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John Bushweller

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Benjamin I Leach; Charles R Schmidt; Tomasz Cierpicki; Stephanie A Johnson; Aravinda Kuntimaddi; John H Bushweller
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.
Huiling Chen; Fei Ji; Victor Olman; Charles K Mobley; Yizhou Liu; Yunpeng Zhou; John H Bushweller; James H Prestegard; Ying Xu
Optimal mutation sites for PRE data collection and membrane protein structure prediction.
Takeshi Corpora; Liya Roudaia; Zaw Min Oo; Wei Chen; Ekaterina Manuylova; Xiongwei Cai; Michael J Chen; Tomasz Cierpicki; Nancy A Speck; John H Bushweller
Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.

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All Publications

2013: Benjamin I Leach; Charles R Schmidt; Tomasz Cierpicki; Stephanie A Johnson; Aravinda Kuntimaddi; John H Bushweller
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.
Structure (London, England : 1993) 2013;21(1):176-83.
2011: Huiling Chen; Fei Ji; Victor Olman; Charles K Mobley; Yizhou Liu; Yunpeng Zhou; John H Bushweller; James H Prestegard; Ying Xu
Optimal mutation sites for PRE data collection and membrane protein structure prediction.
Structure (London, England : 1993) 2011;19(4):484-95.
2010: Takeshi Corpora; Liya Roudaia; Zaw Min Oo; Wei Chen; Ekaterina Manuylova; Xiongwei Cai; Michael J Chen; Tomasz Cierpicki; Nancy A Speck; John H Bushweller
Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.
Journal of molecular biology 2010;402(3):560-77.
2010: Virginie Früh; Yunpeng Zhou; Dan Chen; Caroline Loch; Eiso Ab; Yelena N Grinkova; Herman Verheij; Stephen G Sligar; John H Bushweller; Gregg Siegal
Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.
Chemistry & biology 2010;17(8):881-91.
2010: Sangho Park; Ute Osmers; Gayathree Raman; Rebecca H Schwantes; Manuel O Diaz; John H Bushweller
The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .
Biochemistry 2010;49(31):6576-86.
2010: Tomasz Cierpicki; Laurie E Risner; Jolanta Grembecka; Stephen M Lukasik; Relja Popovic; Monika Omonkowska; David D Shultis; Nancy J Zeleznik-Le; John H Bushweller
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
Nature structural & molecular biology 2010;17(1):62-8.
2009: Tomasz Cierpicki; Jakub Bielnicki; Meiying Zheng; Jakub Gruszczyk; Marta Kasterka; Maxim Petoukhov; Aming Zhang; Erik J Fernandez; Dmitri I Svergun; Urszula Derewenda; John H Bushweller; Zygmunt S Derewenda
The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.
Protein science : a publication of the Protein Society 2009;18(10):2067-79.
2009: Sangho Park; Nancy A Speck; John H Bushweller
The role of CBFbeta in AML1-ETO's activity.
Blood 2009;114(13):2849-50.
2009: Sangho Park; Wei Chen; Tomasz Cierpicki; Marco Tonelli; Xiongwei Cai; Nancy A Speck; John H Bushweller
Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood 2009;113(15):3558-67.
2009: Liya Roudaia; Matthew D Cheney; Ekaterina Manuylova; Wei Chen; Michelle Morrow; Sangho Park; Chung-Tsai Lee; Prabhjot Kaur; Owen Williams; John H Bushweller; Nancy A Speck
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Blood 2009;113(13):3070-9.
2009: Meiying Zheng; Tomasz Cierpicki; Ko Momotani; Mykhaylo V Artamonov; Urszula Derewenda; John H Bushweller; Avril V Somlyo; Zygmunt S Derewenda
On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.
BMC structural biology 2009;9():36.
2008: Yunpeng Zhou; Tomasz Cierpicki; Ricardo H Flores Jimenez; Stephen M Lukasik; Jeffrey F Ellena; David S Cafiso; Hiroshi Kadokura; Jonathan R. Beckwith; John H Bushweller
NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Molecular cell 2008;31(6):896-908.
