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Eric Lai

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TOP 3
Qi Dai; Ryan Insolera; Song-Hai Shi; Li Chin Wong; Celia Andreu-Agullo; Eric C Lai
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
Pedro Miura; Sol Shenker; Jakub O Westholm; Celia Andreu-Agullo; Eric C Lai
Widespread and extensive lengthening of 3' UTRs in the mammalian brain.
Katsutomo Okamura; Li Zhou; Erik Ladewig; Eric C Lai
Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals.

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All Publications

2013: Qi Dai; Ryan Insolera; Song-Hai Shi; Li Chin Wong; Celia Andreu-Agullo; Eric C Lai
BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
Development (Cambridge, England) 2013;140(9):1892-902.
2013: Pedro Miura; Sol Shenker; Jakub O Westholm; Celia Andreu-Agullo; Eric C Lai
Widespread and extensive lengthening of 3' UTRs in the mammalian brain.
Genome research 2013;23(5):812-25.
2013: Katsutomo Okamura; Li Zhou; Erik Ladewig; Eric C Lai
Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals.
Genes & development 2013;27(7):778-92.
2012: Erik Ladewig; Katsutomo Okamura; Jakub O Westholm; Alex S Flynt; Eric C Lai
Discovery of hundreds of mirtrons in mouse and human small RNA data.
Genome research 2012;22(9):1634-45.
2012: Fernando Bejarano; Diane Bortolamiol-Becet; Yu-Ting Chou; Qi Dai; Hong Duan; Tudor A Fulga; Kevin Kim; Jian-Quan Ni; Norbert Perrimon; David R Raleigh; Abil Saj; Kailiang Sun; David Van Vactor; Jr-Shiuan Yang; Eric C Lai
A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.
Development (Cambridge, England) 2012;139(15):2821-31.
2012: Peter Smibert; Jakub O Westholm; Dayu Zhang; Gemma May; Pedro Miura; Sol Shenker; Justen Andrews; James B Brown; Joe Carlson; Susan E Celniker; Peter Cherbas; Michael O Duff; Brian D Eads; Robert C Eisman; Brenton R Graveley; Thomas Kaufman; Eric C Lai
Global patterns of tissue-specific alternative polyadenylation in Drosophila.
Cell reports 2012;1(3):277-89.
2012: Kailiang Sun; Kazuya Tsurudome; Jakub Orzechowski Westholm; Yubing Lu; Doron Betel; Chris Q Doe; Fen-Biao Gao; Joshua W Hagen; A Pejmun Haghighi; Minoree Kohwi; Eric C Lai
Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants.
PLoS genetics 2012;8(2):e1002515.
2011: Jakub O Westholm; Eric C Lai
Mirtrons: microRNA biogenesis via splicing.
Biochimie 2011;93(11):1897-904.
2011: Jr-Shiuan Yang; Eric C Lai
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants.
Molecular cell 2011;43(6):892-903.
2011: Hong Duan; Joshua Kavaler; Fernando Bejarano; Qi Dai; Giorgio Medranda; Nicolas Nègre; Eric C Lai
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.
The EMBO journal 2011;30(15):3120-33.
2011: Alex S Flynt; Eric C Lai
RNAi in Xenopus: look before you leap.
Genes & development 2011;25(11):1105-8.
2011: Wei-Jen Chung; Phaedra Agius; Jakub O Westholm; Michael Chen; Katsutomo Okamura; Nicolas Robine; Christina S Leslie; Eric C Lai
Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans.
Genome research 2011;21(2):286-300.
2011: Jr-Shiuan Yang; Michael D Phillips; Doron Betel; Ping Mu; Andrea Ventura; Adam C Siepel; Kevin C Chen; Eric C Lai
Widespread regulatory activity of vertebrate microRNA* species.
RNA (New York, N.Y.) 2011;17(2):312-26.
2011: Katsutomo Okamura; Nicolas Robine; Ying Liu; Qinghua Liu; Eric C Lai
R2D2 organizes small regulatory RNA pathways in Drosophila.
Molecular and cellular biology 2011;31(4):884-96.
2010: Jr-Shiuan Yang; Eric C Lai
Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates.
Cell cycle (Georgetown, Tex.) 2010;9(22):4455-60.
2010: Peter Smibert; Eric C Lai
A view from Drosophila: multiple biological functions for individual microRNAs.
