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Karl-Norbert Klotz

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Saleta Vazquez-Rodriguez; Fernanda Borges; Sonja Kachler; Maria João Matos; Lourdes Santana; Eugenio Uriarte; Karl-Norbert Klotz
Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists.
Maria João Matos; Lourdes Santana; Fernanda Borges; Alexandra Gaspar; Sonja Kachler; Karl-Norbert Klotz; Eugenio Uriarte
Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives.
Stephanie Federico; Karl-Norbert Klotz; Stefano Moro; Silvia Paoletta; Giorgia Pastorin; Davide Sabbadin; Barbara Cacciari; Antonella Ciancetta; Giampiero Spalluto
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.

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2013: Saleta Vazquez-Rodriguez; Fernanda Borges; Sonja Kachler; Maria João Matos; Lourdes Santana; Eugenio Uriarte; Karl-Norbert Klotz
Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists.
The Journal of pharmacy and pharmacology 2013;65(5):697-703.
2013: Maria João Matos; Lourdes Santana; Fernanda Borges; Alexandra Gaspar; Sonja Kachler; Karl-Norbert Klotz; Eugenio Uriarte
Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives.
The Journal of pharmacy and pharmacology 2013;65(1):30-4.
2012: Stephanie Federico; Karl-Norbert Klotz; Stefano Moro; Silvia Paoletta; Giorgia Pastorin; Davide Sabbadin; Barbara Cacciari; Antonella Ciancetta; Giampiero Spalluto
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(22):9654-68.
2012: Alexandra Gaspar; Sonja Kachler; Karl-Norbert Klotz; Stefano Moro; Silvia Paoletta; Joana Reis; Eugenio Uriarte; Fernanda Borges
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold.
Biochemical pharmacology 2012;84(1):21-9.
2012: Kyle Jensen; L'Aurelle A Johnson; Sonja Kachler; Mark N Kirstein; Pamala A Jacobson; Jatinder Lamba; Karl-Norbert Klotz
Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 2012;385(5):519-25.
2011: Siew Lee Cheong; Anton V Dolzhenko; Anna V Dolzhenko; Stephanie Federico; Sonja Kachler; Karl-Norbert Klotz; Evelyn Pei Rong Lee; Stefano Moro; Silvia Paoletta; Giampiero Spalluto; Giorgia Pastorin
Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?
Bioorganic & medicinal chemistry 2011;19(20):6120-34.
2011: Sebastian F M Häusler; Stefan Heuer; Arnd Hönig; Evi Horn; Markus Junker; Doris Kloor; Karl-Norbert Klotz; Hermann Kneitz; Mathias Krockenberger; Itsaso Montalbán del Barrio; Monika Ossadnik; Ahmed Adel Seida; Jenny Strohschein; P Anoop Chandran; Johannes Dietl; Jörg Engel; Birgitt Fischer; Jörg Wischhusen
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.
Cancer immunology, immunotherapy : CII 2011;60(10):1405-18.
2011: Stephanie Federico; Zhan-Guo Gao; Kenneth Alan Jacobson; Karl-Norbert Klotz; Stefano Moro; Silvia Paoletta; Giorgia Pastorin; Jeffrey Siegel; Barbara Cacciari; Siew Lee Cheong; Stefano Stragliotto; Giampiero Spalluto
Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.
Journal of medicinal chemistry 2011;54(3):877-89.
2010: Maria Letizia Trincavelli; Serena Cuboni; Mario Catena Dell'osso; Roberto Maggio; Karl-Norbert Klotz; Francesca Novi; Anna Panighini; Simona Daniele; Claudia Martini
Receptor crosstalk: haloperidol treatment enhances A(2A) adenosine receptor functioning in a transfected cell model.
Purinergic signalling 2010;6(4):373-81.
2010: Siew Lee Cheong; Anna Dolzhenko; Sonja Kachler; Silvia Paoletta; Stephanie Federico; Barbara Cacciari; Anton Dolzhenko; Karl-Norbert Klotz; Stefano Moro; Giampiero Spalluto; Giorgia Pastorin
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
Journal of medicinal chemistry 2010;53(8):3361-75.