2008: Frank E Erfurth; Relja Popovic; Jolanta Grembecka; Tomasz Cierpicki; Catherine Theisler; Zhen-Biao Xia; Tara Stuart; Manuel O Diaz; John H Bushweller; Nancy J Zeleznik-Le
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(21):7517-22.
2007: Michael J Gorczynski; Jolanta Grembecka; Yunpeng Zhou; Yali Kong; Liya Roudaia; Mike Douvas; Miki Newman; Izabela Bielnicka; Gwen Baber; Takeshi Corpora; Jianxia Shi; Mohini Sridharan; Ryan H Lilien; Bruce Randall Donald; Nancy A Speck; Milton L Brown; John H Bushweller
Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.
Chemistry & biology 2007;14(10):1186-97.
2007: Yizhou Liu; Wei Chen; Justin Gaudet; Matthew D Cheney; Liya Roudaia; Tomasz Cierpicki; Rachel C Klet; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer cell 2007;11(6):483-97.
2007: Christina J Matheny; Maren E Speck; Patrick R Cushing; Yunpeng Zhou; Takeshi Corpora; Michael Regan; Miki Newman; Liya Roudaia; Caroline L Speck; Ting-Lei Gu; Stephen M Griffey; John H Bushweller; Nancy A Speck
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.
The EMBO journal 2007;26(4):1163-75.
2006: Zhe Li; Stephen M Lukasik; Yizhou Liu; Jolanta Grembecka; Izabela Bielnicka; John H Bushweller; Nancy A Speck
A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.
Journal of molecular biology 2006;364(5):1073-83.
2006: Tomasz Cierpicki; Myung Hee Kim; David R Cooper; Urszula Derewenda; John H Bushweller; Zygmunt S Derewenda
The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.
Proteins 2006;64(4):874-82.
2006: Tomasz Cierpicki; Binyong Liang; Lukas K Tamm; John H Bushweller
Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.
Journal of the American Chemical Society 2006;128(21):6947-51.
2006: Binyong Liang; John H Bushweller; Lukas K Tamm
Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.
Journal of the American Chemical Society 2006;128(13):4389-97.
2006: Yizhou Liu; Matthew D Cheney; Justin Gaudet; Maksymilian Chruszcz; Stephen M Lukasik; Daisuke Sugiyama; Jeff Lary; James Cole; Zbyszek Dauter; Wladek Minor; Nancy A Speck; John H Bushweller
The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.
Cancer cell 2006;9(4):249-60.
2006: Jolanta Grembecka; Tomasz Cierpicki; Yancho Devedjiev; Urszula Derewenda; Beom Sik Kang; John H Bushweller; Zygmunt S Derewenda
The binding of the PDZ tandem of syntenin to target proteins.
Biochemistry 2006;45(11):3674-83.
2006: Stephen M Lukasik; Tomasz Cierpicki; Matthew Borloz; Jolanta Grembecka; Allen Everett; John H Bushweller
High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.
Protein science : a publication of the Protein Society 2006;15(2):314-23.
2005: Yinling Li; Xing Han; Alex L Lai; John H Bushweller; David S Cafiso; Lukas K Tamm
Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion.
Journal of virology 2005;79(18):12065-76.
2005: David L Brautigan; M Brown; S Grindrod; G Chinigo; Allison Kruszewski; Stephen M Lukasik; John H Bushweller; M Horal; S Keller; S Tamura; Douglas B Heimark; J Price; A N Larner; James M Larner
Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.
Biochemistry 2005;44(33):11067-73.
2005: Tomasz Cierpicki; John H Bushweller; Zygmunt S Derewenda
Probing the supramodular architecture of a multidomain protein: the structure of syntenin in solution.
Structure (London, England : 1993) 2005;13(2):319-27.
2004: Tomasz Cierpicki; John H Bushweller
Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.