Seminars in cell & developmental biology 2010;21(7):745-53.
2010: Jr-Shiuan Yang; Thomas Maurin; Nicolas Robine; Kasper D Rasmussen; Kate L Jeffrey; Rohit Chandwani; Eirini P Papapetrou; Michel Sadelain; Dónal O'Carroll; Eric C Lai
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15163-8.
2010: Alex S Flynt; Jaclyn C Greimann; Wei-Jen Chung; Christopher D Lima; Eric C Lai
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila.
Molecular cell 2010;38(6):900-7.
2010: Ingo Büssing; Jr-Shiuan Yang; Eric C Lai; Helge Grosshans
The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila.
The EMBO journal 2010;29(11):1830-9.
2010: Katsutomo Okamura; Eric C Lai
A deathly DNase activity for dicer.
Developmental cell 2010;18(5):692-4.
2010: Fernando Bejarano; Peter Smibert; Eric C Lai
miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only.
Developmental biology 2010;338(1):63-73.
2010: Qingfa Wu; Yingjun Luo; Rui Lu; Nelson Lau; Eric C Lai; Wan-Xiang Li; Shou-Wei Ding
Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1606-11.
2010: Eugene Berezikov; Na Liu; Alex S Flynt; Emily Hodges; Michelle Rooks; Gregory J Hannon; Eric C Lai
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.
Nature genetics 2010;42(1):6-9; author reply 9-10.
2009: Nicolas Robine; Nelson C Lau; Sudha Balla; Zhigang Jin; Katsutomo Okamura; Satomi Kuramochi-Miyagawa; Michael D Blower; Eric C Lai
A broadly conserved pathway generates 3'UTR-directed primary piRNAs.
Current biology : CB 2009;19(24):2066-76.
2009: Katsutomo Okamura; Na Liu; Eric C Lai
Distinct mechanisms for microRNA strand selection by Drosophila Argonautes.
Molecular cell 2009;36(3):431-44.
2009: Katsutomo Okamura; Eric C Lai
[Diversity and complexity of dicer dependent small RNA networks in animals].
Seikagaku. The Journal of Japanese Biochemical Society 2009;81(10):904-9.
2009: Nelson C Lau; Nicolas Robine; Raquel Martin; Wei-Jen Chung; Yuzo Niki; Eugene Berezikov; Eric C Lai
Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line.
Genome research 2009;19(10):1776-85.
2009: Susan E Celniker; Laura A L Dillon; Mark B Gerstein; Kristin C Gunsalus; Steven Henikoff; Gary Karpen; Manolis Kellis; Eric C Lai; Jason Dillon Lieb; David M MacAlpine; Gos Micklem; Fabio Piano; Michael Snyder; Lincoln Stein; Kevin P White; Robert H Waterston
Unlocking the secrets of the genome.
Nature 2009;459(7249):927-30.
2009: Fabrice Roegiers; Joshua Kavaler; Nicholas Tolwinski; Yu-Ting Chou; Hong Duan; Fernando Bejarano; Diana Zitserman; Eric C Lai
Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks.
Genetics 2009;182(1):407-10.
2009: Alex Flynt; Na Liu; Raquel Martin; Eric C Lai
Dicing of viral replication intermediates during silencing of latent Drosophila viruses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5270-5.
2009: Raquel Martin; Peter Smibert; Abdullah Yalcin; David M Tyler; Ulrich Schäfer; Thomas Tuschl; Eric C Lai
A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.
Molecular and cellular biology 2009;29(3):861-70.
2008: Alex S Flynt; Eric C Lai
Biological principles of microRNA-mediated regulation: shared themes amid diversity.
Nature reviews. Genetics 2008;9(11):831-42.
2008: Na Liu; Katsutomo Okamura; David M Tyler; Michael D Phillips; Wei-Jen Chung; Eric C Lai
The evolution and functional diversification of animal microRNA genes.
Cell research 2008;18(10):985-96.
2008: Katsutomo Okamura; Wei-Jen Chung; Eric C Lai
The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs.
Cell cycle (Georgetown, Tex.) 2008;7(18):2840-5.
2008: Katsutomo Okamura; Eric C Lai
Endogenous small interfering RNAs in animals.
Nature reviews. Molecular cell biology 2008;9(9):673-8.