2010: Giorgia Pastorin; Stephanie Federico; Silvia Paoletta; Marta Corradino; Francesca Cateni; Barbara Cacciari; Karl-Norbert Klotz; Zhan-Guo Gao; Kenneth Alan Jacobson; Giampiero Spalluto; Stefano Moro
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.
Bioorganic & medicinal chemistry 2010;18(7):2524-36.
2009: Rosaria Volpini; Michela Buccioni; Diego Dal Ben; Catia Lambertucci; Carmen Lammi; Gabriella Marucci; Anna T Ramadori; Karl-Norbert Klotz; Gloria Cristalli
Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.
Journal of medicinal chemistry 2009;52(23):7897-900.
2009: Lisa Michielan; Federico Stephanie; Lothar Terfloth; Dimitar Hristozov; Barbara Cacciari; Karl-Norbert Klotz; Giampiero Spalluto; Johann Gasteiger; Stefano Moro
Exploring potency and selectivity receptor antagonist profiles using a multilabel classification approach: the human adenosine receptors as a key study.
Journal of chemical information and modeling 2009;49(12):2820-36.
2009: Lisa Michielan; Chiara Bolcato; Stephanie Federico; Barbara Cacciari; Magdalena Bacilieri; Karl-Norbert Klotz; Sonja Kachler; Giorgia Pastorin; Riccardo Cardin; Alessandro Sperduti; Giampiero Spalluto; Stefano Moro
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.
Bioorganic & medicinal chemistry 2009;17(14):5259-74.
2009: Rosaria Volpini; Diego Dal Ben; Catia Lambertucci; Gabriella Marucci; Ram Chandra MISHRA; Anna Teresa Ramadori; Karl-Norbert Klotz; Maria Letizia Trincavelli; Claudia Martini; Gloria Cristalli
Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
ChemMedChem 2009;4(6):1010-9.
2009: Palmarisa Franchetti; Loredana Cappellacci; Patrizia Vita; Riccardo Petrelli; Antonio Lavecchia; Sonja Kachler; Karl-Norbert Klotz; Ida Marabese; Livio Luongo; Sabatino Maione; Mario Grifantini
N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.
Journal of medicinal chemistry 2009;52(8):2393-406.
2009: Catia Lambertucci; Ippolito Antonini; Michela Buccioni; Diego Dal Ben; Dhuldeo D Kachare; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
Bioorganic & medicinal chemistry 2009;17(7):2812-22.
2009: Sandra Dorsch; Karl-Norbert Klotz; Stefan Engelhardt; Martin J Lohse; Moritz Bünemann
Analysis of receptor oligomerization by FRAP microscopy.
Nature methods 2009;6(3):225-30.
2009: P Fishman; S Bar-Yehuda; M Synowitz; Jonathan D Powell; Karl-Norbert Klotz; S Gessi; P A Borea
Adenosine receptors and cancer.
Handbook of experimental pharmacology 2009;(193):399-441.
2008: Chiara Bolcato; Claudia Cusan; Giorgia Pastorin; Giampiero Spalluto; Barbara Cacciari; Karl-Norbert Klotz; Erika Morizzo; Stefano Moro
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes.
Purinergic signalling 2008;4(1):39-46.
2008: Lisa Michielan; Magdalena Bacilieri; Andrea Schiesaro; Chiara Bolcato; Giorgia Pastorin; Giampiero Spalluto; Barbara Cacciari; Karl-Norbert Klotz; Chosei Kaseda; Stefano Moro
Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor.
Journal of chemical information and modeling 2008;48(2):350-63.
2008: Loredana Cappellacci; Palmarisa Franchetti; Patrizia Vita; Riccardo Petrelli; Antonio Lavecchia; Barbara Costa; Francesca Spinetti; Claudia Martini; Karl-Norbert Klotz; Mario Grifantini
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.
Bioorganic & medicinal chemistry 2008;16(1):336-53.
2007: Catia Lambertucci; Gloria Cristalli; Diego Dal Ben; Dhuldeo D Kachare; Chiara Bolcato; Karl-Norbert Klotz; Giampiero Spalluto; Rosaria Volpini
New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile.
Purinergic signalling 2007;3(4):339-46.