Journal of the American Chemical Society 2004;126(49):16259-66.
2004: Jiangli Yan; Yizhou Liu; Stephen M Lukasik; Nancy A Speck; John H Bushweller
CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.
Nature structural & molecular biology 2004;11(9):901-6.
2004: Michael J Gorczynski; Rachel M Leal; Susan Mooberry; John H Bushweller; Milton L Brown
Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.
Bioorganic & medicinal chemistry 2004;12(5):1029-36.
2003: Lukas K Tamm; Frits Abildgaard; Ashish Arora; Heike Blad; John H Bushweller
Structure, dynamics and function of the outer membrane protein A (OmpA) and influenza hemagglutinin fusion domain in detergent micelles by solution NMR.
FEBS letters 2003;555(1):139-43.
2003: Lina Zhang; Zhe Li; Jiangli Yan; Padmanava Pradhan; Takeshi Corpora; Matthew D Cheney; Jerónimo Bravo; Amy J Warren; John H Bushweller; Nancy A Speck
Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit.
The Journal of biological chemistry 2003;278(35):33097-104.
2003: Zhe Li; Jiangli Yan; Christina J Matheny; Takeshi Corpora; Jerónimo Bravo; Amy J Warren; John H Bushweller; Nancy A Speck
Energetic contribution of residues in the Runx1 Runt domain to DNA binding.
The Journal of biological chemistry 2003;278(35):33088-96.
2003: Myung Hee Kim; Tomasz Cierpicki; Urszula Derewenda; Daniel Krowarsch; Yuanyi Feng; Yancho Devedjiev; Zbigniew Dauter; Christopher Walsh; Jacek Otlewski; John H Bushweller; Zygmunt S Derewenda
The DCX-domain tandems of doublecortin and doublecortin-like kinase.
Nature structural biology 2003;10(5):324-33.
2003: Lina Zhang; Stephen M Lukasik; Nancy A Speck; John H Bushweller
Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.
Blood cells, molecules & diseases 2003;30(2):147-56.
2003: Tomasz Cierpicki; Myung Hee Kim; Jacek Otlewski; Zygmunt S Derewenda; John H Bushweller
Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin.
Journal of biomolecular NMR 2003;25(1):81-2.
2002: Stephen M Lukasik; Lina Zhang; Takeshi Corpora; Sarah Tomanicek; Yuanhong Li; Mondira Kundu; Kari Hartman; P Paul Liu; Thomas M Laue; Rodney L Biltonen; Nancy A Speck; John H Bushweller
Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.
Nature structural biology 2002;9(9):674-9.
2002: Jiangli Yan; Takeshi Corpora; Padmanava Pradhan; John H Bushweller
MQ-hCN-based pulse sequences for the measurement of 13C1'-1H1', 13C1'-15N, 1H1'-15N, 13C1'-13C2', 1H1'-13C2',13C6/8-1H6/8, 13C6/8-15N, 1H6/8-15N, 13C6-13C5, 1H6-13C5 dipolar couplings in 13C, 15N-labeled DNA (and RNA).
Journal of biomolecular NMR 2002;22(1):9-20.
2001: Xing Han; John H Bushweller; David S Cafiso; Lukas K Tamm
Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin.
Nature structural biology 2001;8(8):715-20.
2001: Jiangli Yan; John H Bushweller
An optimized PCR-based procedure for production of 13C/15N-labeled DNA.
Biochemical and biophysical research communications 2001;284(2):295-300.
2001: A Arora; Frits Abildgaard; John H Bushweller; Lukas K Tamm
Structure of outer membrane protein A transmembrane domain by NMR spectroscopy.
Nature structural biology 2001;8(4):334-8.
2000: YY Tang; J Shi; Lina Zhang; A Davis; Jerónimo Bravo; Amy J Warren; Nancy A Speck; John H Bushweller
Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.
The Journal of biological chemistry 2000;275(50):39579-88.
2000: John H Bushweller
CBF--a biophysical perspective.
