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Greg Plowman

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Chemicals & Drugs

Physiology

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Shaija Samuel; Anil K Sood; Ling Xia; Anil Bagri; Debashish Bose; Nikolaos A Dallas; Fan Fan; Puja Gaur; Michael J Gray; Gabriel Lopez-Berestein; Greg Plowman; Cristian Rodriguez-Aguayo; Lee M Ellis
Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines.
Anil Bagri; Leanne Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A Damico; Hong Xiang; Maike Schmidt; Germaine Fuh; Beth Hollister; Oliver Rosen; Greg Plowman
Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy.
Anil Bagri; Hosein Kouros-Mehr; Kevin G Leong; Greg Plowman
Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale.

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All Publications

2011: Shaija Samuel; Anil K Sood; Ling Xia; Anil Bagri; Debashish Bose; Nikolaos A Dallas; Fan Fan; Puja Gaur; Michael J Gray; Gabriel Lopez-Berestein; Greg Plowman; Cristian Rodriguez-Aguayo; Lee M Ellis
Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines.
PloS one 2011;6(10):e23208.
2010: Anil Bagri; Leanne Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A Damico; Hong Xiang; Maike Schmidt; Germaine Fuh; Beth Hollister; Oliver Rosen; Greg Plowman
Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(15):3887-900.
2010: Anil Bagri; Hosein Kouros-Mehr; Kevin G Leong; Greg Plowman
Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale.
Trends in molecular medicine 2010;16(3):122-32.
2008: Maresa Caunt; Judy Mak; Wei-Ching Liang; Scott Stawicki; Qi Pan; Raymond K Tong; Joe Kowalski; Calvin Ho; Hani Bou Reslan; Jed Ross; Leanne Berry; Ian Kasman; Constance Zlot; Zhiyong Cheng; Jennifer Le Couter; Ellen H Filvaroff; Greg Plowman; Franklin Peale; Dorothy French; Richard Carano; Alexander W Koch; Yan Wu; Ryan J Watts; Marc Tessier-Lavigne; Anil Bagri
Blocking neuropilin-2 function inhibits tumor cell metastasis.
Cancer cell 2008;13(4):331-42.
2007: Minhong Yan; Greg Plowman
Delta-like 4/Notch signaling and its therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(24):7243-6.
2007: Qi Pan; Yvan Chanthery; Wei-Ching Liang; Scott Stawicki; Judy Mak; Nisha Rathore; Raymond K Tong; Joe Kowalski; Sharon Fong Yee; Glenn Pacheco; Sarajane Ross; Zhiyong Cheng; Jennifer Le Couter; Greg Plowman; Franklin Peale; Alexander W Koch; Yan Wu; Anil Bagri; Marc Tessier-Lavigne; Ryan J Watts
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.
Cancer cell 2007;11(1):53-67.
2006: John Ridgway; Gu Zhang; Yan Wu; Scott Stawicki; Wei-Ching Liang; Yvan Chanthery; Joe Kowalski; Ryan J Watts; Christopher Callahan; Ian Kasman; Mallika Singh; May Chien; Christine Tan; Jo-Anne S Hongo; Frederic J de Sauvage; Greg Plowman; Minhong Yan
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
Nature 2006;444(7122):1083-7.
2005: Kyle A Edgar; Marcia Belvin; Annette L Parks; Kellie Whittaker; Matt B Mahoney; Monique Nicoll; Christopher C Park; Christopher G Winter; Feng Chen; Kim Lickteig; Ferhad Ahmad; Hanife Esengil; Matthew V Lorenzi; Amanda Norton; Brent A Rupnow; Laleh Shayesteh; Mariano Tabios; Lynn M Young; Pamela M Carroll; Casey Kopczynski; Greg Plowman; Lori S Friedman; Helen L Francis-Lang
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.
Genetics 2005;170(1):161-71.
2005: Mark R Lackner; Rachel M Kindt; Pamela M Carroll; Katherine Brown; Michael Cancilla; Changyou Chen; Heshani de Silva; Yvonne Franke; Bo Guan; Tim Heuer; Tak Hung; Kevin Keegan; Jae Moon Lee; swam manne; Carol O'Brien; Dianne Parry; Juan J Perez-Villar; Rajashekar K Reddy; Hong Xiao; Hangjun Zhan; Mark Cockett; Greg Plowman; Kevin FitzGerald; Michael Costa; Petra Ross-Macdonald
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Cancer cell 2005;7(4):325-36.
2004: Jonathan Margolis; Greg Plowman
Overcoming the gridlock in discovery research.
Nature biotechnology 2004;22(5):522-4.
2004: Annette L Parks; Kevin R Cook; Marcia Belvin; Nicholas A Dompe; Robert Fawcett; Kari Huppert; Lory R Tan; Christopher G Winter; Kevin P Bogart; Jennifer E Deal; Megan E Deal-Herr; Deanna Grant; Marie Marcinko; Wesley Y Miyazaki; Stephanie Robertson; Kenneth J Shaw; Mariano Tabios; Valentina Vysotskaia; Lora Zhao; Rachel S Andrade; Kyle A Edgar; Elizabeth Howie; Keith Killpack; Brett Milash; Amanda Norton; Doua Thao; Kellie Whittaker; Millicent A Winner; Lori Friedman; Jonathan Margolis; Matthew A Singer; Casey Kopczynski; Daniel Curtis; Thomas C Kaufman; Greg Plowman; Geoffrey Duyk; Helen L Francis-Lang
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.