2008: Peter Smibert; Eric C Lai
Lessons from microRNA mutants in worms, flies and mice.
Cell cycle (Georgetown, Tex.) 2008;7(16):2500-8.
2008: Joshua W Hagen; Eric C Lai
microRNA control of cell-cell signaling during development and disease.
Cell cycle (Georgetown, Tex.) 2008;7(15):2327-32.
2008: Katsutomo Okamura; Wei-Jen Chung; J Graham Ruby; Huili Guo; David P Bartel; Eric C Lai
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs.
Nature 2008;453(7196):803-6.
2008: Wei-Jen Chung; Katsutomo Okamura; Raquel Martin; Eric C Lai
Endogenous RNA interference provides a somatic defense against Drosophila transposons.
Current biology : CB 2008;18(11):795-802.
2008: Katsutomo Okamura; Sudha Balla; Raquel Martin; Na Liu; Eric C Lai
Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster.
Nature structural & molecular biology 2008;15(6):581-90.
2008: Katsutomo Okamura; Michael D Phillips; David M Tyler; Hong Duan; Yu-ting Chou; Eric C Lai
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution.
Nature structural & molecular biology 2008;15(4):354-63.
2008: Pelin Cayirlioglu; Ilona Grunwald Kadow; Xiaoli Zhan; Katsutomo Okamura; Greg S B Suh; Dorian Gunning; Eric C Lai; S Lawrence Zipursky
Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems.
Science (New York, N.Y.) 2008;319(5867):1256-60.
2008: David M Tyler; Katsutomo Okamura; Wei-Jen Chung; Joshua W Hagen; Eugene Berezikov; Gregory J Hannon; Eric C Lai
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.
Genes & development 2008;22(1):26-36.
2007: J Graham Ruby; Alexander Stark; Wendy K Johnston; Manolis Kellis; David P Bartel; Eric C Lai
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs.
Genome research 2007;17(12):1850-64.
2007: Serena J Silver; Joshua W Hagen; Katsutomo Okamura; Norbert Perrimon; Eric C Lai
Functional screening identifies miR-315 as a potent activator of Wingless signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18151-6.
2007: Alexander Stark; Michael F Lin; Pouya Kheradpour; Jakob S Pedersen; Leopold Parts; Joseph W Carlson; Madeline A Crosby; Matthew D Rasmussen; Sushmita Roy; Ameya N Deoras; J Graham Ruby; Julius Brennecke; Emily Hodges; Angie S Hinrichs; Anat Caspi; Benedict Paten; Seung-Won Park; Mira V Han; Morgan L Maeder; Benjamin J Polansky; Bryanne E Robson; Stein Aerts; Jacques van Helden; Bassem Hassan; Donald G Gilbert; Deborah A Eastman; Michael Rice; Michael Weir; Matthew W Hahn; Yongkyu Park; Colin N Dewey; Lior Pachter; W James Kent; David Haussler; Eric C Lai; David P Bartel; Gregory J Hannon; Thomas C Kaufman; Michael B Eisen; andrew clark; Douglas Smith; Susan E Celniker; William M Gelbart; Manolis Kellis
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.
Nature 2007;450(7167):219-32.
2007: Yu-ting Chou; Bergin Tam; Fabien Linay; Eric C Lai
Transgenic inhibitors of RNA interference in Drosophila.
Fly 2007;1(6):311-6.
2007: Eugene Berezikov; Wei-Jen Chung; Jason Willis; Edwin Cuppen; Eric C Lai
Mammalian mirtron genes.
Molecular cell 2007;28(2):328-36.
2007: Katsutomo Okamura; Joshua W Hagen; Hong Duan; David M Tyler; Eric C Lai
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila.
Cell 2007;130(1):89-100.
2005: Matthew Ronshaugen; Frédéric Biemar; Jessica Piel; Mike Levine; Eric C Lai
The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings.
Genes & development 2005;19(24):2947-52.
2005: A Aziz Aboobaker; Pavel Tomancak; Nipam Patel; Gerald M Rubin; Eric C Lai
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18017-22.
2005: Eric C Lai
miRNAs: whys and wherefores of miRNA-mediated regulation.
Current biology : CB 2005;15(12):R458-60.
2005: Eric C Lai; Bergin Tam; Gerald M Rubin
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs.
Genes & development 2005;19(9):1067-80.