2007: Barbara Cacciari; Chiara Bolcato; Giampiero Spalluto; Karl-Norbert Klotz; Magdalena Bacilieri; Francesca Deflorian; Stefano Moro
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile.
Purinergic signalling 2007;3(3):183-93.
2007: Clelia Dallanoce; Fabio Frigerio; Marco De Amici; Sandra Dorsch; Karl-Norbert Klotz; Carlo De Micheli
Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes.
Bioorganic & medicinal chemistry 2007;15(7):2533-43.
2007: Rosaria Volpini; Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.
Journal of medicinal chemistry 2007;50(6):1222-30.
2007: Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands.
Purinergic signalling 2007;3(1-2):181.
2007: Karl-Norbert Klotz; Nico Falgner; Sonja Kachler; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
[3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor.
European journal of pharmacology 2007;556(1-3):14-8.
2007: Catia Lambertucci; Sauro Vittori; Ram Chandra MISHRA; Diego Dal Ben; Karl-Norbert Klotz; Rosaria Volpini; Gloria Cristalli
Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1443-6.
2006: Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini; Gloria Cristalli; Karl-Norbert Klotz
Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A₃ adenosine receptor ligands.
Purinergic signalling 2006;2(4):589-94.
2006: Markus Lange; Thorsten M Smul; Christoph A Blomeyer; Andreas Redel; Karl-Norbert Klotz; Norbert Roewer; Franz Kehl
Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo.
Anesthesiology 2006;105(3):503-10.
2006: Stefanie Weyler; Friederike Fülle; Martina Diekmann; Britta Schumacher; Sonja Hinz; Karl-Norbert Klotz; Christa E Müller
Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones.
ChemMedChem 2006;1(8):891-902.
2006: Stefano Moro; Magdalena Bacilieri; Barbara Cacciari; Chiara Bolcato; Claudia Cusan; Giorgia Pastorin; Karl-Norbert Klotz; Giampiero Spalluto
The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist.
Bioorganic & medicinal chemistry 2006;14(14):4923-32.
2006: Luo Yan; Daniela C G Bertarelli; Alaa M Hayallah; Heiko Meyer; Karl-Norbert Klotz; Christa E Müller
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
Journal of medicinal chemistry 2006;49(14):4384-91.
2006: Clelia Dallanoce; Giuseppe Meroni; Marco De Amici; Carsten Hoffmann; Karl-Norbert Klotz; Carlo De Micheli
Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes.
Bioorganic & medicinal chemistry 2006;14(13):4393-401.
2006: Björn Behr; Carsten Hoffmann; Gianluca Ottolina; Karl-Norbert Klotz
Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
The Journal of biological chemistry 2006;281(26):18120-5.
2006: Michael P Schön; Margarete Schön; Karl-Norbert Klotz
The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion.
The Journal of investigative dermatology 2006;126(6):1338-47.
2005: Ettore Novellino; Barbara Cosimelli; Marina Ehlardo; Giovanni Greco; Manuela Iadanza; Antonio Lavecchia; Maria Grazia Rimoli; Annalisa Sala; Antonio Da Settimo; Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Karl-Norbert Klotz; Daniela Tuscano; Maria Letizia Trincavelli; Claudia Martini
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
Journal of medicinal chemistry 2005;48(26):8253-60.
2005: Katia Varani; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Annalisa Benini; Karl-Norbert Klotz; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stephen Mac Lennan; Edward Leung; Pier Andrea Borea
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.
Biochemical pharmacology 2005;70(11):1601-12.
2005: Giorgia Pastorin; Chiara Bolcato; Barbara Cacciari; Sonja Kachler; Karl-Norbert Klotz; Christian Montopoli; Stefano Moro; Giampiero Spalluto
Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists.
Farmaco (Società chimica italiana : 1989) 2005;60(8):643-51.
2005: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sauro Vittori; Claudia Martini; M Letizia Trincavelli; Karl-Norbert Klotz; Gloria Cristalli
2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors.
Purinergic signalling 2005;1(2):173-81.
2005: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Cecilia Pancaldi; Youri Szabadkai; Rosario Rizzuto; Karl-Norbert Klotz; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Molecular pharmacology 2005;67(6):2137-47.
2005: Mojtaba Panjehpour; Marian Castro; Karl-Norbert Klotz
Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal.