Nature genetics 2004;36(3):288-92.
2002: Gerard Manning; Greg Plowman; Tony Hunter; Sucha Sudarsanam
Evolution of protein kinase signaling from yeast to man.
Trends in biochemical sciences 2002;27(10):514-20.
2000: J Bingham; Greg Plowman; Sucha Sudarsanam
Informatics issues in large-scale sequence analysis: elucidating the protein kinases of C. elegans.
Journal of cellular biochemistry 2000;80(2):181-6.
1999: Greg Plowman; Sucha Sudarsanam; J Bingham; David B Whyte; Tony Hunter
The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13603-10.
1999: YJ Ma; DF Hill; K E Creswick; Maria E Costa; Anda Cornea; M N Lioubin; Greg Plowman; Sergio R Ojeda
Neuregulins signaling via a glial erbB-2-erbB-4 receptor complex contribute to the neuroendocrine control of mammalian sexual development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9913-27.
1999: J R Bischoff; Greg Plowman
The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.
Trends in cell biology 1999;9(11):454-9.
1999: J Andreev; JP Simon; David D Sabatini; J Kam; Greg Plowman; P A Randazzo; Joseph Schlessinger
Identification of a new Pyk2 target protein with Arf-GAP activity.
Molecular and cellular biology 1999;19(3):2338-50.
1999: S Lev; J Hernandez; R Martinez; A Chen; Greg Plowman; Joseph Schlessinger
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.
Molecular and cellular biology 1999;19(3):2278-88.
1998: S A Courtneidge; Greg Plowman
The discovery and validation of new drug targets in cancer.
Current opinion in biotechnology 1998;9(6):632-6.
1998: CL Brown; Katherine S Meise; Greg Plowman; Robert J Coffey; Peter J Dempsey
Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form.
The Journal of biological chemistry 1998;273(27):17258-68.
1998: J R Bischoff; L Anderson; Y Zhu; K Mossie; L Ng; B Souza; Brian Schryver; P Flanagan; Felix Clairvoyant; C Ginther; C S Chan; M Novotny; Dennis J Slamon; Greg Plowman
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers.
The EMBO journal 1998;17(11):3052-65.
1998: DJ Riese; T Komurasaki; Greg Plowman; David F Stern
Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.
The Journal of biological chemistry 1998;273(18):11288-94.
1997: Paul W Cook; Michael Piepkorn; C H Clegg; Greg Plowman; J M DeMay; J R Brown; Mark Pittelkow
Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.
The Journal of clinical investigation 1997;100(9):2286-94.
1997: Klaus Elenius; Gabriel Corfas; S Paul; C J Choi; Carlos Rio; Greg Plowman; Michael Klagsbrun
A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.
The Journal of biological chemistry 1997;272(42):26761-8.
1997: Sanjoy K Das; N Das; J Wang; Hyunjung Lim; Brian Schryver; Greg Plowman; Sudhansu K Dey
Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation.
Developmental biology 1997;190(2):178-90.
1997: Elior Peles; K Joho; Greg Plowman; J Schlessinger
Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions.
Cell 1997;88(6):745-6.
1997: Elior Peles; M Nativ; Marc J Lustig; Martin Grumet; J Schilling; R Martinez; Greg Plowman; Joseph Schlessinger
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.
The EMBO journal 1997;16(5):978-88.
1997: B Smolich; M Vo; S Buckley; Greg Plowman; J Papkoff
Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains.
Journal of biochemistry 1997;121(2):382-8.
1997: Tony Hunter; Greg Plowman
The protein kinases of budding yeast: six score and more.
Trends in biochemical sciences 1997;22(1):18-22.
1996: DJ Riese; E D Kim; Klaus Elenius; S Buckley; Michael Klagsbrun; Greg Plowman; David F Stern
The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
The Journal of biological chemistry 1996;271(33):20047-52.
1996: Lucia Schuger; G R Johnson; Kevin Gilbride; Greg Plowman; R Mandel
Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation.
Development (Cambridge, England) 1996;122(6):1759-67.
1996: DJ Riese; Y Bermingham; T M van Raaij; S Buckley; Greg Plowman; David F Stern
Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.
Oncogene 1996;12(2):345-53.
1995: K Mossie; Bahija Jallal; F Alves; Irmi Sures; Greg Plowman; A Ullrich
Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.
Oncogene 1995;11(10):2179-84.
1995: DJ Riese; T M van Raaij; Greg Plowman; glenn andrews; David F Stern
The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.
Molecular and cellular biology 1995;15(10):5770-6.
1995: Nicola Normanno; N Kim; D Wen; K Smith; A L Harris; Greg Plowman; Giulia Colletta; Fortunato Ciardiello; D S Salomon
Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas.
Breast cancer research and treatment 1995;35(3):293-7.
