Beyreuther K; Zheng H; Tanzi R E; Masters C L; Bush A I
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
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2001: Curtain C C; Ali F; Volitakis I; Cherny R A; Norton R S; Beyreuther K; Barrow C J; Masters C L; Bush A I; Barnham K J
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
The Journal of biological chemistry 2001;276(23):20466-73.
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2001: White A R; Huang X; Jobling M F; Barrow C J; Beyreuther K; Masters C L; Bush A I; Cappai R
Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways.
Journal of neurochemistry 2001;76(5):1509-20.
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2001: Rottkamp C A; Raina A K; Zhu X; Gaier E; Bush A I; Atwood C S; Chevion M; Perry G; Smith M A
Redox-active iron mediates amyloid-beta toxicity.
Free radical biology & medicine 2001;30(4):447-50.
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2001: Bush A I; Goldstein L E
Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts.
Novartis Foundation symposium 2001;235():26-38; discussion 38-43.
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2000: Atwood C S; Scarpa R C; Huang X; Moir R D; Jones W D; Fairlie D P; Tanzi R E; Bush A I
Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42.
Journal of neurochemistry 2000;75(3):1219-33.
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2000: Andreassen O A; Dedeoglu A; Klivenyi P; Beal M F; Bush A I
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis.
Neuroreport 2000;11(11):2491-3.
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2000: Lynch T; Cherny R A; Bush A I
Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions.
Experimental gerontology 2000;35(4):445-51.
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2000: Cherny R A; Barnham K J; Lynch T; Volitakis I; Li Q X; McLean C A; Multhaup G; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Journal of structural biology 2000;130(2-3):209-16.
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2000: Atwood C S; Huang X; Khatri A; Scarpa R C; Kim Y S; Moir R D; Tanzi R E; Roher A E; Bush A I
Copper catalyzed oxidation of Alzheimer Abeta.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):777-83.
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2000: Goldstein L E; Leopold M C; Huang X; Atwood C S; Saunders A J; Hartshorn M; Lim J T; Faget K Y; Muffat J A; Scarpa R C; Chylack L T; Bowden E F; Tanzi R E; Bush A I
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Biochemistry 2000;39(24):7266-75.
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2000: Cuajungco M P; Goldstein L E; Nunomura A; Smith M A; Lim J T; Atwood C S; Huang X; Farrag Y W; Perry G; Bush A I
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.
The Journal of biological chemistry 2000;275(26):19439-42.
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2000: Huang X; Cuajungco M P; Atwood C S; Moir R D; Tanzi R E; Bush A I
Alzheimer's disease, beta-amyloid protein and zinc.
The Journal of nutrition 2000;130(5S Suppl):1488S-92S.
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2000: Bush A I
Metals and neuroscience.
Current opinion in chemical biology 2000;4(2):184-91.
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2000: Cuajungco M P; Fagét K Y; Huang X; Tanzi R E; Bush A I
Metal chelation as a potential therapy for Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;920():292-304.
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1999: Huang X; Cuajungco M P; Atwood C S; Hartshorn M A; Tyndall J D; Hanson G R; Stokes K C; Leopold M; Multhaup G; Goldstein L E; Scarpa R C; Saunders A J; Lim J; Moir R D; Glabe C; Bowden E F; Masters C L; Fairlie D P; Tanzi R E; Bush A I
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
The Journal of biological chemistry 1999;274(52):37111-6.
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1999: McLean C A; Cherny R A; Fraser F W; Fuller S J; Smith M J; Beyreuther K; Bush A I; Masters C L
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
Annals of neurology 1999;46(6):860-6.
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1999: White A R; Multhaup G; Maher F; Bellingham S; Camakaris J; Zheng H; Bush A I; Beyreuther K; Masters C L; Cappai R
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9170-9.
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1999: White A R; Reyes R; Mercer J F; Camakaris J; Zheng H; Bush A I; Multhaup G; Beyreuther K; Masters C L; Cappai R
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
Brain research 1999;842(2):439-44.
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1999: Cherny R A; Legg J T; McLean C A; Fairlie D P; Huang X; Atwood C S; Beyreuther K; Tanzi R E; Masters C L; Bush A I
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
The Journal of biological chemistry 1999;274(33):23223-8.
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1999: Moir R D; Atwood C S; Huang X; Tanzi R E; Bush A I
Mounting evidence for the involvement of zinc and copper in Alzheimer's disease.
European journal of clinical investigation 1999;29(7):569-70.
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1999: Huang X; Atwood C S; Hartshorn M A; Multhaup G; Goldstein L E; Scarpa R C; Cuajungco M P; Gray D N; Lim J; Moir R D; Tanzi R E; Bush A I
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Biochemistry 1999;38(24):7609-16.
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1999: Li Q X; Maynard C; Cappai R; McLean C A; Cherny R A; Lynch T; Culvenor J G; Trevaskis J; Tanner J E; Bailey K A; Czech C; Bush A I; Beyreuther K; Masters C L
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.
Journal of neurochemistry 1999;72(6):2479-87.
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1999: White A R; Bush A I; Beyreuther K; Masters C L; Cappai R
Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.
Journal of neurochemistry 1999;72(5):2092-8.
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1999: Moir R D; Atwood C S; Romano D M; Laurans M H; Huang X; Bush A I; Smith J D; Tanzi R E
Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.
Biochemistry 1999;38(14):4595-603.
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1999: Atwood C S; Huang X; Moir R D; Tanzi R E; Bush A I
Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease.