Seminars in cell & developmental biology 2000;11(5):377-82.
2000: YY Tang; BE Crute; JJ Kelley; X Huang; Jiangli Yan; J Shi; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.
FEBS letters 2000;470(2):167-72.
2000: Chris Bailey-Kellogg; A Widge; JJ Kelley; MJ Berardi; John H Bushweller; Bruce Randall Donald
The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data.
Journal of computational biology : a journal of computational molecular cell biology 2000;7(3-4):537-58.
1999: MJ Berardi; C Sun; M Zehr; Frits Abildgaard; J Peng; Nancy A Speck; John H Bushweller
The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.
Structure (London, England : 1993) 1999;7(10):1247-56.
1999: W J Song; M G Sullivan; Robert D Legare; S Hutchings; X Tan; Dubravka Kufrin; J Ratajczak; I C Resende; C Haworth; R Hock; Mignon L Loh; C Felix; Denis-Claude Roy; Lambert Busque; David M Kurnit; C Willman; A M Gewirtz; Nancy A Speck; John H Bushweller; Frederick P Li; K Gardiner; Mortimer Poncz; John M Maris; D Gary Gilliland
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
Nature genetics 1999;23(2):166-75.
1999: MJ Berardi; John H Bushweller
Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction.
Journal of molecular biology 1999;292(1):151-61.
1999: X Huang; J W Peng; Nancy A Speck; John H Bushweller
Solution structure of core binding factor beta and map of the CBF alpha binding site.
Nature structural biology 1999;6(7):624-7.
1998: Xian Chen; S V Santhana Mariappan; JJ Kelley; John H Bushweller; E Morton Bradbury; Goutam Gupta
A PCR-based method for uniform 13C/15N labeling of long DNA oligomers.
FEBS letters 1998;436(3):372-6.
1998: X Huang; Nancy A Speck; John H Bushweller
Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).
Journal of biomolecular NMR 1998;12(3):459-60.
1998: JJ Kelley; John H Bushweller
1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form.
Journal of biomolecular NMR 1998;12(2):353-5.
1998: C Sun; MJ Berardi; John H Bushweller
The NMR solution structure of human glutaredoxin in the fully reduced form.
Journal of molecular biology 1998;280(4):687-701.
1998: MJ Berardi; C L Pendred; John H Bushweller
Preparation, characterization, and complete heteronuclear NMR resonance assignments of the glutaredoxin (C14S)-ribonucleotide reductase B1 737-761 (C754S) mixed disulfide.
Biochemistry 1998;37(17):5849-57.
1998: X Huang; BE Crute; C Sun; YY Tang; JJ Kelley; A F Lewis; Kari Hartman; Thomas M Laue; Nancy A Speck; John H Bushweller
Overexpression, purification, and biophysical characterization of the heterodimerization domain of the core-binding factor beta subunit.
The Journal of biological chemistry 1998;273(4):2480-7.
1997: JJ Kelley; T M Caputo; S F Eaton; Thomas M Laue; John H Bushweller
Comparison of backbone dynamics of reduced and oxidized Escherichia coli glutaredoxin-1 using 15N NMR relaxation measurements.
Biochemistry 1997;36(16):5029-44.
1997: C Sun; A Holmgren; John H Bushweller
Complete 1H, 13C, and 15N NMR resonance assignments and secondary structure of human glutaredoxin in the fully reduced form.
Protein science : a publication of the Protein Society 1997;6(2):383-90.
1996: Qingru Wang; Terryl Stacy; J D Miller; A F Lewis; Ting-Lei Gu; X Huang; John H Bushweller; J C Bories; F W Alt; G Ryan; P Paul Liu; Anthony Wynshaw-Boris; Michael Binder; M Marín-Padilla; A H Sharpe; Nancy A Speck
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
Cell 1996;87(4):697-708.
1996: BE Crute; A F Lewis; Z Wu; John H Bushweller; Nancy A Speck
Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain.
The Journal of biological chemistry 1996;271(42):26251-60.