British journal of pharmacology 2005;145(2):211-8.
2005: Giorgia Pastorin; Chiara Bolcato; Barbara Cacciari; Sonja Kachler; Karl-Norbert Klotz; Christian Montopoli; Stefano Moro; Giampiero Spalluto
Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists.
Farmaco (Società chimica italiana : 1989) 2005;60(4):299-306.
2005: Loredana Cappellacci; Palmarisa Franchetti; Michela Pasqualini; Riccardo Petrelli; Patrizia Vita; Antonio Lavecchia; Ettore Novellino; Barbara Costa; Claudia Martini; Karl-Norbert Klotz; Mario Grifantini
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Journal of medicinal chemistry 2005;48(5):1550-62.
2005: Sauro Vittori; Rosaria Volpini; Catia Lambertucci; Sara Taffi; Karl-Norbert Klotz; Gloria Cristalli
2-substituted 5'-N-methylcarboxamidoadenosine (MECA) derivatives as A3 adenosine receptor ligands.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):935-8.
2004: Prakash Jagtap; Zhiyu Chen; Csaba Szabó; Karl-Norbert Klotz
2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.
Bioorganic & medicinal chemistry letters 2004;14(6):1495-8.
2004: C Hoffmann; M R Leitz; Silke Oberdorf-Maass; Martin J Lohse; Karl-Norbert Klotz
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(2):151-9.
2004: Sauro Vittori; Stefano Costanzi; Catia Lambertucci; F R Portino; Sara Taffi; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):471-81.
2003: Karl-Norbert Klotz; Sonja Kachler; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(6):629-34.
2003: Jutta Hessling; Martin J Lohse; Karl-Norbert Klotz
Peptide G protein agonists from a phage display library.
Biochemical pharmacology 2003;65(6):961-7.
2003: Rosaria Volpini; Stefano Costanzi; Sauro Vittori; Gloria Cristalli; Karl-Norbert Klotz
Medicinal chemistry and pharmacology of A2B adenosine receptors.
Current topics in medicinal chemistry 2003;3(4):427-43.
2002: Stefania Merighi; Prisco Mirandola; Daniela Milani; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.
The Journal of investigative dermatology 2002;119(4):923-33.
2002: Maria Letizia Trincavelli; Daniela Tuscano; Matteo Marroni; Karl-Norbert Klotz; Antonio Lucacchini; Claudia Martini
Involvement of mitogen protein kinase cascade in agonist-mediated human A(3) adenosine receptor regulation.
Biochimica et biophysica acta 2002;1591(1-3):55-62.
2002: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sara Taffi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.
Journal of medicinal chemistry 2002;45(15):3271-9.
2002: Martin Englert; Ursula Quitterer; Karl-Norbert Klotz
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Biochemical pharmacology 2002;64(1):61-5.
2002: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; Giampiero Spalluto; Giorgia Pastorin; Tatiana Da Ros; Karl-Norbert Klotz; Katia Varani; Stefania Gessi; Pier Andrea Borea
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(4):770-80.
2002: Stefania Merighi; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 2002;63(2):157-61.
2001: Marco Macchia; teresina laragione; Simone Bertini; Valeria Di Bussolo; L Gattuso; Marco Gesi; Mahmoud Hamdan; Karl-Norbert Klotz; T Laragione; Antonio Lucacchini; Filippo Minutolo; Susanna Nencetti; Chiara Papi; Daniela Tuscano; Claudia Martini
7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.
Bioorganic & medicinal chemistry letters 2001;11(23):3023-6.
2001: Bertil B. Fredholm; Adriaan P IJzerman; Kenneth Alan Jacobson; Karl-Norbert Klotz; J Linden
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
Pharmacological reviews 2001;53(4):527-52.
2001: S Graham; P Combes; M Crumiere; Karl-Norbert Klotz; John M Dickenson
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells.
European journal of pharmacology 2001;420(1):19-26.
2000: P G Baraldi; Barbara Cacciari; R Romagnoli; Giampiero Spalluto; Stefano Moro; Karl-Norbert Klotz; E Leung; K Varani; Stefania Gessi; Stefania Merighi; P A Borea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.