2005: Eric C Lai; Fabrice Roegiers; Xiaoli Qin; Yuh Nung Jan; Gerald M Rubin
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.
Development (Cambridge, England) 2005;132(10):2319-32.
2005: Hailan Hu; Ming Li; Juan Pablo Labrador; Jason McEwen; Eric C Lai; Corey S Goodman; Greg J Bashaw
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4613-8.
2005: Nelson C Lau; Eric C Lai
Diverse roles for RNA in gene regulation.
Genome biology 2005;6(4):315.
2004: Eric C Lai; Virginie Orgogozo
A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity.
Developmental biology 2004;269(1):1-17.
2004: Eric C Lai
Notch signaling: control of cell communication and cell fate.
Development (Cambridge, England) 2004;131(5):965-73.
2004: Eric C Lai; Colin Wiel; Gerald M Rubin
Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes.
RNA (New York, N.Y.) 2004;10(2):171-5.
2004: Eric C Lai
Predicting and validating microRNA targets.
Genome biology 2004;5(9):115.
2003: Eric C Lai
microRNAs: runts of the genome assert themselves.
Current biology : CB 2003;13(23):R925-36.
2003: Eric C Lai
Lipid rafts make for slippery platforms.
The Journal of cell biology 2003;162(3):365-70.
2003: Eric C Lai
Drosophila tufted is a gain-of-function allele of the proneural gene amos.
Genetics 2003;163(4):1413-25.
2003: Eric C Lai
RNA sensors and riboswitches: self-regulating messages.
Current biology : CB 2003;13(7):R285-91.
2003: Eric C Lai; Pavel Tomancak; Robert W Williams; Gerald M Rubin
Computational identification of Drosophila microRNA genes.
Genome biology 2003;4(7):R42.
2002: Eric C Lai
Developmental signaling: shrimp and strawberries help flies make cones.
Current biology : CB 2002;12(21):R722-4.
2002: Eric C Lai
Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins.
EMBO reports 2002;3(9):840-5.
2002: Eric C Lai
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.
Nature genetics 2002;30(4):363-4.
2002: Eric C Lai
Notch cleavage: Nicastrin helps Presenilin make the final cut.
Current biology : CB 2002;12(6):R200-2.
2002: Eric C Lai
Protein degradation: four E3s for the notch pathway.
Current biology : CB 2002;12(2):R74-8.
2001: GA Deblandre; Eric C Lai; Chris Kintner
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.
Developmental cell 2001;1(6):795-806.
2001: Eric C Lai; GA Deblandre; Chris Kintner; Gerald M Rubin
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.
Developmental cell 2001;1(6):783-94.
2001: Eric C Lai; Gerald M Rubin
Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5637-42.
2001: Eric C Lai; Gerald M Rubin
neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development.
Developmental biology 2001;231(1):217-33.
2000: Eric C Lai; R Bodner; James W Posakony
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family.
Development (Cambridge, England) 2000;127(16):3441-55.
2000: Eric C Lai
Bristling all over.
Current biology : CB 2000;10(12):R431.
2000: Eric C Lai; R Bodner; J Kavaler; G Freschi; James W Posakony
Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.
Development (Cambridge, England) 2000;127(2):291-306.
1999: D T Nellesen; Eric C Lai; James W Posakony
Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.
Developmental biology 1999;213(1):33-53.
1999: Milton H Saier; B H Eng; S Fard; J Garg; D A Haggerty; W J Hutchinson; Donald Lee Jack; Eric C Lai; H J Liu; D P Nusinew; A M Omar; SS Pao; Ian Paulsen; J A Quan; M Sliwinski; TT Tseng; S Wachi; G B Young
Phylogenetic characterization of novel transport protein families revealed by genome analyses.
Biochimica et biophysica acta 1999;1422(1):1-56.
1998: Eric C Lai; C Burks; James W Posakony
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.
Development (Cambridge, England) 1998;125(20):4077-88.
1998: Eric C Lai; J W Posakony
Regulation of Drosophila neurogenesis by RNA:RNA duplexes?
Cell 1998;93(7):1103-4.
1997: Eric C Lai; James W Posakony
The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression.
Development (Cambridge, England) 1997;124(23):4847-56.
1997: M W Leviten; Eric C Lai; James W Posakony
The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes.
Development (Cambridge, England) 1997;124(20):4039-51.