Metal ions in biological systems 1999;36():309-64.
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1998: Wolozin B; Maheshwari S; Jones C; Dukoff R; Wallace W; Racchi M; Nagula S; Shulman N R; Sunderland T; Bush A
Beta-amyloid augments platelet aggregation: reduced activity of familial angiopathy-associated mutants.
Molecular psychiatry 1998;3(6):500-7.
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1998: Bush A I; Tanzi R E
Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: the brain's delegate in the periphery?
Archives of neurology 1998;55(9):1179-80.
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1998: Atwood C S; Moir R D; Huang X; Scarpa R C; Bacarra N M; Romano D M; Hartshorn M A; Tanzi R E; Bush A I
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.
The Journal of biological chemistry 1998;273(21):12817-26.
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1998: Moir R D; Lynch T; Bush A I; Whyte S; Henry A; Portbury S; Multhaup G; Small D H; Tanzi R E; Beyreuther K; Masters C L
Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.
The Journal of biological chemistry 1998;273(9):5013-9.
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1998: Hock C; Golombowski S; Müller-Spahn F; Naser W; Beyreuther K; Mönning U; Schenk D; Vigo-Pelfrey C; Bush A M; Moir R; Tanzi R E; Growdon J H; Nitsch R M
Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity.
European neurology 1998;39(2):111-8.
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1997: Huang X; Atwood C S; Moir R D; Hartshorn M A; Vonsattel J P; Tanzi R E; Bush A I
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.
The Journal of biological chemistry 1997;272(42):26464-70.
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1997: Aschner M; Cherian M G; Klaassen C D; Palmiter R D; Erickson J C; Bush A I
Metallothioneins in brain--the role in physiology and pathology.
Toxicology and applied pharmacology 1997;142(2):229-42.
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1995: Kounnas M Z; Moir R D; Rebeck G W; Bush A I; Argraves W S; Tanzi R E; Hyman B T; Strickland D K
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
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1994: Multhaup G; Bush A I; Pollwein P; Masters C L
Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).
FEBS letters 1994;355(2):151-4.
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1994: Bush A I; Pettingell W H; de Paradis M; Tanzi R E; Wasco W
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.
The Journal of biological chemistry 1994;269(43):26618-21.
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1994: Bush A I; Pettingell W H; Multhaup G; d Paradis M; Vonsattel J P; Gusella J F; Beyreuther K; Masters C L; Tanzi R E
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Science (New York, N.Y.) 1994;265(5177):1464-7.
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1994: Li Q X; Berndt M C; Bush A I; Rumble B; Mackenzie I; Friedhuber A; Beyreuther K; Masters C L
Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet.
Blood 1994;84(1):133-42.
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1994: Bush A I; Pettingell W H; Paradis M D; Tanzi R E
Modulation of A beta adhesiveness and secretase site cleavage by zinc.
The Journal of biological chemistry 1994;269(16):12152-8.
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1994: Tanzi R E; Bush A I; Wasco W
Genetic studies of Alzheimer's disease: lessons learned and future imperatives.
Neurobiology of aging 1994;15 Suppl 2():S145-8.
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1993: Bush A I; Beyreuther K; Masters C L
The beta A4 amyloid protein precursor in human circulation.
Annals of the New York Academy of Sciences 1993;695():175-82.
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1993: Bush A I; Multhaup G; Moir R D; Williamson T G; Small D H; Rumble B; Pollwein P; Beyreuther K; Masters C L
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
The Journal of biological chemistry 1993;268(22):16109-12.
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1993: Tanzi R; Gaston S; Bush A; Romano D; Pettingell W; Peppercorn J; Paradis M; Gurubhagavatula S; Jenkins B; Wasco W
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.
Genetica 1993;91(1-3):255-63.
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1992: Moir R D; Martins R N; Bush A I; Small D H; Milward E A; Rumble B A; Multhaup G; Beyreuther K; Masters C L
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.
Journal of neurochemistry 1992;59(4):1490-8.
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1992: Bush A I; Whyte S; Thomas L D; Williamson T G; Van Tiggelen C J; Currie J; Small D H; Moir R D; Li Q X; Rumble B
An abnormality of plasma amyloid protein precursor in Alzheimer's disease.
Annals of neurology 1992;32(1):57-65.
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1992: Bush A I; Beyreuther K; Masters C L
Beta A4 amyloid protein and its precursor in Alzheimer's disease.
Pharmacology & therapeutics 1992;56(1):97-117.
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1991: Small D H; Moir R D; Fuller S J; Michaelson S; Bush A I; Li Q X; Milward E; Hilbich C; Weidemann A; Beyreuther K
A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease.
Biochemistry 1991;30(44):10795-9.
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1991: Beyreuther K; Bush A I; Dyrks T; Hilbich C; König G; Mönning U; Multhaup G; Prior R; Rumble B; Schubert W
Mechanisms of amyloid deposition in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():129-39.
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1990: Bush A I; Martins R N; Rumble B; Moir R; Fuller S; Milward E; Currie J; Ames D; Weidemann A; Fischer P
The amyloid precursor protein of Alzheimer's disease is released by human platelets.
The Journal of biological chemistry 1990;265(26):15977-83.
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1990: Bush A I; Huang W; Copolov D L; Lim A T
Hypothalamic atrial natriuretic peptide secretion plasticity: differential modulation of alpha and beta adrenoceptors.
Neuroendocrinology 1990;52(1):65-9.
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