Journal of medicinal chemistry 2000;43(25):4768-80.
2000: Sonja Hess; Christa E Müller; W Frobenius; Ulrike Reith; Karl-Norbert Klotz; Kurt Eger
7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(24):4636-46.
2000: Karl-Norbert Klotz
Adenosine receptors and their ligands.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):382-91.
2000: Peter Illes; Karl-Norbert Klotz; M J Lohse
Signaling by extracellular nucleotides and nucleosides.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):295-8.
2000: Maria Letizia Trincavelli; Daniela Tuscano; Paolo Cecchetti; Alessandra Falleni; Luca Benzi; Karl-Norbert Klotz; Vittorio Gremigni; Flaminio Nicola Cattabeni; Antonio Lucacchini; Claudia Martini
Agonist-induced internalization and recycling of the human A(3) adenosine receptors: role in receptor desensitization and resensitization.
Journal of neurochemistry 2000;75(4):1493-501.
2000: Katia Varani; Stefania Merighi; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Pier Andrea Borea
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 2000;57(5):968-75.
2000: Roberta Brambilla; Flaminio Nicola Cattabeni; Stefania Ceruti; D Barbieri; Claudio Franceschi; Y C Kim; Kenneth Alan Jacobson; Karl-Norbert Klotz; M J Lohse; Maria P Abbracchio
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(3):225-34.
2000: R Sauer; J Maurinsh; Ulrike Reith; Friederike Fülle; Karl-Norbert Klotz; Christa E Müller
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(3):440-8.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Karl-Norbert Klotz; E Leung; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4473-8.
1999: Rosaria Volpini; E Camaioni; Stefano Costanzi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes.
Nucleosides & nucleotides 1999;18(11-12):2511-20.
1999: Karl-Norbert Klotz; E Camaioni; Rosaria Volpini; Sonja Kachler; Sauro Vittori; Gloria Cristalli
2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(2):103-8.
1999: Sauro Vittori; E Camaioni; Stefano Costanzi; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
Synthesis and receptor affinity of polysubstituted adenosines.
Nucleosides & nucleotides 1999;18(4-5):739-40.
1998: Christa E Müller; Jesús Sandoval-Ramírez; Ulrike Schobert; U Geis; W Frobenius; Karl-Norbert Klotz
8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.
Bioorganic & medicinal chemistry 1998;6(6):707-19.
1998: E Camaioni; Stefano Costanzi; Sauro Vittori; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
New substituted 9-alkylpurines as adenosine receptor ligands.
Bioorganic & medicinal chemistry 1998;6(5):523-33.
1998: Paola Conti; Clelia Dallanoce; Marco De Amici; Carlo De Micheli; Karl-Norbert Klotz
Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.
Bioorganic & medicinal chemistry 1998;6(4):401-8.
1998: Karl-Norbert Klotz; J Hessling; J Hegler; C Owman; Björn Kull; Bertil B. Fredholm; Martin J Lohse
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(1):1-9.
1997: Knut Biber; Karl-Norbert Klotz; M Berger; PJ Gebicke-Härter; Dietrich van Calker
Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):4956-64.
1995: Karl-Norbert Klotz
Defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(7):567.
1994: Karl-Norbert Klotz; Algirdas J Jesaitis
The interaction of N-formyl peptide chemoattractant receptors with the membrane skeleton is energy-dependent.
Cellular signalling 1994;6(8):943-7.
1994: Karl-Norbert Klotz; Algirdas J Jesaitis
Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization.
Biochemical pharmacology 1994;48(6):1297-300.
1994: Karl-Norbert Klotz; Algirdas J Jesaitis
Neutrophil chemoattractant receptors and the membrane skeleton.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(3):193-8.
1994: Karl-Norbert Klotz; K L Krotec; Jeannie M Gripentrog; Algirdas J Jesaitis
Regulatory interaction of N-formyl peptide chemoattractant receptors with the membrane skeleton in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):801-10.
1993: R K Bommakanti; Karl-Norbert Klotz; Edward A Dratz; Algirdas J Jesaitis
A carboxyl-terminal tail peptide of neutrophil chemotactic receptor disrupts its physical complex with G protein.
Journal of leukocyte biology 1993;54(6):572-7.