1995: S Lev; H Moreno; R Martinez; P Canoll; Elior Peles; J M Musacchio; Greg Plowman; Bernardo Rudy; Joseph Schlessinger
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
Nature 1995;376(6543):737-45.
1995: Elior Peles; M Nativ; P L Campbell; Takeshi Sakurai; R Martinez; S Lev; D O Clary; J Schilling; Gilad Barnea; Greg Plowman; Martin Grumet; Joseph Schlessinger
The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.
Cell 1995;82(2):251-60.
1995: N J Kenney; Ruo-Pan Huang; G R Johnson; J X Wu; D Okamura; W Matheny; E Kordon; W J Gullick; Greg Plowman; G H Smith
Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland.
Molecular reproduction and development 1995;41(3):277-86.
1995: B G Pathak; DJ Gilbert; C A Harrison; N C Luetteke; X Chen; M Klagsbrun; Greg Plowman; Neal G Copeland; Nancy A Jenkins; D C Lee
Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl).
Genomics 1995;28(1):116-8.
1995: Sanjoy K Das; I Chakraborty; Bibhash C Paria; X N Wang; Greg Plowman; Sudhansu K Dey
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus.
Molecular endocrinology (Baltimore, Md.) 1995;9(6):691-705.
1995: D A Vardy; Csaba Kari; GERALD LAZARUS; Pamela J Jensen; A Zilberstein; Greg Plowman; Ulrich Rodeck
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1.
Journal of cellular physiology 1995;163(2):257-65.
1995: Clay B Siegall; Sarah S Bacus; B D Cohen; Greg Plowman; Bruce J Mixan; Dana F Chace; D M Chin; A Goetze; J M Green; I Hellström
HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein.
The Journal of biological chemistry 1995;270(13):7625-30.
1995: Craig D Woodworth; E McMullin; M Iglesias; Greg Plowman
Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2840-4.
1995: KL Bennett; D G Jackson; Jan C Simon; E Tanczos; Robert Peach; B Modrell; Ivan Stamenkovic; Greg Plowman; Alejandro Aruffo
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.
The Journal of cell biology 1995;128(4):687-98.
1994: Sarah S Bacus; C R Zelnick; Greg Plowman; Yosef Yarden
Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.
American journal of clinical pathology 1994;102(4 Suppl 1):S13-24.
1994: J Skonier; K Bennett; V Rothwell; S Kosowski; Greg Plowman; P Wallace; S Edelhoff; C Disteche; M Neubauer; H Marquardt
beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice.
DNA and cell biology 1994;13(6):571-84.
1994: Michael Piepkorn; C Lo; Greg Plowman
Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans.
Journal of cellular physiology 1994;159(1):114-20.
1994: Nicola Normanno; M P Selvam; C F Qi; T Saeki; G Johnson; N Kim; Fortunato Ciardiello; M Shoyab; Greg Plowman; R Brandt
Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2790-4.
1994: B A Thorne; Greg Plowman
The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion.
Molecular and cellular biology 1994;14(3):1635-46.
1993: Greg Plowman; J M Green; J M Culouscou; G W Carlton; V M Rothwell; S Buckley
Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.
Nature 1993;366(6454):473-5.
1993: J M Culouscou; Greg Plowman; G W Carlton; J M Green; M Shoyab
Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.
The Journal of biological chemistry 1993;268(25):18407-10.
1993: S LeJeune; Russell Leek; E Horak; Greg Plowman; M Greenall; Adrian L Harris
Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer.
Cancer research 1993;53(15):3597-602.
1993: Greg Plowman; J M Culouscou; Gena S Whitney; J M Green; G W Carlton; L Foy; M G Neubauer; M Shoyab
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1746-50.
1992: D N Poller; Ian Spendlove; C Baker; R Church; Ian O Ellis; Greg Plowman; R J Mayer
Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas.
The Journal of pathology 1992;168(3):275-80.
1992: Greg Plowman; J M Green; M G Neubauer; S D Buckley; V L McDonald; G J Todaro; M Shoyab
The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
The Journal of biological chemistry 1992;267(18):13073-8.
1991: M Shoyab; V L McDonald; K Dick; B Modrell; N Malik; Greg Plowman
Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7.
Biochemical and biophysical research communications 1991;179(1):572-8.
1990: Greg Plowman; Gena S Whitney; M G Neubauer; J M Green; V L McDonald; G J Todaro; M Shoyab
Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):4905-9.
1990: Greg Plowman; J M Green; V L McDonald; M G Neubauer; C M Disteche; G J Todaro; M Shoyab
The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
Molecular and cellular biology 1990;10(5):1969-81.
1989: M Shoyab; Greg Plowman; V L McDonald; J G Bradley; G J Todaro
Structure and function of human amphiregulin: a member of the epidermal growth factor family.
Science (New York, N.Y.) 1989;243(4894 Pt 1):1074-6.