1993: Algirdas J Jesaitis; R W Erickson; Karl-Norbert Klotz; R K Bommakanti; Daniel W Siemsen
Functional molecular complexes of human N-formyl chemoattractant receptors and actin.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5653-65.
1993: Algirdas J Jesaitis; Karl-Norbert Klotz
Cytoskeletal regulation of chemotactic receptors: molecular complexation of N-formyl peptide receptors with G proteins and actin.
European journal of haematology 1993;51(5):288-93.
1992: G González-Calero; A Cubero; Karl-Norbert Klotz
G-protein-coupled A1 adenosine receptors in coated vesicles of mammalian brain: characterization by radioligand binding and photoaffinity labelling.
Cellular signalling 1992;4(6):737-45.
1992: D Nolte; Anna Lorenzen; H A Lehr; F J Zimmer; Karl-Norbert Klotz; K Messmer
Reduction of postischemic leukocyte-endothelium interaction by adenosine via A2 receptor.
Naunyn-Schmiedeberg's archives of pharmacology 1992;346(2):234-7.
1992: William S Spielman; Karl-Norbert Klotz; Lois J Arend; B A Olson; D G LeVier; U Schwabe
Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule.
The American journal of physiology 1992;263(2 Pt 1):C502-8.
1992: Gloria Cristalli; Anna Maria Eleuteri; Sauro Vittori; Rosaria Volpini; M J Lohse; Karl-Norbert Klotz
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Journal of medicinal chemistry 1992;35(13):2363-8.
1992: R K Bommakanti; Gary M Bokoch; J O Tolley; R E Schreiber; Daniel W Siemsen; Karl-Norbert Klotz; Algirdas J Jesaitis
Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein. Inhibition by pertussis toxin-catalyzed ADP ribosylation.
The Journal of biological chemistry 1992;267(11):7576-81.
1992: I Ott; M J Lohse; Karl-Norbert Klotz; I Vogt-Moykopf; Ulrich Schwabe
Effects of adenosine on histamine release from human lung fragments.
International archives of allergy and immunology 1992;98(1):50-6.
1991: Dietrich van Calker; R Steber; Karl-Norbert Klotz; Waldemar Greil
Carbamazepine distinguishes between adenosine receptors that mediate different second messenger responses.
European journal of pharmacology 1991;206(4):285-90.
1991: M J Lohse; Karl-Norbert Klotz; Ulrich Schwabe
Mechanism of A2 adenosine receptor activation. I. Blockade of A2 adenosine receptors by photoaffinity labeling.
Molecular pharmacology 1991;39(4):517-23.
1991: Karl-Norbert Klotz; H Vogt; H Tawfik-Schlieper
Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling.
Naunyn-Schmiedeberg's archives of pharmacology 1991;343(2):196-201.
1990: G Gimpl; R Gerstberger; U Mauss; Karl-Norbert Klotz; R E Lang
Solubilization and characterization of active neuropeptide Y receptors from rabbit kidney.
The Journal of biological chemistry 1990;265(30):18142-7.
1990: Karl-Norbert Klotz; R Keil; F J Zimmer; Ulrich Schwabe
Guanine nucleotide effects on 8-cyclopentyl-1,3-[3H]dipropylxanthine binding to membrane-bound and solubilized A1 adenosine receptors of rat brain.
Journal of neurochemistry 1990;54(6):1988-94.
1990: A Wilken; H Tawfik-Schlieper; Karl-Norbert Klotz; Ulrich Schwabe
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes.
Molecular pharmacology 1990;37(6):916-20.
1990: E Gross; Thomas Ruzicka; B von Restorff; Wilhelm Stolz; Karl-Norbert Klotz
High-affinity binding and lack of growth-promoting activity of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) in a human epidermal cell line.
The Journal of investigative dermatology 1990;94(4):446-51.
1989: H Tawfik-Schlieper; Karl-Norbert Klotz; V A Kreye; Ulrich Schwabe
Characterization of the K(+)-channel-coupled adenosine receptor in guinea pig atria.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6):684-8.
1989: Karl-Norbert Klotz; M J Lohse; Ulrich Schwabe; Gloria Cristalli; Sauro Vittori; Mario Grifantini
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6):679-83.
1989: M J Lohse; K Maurer; Karl-Norbert Klotz; U Schwabe
Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells.
British journal of pharmacology 1989;98(4):1392-8.
1989: M Reddington; Karl-Norbert Klotz; M J Lohse; B Hietel
Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide.
FEBS letters 1989;252(1-2):125-8.
1989: F Meier; E Gross; Karl-Norbert Klotz; Thomas Ruzicka
Leukotriene B4 receptors on neutrophils in patients with psoriasis and atopic eczema.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1989;2(2):61-7.
1988: M J Lohse; Karl-Norbert Klotz; M J Salzer; Ulrich Schwabe
Adenosine regulates the Ca2+ sensitivity of mast cell mediator release.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8875-9.
1988: Karl-Norbert Klotz; M J Lohse; Ulrich Schwabe
Chemical modification of A1 adenosine receptors in rat brain membranes. Evidence for histidine in different domains of the ligand binding site.
The Journal of biological chemistry 1988;263(33):17522-6.
1988: M J Lohse; Karl-Norbert Klotz; E Diekmann; K Friedrich; U Schwabe
2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.
European journal of pharmacology 1988;156(1):157-60.
1988: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sauro Vittori; Karl-Norbert Klotz; M J Lohse
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
Journal of medicinal chemistry 1988;31(6):1179-83.
1988: M J Lohse; Karl-Norbert Klotz; Ulrich Schwabe; Gloria Cristalli; Sauro Vittori; Mario Grifantini
2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(6):687-9.
1988: M J Lohse; B Elger; J Lindenborn-Fotinos; Karl-Norbert Klotz; Ulrich Schwabe
Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(1):64-8.
1987: M J Lohse; S Böser; Karl-Norbert Klotz; Ulrich Schwabe
Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects.
Naunyn-Schmiedeberg's archives of pharmacology 1987;336(2):211-7.
1987: M J Lohse; Karl-Norbert Klotz; J Lindenborn-Fotinos; M Reddington; Ulrich Schwabe; R A Olsson
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1987;336(2):204-10.
1986: Karl-Norbert Klotz; M J Lohse
The glycoprotein nature of A1 adenosine receptors.
Biochemical and biophysical research communications 1986;140(1):406-13.
1986: M J Lohse; Karl-Norbert Klotz; U Schwabe
Agonist photoaffinity labeling of A1 adenosine receptors: persistent activation reveals spare receptors.
Molecular pharmacology 1986;30(4):403-9.
1986: Karl-Norbert Klotz; M J Lohse; U Schwabe
Characterization of the solubilized A1 adenosine receptor from rat brain membranes.
Journal of neurochemistry 1986;46(5):1528-34.
1986: M J Lohse; Karl-Norbert Klotz; U Schwabe
Effects of temperature and membrane phase transitions on ligand binding to alpha 2-receptors of human platelets.
Molecular pharmacology 1986;29(3):228-34.
1986: R Koch; A Deger; Hans-Martin Jäck; Karl-Norbert Klotz; D Schenzle; H Krämer; S Kelm; G Müller; R Rapp; U Weber
Characterization of solubilized insulin receptors from rat liver microsomes. Existence of two receptor species with different binding properties.
European journal of biochemistry / FEBS 1986;154(2):281-7.
1985: M J Lohse; Karl-Norbert Klotz; K H Jakobs; U Schwabe
Barbiturates are selective antagonists at A1 adenosine receptors.
Journal of neurochemistry 1985;45(6):1761-70.
1985: Karl-Norbert Klotz; Gloria Cristalli; Mario Grifantini; Sauro Vittori; M J Lohse
Photoaffinity labeling of A1-adenosine receptors.
The Journal of biological chemistry 1985;260(27):14659-64.
1985: D Ukena; C G Schirren; Karl-Norbert Klotz; U Schwabe
Evidence for an A2 adenosine receptor in guinea pig lung.
Naunyn-Schmiedeberg's archives of pharmacology 1985;331(1):89-95.
1984: M J Lohse; Karl-Norbert Klotz; D Ukena; U Schwabe
Characterization of [3H]phenobarbital binding to rat brain membranes.
Neuroscience letters 1984;52(1-2):97-101.